"Caspase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 7; CASPASE 8; and CASPASE 10. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053178
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| MeSH Number(s) |
D08.811.277.656.262.500.126.350.600 D08.811.277.656.300.200.126.350.600 D12.644.360.075.405.350.600 D12.776.476.075.405.350.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspase 6".
Below are MeSH descriptors whose meaning is more specific than "Caspase 6".
This graph shows the total number of publications written about "Caspase 6" by people in this website by year, and whether "Caspase 6" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Caspase 6" by people in Profiles.
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Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. 2021 09 21; 60(37):2824-2835.
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Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. 2019 12 31; 58(52):5320-5328.
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MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. J Biol Chem. 2019 01 04; 294(1):71-88.
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Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Sci Rep. 2018 03 13; 8(1):4428.
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Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E7977-E7986.
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Dagbay KB, Hill ME, Barrett E, Hardy JA. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. 2017 08 29; 56(34):4568-4577.
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Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. J Biol Chem. 2017 03 24; 292(12):4885-4897.
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Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 06 17; 11(6):1603-12.
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Zhang W, Xiao H, Parkin KL. Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite. Food Chem Toxicol. 2014 Jun; 68:1-10.
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Vel?zquez-Delgado EM, Hardy JA. Zinc-mediated allosteric inhibition of caspase-6. J Biol Chem. 2012 Oct 19; 287(43):36000-11.