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Craig Mello PhD

TitleDistinguished Professor
Endowed TitleBlais University Chair in Molecular Medicine
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
368 Plantation Street Suite AS5-2047
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentCancer Center

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentCancer Center

    Collapse Biography 
    Collapse education and training
    Brown University, Providence, RI, United StatesBSBiochemistry
    Harvard University, Cambridge, MA, United StatesPHDCellular/Developmental Biology

    Collapse Overview 
    Collapse overview

    Academic Background

    Blais University Chair in Molecular Medicine

    Dr. Craig C. Mello received his B.Sc. degree in Biochemistry from Brown University in 1982, and received his Ph.D. from Harvard University in 1990. From 1990 to 1994 he conducted postdoctoral research at the Fred Hutchinson Cancer Research Center in Seattle, WA. He has been a member of the University of Massachusetts Medical School faculty since 1995, and a Howard Hughes Medical Investigator since 2000. His pioneering research on RNAi, in collaboration with Dr. Andrew Fire, has been recognized with numerous awards culminating with the prestigious 2006 Nobel Prize in Physiology or Medicine.

    RNA-mediated Gene Regulation

    Photo: Craig Mello

    In much the same way that we use short search queries to navigate the World Wide Web, cells use short segments of genetic code to find and regulate matching information. The proteins that mediate these searches are highly conserved in plants and animals and are essential for viability and fertility. Craig Mello is investigating how these search mechanisms work and how organisms use them to regulate, share, and propagate genetic information.

    For more information about Dr. Mello's research, please visit his Howard Hughes Medical Institute page at:


    Collapse Rotation Projects

    Potential Rotation Projects:

    There are numerous potential rotation project available in the Mello lab:

    Projects include: Investigation of RNAi and related mechanisms, including Piwi Argonaute pathways and their affects on fertility and epigenetic inheritance; Investigation of germline determination and cell-fate specification during embryogenesis; the exploration of CRISPR mediated genome editing tools for C. elegans and other organisms; and finally the use of CRISPR to generate C. elegans models for human genetic disease.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang G, Zheng C, Ding YH, Mello C. Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4. Nat Commun. 2024 Mar 28; 15(1):2727. PMID: 38548791.
    2. Ding YH, Ochoa HJ, Ishidate T, Shirayama M, Mello CC. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Rep. 2023 05 30; 42(5):112408. PMID: 37083324.
      Citations: 3     Fields:    Translation:AnimalsCells
    3. Dai S, Tang X, Li L, Ishidate T, Ozturk AR, Chen H, Dude AL, Yan YH, Dong MQ, Shen EZ, Mello CC. A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing. Cell Rep. 2022 09 06; 40(10):111265. PMID: 36070689.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-P?rez JA, Sontheimer EJ, Watts JK, Mello CC. 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 2021 10 19; 10. PMID: 34665130.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    5. Makeyeva YV, Shirayama M, Mello CC. Cues from mRNA splicing prevent default Argonaute silencing in C.?elegans. Dev Cell. 2021 09 27; 56(18):2636-2648.e4. PMID: 34547227.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Ghanta KS, Ishidate T, Mello CC. Microinjection for precision genome editing in Caenorhabditis elegans. STAR Protoc. 2021 09 17; 2(3):100748. PMID: 34505086.
      Citations: 22     Fields:    Translation:Animals
    7. Kim H, Ding YH, Zhang G, Yan YH, Conte D, Dong MQ, Mello CC. HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans. Elife. 2021 05 18; 10. PMID: 34003109.
      Citations: 8     Fields:    Translation:AnimalsCells
    8. Kim H, Ding YH, Lu S, Zuo MQ, Tan W, Conte D, Dong MQ, Mello CC. PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans. Elife. 2021 05 18; 10. PMID: 34003111.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Chaves DA, Dai H, Li L, Moresco JJ, Oh ME, Conte D, Yates JR, Mello CC, Gu W. The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C.?elegans. Mol Cell. 2021 02 04; 81(3):546-557.e5. PMID: 33378643.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Ghanta KS, Mello CC. Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans. Genetics. 2020 11; 216(3):643-650. PMID: 32963112.
      Citations: 60     Fields:    Translation:AnimalsCells
    11. Dokshin GA, Davis GM, Sawle AD, Eldridge MD, Nicholls PK, Gourley TE, Romer KA, Molesworth LW, Tatnell HR, Ozturk AR, de Rooij DG, Hannon GJ, Page DC, Mello CC, Carmell MA. GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dev Cell. 2020 01 06; 52(1):53-68.e6. PMID: 31839538.
      Citations: 26     Fields:    Translation:AnimalsCells
    12. Dokshin GA, Ghanta KS, Piscopo KM, Mello CC. Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans. Genetics. 2018 11; 210(3):781-787. PMID: 30213854.
      Citations: 186     Fields:    Translation:AnimalsCells
    13. Ishidate T, Ozturk AR, Durning DJ, Sharma R, Shen EZ, Chen H, Seth M, Shirayama M, Mello CC. ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. Mol Cell. 2018 05 17; 70(4):639-649.e6. PMID: 29775580.
      Citations: 45     Fields:    Translation:AnimalsCells
    14. Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C.?elegans. Dev Cell. 2018 03 26; 44(6):762-770.e3. PMID: 29456136.
      Citations: 23     Fields:    Translation:AnimalsCells
    15. Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C.?elegans Germline. Cell. 2018 02 22; 172(5):937-951.e18. PMID: 29456082.
      Citations: 100     Fields:    Translation:AnimalsCells
    16. Seth M, Shirayama M, Tang W, Shen EZ, Tu S, Lee HC, Weng Z, Mello CC. The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C.?elegans. Cell Rep. 2018 02 27; 22(9):2254-2264. PMID: 29456100.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. Gammon DB, Ishidate T, Li L, Gu W, Silverman N, Mello CC. The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans. Curr Biol. 2017 Mar 20; 27(6):795-806. PMID: 28262484.
      Citations: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Tang W, Tu S, Lee HC, Weng Z, Mello CC. The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans. Cell. 2016 Feb 25; 164(5):974-84. PMID: 26919432.
      Citations: 69     Fields:    Translation:AnimalsCells
    19. Sharma U, Conine CC, Shea JM, Boskovic A, Derr AG, Bing XY, Belleannee C, Kucukural A, Serra RW, Sun F, Song L, Carone BR, Ricci EP, Li XZ, Fauquier L, Moore MJ, Sullivan R, Mello CC, Garber M, Rando OJ. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016 Jan 22; 351(6271):391-396. PMID: 26721685.
      Citations: 526     Fields:    Translation:AnimalsCells
    20. Hainer SJ, Gu W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG. Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes Dev. 2015 Feb 15; 29(4):362-78. PMID: 25691467.
      Citations: 46     Fields:    Translation:AnimalsCells
    21. Tsai HY, Chen CC, Conte D, Moresco JJ, Chaves DA, Mitani S, Yates JR, Tsai MD, Mello CC. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell. 2015 Jan 29; 160(3):407-19. PMID: 25635455.
      Citations: 40     Fields:    Translation:AnimalsCells
    22. Conte D, MacNeil LT, Walhout AJM, Mello CC. RNA Interference in Caenorhabditis elegans. Curr Protoc Mol Biol. 2015 Jan 05; 109:26.3.1-26.3.30. PMID: 25559107.
      Citations: 44     Fields:    Translation:Animals
    23. Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014 Jun 25; 3. PMID: 24966209.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Kim H, Ishidate T, Ghanta KS, Seth M, Conte D, Shirayama M, Mello CC. A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics. 2014 Aug; 197(4):1069-80. PMID: 24879462.
      Citations: 169     Fields:    Translation:AnimalsCells
    25. Ishidate T, Elewa A, Kim S, Mello CC, Shirayama M. Divide and differentiate: CDK/Cyclins and the art of development. Cell Cycle. 2014; 13(9):1384-91. PMID: 24675894.
      Citations: 19     Fields:    Translation:HumansAnimals
    26. Seth M, Shirayama M, Gu W, Ishidate T, Conte D, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23; 27(6):656-63. PMID: 24360782.
      Citations: 117     Fields:    Translation:AnimalsCells
    27. Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D, Yates JR, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19; 155(7):1532-44. PMID: 24360276.
      Citations: 90     Fields:    Translation:AnimalsCells
    28. Ishidate T, Kim S, Mello C, Shirayama M. Inductive asymmetric cell division: The WRM leads the way. Worm. 2013 Oct 01; 2(4):e26276. PMID: 24524013.
    29. Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):E918-27. PMID: 23431196.
      Citations: 16     Fields:    Translation:AnimalsCells
    30. Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D, Mello CC. CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell. 2012 Dec 21; 151(7):1488-500. PMID: 23260138.
      Citations: 128     Fields:    Translation:AnimalsCells
    31. D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep. 2012 Dec 27; 2(6):1537-45. PMID: 23200856.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    32. Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 06; 150(1):65-77. PMID: 22738726.
      Citations: 308     Fields:    Translation:AnimalsCells
    33. Lee HC, Gu W, Shirayama M, Youngman E, Conte D, Mello CC. C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell. 2012 Jul 06; 150(1):78-87. PMID: 22738724.
      Citations: 203     Fields:    Translation:AnimalsCells
    34. Thivierge C, Makil N, Flamand M, Vasale JJ, Mello CC, Wohlschlegel J, Conte D, Duchaine TF. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011 Dec 18; 19(1):90-7. PMID: 22179787.
      Citations: 31     Fields:    Translation:AnimalsCells
    35. Gu W, Claycomb JM, Batista PJ, Mello CC, Conte D. Cloning Argonaute-associated small RNAs from Caenorhabditis elegans. Methods Mol Biol. 2011; 725:251-80. PMID: 21528459.
      Citations: 14     Fields:    Translation:Animals
    36. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther. 2011 Mar; 19(3):526-35. PMID: 21179009.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    37. Conte D, Mello CC. Primal RNAs: The end of the beginning? Cell. 2010 Feb 19; 140(4):452-4. PMID: 20178736.
      Citations: 2     Fields:    Translation:AnimalsCells
    38. Conine CC, Batista PJ, Gu W, Claycomb JM, Chaves DA, Shirayama M, Mello CC. Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3588-93. PMID: 20133686.
      Citations: 129     Fields:    Translation:AnimalsCells
    39. Vasale JJ, Gu W, Thivierge C, Batista PJ, Claycomb JM, Youngman EM, Duchaine TF, Mello CC, Conte D. Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3582-7. PMID: 20133583.
      Citations: 112     Fields:    Translation:AnimalsCells
    40. Liu J, Maduzia LL, Shirayama M, Mello CC. NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. Dev Biol. 2010 Mar 15; 339(2):366-73. PMID: 20059995.
      Citations: 29     Fields:    Translation:AnimalsCells
    41. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Mello CC. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 02; 139(1):123-34. PMID: 19804758.
      Citations: 251     Fields:    Translation:Animals
    42. Gu W, Shirayama M, Conte D, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR, Mitani S, Carrington JC, Mello CC. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009 Oct 23; 36(2):231-44. PMID: 19800275.
      Citations: 289     Fields:    Translation:AnimalsCells
    43. Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, Kasschau KD, Chaves DA, Gu W, Vasale JJ, Duan S, Conte D, Luo S, Schroth GP, Carrington JC, Bartel DP, Mello CC. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell. 2008 Jul 11; 31(1):67-78. PMID: 18571452.
      Citations: 322     Fields:    Translation:AnimalsCells
    44. Mello CC. Return to the RNAi world: rethinking gene expression and evolution. Cell Death Differ. 2007 Dec; 14(12):2013-20. PMID: 18007672.
      Citations: 10     Fields:    Translation:Animals
    45. Mello CC. Return to the RNAi world: rethinking gene expression and evolution (Nobel Lecture). Angew Chem Int Ed Engl. 2007; 46(37):6985-94. PMID: 17712806.
      Citations: 11     Fields:    Translation:HumansAnimals
    46. Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell. 2006 Nov 17; 127(4):747-57. PMID: 17110334.
      Citations: 329     Fields:    Translation:AnimalsCells
    47. Hayakawa A, Leonard D, Murphy S, Hayes S, Soto M, Fogarty K, Standley C, Bellve K, Lambright D, Mello C, Corvera S. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11928-33. PMID: 16873553.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    48. Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006 Jan 27; 124(2):343-54. PMID: 16439208.
      Citations: 220     Fields:    Translation:AnimalsCells
    49. Shirayama M, Soto MC, Ishidate T, Kim S, Nakamura K, Bei Y, van den Heuvel S, Mello CC. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006 Jan 10; 16(1):47-55. PMID: 16343905.
      Citations: 47     Fields:    Translation:AnimalsCells
    50. Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. Genes Dev. 2005 Aug 01; 19(15):1749-54. PMID: 16077004.
      Citations: 44     Fields:    Translation:AnimalsCells
    51. Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28; 436(7050):593-7. PMID: 16049496.
      Citations: 150     Fields:    Translation:AnimalsCells
    52. Chen CC, Simard MJ, Tabara H, Brownell DR, McCollough JA, Mello CC. A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans. Curr Biol. 2005 Feb 22; 15(4):378-83. PMID: 15723801.
      Citations: 55     Fields:    Translation:AnimalsCells
    53. Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14955-60. PMID: 15469912.
      Citations: 23     Fields:    Translation:AnimalsCells
    54. Mello CC, Conte D. Revealing the world of RNA interference. Nature. 2004 Sep 16; 431(7006):338-42. PMID: 15372040.
      Citations: 310     Fields:    Translation:AnimalsCells
    55. Hutv?gner G, Simard MJ, Mello CC, Zamore PD. Sequence-specific inhibition of small RNA function. PLoS Biol. 2004 Apr; 2(4):E98. PMID: 15024405.
      Citations: 264     Fields:    Translation:HumansAnimalsCells
    56. Pang KM, Ishidate T, Nakamura K, Shirayama M, Trzepacz C, Schubert CM, Priess JR, Mello CC. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Dev Biol. 2004 Jan 01; 265(1):127-39. PMID: 14697358.
      Citations: 27     Fields:    Translation:AnimalsCells
    57. Venkatesan K, McManus HR, Mello CC, Smith TF, Hansen U. Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. Nucleic Acids Res. 2003 Aug 01; 31(15):4304-16. PMID: 12888489.
      Citations: 44     Fields:    Translation:AnimalsCells
    58. Conte D, Mello CC. RNA interference in Caenorhabditis elegans. Curr Protoc Mol Biol. 2003 May; Chapter 26:Unit 26.3. PMID: 18265327.
      Citations: 6     Fields:    Translation:AnimalsCells
    59. Unhavaithaya Y, Shin TH, Miliaras N, Lee J, Oyama T, Mello CC. MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans. Cell. 2002 Dec 27; 111(7):991-1002. PMID: 12507426.
      Citations: 96     Fields:    Translation:AnimalsCells
    60. Bei Y, Hogan J, Berkowitz LA, Soto M, Rocheleau CE, Pang KM, Collins J, Mello CC. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002 Jul; 3(1):113-25. PMID: 12110172.
      Citations: 74     Fields:    Translation:AnimalsCells
    61. Tabara H, Yigit E, Siomi H, Mello CC. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002 Jun 28; 109(7):861-71. PMID: 12110183.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    62. Soto MC, Qadota H, Kasuya K, Inoue M, Tsuboi D, Mello CC, Kaibuchi K. The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev. 2002 Mar 01; 16(5):620-32. PMID: 11877381.
      Citations: 65     Fields:    Translation:AnimalsCells
    63. Grishok A, Mello CC. RNAi (Nematodes: Caenorhabditis elegans). Adv Genet. 2002; 46:339-60. PMID: 11931230.
      Citations: 24     Fields:    Translation:AnimalsCells
    64. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. PMID: 11461699.
      Citations: 763     Fields:    Translation:Animals
    65. Grishok A, Tabara H, Mello CC. Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000 Mar 31; 287(5462):2494-7. PMID: 10741970.
      Citations: 150     Fields:    Translation:AnimalsCells
    66. Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999 Oct 15; 99(2):123-32. PMID: 10535731.
      Citations: 444     Fields:    Translation:AnimalsCells
    67. Shin TH, Yasuda J, Rocheleau CE, Lin R, Soto M, Bei Y, Davis RJ, Mello CC. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Mol Cell. 1999 Aug; 4(2):275-80. PMID: 10488343.
      Citations: 44     Fields:    Translation:AnimalsCells
    68. Rocheleau CE, Yasuda J, Shin TH, Lin R, Sawa H, Okano H, Priess JR, Davis RJ, Mello CC. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999 Jun 11; 97(6):717-26. PMID: 10380924.
      Citations: 105     Fields:    Translation:AnimalsCells
    69. Tabara H, Grishok A, Mello CC. RNAi in C. elegans: soaking in the genome sequence. Science. 1998 Oct 16; 282(5388):430-1. PMID: 9841401.
      Citations: 150     Fields:    Translation:AnimalsCells
    70. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998 Feb 19; 391(6669):806-11. PMID: 9486653.
      Citations: 4341     Fields:    Translation:AnimalsCells
    71. Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR, Mello CC. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997 Aug 22; 90(4):707-16. PMID: 9288750.
      Citations: 197     Fields:    Translation:AnimalsCells
    72. Mello CC, Schubert C, Draper B, Zhang W, Lobel R, Priess JR. The PIE-1 protein and germline specification in C. elegans embryos. Nature. 1996 Aug 22; 382(6593):710-2. PMID: 8751440.
      Citations: 109     Fields:    Translation:AnimalsCells
    73. Seydoux G, Mello CC, Pettitt J, Wood WB, Priess JR, Fire A. Repression of gene expression in the embryonic germ lineage of C. elegans. Nature. 1996 Aug 22; 382(6593):713-6. PMID: 8751441.
      Citations: 97     Fields:    Translation:AnimalsCells
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