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Liisa K Selin MD, PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionBasic Pathology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    Collapse Biography 
    Collapse education and training
    Dalhousie University, Halifax, NS, CanadaBSBiology & Psychology
    Dalhousie University, Halifax, NS, CanadaMD
    University of Manitoba, Winnipeg, MB, CanadaPHDMedical Microbiology

    Collapse Overview 
    Collapse overview

    Academic Background

    Dr. Liisa K. Selin received her B.Sc. degree (Biology and Psychology) in 1974 and M.D. degree in 1979, both from Dalhousie University, Halifax, Nova Scotia. She is Board Certified in Internal Medicine (1984, in Canada ), with fellowship training in infectious diseases. She also completed her PhD training in microbiology and immunology at the University of Manitoba, Winnipeg, Manitoba (Canada) in 1993 followed by 2 years of postdoctoral training at the University of Massachusetts Medical School, Worcester, MA. She joined the faculty in the Dept. of Pathology at the University of Massachusetts Medical School as an Instructor in 1994 and was promoted to her present position as Associate Professor in 2001. Dr. Selin has studied the role of T cells in response to viral infections; specifically, initially identifying and focusing on the phenomenon of heterologous immunity, whereby memory T cell responses to pathogens can influence the outcome to subsequent infection with unrelated pathogens. The effects of heterologous immunity are now known, at least in part, to be mediated by cross-reactive T cell responses and mediate both protective effects, immune enhancement and can induce immunopathology. In the past decade she has published and spoken on numerous aspects of the heterologous immunity and CD8 T cell cross-reactivity.


    Mechanisms of viral immunology: heterologous immunity and CD8 T cell crossreactivity during viral infections.

    A comprehensive understanding of the mechanisms associated with the generation and modulation of immunological T cell memory will lead to a better understanding of how the immune system controls viral infections but also causes immune-mediated pathology. Our studies with viruses in murine systems have focused on virus-specific memory T cell populations, which demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. Memory T cells laid down as a consequence of one infection can influence protective immunity and immunopathology associated with a second unrelated virus. We have referred to this phenomenon as T cell-dependent heterologous immunity and immunopathology. The focus of our work is to develop a better understanding of the mechanisms associated with the induction of heterologous immunity, specifically the role cross-reactive memory T cell responses and cytokines play in decreasing or augmenting viral replication and altering immunopathology. We have identified a matrix of cross-reactive epitopes between viruses, and developed both systemic and respiratory infection model systems. We use several virus systems, but focus on lymphocytic chorimeningitis (LCMV) and Pichinde (PV) viruses, distantly related arenaviruses whose T cell responses are well defined, and on the poxvirus vaccinia (VV), which is used as a vaccine for smallpox and as a recombinant vaccine and vector for many antigens.

    Our studies in human viral infections on heterologous immunity and cross-reactive T cell responses during Epstein Barr virus (EBV) infection only begin to scratch the surface of the prevalence and potential impact of cross-reactive T cell responses on both vaccine development and immunopathology. There is very little understanding of the structural and functional interaction of one TCR with two different ligands. We have identified directly ex vivo and in bulk T cell cultures HLA-A2-restricted cross-reactive CD8 T cell responses that recognize both EBV BMLF-1 and influenza A M1 HLA-A2 restricted epitopes. These cross-reactive T cells were found to participate in acute infectious mononucleosis (IM). Five of 8 young adult HLA-A2+ patients experiencing IM had an increased number of influenza virus (FLU)-M158-66 specific CD8+ T cells in their peripheral blood as compared to healthy donors. Two of 5 IM patients with augmented FLU-M1 responses had high levels of tetramer-defined cross-reactive cells as measured directly ex vivo in their peripheral blood. EBV likely activates multiple populations of cross-reactive memory cells involved in the development of IM, and we have been able to provide evidence that those specific to FLU-M1 can contribute to this phenomenon. In order to better understand how cross-reactive CD8 T cells may be modulating disease outcome by enhancing viral clearance or inducing immunopathology, such as that seen in IM, we continue to characterize the cross-reactive TCR, both functionally and structurally, and examine how cross-reactivity influences the evolution of antigen-specific TCR repertoire development and disease outcome in both mice and humans during viral infections.

    Collapse Rotation Projects

    Rotation Projects for graduate students:

    1. Examining the role of cross-reactive CD8 memory T cells in mediating the EBV-induced infectious mononucleosis syndrome in humans.
    2. Examining the role of cross-reactive CD8 memory T cells and cytokines in murine models of viral infection. Examining the mechanisms used by these memory T cells to unrelated infections to modulate disease outcome either for the bad or the good.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antunes DA, Baker BM, Cornberg M, Selin LK. Editorial: Quantification and prediction of T-cell cross-reactivity through experimental and computational methods. Front Immunol. 2024; 15:1377259. PMID: 38444853.
    2. Gil A, Hoag GE, Salerno JP, Hornig M, Klimas N, Selin LK. Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series. Brain Behav Immun Health. 2024 Mar; 36:100720. PMID: 38327880.
    3. Benn CS, Amenyogbe N, Bj?rkman A, Dom?nguez-Andr?s J, Fish EN, Flanagan KL, Klein SL, Kollmann TR, Kyvik KO, Netea MG, Rod NH, Schaltz-Buchholzer F, Shann F, Selin L, Thysen SM, Aaby P. Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines. Drug Saf. 2023 05; 46(5):439-448. PMID: 37074598.
      Citations:    Fields:    Translation:HumansPHPublic Health
    4. Clark F, Gil A, Thapa I, Aslan N, Ghersi D, Selin LK. Cross-reactivity influences changes in human influenza A virus and Epstein Barr virus specific CD8 memory T cell receptor alpha and beta repertoires between young and old. Front Immunol. 2022; 13:1011935. PMID: 36923729.
      Citations: 1     Fields:    Translation:HumansCells
    5. Mischke J, Klein S, Seamann A, Prinz I, Selin L, Ghersi D, Cornberg M, Kraft ARM. Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge. Viruses. 2022 10 18; 14(10). PMID: 36298848.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Ehrlich R, Kamga L, Gil A, Luzuriaga K, Selin LK, Ghersi D. SwarmTCR: a computational approach to predict the specificity of T cell receptors. BMC Bioinformatics. 2021 Sep 07; 22(1):422. PMID: 34493215.
      Citations: 4     Fields:    
    7. Kenney LL, Carter EP, Gil A, Selin LK. T cells in the brain enhance neonatal mortality during peripheral LCMV infection. PLoS Pathog. 2021 01; 17(1):e1009066. PMID: 33400715.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Gil A, Kamga L, Chirravuri-Venkata R, Aslan N, Clark F, Ghersi D, Luzuriaga K, Selin LK. Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor a and ? Repertoires. mBio. 2020 03 17; 11(2). PMID: 32184241.
      Citations: 11     Fields:    Translation:HumansCells
    9. Kamga L, Gil A, Song I, Brody R, Ghersi D, Aslan N, Stern LJ, Selin LK, Luzuriaga K. CDR3a?drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection. PLoS Pathog. 2019 11; 15(11):e1008122. PMID: 31765434.
      Citations: 14     Fields:    Translation:HumansCells
    10. Weiss ER, Lamers SL, Henderson JL, Melnikov A, Somasundaran M, Garber M, Selin L, Nusbaum C, Luzuriaga K. Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection. J Virol. 2018 01 15; 92(2). PMID: 29093087.
      Citations: 21     Fields:    Translation:HumansCells
    11. Aslan N, Watkin LB, Gil A, Mishra R, Clark FG, Welsh RM, Ghersi D, Luzuriaga K, Selin LK. Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires. mBio. 2017 Dec 05; 8(6). PMID: 29208744.
      Citations: 22     Fields:    Translation:HumansCells
    12. Antunes DA, Rigo MM, Freitas MV, Mendes MFA, Sinigaglia M, Liz?e G, Kavraki LE, Selin LK, Cornberg M, Vieira GF. Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy. Front Immunol. 2017; 8:1210. PMID: 29046675.
      Citations: 37     Fields:    
    13. Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544. PMID: 28827827.
      Citations: 15     Fields:    Translation:AnimalsCells
    14. Watkin LB, Mishra R, Gil A, Aslan N, Ghersi D, Luzuriaga K, Selin LK. Unique influenza A?cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion. J Allergy Clin Immunol. 2017 10; 140(4):1206-1210. PMID: 28629751.
      Citations: 10     Fields:    Translation:HumansCells
    15. Song I, Gil A, Mishra R, Ghersi D, Selin LK, Stern LJ. Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope. Nat Struct Mol Biol. 2017 04; 24(4):395-406. PMID: 28250417.
      Citations: 51     Fields:    Translation:HumansCells
    16. Che JW, Daniels KA, Selin LK, Welsh RM. Heterologous Immunity and Persistent Murine Cytomegalovirus Infection. J Virol. 2017 Jan 15; 91(2). PMID: 27807227.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Weiss ER, Alter G, Ogembo JG, Henderson JL, Tabak B, Bakis Y, Somasundaran M, Garber M, Selin L, Luzuriaga K. High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis. J Virol. 2017 Jan 01; 91(1). PMID: 27733645.
      Citations: 15     Fields:    Translation:HumansCells
    18. Fish EN, Flanagan KL, Furman D, Klein SL, Kollmann TR, Jeppesen DL, Levy O, Marchant A, Namachivayam S, Netea MG, Plebanski M, Rowland-Jones SL, Selin LK, Shann F, Whittle HC. Changing oral vaccine to inactivated polio vaccine might increase mortality. Lancet. 2016 Mar 12; 387(10023):1054-1055. PMID: 27025182.
      Citations: 9     Fields:    Translation:Humans
    19. Selin LK, Zajac AJ. Editorial overview: Viral immunology. Curr Opin Virol. 2016 Feb; 16:vii-ix. PMID: 26979471.
      Citations:    Fields:    Translation:HumansCells
    20. Kenney LL, Cornberg M, Chen AT, Emonet S, de la Torre JC, Selin LK. Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis. J Virol. 2015 Nov; 89(21):10786-801. PMID: 26269191.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    21. Che JW, Selin LK, Welsh RM. Evaluation of non-reciprocal heterologous immunity between unrelated viruses. Virology. 2015 Aug; 482:89-97. PMID: 25838115.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Gil A, Yassai MB, Naumov YN, Selin LK. Narrowing of human influenza A virus-specific T cell receptor a and ? repertoires with increasing age. J Virol. 2015 Apr; 89(8):4102-16. PMID: 25609818.
      Citations: 49     Fields:    Translation:HumansCells
    23. Gil A, Kenney LL, Mishra R, Watkin LB, Aslan N, Selin LK. Vaccination and heterologous immunity: educating the immune system. Trans R Soc Trop Med Hyg. 2015 Jan; 109(1):62-9. PMID: 25573110.
      Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Che JW, Kraft AR, Selin LK, Welsh RM. Regulatory T cells resist virus infection-induced apoptosis. J Virol. 2015 Feb; 89(4):2112-20. PMID: 25473049.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ. Innate PLZF+CD4+ a? T cells develop and expand in the absence of Itk. J Immunol. 2014 Jul 15; 193(2):673-87. PMID: 24928994.
      Citations: 15     Fields:    Translation:AnimalsCells
    26. Cornberg M, Kenney LL, Chen AT, Waggoner SN, Kim SK, Dienes HP, Welsh RM, Selin LK. Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response. Front Immunol. 2013; 4:475. PMID: 24391647.
      Citations: 50     Fields:    
    27. Kraft AR, Wlodarczyk MF, Kenney LL, Selin LK. PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol. 2013 Dec; 87(23):12636-47. PMID: 24049180.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    28. Benn CS, Netea MG, Selin LK, Aaby P. A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol. 2013 Sep; 34(9):431-9. PMID: 23680130.
      Citations: 220     Fields:    Translation:HumansAnimalsPHPublic Health
    29. Wlodarczyk MF, Kraft AR, Chen HD, Kenney LL, Selin LK. Anti-IFN-? and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cells. J Immunol. 2013 Mar 15; 190(6):2736-46. PMID: 23408839.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    30. Chen AT, Cornberg M, Gras S, Guillonneau C, Rossjohn J, Trees A, Emonet S, de la Torre JC, Welsh RM, Selin LK. Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope. PLoS Pathog. 2012; 8(4):e1002633. PMID: 22536152.
      Citations: 22     Fields:    Translation:AnimalsCells
    31. Waggoner SN, Cornberg M, Selin LK, Welsh RM. Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2011 Nov 20; 481(7381):394-8. PMID: 22101430.
      Citations: 314     Fields:    Translation:HumansAnimalsCells
    32. Flanagan KL, Klein SL, Skakkebaek NE, Marriott I, Marchant A, Selin L, Fish EN, Prentice AM, Whittle H, Benn CS, Aaby P. Sex differences in the vaccine-specific and non-targeted effects of vaccines. Vaccine. 2011 Mar 16; 29(13):2349-54. PMID: 21300095.
      Citations: 20     Fields:    Translation:Humans
    33. Calcagno C, Puzone R, Pearson YE, Cheng Y, Ghersi D, Selin LK, Welsh RM, Celada F. Computer simulations of heterologous immunity: highlights of an interdisciplinary cooperation. Autoimmunity. 2011 Jun; 44(4):304-14. PMID: 21271821.
      Citations: 2     Fields:    Translation:HumansAnimals
    34. Selin LK, Wlodarczyk MF, Kraft AR, Nie S, Kenney LL, Puzone R, Celada F. Heterologous immunity: immunopathology, autoimmunity and protection during viral infections. Autoimmunity. 2011 Jun; 44(4):328-47. PMID: 21250837.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    35. Pearson YE, Cheng Y, Selin LK, Puzone R, Celada F. Systematic simulation of cross-reactivity predicts ambiguity in Tk memory: it may save lives of the infected, but limits specificities vital for further responses. Autoimmunity. 2011 Jun; 44(4):315-27. PMID: 21231890.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    36. Tirabassi RS, Ace CI, Levchenko T, Torchilin VP, Selin LK, Nie S, Guberski DL, Yang K. A mucosal vaccination approach for herpes simplex virus type 2. Vaccine. 2011 Jan 29; 29(5):1090-8. PMID: 21134447.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK. Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. J Immunol. 2010 Dec 01; 185(11):6753-64. PMID: 21048112.
      Citations: 40     Fields:    Translation:HumansCells
    38. Shen ZT, Brehm MA, Daniels KA, Sigalov AB, Selin LK, Welsh RM, Stern LJ. Bi-specific MHC heterodimers for characterization of cross-reactive T cells. J Biol Chem. 2010 Oct 22; 285(43):33144-33153. PMID: 20729210.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    39. Welsh RM, Che JW, Brehm MA, Selin LK. Heterologous immunity between viruses. Immunol Rev. 2010 May; 235(1):244-66. PMID: 20536568.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    40. Nie S, Lin SJ, Kim SK, Welsh RM, Selin LK. Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire. Am J Pathol. 2010 May; 176(5):2107-12. PMID: 20348239.
      Citations: 20     Fields:    Translation:AnimalsCells
    41. Cornberg M, Clute SC, Watkin LB, Saccoccio FM, Kim SK, Naumov YN, Brehm MA, Aslan N, Welsh RM, Selin LK. CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections. J Immunol. 2010 Mar 15; 184(6):2825-38. PMID: 20164414.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    42. Nie S, Cornberg M, Selin LK. Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity. J Immunol. 2009 Nov 15; 183(10):6554-60. PMID: 19846867.
      Citations: 11     Fields:    Translation:AnimalsCells
    43. Munitic I, Decaluwe H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, Le Bon A, Selin LK, Rivi?re Y, Di Santo JP, Borrow P, Rocha B. Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection. J Virol. 2009 Nov; 83(22):11795-807. PMID: 19726518.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Welsh RM, Selin LK. Attrition of memory CD8 T cells. Nature. 2009 Jun 04; 459(7247):E3-4; discussion E4. PMID: 19494857.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    45. Cheng Y, Ghersi D, Calcagno C, Selin LK, Puzone R, Celada F. A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and na?ve responses. Vaccine. 2009 Feb 05; 27(6):833-45. PMID: 19101600.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    46. Naumov YN, Naumova EN, Yassai MB, Kota K, Welsh RM, Selin LK. Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol. 2008 Nov 15; 181(10):7407-19. PMID: 18981164.
      Citations: 24     Fields:    Translation:HumansCells
    47. Yang K, Whalen BJ, Tirabassi RS, Selin LK, Levchenko TS, Torchilin VP, Kislauskis EH, Guberski DL. A DNA vaccine prime followed by a liposome-encapsulated protein boost confers enhanced mucosal immune responses and protection. J Immunol. 2008 May 01; 180(9):6159-67. PMID: 18424737.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    48. Selin LK, Brehm MA. Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity. J Am Soc Nephrol. 2007 Aug; 18(8):2268-77. PMID: 17634431.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    49. Cornberg M, Sheridan BS, Saccoccio FM, Brehm MA, Selin LK. Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry. J Virol. 2007 Jan; 81(2):934-44. PMID: 17079318.
      Citations: 23     Fields:    Translation:AnimalsCells
    50. Naumov YN, Naumova EN, Clute SC, Watkin LB, Kota K, Gorski J, Selin LK. Complex T cell memory repertoires participate in recall responses at extremes of antigenic load. J Immunol. 2006 Aug 01; 177(3):2006-14. PMID: 16849515.
      Citations: 23     Fields:    Translation:HumansCells
    51. Selin LK, Brehm MA, Naumov YN, Cornberg M, Kim SK, Clute SC, Welsh RM. Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity. Immunol Rev. 2006 Jun; 211:164-81. PMID: 16824126.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    52. Cornberg M, Chen AT, Wilkinson LA, Brehm MA, Kim SK, Calcagno C, Ghersi D, Puzone R, Celada F, Welsh RM, Selin LK. Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest. 2006 May; 116(5):1443-56. PMID: 16614754.
      Citations: 82     Fields:    Translation:AnimalsCells
    53. Bahl K, Kim SK, Calcagno C, Ghersi D, Puzone R, Celada F, Selin LK, Welsh RM. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol. 2006 Apr 01; 176(7):4284-95. PMID: 16547266.
      Citations: 72     Fields:    Translation:AnimalsCells
    54. Welsh RM, Kim SK, Cornberg M, Clute SC, Selin LK, Naumov YN. The privacy of T cell memory to viruses. Curr Top Microbiol Immunol. 2006; 311:117-53. PMID: 17048707.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    55. Clute SC, Watkin LB, Cornberg M, Naumov YN, Sullivan JL, Luzuriaga K, Welsh RM, Selin LK. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest. 2005 Dec; 115(12):3602-12. PMID: 16308574.
      Citations: 99     Fields:    Translation:HumansCells
    56. Kim SK, Cornberg M, Wang XZ, Chen HD, Selin LK, Welsh RM. Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med. 2005 Feb 21; 201(4):523-33. PMID: 15710651.
      Citations: 81     Fields:    Translation:AnimalsCells
    57. Selin LK, Cornberg M, Brehm MA, Kim SK, Calcagno C, Ghersi D, Puzone R, Celada F, Welsh RM. CD8 memory T cells: cross-reactivity and heterologous immunity. Semin Immunol. 2004 Oct; 16(5):335-47. PMID: 15528078.
      Citations: 63     Fields:    Translation:AnimalsCells
    58. Brehm MA, Selin LK, Welsh RM. CD8 T cell responses to viral infections in sequence. Cell Microbiol. 2004 May; 6(5):411-21. PMID: 15056212.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    59. Selin LK, Cornberg M. Embedding T cells in the matrix. Nat Med. 2004 Apr; 10(4):343-5. PMID: 15057225.
      Citations:    Fields:    Translation:AnimalsCells
    60. Selin LK, Welsh RM. Plasticity of T cell memory responses to viruses. Immunity. 2004 Jan; 20(1):5-16. PMID: 14738760.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    61. Welsh RM, Selin LK, Szomolanyi-Tsuda E. Immunological memory to viral infections. Annu Rev Immunol. 2004; 22:711-43. PMID: 15032594.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    62. Chen HD, Fraire AE, Joris I, Welsh RM, Selin LK. Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol. 2003 Oct; 163(4):1341-55. PMID: 14507643.
      Citations: 77     Fields:    Translation:AnimalsCells
    63. Wang XZ, Stepp SE, Brehm MA, Chen HD, Selin LK, Welsh RM. Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Immunity. 2003 May; 18(5):631-42. PMID: 12753740.
      Citations: 32     Fields:    Translation:AnimalsCells
    64. Naumov YN, Naumova EN, Hogan KT, Selin LK, Gorski J. A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses. J Immunol. 2003 Apr 15; 170(8):3994-4001. PMID: 12682227.
      Citations: 40     Fields:    Translation:HumansCells
    65. Kim SK, Brehm MA, Welsh RM, Selin LK. Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol. 2002 Jul 01; 169(1):90-8. PMID: 12077233.
      Citations: 48     Fields:    Translation:AnimalsCells
    66. Brehm MA, Pinto AK, Daniels KA, Schneck JP, Welsh RM, Selin LK. T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat Immunol. 2002 Jul; 3(7):627-34. PMID: 12055626.
      Citations: 114     Fields:    Translation:AnimalsCells
    67. Welsh RM, Selin LK. No one is naive: the significance of heterologous T-cell immunity. Nat Rev Immunol. 2002 Jun; 2(6):417-26. PMID: 12093008.
      Citations: 210     Fields:    Translation:HumansAnimalsCells
    68. Selin LK, Brehm MA, Kim SK, Chen HD. Heterologous immunity and the CD8 T cell network. Springer Semin Immunopathol. 2002; 24(2):149-68. PMID: 12503062.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    69. Chen HD, Fraire AE, Joris I, Brehm MA, Welsh RM, Selin LK. Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol. 2001 Nov; 2(11):1067-76. PMID: 11668342.
      Citations: 124     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    70. Selin LK, Santolucito PA, Pinto AK, Szomolanyi-Tsuda E, Welsh RM. Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells. J Immunol. 2001 Jun 01; 166(11):6784-94. PMID: 11359837.
      Citations: 52     Fields:    Translation:AnimalsCells
    71. Varga SM, Selin LK, Welsh RM. Independent regulation of lymphocytic choriomeningitis virus-specific T cell memory pools: relative stability of CD4 memory under conditions of CD8 memory T cell loss. J Immunol. 2001 Feb 01; 166(3):1554-61. PMID: 11160196.
      Citations: 21     Fields:    Translation:AnimalsCells
    72. Lin MY, Selin LK, Welsh RM. Evolution of the CD8 T-cell repertoire during infections. Microbes Infect. 2000 Jul; 2(9):1025-39. PMID: 10967283.
      Citations: 10     Fields:    Translation:AnimalsCells
    73. Welsh RM, McNally JM, Brehm MA, Selin LK. Consequences of cross-reactive and bystander CTL responses during viral infections. Virology. 2000 Apr 25; 270(1):4-8. PMID: 10772974.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    74. Selin LK, Lin MY, Kraemer KA, Pardoll DM, Schneck JP, Varga SM, Santolucito PA, Pinto AK, Welsh RM. Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses. Immunity. 1999 Dec; 11(6):733-42. PMID: 10626895.
      Citations: 106     Fields:    Translation:AnimalsCells
    75. Selin LK, Varga SM, Wong IC, Welsh RM. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med. 1998 Nov 02; 188(9):1705-15. PMID: 9802982.
      Citations: 126     Fields:    Translation:AnimalsCellsPHPublic Health
    76. Welsh RM, Lin MY, Lohman BL, Varga SM, Zarozinski CC, Selin LK. Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections. Immunol Rev. 1997 Oct; 159:79-93. PMID: 9416504.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    77. Selin LK, Welsh RM. Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. J Immunol. 1997 Jun 01; 158(11):5366-73. PMID: 9164957.
      Citations: 23     Fields:    Translation:AnimalsCells
    78. Selin LK, Vergilis K, Welsh RM, Nahill SR. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J Exp Med. 1996 Jun 01; 183(6):2489-99. PMID: 8676069.
      Citations: 67     Fields:    Translation:AnimalsCells
    79. Welsh RM, Selin LK, Razvi ES. Role of apoptosis in the regulation of virus-induced T cell responses, immune suppression, and memory. J Cell Biochem. 1995 Oct; 59(2):135-42. PMID: 8904307.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    80. Zarozinski CC, Fynan EF, Selin LK, Robinson HL, Welsh RM. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J Immunol. 1995 Apr 15; 154(8):4010-7. PMID: 7706740.
      Citations: 23     Fields:    Translation:AnimalsCells
    81. Selin LK, Welsh RM. Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes. Curr Opin Immunol. 1994 Aug; 6(4):553-9. PMID: 7524536.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    82. Selin LK, Nahill SR, Welsh RM. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J Exp Med. 1994 Jun 01; 179(6):1933-43. PMID: 8195718.
      Citations: 115     Fields:    Translation:AnimalsCells
    83. Wilkins J, Selin L, Stewart S, Sivananthan K, Stupack D. The interactions of gamma delta T cells with extracellular matrix: receptor expression and utilization patterns. Scand J Immunol. 1992 Aug; 36(2):213-9. PMID: 1380178.
      Citations: 1     Fields:    Translation:HumansCells
    84. Selin LK, Stewart S, Shen C, Mao HQ, Wilkins JA. Reactivity of gamma delta T cells induced by the tumour cell line RPMI 8226: functional heterogeneity of clonal populations and role of GroEL heat shock proteins. Scand J Immunol. 1992 Jul; 36(1):107-17. PMID: 1352063.
      Citations: 9     Fields:    Translation:HumansCells
    85. Freedman MS, Ruijs TC, Selin LK, Antel JP. Peripheral blood gamma-delta T cells lyse fresh human brain-derived oligodendrocytes. Ann Neurol. 1991 Dec; 30(6):794-800. PMID: 1838679.
      Citations: 27     Fields:    Translation:HumansCells
    86. Selin LK, Hammond GW, Aoki FY. Neonatal herpes simplex virus infection in Manitoba, 1980 to 1986, and implications for preventive strategies. Pediatr Infect Dis J. 1988 Oct; 7(10):733-4. PMID: 3263616.
      Citations: 1     Fields:    Translation:Humans
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