Loading...
Header Logo
Keywords
Last Name
Institution

John F Keaney MD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-334-2266
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABBiochemistry/Molecular Biology
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Overview 
    Collapse overview

    Education:

    • 1983 A.B. Harvard College
    • 1987 M.D. Yale University School of Medicine

    Postdoctoral Training

    Internship and Residency:
    • 1987-1988 Intern in Medicine, Brigham & Women's Hospital, Boston, MA
    • 1988-1989 Junior Assistant Resident, Brigham & Women's Hospital, Boston, MA
    Fellowship:
    • 1989-1990 Clinical Fellow, Cardiology, Brigham & Women's Hospital, Boston, MA
    • 1990-1992 Clinical and Research Fellow in Cardiology, Brigham & Women's Hospital, Boston, MA

    Licensure and Certification

    • 1988 Diplomate, National Board of Medical Examiners
    • 1989 Massachusetts Medical License, No. 70338
    • 1991 Diplomate, American Board of Internal Medicine
    • 1993 Diplomate, Subspecialty in Cardiovascular Diseases
    • 1995 Certification: Palmaz-Schatz stent implantation
    • 1999 ABIM Certification in Interventional Cardiology
    • 2001 ABIM Recertification in Internal Medicine and Cardiology

    Memberships in Professional Societies

    • 1984- Massachusetts Medical Society
    • 1984- Norfolk County Medical Society
    • 1992- American Association for the Advancement of Science
    • 1992- American Federation for Clinical Research
    • 1992- American College of Physicians
    • 1996- Fellow, American College of Cardiology
    • 1996- American Physiological Society
    • 1996- Fellow, American Heart Association, Council on Arteriosclerosis.
    • 1997- Fellow, American Heart Association, Council on Circulation
    • 1998- Society for Free Radical Biology in Medicine
    • 2001- Fellow, American Heart Association
    • 2001- American Society of Biochemistry and Molecular Biology
    • 2006- American Society of Clinical Investigation
    • 2007- Association of University Cardiologists

    John F Keaney,  JrJohn F. Keaney, Jr, MD

    Division Chief, Cardiovascular Medicine
    Department of Medicine
    University of Massachusetts Medical School

    Research Grants

    • 1992-1994 F32HL08635, National Research Service Award, NIH
    • 1994-1995 Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
    • 1994-1996 Grant-in-Aid, American Heart Association, Mass. Affiliate
    • 1995-2000 K08HL03195, Clinical Investigator Development Award, NIH
    • 1995-1998 Research Grant, Council for Tobacco Research, USA #4073
    • 1996-1999 Grant-in-Aid, American Heart Association, National Center
    • 1996-2001 P01HL55854, Project Leader, Mechanism(s) of Excess LDL Oxidation in Diabetes, NIH
    • 1997-2000 R01HL59634, Vitamin C, GSH, and Endothelium-Derived NO, NIH
    • 1997-2001 R01HL58936, Homocysteine, Oxidative Stress, and Nitric Oxide, NIH
    • 2000-2004 R01DK55656, Cellular Vitamin E Status and Integrin Function, NIH
    • 2000-2004 Established Investigator Award, American Heart Association
    • 2000-2005 P01HL60886, Project Leader, Vitamin C, GSH, and EDNO, NIH
    • 2001-2006 T32HL07224-30, Basic Science Cardiovascular Training Program
    • 2002-2005 Oxidative Stress, AMP kinase, and EDNO (Project 2), NIH/NHLBI and JDRF Center for Study of Diabetic Complications
    • 2003-2008 R01HL61766, HOCl-Mediated Impairment of Endothelial Function, NIH
    • 2005-2010 R01AG027081, Nox Isoforms in the Control of Endothelial Cell Phenotype
    • 2005-2010 P01HL81587, Endothelial Redox State and Phenotype in Health and Disease
    • 2009-2012 RO1HL09122, Mitochondrial Biogenesis and Endothelial Cell Phenotype, NIH
    • 2010-2014 RO1HL098407, Nox4 and Vascular Homeostasis

    Awards and Honors

    • 1983Magna Cum Laude, Harvard College
    • 1987Cum Laude, Yale University School of Medicine
    • 1987Alpha Omega Alpha
    • 1987Norma Bailey Berniker Prize, Yale University School of Medicine
    • 1987Merck Merit Award, Yale University School of Medicine
    • 1992Merck/ACC Research Fellow Award, American College of Cardiology
    • 1992National Research Service Award, National Institutes of Health.
    • 1992Ignacio Chavez Young Investigator Award, XIV InterAmerican Congress of Cardiology, Orlando, FL
    • 1994Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
    • 1995Clinical Investigator Development Award, National Institutes of Health
    • 1997Ad Hoc Member, Experimental Cardiovascular Sciences Study Section, NIH
    • 1998Ad Hoc Member, Nutrition Study Section, NIH
    • 2000Established Investigator Award, American Heart Association
    • 2001Co-Chair, Cardiorenal Grant Review Panel, AHA New England Affiliate
    • 2002Chair, Cardiorenal Review Panel, AHA Northeast Region
    • 2003Young Investigator Award Review Panel, The Medical Foundation, Boston, MA
    • 2004Ad Hoc Member, Atherosclerosis and Inflammation Study Section, NIH
    • 2004-2007 Charter Member, Vascular Cell and Molecular Biology Study Section, NIH
    • 2004-Associate Editor, Circulation
    • 2005Outstanding Medical Student Mentor, Boston University School of Medicine
    • 2006American Society for Clinical Investigation
    • 2006-Charter Member and Chair, Molecular Signaling Review Panel, AHA National Center
    • 2007-Association of University Cardiologists
    • 2012-Deputy Editor, Journal of the American Heart Association
    • 2012-Chair, Research Committee, AHA Founder's Affiliate



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kuntic M, Oelze M, Steven S, Kröller-Schön S, Stamm P, Kalinovic S, Frenis K, Vujacic-Mirski K, Bayo Jimenez MT, Kvandova M, Filippou K, Al Zuabi A, Brückl V, Hahad O, Daub S, Varveri F, Gori T, Huesmann R, Hoffmann T, Schmidt FP, Keaney JF, Daiber A, Münzel T. Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2). Eur Heart J. 2019 Nov 13. PMID: 31715629.
      View in: PubMed
    2. Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nat Commun. 2019 Sep 17; 10(1):4223. PMID: 31530804.
      View in: PubMed
    3. Craige S, Chen K, Blanton R, Keaney J, Kant S. JNK and cardiometabolic dysfunction. Biosci Rep. 2019 Jul 03. PMID: 31270248.
      View in: PubMed
    4. Tran KV, Tanriverdi K, Aurigemma GP, Lessard D, Sardana M, Parker M, Shaikh A, Gottbrecht M, Milstone Z, Tanriverdi S, Vitseva O, Keaney JF, Kiefe CI, McManus DD, Freedman JE. Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome. J Clin Transl Res. 2019 Sep 08; 5(1):33-43. PMID: 31579840.
      View in: PubMed
    5. Min SY, Learnard H, Kant S, Gealikman O, Rojas-Rodriguez R, DeSouza T, Desai A, Keaney JF, Corvera S, Craige SM. Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue. Int J Mol Sci. 2019 Apr 25; 20(8). PMID: 31027261.
      View in: PubMed
    6. Münzel T, Hahad O, Gori T, Hollmann S, Arnold N, Prochaska JH, Schulz A, Beutel M, Pfeiffer N, Schmidtmann I, Lackner KJ, Keaney JF, Wild PS. Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study. Clin Res Cardiol. 2019 Apr 05. PMID: 30953178.
      View in: PubMed
    7. Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E. Endothelial a1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction. Basic Res Cardiol. 2019 Jan 14; 114(2):8. PMID: 30643968.
      View in: PubMed
    8. Keaney JF, Rosen CJ. VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease. N Engl J Med. 2018 Nov 10. PMID: 30415594.
      View in: PubMed
    9. Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF, Vasan RS, Benjamin EJ, Mittleman MA. Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study. Environ Res. 2018 Oct 28; 171:36-43. PMID: 30654247.
      View in: PubMed
    10. Hendrix RJ, Bello RA, Flahive JM, Kakouros N, Aurigemma GP, Keaney JF, Hoffman W, Vassileva CM. Mitral valve repair vs replacement in elderly with degenerative disease: Analysis of the STS Adult Cardiac Surgery Database. Ann Thorac Surg. 2018 Oct 26. PMID: 30612990.
      View in: PubMed
    11. Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF, Münzel T, Wenzel P, Schulz E. a1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction. Cardiovasc Res. 2018 Jul 04. PMID: 29982418.
      View in: PubMed
    12. Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G. First experience with zero-fluoroscopic ablation for supraventricular tachycardias using a novel impedance and magnetic-field-based mapping system. Clin Res Cardiol. 2018 Jul; 107(7):578-585. PMID: 29476203.
      View in: PubMed
    13. Conlon R, Tanner R, David S, Szeplaki G, Galvin J, Keaney J, Keelan E, Boles U. Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia. Cardiol Res. 2017 Dec; 8(6):280-285. PMID: 29317970.
      View in: PubMed
    14. Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G. Automated ultra-high-density mapping of peri-sinus node premature atrial contractions. Clin Res Cardiol. 2018 Apr; 107(4):368-370. PMID: 29222593.
      View in: PubMed
    15. Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF, Trivedi CM. Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Oct 16. PMID: 29035278.
      View in: PubMed
    16. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF, Zile MR, Aurigemma GP. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 2017; 4:49. PMID: 28824923.
      View in: PubMed
    17. Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF, Vasan RS, Benjamin EJ, Mittleman MA. Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1793-1800. PMID: 28751572.
      View in: PubMed
    18. Zachariah JP, Quiroz R, Nelson KP, Teng Z, Keaney JF, Sullivan LM, Vasan RS. Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study. J Am Heart Assoc. 2017 Jul 16; 6(7). PMID: 28713076.
      View in: PubMed
    19. Zachariah JP, Quiroz R, Enserro D, Andersson C, Keaney JF, Sullivan LM, Vasan RS. Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring. J Am Heart Assoc. 2017 Jul 16; 6(7). PMID: 28713075.
      View in: PubMed
    20. Keaney JF. CHIP-ping Away at Atherosclerosis. N Engl J Med. 2017 Jun 21. PMID: 28636833.
      View in: PubMed
    21. Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF, Cooper MP. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017 May 17; 7(1):2013. PMID: 28515438.
      View in: PubMed
    22. Szeplaki G, Keaney J, Keelan E, Valentine J, Galvin J. Isolation of the superior vena cava to block unidirectional exit conduction from the right-sided pulmonary veins during atrial fibrillation ablation. J Interv Card Electrophysiol. 2017 Apr 08. PMID: 28391548.
      View in: PubMed
    23. Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF. PGC-1a dictates endothelial function through regulation of eNOS expression. Sci Rep. 2016 Dec 02; 6:38210. PMID: 27910955.
      View in: PubMed
    24. Sullivan LM, Weinberg J, Keaney JF. Common Statistical Pitfalls in Basic Science Research. J Am Heart Assoc. 2016 Sep 29; 5(10). PMID: 27688237.
      View in: PubMed
    25. Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 Aug 09; 5. PMID: 27504807.
      View in: PubMed
    26. Lee JJ, Britton KA, Pedley A, Massaro JM, Speliotes EK, Murabito JM, Hoffmann U, Ingram C, Keaney JF, Vasan RS, Fox CS. Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation. J Am Heart Assoc. 2016 May; 5(5). PMID: 27146446.
      View in: PubMed
    27. Li W, Wilker EH, Dorans KS, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Keaney JF, Lin H, Vasan RS, Benjamin EJ, Mittleman MA. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study. J Am Heart Assoc. 2016 May; 5(5). PMID: 27126478.
      View in: PubMed
    28. Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF, Fogarty KE, ZhuGe R, Zhu MS. The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun. 2016 Apr 22; 7:11358. PMID: 27101932.
      View in: PubMed
    29. Keaney JF, Solomon CG. Postmenopausal Hormone Therapy and Atherosclerosis--Time Is of the Essence. N Engl J Med. 2016 Mar 31; 374(13):1279-80. PMID: 27028919.
      View in: PubMed
    30. Li C, Reif MM, Craige SM, Kant S, Keaney JF. Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016 May 1; 55-56:45-53. PMID: 26989010.
      View in: PubMed
    31. Lee JJ, Pedley A, Hoffmann U, Massaro JM, Keaney JF, Vasan RS, Fox CS. Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study. J Am Heart Assoc. 2016 Feb 29; 5(3):e002545. PMID: 26927600.
      View in: PubMed
    32. Khurshid S, Keaney J, Ellinor PT, Lubitz SA. A Simple and Portable Algorithm for Identifying Atrial Fibrillation in the Electronic Medical Record. Am J Cardiol. 2016 Jan 15; 117(2):221-5. PMID: 26684516.
      View in: PubMed
    33. Phillips RA, Cyr J, Keaney JF, Messina LM, Meyer TE, Tam SK, Korenda K, Darrigo M, Kumar P, Challapalli S. Creating and Maintaining a Successful Service Line in an Academic Medical Center at the Dawn of Value-Based Care: Lessons Learned From the Heart and Vascular Service Line at UMass Memorial Health Care. Acad Med. 2015 Oct; 90(10):1340-6. PMID: 26222322.
      View in: PubMed
    34. Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron. 2015 Sep 23; 87(6):1215-33. PMID: 26402605.
      View in: PubMed
    35. Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF. Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med. 2015 Dec; 89:1-7. PMID: 26169727.
      View in: PubMed
    36. Münzel T, Gori T, Keaney JF, Maack C, Daiber A. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur Heart J. 2015 Oct 7; 36(38):2555-64. PMID: 26142467.
      View in: PubMed
    37. Jarcho JA, Keaney JF. Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT. N Engl J Med. 2015 Jun 18; 372(25):2448-50. PMID: 26039520.
      View in: PubMed
    38. Craige SM, Kant S, Keaney JF. Reactive oxygen species in endothelial function - from disease to adaptation - . Circ J. 2015; 79(6):1145-55. PMID: 25986771.
      View in: PubMed
    39. Keaney JF. Balancing the risks and benefits of dual platelet inhibition. N Engl J Med. 2015 May 7; 372(19):1854-6. PMID: 25773507.
      View in: PubMed
    40. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. Circulation. 2015 Jan 27; 131(4):432-3. PMID: 25623127.
      View in: PubMed
    41. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. J Am Heart Assoc. 2015 Jan 26; 4(1):e001778. PMID: 25628411.
      View in: PubMed
    42. Murdoch JD, Gupta AR, Sanders SJ, Walker MF, Keaney J, Fernandez TV, Murtha MT, Anyanwu S, Ober GT, Raubeson MJ, DiLullo NM, Villa N, Waqar Z, Sullivan C, Gonzalez L, Willsey AJ, Choe SY, Neale BM, Daly MJ, State MW. No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins. PLoS Genet. 2015 Jan; 11(1):e1004852. PMID: 25621974.
      View in: PubMed
    43. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF, Donahue JK, Benjamin EJ, Freedman JE. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015 Jan; 12(1):3-10. PMID: 25257092.
      View in: PubMed
    44. Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Rep. 2014 Oct 9; 9(1):16-23. PMID: 25284784.
      View in: PubMed
    45. Keaney JF, Curfman GD, Jarcho JA. The new cholesterol treatment guidelines. N Engl J Med. 2014 May 15; 370(20):1957. PMID: 24827049.
      View in: PubMed
    46. Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O'Donnell CJ, Wolf PA, O'Connor GT, Keaney JF, Vasan RS. Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes. Eur Heart J. 2014 Nov 7; 35(42):2980-7. PMID: 24574370.
      View in: PubMed
    47. Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF, Cooper MP. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest. 2014 Feb; 124(2):768-84. PMID: 24430182.
      View in: PubMed
    48. Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP. Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card Fail. 2014 Jan; 20(1):31-7. PMID: 24333348.
      View in: PubMed
    49. Keaney JF, Curfman GD, Jarcho JA. A pragmatic view of the new cholesterol treatment guidelines. N Engl J Med. 2014 Jan 16; 370(3):275-8. PMID: 24283199.
      View in: PubMed
    50. Hong SN, Gona P, Fontes JD, Oyama N, Chan RH, Kenchaiah S, Tsao CW, Yeon SB, Schnabel RB, Keaney JF, O'Donnell CJ, Benjamin EJ, Manning WJ. Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. J Am Heart Assoc. 2013 Nov 15; 2(6):e000307. PMID: 24242683.
      View in: PubMed
    51. Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD. Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction. Fam Med Med Sci Res. 2013 Oct 1; 2(2):108. PMID: 24432306.
      View in: PubMed
    52. Keaney JF. P2Y12 inhibition in patients with NSTEMI--can later be better? N Engl J Med. 2013 Sep 12; 369(11):1056-7. PMID: 23991623.
      View in: PubMed
    53. McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73. PMID: 23968978.
      View in: PubMed
    54. Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res. 2013 Sep 13; 113(7):891-901. PMID: 23819990.
      View in: PubMed
    55. Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Murabito JM, Vasan RS, Benjamin EJ. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1728-33. PMID: 23640499.
      View in: PubMed
    56. Chami HA, Fontes JD, Vasan RS, Keaney JF, O'Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep. 2013 May 01; 36(5):763-768C. PMID: 23633759.
      View in: PubMed
    57. Fontes JD, Yamamoto JF, Larson MG, Wang N, Dallmeier D, Rienstra M, Schnabel RB, Vasan RS, Keaney JF, Benjamin EJ. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study. Atherosclerosis. 2013 May; 228(1):217-23. PMID: 23489346.
      View in: PubMed
    58. Chen K, Keaney JF. Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease. Curr Atheroscler Rep. 2012 Oct; 14(5):476-83. PMID: 22956414.
      View in: PubMed
    59. Kaess BM, Enserro DM, McManus DD, Xanthakis V, Chen MH, Sullivan LM, Ingram C, O'Donnell CJ, Keaney JF, Vasan RS, Glazer NL. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1943-7. PMID: 22855337.
      View in: PubMed
    60. Dallmeier D, Larson MG, Vasan RS, Keaney JF, Fontes JD, Meigs JB, Fox CS, Benjamin EJ. Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study. Diabetol Metab Syndr. 2012 Jun 20; 4(1):28. PMID: 22716219.
      View in: PubMed
    61. Sugamura K, Keaney JF. Nicotine: linking smoking to abdominal aneurysms. Nat Med. 2012 Jun; 18(6):856-8. PMID: 22673993.
      View in: PubMed
    62. Kröller-Schön S, Jansen T, Hauptmann F, Schüler A, Heeren T, Hausding M, Oelze M, Viollet B, Keaney JF, Wenzel P, Daiber A, Münzel T, Schulz E. a1AMP-activated protein kinase mediates vascular protective effects of exercise. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1632-41. PMID: 22539595.
      View in: PubMed
    63. Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF, Vita JA, Hamburg NM. Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. Vasc Med. 2012 Apr; 17(2):101-7. PMID: 22496207.
      View in: PubMed
    64. Keaney JF. Immune modulation of atherosclerosis. Circulation. 2011 Nov 29; 124(22):e559-60. PMID: 22125193.
      View in: PubMed
    65. Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, Khuseyinova N, Schnabel RB, Rice KM, Rivadeneira F, Hoogeveen RC, Fontes JD, Meisinger C, Keaney JF, Lemaitre R, Aulchenko YS, Vasan RS, Ellis S, Hazen SL, van Duijn CM, Nelson JJ, März W, Schunkert H, McPherson RM, Stirnadel-Farrant HA, Psaty BM, Gieger C, Siscovick D, Hofman A, Illig T, Cushman M, Yamamoto JF, Rotter JI, Larson MG, Stewart AF, Boerwinkle E, Witteman JC, Tracy RP, Koenig W, Benjamin EJ, Ballantyne CM. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. Eur Heart J. 2012 Jan; 33(2):238-51. PMID: 22003152.
      View in: PubMed
    66. Aurigemma GP, Keaney JF. Renin-angiotensin system inhibition for aortic stenosis "A II, Bruté?". J Am Coll Cardiol. 2011 Aug 2; 58(6):577-80. PMID: 21798418.
      View in: PubMed
    67. Craige SM, Chen K, Pei Y, Li C, Huang X, Chen C, Shibata R, Sato K, Walsh K, Keaney JF. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation. 2011 Aug 9; 124(6):731-40. PMID: 21788590.
      View in: PubMed
    68. Cooper MP, Keaney JF. Epigenetic control of angiogenesis via DNA methylation. Circulation. 2011 Jun 28; 123(25):2916-8. PMID: 21670233.
      View in: PubMed
    69. Sugamura K, Keaney JF. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 2011 Sep 1; 51(5):978-92. PMID: 21627987.
      View in: PubMed
    70. Ward NC, Chen K, Li C, Croft KD, Keaney JF. Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. Clin Exp Pharmacol Physiol. 2011 May; 38(5):328-33. PMID: 21388435.
      View in: PubMed
    71. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJ, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RY, Schnabel RB, Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJ, Pankow J, Elliott P, Keaney JF, Sun W, Sarin AP, Fontes JD, Badola S, Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer zu Schwabedissen HE, Thiery J, Jamshidi Y, Nolte IM, Soranzo N, Spector TD, Völzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I, Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin MR, Rice K, Radke D, Salomaa V, Willems van Dijk K, Boerwinkle E, Vasan RS, Ferrucci L, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Witteman JC, Benjamin EJ, Perola M, Chasman DI. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011 Feb 22; 123(7):731-8. PMID: 21300955.
      View in: PubMed
    72. Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M, Kleschyov AL, Daiber A, Keaney JF, Wegener G, Lackner K, Münzel T, Viollet B, Schulz E. a1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):560-6. PMID: 21205985.
      View in: PubMed
    73. Cheng S, Lyass A, Massaro JM, O'Connor GT, Keaney JF, Vasan RS. Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. Circulation. 2010 Oct 12; 122(15):1470-7. PMID: 20876437.
      View in: PubMed
    74. Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess MA, Levit A, Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF, Vita JA. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin Nutr. 2010 Nov; 92(5):1052-9. PMID: 20844075.
      View in: PubMed
    75. Upadhyay A, Larson MG, Guo CY, Vasan RS, Lipinska I, O'Donnell CJ, Kathiresan S, Meigs JB, Keaney JF, Rong J, Benjamin EJ, Fox CS. Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. Nephrol Dial Transplant. 2011 Mar; 26(3):920-6. PMID: 20682604.
      View in: PubMed
    76. Lieb W, Gona P, Larson MG, Massaro JM, Lipinska I, Keaney JF, Rong J, Corey D, Hoffmann U, Fox CS, Vasan RS, Benjamin EJ, O'Donnell CJ, Kathiresan S. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1849-54. PMID: 20448212.
      View in: PubMed
    77. Lian BQ, Keaney JF. Predicting ischemic heart disease in women: the value of endothelial function. J Am Coll Cardiol. 2010 Apr 20; 55(16):1697-9. PMID: 20394873.
      View in: PubMed
    78. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, Changsirivathanathamrong D, Wu BJ, Ball HJ, Thomas SR, Kapoor V, Celermajer DS, Mellor AL, Keaney JF, Hunt NH, Stocker R. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med. 2010 Mar; 16(3):279-85. PMID: 20190767.
      View in: PubMed
    79. Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, Lu C, Tracy RP, Aleksic N, Heeriga J, Keaney JF, Rice K, Lip GY, Vasan RS, Glazer NL, Larson MG, Uitterlinden AG, Yamamoto J, Durda P, Haritunians T, Psaty BM, Boerwinkle E, Hofman A, Koenig W, Jenny NS, Witteman JC, Ballantyne C, Benjamin EJ. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010 May 1; 19(9):1863-72. PMID: 20167578.
      View in: PubMed
    80. Li C, Keaney JF. AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease. Curr Opin Pharmacol. 2010 Apr; 10(2):111-5. PMID: 20060780.
      View in: PubMed
    81. Schnabel RB, Baumert J, Barbalic M, Dupuis J, Ellinor PT, Durda P, Dehghan A, Bis JC, Illig T, Morrison AC, Jenny NS, Keaney JF, Gieger C, Tilley C, Yamamoto JF, Khuseyinova N, Heiss G, Doyle M, Blankenberg S, Herder C, Walston JD, Zhu Y, Vasan RS, Klopp N, Boerwinkle E, Larson MG, Psaty BM, Peters A, Ballantyne CM, Witteman JC, Hoogeveen RC, Benjamin EJ, Koenig W, Tracy RP. Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators. Blood. 2010 Jul 1; 115(26):5289-99. PMID: 20040767.
      View in: PubMed
    82. Tadros TM, Massaro JM, Rosito GA, Hoffmann U, Vasan RS, Larson MG, Keaney JF, Lipinska I, Meigs JB, Kathiresan S, O'Donnell CJ, Fox CS, Benjamin EJ. Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 2010 May; 18(5):1039-45. PMID: 19875999.
      View in: PubMed
    83. Chen K, Craige SE, Keaney JF. Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal. 2009 Oct; 11(10):2467-80. PMID: 19309256.
      View in: PubMed
    84. Schnabel RB, Larson MG, Yamamoto JF, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Vasan RS, Benjamin EJ. Relation of multiple inflammatory biomarkers to incident atrial fibrillation. Am J Cardiol. 2009 Jul 01; 104(1):92-6. PMID: 19576326.
      View in: PubMed
    85. Schnabel RB, Lunetta KL, Larson MG, Dupuis J, Lipinska I, Rong J, Chen MH, Zhao Z, Yamamoto JF, Meigs JB, Nicaud V, Perret C, Zeller T, Blankenberg S, Tiret L, Keaney JF, Vasan RS, Benjamin EJ. The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations. Circ Cardiovasc Genet. 2009 Jun; 2(3):229-37. PMID: 20031590.
      View in: PubMed
    86. Craige SE, Keaney JF. Polyploidy and dysregulated ROS signaling: the school of hard Nox? Cell Cycle. 2009 Mar 15; 8(6):797. PMID: 19279401.
      View in: PubMed
    87. Keaney JF, Weaver DR. Vascular rhythms and adaptation: do your arteries know what time it is? Circulation. 2009 Mar 24; 119(11):1463-6. PMID: 19273717.
      View in: PubMed
    88. Schnabel R, Dupuis J, Larson MG, Lunetta KL, Robins SJ, Zhu Y, Rong J, Yin X, Stirnadel HA, Nelson JJ, Wilson PW, Keaney JF, Vasan RS, Benjamin EJ. Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study. Atherosclerosis. 2009 Jun; 204(2):601-7. PMID: 19135199.
      View in: PubMed
    89. Keaney JF, Lipinska I, Larson MG, Dupuis J, Freedman JE, Hamburg NM, Massaro JM, Rong J, Sutherland P, Vita JA, Vasan RS, Benjamin EJ. Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J. 2008 Nov; 156(5):1003-1009.e1. PMID: 19061720.
      View in: PubMed
    90. Schulz E, Dopheide J, Schuhmacher S, Thomas SR, Chen K, Daiber A, Wenzel P, Münzel T, Keaney JF. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation. 2008 Sep 23; 118(13):1347-57. PMID: 18809807.
      View in: PubMed
    91. Murabito JM, Keyes MJ, Guo CY, Keaney JF, Vasan RS, D'Agostino RB, Benjamin EJ. Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study. Atherosclerosis. 2009 Apr; 203(2):509-14. PMID: 18701106.
      View in: PubMed
    92. Chen K, Kirber MT, Xiao H, Yang Y, Keaney JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol. 2008 Jun 30; 181(7):1129-39. PMID: 18573911.
      View in: PubMed
    93. Ingelsson E, Larson MG, Yin X, Wang TJ, Meigs JB, Lipinska I, Benjamin EJ, Keaney JF, Vasan RS. Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. J Clin Endocrinol Metab. 2008 Aug; 93(8):3149-57. PMID: 18492761.
      View in: PubMed
    94. Schnabel R, Larson MG, Dupuis J, Lunetta KL, Lipinska I, Meigs JB, Yin X, Rong J, Vita JA, Newton-Cheh C, Levy D, Keaney JF, Vasan RS, Mitchell GF, Benjamin EJ. Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension. 2008 Jun; 51(6):1651-7. PMID: 18426996.
      View in: PubMed
    95. Levitzky YS, Guo CY, Rong J, Larson MG, Walter RE, Keaney JF, Sutherland PA, Vasan A, Lipinska I, Evans JC, Benjamin EJ. Relation of smoking status to a panel of inflammatory markers: the framingham offspring. Atherosclerosis. 2008 Nov; 201(1):217-24. PMID: 18289552.
      View in: PubMed
    96. Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Kathiresan S, Keaney JF, Vasan RS, Benjamin EJ. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb 01; 167(3):313-20. PMID: 18006902.
      View in: PubMed
    97. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2650-6. PMID: 17932315.
      View in: PubMed
    98. Kirber MT, Chen K, Keaney JF. YFP photoconversion revisited: confirmation of the CFP-like species. Nat Methods. 2007 Oct; 4(10):767-8. PMID: 17901864.
      View in: PubMed
    99. Walter RE, Wilk JB, Larson MG, Vasan RS, Keaney JF, Lipinska I, O'Connor GT, Benjamin EJ. Systemic inflammation and COPD: the Framingham Heart Study. Chest. 2008 Jan; 133(1):19-25. PMID: 17908709.
      View in: PubMed
    100. Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF, Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA, Wang TJ, Wilson PW, Wolf PA, Vasan RS. Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S11. PMID: 17903293.
      View in: PubMed
    101. Huang AL, Silver AE, Shvenke E, Schopfer DW, Jahangir E, Titas MA, Shpilman A, Menzoian JO, Watkins MT, Raffetto JD, Gibbons G, Woodson J, Shaw PM, Dhadly M, Eberhardt RT, Keaney JF, Gokce N, Vita JA. Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2113-9. PMID: 17717291.
      View in: PubMed
    102. Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF, Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O'Donnell CJ, Benjamin EJ, Fox CS. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11; 116(11):1234-41. PMID: 17709633.
      View in: PubMed
    103. Meigs JB, Larson MG, Fox CS, Keaney JF, Vasan RS, Benjamin EJ. Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Diabetes Care. 2007 Oct; 30(10):2529-35. PMID: 17586736.
      View in: PubMed
    104. Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, D'Agostino RB, Lipinska I, Keaney JF, Benjamin EJ, O'Donnell CJ. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol. 2007 Jun 1; 99(11):1598-602. PMID: 17531588.
      View in: PubMed
    105. McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF, Vita JA. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich). 2007 Apr; 9(4):249-55. PMID: 17396066.
      View in: PubMed
    106. Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF, Vita JA. Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr. 2007 Apr; 26(2):95-102. PMID: 17536120.
      View in: PubMed
    107. Ingelsson E, Larson MG, Fox CS, Yin X, Wang TJ, Lipinska I, Pou KM, Hoffmann U, Benjamin EJ, Keaney JF, Vasan RS. Clinical correlates of circulating visfatin levels in a community-based sample. Diabetes Care. 2007 May; 30(5):1278-80. PMID: 17261750.
      View in: PubMed
    108. Thomas SR, Schulz E, Keaney JF. Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress. Free Radic Biol Med. 2006 Aug 15; 41(4):681-8. PMID: 16864001.
      View in: PubMed
    109. Fox CS, Guo CY, Larson MG, Vasan RS, Parise H, O'Donnell CJ, D'Agostino RB, Keaney JF, Benjamin EJ. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol. 2006 May 15; 97(10):1502-5. PMID: 16679093.
      View in: PubMed
    110. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF, Wilson PW, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23. PMID: 16534007.
      View in: PubMed
    111. Kotlyar E, Vita JA, Winter MR, Awtry EH, Siwik DA, Keaney JF, Sawyer DB, Cupples LA, Colucci WS, Sam F. The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure. J Card Fail. 2006 Mar; 12(2):122-7. PMID: 16520260.
      View in: PubMed
    112. Dhingra R, Larson MG, Benjamin EJ, Lipinska I, Gona P, Corey D, Keaney JF, Vasan RS. Cross-sectional correlates of serum heat shock protein 70 in the community. Am J Hypertens. 2006 Feb; 19(2):227-31; discussion 232-3. PMID: 16448898.
      View in: PubMed
    113. Shapira OM, Eskenazi BR, Anter E, Joseph L, Christensen TG, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF. Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit. J Thorac Cardiovasc Surg. 2006 Feb; 131(2):388-94. PMID: 16434269.
      View in: PubMed
    114. Keaney JF. Oxidative stress and the vascular wall: NADPH oxidases take center stage. Circulation. 2005 Oct 25; 112(17):2585-8. PMID: 16246957.
      View in: PubMed
    115. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20. PMID: 16116069.
      View in: PubMed
    116. Keaney JF. Circulating biomarkers in acute coronary syndromes: something different or more of the same? Circulation. 2005 Aug 9; 112(6):778-80. PMID: 16087806.
      View in: PubMed
    117. Song Y, Jones JE, Beppu H, Keaney JF, Loscalzo J, Zhang YY. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation. 2005 Jul 26; 112(4):553-62. PMID: 16027259.
      View in: PubMed
    118. Schulz E, Anter E, Zou MH, Keaney JF. Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation. 2005 Jun 28; 111(25):3473-80. PMID: 15967841.
      View in: PubMed
    119. Anter E, Chen K, Shapira OM, Karas RH, Keaney JF. p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res. 2005 May 27; 96(10):1072-8. PMID: 15879307.
      View in: PubMed
    120. Wendt MC, Daiber A, Kleschyov AL, Mülsch A, Sydow K, Schulz E, Chen K, Keaney JF, Lassègue B, Walter U, Griendling KK, Münzel T. Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radic Biol Med. 2005 Aug 1; 39(3):381-91. PMID: 15993337.
      View in: PubMed
    121. Dupuis J, Larson MG, Vasan RS, Massaro JM, Wilson PW, Lipinska I, Corey D, Vita JA, Keaney JF, Benjamin EJ. Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. Atherosclerosis. 2005 Oct; 182(2):307-14. PMID: 16159603.
      View in: PubMed
    122. Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF. EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H99-H107. PMID: 15734884.
      View in: PubMed
    123. Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, Keaney JF, Frei B, Vita JA. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med. 2005 Feb 15; 38(4):499-506. PMID: 15649652.
      View in: PubMed
    124. Gokce N, Vita JA, McDonnell M, Forse AR, Istfan N, Stoeckl M, Lipinska I, Keaney JF, Apovian CM. Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am J Cardiol. 2005 Jan 15; 95(2):266-8. PMID: 15642566.
      View in: PubMed
    125. Huang A, Zhang YY, Chen K, Hatakeyama K, Keaney JF. Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ Res. 2005 Feb 4; 96(2):164-71. PMID: 15604419.
      View in: PubMed
    126. Vita JA, Keaney JF, Larson MG, Keyes MJ, Massaro JM, Lipinska I, Lehman BT, Fan S, Osypiuk E, Wilson PW, Vasan RS, Mitchell GF, Benjamin EJ. Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation. 2004 Dec 7; 110(23):3604-9. PMID: 15569842.
      View in: PubMed
    127. Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9. PMID: 15504342.
      View in: PubMed
    128. Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004 Oct; 84(4):1381-478. PMID: 15383655.
      View in: PubMed
    129. Anter E, Thomas SR, Schulz E, Shapira OM, Vita JA, Keaney JF. Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem. 2004 Nov 5; 279(45):46637-43. PMID: 15333638.
      View in: PubMed
    130. Stocker R, Huang A, Jeranian E, Hou JY, Wu TT, Thomas SR, Keaney JF. Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):2028-33. PMID: 15331437.
      View in: PubMed
    131. Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, Penn MS, Keaney JF, Hazen SL. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004 Aug 31; 110(9):1134-9. PMID: 15326065.
      View in: PubMed
    132. Chen Z, Keaney JF, Schulz E, Levison B, Shan L, Sakuma M, Zhang X, Shi C, Hazen SL, Simon DI. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):13014-9. PMID: 15316118.
      View in: PubMed
    133. Mitchell GF, Parise H, Vita JA, Larson MG, Warner E, Keaney JF, Keyes MJ, Levy D, Vasan RS, Benjamin EJ. Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study. Hypertension. 2004 Aug; 44(2):134-9. PMID: 15249547.
      View in: PubMed
    134. Keaney JF, Massaro JM, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Sutherland P, Vita JA, Benjamin EJ. Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study. J Am Coll Cardiol. 2004 Jul 7; 44(1):168-73. PMID: 15234428.
      View in: PubMed
    135. Chen K, Thomas SR, Albano A, Murphy MP, Keaney JF. Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem. 2004 Aug 13; 279(33):35079-86. PMID: 15180991.
      View in: PubMed
    136. Schulz E, Anter E, Keaney JF. Oxidative stress, antioxidants, and endothelial function. Curr Med Chem. 2004 May; 11(9):1093-104. PMID: 15134508.
      View in: PubMed
    137. Chen K, Keaney J. Reactive oxygen species-mediated signal transduction in the endothelium. Endothelium. 2004 Mar-Apr; 11(2):109-21. PMID: 15370070.
      View in: PubMed
    138. Heydrick SJ, Weiss N, Thomas SR, Cap AP, Pimentel DR, Loscalzo J, Keaney JF. L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. Free Radic Biol Med. 2004 Mar 1; 36(5):632-40. PMID: 14980706.
      View in: PubMed
    139. Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF, Lehman BT, Fan S, Osypiuk E, Vita JA. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation. 2004 Feb 10; 109(5):613-9. PMID: 14769683.
      View in: PubMed
    140. Sydow K, Daiber A, Oelze M, Chen Z, August M, Wendt M, Ullrich V, Mülsch A, Schulz E, Keaney JF, Stamler JS, Münzel T. Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. J Clin Invest. 2004 Feb; 113(3):482-9. PMID: 14755345.
      View in: PubMed
    141. Widlansky ME, Biegelsen ES, Hamburg NM, Duffy SJ, Keaney JF, Vita JA. Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid. Free Radic Biol Med. 2004 Jan 1; 36(1):123-30. PMID: 14732296.
      View in: PubMed
    142. Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med. 2003 Nov; 41(11):1455-61. PMID: 14656025.
      View in: PubMed
    143. Widlansky ME, Gokce N, Keaney JF, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003 Oct 1; 42(7):1149-60. PMID: 14522472.
      View in: PubMed
    144. Chen K, Albano A, Ho A, Keaney JF. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J Biol Chem. 2003 Oct 10; 278(41):39527-33. PMID: 12890678.
      View in: PubMed
    145. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Keaney JF, Creager MA. Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2392-8. PMID: 12881209.
      View in: PubMed
    146. Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF, Morrow JD, Vita JA. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension. 2003 Sep; 42(3):310-5. PMID: 12874094.
      View in: PubMed
    147. Chen K, Thomas SR, Keaney JF. Beyond LDL oxidation: ROS in vascular signal transduction. Free Radic Biol Med. 2003 Jul 15; 35(2):117-32. PMID: 12853068.
      View in: PubMed
    148. Gokce N, Keaney JF, Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO, Vita JA. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol. 2003 May 21; 41(10):1769-75. PMID: 12767663.
      View in: PubMed
    149. Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, Pearce GL, Gokce N, Keaney JF, Penn MS, Sprecher DL, Vita JA, Hazen SL. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA. 2003 Apr 2; 289(13):1675-80. PMID: 12672736.
      View in: PubMed
    150. Thomas SR, Chen K, Keaney JF. Oxidative stress and endothelial nitric oxide bioactivity. Antioxid Redox Signal. 2003 Apr; 5(2):181-94. PMID: 12716478.
      View in: PubMed
    151. Vita JA, Gokce N, Duffy SJ, Kahn D, Tomasian D, Palmisano J, Thomas S, Holbrook M, Keaney JF. Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease. Am J Cardiol. 2003 Apr 1; 91(7):857-60. PMID: 12667571.
      View in: PubMed
    152. Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA. Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function. Am J Cardiol. 2003 Mar 15; 91(6):732-5. PMID: 12633811.
      View in: PubMed
    153. Keaney JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 2003 Mar 1; 23(3):434-9. PMID: 12615693.
      View in: PubMed
    154. Gokce N, Holbrook M, Hunter LM, Palmisano J, Vigalok E, Keaney JF, Vita JA. Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol. 2002 Aug 21; 40(4):761-5. PMID: 12204508.
      View in: PubMed
    155. Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF, Walsh K. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem. 2002 Nov 1; 277(44):41888-96. PMID: 12167628.
      View in: PubMed
    156. Vita JA, Keaney JF. Endothelial function: a barometer for cardiovascular risk? Circulation. 2002 Aug 6; 106(6):640-2. PMID: 12163419.
      View in: PubMed
    157. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, O'Malley C, Keaney JF, Balady GJ. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol. 2002 Jul 15; 90(2):124-7. PMID: 12106840.
      View in: PubMed
    158. Keaney JF, Vita JA. The value of inflammation for predicting unstable angina. N Engl J Med. 2002 Jul 4; 347(1):55-7. PMID: 12097542.
      View in: PubMed
    159. Keaney JF, Vita JA. Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say? J Cardiopulm Rehabil. 2002 Jul-Aug; 22(4):225-33. PMID: 12202841.
      View in: PubMed
    160. Nicolosi RJ, Wilson TA, Handelman G, Foxall T, Keaney JF, Vita JA. Decreased aortic early atherosclerosis in hypercholesterolemic hamsters fed oleic acid-rich TriSun oil compared to linoleic acid-rich sunflower oil. J Nutr Biochem. 2002 Jul; 13(7):392-402. PMID: 12121826.
      View in: PubMed
    161. Gokce N, Keaney JF, Hunter LM, Watkins MT, Menzoian JO, Vita JA. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation. 2002 Apr 2; 105(13):1567-72. PMID: 11927524.
      View in: PubMed
    162. Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6. PMID: 11832341.
      View in: PubMed
    163. Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J. Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem J. 2002 Jan 15; 361(Pt 2):267-76. PMID: 11772398.
      View in: PubMed
    164. Huang A, Thomas SR, Keaney JF. Measurements of redox control of nitric oxide bioavailability. Methods Enzymol. 2002; 359:209-16. PMID: 12481573.
      View in: PubMed
    165. Visioli F, Smith A, Zhang W, Keaney JF, Hagen T, Frei B. Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. Redox Rep. 2002; 7(4):223-7. PMID: 12396668.
      View in: PubMed
    166. Thomas SR, Chen K, Keaney JF. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem. 2002 Feb 22; 277(8):6017-24. PMID: 11744698.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Keaney's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _