"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
Descriptor ID |
D020552
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MeSH Number(s) |
E05.196.401.153.150 E05.301.300.100.150 E05.393.560.150 E05.940.560.150
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Concept/Terms |
Comet Assay- Comet Assay
- Assay, Comet
- Assays, Comet
- Comet Assays
- Gel Electrophoresis, Single-Cell
- Electrophoreses, Single-Cell Gel
- Electrophoresis, Single-Cell Gel
- Gel Electrophoreses, Single-Cell
- Gel Electrophoresis, Single Cell
- Single-Cell Gel Electrophoreses
- Single-Cell Gel Electrophoresis
- Electrophoresis, Gel, Single-Cell
Alkaline Comet Assay- Alkaline Comet Assay
- Alkaline Comet Assays
- Assay, Alkaline Comet
- Assays, Alkaline Comet
- Comet Assay, Alkaline
- Comet Assays, Alkaline
- Alkaline Single-Cell Gel Electrophoresis Assay
- Alkaline Single Cell Gel Electrophoresis Assay
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Below are MeSH descriptors whose meaning is more general than "Comet Assay".
Below are MeSH descriptors whose meaning is more specific than "Comet Assay".
This graph shows the total number of publications written about "Comet Assay" by people in this website by year, and whether "Comet Assay" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2008 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2013 | 0 | 3 | 3 |
2015 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Comet Assay" by people in Profiles.
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Zhao W, Jiang G, Bi C, Li Y, Liu J, Ye C, He H, Li L, Song D, Shao R. The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2a by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation. Oncotarget. 2015 Nov 10; 6(35):37871-94.
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Khatri M, Bello D, Pal AK, Woskie S, Gassert TH, Demokritou P, Gaines P. Toxicological effects of PM0.25-2.0 particles collected from a photocopy center in three human cell lines. Inhal Toxicol. 2013 Sep; 25(11):621-32.
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Khatri M, Bello D, Pal AK, Cohen JM, Woskie S, Gassert T, Lan J, Gu AZ, Demokritou P, Gaines P. Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell lines. Part Fibre Toxicol. 2013 Aug 22; 10:42.
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Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci. 2013 Aug; 16(8):1008-15.
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Chompoosor A, Saha K, Ghosh PS, Macarthy DJ, Miranda OR, Zhu ZJ, Arcaro KF, Rotello VM. The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small. 2010 Oct 18; 6(20):2246-9.
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Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 2008 Dec 10; 60(5):803-17.
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Tawar U, Bansal S, Shrimal S, Singh M, Tandon V. Nuclear condensation and free radical scavenging: a dual mechanism of bisbenzimidazoles to modulate radiation damage to DNA. Mol Cell Biochem. 2007 Nov; 305(1-2):221-33.