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John F Keaney MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-334-2266
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABBiochemistry/Molecular Biology
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Overview 
    Collapse overview

    Education:

    • 1983 A.B. Harvard College
    • 1987 M.D. Yale University School of Medicine

    Postdoctoral Training

    Internship and Residency:
    • 1987-1988 Intern in Medicine, Brigham & Women's Hospital, Boston, MA
    • 1988-1989 Junior Assistant Resident, Brigham & Women's Hospital, Boston, MA
    Fellowship:
    • 1989-1990 Clinical Fellow, Cardiology, Brigham & Women's Hospital, Boston, MA
    • 1990-1992 Clinical and Research Fellow in Cardiology, Brigham & Women's Hospital, Boston, MA

    Licensure and Certification

    • 1988 Diplomate, National Board of Medical Examiners
    • 1989 Massachusetts Medical License, No. 70338
    • 1991 Diplomate, American Board of Internal Medicine
    • 1993 Diplomate, Subspecialty in Cardiovascular Diseases
    • 1995 Certification: Palmaz-Schatz stent implantation
    • 1999 ABIM Certification in Interventional Cardiology
    • 2001 ABIM Recertification in Internal Medicine and Cardiology

    Memberships in Professional Societies

    • 1984- Massachusetts Medical Society
    • 1984- Norfolk County Medical Society
    • 1992- American Association for the Advancement of Science
    • 1992- American Federation for Clinical Research
    • 1992- American College of Physicians
    • 1996- Fellow, American College of Cardiology
    • 1996- American Physiological Society
    • 1996- Fellow, American Heart Association, Council on Arteriosclerosis.
    • 1997- Fellow, American Heart Association, Council on Circulation
    • 1998- Society for Free Radical Biology in Medicine
    • 2001- Fellow, American Heart Association
    • 2001- American Society of Biochemistry and Molecular Biology
    • 2006- American Society of Clinical Investigation
    • 2007- Association of University Cardiologists

    John F Keaney,  JrJohn F. Keaney, Jr, MD

    Division Chief, Cardiovascular Medicine
    Department of Medicine
    University of Massachusetts Medical School

    Research Grants

    • 1992-1994 F32HL08635, National Research Service Award, NIH
    • 1994-1995 Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
    • 1994-1996 Grant-in-Aid, American Heart Association, Mass. Affiliate
    • 1995-2000 K08HL03195, Clinical Investigator Development Award, NIH
    • 1995-1998 Research Grant, Council for Tobacco Research, USA #4073
    • 1996-1999 Grant-in-Aid, American Heart Association, National Center
    • 1996-2001 P01HL55854, Project Leader, Mechanism(s) of Excess LDL Oxidation in Diabetes, NIH
    • 1997-2000 R01HL59634, Vitamin C, GSH, and Endothelium-Derived NO, NIH
    • 1997-2001 R01HL58936, Homocysteine, Oxidative Stress, and Nitric Oxide, NIH
    • 2000-2004 R01DK55656, Cellular Vitamin E Status and Integrin Function, NIH
    • 2000-2004 Established Investigator Award, American Heart Association
    • 2000-2005 P01HL60886, Project Leader, Vitamin C, GSH, and EDNO, NIH
    • 2001-2006 T32HL07224-30, Basic Science Cardiovascular Training Program
    • 2002-2005 Oxidative Stress, AMP kinase, and EDNO (Project 2), NIH/NHLBI and JDRF Center for Study of Diabetic Complications
    • 2003-2008 R01HL61766, HOCl-Mediated Impairment of Endothelial Function, NIH
    • 2005-2010 R01AG027081, Nox Isoforms in the Control of Endothelial Cell Phenotype
    • 2005-2010 P01HL81587, Endothelial Redox State and Phenotype in Health and Disease
    • 2009-2012 RO1HL09122, Mitochondrial Biogenesis and Endothelial Cell Phenotype, NIH
    • 2010-2014 RO1HL098407, Nox4 and Vascular Homeostasis

    Awards and Honors

    • 1983Magna Cum Laude, Harvard College
    • 1987Cum Laude, Yale University School of Medicine
    • 1987Alpha Omega Alpha
    • 1987Norma Bailey Berniker Prize, Yale University School of Medicine
    • 1987Merck Merit Award, Yale University School of Medicine
    • 1992Merck/ACC Research Fellow Award, American College of Cardiology
    • 1992National Research Service Award, National Institutes of Health.
    • 1992Ignacio Chavez Young Investigator Award, XIV InterAmerican Congress of Cardiology, Orlando, FL
    • 1994Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
    • 1995Clinical Investigator Development Award, National Institutes of Health
    • 1997Ad Hoc Member, Experimental Cardiovascular Sciences Study Section, NIH
    • 1998Ad Hoc Member, Nutrition Study Section, NIH
    • 2000Established Investigator Award, American Heart Association
    • 2001Co-Chair, Cardiorenal Grant Review Panel, AHA New England Affiliate
    • 2002Chair, Cardiorenal Review Panel, AHA Northeast Region
    • 2003Young Investigator Award Review Panel, The Medical Foundation, Boston, MA
    • 2004Ad Hoc Member, Atherosclerosis and Inflammation Study Section, NIH
    • 2004-2007 Charter Member, Vascular Cell and Molecular Biology Study Section, NIH
    • 2004-Associate Editor, Circulation
    • 2005Outstanding Medical Student Mentor, Boston University School of Medicine
    • 2006American Society for Clinical Investigation
    • 2006-Charter Member and Chair, Molecular Signaling Review Panel, AHA National Center
    • 2007-Association of University Cardiologists
    • 2012-Deputy Editor, Journal of the American Heart Association
    • 2012-Chair, Research Committee, AHA Founder's Affiliate



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Craige S, Chen K, Blanton R, Keaney J, Kant S. JNK and cardiometabolic dysfunction. Biosci Rep. 2019 Jul 03. PMID: 31270248.
      View in: PubMed
    2. Min SY, Learnard H, Kant S, Gealikman O, Rojas-Rodriguez R, DeSouza T, Desai A, Keaney JF, Corvera S, Craige SM. Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue. Int J Mol Sci. 2019 Apr 25; 20(8). PMID: 31027261.
      View in: PubMed
    3. Münzel T, Hahad O, Gori T, Hollmann S, Arnold N, Prochaska JH, Schulz A, Beutel M, Pfeiffer N, Schmidtmann I, Lackner KJ, Keaney JF, Wild PS. Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study. Clin Res Cardiol. 2019 Apr 05. PMID: 30953178.
      View in: PubMed
    4. Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E. Endothelial a1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction. Basic Res Cardiol. 2019 Jan 14; 114(2):8. PMID: 30643968.
      View in: PubMed
    5. Keaney JF, Rosen CJ. VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease. N Engl J Med. 2018 Nov 10. PMID: 30415594.
      View in: PubMed
    6. Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF, Vasan RS, Benjamin EJ, Mittleman MA. Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study. Environ Res. 2018 Oct 28; 171:36-43. PMID: 30654247.
      View in: PubMed
    7. Hendrix RJ, Bello RA, Flahive JM, Kakouros N, Aurigemma GP, Keaney JF, Hoffman W, Vassileva CM. Mitral valve repair vs replacement in elderly with degenerative disease: Analysis of the STS Adult Cardiac Surgery Database. Ann Thorac Surg. 2018 Oct 26. PMID: 30612990.
      View in: PubMed
    8. Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF, Münzel T, Wenzel P, Schulz E. a1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction. Cardiovasc Res. 2018 Jul 04. PMID: 29982418.
      View in: PubMed
    9. Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G. First experience with zero-fluoroscopic ablation for supraventricular tachycardias using a novel impedance and magnetic-field-based mapping system. Clin Res Cardiol. 2018 Jul; 107(7):578-585. PMID: 29476203.
      View in: PubMed
    10. Conlon R, Tanner R, David S, Szeplaki G, Galvin J, Keaney J, Keelan E, Boles U. Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia. Cardiol Res. 2017 Dec; 8(6):280-285. PMID: 29317970.
      View in: PubMed
    11. Walsh KA, Galvin J, Keaney J, Keelan E, Szeplaki G. Automated ultra-high-density mapping of peri-sinus node premature atrial contractions. Clin Res Cardiol. 2018 Apr; 107(4):368-370. PMID: 29222593.
      View in: PubMed
    12. Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF, Trivedi CM. Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Oct 16. PMID: 29035278.
      View in: PubMed
    13. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF, Zile MR, Aurigemma GP. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 2017; 4:49. PMID: 28824923.
      View in: PubMed
    14. Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney JF, Vasan RS, Benjamin EJ, Mittleman MA. Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1793-1800. PMID: 28751572.
      View in: PubMed
    15. Zachariah JP, Quiroz R, Nelson KP, Teng Z, Keaney JF, Sullivan LM, Vasan RS. Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study. J Am Heart Assoc. 2017 Jul 16; 6(7). PMID: 28713076.
      View in: PubMed
    16. Zachariah JP, Quiroz R, Enserro D, Andersson C, Keaney JF, Sullivan LM, Vasan RS. Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring. J Am Heart Assoc. 2017 Jul 16; 6(7). PMID: 28713075.
      View in: PubMed
    17. Keaney JF. CHIP-ping Away at Atherosclerosis. N Engl J Med. 2017 Jun 21. PMID: 28636833.
      View in: PubMed
    18. Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF, Cooper MP. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017 May 17; 7(1):2013. PMID: 28515438.
      View in: PubMed
    19. Szeplaki G, Keaney J, Keelan E, Valentine J, Galvin J. Isolation of the superior vena cava to block unidirectional exit conduction from the right-sided pulmonary veins during atrial fibrillation ablation. J Interv Card Electrophysiol. 2017 Apr 08. PMID: 28391548.
      View in: PubMed
    20. Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF. PGC-1a dictates endothelial function through regulation of eNOS expression. Sci Rep. 2016 Dec 02; 6:38210. PMID: 27910955.
      View in: PubMed
    21. Sullivan LM, Weinberg J, Keaney JF. Common Statistical Pitfalls in Basic Science Research. J Am Heart Assoc. 2016 Sep 29; 5(10). PMID: 27688237.
      View in: PubMed
    22. Ramo K, Sugamura K, Craige S, Keaney JF, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 2016 Aug 09; 5. PMID: 27504807.
      View in: PubMed
    23. Lee JJ, Britton KA, Pedley A, Massaro JM, Speliotes EK, Murabito JM, Hoffmann U, Ingram C, Keaney JF, Vasan RS, Fox CS. Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation. J Am Heart Assoc. 2016 May; 5(5). PMID: 27146446.
      View in: PubMed
    24. Li W, Wilker EH, Dorans KS, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Keaney JF, Lin H, Vasan RS, Benjamin EJ, Mittleman MA. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study. J Am Heart Assoc. 2016 May; 5(5). PMID: 27126478.
      View in: PubMed
    25. Zhang CH, Wang P, Liu DH, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Lu P, Zheng K, Craige SM, Lifshitz LM, Keaney JF, Fogarty KE, ZhuGe R, Zhu MS. The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun. 2016 Apr 22; 7:11358. PMID: 27101932.
      View in: PubMed
    26. Keaney JF, Solomon CG. Postmenopausal Hormone Therapy and Atherosclerosis--Time Is of the Essence. N Engl J Med. 2016 Mar 31; 374(13):1279-80. PMID: 27028919.
      View in: PubMed
    27. Li C, Reif MM, Craige SM, Kant S, Keaney JF. Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016 May 1; 55-56:45-53. PMID: 26989010.
      View in: PubMed
    28. Lee JJ, Pedley A, Hoffmann U, Massaro JM, Keaney JF, Vasan RS, Fox CS. Cross-Sectional Associations of Computed Tomography (CT)-Derived Adipose Tissue Density and Adipokines: The Framingham Heart Study. J Am Heart Assoc. 2016 Feb 29; 5(3):e002545. PMID: 26927600.
      View in: PubMed
    29. Khurshid S, Keaney J, Ellinor PT, Lubitz SA. A Simple and Portable Algorithm for Identifying Atrial Fibrillation in the Electronic Medical Record. Am J Cardiol. 2016 Jan 15; 117(2):221-5. PMID: 26684516.
      View in: PubMed
    30. Phillips RA, Cyr J, Keaney JF, Messina LM, Meyer TE, Tam SK, Korenda K, Darrigo M, Kumar P, Challapalli S. Creating and Maintaining a Successful Service Line in an Academic Medical Center at the Dawn of Value-Based Care: Lessons Learned From the Heart and Vascular Service Line at UMass Memorial Health Care. Acad Med. 2015 Oct; 90(10):1340-6. PMID: 26222322.
      View in: PubMed
    31. Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron. 2015 Sep 23; 87(6):1215-33. PMID: 26402605.
      View in: PubMed
    32. Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF. Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med. 2015 Dec; 89:1-7. PMID: 26169727.
      View in: PubMed
    33. Münzel T, Gori T, Keaney JF, Maack C, Daiber A. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur Heart J. 2015 Oct 7; 36(38):2555-64. PMID: 26142467.
      View in: PubMed
    34. Jarcho JA, Keaney JF. Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT. N Engl J Med. 2015 Jun 18; 372(25):2448-50. PMID: 26039520.
      View in: PubMed
    35. Craige SM, Kant S, Keaney JF. Reactive oxygen species in endothelial function - from disease to adaptation - . Circ J. 2015; 79(6):1145-55. PMID: 25986771.
      View in: PubMed
    36. Masterson S, Wright P, O'Donnell C, Vellinga A, Murphy AW, Hennelly D, Sinnott B, Egan J, O'Reilly M, Keaney J, Bury G, Deasy C. Urban and rural differences in out-of-hospital cardiac arrest in Ireland. Resuscitation. 2015 Jun; 91:42-7. PMID: 25818707.
      View in: PubMed
    37. Keaney JF. Balancing the risks and benefits of dual platelet inhibition. N Engl J Med. 2015 May 7; 372(19):1854-6. PMID: 25773507.
      View in: PubMed
    38. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. Circulation. 2015 Jan 27; 131(4):432-3. PMID: 25623127.
      View in: PubMed
    39. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. J Am Heart Assoc. 2015 Jan 26; 4(1):e001778. PMID: 25628411.
      View in: PubMed
    40. Murdoch JD, Gupta AR, Sanders SJ, Walker MF, Keaney J, Fernandez TV, Murtha MT, Anyanwu S, Ober GT, Raubeson MJ, DiLullo NM, Villa N, Waqar Z, Sullivan C, Gonzalez L, Willsey AJ, Choe SY, Neale BM, Daly MJ, State MW. No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins. PLoS Genet. 2015 Jan; 11(1):e1004852. PMID: 25621974.
      View in: PubMed
    41. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF, Donahue JK, Benjamin EJ, Freedman JE. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015 Jan; 12(1):3-10. PMID: 25257092.
      View in: PubMed
    42. Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Rep. 2014 Oct 9; 9(1):16-23. PMID: 25284784.
      View in: PubMed
    43. Keaney JF, Curfman GD, Jarcho JA. The new cholesterol treatment guidelines. N Engl J Med. 2014 May 15; 370(20):1957. PMID: 24827049.
      View in: PubMed
    44. Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O'Donnell CJ, Wolf PA, O'Connor GT, Keaney JF, Vasan RS. Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes. Eur Heart J. 2014 Nov 7; 35(42):2980-7. PMID: 24574370.
      View in: PubMed
    45. Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF, Cooper MP. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest. 2014 Feb; 124(2):768-84. PMID: 24430182.
      View in: PubMed
    46. Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP. Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card Fail. 2014 Jan; 20(1):31-7. PMID: 24333348.
      View in: PubMed
    47. Keaney JF, Curfman GD, Jarcho JA. A pragmatic view of the new cholesterol treatment guidelines. N Engl J Med. 2014 Jan 16; 370(3):275-8. PMID: 24283199.
      View in: PubMed
    48. Hong SN, Gona P, Fontes JD, Oyama N, Chan RH, Kenchaiah S, Tsao CW, Yeon SB, Schnabel RB, Keaney JF, O'Donnell CJ, Benjamin EJ, Manning WJ. Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. J Am Heart Assoc. 2013 Nov 15; 2(6):e000307. PMID: 24242683.
      View in: PubMed
    49. Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD. Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction. Fam Med Med Sci Res. 2013 Oct 1; 2(2):108. PMID: 24432306.
      View in: PubMed
    50. Keaney JF. P2Y12 inhibition in patients with NSTEMI--can later be better? N Engl J Med. 2013 Sep 12; 369(11):1056-7. PMID: 23991623.
      View in: PubMed
    51. McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73. PMID: 23968978.
      View in: PubMed
    52. Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res. 2013 Sep 13; 113(7):891-901. PMID: 23819990.
      View in: PubMed
    53. Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Murabito JM, Vasan RS, Benjamin EJ. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1728-33. PMID: 23640499.
      View in: PubMed
    54. Chami HA, Fontes JD, Vasan RS, Keaney JF, O'Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep. 2013 May 01; 36(5):763-768C. PMID: 23633759.
      View in: PubMed
    55. Fontes JD, Yamamoto JF, Larson MG, Wang N, Dallmeier D, Rienstra M, Schnabel RB, Vasan RS, Keaney JF, Benjamin EJ. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study. Atherosclerosis. 2013 May; 228(1):217-23. PMID: 23489346.
      View in: PubMed
    56. Chen K, Keaney JF. Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease. Curr Atheroscler Rep. 2012 Oct; 14(5):476-83. PMID: 22956414.
      View in: PubMed
    57. Kaess BM, Enserro DM, McManus DD, Xanthakis V, Chen MH, Sullivan LM, Ingram C, O'Donnell CJ, Keaney JF, Vasan RS, Glazer NL. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1943-7. PMID: 22855337.
      View in: PubMed
    58. Dallmeier D, Larson MG, Vasan RS, Keaney JF, Fontes JD, Meigs JB, Fox CS, Benjamin EJ. Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study. Diabetol Metab Syndr. 2012 Jun 20; 4(1):28. PMID: 22716219.
      View in: PubMed
    59. Sugamura K, Keaney JF. Nicotine: linking smoking to abdominal aneurysms. Nat Med. 2012 Jun; 18(6):856-8. PMID: 22673993.
      View in: PubMed
    60. Kröller-Schön S, Jansen T, Hauptmann F, Schüler A, Heeren T, Hausding M, Oelze M, Viollet B, Keaney JF, Wenzel P, Daiber A, Münzel T, Schulz E. a1AMP-activated protein kinase mediates vascular protective effects of exercise. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1632-41. PMID: 22539595.
      View in: PubMed
    61. Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF, Vita JA, Hamburg NM. Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. Vasc Med. 2012 Apr; 17(2):101-7. PMID: 22496207.
      View in: PubMed
    62. Keaney JF. Immune modulation of atherosclerosis. Circulation. 2011 Nov 29; 124(22):e559-60. PMID: 22125193.
      View in: PubMed
    63. Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, Khuseyinova N, Schnabel RB, Rice KM, Rivadeneira F, Hoogeveen RC, Fontes JD, Meisinger C, Keaney JF, Lemaitre R, Aulchenko YS, Vasan RS, Ellis S, Hazen SL, van Duijn CM, Nelson JJ, März W, Schunkert H, McPherson RM, Stirnadel-Farrant HA, Psaty BM, Gieger C, Siscovick D, Hofman A, Illig T, Cushman M, Yamamoto JF, Rotter JI, Larson MG, Stewart AF, Boerwinkle E, Witteman JC, Tracy RP, Koenig W, Benjamin EJ, Ballantyne CM. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. Eur Heart J. 2012 Jan; 33(2):238-51. PMID: 22003152.
      View in: PubMed
    64. Aurigemma GP, Keaney JF. Renin-angiotensin system inhibition for aortic stenosis "A II, Bruté?". J Am Coll Cardiol. 2011 Aug 2; 58(6):577-80. PMID: 21798418.
      View in: PubMed
    65. Craige SM, Chen K, Pei Y, Li C, Huang X, Chen C, Shibata R, Sato K, Walsh K, Keaney JF. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation. 2011 Aug 9; 124(6):731-40. PMID: 21788590.
      View in: PubMed
    66. Cooper MP, Keaney JF. Epigenetic control of angiogenesis via DNA methylation. Circulation. 2011 Jun 28; 123(25):2916-8. PMID: 21670233.
      View in: PubMed
    67. Sugamura K, Keaney JF. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 2011 Sep 1; 51(5):978-92. PMID: 21627987.
      View in: PubMed
    68. Ward NC, Chen K, Li C, Croft KD, Keaney JF. Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. Clin Exp Pharmacol Physiol. 2011 May; 38(5):328-33. PMID: 21388435.
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    148. Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF, Morrow JD, Vita JA. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension. 2003 Sep; 42(3):310-5. PMID: 12874094.
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    149. Chen K, Thomas SR, Keaney JF. Beyond LDL oxidation: ROS in vascular signal transduction. Free Radic Biol Med. 2003 Jul 15; 35(2):117-32. PMID: 12853068.
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    150. Gokce N, Keaney JF, Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO, Vita JA. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol. 2003 May 21; 41(10):1769-75. PMID: 12767663.
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    151. Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, Pearce GL, Gokce N, Keaney JF, Penn MS, Sprecher DL, Vita JA, Hazen SL. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA. 2003 Apr 2; 289(13):1675-80. PMID: 12672736.
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    152. Thomas SR, Chen K, Keaney JF. Oxidative stress and endothelial nitric oxide bioactivity. Antioxid Redox Signal. 2003 Apr; 5(2):181-94. PMID: 12716478.
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    153. Vita JA, Gokce N, Duffy SJ, Kahn D, Tomasian D, Palmisano J, Thomas S, Holbrook M, Keaney JF. Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease. Am J Cardiol. 2003 Apr 1; 91(7):857-60. PMID: 12667571.
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    154. Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA. Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function. Am J Cardiol. 2003 Mar 15; 91(6):732-5. PMID: 12633811.
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    155. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6. PMID: 12546685.
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    156. Keaney JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 2003 Mar 1; 23(3):434-9. PMID: 12615693.
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    157. Gokce N, Holbrook M, Hunter LM, Palmisano J, Vigalok E, Keaney JF, Vita JA. Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol. 2002 Aug 21; 40(4):761-5. PMID: 12204508.
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    158. Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF, Walsh K. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem. 2002 Nov 1; 277(44):41888-96. PMID: 12167628.
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    159. Vita JA, Keaney JF. Endothelial function: a barometer for cardiovascular risk? Circulation. 2002 Aug 6; 106(6):640-2. PMID: 12163419.
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    160. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, O'Malley C, Keaney JF, Balady GJ. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol. 2002 Jul 15; 90(2):124-7. PMID: 12106840.
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    161. Keaney JF, Vita JA. The value of inflammation for predicting unstable angina. N Engl J Med. 2002 Jul 4; 347(1):55-7. PMID: 12097542.
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    162. Keaney JF, Vita JA. Vascular oxidative stress and antioxidant protection in atherosclerosis: what do the clinical trials say? J Cardiopulm Rehabil. 2002 Jul-Aug; 22(4):225-33. PMID: 12202841.
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    163. Nicolosi RJ, Wilson TA, Handelman G, Foxall T, Keaney JF, Vita JA. Decreased aortic early atherosclerosis in hypercholesterolemic hamsters fed oleic acid-rich TriSun oil compared to linoleic acid-rich sunflower oil. J Nutr Biochem. 2002 Jul; 13(7):392-402. PMID: 12121826.
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    164. Gokce N, Keaney JF, Hunter LM, Watkins MT, Menzoian JO, Vita JA. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation. 2002 Apr 2; 105(13):1567-72. PMID: 11927524.
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    165. Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6. PMID: 11832341.
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    166. Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J. Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem J. 2002 Jan 15; 361(Pt 2):267-76. PMID: 11772398.
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    167. Visioli F, Smith A, Zhang W, Keaney JF, Hagen T, Frei B. Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. Redox Rep. 2002; 7(4):223-7. PMID: 12396668.
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    168. Huang A, Thomas SR, Keaney JF. Measurements of redox control of nitric oxide bioavailability. Methods Enzymol. 2002; 359:209-16. PMID: 12481573.
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    169. Thomas SR, Chen K, Keaney JF. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem. 2002 Feb 22; 277(8):6017-24. PMID: 11744698.
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    170. Vita JA, Keaney JF. Hormone replacement therapy and endothelial function: the exception that proves the rule? Arterioscler Thromb Vasc Biol. 2001 Dec; 21(12):1867-9. PMID: 11742856.
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    171. Gokce N, Holbrook M, Duffy SJ, Demissie S, Cupples LA, Biegelsen E, Keaney JF, Loscalzo J, Vita JA. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension. 2001 Dec 1; 38(6):1349-54. PMID: 11751716.
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    172. Upston JM, Witting PK, Brown AJ, Stocker R, Keaney JF. Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits. Free Radic Biol Med. 2001 Nov 15; 31(10):1245-53. PMID: 11705703.
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    173. Münzel T, Keaney JF. Are ACE inhibitors a "magic bullet" against oxidative stress? Circulation. 2001 Sep 25; 104(13):1571-4. PMID: 11571254.
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    174. Huang A, Xiao H, Samii JM, Vita JA, Keaney JF. Contrasting effects of thiol-modulating agents on endothelial NO bioactivity. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C719-25. PMID: 11443071.
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    175. Gokce N, Duffy SJ, Hunter LM, Keaney JF, Vita JA. Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults. Am J Cardiol. 2001 Jul 15; 88(2):153-9. PMID: 11448412.
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    176. Duffy SJ, Keaney JF, Holbrook M, Gokce N, Swerdloff PL, Frei B, Vita JA. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation. 2001 Jul 10; 104(2):151-6. PMID: 11447078.
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    177. Duffy SJ, Biegelsen ES, Holbrook M, Russell JD, Gokce N, Keaney JF, Vita JA. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation. 2001 Jun 12; 103(23):2799-804. PMID: 11401935.
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    178. Duffy SJ, Vita JA, Holbrook M, Swerdloff PL, Keaney JF. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):1084-9. PMID: 11397724.
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    179. Kuohung W, Shwaery GT, Keaney JF. Tamoxifen, esterified estradiol, and physiologic concentrations of estradiol inhibit oxidation of low-density lipoprotein by endothelial cells. Am J Obstet Gynecol. 2001 May; 184(6):1060-3. PMID: 11349156.
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    180. Chen K, Vita JA, Berk BC, Keaney JF. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem. 2001 May 11; 276(19):16045-50. PMID: 11278982.
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    181. Freedman JE, Keaney JF. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J Nutr. 2001 Feb; 131(2):374S-7S. PMID: 11160564.
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    182. Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF, Vita JA. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H528-34. PMID: 11158948.
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    183. Mowri HO, Frei B, Keaney JF. Glucose enhancement of LDL oxidation is strictly metal ion dependent. Free Radic Biol Med. 2000 Nov 1; 29(9):814-24. PMID: 11063907.
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    184. Shapira OM, Alkon JD, Macron DS, Keaney JF, Vita JA, Aldea GS, Shemin RJ. Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm. Ann Thorac Surg. 2000 Sep; 70(3):883-8; discussion 888-9. PMID: 11016328.
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    185. Visioli F, Keaney JF, Halliwell B. Antioxidants and cardiovascular disease; panaceas or tonics for tired sheep? Cardiovasc Res. 2000 Aug 18; 47(3):409. PMID: 10963713.
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    186. Tomasian D, Keaney JF, Vita JA. Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res. 2000 Aug 18; 47(3):426-35. PMID: 10963716.
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    187. Xu A, Vita JA, Keaney JF. Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione. Hypertension. 2000 Aug; 36(2):291-5. PMID: 10948092.
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    188. Keaney JF. Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction. Mol Aspects Med. 2000 Aug-Oct; 21(4-5):99-166. PMID: 11044550.
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    189. Huang A, Vita JA, Venema RC, Keaney JF. Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem. 2000 Jun 9; 275(23):17399-406. PMID: 10749876.
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    190. Sherman DL, Keaney JF, Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension. 2000 Apr; 35(4):936-41. PMID: 10775565.
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    191. Vita JA, Keaney JF. Exercise--toning up the endothelium? N Engl J Med. 2000 Feb 17; 342(7):503-5. PMID: 10675433.
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    192. Price DT, Vita JA, Keaney JF. Redox control of vascular nitric oxide bioavailability. Antioxid Redox Signal. 2000; 2(4):919-35. PMID: 11213492.
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    193. Loscalzo J, Freedman J, Inbal A, Keaney JF, Michelson AD, Vita JA. Nitric oxide insufficiency and arterial thrombosis. Trans Am Clin Climatol Assoc. 2000; 111:158-63. PMID: 10881340.
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    194. Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF, Vita JA. Treatment of hypertension with ascorbic acid. Lancet. 1999 Dec 11; 354(9195):2048-9. PMID: 10636373.
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    195. Shapira OM, Xu A, Aldea GS, Vita JA, Shemin RJ, Keaney JF. Enhanced nitric oxide-mediated vascular relaxation in radial artery compared with internal mammary artery or saphenous vein. Circulation. 1999 Nov 9; 100(19 Suppl):II322-7. PMID: 10567323.
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    196. Gokce N, Keaney JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1999 Jun 29; 99(25):3234-40. PMID: 10385496.
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    197. Keaney JF, Simon DI, Freedman JE. Vitamin E and vascular homeostasis: implications for atherosclerosis. FASEB J. 1999 Jun; 13(9):965-75. PMID: 10336880.
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    198. Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF. Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator. J Thorac Cardiovasc Surg. 1999 May; 117(5):906-11. PMID: 10220683.
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    199. Ceriello A, Keaney JF, Vita JA. Vitamin C and endothelial dysfunction: what is new? Circulation. 1999 Mar 9; 99(9):1273-4. PMID: 10069926.
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    200. Keaney JF, Loscalzo J. Diabetes, oxidative stress, and platelet activation. Circulation. 1999 Jan 19; 99(2):189-91. PMID: 9892579.
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    201. Shwaery GT, Samii JM, Frei B, Keaney JF. Determination of phospholipid oxidation in cultured cells. Methods Enzymol. 1999; 300:51-7. PMID: 9919508.
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    202. Freedman JE, Keaney JF. Nitric oxide and superoxide detection in human platelets. Methods Enzymol. 1999; 301:61-70. PMID: 9919554.
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    203. Shwaery GT, Mowri H, Keaney JF, Frei B. Preparation of lipid hydroperoxide-free low-density lipoproteins. Methods Enzymol. 1999; 300:17-23. PMID: 9919504.
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    204. Jackson TS, Xu A, Vita JA, Keaney JF. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res. 1998 Nov 2; 83(9):916-22. PMID: 9797340.
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    205. Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 1998 Oct 13; 98(15):1481-6. PMID: 9769300.
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    206. Polidori MC, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney JF, Schwamm L, Mecocci P, Koroshetz WJ, Beal MF. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radic Biol Med. 1998 Sep; 25(4-5):561-7. PMID: 9741593.
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    207. Lazar HL, Volpe C, Bao Y, Rivers S, Vita JA, Keaney JF. Beneficial effects of angiotensin-converting enzyme inhibitors during acute revascularization. Ann Thorac Surg. 1998 Aug; 66(2):487-92. PMID: 9725390.
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    208. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol. Atherosclerosis. 1998 Jun; 138(2):255-62. PMID: 9690908.
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    209. Vita JA, Keaney JF, Raby KE, Morrow JD, Freedman JE, Lynch S, Koulouris SN, Hankin BR, Frei B. Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome. J Am Coll Cardiol. 1998 Apr; 31(5):980-6. PMID: 9561997.
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    210. Vita JA, Frei B, Holbrook M, Gokce N, Leaf C, Keaney JF. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. J Clin Invest. 1998 Mar 15; 101(6):1408-14. PMID: 9502783.
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    211. Welch GN, Upchurch GR, Farivar RS, Pigazzi A, Vu K, Brecher P, Keaney JF, Loscalzo J. Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Proc Assoc Am Physicians. 1998 Jan-Feb; 110(1):22-31. PMID: 9460080.
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    212. Mannion TC, Vita JA, Keaney JF, Benjamin EJ, Hunter L, Polak JF. Non-invasive assessment of brachial artery endothelial vasomotor function: the effect of cuff position on level of discomfort and vasomotor responses. Vasc Med. 1998; 3(4):263-7. PMID: 10102666.
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    213. Dabbagh AJ, Shwaery GT, Keaney JF, Frei B. Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2638-45. PMID: 9409237.
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    214. Lynch SM, Frei B, Morrow JD, Roberts LJ, Xu A, Jackson T, Reyna R, Klevay LM, Vita JA, Keaney JF. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2975-81. PMID: 9409284.
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    215. Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerotic heart disease. N Engl J Med. 1997 Aug 7; 337(6):408-16. PMID: 9241131.
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    216. Upchurch GR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF, Loscalzo J. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis. 1997 Jul 25; 132(2):177-85. PMID: 9242963.
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    217. Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997 Jul 15; 100(2):350-6. PMID: 9218511.
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    218. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 Jul 4; 272(27):17012-7. PMID: 9202015.
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    219. Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21. PMID: 9133522.
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    220. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiological concentrations of 17 beta-estradiol. Requirement for estradiol modification. Circulation. 1997 Mar 18; 95(6):1378-85. PMID: 9118503.
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    221. Keaney JF, Hare JM, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2646-52. PMID: 8997327.
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    222. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40. PMID: 8921785.
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    223. Jackson TS, Lerner E, Weisbrod RM, Tajima M, Loscalzo J, Keaney JF. Vasodilatory properties of recombinant maxadilan. Am J Physiol. 1996 Sep; 271(3 Pt 2):H924-30. PMID: 8853326.
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    224. Afridi N, Keaney JF. Animal studies on antioxidants. J Cardiovasc Risk. 1996 Aug; 3(4):358-62. PMID: 8946265.
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    225. Keaney JF, Guo Y, Cunningham D, Shwaery GT, Xu A, Vita JA. Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest. 1996 Jul 15; 98(2):386-94. PMID: 8755649.
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    226. Zhang YY, Xu AM, Nomen M, Walsh M, Keaney JF, Loscalzo J. Nitrosation of tryptophan residue(s) in serum albumin and model dipeptides. Biochemical characterization and bioactivity. J Biol Chem. 1996 Jun 14; 271(24):14271-9. PMID: 8662958.
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    227. Burchenal JE, Keaney JF, Curran-Celentano J, Gaziano JM, Vita JA. The lack of effect of beta-carotene on restenosis in cholesterol-fed rabbits. Atherosclerosis. 1996 Jun; 123(1-2):157-67. PMID: 8782847.
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    228. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1996 Mar 15; 93(6):1107-13. PMID: 8653830.
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    229. Frei B, Keaney JF, Retsky KL, Chen K. Vitamins C and E and LDL oxidation. Vitam Horm. 1996; 52:1-34. PMID: 8909155.
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    230. Marks DS, Vita JA, Folts JD, Keaney JF, Welch GN, Loscalzo J. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. J Clin Invest. 1995 Dec; 96(6):2630-8. PMID: 8675628.
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    231. Keaney JF, Vita JA. Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis. 1995 Sep-Oct; 38(2):129-54. PMID: 7568903.
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    232. Keaney JF, Xu A, Cunningham D, Jackson T, Frei B, Vita JA. Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. J Clin Invest. 1995 Jun; 95(6):2520-9. PMID: 7769097.
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    233. Levine GN, Keaney JF, Vita JA. Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med. 1995 Feb 23; 332(8):512-21. PMID: 7830734.
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    234. Hare JM, Keaney JF, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest. 1995 Jan; 95(1):360-6. PMID: 7529262.
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    235. Scharfstein JS, Keaney JF, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest. 1994 Oct; 94(4):1432-9. PMID: 7929818.
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    236. Keaney JF, Puyana JC, Francis S, Loscalzo JF, Stamler JS, Loscalzo J. Methylene blue reverses endotoxin-induced hypotension. Circ Res. 1994 Jun; 74(6):1121-5. PMID: 8187278.
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    237. Keaney JF, Shwaery GT, Xu A, Nicolosi RJ, Loscalzo J, Foxall TL, Vita JA. 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 1994 May; 89(5):2251-9. PMID: 8181150.
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    238. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest. 1994 Feb; 93(2):844-51. PMID: 8113416.
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    239. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11880-4. PMID: 8265642.
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    240. Simon DI, Stamler JS, Jaraki O, Keaney JF, Osborne JA, Francis SA, Singel DJ, Loscalzo J. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb. 1993 Jun; 13(6):791-9. PMID: 8388713.
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    241. Keaney JF, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest. 1993 Apr; 91(4):1582-9. PMID: 8473501.
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    242. Bittl JA, Ryan TJ, Keaney JF, Tcheng JE, Ellis SG, Isner JM, Sanborn TA. Coronary artery perforation during excimer laser coronary angioplasty. The percutaneous Excimer Laser Coronary Angioplasty Registry. J Am Coll Cardiol. 1993 Apr; 21(5):1158-65. PMID: 8459071.
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    243. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7674-7. PMID: 1502182.
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