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Lisa A Lewis PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-8587
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases


    Collapse Biography 
    Collapse education and training
    Clemson University, Clemson, SC, United StatesBSMicrobiology
    State University of New York, Buffalo, Buffalo, NY, United StatesMAMicrobiology
    State University of New York, Buffalo, Buffalo, NY, United StatesPHDMicrobiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gulati S, Mattsson AH, Schussek S, Zheng B, DeOliveira RB, Shaughnessy J, Lewis LA, Rice PA, Comstedt P, Ram S. Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence. mBio. 2023 Oct 31; e0250023. PMID: 37905891.
      Citations: 1     Fields:    
    2. Su X, Le W, Zhu X, Li S, Wang B, Madico G, Yang Z, Chaisson CE, McLaughlin RE, Gandra S, Yoon J, Zheng B, Lewis LA, Gulati S, Reed GW, Ram S, Rice PA. Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden. J Infect Dis. 2022 12 13; 226(12):2192-2203. PMID: 36201640.
      Citations: 2     Fields:    Translation:HumansCells
    3. Shaughnessy J, Chabeda A, Lewis LA, Ram S. Alternative pathway amplification and infections. Immunol Rev. 2023 01; 313(1):162-180. PMID: 36336911.
      Citations: 2     Fields:    Translation:Humans
    4. Shaughnessy J, Chabeda A, Tran Y, Zheng B, Nowak N, Steffens C, DeOliveira RB, Gulati S, Lewis LA, Maclean J, Moss JA, Wycoff KL, Ram S. An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae. Front Immunol. 2022; 13:975676. PMID: 36110842.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Lewis LA, Gulati S, Zelek WM, Morgan BP, Song WC, Zheng B, Nowak N, DeOliveira RB, Sanchez B, DeSouza Silva L, Schuurman J, Beurskens F, Ram S, Rice PA. Efficacy of an Experimental Gonococcal Lipooligosaccharide Mimitope Vaccine Requires Terminal Complement. J Infect Dis. 2022 05 16; 225(10):1861-1864. PMID: 34971376.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Gulati S, Schoenhofen IC, Lindhout-Djukic T, Lewis LA, Moustafa IY, Saha S, Zheng B, Nowak N, Rice PA, Varki A, Ram S. Efficacy of Antigonococcal CMP-Nonulosonate Therapeutics Require Cathelicidins. J Infect Dis. 2020 10 13; 222(10):1641-1650. PMID: 32692363.
      Citations: 8     Fields:    Translation:AnimalsCells
    7. Gulati S, Schoenhofen IC, Lindhout-Djukic T, Schur MJ, Landig CS, Saha S, Deng L, Lewis LA, Zheng B, Varki A, Ram S. Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae. J Immunol. 2020 06 15; 204(12):3283-3295. PMID: 32434942.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Lewis LA, Ram S. Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states, and evasion mechanisms. FEBS Lett. 2020 08; 594(16):2670-2694. PMID: 32058583.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    9. Lewis LA, Panicker S, DeOliveira RB, Parry GC, Ram S. Effect of a C1s Inhibitor on the Efficacy of Anti-Capsular Antibodies against Neisseria meningitidis and Streptococcus pneumoniae. Immunohorizons. 2019 11 05; 3(11):519-530. PMID: 31690560.
      Citations: 4     Fields:    Translation:HumansCells
    10. Beernink PT, Vianzon V, Lewis LA, Moe GR, Granoff DM. A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine. mBio. 2019 06 18; 10(3). PMID: 31213564.
      Citations: 16     Fields:    Translation:AnimalsCells
    11. Beernink PT, Ispasanie E, Lewis LA, Ram S, Moe GR, Granoff DM. A Meningococcal Native Outer Membrane Vesicle Vaccine With Attenuated Endotoxin and Overexpressed Factor H Binding Protein Elicits Gonococcal Bactericidal Antibodies. J Infect Dis. 2019 03 15; 219(7):1130-1137. PMID: 30346576.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    12. Lewis LA, Rice PA, Ram S. Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart. Infect Immun. 2019 02; 87(2). PMID: 30510105.
      Citations: 17     Fields:    Translation:HumansCells
    13. Shaughnessy J, Lewis LA, Zheng B, Carr C, Bass I, Gulati S, DeOliveira RB, Gose S, Reed GW, Botto M, Rice PA, Ram S. Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae. J Immunol. 2018 11 01; 201(9):2700-2709. PMID: 30266769.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, Rice PA. A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity. Infect Immun. 2018 08; 86(8). PMID: 29844237.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Ram S, Shaughnessy J, de Oliveira RB, Lewis LA, Gulati S, Rice PA. Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics. Pathog Dis. 2017 06 01; 75(4). PMID: 28460033.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Ram S, Shaughnessy J, DeOliveira RB, Lewis LA, Gulati S, Rice PA. Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae. Immunobiology. 2016 10; 221(10):1110-23. PMID: 27297292.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    17. Chakraborti S, Lewis LA, Cox AD, St Michael F, Li J, Rice PA, Ram S. Phase-Variable Heptose I Glycan Extensions Modulate Efficacy of 2C7 Vaccine Antibody Directed against Neisseria gonorrhoeae Lipooligosaccharide. J Immunol. 2016 06 01; 196(11):4576-86. PMID: 27183633.
      Citations: 21     Fields:    Translation:HumansCells
    18. Shaughnessy J, Gulati S, Agarwal S, Unemo M, Ohnishi M, Su XH, Monks BG, Visintin A, Madico G, Lewis LA, Golenbock DT, Reed GW, Rice PA, Ram S. A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae. J Immunol. 2016 Feb 15; 196(4):1732-40. PMID: 26773149.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    19. Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, Reed GW, Varki A, Rice PA, Ram S. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. PLoS Pathog. 2015 Dec; 11(12):e1005290. PMID: 26630657.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    20. Lewis LA, Gulati S, Burrowes E, Zheng B, Ram S, Rice PA. a-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract. mBio. 2015 Feb 03; 6(1). PMID: 25650401.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    21. Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, Mueller JP. Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2015 Mar; 59(3):1478-86. PMID: 25534723.
      Citations: 36     Fields:    Translation:Cells
    22. Lewis LA, Vu DM, Granoff DM, Ram S. Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infect Immun. 2014 Jun; 82(6):2574-84. PMID: 24686052.
      Citations: 12     Fields:    Translation:AnimalsCells
    23. Lewis LA, Vu DM, Vasudhev S, Shaughnessy J, Granoff DM, Ram S. Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis. mBio. 2013 Oct 15; 4(5):e00339-13. PMID: 24129254.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    24. Lewis LA, Ram S. Meningococcal disease and the complement system. Virulence. 2014 Jan 01; 5(1):98-126. PMID: 24104403.
      Citations: 80     Fields:    Translation:HumansCells
    25. Gulati S, Zheng B, Reed GW, Su X, Cox AD, St Michael F, Stupak J, Lewis LA, Ram S, Rice PA. Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection. PLoS Pathog. 2013; 9(8):e1003559. PMID: 24009500.
      Citations: 43     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    26. Lewis LA, Shafer WM, Dutta Ray T, Ram S, Rice PA. Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing. Infect Immun. 2013 Jan; 81(1):33-42. PMID: 23071134.
      Citations: 28     Fields:    Translation:HumansCells
    27. Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P. The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation. Infect Immun. 2012 Oct; 80(10):3417-28. PMID: 22825445.
      Citations: 12     Fields:    Translation:HumansCells
    28. Lewis LA, Carter M, Ram S. The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci. J Immunol. 2012 May 15; 188(10):5063-72. PMID: 22504643.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    29. Vu DM, Shaughnessy J, Lewis LA, Ram S, Rice PA, Granoff DM. Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Infect Immun. 2012 Feb; 80(2):643-50. PMID: 22104107.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    30. Ray TD, Lewis LA, Gulati S, Rice PA, Ram S. Novel blocking human IgG directed against the pentapeptide repeat motifs of Neisseria meningitidis Lip/H.8 and Laz lipoproteins. J Immunol. 2011 Apr 15; 186(8):4881-94. PMID: 21402895.
      Citations: 25     Fields:    Translation:HumansCells
    31. Ram S, Lewis LA, Agarwal S. Meningococcal group W-135 and Y capsular polysaccharides paradoxically enhance activation of the alternative pathway of complement. J Biol Chem. 2011 Mar 11; 286(10):8297-8307. PMID: 21245150.
      Citations: 14     Fields:    Translation:HumansCells
    32. Ram S, Lewis LA, Rice PA. Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev. 2010 Oct; 23(4):740-80. PMID: 20930072.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    33. Lewis LA, Ngampasutadol J, Wallace R, Reid JE, Vogel U, Ram S. The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement. PLoS Pathog. 2010 Jul 29; 6(7):e1001027. PMID: 20686663.
      Citations: 94     Fields:    Translation:HumansCells
    34. Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Aric? B. Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3770-5. PMID: 20133713.
      Citations: 85     Fields:    Translation:HumansCells
    35. Shaughnessy J, Lewis LA, Jarva H, Ram S. Functional comparison of the binding of factor H short consensus repeat 6 (SCR 6) to factor H binding protein from Neisseria meningitidis and the binding of factor H SCR 18 to 20 to Neisseria gonorrhoeae porin. Infect Immun. 2009 May; 77(5):2094-103. PMID: 19273554.
      Citations: 23     Fields:    Translation:HumansCells
    36. Lewis LA, Choudhury B, Balthazar JT, Martin LE, Ram S, Rice PA, Stephens DS, Carlson R, Shafer WM. Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum. Infect Immun. 2009 Mar; 77(3):1112-20. PMID: 19114544.
      Citations: 61     Fields:    Translation:HumansCells
    37. Lewis LA, Ram S, Prasad A, Gulati S, Getzlaff S, Blom AM, Vogel U, Rice PA. Defining targets for complement components C4b and C3b on the pathogenic neisseriae. Infect Immun. 2008 Jan; 76(1):339-50. PMID: 17984207.
      Citations: 28     Fields:    Translation:HumansCells
    38. Ram S, Ngampasutadol J, Cox AD, Blom AM, Lewis LA, St Michael F, Stupak J, Gulati S, Rice PA. Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance. Infect Immun. 2007 Aug; 75(8):4071-81. PMID: 17526744.
      Citations: 16     Fields:    Translation:HumansCells
    39. Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 01; 177(1):501-10. PMID: 16785547.
      Citations: 207     Fields:    Translation:HumansCells
    40. Gulati S, Cox A, Lewis LA, Michael FS, Li J, Boden R, Ram S, Rice PA. Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci. Infect Immun. 2005 Nov; 73(11):7390-7. PMID: 16239538.
      Citations: 39     Fields:    Translation:HumansCells
    41. Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson RS. Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20. J Bacteriol. 2005 Jul; 187(13):4627-36. PMID: 15968074.
      Citations: 132     Fields:    Translation:HumansCells
    42. Munson RS, Harrison A, Gillaspy A, Ray WC, Carson M, Armbruster D, Gipson J, Gipson M, Johnson L, Lewis L, Dyer DW, Bakaletz LO. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates. Infect Immun. 2004 May; 72(5):3002-10. PMID: 15102813.
      Citations: 23     Fields:    Translation:HumansCells
    43. Williams WA, Hendrickson A, Gillaspy AF, Dyer DW, Lewis LA. Oligonucleotide analysis by sequential injection before analysis (SIBA) capillary electrophoresis. Anal Biochem. 2003 Feb 01; 313(1):183-5. PMID: 12576078.
      Citations: 1     Fields:    
    44. Rohde KH, Gillaspy AF, Hatfield MD, Lewis LA, Dyer DW. Interactions of haemoglobin with the Neisseria meningitidis receptor HpuAB: the role of TonB and an intact proton motive force. Mol Microbiol. 2002 Jan; 43(2):335-54. PMID: 11985713.
      Citations: 19     Fields:    Translation:Cells
    45. Lewis LA, Gipson M, Hartman K, Ownbey T, Vaughn J, Dyer DW. Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2. Mol Microbiol. 1999 Jun; 32(5):977-89. PMID: 10361300.
      Citations: 42     Fields:    Translation:Cells
    46. Lewis LA, Sung MH, Gipson M, Hartman K, Dyer DW. Transport of intact porphyrin by HpuAB, the hemoglobin-haptoglobin utilization system of Neisseria meningitidis. J Bacteriol. 1998 Nov; 180(22):6043-7. PMID: 9811666.
      Citations: 21     Fields:    Translation:Cells
    47. Lewis LA, Rohde K, Gipson M, Behrens B, Gray E, Toth SI, Roe BA, Dyer DW. Identification and molecular analysis of lbpBA, which encodes the two-component meningococcal lactoferrin receptor. Infect Immun. 1998 Jun; 66(6):3017-23. PMID: 9596785.
      Citations: 13     Fields:    Translation:Cells
    48. Lewis LA, Gray E, Wang YP, Roe BA, Dyer DW. Molecular characterization of hpuAB, the haemoglobin-haptoglobin-utilization operon of Neisseria meningitidis. Mol Microbiol. 1997 Feb; 23(4):737-49. PMID: 9157245.
      Citations: 67     Fields:    Translation:Cells
    49. Chen CJ, Sparling PF, Lewis LA, Dyer DW, Elkins C. Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae. Infect Immun. 1996 Dec; 64(12):5008-14. PMID: 8945539.
      Citations: 38     Fields:    Translation:Cells
    50. Lewis LA, Dyer DW. Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin. J Bacteriol. 1995 Mar; 177(5):1299-306. PMID: 7868605.
      Citations: 48     Fields:    Translation:Cells
    51. Quinn ML, Weyer SJ, Lewis LA, Dyer DW, Wagner PM. Insertional inactivation of the gene for the meningococcal lactoferrin binding protein. Microb Pathog. 1994 Oct; 17(4):227-37. PMID: 7715421.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
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