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Kellee Siegfried PhD

TitleAdjunct Associate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Boston
100 William T Morrissey Blvd
Boston MA 02125-3300
Phone617-287-6671
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine


    Collapse Biography 
    Collapse education and training
    University of California, Davis, Davis, CA, United StatesBSGenetics
    University of Wisconsin, Madison, Madison, WI, United StatesPHDGenetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kawasaki T, Nishimura T, Tani N, Ramos C, Karaulanov E, Shinya M, Saito K, Taylor E, Ketting RF, Ishiguro KI, Tanaka M, Siegfried KR, Sakai N. Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells. Elife. 2025 Jul 24; 14. PMID: 40705004.
      Citations:    
    2. Kawasaki T, Nishimura T, Tani N, Ramos C, Karaulanov E, Shinya M, Saito K, Taylor E, Ketting RF, Ishiguro KI, Tanaka M, Siegfried KR, Sakai N. Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells. bioRxiv. 2025 Feb 05. PMID: 39605693.
      Citations:    
    3. Wang Z, Townley SL, Zhang S, Liu M, Li M, Labaf M, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Risbridger GP, Taylor RA, Lawrence MG, He HH, Selth LA, Cai C. FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer. Nat Commun. 2024 Jun 08; 15(1):4914. PMID: 38851846.
      Citations:    
    4. Han D, Labaf M, Zhao Y, Owiredu J, Zhang S, Patel K, Venkataramani K, Steinfeld JS, Han W, Li M, Liu M, Wang Z, Besschetnova A, Patalano S, Mulhearn MJ, Macoska JA, Yuan X, Balk SP, Nelson PS, Plymate SR, Gao S, Siegfried KR, Liu R, Stangis MM, Foxa G, Czernik PJ, Williams BO, Zarringhalam K, Li X, Cai C. Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs. J Clin Invest. 2024 Apr 30; 134(11). PMID: 38687617.
      Citations:    
    5. Besschetnova A, Han W, Liu M, Gao Y, Li M, Wang Z, Labaf M, Patalano S, Venkataramani K, Muriph RE, Macoska JA, Siegfried KR, Evans J, Balk SP, Gao S, Han D, Cai C. Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression. Cancer Res Commun. 2023 08; 3(8):1716-1730. PMID: 37663929.
      Citations:    
    6. Li CY, Boldt H, Parent E, Ficklin J, James A, Anlage TJ, Boyer LM, Pierce BR, Siegfried KR, Harris MP, Haag ES. Genetic tools for the study of the mangrove killifish, Kryptolebias marmoratus, an emerging vertebrate model for phenotypic plasticity. J Exp Zool B Mol Dev Evol. 2024 May; 342(3):164-177. PMID: 37553824.
      Citations:    
    7. Islam KN, Ajao A, Venkataramani K, Rivera J, Pathania S, Henke K, Siegfried KR. The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish. PLoS Genet. 2023 08; 19(8):e1010589. PMID: 37552671.
      Citations:    
    8. Wang Z, Petricca J, Liu M, Zhang S, Chen S, Li M, Besschetnova A, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Vedadi M, Arrowsmith CH, He HH, Cai C. SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2220472120. PMID: 37549269.
      Citations:    
    9. Islam KN, Modi MM, Siegfried KR. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Front Cell Dev Biol. 2021; 9:714245. PMID: 34434933.
      Citations:    
    10. Han D, Owiredu JN, Healy BM, Li M, Labaf M, Steinfeld JS, Patalano S, Gao S, Liu M, Macoska JA, Zarringhalam K, Siegfried KR, Yuan X, Rebbeck TR, Cai C. Susceptibility-Associated Genetic Variation in NEDD9 Contributes to Prostate Cancer Initiation and Progression. Cancer Res. 2021 07 15; 81(14):3766-3776. PMID: 33632899.
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    11. Siegfried KR, Steinfeld JS. Histological Analysis of Gonads in Zebrafish. Methods Mol Biol. 2021; 2218:253-263. PMID: 33606237.
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    12. Siegfried KR. It starts at the ends: The zebrafish meiotic bouquet is where it all begins. PLoS Genet. 2019 01; 15(1):e1007854. PMID: 30653505.
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    13. Webster KA, Henke K, Ingalls DM, Nahrin A, Harris MP, Siegfried KR. Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germline of zebrafish. Reproduction. 2018 04 01; 157(4):383-398. PMID: 30763280.
      Citations:    
    14. Nishimura T, Yamada K, Fujimori C, Kikuchi M, Kawasaki T, Siegfried KR, Sakai N, Tanaka M. Germ cells in the teleost fish medaka have an inherent feminizing effect. PLoS Genet. 2018 03; 14(3):e1007259. PMID: 29596424.
      Citations:    
    15. Sosnik J, Vieira WA, Webster KA, Siegfried KR, McCusker CD. A new and improved algorithm for the quantification of chromatin condensation from microscopic data shows decreased chromatin condensation in regenerating axolotl limb cells. PLoS One. 2017; 12(10):e0185292. PMID: 29023511.
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    16. Webster KA, Schach U, Ordaz A, Steinfeld JS, Draper BW, Siegfried KR. Dmrt1 is necessary for male sexual development in zebrafish. Dev Biol. 2017 02 01; 422(1):33-46. PMID: 27940159.
      Citations:    
    17. Yang L, Paul S, Trieu KG, Dent LG, Froldi F, For?s M, Webster K, Siegfried KR, Kondo S, Harvey K, Cheng L, Jim?nez G, Shvartsman SY, Veraksa A. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10583-8. PMID: 27601662.
      Citations:    
    18. Kawasaki T, Siegfried KR, Sakai N. Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture. Development. 2016 Feb 15; 143(4):566-74. PMID: 26718005.
      Citations:    
    19. Fechner S, Alvarez L, B?nigk W, M?ller A, Berger TK, Pascal R, Tr?tschel C, Poetsch A, St?lting G, Siegfried KR, Kremmer E, Seifert R, Kaupp UB. A K(+)-selective CNG channel orchestrates Ca(2+) signalling in zebrafish sperm. Elife. 2015 Dec 09; 4. PMID: 26650356.
      Citations:    
    20. Liew WC, Bartfai R, Lim Z, Sreenivasan R, Siegfried KR, Orban L. Polygenic sex determination system in zebrafish. PLoS One. 2012; 7(4):e34397. PMID: 22506019.
      Citations:    
    21. Bowen ME, Henke K, Siegfried KR, Warman ML, Harris MP. Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics. 2012 Mar; 190(3):1017-24. PMID: 22174069.
      Citations:    
    22. Saito K, Siegfried KR, N?sslein-Volhard C, Sakai N. Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants. Dev Dyn. 2011 Jul; 240(7):1779-92. PMID: 21594953.
      Citations:    
    23. Siegfried KR, N?sslein-Volhard C. Germ line control of female sex determination in zebrafish. Dev Biol. 2008 Dec 15; 324(2):277-87. PMID: 18930041.
      Citations:    
    24. Kidd AR, Miskowski JA, Siegfried KR, Sawa H, Kimble J. A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. Cell. 2005 Jun 03; 121(5):761-72. PMID: 15935762.
      Citations:    
    25. Siegfried KR, Kidd AR, Chesney MA, Kimble J. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics. 2004 Jan; 166(1):171-86. PMID: 15020416.
      Citations:    
    26. Siegfried KR, Kimble J. POP-1 controls axis formation during early gonadogenesis in C. elegans. Development. 2002 Jan; 129(2):443-53. PMID: 11807036.
      Citations:    
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