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Ellen M Gravallese MD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressHale Building for Transformative Medicine
60 Fenwood Road, Room 6002U
Boston MA 02115
Phone617-525-1000
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABBiochemical Sciences
    Columbia University College of Physicians and Surgeons, New York, NY, United StatesMD

    Collapse Overview 
    Collapse overview

    Research in my laboratory is devoted to the study of the pathogenesis of rheumatoid arthritis (RA), with particular interest in the fundamental mechanisms of bone and cartilage destruction. Through studies of human tissues using pathologic and molecular techniques, murine models of disease and in-vitro assays, this research has contributed to the development of new clinical interventions. Research areas can be summarized into four major categories: 1) Identification of cell types and pathways that drive osteoclastogenesis.  2) Identification of the effects of synovial inflammation on inhibiting osteoblast function and bone formation, thus inhibiting bone repair.    3) Identification of the role of innate immune pathways, in particular the cytosolic DNA sensor and endosomal TLR pathways, in the regulation of specific manifestations of autoimmunity.  4) Role of microRNAs in the regulation of autoimmune diseases and bone.


    Initial work in my laboratory identified the cells responsible for bone erosion in RA by demonstrating that osteoclasts are the essential cells in articular bone loss in RA. We further identified synovial fibroblasts and activated CD4+ T lymphocytes in RA synovium as sources of RANKL, a cytokine required for osteoclast differentiation and activation. The essential role of RANKL and of osteoclasts in bone erosion in RA was demonstrated in my laboratory through the generation of arthritis (by serum transfer) in RANKL-deficient mice. We have also demonstrated the impact of inflammation in the bone microenvironment on osteoblasts, showing that osteoblast maturation and function is compromised at sites of inflammation in bone, inhibiting bone repair. We showed that inhibitors of the Wnt signaling pathway, including DKK family members, contribute to the inhibition of osteoblast function and bone formation at sites of erosion. We have initiated a clinical trial in RA to assess the efficacy of intermittent PTH, an anabolic agent, in promoting the healing of articular erosions in RA.


    Finally, in a new direction for my laboratory, we are working to understand the contribution of innate and adaptive immune mechanisms to the onset, progression, persistence and regulation of systemic autoimmune diseases, with particular attention to RA and systemic lupus erythematosus. The past decade has seen a paradigm shift in our understanding of the mechanisms underlying autoimmune and inflammatory diseases.  We have come to realize that aberrant regulation of innate immune system components has a major impact on disease etiology. Our work has led to insights into specific pathways regulating distinct autoimmune manifestations, providing new targets for intervention in these diseases.



    Collapse Rotation Projects


    Several projects are open to rotating students, including projects in the area of innate immunity and DNase II deficient mice, effects of inflammation on bone in rheumatic diseases, and regulation of arthritis and bone destruction by microRNAs.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM. Reply to Morning Stiffness and Neutrophil Circadian Disarming. Arthritis Rheumatol. 2020 Sep 06. PMID: 32892514.
      View in: PubMed
    2. Mikuls TR, Johnson SR, Fraenkel L, Arasaratnam RJ, Baden LR, Bermas BL, Chatham W, Cohen S, Costenbader K, Gravallese EM, Kalil AC, Weinblatt ME, Winthrop K, Mudano AS, Turner A, Saag KG. American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID-19 Pandemic: Version 2. Arthritis Rheumatol. 2020 Jul 30. PMID: 32734689.
      View in: PubMed
    3. Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM. Reply to Determinants of Early Morning Stiffness in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Jul 30. PMID: 32729675.
      View in: PubMed
    4. Gravallese EM, Robinson WH. PRIME Time in Rheumatoid Arthritis. N Engl J Med. 2020 07 16; 383(3):278-279. PMID: 32668119.
      View in: PubMed
    5. D'Silva KM, Serling-Boyd N, Wallwork R, Hsu T, Fu X, Gravallese EM, Choi HK, Sparks JA, Wallace ZS. Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US 'hot spot'. Ann Rheum Dis. 2020 May 26. PMID: 32457048.
      View in: PubMed
    6. Gravallese EM. Introducing the New Editor of Arthritis & Rheumatology, Daniel H. Solomon, MD, MPH. Arthritis Rheumatol. 2020 May 05. PMID: 32368870.
      View in: PubMed
    7. Mikuls TR, Johnson SR, Fraenkel L, Arasaratnam RJ, Baden LR, Bermas BL, Chatham W, Cohen S, Costenbader K, Gravallese EM, Kalil AC, Weinblatt ME, Winthrop K, Mudano AS, Turner A, Saag KG. American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVID-19 Pandemic. Arthritis Rheumatol. 2020 Apr 29. PMID: 32349183.
      View in: PubMed
    8. Yang YS, Xie J, Chaugule S, Wang D, Kim JM, Kim J, Tai PWL, Seo SK, Gravallese E, Gao G, Shim JH. Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:922-935. PMID: 32405514.
      View in: PubMed
    9. Marshak-Rothstein A, Manning CA, Baum R, Pawaria S, Gravallese EM. Interplay of Cyclic GMP-AMP Synthase/Stimulator of IFN Genes and Toll-Like Receptor Nucleic Acid Sensing Pathways in Autoinflammation and Abnormal Bone Formation due to DNaseII-Deficiency. Viral Immunol. 2020 Apr; 33(3):246-249. PMID: 32286184.
      View in: PubMed
    10. Chen S, van Tok MN, Knaup VL, Kraal L, Pots D, Bartels L, Gravallese EM, Taurog JD, van de Sande M, van Duivenvoorde LM, Baeten DL. mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo. Front Immunol. 2019; 10:2344. PMID: 32194539.
      View in: PubMed
    11. Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils. Arthritis Rheumatol. 2019 Oct 15. PMID: 31612614.
      View in: PubMed
    12. Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. The Role of IFN?-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency. Arthritis Rheumatol. 2019 Aug 28. PMID: 31464028.
      View in: PubMed
    13. Yang YS, Xie J, Wang D, Kim JM, Tai PWL, Gravallese E, Gao G, Shim JH. Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis. Nat Commun. 2019 Jul 04; 10(1):2958. PMID: 31273195.
      View in: PubMed
    14. Henchie TF, Gravallese EM, Bredbenner TL, Troy KL. An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study. Comput Methods Biomech Biomed Engin. 2019 May 08; 1-11. PMID: 31064209.
      View in: PubMed
    15. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 May 06. PMID: 31061532.
      View in: PubMed
    16. Orange DE, Agius P, DiCarlo EF, Mirza S, Pannellini T, Szymonifka J, Jiang CS, Figgie MP, Frank MO, Robinson WH, Donlin LT, Rozo C, Gravallese EM, Bykerk VP, Goodman SM. Histologic and transcriptional evidence of subclinical synovial inflammation in rheumatoid arthritis patients in clinical remission. Arthritis Rheumatol. 2019 Mar 05. PMID: 30835943.
      View in: PubMed
    17. Gregersen PK, Gravallese EM. Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis. N Engl J Med. 2018 Oct 20. PMID: 30345908.
      View in: PubMed
    18. Gravallese EM, Schett G. Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis. Nat Rev Rheumatol. 2018 Sep 28. PMID: 30266977.
      View in: PubMed
    19. Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Res Ther. 2018 Jul 11; 20(1):139. PMID: 29996944.
      View in: PubMed
    20. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Author Correction: Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 May 11; 9(1):1954. PMID: 29752435.
      View in: PubMed
    21. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 Apr 03; 9(1):1275. PMID: 29615615.
      View in: PubMed
    22. Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis Rheumatol. 2018 May; 70(5):690-701. PMID: 29468833.
      View in: PubMed
    23. Bridges SL, White DW, Worthing AB, Gravallese EM, O'Dell JR, Nola K, Kay J, Cohen SB. The Science Behind Biosimilars: Entering a New Era of Biologic Therapy. Arthritis Rheumatol. 2018 03; 70(3):334-344. PMID: 29411547.
      View in: PubMed
    24. Shim JH, Stavre Z, Gravallese EM. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcif Tissue Int. 2017 Dec 04. PMID: 29204672.
      View in: PubMed
    25. Gravallese EM, Kay J, Duryea J, Solomon DH. Reply. Arthritis Rheumatol. 2017 Nov 28. PMID: 29193854.
      View in: PubMed
    26. Solomon DH, Kay J, Duryea J, Lu B, Bolster MB, Yood RA, Han R, Ball S, Coleman C, Lo E, Wohlfahrt A, Sury M, Yin M, Yu Z, Zak A, Gravallese EM. Effects of Teriparatide on Joint Erosions in Rheumatoid Arthritis: A Randomized Controlled Trial. Arthritis Rheumatol. 2017 Sep; 69(9):1741-1750. PMID: 28544807.
      View in: PubMed
    27. Gravallese EM. Bone Wasn't Built in a Day: Destruction and Formation of Bone in the Rheumatic Diseases. Trans Am Clin Climatol Assoc. 2017; 128:24-43. PMID: 28790485.
      View in: PubMed
    28. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 Dec; 68(12):2889-2900. PMID: 27563728.
      View in: PubMed
    29. Stavre Z, Upchurch K, Kay J, Gravallese EM. Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis. Curr Rheumatol Rep. 2016 Dec; 18(12):72. PMID: 27812955.
      View in: PubMed
    30. Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM. STING regulates abnormal bone formation induced by deficiency of DNase II. Arthritis Rheumatol. 2016 Oct 14. PMID: 27740718.
      View in: PubMed
    31. Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis. J Bone Miner Res. 2016 Sep 27. PMID: 27676131.
      View in: PubMed
    32. Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 Jan; 101(1):121-126. PMID: 27531928.
      View in: PubMed
    33. Baum R, Gravallese EM. Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts. Clin Rev Allergy Immunol. 2016 Aug; 51(1):1-15. PMID: 26411424.
      View in: PubMed
    34. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 Aug; 17(8):922-9. PMID: 27270400.
      View in: PubMed
    35. Shaw AT, Maeda Y, Gravallese EM. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016 May 10; 18(1):104. PMID: 27165410.
      View in: PubMed
    36. Duryea J, Russell R, Gravallese EM, Kay J, Han R, Lu B, Solomon DH. Brief Report: Development and Validation of a Semiautomated Method to Measure Erosion Volume in Inflammatory Arthritis by Computed Tomography Scanning. Arthritis Rheumatol. 2016 Feb; 68(2):332-6. PMID: 26473501.
      View in: PubMed
    37. Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 1; 196(3):1348-54. PMID: 26729810.
      View in: PubMed
    38. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57. PMID: 26315890.
      View in: PubMed
    39. Shaw AT, Gravallese EM. Mediators of inflammation and bone remodeling in rheumatic disease. Semin Cell Dev Biol. 2016 Jan; 49:2-10. PMID: 26481971.
      View in: PubMed
    40. Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
      View in: PubMed
    41. Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015 Feb 1; 194(3):873-7. PMID: 25548216.
      View in: PubMed
    42. Kim SJ, Chen Z, Chamberlain ND, Essani AB, Volin MV, Amin MA, Volkov S, Gravallese EM, Arami S, Swedler W, Lane NE, Mehta A, Sweiss N, Shahrara S. Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis. J Immunol. 2014 Oct 15; 193(8):3902-13. PMID: 25200955.
      View in: PubMed
    43. Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1ß production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072.
      View in: PubMed
    44. Baum R, Gravallese EM. Impact of inflammation on the osteoblast in rheumatic diseases. Curr Osteoporos Rep. 2014 Mar; 12(1):9-16. PMID: 24363057.
      View in: PubMed
    45. Kay J, Morgacheva O, Messing SP, Kremer JM, Greenberg JD, Reed GW, Gravallese EM, Furst DE. Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year. Arthritis Res Ther. 2014; 16(1):R40. PMID: 24485007.
      View in: PubMed
    46. Dusad A, Duryee MJ, Shaw AT, Klassen LW, Anderson DR, Wang D, Ren K, Gravallese EM, O'Dell JR, Mikuls TR, Thiele GM. Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant. Immunol Res. 2014 Jan; 58(1):51-60. PMID: 24371010.
      View in: PubMed
    47. Kay J, Gravallese EM. Rheumatoid arthritis: erosion defined: back to basics. Nat Rev Rheumatol. 2013 Jun; 9(6):323-4. PMID: 23609778.
      View in: PubMed
    48. Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov; 8(11):656-64. PMID: 23007741.
      View in: PubMed
    49. Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum. 2012 May; 64(5):1540-50. PMID: 22139865.
      View in: PubMed
    50. Gravallese EM, Walsh NC. Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation. Nat Rev Rheumatol. 2011 Sep 20; 7(11):626-8. PMID: 21931342.
      View in: PubMed
    51. Salomon-Escoto KI, Gravallese EM, Kay J. Assessment of control of rheumatoid arthritis disease activity. Best Pract Res Clin Rheumatol. 2011 Aug; 25(4):497-507. PMID: 22137920.
      View in: PubMed
    52. Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010 May; 36(2):385-404. PMID: 20510240.
      View in: PubMed
    53. Walsh NC, Gravallese EM. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev. 2010 Jan; 233(1):301-12. PMID: 20193007.
      View in: PubMed
    54. Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH. Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA. Rheumatology (Oxford). 2010 Mar; 49(3):513-9. PMID: 20026562.
      View in: PubMed
    55. Walsh NC, Reinwald S, Manning CA, Condon KW, Iwata K, Burr DB, Gravallese EM. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res. 2009 Sep; 24(9):1572-85. PMID: 19338457.
      View in: PubMed
    56. Colbert RA, Deodhar AA, Fox D, Gravallese EM, Khan MA, McGonagle D, Reveille JD, Schett G, Weisman M, Clegg DO. Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). J Rheumatol. 2009 Jul; 36(7):1527-31. PMID: 19567633.
      View in: PubMed
    57. Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt ME, Gravallese EM. The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 2009 Jun; 60(6):1624-31. PMID: 19479876.
      View in: PubMed
    58. Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR. The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther. 2006; 8(3):R70. PMID: 16613614.
      View in: PubMed
    59. Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51. PMID: 16313352.
      View in: PubMed
    60. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005 Nov 18; 280(46):38544-55. PMID: 16144844.
      View in: PubMed
    61. Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr; 272(7):1676-87. PMID: 15794755.
      View in: PubMed
    62. Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94. PMID: 15334485.
      View in: PubMed
    63. Goldring SR, Gravallese EM. Bisphosphonates: environmental protection for the joint? Arthritis Rheum. 2004 Jul; 50(7):2044-7. PMID: 15248201.
      View in: PubMed
    64. Walsh NC, Gravallese EM. Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004 Jul; 16(4):419-27. PMID: 15201606.
      View in: PubMed
    65. Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26; 279(13):12794-803. PMID: 14715662.
      View in: PubMed
    66. Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003 Jul; 112(2):147-9. PMID: 12865402.
      View in: PubMed
    67. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum. 2003 May; 48(5):1249-60. PMID: 12746898.
      View in: PubMed
    68. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology Journals. Arthritis Rheum. 2003 Apr 15; 49(2):149-50. PMID: 12687503.
      View in: PubMed
    69. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology journals. Arthritis Rheum. 2003 Apr; 48(4):873-5. PMID: 12687527.
      View in: PubMed
    70. Lubberts E, Oppers-Walgreen B, Pettit AR, Van Den Bersselaar L, Joosten LA, Goldring SR, Gravallese EM, Van Den Berg WB. Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3055-64. PMID: 12428250.
      View in: PubMed
    71. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med. 2002 Jul 1; 196(1):77-85. PMID: 12093872.
      View in: PubMed
    72. Goldring SR, Gravallese EM. Pathogenesis of bone lesions in rheumatoid arthritis. Curr Rheumatol Rep. 2002 Jun; 4(3):226-31. PMID: 12010607.
      View in: PubMed
    73. Husni ME, Maier AL, Mease PJ, Overman SS, Fraser P, Gravallese EM, Weinblatt ME. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum. 2002 May; 46(5):1171-6. PMID: 12115220.
      View in: PubMed
    74. Hou WS, Li W, Keyszer G, Weber E, Levy R, Klein MJ, Gravallese EM, Goldring SR, Brömme D. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002 Mar; 46(3):663-74. PMID: 11920402.
      View in: PubMed
    75. Miszke A. [Our observations on hearing, equilibrium and vision disorders as well as factors predisposing to these disorders following streptomycin treatment]. Pol Tyg Lek. 1973 Oct 15; 28(42):1648-50. PMID: 4761455.
      View in: PubMed
    76. Nief L, Haustete P. [Antibiotic therapy of alveolar wounds]. Inf Dent. 1968 Jan 11; 50(2):139-45. PMID: 4299698.
      View in: PubMed
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