Wiskott-Aldrich Syndrome

"Wiskott-Aldrich Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.

Descriptor ID	D014923
MeSH Number(s)	C15.378.100.100.970 C15.378.463.960 C15.378.553.546.605.900 C16.320.099.970 C16.320.322.937 C20.673.627.900
Concept/Terms	Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Syndrome, Wiskott-Aldrich Wiskott Aldrich Syndrome Wiskott Syndrome Imd2 Immunodeficiency 2 Aldrich Syndrome Syndrome, Aldrich Eczema-Thrombocytopenia-Immunodeficiency Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Eczema-Thrombocytopenia-Immunodeficiency Syndromes Syndrome, Eczema-Thrombocytopenia-Immunodeficiency Syndromes, Eczema-Thrombocytopenia-Immunodeficiency

Below are MeSH descriptors whose meaning is more general than "Wiskott-Aldrich Syndrome".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Blood Coagulation Disorders [C15.378.100]
Blood Coagulation Disorders, Inherited [C15.378.100.100]
Wiskott-Aldrich Syndrome [C15.378.100.100.970]
Hemorrhagic Disorders [C15.378.463]
Wiskott-Aldrich Syndrome [C15.378.463.960]
Leukocyte Disorders [C15.378.553]
Leukopenia [C15.378.553.546]
Lymphopenia [C15.378.553.546.605]
Wiskott-Aldrich Syndrome [C15.378.553.546.605.900]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Blood Coagulation Disorders, Inherited [C16.320.099]
Wiskott-Aldrich Syndrome [C16.320.099.970]
Genetic Diseases, X-Linked [C16.320.322]
Wiskott-Aldrich Syndrome [C16.320.322.937]
Immune System Diseases [C20]
Immunologic Deficiency Syndromes [C20.673]
Lymphopenia [C20.673.627]
Wiskott-Aldrich Syndrome [C20.673.627.900]

Below are MeSH descriptors whose meaning is related to "Wiskott-Aldrich Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Wiskott-Aldrich Syndrome".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Wiskott-Aldrich Syndrome" by people in this website by year, and whether "Wiskott-Aldrich Syndrome" was a major or minor topic of these publications.

Bar chart showing 3 publications over 3 distinct years, with a maximum of 1 publications in 2008 and 2015 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Total
2008	1	1
2015	1	1
2023	1	1

Below are the most recent publications written about "Wiskott-Aldrich Syndrome" by people in Profiles.

Labrosse R, Chu JI, Armant MA, Everett JK, Pellin D, Kareddy N, Frelinger AL, Henderson LA, O'Connell AE, Biswas A, Coenen-van der Spek J, Miggelbrink A, Fiorini C, Adhikari H, Berry CC, Cantu VA, Fong J, Jaroslavsky J, Karadeniz DF, Li QZ, Reddy S, Roche AM, Zhu C, Whangbo JS, Dansereau C, Mackinnon B, Morris E, Koo SM, London WB, Baris S, Ozen A, Karakoc-Aydiner E, Despotovic JM, Forbes Satter LR, Saitoh A, Aizawa Y, King A, Nguyen MAT, Vu VDU, Snapper SB, Galy A, Notarangelo LD, Bushman FD, Williams DA, Pai SY. Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Blood. 2023 10 12; 142(15):1281-1296.

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Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. Allergy. 2017 Dec; 72(12):1916-1924.

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Gerrits AJ, Leven EA, Frelinger AL, Brigstocke SL, Berny-Lang MA, Mitchell WB, Revel-Vilk S, Tamary H, Carmichael SL, Barnard MR, Michelson AD, Bussel JB. Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia. Blood. 2015 Sep 10; 126(11):1367-78.

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Sakurai Y, Fitch-Tewfik JL, Qiu Y, Ahn B, Myers DR, Tran R, Fay ME, Ding L, Spearman PW, Michelson AD, Flaumenhaft R, Lam WA. Platelet geometry sensing spatially regulates a-granule secretion to enable matrix self-deposition. Blood. 2015 Jul 23; 126(4):531-8.

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Morales-Tirado V, Sojka DK, Katzman SD, Lazarski CA, Finkelman FD, Urban JF, Fowell DJ. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 2010 Apr 29; 115(17):3498-507.

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Padrick SB, Cheng HC, Ismail AM, Panchal SC, Doolittle LK, Kim S, Skehan BM, Umetani J, Brautigam CA, Leong JM, Rosen MK. Hierarchical regulation of WASP/WAVE proteins. Mol Cell. 2008 Nov 07; 32(3):426-38.

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Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity. 2003 Jan; 18(1):141-54.

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Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54.

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