Macromolecular Substances
"Macromolecular Substances" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
| Descriptor ID |
D046911
|
| MeSH Number(s) |
D05
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Macromolecular Substances".
Below are MeSH descriptors whose meaning is more specific than "Macromolecular Substances".
This graph shows the total number of publications written about "Macromolecular Substances" by people in this website by year, and whether "Macromolecular Substances" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 2 | 2 |
| 1994 | 0 | 5 | 5 |
| 1995 | 0 | 7 | 7 |
| 1996 | 0 | 5 | 5 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 13 | 13 |
| 2003 | 0 | 12 | 12 |
| 2004 | 1 | 13 | 14 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 5 | 5 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 6 | 6 |
| 2010 | 1 | 2 | 3 |
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 2 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 5 | 6 |
| 2021 | 1 | 2 | 3 |
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Below are the most recent publications written about "Macromolecular Substances" by people in Profiles.
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Lucas BA, Himes BA, Xue L, Grant T, Mahamid J, Grigorieff N. Locating macromolecular assemblies in cells by 2D template matching with cisTEM. Elife. 2021 06 11; 10.
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Berman HM, Gierasch LM. How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1. J Biol Chem. 2021 Jan-Jun; 296:100608.
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Hwang S, Cavaliere P, Li R, Zhu LJ, Dephoure N, Torres EM. Consequences of aneuploidy in human fibroblasts with trisomy 21. Proc Natl Acad Sci U S A. 2021 02 09; 118(6).
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Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D. Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy. 2019 08; 203:170-180.
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Kaltashov IA. Mass spectrometry-based methods to study macromolecular higher order structure and interactions. Methods. 2018 07 15; 144:1-2.
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Lanier LA, Bermudez H. Living Supramolecular Polymerization of DNA. Macromol Rapid Commun. 2018 Sep; 39(17):e1800342.
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Sharma VK, Osborn MF, Hassler MR, Echeverria D, Ly S, Ulashchik EA, Martynenko-Makaev YV, Shmanai VV, Zatsepin TS, Khvorova A, Watts JK. Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo. Bioconjug Chem. 2018 07 18; 29(7):2478-2488.
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Scaletti F, Hardie J, Lee YW, Luther DC, Ray M, Rotello VM. Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies. Chem Soc Rev. 2018 May 21; 47(10):3421-3432.
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Gao J, Zhao B, Wang M, Serrano MAC, Zhuang J, Ray M, Rotello VM, Vachet RW, Thayumanavan S. Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface. J Am Chem Soc. 2018 02 21; 140(7):2421-2425.
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Wingfield JL, Mengoni I, Bomberger H, Jiang YY, Walsh JD, Brown JM, Picariello T, Cochran DA, Zhu B, Pan J, Eggenschwiler J, Gaertig J, Witman GB, Kner P, Lechtreck K. IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium. Elife. 2017 05 31; 6.