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Jon D Goguen PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-2490
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBacterial Genetics and Pathogenesis


    Collapse Biography 
    Collapse education and training
    Fitchburg State College, Fitchburg, MA, United StatesBSBiology
    University of Massachusetts Amherst, Amherst, MA, United StatesMSZoology
    University of Massachusetts Amherst, Amherst, MA, United StatesPHDZoology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Palace SG, Vitseva O, Proulx MK, Freedman JE, Goguen JD, Koupenova M. Yersinia pestis escapes entrapment in thrombi by targeting platelet function. J Thromb Haemost. 2020 12; 18(12):3236-3248. PMID: 33470041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Pulsifer AR, Vashishta A, Reeves SA, Wolfe JK, Palace SG, Proulx MK, Goguen J, Bodduluri SR, Haribabu B, Uriarte SM, Lawrenz MB. Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach. Infect Immun. 2020 02 20; 88(3). PMID: 31871100.
      Citations: 3     Fields:    Translation:HumansCells
    3. Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 11 30; 362(6418):1064-1069. PMID: 30361383.
      Citations: 229     Fields:    Translation:HumansAnimalsCells
    4. Palace SG, Proulx MK, Szabady RL, Goguen JD. Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA. Infect Immun. 2018 09; 86(9). PMID: 29891548.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15; 2:17072. PMID: 28504669.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    6. Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathog. 2016 Dec; 12(12):e1006035. PMID: 27911947.
      Citations: 40     Fields:    Translation:AnimalsCells
    7. Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E. Manipulation of interleukin-1? and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence. J Biol Chem. 2016 07 29; 291(31):16417. PMID: 27474778.
      Citations: 4     Fields:    
    8. Proulx MK, Ellison RT, Goguen JD. Reply to Gelfand and Cleveland. J Infect Dis. 2016 May 15; 213(10):1671-2. PMID: 26962234.
      Citations:    Fields:    
    9. Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E. Manipulation of Interleukin-1? and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence. J Biol Chem. 2016 May 06; 291(19):9894-905. PMID: 26884330.
      Citations: 14     Fields:    Translation:AnimalsCells
    10. Proulx MK, Palace SG, Gandra S, Torres B, Weir S, Stiles T, Ellison RT, Goguen JD. Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia. J Infect Dis. 2016 Mar 15; 213(6):1041-8. PMID: 26503983.
      Citations: 10     Fields:    Translation:HumansCells
    11. Palace SG, Proulx MK, Lu S, Baker RE, Goguen JD. Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue. mBio. 2014 Aug 19; 5(4). PMID: 25139902.
      Citations: 41     Fields:    Translation:AnimalsCells
    12. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      Citations: 136     Fields:    Translation:AnimalsCells
    13. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012 Jul 27; 37(1):96-107. PMID: 22840842.
      Citations: 155     Fields:    Translation:AnimalsCells
    14. Wang S, Goguen JD, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011 Sep 09; 29(39):6802-9. PMID: 21199697.
      Citations: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Eren E, Murphy M, Goguen J, van den Berg B. An active site water network in the plasminogen activator pla from Yersinia pestis. Structure. 2010 Jul 14; 18(7):809-18. PMID: 20637417.
      Citations: 22     Fields:    Translation:Cells
    16. Wang S, Mboudjeka I, Goguen JD, Lu S. Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines. Vaccine. 2010 Feb 23; 28(8):2011-9. PMID: 20188257.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Hayward RD, Goguen JD, Leong JM. No better time to FRET: shedding light on host pathogen interactions. J Biol. 2010; 9(2):12. PMID: 20236488.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Pan NJ, Brady MJ, Leong JM, Goguen JD. Targeting type III secretion in Yersinia pestis. Antimicrob Agents Chemother. 2009 Feb; 53(2):385-92. PMID: 19015348.
      Citations: 34     Fields:    Translation:HumansCells
    19. Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008 Mar 20; 26(13):1664-74. PMID: 18291562.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Sweet CR, Conlon J, Golenbock DT, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007 Nov; 9(11):2700-15. PMID: 17608743.
      Citations: 66     Fields:    Translation:HumansCells
    21. Pouliot K, Pan N, Wang S, Lu S, Lien E, Goguen JD. Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis. Infect Immun. 2007 Jul; 75(7):3571-80. PMID: 17438030.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    22. Pan N, Lee C, Goguen J. High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis. Adv Exp Med Biol. 2007; 603:367-75. PMID: 17966433.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F, Conlon JE, Fukase K, Kusumoto S, Sweet C, Miyake K, Akira S, Cotter RJ, Goguen JD, Lien E. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol. 2006 Oct; 7(10):1066-73. PMID: 16980981.
      Citations: 196     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Ngampasutadol J, Ram S, Blom AM, Jarva H, Jerse AE, Lien E, Goguen J, Gulati S, Rice PA. Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17142-7. PMID: 16275906.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    25. Wang S, Heilman D, Liu F, Giehl T, Joshi S, Huang X, Chou TH, Goguen J, Lu S. A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague. Vaccine. 2004 Sep 03; 22(25-26):3348-57. PMID: 15308359.
      Citations: 47     Fields:    Translation:AnimalsCells
    26. Leong JM, Parveen N, Goguen JD. New approaches and old problems in the shadow of bioterrorism. Trends Microbiol. 2002 Mar; 10(3):112-4. PMID: 11864812.
      Citations:    Fields:    Translation:AnimalsCells
    27. Goguen JD, Bugge T, Degen JL. Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice. Methods. 2000 Jun; 21(2):179-83. PMID: 10816379.
      Citations: 17     Fields:    Translation:AnimalsCells
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