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Theo C Manschreck MD, MPH

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPsychiatry
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPsychiatry


    Collapse Biography 
    Collapse education and training
    Carleton College, Northfield, MN, United StatesBAPhilosophy
    Harvard University School of Public Health, Boston, MA, United StatesMPH
    Cornell University, Ithaca, NY, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shahzade C, Chun J, DeLisi LE, Manschreck TC. Patterns in adolescent cannabis use predict the onset and symptom structure of schizophrenia-spectrum disorder. Schizophr Res. 2018 Feb 02. PMID: 29402581.
      View in: PubMed
    2. Pillai A, Schooler NR, Peter D, Looney SW, Goff DC, Kopelowicz A, Lauriello J, Manschreck T, Mendelowitz A, Miller DD, Severe JB, Wilson DR, Ames D, Bustillo J, Kane JM, Buckley PF. Predicting relapse in schizophrenia: Is BDNF a plausible biological marker? Schizophr Res. 2018 Mar; 193:263-268. PMID: 28734907.
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    3. Buckley PF, Schooler NR, Goff DC, Kopelowicz A, Lauriello J, Manschreck TC, Mendelowitz A, Miller DD, Wilson DR, Ames D, Bustillo JR, Kane JM, Looney SW. Comparison of Injectable and Oral Antipsychotics in Relapse Rates in a Pragmatic 30-Month Schizophrenia Relapse Prevention Study. Psychiatr Serv. 2016 Dec 01; 67(12):1370-1372. PMID: 27476806.
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    4. Chun J, Peltier SJ, Yoon D, Manschreck TC, Deldin PJ. Prolongation of ERP latency and reaction time (RT) in simultaneous EEG/fMRI data acquisition. J Neurosci Methods. 2016 Aug 1; 268:78-86. PMID: 27172845.
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    5. Boshes RA, Manschreck TC. Less is more Redux: Scheduled intermittent dosing to protect/prevent cognitive deterioration in schizophrenia. Med Hypotheses. 2016 May; 90:79-81. PMID: 27063092.
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    6. Manschreck TC, Chun J, Merrill AM, Maher BA, Boshes RA, Glatt SJ, Faraone SV, Tsuang MT, Seidman LJ. Impaired motor performance in adolescents at familial high-risk for schizophrenia. Schizophr Res. 2015 Oct; 168(1-2):44-9. PMID: 26165939.
      View in: PubMed
    7. Buckley PF, Schooler NR, Goff DC, Hsiao J, Kopelowicz A, Lauriello J, Manschreck T, Mendelowitz AJ, Miller del D, Severe JB, Wilson DR, Ames D, Bustillo J, Mintz J, Kane JM. Comparison of SGA oral medications and a long-acting injectable SGA: the PROACTIVE study. Schizophr Bull. 2015 Mar; 41(2):449-59. PMID: 24870446.
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    8. Chun J, Karam ZN, Marzinzik F, Kamali M, O'Donnell L, Tso IF, Manschreck TC, McInnis M, Deldin PJ. Can P300 distinguish among schizophrenia, schizoaffective and bipolar I disorders? An ERP study of response inhibition. Schizophr Res. 2013 Dec; 151(1-3):175-84. PMID: 24210871.
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    9. Thermenos HW, Whitfield-Gabrieli S, Seidman LJ, Kuperberg G, Juelich RJ, Divatia S, Riley C, Jabbar GA, Shenton ME, Kubicki M, Manschreck T, Keshavan MS, DeLisi LE. Altered language network activity in young people at familial high-risk for schizophrenia. Schizophr Res. 2013 Dec; 151(1-3):229-37. PMID: 24176576.
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    10. Goff DC, McEvoy JP, Citrome L, Mech AW, Bustillo JR, Gil R, Buckley P, Manschreck TC, Achtyes ED, Macklin EA. High-dose oral ziprasidone versus conventional dosing in schizophrenia patients with residual symptoms: the ZEBRAS study. J Clin Psychopharmacol. 2013 Aug; 33(4):485-90. PMID: 23775057.
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    11. Scala S, Pousada A, Stone WS, Thermenos HW, Manschreck TC, Tsuang MT, Faraone SV, Seidman LJ. Verbal and visual-spatial memory impairment in youth at familial risk for schizophrenia or affective psychosis: a pilot study. Schizophr Res. 2013 Mar; 144(1-3):122-8. PMID: 23312552.
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    12. Osser DN, Roudsari MJ, Manschreck T. The psychopharmacology algorithm project at the Harvard South Shore Program: an update on schizophrenia. Harv Rev Psychiatry. 2013 Jan-Feb; 21(1):18-40. PMID: 23656760.
      View in: PubMed
    13. Manschreck TC, Merrill AM, Jabbar G, Chun J, Delisi LE. Frequency of normative word associations in the speech of individuals at familial high-risk for schizophrenia. Schizophr Res. 2012 Sep; 140(1-3):99-103. PMID: 22819779.
      View in: PubMed
    14. Galvez-Buccollini JA, Proal AC, Tomaselli V, Trachtenberg M, Coconcea C, Chun J, Manschreck T, Fleming J, Delisi LE. Association between age at onset of psychosis and age at onset of cannabis use in non-affective psychosis. Schizophr Res. 2012 Aug; 139(1-3):157-60. PMID: 22727454.
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    15. Boshes RA, Manschreck TC, Konigsberg W. Genetics of the schizophrenias: a model accounting for their persistence and myriad phenotypes. Harv Rev Psychiatry. 2012 May-Jun; 20(3):119-29. PMID: 22716503.
      View in: PubMed
    16. Stroup TS, Appelbaum PS, Gu H, Hays S, Swartz MS, Keefe RS, Kim SY, Manschreck TC, Boshes RA, McEvoy JP, Lieberman JA. Longitudinal consent-related abilities among research participants with schizophrenia: results from the CATIE study. Schizophr Res. 2011 Aug; 130(1-3):47-52. PMID: 21561740.
      View in: PubMed
    17. Chan RC, Wang Y, Zhao Q, Yan C, Xu T, Gong QY, Manschreck TC. Neurological soft signs in individuals with schizotypal personality features. Aust N Z J Psychiatry. 2010 Sep; 44(9):800-4. PMID: 20815666.
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    18. Chan RC, McAlonan GM, Yang B, Lin L, Shum D, Manschreck TC. Prevalence of neurological soft signs and their neuropsychological correlates in typically developing Chinese children and Chinese children with ADHD. Dev Neuropsychol. 2010; 35(6):698-711. PMID: 21038161.
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    19. Chan RC, Wang Y, Wang L, Chen EY, Manschreck TC, Li ZJ, Yu X, Gong QY. Neurological soft signs and their relationships to neurocognitive functions: a re-visit with the structural equation modeling design. PLoS One. 2009; 4(12):e8469. PMID: 20041110.
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    20. Manschreck TC, Boshes RA. The CATIE schizophrenia trial: results, impact, controversy. Harv Rev Psychiatry. 2007 Sep-Oct; 15(5):245-58. PMID: 17924259.
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    21. Lenzenweger MF, Miller AB, Maher BA, Manschreck TC. Schizotypy and individual differences in the frequency of normal associations in verbal utterances. Schizophr Res. 2007 Sep; 95(1-3):96-102. PMID: 17628440.
      View in: PubMed
    22. Goff DC, Lamberti JS, Leon AC, Green MF, Miller AL, Patel J, Manschreck T, Freudenreich O, Johnson SA. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb; 33(3):465-72. PMID: 17487227.
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    23. Keefe RS, Bilder RM, Harvey PD, Davis SM, Palmer BW, Gold JM, Meltzer HY, Green MF, Miller DD, Canive JM, Adler LW, Manschreck TC, Swartz M, Rosenheck R, Perkins DO, Walker TM, Stroup TS, McEvoy JP, Lieberman JA. Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology. 2006 Sep; 31(9):2033-46. PMID: 16641947.
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    24. Manschreck TC, Khan NL. Recent advances in the treatment of delusional disorder. Can J Psychiatry. 2006 Feb; 51(2):114-9. PMID: 16989110.
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    25. Maher BA, Manschreck TC, Linnet J, Candela S. Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls. Schizophr Res. 2005 Oct 15; 78(2-3):219-24. PMID: 16005190.
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    26. Lenzenweger MF, Maher BA, Manschreck TC. Paul E. Meehl's influence on experimental psychopathology: fruits of the nexus of schizotypy and schizophrenia, neurology, and methodology. J Clin Psychol. 2005 Oct; 61(10):1295-315. PMID: 16041784.
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    27. Stroup S, Appelbaum P, Swartz M, Patel M, Davis S, Jeste D, Kim S, Keefe R, Manschreck T, McEvoy J, Lieberman J. Decision-making capacity for research participation among individuals in the CATIE schizophrenia trial. Schizophr Res. 2005 Dec 1; 80(1):1-8. PMID: 16182516.
      View in: PubMed
    28. Manschreck TC, Maher BA, Candela SF. Earlier age of first diagnosis in schizophrenia is related to impaired motor control. Schizophr Bull. 2004; 30(2):351-60. PMID: 15279052.
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    29. Boshes RA, Manschreck TC. Review of antipsychotic medication administration: a proposal of intermittent dosing. Schizophr Bull. 2002; 28(2):203-22. PMID: 12693428.
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    30. Boshes RA, Manschreck TC, Desrosiers J, Candela S, Hanrahan-Boshes M. Initiation of clozapine therapy in a patient with preexisting leukopenia: a discussion of the rationale of current treatment options. Ann Clin Psychiatry. 2001 Dec; 13(4):233-7. PMID: 11958365.
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    31. Manschreck TC. Placebo studies: lessons from psychiatric research. Psychiatr Ann. 2001 Feb; 31(2):130-6. PMID: 12785378.
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    32. Manschreck TC, Maher BA, Candela SF, Redmond D, Yurgelun-Todd D, Tsuang M. Impaired verbal memory is associated with impaired motor performance in schizophrenia: relationship to brain structure. Schizophr Res. 2000 May 25; 43(1):21-32. PMID: 10828412.
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    33. Manschreck TC, Maher BA, Winzig L, Candela SF, Beaudette S, Boshes R. Age disorientation in schizophrenia: an indicator of progressive and severe psychopathology, not institutional isolation. J Neuropsychiatry Clin Neurosci. 2000; 12(3):350-8. PMID: 10956568.
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    34. Manschreck TC, Redmond DA, Candela SF, Maher BA. Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia. J Neuropsychiatry Clin Neurosci. 1999; 11(4):481-9. PMID: 10570762.
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    35. Maher BA, Manschreck TC, Yurgelun-Todd DA, Tsuang MT. Hemispheric asymmetry of frontal and temporal gray matter and age of onset in schizophrenia. Biol Psychiatry. 1998 Sep 15; 44(6):413-7. PMID: 9777170.
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    36. White MS, Maher BA, Manschreck TC. Hemispheric specialization in schizophrenics with perceptual aberration. Schizophr Res. 1998 Aug 17; 32(3):161-70. PMID: 9720121.
      View in: PubMed
    37. Manschreck TC, Maher BA, Beaudette SM, Redmond DA. Context memory in schizoaffective and schizophrenic disorders. Schizophr Res. 1997 Aug 29; 26(2-3):153-61. PMID: 9323346.
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    38. Blyler CR, Maher BA, Manschreck TC, Fenton WS. Line drawing as a possible measure of lateralized motor performance in schizophrenia. Schizophr Res. 1997 Jul 25; 26(1):15-23. PMID: 9376334.
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    39. Maher BA, Manschreck TC, Redmond D, Beaudette S. Length of illness and the gradient from positive to negative semantic priming in schizophrenic patients. Schizophr Res. 1996 Nov 15; 22(2):127-32. PMID: 8958596.
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    40. Manschreck TC. Delusional disorder: the recognition and management of paranoia. J Clin Psychiatry. 1996; 57 Suppl 3:32-8; discussion 49. PMID: 8626368.
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    41. Manschreck TC. Pathogenesis of delusions. Psychiatr Clin North Am. 1995 Jun; 18(2):213-29. PMID: 7659595.
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    42. Maher BA, Manschreck TC, Woods BT, Yurgelun-Todd DA, Tsuang MT. Frontal brain volume and context effects in short-term recall in schizophrenia. Biol Psychiatry. 1995 Feb 1; 37(3):144-50. PMID: 7727622.
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    43. Manschreck TC, Redmond DA, Beaudette SM. Clozapine in the back wards. Ann Clin Psychiatry. 1994 Dec; 6(4):215-25. PMID: 7647831.
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    44. Welch J, Manschreck T, Redmond D. Clozapine-induced seizures and EEG changes. J Neuropsychiatry Clin Neurosci. 1994; 6(3):250-6. PMID: 7950347.
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    45. Manschreck TC. The treatment of cocaine abuse. Psychiatr Q. 1993; 64(2):183-97. PMID: 8316599.
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    46. Manschreck TC, Leighton AH. Reducing disability in mood disorders and schizophrenia. Hosp Community Psychiatry. 1992 Feb; 43(2):179-80. PMID: 1572619.
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    47. Manschreck TC, Maher BA, Rosenthal JE, Berner J. Reduced primacy and related features in schizophrenia. Schizophr Res. 1991 Jul-Aug; 5(1):35-41. PMID: 1677264.
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    48. Manschreck TC, Maher B, Celada MT, Schneyer M, Fernandez R. Object chaining and thought disorder in schizophrenic speech. Psychol Med. 1991 May; 21(2):443-6. PMID: 1876648.
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    49. Manschreck TC, Schneyer ML, Weisstein CC, Laughery J, Rosenthal J, Celada T, Berner J. Freebase cocaine and memory. Compr Psychiatry. 1990 Jul-Aug; 31(4):369-75. PMID: 2387150.
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    50. Wilson SN, Surman OS, Colvin R, Ozonoff D, Gelenberg AJ, Jenike MA, Manschreck T, Pato C. Unusual lymphocyte subset distribution in some depressed patients. J Clin Psychiatry. 1990 Feb; 51(2):51-2. PMID: 2137122.
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    51. Manschreck TC, Keuthen NJ, Schneyer ML, Celada MT, Laughery J, Collins P. Abnormal involuntary movements and chronic schizophrenic disorders. Biol Psychiatry. 1990 Jan 15; 27(2):150-8. PMID: 2294979.
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    52. Garber HJ, Weilburg JB, Duffy FH, Manschreck TC. Clinical use of topographic brain electrical activity mapping in psychiatry. J Clin Psychiatry. 1989 Jun; 50(6):205-11. PMID: 2637676.
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    53. Maher BA, Manschreck TC, Weisstein CC, Schneyer ML, Okunieff R. Cloze analysis in schizophrenic speech: scoring method and raters' education. Percept Mot Skills. 1988 Dec; 67(3):911-8. PMID: 3226847.
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    54. Zusky PM, Biederman J, Rosenbaum JF, Manschreck TC, Gross CC, Weilberg JB, Gastfriend DR. Adjunct low dose lithium carbonate in treatment-resistant depression: a placebo-controlled study. J Clin Psychopharmacol. 1988 Apr; 8(2):120-4. PMID: 3131389.
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    55. Manschreck TC, Laughery JA, Weisstein CC, Allen D, Humblestone B, Neville M, Podlewski H, Mitra N. Characteristics of freebase cocaine psychosis. Yale J Biol Med. 1988 Mar-Apr; 61(2):115-22. PMID: 3407210.
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    56. Manoach DS, Maher BA, Manschreck TC. Left-handedness and though disorder in the schizophrenias. J Abnorm Psychol. 1988 Feb; 97(1):97-9. PMID: 3351121.
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    57. Garber HJ, Weilburg JB, Buonanno FS, Manschreck TC, New PF. Use of magnetic resonance imaging in psychiatry. Am J Psychiatry. 1988 Feb; 145(2):164-71. PMID: 3341461.
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    58. Beckett A, Manschreck T. Neuropsychiatric complications of HIV infection: public policy implications. N Engl J Public Policy. 1988 Winter-Spring; 4(1):111-9. PMID: 11650192.
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    59. Manschreck TC, Maher BA, Milavetz JJ, Ames D, Weisstein CC, Schneyer ML. Semantic priming in thought disordered schizophrenic patients. Schizophr Res. 1988 Jan-Feb; 1(1):61-6. PMID: 3154508.
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    60. Manschreck TC, Allen DF, Neville M. Freebase psychosis: cases from a Bahamian epidemic of cocaine abuse. Compr Psychiatry. 1987 Nov-Dec; 28(6):555-64. PMID: 3691079.
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    61. Beckett A, Summergrad P, Manschreck T, Vitagliano H, Henderson M, Buttolph ML, Jenike M. Symptomatic HIV infection of the CNS in a patient without clinical evidence of immune deficiency. Am J Psychiatry. 1987 Oct; 144(10):1342-4. PMID: 3661770.
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    62. Manschreck TC, Ames D, Maher BA, Schneyer ML. Impoverished written responses and negative features of schizophrenia. Percept Mot Skills. 1987 Jun; 64(3 Pt 2):1163-9. PMID: 3627917.
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    63. Zusky P, Manschreck TC, Blanchard C, Rosenbaum J, Elliot C, Lou P. Dothiepin hydrochloride: treatment efficacy and safety. J Clin Psychiatry. 1986 Oct; 47(10):504-7. PMID: 3531188.
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    64. Pollack MH, Manschreck TC. Oculocutaneous albinism and schizophrenia. Biol Psychiatry. 1986 Jul; 21(8-9):830-3. PMID: 3730462.
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    65. Uzogara E, Sheehan DV, Manschreck TC, Jones KJ. A combination drug treatment for acute common migraine. Headache. 1986 May; 26(5):231-6. PMID: 3522481.
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    66. Manschreck TC, Maher BA, Waller NG, Ames D, Latham CA. Deficient motor synchrony in schizophrenic disorders: clinical correlates. Biol Psychiatry. 1985 Sep; 20(9):990-1002. PMID: 4027317.
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    67. Manschreck TC, Maher BA, Hoover TM, Ames D. Repetition in schizophrenic speech. Lang Speech. 1985 Jul-Sep; 28 ( Pt 3):255-68. PMID: 3836315.
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    68. Sederer LI, Katz B, Manschreck TC. Inpatient psychiatry: perspectives from the general, the private, and the state hospital. Gen Hosp Psychiatry. 1984 Jul; 6(3):180-90. PMID: 6745644.
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    69. Manschreck TC, Ames D. Neurologic features and psychopathology in schizophrenic disorders. Biol Psychiatry. 1984 May; 19(5):703-19. PMID: 6145453.
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    70. Manschreck TC, Maher BA, Hoover TM, Ames D. The type--token ratio in schizophrenic disorders: clinical and research value. Psychol Med. 1984 Feb; 14(1):151-7. PMID: 6709781.
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    71. Maher BA, Manschreck TC, Molino MA. Redundancy, pause distributions and thought disorder in schizophrenia. Lang Speech. 1983 Apr-Jun; 26 ( Pt 2):191-9. PMID: 6664181.
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    72. Sheehan DV, Davidson J, Manschreck T, Van Wyck Fleet J. Lack of efficacy of a new antidepressant (bupropion) in the treatment of panic disorder with phobias. J Clin Psychopharmacol. 1983 Feb; 3(1):28-31. PMID: 6403599.
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    73. Manschreck TC. Psychopathology of motor behavior in schizophrenia. Prog Exp Pers Res. 1983; 12:53-99. PMID: 6364228.
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    74. Manschreck TC, Maher BA, Rucklos ME, Vereen DR. Disturbed voluntary motor activity in schizophrenic disorder. Psychol Med. 1982 Feb; 12(1):73-84. PMID: 6123128.
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    75. Manschreck TC. Current concepts in psychiatry: schizophrenic disorders. N Engl J Med. 1981 Dec 31; 305(27):1628-32. PMID: 7031470.
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    76. Latham C, Holzman PS, Manschreck TC, Tole J. Optokinetic nystagmus and pursuit eye movements in schizophrenia. Arch Gen Psychiatry. 1981 Sep; 38(9):997-1003. PMID: 7283672.
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    77. Keller MB, Manschreck TC. The bedside mental status examination--reliability and validity. Compr Psychiatry. 1981 Sep-Oct; 22(5):500-11. PMID: 7187871.
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    78. Manschreck TC, Maher BA, Rucklos ME, Vereen DR, Ader DN. Deficient motor synchrony in schizophrenia. J Abnorm Psychol. 1981 Aug; 90(4):321-8. PMID: 7264062.
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    79. Manschreck TC, Maher BA, Ader DN. Formal thought disorder, the type-token ratio and disturbed voluntary motor movement in schizophrenia. Br J Psychiatry. 1981 Jul; 139:7-15. PMID: 6117348.
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    80. Manschreck TC, Kalotkin M, Jacobson AM. Utility of electromyographic biological feedback in chronic stuttering: a clinical study with follow-up. Percept Mot Skills. 1980 Oct; 51(2):535-40. PMID: 7443374.
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    81. Maher BA, Manschreck TC, Rucklos ME. Contextual constraint and the recall of verbal material in schizophrenia: the effect of thought disorder. Br J Psychiatry. 1980 Jul; 137:69-73. PMID: 7459542.
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    82. Manschreck TC, Maher BA, Rucklos ME. Cloze procedure and written language in schizophrenia. Lang Speech. 1980; 23(Pt 4):323-8. PMID: 7266188.
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    83. Neu C, Manschreck TC, Flocks JM. Renal damage associated with long term use of lithium carbonate. J Clin Psychiatry. 1979 Nov; 40(11):460-3. PMID: 489527.
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    84. Kalotkin M, Manschreck T, O'Brien D. Electromyographic tension levels in stutterers and normal speakers. Percept Mot Skills. 1979 Aug; 49(1):109-10. PMID: 503723.
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    85. Manschreck TC. The assessment of paranoid features. Compr Psychiatry. 1979 Jul-Aug; 20(4):370-7. PMID: 455954.
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    86. Manschreck TC, Kleinman AM. Psychiatry's identity crisis: a critical rational remedy. Gen Hosp Psychiatry. 1979 Jul; 1(2):166-73. PMID: 499787.
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    87. Manschreck TC, Maher BA, Rucklos ME, White MT. The predictability of thought disordered speech in schizophrenic patients. Br J Psychiatry. 1979 Jun; 134:595-601. PMID: 476370.
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    88. Jacobson AM, Manschreck TC, Silverberg E. Behavioral treatment for Raynaud's disease: a comparative study with long-term follow-up. Am J Psychiatry. 1979 Jun; 136(6):844-6. PMID: 375758.
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    89. Manschreck TC, Petri M. The atypical psychoses. Cult Med Psychiatry. 1978 Sep; 2(3):233-68. PMID: 710173.
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    90. Manschreck TC, Petri M. The paranoid syndrome. Lancet. 1978 Jul 29; 2(8083):251-3. PMID: 79043.
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    91. Jacobson AM, Silverberg E, Hackett T, Manschreck T. Treatment of Raynaud's disease: evaluation of a behavioral approach. Psychiatr Clin (Basel). 1978; 11(3):125-31. PMID: 368891.
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    92. Jacobson G, Baldessarini RJ, Manschreck T. Tardive and withdrawal dyskinesia associated with haloperidol. Am J Psychiatry. 1974 Aug; 131(8):910-3. PMID: 4834709.
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