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Lisa A Lewis PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8587
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology


    Collapse Biography 
    Collapse education and training
    Clemson University, Clemson, SC, United StatesBSMicrobiology
    State University of New York, Buffalo, Buffalo, NY, United StatesMAMicrobiology
    State University of New York, Buffalo, Buffalo, NY, United StatesPHDMicrobiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of anti-gonococcal CMP-nonulosonate therapeutics require cathelicidins. J Infect Dis. 2020 Jul 21. PMID: 32692363.
      View in: PubMed
    2. Gulati S, Schoenhofen IC, Lindhout-Djukic T, Schur MJ, Landig CS, Saha S, Deng L, Lewis LA, Zheng B, Varki A, Ram S. Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae. J Immunol. 2020 May 20. PMID: 32434942.
      View in: PubMed
    3. Lewis LA, Ram S. Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states and evasion mechanisms. FEBS Lett. 2020 Feb 14. PMID: 32058583.
      View in: PubMed
    4. Lewis LA, Panicker S, DeOliveira RB, Parry GC, Ram S. Effect of a C1s Inhibitor on the Efficacy of Anti-Capsular Antibodies against Neisseria meningitidis and Streptococcus pneumoniae. Immunohorizons. 2019 Nov 05; 3(11):519-530. PMID: 31690560.
      View in: PubMed
    5. Beernink PT, Vianzon V, Lewis LA, Moe GR, Granoff DM. A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine. MBio. 2019 Jun 18; 10(3). PMID: 31213564.
      View in: PubMed
    6. Lewis LA, Rice PA, Ram S. The role of gonococcal Neisserial surface protein A (NspA) in serum resistance and comparison of its factor H binding properties with that of its meningococcal counterpart. Infect Immun. 2018 Dec 03. PMID: 30510105.
      View in: PubMed
    7. Beernink PT, Ispasanie E, Lewis LA, Ram S, Moe GR, Granoff DM. A meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and overexpressed Factor H binding protein elicits gonococcal bactericidal antibodies. J Infect Dis. 2018 Oct 20. PMID: 30346576.
      View in: PubMed
    8. Shaughnessy J, Lewis LA, Zheng B, Carr C, Bass I, Gulati S, DeOliveira RB, Gose S, Reed GW, Botto M, Rice PA, Ram S. Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae. J Immunol. 2018 Sep 28. PMID: 30266769.
      View in: PubMed
    9. Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, Rice PA. A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity. Infect Immun. 2018 May 29. PMID: 29844237.
      View in: PubMed
    10. Ram S, Shaughnessy J, de Oliveira RB, Lewis LA, Gulati S, Rice PA. Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics. Pathog Dis. 2017 Jun 01; 75(4). PMID: 28460033.
      View in: PubMed
    11. Ram S, Shaughnessy J, DeOliveira RB, Lewis LA, Gulati S, Rice PA. Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. Immunobiology. 2016 Oct; 221(10):1110-23. PMID: 27297292.
      View in: PubMed
    12. Chakraborti S, Lewis LA, Cox AD, St Michael F, Li J, Rice PA, Ram S. Phase-Variable Heptose I Glycan Extensions Modulate Efficacy of 2C7 Vaccine Antibody Directed against Neisseria gonorrhoeae Lipooligosaccharide. J Immunol. 2016 Jun 1; 196(11):4576-86. PMID: 27183633.
      View in: PubMed
    13. Shaughnessy J, Gulati S, Agarwal S, Unemo M, Ohnishi M, Su XH, Monks BG, Visintin A, Madico G, Lewis LA, Golenbock DT, Reed GW, Rice PA, Ram S. A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae. J Immunol. 2016 Feb 15; 196(4):1732-40. PMID: 26773149.
      View in: PubMed
    14. Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, Reed GW, Varki A, Rice PA, Ram S. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. PLoS Pathog. 2015 Dec; 11(12):e1005290. PMID: 26630657.
      View in: PubMed
    15. Lewis LA, Gulati S, Burrowes E, Zheng B, Ram S, Rice PA. a-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract. MBio. 2015 Feb 03; 6(1). PMID: 25650401.
      View in: PubMed
    16. Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, Mueller JP. Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2015 Mar; 59(3):1478-86. PMID: 25534723.
      View in: PubMed
    17. Lewis LA, Vu DM, Granoff DM, Ram S. Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infect Immun. 2014 Jun; 82(6):2574-84. PMID: 24686052.
      View in: PubMed
    18. Lewis LA, Vu DM, Vasudhev S, Shaughnessy J, Granoff DM, Ram S. Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis. MBio. 2013 Oct 15; 4(5):e00339-13. PMID: 24129254.
      View in: PubMed
    19. Lewis LA, Ram S. Meningococcal disease and the complement system. Virulence. 2014 Jan 1; 5(1):98-126. PMID: 24104403.
      View in: PubMed
    20. Gulati S, Zheng B, Reed GW, Su X, Cox AD, St Michael F, Stupak J, Lewis LA, Ram S, Rice PA. Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection. PLoS Pathog. 2013; 9(8):e1003559. PMID: 24009500.
      View in: PubMed
    21. Lewis LA, Shafer WM, Dutta Ray T, Ram S, Rice PA. Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing. Infect Immun. 2013 Jan; 81(1):33-42. PMID: 23071134.
      View in: PubMed
    22. Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P. The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation. Infect Immun. 2012 Oct; 80(10):3417-28. PMID: 22825445.
      View in: PubMed
    23. Lewis LA, Carter M, Ram S. The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci. J Immunol. 2012 May 15; 188(10):5063-72. PMID: 22504643.
      View in: PubMed
    24. Vu DM, Shaughnessy J, Lewis LA, Ram S, Rice PA, Granoff DM. Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Infect Immun. 2012 Feb; 80(2):643-50. PMID: 22104107.
      View in: PubMed
    25. Ray TD, Lewis LA, Gulati S, Rice PA, Ram S. Novel blocking human IgG directed against the pentapeptide repeat motifs of Neisseria meningitidis Lip/H.8 and Laz lipoproteins. J Immunol. 2011 Apr 15; 186(8):4881-94. PMID: 21402895.
      View in: PubMed
    26. Ram S, Lewis LA, Agarwal S. Meningococcal group W-135 and Y capsular polysaccharides paradoxically enhance activation of the alternative pathway of complement. J Biol Chem. 2011 Mar 11; 286(10):8297-307. PMID: 21245150.
      View in: PubMed
    27. Ram S, Lewis LA, Rice PA. Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev. 2010 Oct; 23(4):740-80. PMID: 20930072.
      View in: PubMed
    28. Lewis LA, Ngampasutadol J, Wallace R, Reid JE, Vogel U, Ram S. The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement. PLoS Pathog. 2010 Jul 29; 6(7):e1001027. PMID: 20686663.
      View in: PubMed
    29. Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Aricò B. Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3770-5. PMID: 20133713.
      View in: PubMed
    30. Shaughnessy J, Lewis LA, Jarva H, Ram S. Functional comparison of the binding of factor H short consensus repeat 6 (SCR 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin. Infect Immun. 2009 May; 77(5):2094-103. PMID: 19273554.
      View in: PubMed
    31. Lewis LA, Choudhury B, Balthazar JT, Martin LE, Ram S, Rice PA, Stephens DS, Carlson R, Shafer WM. Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum. Infect Immun. 2009 Mar; 77(3):1112-20. PMID: 19114544.
      View in: PubMed
    32. Lewis LA, Ram S, Prasad A, Gulati S, Getzlaff S, Blom AM, Vogel U, Rice PA. Defining targets for complement components C4b and C3b on the pathogenic neisseriae. Infect Immun. 2008 Jan; 76(1):339-50. PMID: 17984207.
      View in: PubMed
    33. Ram S, Ngampasutadol J, Cox AD, Blom AM, Lewis LA, St Michael F, Stupak J, Gulati S, Rice PA. Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance. Infect Immun. 2007 Aug; 75(8):4071-81. PMID: 17526744.
      View in: PubMed
    34. Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 1; 177(1):501-10. PMID: 16785547.
      View in: PubMed
    35. Gulati S, Cox A, Lewis LA, Michael FS, Li J, Boden R, Ram S, Rice PA. Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci. Infect Immun. 2005 Nov; 73(11):7390-7. PMID: 16239538.
      View in: PubMed
    36. Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson RS. Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20. J Bacteriol. 2005 Jul; 187(13):4627-36. PMID: 15968074.
      View in: PubMed
    37. Munson RS, Harrison A, Gillaspy A, Ray WC, Carson M, Armbruster D, Gipson J, Gipson M, Johnson L, Lewis L, Dyer DW, Bakaletz LO. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates. Infect Immun. 2004 May; 72(5):3002-10. PMID: 15102813.
      View in: PubMed
    38. Williams WA, Hendrickson A, Gillaspy AF, Dyer DW, Lewis LA. Oligonucleotide analysis by sequential injection before analysis (SIBA) capillary electrophoresis. Anal Biochem. 2003 Feb 1; 313(1):183-5. PMID: 12576078.
      View in: PubMed
    39. Rohde KH, Gillaspy AF, Hatfield MD, Lewis LA, Dyer DW. Interactions of haemoglobin with the Neisseria meningitidis receptor HpuAB: the role of TonB and an intact proton motive force. Mol Microbiol. 2002 Jan; 43(2):335-54. PMID: 11985713.
      View in: PubMed
    40. Lewis LA, Gipson M, Hartman K, Ownbey T, Vaughn J, Dyer DW. Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2. Mol Microbiol. 1999 Jun; 32(5):977-89. PMID: 10361300.
      View in: PubMed
    41. Lewis LA, Sung MH, Gipson M, Hartman K, Dyer DW. Transport of intact porphyrin by HpuAB, the hemoglobin-haptoglobin utilization system of Neisseria meningitidis. J Bacteriol. 1998 Nov; 180(22):6043-7. PMID: 9811666.
      View in: PubMed
    42. Lewis LA, Rohde K, Gipson M, Behrens B, Gray E, Toth SI, Roe BA, Dyer DW. Identification and molecular analysis of lbpBA, which encodes the two-component meningococcal lactoferrin receptor. Infect Immun. 1998 Jun; 66(6):3017-23. PMID: 9596785.
      View in: PubMed
    43. Lewis LA, Gray E, Wang YP, Roe BA, Dyer DW. Molecular characterization of hpuAB, the haemoglobin-haptoglobin-utilization operon of Neisseria meningitidis. Mol Microbiol. 1997 Feb; 23(4):737-49. PMID: 9157245.
      View in: PubMed
    44. Chen CJ, Sparling PF, Lewis LA, Dyer DW, Elkins C. Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae. Infect Immun. 1996 Dec; 64(12):5008-14. PMID: 8945539.
      View in: PubMed
    45. Lewis LA, Dyer DW. Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin. J Bacteriol. 1995 Mar; 177(5):1299-306. PMID: 7868605.
      View in: PubMed
    46. Quinn ML, Weyer SJ, Lewis LA, Dyer DW, Wagner PM. Insertional inactivation of the gene for the meningococcal lactoferrin binding protein. Microb Pathog. 1994 Oct; 17(4):227-37. PMID: 7715421.
      View in: PubMed
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