Loading...
Header Logo
Keywords
Last Name
Institution

Charles A Specht PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-4721
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology


    Collapse Biography 
    Collapse education and training
    University of Vermont, Burlington, VT, United StatesBSScience
    University of Vermont, Burlington, VT, United StatesPHDPhilosophy

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hester MM, Lee CK, Abraham A, Khoshkenar P, Ostroff GR, Levitz SM, Specht CA. Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens. Vaccine. 2019 Nov 04. PMID: 31699504.
      View in: PubMed
    2. Lam WC, Upadhya R, Specht CA, Ragsdale AE, Hole CR, Levitz SM, Lodge JK. Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii. mSphere. 2019 Oct 09; 4(5). PMID: 31597720.
      View in: PubMed
    3. Akilimali NA, Muema DM, Specht C, Chang CC, Moosa MS, Levitz SM, Lewin SR, French MA, Ndung'u T. Cryptococcosis-associated Immune Reconstitution Inflammatory Syndrome is associated with Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T-cells and Monocyte Activation. J Acquir Immune Defic Syndr. 2019 Jan 08. PMID: 30649031.
      View in: PubMed
    4. Upadhya R, Baker LG, Lam WC, Specht CA, Donlin MJ, Lodge JK. Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis. MBio. 2018 Nov 20; 9(6). PMID: 30459196.
      View in: PubMed
    5. Deepe GS, Buesing WR, Ostroff GR, Abraham A, Specht CA, Huang H, Levitz SM. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. Vaccine. 2018 05 31; 36(23):3359-3367. PMID: 29729993.
      View in: PubMed
    6. Specht CA, Lee CK, Huang H, Hester MM, Liu J, Luckie BA, Torres Santana MA, Mirza Z, Khoshkenar P, Abraham A, Shen ZT, Lodge JK, Akalin A, Homan J, Ostroff GR, Levitz SM. Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. MBio. 2017 Nov 28; 8(6). PMID: 29184017.
      View in: PubMed
    7. Guerra ES, Lee CK, Specht CA, Yadav B, Huang H, Akalin A, Huh JR, Mueller C, Levitz SM. Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog. 2017 Jan 17; 13(1):e1006175. PMID: 28095479.
      View in: PubMed
    8. Upadhya R, Lam WC, Maybruck B, Specht CA, Levitz SM, Lodge JK. Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans. MBio. 2016 May 10; 7(3). PMID: 27165801.
      View in: PubMed
    9. Specht CA, Lee CK, Huang H, Tipper DJ, Shen ZT, Lodge JK, Leszyk J, Ostroff GR, Levitz SM. Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts. MBio. 2015 Dec 22; 6(6):e01905-15. PMID: 26695631.
      View in: PubMed
    10. Varlotto J, DiMaio C, Grassberger C, Tangel M, Mackley H, Pavelic M, Specht C, Sogge S, Nguyen D, Glantz M, Saw C, Upadhyay U, Moser R, Yunus S, Rava P, Fitzgerald T, Glanzman J, Sheehan J. Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes. Neurooncol Pract. 2016 Sep; 3(3):173-187. PMID: 31386091.
      View in: PubMed
    11. Wiesner DL, Specht CA, Lee CK, Smith KD, Mukaremera L, Lee ST, Lee CG, Elias JA, Nielsen JN, Boulware DR, Bohjanen PR, Jenkins MK, Levitz SM, Nielsen K. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog. 2015 Mar; 11(3):e1004701. PMID: 25764512.
      View in: PubMed
    12. Chaudhari SS, Noh MY, Moussian B, Specht CA, Kramer KJ, Beeman RW, Arakane Y, Muthukrishnan S. Knickkopf and retroactive proteins are required for formation of laminar serosal procuticle during embryonic development of Tribolium castaneum. Insect Biochem Mol Biol. 2015 May; 60:1-6. PMID: 25747009.
      View in: PubMed
    13. Loures FV, Röhm M, Lee CK, Santos E, Wang JP, Specht CA, Calich VL, Urban CF, Levitz SM. Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps. PLoS Pathog. 2015 Feb; 11(2):e1004643. PMID: 25659141.
      View in: PubMed
    14. Levitz SM, Huang H, Ostroff GR, Specht CA. Exploiting fungal cell wall components in vaccines. Semin Immunopathol. 2015 Mar; 37(2):199-207. PMID: 25404118.
      View in: PubMed
    15. Chaudhari SS, Moussian B, Specht CA, Arakane Y, Kramer KJ, Beeman RW, Muthukrishnan S. Functional specialization among members of Knickkopf family of proteins in insect cuticle organization. PLoS Genet. 2014 Aug; 10(8):e1004537. PMID: 25144557.
      View in: PubMed
    16. Donlin MJ, Upadhya R, Gerik KJ, Lam W, VanArendonk LG, Specht CA, Sharma NK, Lodge JK. Cross talk between the cell wall integrity and cyclic AMP/protein kinase A pathways in Cryptococcus neoformans. MBio. 2014 Aug 12; 5(4). PMID: 25118241.
      View in: PubMed
    17. Bueter CL, Lee CK, Wang JP, Ostroff GR, Specht CA, Levitz SM. Spectrum and mechanisms of inflammasome activation by chitosan. J Immunol. 2014 Jun 15; 192(12):5943-51. PMID: 24829412.
      View in: PubMed
    18. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Characterization and optimization of the glucan particle-based vaccine platform. Clin Vaccine Immunol. 2013 Oct; 20(10):1585-91. PMID: 23945157.
      View in: PubMed
    19. Chaudhari SS, Arakane Y, Specht CA, Moussian B, Kramer KJ, Muthukrishnan S, Beeman RW. Retroactive maintains cuticle integrity by promoting the trafficking of Knickkopf into the procuticle of Tribolium castaneum. PLoS Genet. 2013; 9(1):e1003268. PMID: 23382702.
      View in: PubMed
    20. Bueter CL, Specht CA, Levitz SM. Innate sensing of chitin and chitosan. PLoS Pathog. 2013 Jan; 9(1):e1003080. PMID: 23326227.
      View in: PubMed
    21. Jasrapuria S, Specht CA, Kramer KJ, Beeman RW, Muthukrishnan S. Gene families of cuticular proteins analogous to peritrophins (CPAPs) in Tribolium castaneum have diverse functions. PLoS One. 2012; 7(11):e49844. PMID: 23185457.
      View in: PubMed
    22. Heustis RJ, Ng HK, Brand KJ, Rogers MC, Le LT, Specht CA, Fuhrman JA. Pharyngeal polysaccharide deacetylases affect development in the nematode C. elegans and deacetylate chitin in vitro. PLoS One. 2012; 7(7):e40426. PMID: 22808160.
      View in: PubMed
    23. Huang H, Ostroff GR, Lee CK, Agarwal S, Ram S, Rice PA, Specht CA, Levitz SM. Relative contributions of dectin-1 and complement to immune responses to particulate ß-glucans. J Immunol. 2012 Jul 1; 189(1):312-7. PMID: 22649195.
      View in: PubMed
    24. Gilbert NM, Baker LG, Specht CA, Lodge JK. A glycosylphosphatidylinositol anchor is required for membrane localization but dispensable for cell wall association of chitin deacetylase 2 in Cryptococcus neoformans. MBio. 2012; 3(1). PMID: 22354955.
      View in: PubMed
    25. Merzendorfer H, Kim HS, Chaudhari SS, Kumari M, Specht CA, Butcher S, Brown SJ, Manak JR, Beeman RW, Kramer KJ, Muthukrishnan S. Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum. Insect Biochem Mol Biol. 2012 Apr; 42(4):264-76. PMID: 22212827.
      View in: PubMed
    26. Chaudhari SS, Arakane Y, Specht CA, Moussian B, Boyle DL, Park Y, Kramer KJ, Beeman RW, Muthukrishnan S. Knickkopf protein protects and organizes chitin in the newly synthesized insect exoskeleton. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17028-33. PMID: 21930896.
      View in: PubMed
    27. Agarwal S, Specht CA, Haibin H, Ostroff GR, Ram S, Rice PA, Levitz SM. Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycans. MBio. 2011; 2(5). PMID: 21878570.
      View in: PubMed
    28. Bueter CL, Lee CK, Rathinam VA, Healy GJ, Taron CH, Specht CA, Levitz SM. Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J Biol Chem. 2011 Oct 14; 286(41):35447-55. PMID: 21862582.
      View in: PubMed
    29. Baker LG, Specht CA, Lodge JK. Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans. Eukaryot Cell. 2011 Sep; 10(9):1264-8. PMID: 21784998.
      View in: PubMed
    30. Ramirez-Ortiz ZG, Lee CK, Wang JP, Boon L, Specht CA, Levitz SM. A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus. Cell Host Microbe. 2011 May 19; 9(5):415-24. PMID: 21575912.
      View in: PubMed
    31. Jesus MD, Nicola AM, Chow SK, Lee IR, Nong S, Specht CA, Levitz SM, Casadevall A. Glucuronoxylomannan, galactoxylomannan, and mannoprotein occupy spatially separate and discrete regions in the capsule of Cryptococcus neoformans. Virulence. 2010 Nov-Dec; 1(6):500-8. PMID: 21178496.
      View in: PubMed
    32. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles. MBio. 2010 Jul 20; 1(3). PMID: 20802824.
      View in: PubMed
    33. Gilbert NM, Donlin MJ, Gerik KJ, Specht CA, Djordjevic JT, Wilson CF, Sorrell TC, Lodge JK. KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. Mol Microbiol. 2010 Apr; 76(2):517-34. PMID: 20384682.
      View in: PubMed
    34. Baker LG, Specht CA, Lodge JK. Chitinases are essential for sexual development but not vegetative growth in Cryptococcus neoformans. Eukaryot Cell. 2009 Nov; 8(11):1692-705. PMID: 19734369.
      View in: PubMed
    35. Huang H, Ostroff GR, Lee CK, Wang JP, Specht CA, Levitz SM. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun. 2009 May; 77(5):1774-81. PMID: 19273561.
      View in: PubMed
    36. Arakane Y, Dixit R, Begum K, Park Y, Specht CA, Merzendorfer H, Kramer KJ, Muthukrishnan S, Beeman RW. Analysis of functions of the chitin deacetylase gene family in Tribolium castaneum. Insect Biochem Mol Biol. 2009 May-Jun; 39(5-6):355-65. PMID: 19268706.
      View in: PubMed
    37. Gerik KJ, Bhimireddy SR, Ryerse JS, Specht CA, Lodge JK. PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans. Eukaryot Cell. 2008 Oct; 7(10):1685-98. PMID: 18689526.
      View in: PubMed
    38. Arakane Y, Specht CA, Kramer KJ, Muthukrishnan S, Beeman RW. Chitin synthases are required for survival, fecundity and egg hatch in the red flour beetle, Tribolium castaneum. Insect Biochem Mol Biol. 2008 Oct; 38(10):959-62. PMID: 18718535.
      View in: PubMed
    39. Ramirez-Ortiz ZG, Specht CA, Wang JP, Lee CK, Bartholomeu DC, Gazzinelli RT, Levitz SM. Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect Immun. 2008 May; 76(5):2123-9. PMID: 18332208.
      View in: PubMed
    40. Dixit R, Arakane Y, Specht CA, Richard C, Kramer KJ, Beeman RW, Muthukrishnan S. Domain organization and phylogenetic analysis of proteins from the chitin deacetylase gene family of Tribolium castaneum and three other species of insects. Insect Biochem Mol Biol. 2008 Apr; 38(4):440-51. PMID: 18342249.
      View in: PubMed
    41. Specht CA, Nong S, Dan JM, Lee CK, Levitz SM. Contribution of glycosylation to T cell responses stimulated by recombinant Cryptococcus neoformans mannoprotein. J Infect Dis. 2007 Sep 1; 196(5):796-800. PMID: 17674324.
      View in: PubMed
    42. Baker LG, Specht CA, Donlin MJ, Lodge JK. Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryot Cell. 2007 May; 6(5):855-67. PMID: 17400891.
      View in: PubMed
    43. Levitz SM, Specht CA. The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins. FEMS Yeast Res. 2006 Jun; 6(4):513-24. PMID: 16696647.
      View in: PubMed
    44. Van Dellen KL, Bulik DA, Specht CA, Robbins PW, Samuelson JC. Heterologous expression of an Entamoeba histolytica chitin synthase in Saccharomyces cerevisiae. Eukaryot Cell. 2006 Jan; 5(1):203-6. PMID: 16400183.
      View in: PubMed
    45. Lam JS, Mansour MK, Specht CA, Levitz SM. A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity. J Immunol. 2005 Dec 1; 175(11):7496-503. PMID: 16301657.
      View in: PubMed
    46. Banks IR, Specht CA, Donlin MJ, Gerik KJ, Levitz SM, Lodge JK. A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell. 2005 Nov; 4(11):1902-12. PMID: 16278457.
      View in: PubMed
    47. Dünkler A, Walther A, Specht CA, Wendland J. Candida albicans CHT3 encodes the functional homolog of the Cts1 chitinase of Saccharomyces cerevisiae. Fungal Genet Biol. 2005 Nov; 42(11):935-47. PMID: 16214381.
      View in: PubMed
    48. Colussi PA, Specht CA, Taron CH. Characterization of a nucleus-encoded chitinase from the yeast Kluyveromyces lactis. Appl Environ Microbiol. 2005 Jun; 71(6):2862-9. PMID: 15932978.
      View in: PubMed
    49. Hogenkamp DG, Arakane Y, Zimoch L, Merzendorfer H, Kramer KJ, Beeman RW, Kanost MR, Specht CA, Muthukrishnan S. Chitin synthase genes in Manduca sexta: characterization of a gut-specific transcript and differential tissue expression of alternately spliced mRNAs during development. Insect Biochem Mol Biol. 2005 Jun; 35(6):529-40. PMID: 15857759.
      View in: PubMed
    50. Lesage G, Shapiro J, Specht CA, Sdicu AM, Ménard P, Hussein S, Tong AH, Boone C, Bussey H. An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae. BMC Genet. 2005 Feb 16; 6:8. PMID: 15715908.
      View in: PubMed
    51. Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D'Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25; 307(5713):1321-4. PMID: 15653466.
      View in: PubMed
    52. Sobering AK, Watanabe R, Romeo MJ, Yan BC, Specht CA, Orlean P, Riezman H, Levin DE. Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER. Cell. 2004 May 28; 117(5):637-48. PMID: 15163411.
      View in: PubMed
    53. Garcerá-Teruel A, Xoconostle-Cázares B, Rosas-Quijano R, Ortiz L, León-Ramírez C, Specht CA, Sentandreu R, Ruiz-Herrera J. Loss of virulence in Ustilago maydis by Umchs6 gene disruption. Res Microbiol. 2004 Mar; 155(2):87-97. PMID: 14990260.
      View in: PubMed
    54. Arakane Y, Hogenkamp DG, Zhu YC, Kramer KJ, Specht CA, Beeman RW, Kanost MR, Muthukrishnan S. Characterization of two chitin synthase genes of the red flour beetle, Tribolium castaneum, and alternate exon usage in one of the genes during development. Insect Biochem Mol Biol. 2004 Mar; 34(3):291-304. PMID: 14871625.
      View in: PubMed
    55. Bulik DA, Olczak M, Lucero HA, Osmond BC, Robbins PW, Specht CA. Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress. Eukaryot Cell. 2003 Oct; 2(5):886-900. PMID: 14555471.
      View in: PubMed
    56. Zhu YC, Specht CA, Dittmer NT, Muthukrishnan S, Kanost MR, Kramer KJ. Sequence of a cDNA and expression of the gene encoding a putative epidermal chitin synthase of Manduca sexta. Insect Biochem Mol Biol. 2002 Nov; 32(11):1497-506. PMID: 12530217.
      View in: PubMed
    57. Huang C, Nong SH, Mansour MK, Specht CA, Levitz SM. Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-Cell responses. Infect Immun. 2002 Oct; 70(10):5485-93. PMID: 12228274.
      View in: PubMed
    58. Specht CA. Isolation of the B alpha and B beta mating-type loci of Schizophyllum commune. Curr Genet. 1995 Sep; 28(4):374-9. PMID: 8590484.
      View in: PubMed
    59. Ullrich RC, Specht CA, Stankis MM, Yang H, Giasson L, Novotny CP. Molecular biology of mating-type determination in Schizophyllum commune. Genet Eng (N Y). 1991; 13:279-306. PMID: 1367417.
      View in: PubMed
    60. Munoz-Rivas A, Specht CA, Drummond BJ, Froeliger E, Novotny CP, Ullrich RC. Transformation of the basidiomycete, Schizophyllum commune. Mol Gen Genet. 1986 Oct; 205(1):103-6. PMID: 3467155.
      View in: PubMed
    61. Price M, Specht C, Boudreau RE, Shaw DE, Weller DL. Preliminary characterization of ribosomes of Entamoeba invadens. Mol Biochem Parasitol. 1983 Jun; 8(2):137-43. PMID: 6348536.
      View in: PubMed
    62. Hanlon DP, Specht C, Ferm VH. The chemical status of cadmium ion in the placenta. Environ Res. 1982 Feb; 27(1):89-94. PMID: 7067683.
      View in: PubMed
    63. Specht CA, DiRusso CC, Novotny CP, Ullrich RC. A method for extracting high-molecular-weight deoxyribonucleic acid from fungi. Anal Biochem. 1982 Jan 1; 119(1):158-63. PMID: 7041693.
      View in: PubMed
    64. Weller DL, Richman A, Specht C. Ribonuclease of Entamoeba invadens. Mol Biochem Parasitol. 1981 Nov; 4(1-2):1-7. PMID: 6172708.
      View in: PubMed
    65. Ullrich RC, Kohorn BD, Specht CA. Absence of short-period repetitive-sequence interspersion in the basidiomycete Schizophyllum commune. Chromosoma. 1980; 81(3):371-8. PMID: 6256137.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Specht's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _