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Michael J Mitchell MD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUMass Memorial Health Care Inc.
365 Plantation Street, Biotech One
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPathology
    DivisionAcademic Pathology


    Collapse Biography 
    Collapse education and training
    Boston College, Boston, MA, United StatesBSChemistry
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background

      Present Position:
      Director, Microbiology Services
      Department of Hospital Laboratories
      Address:
      89 Puritan Road
      Waban, MA 02468
      Medical School:
      Yale University School of Medicine, MD (1978)

    Graduate Medical Education:

      1978-1981 Resident in Pediatrics, Yale-New Haven Hospital
      1981-1984 Fellow, Pediatric Infectious Diseases, Johns Hopkins Hospital
      1984-1987 Fellow, Microbiology Service, National Institutes of Health
      1990-1992 Fellow, Combined Program in Human Genetics, Harvard Medical School

    Certification:

      National Board of Medical Examiners (#201579), 1980.
      American Academy of Pediatrics, (#29383), 1983.
      American Board of Pathology, Medical Microbiology, 1986.
      American Board of Medical Genetics, Clinical Cytogenetics, 1993

    Licensure:

      The Board of Medical Examiners of the State of Maryland, D33781 (expired 1987).
      Commonwealth of Massachusetts Board of Registration in Medicine, (Reg.#: 58562, Expires 6/18/03).

    Current Academic Appointment(s):

      Assistant Professor, Department of Pathology, University of Massachusetts School of Medicine

    Current Medical Staff Appointment(s):

      Staff Physician, UMass Memorial Group Practice

    Interests

    I oversee laboratory and clinical aspects of the microbiology laboratories, including aerobicmichael Mitchell andanaerobicbacteriology, mycobacteriology, mycology, parasitology, and virology. I am involved with teachingandtraining of Medical Students, Pathology Residents, and Infectious Diseases Fellows (Department of Medicine). I am a member of the Steering Committee in the Department of Hospital Labs. I sit on the UMMMC Clinical Process Improvement Committee, and chair its Laboratory Advisory subcommittee. I also sit on the UMMMC Pharmacy and Therapeutics Antimicrobial Subcommittee, the UMMMC Infection Control Committee, and theUMMMC Disaster Committee.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Moore GW, Van Cott EM, Cutler JA, Mitchell MJ, Adcock DM. Recommendations for clinical laboratory testing of activated protein C resistance; communication from the SSC of the ISTH. J Thromb Haemost. 2019 Jun 07. PMID: 31317658.
      View in: PubMed
    2. Mukalel AJ, Riley RS, Zhang R, Mitchell MJ. Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy. Cancer Lett. 2019 May 14. PMID: 31100411.
      View in: PubMed
    3. Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019 Jan 08. PMID: 30622344.
      View in: PubMed
    4. Mitchell M, Gattens M, Kavakli K, Liesner R, Payne J, Norton M, Austin S. Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency. Blood Coagul Fibrinolysis. 2018 Nov 29. PMID: 30507709.
      View in: PubMed
    5. Mitchell MJ, Jain RK, Langer R. Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2018 Oct 18. PMID: 30337715.
      View in: PubMed
    6. Zhang R, Billingsley MM, Mitchell MJ. Biomaterials for vaccine-based cancer immunotherapy. J Control Release. 2018 Oct 09. PMID: 30312721.
      View in: PubMed
    7. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J Control Release. 2018 Oct 02. PMID: 30290244.
      View in: PubMed
    8. Auguste Y, Delague V, Desvignes JP, Longepied G, Gnisci A, Besnier P, Levy N, Beroud C, Megarbane A, Metzler-Guillemain C, Mitchell MJ. Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251 Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in Men. Am J Hum Genet. 2018 Sep 06; 103(3):413-420. PMID: 30122541.
      View in: PubMed
    9. Paci M, Elkhatib R, Longepied G, Bourgeois P, Ray PF, Levy N, Mitchell MJ, Metzler-Guillemain C. The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review. Basic Clin Androl. 2018; 28:7. PMID: 29946470.
      View in: PubMed
    10. Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in Biomaterials for Drug Delivery. Adv Mater. 2018 May 07; e1705328. PMID: 29736981.
      View in: PubMed
    11. Guimarães PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano. 2018 Feb 27; 12(2):912-931. PMID: 29378114.
      View in: PubMed
    12. Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2017 11; 17(11):659-675. PMID: 29026204.
      View in: PubMed
    13. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Lett. 2017 Oct 11; 17(10):6235-6240. PMID: 28819978.
      View in: PubMed
    14. Elkhatib RA, Paci M, Longepied G, Saias-Magnan J, Courbière B, Guichaoua MR, Lévy N, Metzler-Guillemain C, Mitchell MJ. Homozygous deletion of SUN5 in three men with decapitated spermatozoa. Hum Mol Genet. 2017 08 15; 26(16):3167-3171. PMID: 28541472.
      View in: PubMed
    15. Paci M, Elkhatib R, Longepied G, Hennebicq S, Bessonat J, Courbière B, Bourgeois P, Levy N, Mitchell MJ, Metzler-Guillemain C. Abnormal retention of nuclear lamina and disorganization of chromatin-related proteins in spermatozoa from DPY19L2-deleted globozoospermic patients. Reprod Biomed Online. 2017 Nov; 35(5):562-570. PMID: 28882431.
      View in: PubMed
    16. Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V, Bourgeois P, Levy N, Branger N, Mitchell MJ, Metzler-Guillemain C. LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction. 2017 Oct; 154(4):387-401. PMID: 28684548.
      View in: PubMed
    17. Kherraf ZE, Christou-Kent M, Karaouzene T, Amiri-Yekta A, Martinez G, Vargas AS, Lambert E, Borel C, Dorphin B, Aknin-Seifer I, Mitchell MJ, Metzler-Guillemain C, Escoffier J, Nef S, Grepillat M, Thierry-Mieg N, Satre V, Bailly M, Boitrelle F, Pernet-Gallay K, Hennebicq S, Fauré J, Bottari SP, Coutton C, Ray PF, Arnoult C. SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes. EMBO Mol Med. 2017 May 29. PMID: 28554943.
      View in: PubMed
    18. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 Mar 20; 8:14179. PMID: 28317839.
      View in: PubMed
    19. Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 Mar 08; 17(3):1326-1335. PMID: 28273716.
      View in: PubMed
    20. Bradshaw H, Mitchell MJ, Edwards CJ, Stolz U, Naser O, Peck A, Patanwala AE. Medication Palatability Affects Physician Prescribing Preferences for Common Pediatric Conditions. Acad Emerg Med. 2016 Nov; 23(11):1243-1247. PMID: 27264915.
      View in: PubMed
    21. Bednarska-Makaruk M, Graban A, Sobczynska-Malefora A, Harrington DJ, Mitchell M, Voong K, Dai L, Lojkowska W, Bochynska A, Ryglewicz D, Wisniewska A, Wehr H. Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia. Exp Gerontol. 2016 Aug; 81:83-91. PMID: 27167582.
      View in: PubMed
    22. Yamauchi Y, Riel JM, Ruthig VA, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29; 351(6272):514-6. PMID: 26823431.
      View in: PubMed
    23. Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development. PLoS One. 2016; 11(1):e0145398. PMID: 26765744.
      View in: PubMed
    24. Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. J Control Release. 2016 Feb 10; 223:215-23. PMID: 26732555.
      View in: PubMed
    25. Decarpentrie F, Ojarikre OA, Mitchell MJ, Burgoyne PS. Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. Chromosoma. 2016 Jun; 125(2):177-88. PMID: 26596988.
      View in: PubMed
    26. Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015 Dec 1; 309(11):C736-46. PMID: 26447202.
      View in: PubMed
    27. Mitchell MJ, Castellanos CA, King MR. Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials. 2015 Jul; 56:179-86. PMID: 25934290.
      View in: PubMed
    28. Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. J Biomed Mater Res A. 2015 Oct; 103(10):3407-18. PMID: 25761664.
      View in: PubMed
    29. Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J. 2015 Feb 3; 108(3):471-8. PMID: 25650915.
      View in: PubMed
    30. Keskin EY, Gürsel T, Kaya Z, Dai L, Koçak Ü, Yenicesu I, Belen FB, Mitchell M. Molecular basis and bleeding manifestations of factor XI deficiency in 11 Turkish families. Blood Coagul Fibrinolysis. 2015 Jan; 26(1):63-8. PMID: 25158988.
      View in: PubMed
    31. Elkhatib R, Longepied G, Paci M, Achard V, Grillo JM, Levy N, Mitchell MJ, Metzler-Guillemain C. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015 Mar; 21(3):225-36. PMID: 25477337.
      View in: PubMed
    32. Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opin Drug Deliv. 2015 Mar; 12(3):375-92. PMID: 25270379.
      View in: PubMed
    33. Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division. PLoS Genet. 2014 Jun; 10(6):e1004444. PMID: 24967676.
      View in: PubMed
    34. Bajpai S, Mitchell MJ, King MR, Reinhart-King CA. A microfluidic device to select for cells based on chemotactic phenotype. Technology (Singap World Sci). 2014 Jun; 2(2):101-105. PMID: 24999488.
      View in: PubMed
    35. Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophys J. 2014 May 20; 106(10):2243-53. PMID: 24853753.
      View in: PubMed
    36. Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther. 2014 Jun; 14(6):641-4. PMID: 24791860.
      View in: PubMed
    37. Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):930-5. PMID: 24395803.
      View in: PubMed
    38. Mitchell MJ, King MR. Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C89-97. PMID: 24133067.
      View in: PubMed
    39. Cao TM, Mitchell MJ, Liesveld J, King MR. Stem cell enrichment with selectin receptors: mimicking the pH environment of trauma. Sensors (Basel). 2013 Sep 17; 13(9):12516-26. PMID: 24048341.
      View in: PubMed
    40. Eckhardt CL, van Velzen AS, Peters M, Astermark J, Brons PP, Castaman G, Cnossen MH, Dors N, Escuriola-Ettingshausen C, Hamulyak K, Hart DP, Hay CR, Haya S, van Heerde WL, Hermans C, Holmström M, Jimenez-Yuste V, Keenan RD, Klamroth R, Laros-van Gorkom BA, Leebeek FW, Liesner R, Mäkipernaa A, Male C, Mauser-Bunschoten E, Mazzucconi MG, McRae S, Meijer K, Mitchell M, Morfini M, Nijziel M, Oldenburg J, Peerlinck K, Petrini P, Platokouki H, Reitter-Pfoertner SE, Santagostino E, Schinco P, Smiers FJ, Siegmund B, Tagliaferri A, Yee TT, Kamphuisen PW, van der Bom JG, Fijnvandraat K. Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A. Blood. 2013 Sep 12; 122(11):1954-62. PMID: 23926300.
      View in: PubMed
    41. Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013; 3:44. PMID: 23467856.
      View in: PubMed
    42. Mitchell MJ, King MR. Fluid Shear Stress Sensitizes Cancer Cells to Receptor-Mediated Apoptosis via Trimeric Death Receptors. New J Phys. 2013 Jan 18; 15:015008. PMID: 25110459.
      View in: PubMed
    43. Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophys J. 2012 Apr 18; 102(8):1804-14. PMID: 22768936.
      View in: PubMed
    44. Streichemberger E, Perrin J, Saias-Magnan J, Karsenty G, Malzac P, Grillo JM, Mitchell MJ, Metzler-Guillemain C. Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells. Hum Reprod. 2012 Jul; 27(7):1939-45. PMID: 22508792.
      View in: PubMed
    45. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Hum Mol Genet. 2012 Jun 15; 21(12):2631-45. PMID: 22407129.
      View in: PubMed
    46. Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. J Control Release. 2012 Jun 28; 160(3):609-17. PMID: 22421423.
      View in: PubMed
    47. Schlaberg R, Mitchell MJ, Taggart EW, She RC. Verification of performance specifications for a US Food and Drug Administration-approved molecular microbiology test: Clostridium difficile cytotoxin B using the Becton, Dickinson and Company GeneOhm Cdiff assay. Arch Pathol Lab Med. 2012 Jan; 136(1):20-5. PMID: 22208483.
      View in: PubMed
    48. Mitchell MJ, Castellanos CA, King MR. Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes. J Nanomater. 2012; 2012. PMID: 25152752.
      View in: PubMed
    49. Kichine E, Rozé V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, Lévy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod. 2012 Feb; 27(2):615-24. PMID: 22158087.
      View in: PubMed
    50. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93. PMID: 21530259.
      View in: PubMed
    51. Hayden RT, Wick MT, Rodriguez AB, Caliendo AM, Mitchell MJ, Ginocchio CC. A survey-based assessment of United States clinical laboratory response to the 2009 H1N1 influenza outbreak. Arch Pathol Lab Med. 2010 Nov; 134(11):1671-8. PMID: 21043821.
      View in: PubMed
    52. Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Arch Pathol Lab Med. 2010 Oct; 134(10):1490-503. PMID: 20923306.
      View in: PubMed
    53. Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010 Oct; 25(10):2655-63. PMID: 20716563.
      View in: PubMed
    54. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, Yahaya AA, Chiaroni J, Mitchell MJ. Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean. Eur J Hum Genet. 2011 Jan; 19(1):89-94. PMID: 20700146.
      View in: PubMed
    55. Chiaroni J, King RJ, Myres NM, Henn BM, Ducourneau A, Mitchell MJ, Boetsch G, Sheikha I, Lin AA, Nik-Ahd M, Ahmad J, Lattanzi F, Herrera RJ, Ibrahim ME, Brody A, Semino O, Kivisild T, Underhill PA. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 2010 Mar; 18(3):348-53. PMID: 19826455.
      View in: PubMed
    56. Mitchell MJ, Stubbs BA, Eisenberg MS. Socioeconomic status is associated with provision of bystander cardiopulmonary resuscitation. Prehosp Emerg Care. 2009 Oct-Dec; 13(4):478-86. PMID: 19731160.
      View in: PubMed
    57. Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG. Metakaryotic stem cell lineages in organogenesis of humans and other metazoans. Organogenesis. 2009 Oct; 5(4):191-200. PMID: 20539738.
      View in: PubMed
    58. Metzler-Guillemain C, Depetris D, Luciani JJ, Mignon-Ravix C, Mitchell MJ, Mattei MG. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008; 16(5):761-82. PMID: 18592385.
      View in: PubMed
    59. Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ. Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. Hum Mol Genet. 2008 Sep 15; 17(18):2803-18. PMID: 18562473.
      View in: PubMed
    60. Mitchell MJ, Montgomery M, Reiter CG, Culp WC. Pericardial tamponade following CT-guided lung biopsy. Cardiovasc Intervent Radiol. 2008 Jul; 31 Suppl 2:S227-30. PMID: 17962996.
      View in: PubMed
    61. Mitchell MJ, Dai L, Clarke JB, Bolton-Maggs PH, Savidge GF, Alhaq A. Characterisation of five factor XI mutations. Thromb Haemost. 2007 Jun; 97(6):884-9. PMID: 17549289.
      View in: PubMed
    62. Bolton-Maggs PH, Hay CR, Shanks D, Mitchell MJ, McVey JH. The importance of tissue factor source in the management of Factor VII deficiency. Thromb Haemost. 2007 Jan; 97(1):151-2. PMID: 17200783.
      View in: PubMed
    63. Mitchell M, Mountford R, Butler R, Alhaq A, Dai L, Savidge G, Bolton-Maggs PH. Spectrum of factor XI (F11) mutations in the UK population--116 index cases and 140 mutations. Hum Mutat. 2006 Aug; 27(8):829. PMID: 16835901.
      View in: PubMed
    64. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9. PMID: 16580996.
      View in: PubMed
    65. Perrin J, Metzler-Guillemain C, Karsenty G, Grillo JM, Mitchell MJ, Guichaoua MR. Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. Fertil Steril. 2006 Feb; 85(2):494.e5-8. PMID: 16595237.
      View in: PubMed
    66. Millrain M, Scott D, Addey C, Dewchand H, Ellis P, Ehrmann I, Mitchell M, Burgoyne P, Simpson E, Dyson J. Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. J Immunol. 2005 Dec 1; 175(11):7209-17. PMID: 16301625.
      View in: PubMed
    67. Lepretre AC, Patrat C, Mitchell M, Jouannet P, Bienvenu T. No partial DAZ deletions but frequent gene conversion events on the Y chromosome of fertile men. J Assist Reprod Genet. 2005 Apr; 22(4):141-8. PMID: 16021857.
      View in: PubMed
    68. Cutler JA, Patel R, Mitchell MJ, Savidge GF. The significance of published polymorphisms in 14 cases of mild factor VII deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):91-5. PMID: 15741795.
      View in: PubMed
    69. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency. Am J Med Genet A. 2004 Aug 15; 129A(1):13-5. PMID: 15266608.
      View in: PubMed
    70. Mitchell M, Dai L, Savidge G, Alhaq A. An Alu-mediated 31.5-kb deletion as the cause of factor XI deficiency in 2 unrelated patients. Blood. 2004 Oct 15; 104(8):2394-6. PMID: 15226185.
      View in: PubMed
    71. Dai L, Mitchell M, Carson P, Creagh D, Cutler J, Savidge G, Alhaq A. Severe factor XI deficiency caused by compound heterozygosity. Br J Haematol. 2004 Jun; 125(6):817-8. PMID: 15180874.
      View in: PubMed
    72. Cutler JA, Mitchell MJ, Savidge GF. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients. J Thromb Haemost. 2004 Jun; 2(6):1021. PMID: 15140150.
      View in: PubMed
    73. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56. PMID: 15241014.
      View in: PubMed
    74. Mitchell M, Harrington P, Cutler J, Rangarajan S, Savidge G, Alhaq A. Eighteen unrelated patients with factor XI deficiency, four novel mutations and a 100% detection rate by denaturing high-performance liquid chromatography. Br J Haematol. 2003 May; 121(3):500-2. PMID: 12716376.
      View in: PubMed
    75. Patel YM, Patel K, Rahman S, Smith MP, Spooner G, Sumathipala R, Mitchell M, Flynn G, Aitken A, Savidge G. Evidence for a role for Galphai1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Galphai1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder. Blood. 2003 Jun 15; 101(12):4828-35. PMID: 12609843.
      View in: PubMed
    76. Bagai S, Rubio E, Cheng JF, Sweet R, Thomas R, Fuchs E, Grady R, Mitchell M, Bassuk JA. Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem. 2002 Jun 28; 277(26):23828-37. PMID: 11923311.
      View in: PubMed
    77. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4. PMID: 11750690.
      View in: PubMed
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