Ventral Tegmental Area

"Ventral Tegmental Area" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A region in the MESENCEPHALON which is dorsomedial to the SUBSTANTIA NIGRA and ventral to the RED NUCLEUS. The mesocortical and mesolimbic dopaminergic systems originate here, including an important projection to the NUCLEUS ACCUMBENS. Overactivity of the cells in this area has been suspected to contribute to the positive symptoms of SCHIZOPHRENIA.

Descriptor ID	D017557
MeSH Number(s)	A08.186.211.132.659.413.875.820
Concept/Terms	Ventral Tegmental Area Ventral Tegmental Area Tegmental Area, Ventral Ventral Tegmental Area of Tsai Area Tegmentalis Ventralis Area Tegmentalis Ventrali Tegmentalis Ventrali, Area Tegmentalis Ventralis, Area

Below are MeSH descriptors whose meaning is more general than "Ventral Tegmental Area".

Anatomy [A]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Brain Stem [A08.186.211.132]
Mesencephalon [A08.186.211.132.659]
Cerebral Peduncle [A08.186.211.132.659.413]
Tegmentum Mesencephali [A08.186.211.132.659.413.875]
Ventral Tegmental Area [A08.186.211.132.659.413.875.820]

Below are MeSH descriptors whose meaning is related to "Ventral Tegmental Area".

Below are MeSH descriptors whose meaning is more specific than "Ventral Tegmental Area".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ventral Tegmental Area" by people in this website by year, and whether "Ventral Tegmental Area" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2010 and 2012 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	1	2
2011	1	0	1
2012	1	1	2
2013	1	0	1
2014	1	0	1
2015	2	0	2
2016	0	1	1
2020	0	1	1

Below are the most recent publications written about "Ventral Tegmental Area" by people in Profiles.

DeGroot SR, Zhao-Shea R, Chung L, Klenowski PM, Sun F, Molas S, Gardner PD, Li Y, Tapper AR. Midbrain Dopamine Controls Anxiety-like Behavior by Engaging Unique Interpeduncular Nucleus Microcircuitry. Biol Psychiatry. 2020 12 01; 88(11):855-866.

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Molas S, DeGroot SR, Zhao-Shea R, Tapper AR. Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis. Trends Pharmacol Sci. 2017 02; 38(2):169-180.

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Ngolab J, Liu L, Zhao-Shea R, Gao G, Gardner PD, Tapper AR. Functional Upregulation of ?4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. J Neurosci. 2015 Jun 03; 35(22):8570-8.

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Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770.

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Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8.

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Liu L, Zhao-Shea R, McIntosh JM, Tapper AR. Nicotinic acetylcholine receptors containing the ?6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons. Biochem Pharmacol. 2013 Oct 15; 86(8):1194-200.

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Liu L, Hendrickson LM, Guildford MJ, Zhao-Shea R, Gardner PD, Tapper AR. Nicotinic acetylcholine receptors containing the ?4 subunit modulate alcohol reward. Biol Psychiatry. 2013 Apr 15; 73(8):738-46.

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Liu L, Zhao-Shea R, McIntosh JM, Gardner PD, Tapper AR. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing ?4 and ?6 subunits. Mol Pharmacol. 2012 Apr; 81(4):541-8.

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Zhao-Shea R, Liu L, Soll LG, Improgo MR, Meyers EE, McIntosh JM, Grady SR, Marks MJ, Gardner PD, Tapper AR. Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area. Neuropsychopharmacology. 2011 Apr; 36(5):1021-32.

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Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, Dougherty DD, Kim BW, Lee MJ, Wu S, Lee S, Calhoun J, Hodge SM, Fava M, Rosen BR, Smoller JW, Gasic GP, Breiter HC. Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS One. 2010 Nov 29; 5(11):e13945.

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