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Michael J Mitchell MD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressUMass Memorial Health Care Inc.
365 Plantation Street, Biotech One
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionAcademic Pathology

    Collapse Biography 
    Collapse education and training
    Boston College, Chestnut Hill, MA, United StatesBSChemistry
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background

      Present Position:
      Director, Microbiology Services
      Department of Hospital Laboratories
      89 Puritan Road
      Waban, MA 02468
      Medical School:
      Yale University School of Medicine, MD (1978)

    Graduate Medical Education:

      1978-1981 Resident in Pediatrics, Yale-New Haven Hospital
      1981-1984 Fellow, Pediatric Infectious Diseases, Johns Hopkins Hospital
      1984-1987 Fellow, Microbiology Service, National Institutes of Health
      1990-1992 Fellow, Combined Program in Human Genetics, Harvard Medical School


      National Board of Medical Examiners (#201579), 1980.
      American Academy of Pediatrics, (#29383), 1983.
      American Board of Pathology, Medical Microbiology, 1986.
      American Board of Medical Genetics, Clinical Cytogenetics, 1993


      The Board of Medical Examiners of the State of Maryland, D33781 (expired 1987).
      Commonwealth of Massachusetts Board of Registration in Medicine, (Reg.#: 58562, Expires 6/18/03).

    Current Academic Appointment(s):

      Assistant Professor, Department of Pathology, University of Massachusetts School of Medicine

    Current Medical Staff Appointment(s):

      Staff Physician, UMass Memorial Group Practice


    I oversee laboratory and clinical aspects of the microbiology laboratories, including aerobicmichael Mitchell andanaerobicbacteriology, mycobacteriology, mycology, parasitology, and virology. I am involved with teachingandtraining of Medical Students, Pathology Residents, and Infectious Diseases Fellows (Department of Medicine). I am a member of the Steering Committee in the Department of Hospital Labs. I sit on the UMMMC Clinical Process Improvement Committee, and chair its Laboratory Advisory subcommittee. I also sit on the UMMMC Pharmacy and Therapeutics Antimicrobial Subcommittee, the UMMMC Infection Control Committee, and theUMMMC Disaster Committee.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shepherd SJ, Issadore D, Mitchell MJ. Microfluidic formulation of nanoparticles for biomedical applications. Biomaterials. 2021 07; 274:120826. PMID: 33965797.
      Citations: 28     Fields:    
    2. Yeom J, Guimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A. Chiral Supraparticles for Controllable Nanomedicine. Adv Mater. 2020 Jan; 32(1):e1903878. PMID: 31686433.
      Citations: 19     Fields:    Translation:HumansCells
    3. Bisso PW, Gaglione S, Guimar?es PPG, Mitchell MJ, Langer R. Nanomaterial Interactions with Human Neutrophils. ACS Biomater Sci Eng. 2018 Dec 10; 4(12):4255-4265. PMID: 31497639.
      Citations: 11     Fields:    
    4. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J Control Release. 2018 11 28; 290:75-87. PMID: 30290244.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    5. Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in Biomaterials for Drug Delivery. Adv Mater. 2018 May 07; e1705328. PMID: 29736981.
      Citations: 120     Fields:    
    6. Guimar?es PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano. 2018 02 27; 12(2):912-931. PMID: 29378114.
      Citations: 35     Fields:    Translation:HumansAnimals
    7. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Lett. 2017 10 11; 17(10):6235-6240. PMID: 28819978.
      Citations: 22     Fields:    Translation:HumansCells
    8. Mitchell MJ, Webster J, Chung A, Guimar?es PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 03 20; 8:14179. PMID: 28317839.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    9. Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. J Control Release. 2016 Feb 10; 223:215-223. PMID: 26732555.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    10. Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015 Dec 01; 309(11):C736-46. PMID: 26447202.
      Citations: 47     Fields:    Translation:HumansCells
    11. Mitchell MJ, Castellanos CA, King MR. Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials. 2015 Jul; 56:179-86. PMID: 25934290.
      Citations: 11     Fields:    Translation:HumansCells
    12. Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. J Biomed Mater Res A. 2015 Oct; 103(10):3407-18. PMID: 25761664.
      Citations: 9     Fields:    Translation:HumansCells
    13. Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J. 2015 Feb 03; 108(3):471-8. PMID: 25650915.
      Citations: 60     Fields:    Translation:AnimalsCells
    14. Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opin Drug Deliv. 2015 Mar; 12(3):375-92. PMID: 25270379.
      Citations: 25     Fields:    Translation:Cells
    15. Bajpai S, Mitchell MJ, King MR, Reinhart-King CA. A microfluidic device to select for cells based on chemotactic phenotype. Technology (Singap World Sci). 2014 Jun; 2(2):101-105. PMID: 24999488.
    16. Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophys J. 2014 May 20; 106(10):2243-53. PMID: 24853753.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    17. Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther. 2014 Jun; 14(6):641-4. PMID: 24791860.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):930-5. PMID: 24395803.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    19. Mitchell MJ, King MR. Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C89-97. PMID: 24133067.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    20. Cao TM, Mitchell MJ, Liesveld J, King MR. Stem cell enrichment with selectin receptors: mimicking the pH environment of trauma. Sensors (Basel). 2013 Sep 17; 13(9):12516-26. PMID: 24048341.
      Citations: 10     Fields:    Translation:HumansCells
    21. Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013; 3:44. PMID: 23467856.
    22. Mitchell MJ, King MR. Fluid Shear Stress Sensitizes Cancer Cells to Receptor-Mediated Apoptosis via Trimeric Death Receptors. New J Phys. 2013 Jan 18; 15:015008. PMID: 25110459.
    23. Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophys J. 2012 Apr 18; 102(8):1804-14. PMID: 22768936.
      Citations: 19     Fields:    Translation:HumansCells
    24. Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. J Control Release. 2012 Jun 28; 160(3):609-17. PMID: 22421423.
      Citations: 28     Fields:    Translation:HumansCells
    25. Mitchell MJ, Castellanos CA, King MR. Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes. J Nanomater. 2012; 2012. PMID: 25152752.
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