Wiskott-Aldrich Syndrome

"Wiskott-Aldrich Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.

Descriptor ID	D014923
MeSH Number(s)	C15.378.100.100.970 C15.378.463.960 C15.378.553.546.605.900 C16.320.099.970 C16.320.322.937 C20.673.627.900
Concept/Terms	Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Syndrome, Wiskott-Aldrich Wiskott Aldrich Syndrome Wiskott Syndrome Imd2 Immunodeficiency 2 Aldrich Syndrome Syndrome, Aldrich Eczema-Thrombocytopenia-Immunodeficiency Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Eczema-Thrombocytopenia-Immunodeficiency Syndromes Syndrome, Eczema-Thrombocytopenia-Immunodeficiency Syndromes, Eczema-Thrombocytopenia-Immunodeficiency

Below are MeSH descriptors whose meaning is more general than "Wiskott-Aldrich Syndrome".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Blood Coagulation Disorders [C15.378.100]
Blood Coagulation Disorders, Inherited [C15.378.100.100]
Wiskott-Aldrich Syndrome [C15.378.100.100.970]
Hemorrhagic Disorders [C15.378.463]
Wiskott-Aldrich Syndrome [C15.378.463.960]
Leukocyte Disorders [C15.378.553]
Leukopenia [C15.378.553.546]
Lymphopenia [C15.378.553.546.605]
Wiskott-Aldrich Syndrome [C15.378.553.546.605.900]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Blood Coagulation Disorders, Inherited [C16.320.099]
Wiskott-Aldrich Syndrome [C16.320.099.970]
Genetic Diseases, X-Linked [C16.320.322]
Wiskott-Aldrich Syndrome [C16.320.322.937]
Immune System Diseases [C20]
Immunologic Deficiency Syndromes [C20.673]
Lymphopenia [C20.673.627]
Wiskott-Aldrich Syndrome [C20.673.627.900]

Below are MeSH descriptors whose meaning is related to "Wiskott-Aldrich Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Wiskott-Aldrich Syndrome".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Wiskott-Aldrich Syndrome" by people in this website by year, and whether "Wiskott-Aldrich Syndrome" was a major or minor topic of these publications.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 1997 and 2008 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Total
1997	1	1
2008	1	1
2015	1	1

Below are the most recent publications written about "Wiskott-Aldrich Syndrome" by people in Profiles.

Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. Allergy. 2017 Dec; 72(12):1916-1924.

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Gerrits AJ, Leven EA, Frelinger AL, Brigstocke SL, Berny-Lang MA, Mitchell WB, Revel-Vilk S, Tamary H, Carmichael SL, Barnard MR, Michelson AD, Bussel JB. Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia. Blood. 2015 Sep 10; 126(11):1367-78.

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Sakurai Y, Fitch-Tewfik JL, Qiu Y, Ahn B, Myers DR, Tran R, Fay ME, Ding L, Spearman PW, Michelson AD, Flaumenhaft R, Lam WA. Platelet geometry sensing spatially regulates a-granule secretion to enable matrix self-deposition. Blood. 2015 Jul 23; 126(4):531-8.

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Morales-Tirado V, Sojka DK, Katzman SD, Lazarski CA, Finkelman FD, Urban JF, Fowell DJ. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 2010 Apr 29; 115(17):3498-507.

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Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, Skehan BM, Umetani J, Brautigam CA, Leong JM, Rosen MK. Hierarchical regulation of WASP/WAVE proteins. Mol Cell. 2008 Nov 07; 32(3):426-38.

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Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity. 2003 Jan; 18(1):141-54.

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Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54.

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