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Jason K Kim PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
368 Plantation Street, Sherman Center, AS9.1041
Worcester MA 01605
Phone508-856-6807
Email
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionEndocrinology & Metabolism

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


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    Collapse Biography 
    Collapse education and training
    University of California, Irvine, Irvine, CA, United StatesBSBiological Sciences
    University of Southern California, Los Angeles, CA, United StatesPHDPhysiology & Biophysics
    Yale University School of Medicine, New Haven, CTPost-doc1999Endocrinology & Metabolism
    Yale University School of Medicine, New Haven, CTAssistant Professor2002Endocrinology & Metabolism
    Penn State College of Medicine, Hershey, PAAssociate Professor2005Cellular & Molecular Physiology
    UMass Medical School, Worcester, MAProfessor2008Molecular Medicine

    Collapse Overview 
    Collapse overview

    Investigating the Molecular Link Between Obesity, Inflammation, and Type 2 Diabetes


    Our research focuses on obesity, insulin resistance, and type 2 diabetes. For more than 25 years, we have made a significant contribution to the field with 143 peer-reviewed publications, mostly in high-impact scientific journals. Obesity is a major cause of type 2 diabetes, and together they impact more than 500 million people worldwide. Obesity is characterized by insulin resistance in which insulin’s ability to regulate glucose metabolism is impaired, and insulin resistance is an important early event in the development of type 2 diabetes. The goal of our NIH-funded research program is to investigate the molecular link between obesity, inflammation, and type 2 diabetes. Our current projects focus on the role of obesity-mediated inflammation in insulin resistance, and this is largely based on our earlier findings that macrophages and inflammatory cytokines regulate glucose metabolism in skeletal muscle and liver. Using novel genetic mouse models of altered macrophage function and cytokine signaling developed by our laboratory and elegant metabolic procedures, we investigate the underlying mechanism by which obesity-mediated inflammation causes insulin resistance and type 2 diabetes. Other projects focus on the therapeutic potential of anti-inflammatory cytokine as well as endoplasmic reticulum stress regulators in the treatment of insulin resistance.


    Heart failure is a leading cause of mortality in type 2 diabetes, but the underlying mechanism by which diabetes increases cardiovascular events is presently unknown. Diabetic heart is characterized by altered metabolism and insulin resistance that may be causally associated with functional and pathological abnormalities. Our current projects utilize experimental mouse models of obesity (e.g., chronic high-fat diet feeding) as well as genetic mouse models of altered myocardial ER stress to determine the molecular mechanism of diabetic heart disease.


    Collaboration Projects: Our research program has always fostered collaborative research. One collaborative research with a leading cancer biologist on campus examines a potential link between diabetes and cancer using genetic mouse models of breast cancer coupled to our sophisticated experimental approaches to assess energy balance and metabolism. Another collaborative research with a leading microbiome program at NYU examines a novel role of intestinal microflora in obesity and insulin resistance.


    National Mouse Metabolic Phenotyping Center


    The National Mouse Metabolic Phenotyping Center (MMPC) Consortium (www.mmpc.org) was established by the National Institutes of Health in 2001 to provide innovative and unique scientific approaches to the global research community. Currently, we are one of five National MMPCs awarded by the NIH to serve on this consortium with other Centers located at the Vanderbilt University, UC Davis, University of Michigan, and University of Cincinnati. The National MMPC at UMass is designed to provide an array of sophisticated and elegant research techniques to the scientific community for the purpose of investigating mouse models of human disease. Our goal is to advance medical and biological research by offering comprehensive, standardized, and high quality metabolic phenotyping tools for mouse models of obesity, diabetes, and its complications. Our Center is composed of multidisciplinary group of investigators and leading scientists with state-of-the-art technologies at the UMass Medical School. The National MMPC at UMass consists of the following Phenotyping Cores: 1) Metabolism Core performs elegant, physiological, and mostly non-invasive metabolic procedures to measure insulin sensitivity and glucose/lipid/protein metabolism, body composition, energy balance at varying temperature and light/dark cycle, and exercise effects in mice. 2) Analytical Core utilizes Luminex and Cobas Clinical Chemistry Analyzer for high-throughput and multiplexed analyses of serum/tissue levels of hormones, cytokines/chemokines, and metabolites. 3) Islet Core conducts sophisticated in vivo, ex vivo, and in vitro analyses of pancreatic function and insulin secretion in mice. 4) Cardiovascular Core applies high-frequency and high-resolution digital imaging platform with color Doppler mode to conduct echocardiography for non-invasive assessment of cardiovascular function and structure, blood pressure, and endothelial function as well as elegant micro-surgery to generate mouse models of CVD, PVD, and aneurysm to investigate diabetic complications.


    Our overall mission is to find a cure for type 2 diabetes.


    We are located at the 9th floor of the Albert Sherman Center, and if you are interested in visiting our research program, please contact our administrative assistant, Ms. Theresa Kane at (508) 856-6840 or theresa.kane@umassmed.edu.



    Collapse Rotation Projects

    Lab rotations are currently available in this lab. Please contact Dr. Kim.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 May 28. PMID: 28556482.
      View in: PubMed
    2. Dagdeviren S, Jung DY, Lee E, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N, Tsitsilianos AV, Tran DA, Tsougranis GH, Kearns CC, Uong CP, Kwon JY, Muller W, Lee KW, Kim JK. Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance. Mol Cell Biol. 2016 Dec 01; 36(23):2956-2966. PMID: 27644327.
      View in: PubMed
    3. Dagdeviren S, Jung DY, Friedline RH, Noh HL, Kim JH, Patel PR, Tsitsilianos N, Inashima K, Tran DA, Hu X, Loubato MM, Craige SM, Kwon JY, Lee KW, Kim JK. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle. FASEB J. 2017 Feb; 31(2):701-710. PMID: 27811060.
      View in: PubMed
    4. Li Z, Frey JL, Wong GW, Faugere MC, Wolfgang MJ, Kim JK, Riddle RC, Clemens TL. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology. 2016 Nov; 157(11):4094-4103. PMID: 27689415.
      View in: PubMed
    5. DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP. Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance. Mol Metab. 2016 Dec; 5(12):1149-1161. PMID: 27900258.
      View in: PubMed
    6. Kim MS, Krawczyk SA, Doridot L, Fowler AJ, Wang JX, Trauger SA, Noh HL, Kang HJ, Meissen JK, Blatnik M, Kim JK, Lai M, Herman MA. ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest. 2016 Nov 01; 126(11):4372-4386. PMID: 27669460.
      View in: PubMed
    7. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. An alternative splicing program promotes adipose tissue thermogenesis. Elife. 2016 Sep 16; 5. PMID: 27635635.
      View in: PubMed
    8. Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem. 2016 Jul 29; 291(31):16221-30. PMID: 27226575.
      View in: PubMed
    9. Jara A, Liu X, Sim D, Benner CM, Duran-Ortiz S, Qian Y, List EO, Berryman DE, Kim JK, Kopchick JJ. Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice. Endocrinology. 2016 May; 157(5):1929-41. PMID: 27035649.
      View in: PubMed
    10. Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016 Apr 1; 126(4):1401-12. PMID: 26974159.
      View in: PubMed
    11. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
      View in: PubMed
    12. Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP. Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. Nat Commun. 2016 Feb 16; 7:10686. PMID: 26880110.
      View in: PubMed
    13. Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C. Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. Diabetes. 2016 Apr; 65(4):902-12. PMID: 26858359.
      View in: PubMed
    14. Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016 Mar; 22(3):312-8. PMID: 26808348.
      View in: PubMed
    15. Friedline RH, Ko HJ, Jung DY, Lee Y, Bortell R, Dagdeviren S, Patel PR, Hu X, Inashima K, Kearns C, Tsitsilianos N, Shafiq U, Shultz LD, Lee KW, Greiner DL, Kim JK. Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance. FASEB J. 2016 Mar; 30(3):1328-38. PMID: 26644351.
      View in: PubMed
    16. Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM. Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). J Biol Chem. 2016 Jan 08; 291(2):980-8. PMID: 26586918.
      View in: PubMed
    17. Danai LV, Flach RJ, Virbasius JV, Menendez LG, Jung DY, Kim JH, Kim JK, Czech MP. Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues. Mol Cell Biol. 2015 Jul; 35(13):2356-65. PMID: 25918248.
      View in: PubMed
    18. Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM. Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. Diabetes. 2015 Aug; 64(8):2780-90. PMID: 25972571.
      View in: PubMed
    19. Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP. A major role of insulin in promoting obesity-associated adipose tissue inflammation. Mol Metab. 2015 Jul; 4(7):507-18. PMID: 26137438.
      View in: PubMed
    20. Lee E, Jung DY, Kim JH, Patel PR, Hu X, Lee Y, Azuma Y, Wang HF, Tsitsilianos N, Shafiq U, Kwon JY, Lee HJ, Lee KW, Kim JK. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB J. 2015 Aug; 29(8):3182-92. PMID: 25888600.
      View in: PubMed
    21. Johnson E, Chase K, McGowan S, Mondo E, Pfister E, Mick E, Friedline RH, Kim JK, Sapp E, DiFiglia M, Aronin N. Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model. J Huntingtons Dis. 2015; 4(3):219-29. PMID: 26444021.
      View in: PubMed
    22. Armata HL, Chamberland S, Watts L, Ko HJ, Lee Y, Jung DY, Kim JK, Sluss HK. Deficiency of the tumor promoter gene wip1 induces insulin resistance. Mol Endocrinol. 2015 Jan; 29(1):28-39. PMID: 25379953.
      View in: PubMed
    23. Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PLoS One. 2014; 9(9):e107265. PMID: 25216251.
      View in: PubMed
    24. Pan D, Mao C, Quattrochi B, Friedline RH, Zhu LJ, Jung DY, Kim JK, Lewis B, Wang YX. MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun. 2014 Aug 22; 5:4725. PMID: 25145289.
      View in: PubMed
    25. Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. The PPARa-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metab. 2014 Sep 2; 20(3):512-25. PMID: 25043817.
      View in: PubMed
    26. Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug; 124(8):3339-51. PMID: 24983316.
      View in: PubMed
    27. Song F, Hurtado del Pozo C, Rosario R, Zou YS, Ananthakrishnan R, Xu X, Patel PR, Benoit VM, Yan SF, Li H, Friedman RA, Kim JK, Ramasamy R, Ferrante AW, Schmidt AM. RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice. Diabetes. 2014 Jun; 63(6):1948-65. PMID: 24520121.
      View in: PubMed
    28. Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev. 2013 Nov 1; 27(21):2345-55. PMID: 24186979.
      View in: PubMed
    29. Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S. KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One. 2013; 8(10):e77851. PMID: 24167585.
      View in: PubMed
    30. Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Rep. 2013 Aug 29; 4(4):681-8. PMID: 23954791.
      View in: PubMed
    31. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374.
      View in: PubMed
    32. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
      View in: PubMed
    33. Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013 May; 19(5):640-5. PMID: 23563706.
      View in: PubMed
    34. Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013 May 1; 304(9):E951-63. PMID: 23482447.
      View in: PubMed
    35. Jung DY, Ko HJ, Lichtman EI, Lee E, Lawton E, Ong H, Yu K, Azuma Y, Friedline RH, Lee KW, Kim JK. Short-term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice. Am J Physiol Endocrinol Metab. 2013 May 1; 304(9):E964-76. PMID: 23482446.
      View in: PubMed
    36. Chen SJ, Zhang W, Tong Q, Conrad K, Hirschler-Laszkiewicz I, Bayerl M, Kim JK, Cheung JY, Miller BA. Role of TRPM2 in cell proliferation and susceptibility to oxidative stress. Am J Physiol Cell Physiol. 2013 Mar; 304(6):C548-60. PMID: 23302782.
      View in: PubMed
    37. Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11; 339(6116):218-22. PMID: 23223452.
      View in: PubMed
    38. Zhu G, Ye R, Jung DY, Barron E, Friedline RH, Benoit VM, Hinton DR, Kim JK, Lee AS. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013 Mar; 27(3):955-64. PMID: 23180827.
      View in: PubMed
    39. Franck D, Tracy L, Armata HL, Delaney CL, Jung DY, Ko HJ, Ong H, Kim JK, Scrable H, Sluss HK. Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain. Endocr Res. 2012 Oct 26. PMID: 23102272.
      View in: PubMed
    40. Sumara G, Sumara O, Kim JK, Karsenty G. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab. 2012 Nov 7; 16(5):588-600. PMID: 23085101.
      View in: PubMed
    41. Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69. PMID: 22619361.
      View in: PubMed
    42. Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012 Mar 04; 9(4):403-9. PMID: 22388288.
      View in: PubMed
    43. González-Rodríguez A, Más-Gutierrez JA, Mirasierra M, Fernandez-Pérez A, Lee YJ, Ko HJ, Kim JK, Romanos E, Carrascosa JM, Ros M, Vallejo M, Rondinone CM, Valverde AM. Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell. 2012 Apr; 11(2):284-96. PMID: 22221695.
      View in: PubMed
    44. Kim JK. Endothelial nuclear factor ?B in obesity and aging: is endothelial nuclear factor ?B a master regulator of inflammation and insulin resistance? Circulation. 2012 Mar 6; 125(9):1081-3. PMID: 22302839.
      View in: PubMed
    45. Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr 1; 302(7):E807-16. PMID: 22275755.
      View in: PubMed
    46. Alexandrov IM, Ivshina M, Jung DY, Friedline R, Ko HJ, Xu M, O'Sullivan-Murphy B, Bortell R, Huang YT, Urano F, Kim JK, Richter JD. Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet. 2012 Jan; 8(1):e1002457. PMID: 22253608.
      View in: PubMed
    47. Chan CB, Liu X, He K, Qi Q, Jung DY, Kim JK, Ye K. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep. 2011 Jul 01; 12(8):847-54. PMID: 21720388.
      View in: PubMed
    48. Gray S, Kim JK. New insights into insulin resistance in the diabetic heart. Trends Endocrinol Metab. 2011 Oct; 22(10):394-403. PMID: 21680199.
      View in: PubMed
    49. Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes. 2011 Feb; 60(2):669-79. PMID: 21270276.
      View in: PubMed
    50. Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res. 2011 Mar; 52(3):509-17. PMID: 21068007.
      View in: PubMed
    51. Armata HL, Golebiowski D, Jung DY, Ko HJ, Kim JK, Sluss HK. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol. 2010 Dec; 30(24):5787-94. PMID: 20956556.
      View in: PubMed
    52. Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Mol Cell Biol. 2010 Oct; 30(19):4616-25. PMID: 20679483.
      View in: PubMed
    53. Lee SJ, Kim JY, Nogueiras R, Linares JF, Perez-Tilve D, Jung DY, Ko HJ, Hofmann SM, Drew A, Leitges M, Kim JK, Tschöp MH, Diaz-Meco MT, Moscat J. PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab. 2010 Jul 7; 12(1):65-77. PMID: 20620996.
      View in: PubMed
    54. Kim JK. Inflammation and insulin resistance: an old story with new ideas. Korean Diabetes J. 2010 Jun; 34(3):137-45. PMID: 20617073.
      View in: PubMed
    55. Yew NS, Zhao H, Hong EG, Wu IH, Przybylska M, Siegel C, Shayman JA, Arbeeny CM, Kim JK, Jiang C, Cheng SH. Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase. PLoS One. 2010 Jun 21; 5(6):e11239. PMID: 20574539.
      View in: PubMed
    56. Davis RC, Castellani LW, Hosseini M, Ben-Zeev O, Mao HZ, Weinstein MM, Jung DY, Jun JY, Kim JK, Lusis AJ, Péterfy M. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes. 2010 Jul; 59(7):1616-25. PMID: 20393148.
      View in: PubMed
    57. Heinrich G, Ghosh S, Deangelis AM, Schroeder-Gloeckler JM, Patel PR, Castaneda TR, Jeffers S, Lee AD, Jung DY, Zhang Z, Opland DM, Myers MG, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice. Gastroenterology. 2010 Aug; 139(2):644-52, 652.e1. PMID: 20381490.
      View in: PubMed
    58. Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 2010 Feb 1; 24(3):256-64. PMID: 20080940.
      View in: PubMed
    59. Chan CB, Liu X, Jung DY, Jun JY, Luo HR, Kim JK, Ye K. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes. 2010 Apr; 59(4):883-93. PMID: 20068140.
      View in: PubMed
    60. Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol. 2010 Jan; 30(1):106-15. PMID: 19841069.
      View in: PubMed
    61. Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan M, Gao Z, Ye J. Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem. 2010 Feb 12; 285(7):4637-44. PMID: 20018865.
      View in: PubMed
    62. Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest. 2010 Jan; 120(1):357-68. PMID: 20038793.
      View in: PubMed
    63. Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab. 2009 Dec; 10(6):491-8. PMID: 19945406.
      View in: PubMed
    64. Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab. 2009 Nov; 10(5):366-78. PMID: 19883615.
      View in: PubMed
    65. Ye R, Jung DY, Jun JY, Li J, Luo S, Ko HJ, Kim JK, Lee AS. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes. 2010 Jan; 59(1):6-16. PMID: 19808896.
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    66. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Kajimura D, Myers MG, Chua SC, Wang Q, Kim JK, Kaestner KH, Karsenty G. An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci. 2009 Sep; 1173 Suppl 1:E20-30. PMID: 19751411.
      View in: PubMed
    67. Ko HJ, Zhang Z, Jung DY, Jun JY, Ma Z, Jones KE, Chan SY, Kim JK. Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes. 2009 Nov; 58(11):2536-46. PMID: 19690060.
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    68. Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, Friedline RH, Kurt-Jones E, Finberg R, Fischer MA, Granger EL, Norbury CC, Hauschka SD, Philbrick WM, Lee CG, Elias JA, Kim JK. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes. 2009 Nov; 58(11):2525-35. PMID: 19690064.
      View in: PubMed
    69. Yoshizawa T, Hinoi E, Jung DY, Kajimura D, Ferron M, Seo J, Graff JM, Kim JK, Karsenty G. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest. 2009 Sep; 119(9):2807-17. PMID: 19726872.
      View in: PubMed
    70. Sung HK, Sung HK, Kim YW, Choi SJ, Kim JY, Jeune KH, Won KC, Kim JK, Koh GY, Koh GY, Park SY. COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E402-9. PMID: 19491299.
      View in: PubMed
    71. Kim JK. Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity in vivo. Methods Mol Biol. 2009; 560:221-38. PMID: 19504253.
      View in: PubMed
    72. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Chua SC, Kim JK, Kaestner KH, Karsenty G. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol. 2008 Dec 29; 183(7):1235-42. PMID: 19103808.
      View in: PubMed
    73. Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes. 2009 Mar; 58(3):590-9. PMID: 19074988.
      View in: PubMed
    74. Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science. 2008 Dec 5; 322(5907):1539-43. PMID: 19056984.
      View in: PubMed
    75. Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA. The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci. 2008 Nov 26; 28(48):12946-55. PMID: 19036988.
      View in: PubMed
    76. Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes. 2009 Jan; 58(1):116-24. PMID: 18952837.
      View in: PubMed
    77. Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009 Jan; 58(1):250-9. PMID: 18840786.
      View in: PubMed
    78. DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008 Sep; 57(9):2296-303. PMID: 18544705.
      View in: PubMed
    79. Hui ST, Andres AM, Miller AK, Spann NJ, Potter DW, Post NM, Chen AZ, Sachithanantham S, Jung DY, Kim JK, Davis RA. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3921-6. PMID: 18322014.
      View in: PubMed
    80. Lee S, Muniyappa R, Yan X, Chen H, Yue LQ, Hong EG, Kim JK, Quon MJ. Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E261-70. PMID: 18003716.
      View in: PubMed
    81. Atsumi T, Cho YR, Leng L, McDonald C, Yu T, Danton C, Hong EG, Mitchell RA, Metz C, Niwa H, Takeuchi J, Onodera S, Umino T, Yoshioka N, Koike T, Kim JK, Bucala R. The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. J Immunol. 2007 Oct 15; 179(8):5399-406. PMID: 17911626.
      View in: PubMed
    82. Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1687-96. PMID: 17911348.
      View in: PubMed
    83. Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007 Nov; 27(21):7727-34. PMID: 17724080.
      View in: PubMed
    84. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 Aug 10; 130(3):456-69. PMID: 17693256.
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    85. Cho YR, Kim HJ, Park SY, Ko HJ, Hong EG, Higashimori T, Zhang Z, Jung DY, Ola MS, Lanoue KF, Leiter EH, Kim JK. Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E327-36. PMID: 17616608.
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    86. Choi CS, Fillmore JJ, Kim JK, Liu ZX, Kim S, Collier EF, Kulkarni A, Distefano A, Hwang YJ, Kahn M, Chen Y, Yu C, Moore IK, Reznick RM, Higashimori T, Shulman GI. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest. 2007 Jul; 117(7):1995-2003. PMID: 17571165.
      View in: PubMed
    87. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374.
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    88. Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5680-5. PMID: 17372192.
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    89. Kim JK. Fat uses a TOLL-road to connect inflammation and diabetes. Cell Metab. 2006 Dec; 4(6):417-9. PMID: 17141623.
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    90. Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 2006 Jul; 55(7):1915-22. PMID: 16804058.
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    91. Wu JJ, Roth RJ, Anderson EJ, Hong EG, Lee MK, Choi CS, Neufer PD, Shulman GI, Kim JK, Bennett AM. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab. 2006 Jul; 4(1):61-73. PMID: 16814733.
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    92. Park SY, Cho YR, Kim HJ, Hong EG, Higashimori T, Lee SJ, Goldberg IJ, Shulman GI, Najjar SM, Kim JK. Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E517-24. PMID: 16638824.
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    93. Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med. 2006 May; 12(5):549-56. PMID: 16617349.
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    94. Matsui T, Nagoshi T, Hong EG, Luptak I, Hartil K, Li L, Gorovits N, Charron MJ, Kim JK, Tian R, Rosenzweig A. Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E789-97. PMID: 16352665.
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    95. Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, Dey A, Rothermel B, Kim YB, Kalinowski A, Russell KS, Kim JK. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes. 2005 Dec; 54(12):3530-40. PMID: 16306372.
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    96. Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 2005 Sep; 54(9):2514-24. PMID: 16123338.
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    97. Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug; 2(2):119-29. PMID: 16098829.
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    98. Kim JK, Kim HJ, Park SY, Cederberg A, Westergren R, Nilsson D, Higashimori T, Cho YR, Liu ZX, Dong J, Cline GW, Enerback S, Shulman GI. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes. 2005 Jun; 54(6):1657-63. PMID: 15919786.
      View in: PubMed
    99. Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am J Physiol Endocrinol Metab. 2005 Jul; 289(1):E30-9. PMID: 15701680.
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    100. Capozza F, Combs TP, Cohen AW, Cho YR, Park SY, Schubert W, Williams TM, Brasaemle DL, Jelicks LA, Scherer PE, Kim JK, Lisanti MP. Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1317-31. PMID: 15689413.
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    101. Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI. PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest. 2004 Sep; 114(6):823-7. PMID: 15372106.
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    102. Spurlin BA, Park SY, Nevins AK, Kim JK, Thurmond DC. Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle. Diabetes. 2004 Sep; 53(9):2223-31. PMID: 15331531.
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    103. Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ. Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res. 2004 Aug; 14(4):309-18. PMID: 15231300.
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    104. Tsai YS, Kim HJ, Takahashi N, Kim HS, Hagaman JR, Kim JK, Maeda N. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest. 2004 Jul; 114(2):240-9. PMID: 15254591.
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    105. Erol E, Cline GW, Kim JK, Taegtmeyer H, Binas B. Nonacute effects of H-FABP deficiency on skeletal muscle glucose uptake in vitro. Am J Physiol Endocrinol Metab. 2004 Nov; 287(5):E977-82. PMID: 15198933.
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    106. Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, Kim JK. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes. 2004 Apr; 53(4):1060-7. PMID: 15047622.
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    107. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004 Jun 4; 279(23):24844-51. PMID: 15031294.
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    108. Augustus A, Yagyu H, Haemmerle G, Bensadoun A, Vikramadithyan RK, Park SY, Kim JK, Zechner R, Goldberg IJ. Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem. 2004 Jun 11; 279(24):25050-7. PMID: 15028738.
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    109. Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, Punreddy S, Mozell RL, Tan G, Stricker-Krongrad A, Hirsch DJ, Fillmore JJ, Liu ZX, Dong J, Cline G, Stahl A, Lodish HF, Shulman GI. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest. 2004 Mar; 113(5):756-63. PMID: 14991074.
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    110. Rangwala SM, Rhoades B, Shapiro JS, Rich AS, Kim JK, Shulman GI, Kaestner KH, Lazar MA. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell. 2003 Oct; 5(4):657-63. PMID: 14536066.
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    111. Spurlin BA, Thomas RM, Nevins AK, Kim HJ, Kim YJ, Noh HL, Shulman GI, Kim JK, Thurmond DC. Insulin resistance in tetracycline-repressible Munc18c transgenic mice. Diabetes. 2003 Aug; 52(8):1910-7. PMID: 12882905.
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    112. Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes. 2003 Jun; 52(6):1311-8. PMID: 12765938.
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    113. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002 Dec 27; 277(52):50230-6. PMID: 12006582.
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    114. Haluzik M, Dietz KR, Kim JK, Marcus-Samuels B, Shulman GI, Gavrilova O, Reitman ML. Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes. 2002 Jul; 51(7):2113-8. PMID: 12086940.
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