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Andrew B Leiter MD, PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8101
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionGastroenterology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program


    Collapse Biography 
    Collapse education and training
    University of Pennsylvania, Philadelphia, PA, United StatesABBiology
    Case Western Reserve University, Cleveland, OH, United StatesMD
    Case Western Reserve University, Cleveland, OH, United StatesPHDBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Mol Metab. 2019 Nov; 29:158-169. PMID: 31668387.
      View in: PubMed
    2. Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019 Mar 04; 10(1):1029. PMID: 30833673.
      View in: PubMed
    3. Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 Feb 07. PMID: 30733330.
      View in: PubMed
    4. Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Rep. 2019 Feb 05; 26(6):1399-1408.e6. PMID: 30726726.
      View in: PubMed
    5. Knutson K, Strege PR, Li J, Leiter AB, Farrugia G, Beyder A. Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells. J Vis Exp. 2018 Sep 26; (139). PMID: 30320764.
      View in: PubMed
    6. Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, Li JH, Leiter AB, Szurszewski JH, Farrugia G, Beyder A. A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci U S A. 2018 Jul 23. PMID: 30037999.
      View in: PubMed
    7. Sei Y, Feng J, Samsel L, White AO, Zhao X, Yun S, Citrin D, McCoy JP, Sundaresan S, Hayes MM, Merchant JL, Leiter AB, Wank SA. Mature Enteroendocrine Cells Contributes to Basal and Pathological Stem Cell Dynamics in the Small Intestine. Am J Physiol Gastrointest Liver Physiol. 2018 May 31. PMID: 29848020.
      View in: PubMed
    8. Strege PR, Knutson K, Eggers SJ, Li JH, Wang F, Linden D, Szurszewski JH, Milescu L, Leiter AB, Farrugia G, Beyder A. Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. Sci Rep. 2017 Nov 15; 7(1):15650. PMID: 29142310.
      View in: PubMed
    9. Ray SK, Li HJ, Leiter AB. Oligomeric form of C-terminal-binding protein coactivates NeuroD1-mediated transcription. FEBS Lett. 2017 Jan; 591(1):205-212. PMID: 27880001.
      View in: PubMed
    10. Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, Leiter AB, Farrugia G, Beyder A. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017 Jan 01; 595(1):79-91. PMID: 27392819.
      View in: PubMed
    11. Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY. The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1. PLoS One. 2015; 10(6):e0128035. PMID: 26030886.
      View in: PubMed
    12. Ray SK, Li HJ, Metzger E, Schüle R, Leiter AB. CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells. Mol Cell Biol. 2014 Jun; 34(12):2308-17. PMID: 24732800.
      View in: PubMed
    13. Li HJ, Johnston B, Aiello D, Caffrey DR, Giel-Moloney M, Rindi G, Leiter AB. Distinct cellular origins for serotonin-expressing and enterochromaffin-like cells in the gastric corpus. Gastroenterology. 2014 Mar; 146(3):754-764.e3. PMID: 24316261.
      View in: PubMed
    14. Li HJ, Kapoor A, Giel-Moloney M, Rindi G, Leiter AB. Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15; 371(2):156-69. PMID: 22964416.
      View in: PubMed
    15. Gelegen C, Chandarana K, Choudhury AI, Al-Qassab H, Evans IM, Irvine EE, Hyde CB, Claret M, Andreelli F, Sloan SE, Leiter AB, Withers DJ, Batterham RL. Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice. Am J Physiol Endocrinol Metab. 2012 Sep 1; 303(5):E659-68. PMID: 22761162.
      View in: PubMed
    16. Packard A, Giel-Moloney M, Leiter A, Schwob JE. Progenitor cell capacity of NeuroD1-expressing globose basal cells in the mouse olfactory epithelium. J Comp Neurol. 2011 Dec 1; 519(17):3580-96. PMID: 21800309.
      View in: PubMed
    17. Li HJ, Ray SK, Singh NK, Johnston B, Leiter AB. Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation. Diabetes Obes Metab. 2011 Oct; 13 Suppl 1:5-12. PMID: 21824251.
      View in: PubMed
    18. Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL. Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Dev Biol. 2011 Jan 15; 349(2):406-16. PMID: 21074524.
      View in: PubMed
    19. Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene. 2010 Jan 14; 29(2):285-96. PMID: 19855437.
      View in: PubMed
    20. Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW, Defuria J, Singru PS, Lechan RM, Huber BT. Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity. Endocrinology. 2009 Dec; 150(12):5240-8. PMID: 19819973.
      View in: PubMed
    21. Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec; 126(11-12):958-73. PMID: 19766716.
      View in: PubMed
    22. Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB, Shivdasani RA. Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18. PMID: 18347062.
      View in: PubMed
    23. Fujiki Y, Tao K, Bianchi DW, Giel-Moloney M, Leiter AB, Johnson KL. Quantification of green fluorescent protein by in vivo imaging, PCR, and flow cytometry: comparison of transgenic strains and relevance for fetal cell microchimerism. Cytometry A. 2008 Feb; 73(2):11-118. PMID: 18205194.
      View in: PubMed
    24. Ray SK, Leiter AB. The basic helix-loop-helix transcription factor NeuroD1 facilitates interaction of Sp1 with the secretin gene enhancer. Mol Cell Biol. 2007 Nov; 27(22):7839-47. PMID: 17875929.
      View in: PubMed
    25. Wang Y, Ray SK, Hinds PW, Leiter AB. The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression. Dev Biol. 2007 Nov 15; 311(2):478-86. PMID: 17936268.
      View in: PubMed
    26. Kapoor A, Li HJ, Leiter AB. Intestinal development: the many faces of Wnt signaling. Gastroenterology. 2007 Aug; 133(2):710-2. PMID: 17681188.
      View in: PubMed
    27. Wang Y, Giel-Moloney M, Rindi G, Leiter AB. Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11328-33. PMID: 17592150.
      View in: PubMed
    28. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70. PMID: 17550981.
      View in: PubMed
    29. Giel-Moloney M, Krause DS, Chen G, Van Etten RA, Leiter AB. Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice. Genesis. 2007 Feb; 45(2):83-9. PMID: 17269129.
      View in: PubMed
    30. Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F. NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor. Dev Dyn. 2005 Jul; 233(3):946-53. PMID: 15906379.
      View in: PubMed
    31. Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol. 2005 May; 25(10):4189-99. PMID: 15870288.
      View in: PubMed
    32. Lossi L, Bottarelli L, Candusso ME, Leiter AB, Rindi G, Merighi A. Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci. 2004 Dec; 20(12):3259-69. PMID: 15610158.
      View in: PubMed
    33. Rindi G, Civallero M, Candusso ME, Marchetti A, Klersy C, Nano R, Leiter AB. Sudden onset of colitis after ablation of secretin-expressing lymphocytes in transgenic mice. Exp Biol Med (Maywood). 2004 Sep; 229(8):826-34. PMID: 15337838.
      View in: PubMed
    34. Adams SH, Won WB, Schonhoff SE, Leiter AB, Paterniti JR. Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology. 2004 Nov; 145(11):4967-75. PMID: 15284202.
      View in: PubMed
    35. Schonhoff SE, Giel-Moloney M, Leiter AB. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol. 2004 Jun 15; 270(2):443-54. PMID: 15183725.
      View in: PubMed
    36. Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The "normal" endocrine cell of the gut: changing concepts and new evidences. Ann N Y Acad Sci. 2004 Apr; 1014:1-12. PMID: 15153415.
      View in: PubMed
    37. Schonhoff SE, Giel-Moloney M, Leiter AB. Minireview: Development and differentiation of gut endocrine cells. Endocrinology. 2004 Jun; 145(6):2639-44. PMID: 15044355.
      View in: PubMed
    38. Wang G, Leiter AB, Englander EW, Greeley GH. Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites. Endocrinology. 2004 Feb; 145(2):659-66. PMID: 14592960.
      View in: PubMed
    39. Cotta-de-Almeida V, Schonhoff S, Shibata T, Leiter A, Snapper SB. A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res. 2003 Sep; 13(9):2190-4. PMID: 12915491.
      View in: PubMed
    40. Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol. 2003 Jan; 23(1):259-71. PMID: 12482979.
      View in: PubMed
    41. Laforenza U, Gastaldi G, Rindi G, Leiter AB, Cova E, Marchetti A, Candusso ME, Autelli M, Orsenigo MN, Ventura U. PYY-Tag transgenic mice displaying abnormal (H+-K+)ATPase activity and gastric mucosal barrier impairment. Lab Invest. 2003 Jan; 83(1):47-54. PMID: 12533685.
      View in: PubMed
    42. Ratineau C, Petry MW, Mutoh H, Leiter AB. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem. 2002 Mar 15; 277(11):8847-53. PMID: 11788592.
      View in: PubMed
    43. Shih HH, Xiu M, Berasi SP, Sampson EM, Leiter A, Paulson KE, Yee AS. HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue. Mol Cell Biol. 2001 Sep; 21(17):5723-32. PMID: 11486012.
      View in: PubMed
    44. Ratineau C, Ronco A, Leiter AB. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Gastroenterology. 2000 Nov; 119(5):1305-11. PMID: 11054388.
      View in: PubMed
    45. Mutoh H, Ratineau C, Ray S, Leiter AB. Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells. Aliment Pharmacol Ther. 2000 Apr; 14 Suppl 1:170-5. PMID: 10807420.
      View in: PubMed
    46. Rindi G, Ratineau C, Ronco A, Candusso ME, Tsai M, Leiter AB. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Development. 1999 Sep; 126(18):4149-56. PMID: 10457023.
      View in: PubMed
    47. Mutoh H, Naya FJ, Tsai MJ, Leiter AB. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15; 12(6):820-30. PMID: 9512516.
      View in: PubMed
    48. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997 Sep 15; 11(18):2323-34. PMID: 9308961.
      View in: PubMed
    49. Mutoh H, Fung BP, Naya FJ, Tsai MJ, Nishitani J, Leiter AB. The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3560-4. PMID: 9108015.
      View in: PubMed
    50. Upchurch BH, Fung BP, Rindi G, Ronco A, Leiter AB. Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice. Development. 1996 Apr; 122(4):1157-63. PMID: 8620842.
      View in: PubMed
    51. Lopez MJ, Upchurch BH, Rindi G, Leiter AB. Studies in transgenic mice reveal potential relationships between secretin-producing cells and other endocrine cell types. J Biol Chem. 1995 Jan 13; 270(2):885-91. PMID: 7822327.
      View in: PubMed
    52. Nishitani J, Rindi G, Lopez MJ, Upchurch BH, Leiter AB. Transcriptional regulation of secretin gene expression. J Clin Gastroenterol. 1995; 21 Suppl 1:S50-55. PMID: 8774991.
      View in: PubMed
    53. Chang CH, Chey WY, Sun Q, Leiter A, Chang TM. Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1. Biochim Biophys Acta. 1994 Apr 28; 1221(3):339-47. PMID: 8167157.
      View in: PubMed
    54. Upchurch BH, Aponte GW, Leiter AB. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb; 120(2):245-52. PMID: 8149907.
      View in: PubMed
    55. Wheeler MB, Nishitani J, Buchan AM, Kopin AS, Chey WY, Chang TM, Leiter AB. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene. Mol Cell Biol. 1992 Aug; 12(8):3531-9. PMID: 1378528.
      View in: PubMed
    56. Kopin AS, Wheeler MB, Nishitani J, McBride EW, Chang TM, Chey WY, Leiter AB. The secretin gene: evolutionary history, alternative splicing, and developmental regulation. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5335-9. PMID: 1711228.
      View in: PubMed
    57. Krasinski SD, Wheeler MB, Leiter AB. Isolation, characterization, and developmental expression of the rat peptide-YY gene. Mol Endocrinol. 1991 Mar; 5(3):433-40. PMID: 1890992.
      View in: PubMed
    58. Kopin AS, Wheeler MB, Leiter AB. Secretin: structure of the precursor and tissue distribution of the mRNA. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2299-303. PMID: 2315322.
      View in: PubMed
    59. Krasinski SD, Wheeler MB, Kopin AS, Leiter AB. Pancreatic polypeptide and peptide YY gene expression. Ann N Y Acad Sci. 1990; 611:73-85. PMID: 2248485.
      View in: PubMed
    60. Kopin AS, Toder AE, Leiter AB. Different splice site utilization generates diversity between the rat and human pancreatic polypeptide precursors. Arch Biochem Biophys. 1988 Dec; 267(2):742-8. PMID: 3214179.
      View in: PubMed
    61. Leiter AB, Toder A, Wolfe HJ, Taylor IL, Cooperman S, Mandel G, Goodman RH. Peptide YY. Structure of the precursor and expression in exocrine pancreas. J Biol Chem. 1987 Sep 25; 262(27):12984-8. PMID: 3654598.
      View in: PubMed
    62. Goodman RH, Leiter A, Low MJ, Montminy MR, Tsukada T, Fink JS, Mandel G. Biosynthesis of pancreatic islet hormones. Hepatology. 1987 Jan-Feb; 7(1 Suppl):36S-41S. PMID: 2879784.
      View in: PubMed
    63. Leiter AB, Montminy MR, Jamieson E, Goodman RH. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. J Biol Chem. 1985 Oct 25; 260(24):13013-7. PMID: 2997153.
      View in: PubMed
    64. Leiter AB, Keutmann HT, Goodman RH. Structure of a precursor to human pancreatic polypeptide. J Biol Chem. 1984 Dec 10; 259(23):14702-5. PMID: 6094571.
      View in: PubMed
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