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Jon D Goguen PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-2490
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMolecular Genetics and Microbiology

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBacterial Genetics and Pathogenesis


    Collapse Biography 
    Collapse education and training
    Fitchburg State College, Fitchburg, MA, United StatesBSBiology
    University of Massachusetts Amherst, Amherst, MA, United StatesMSZoology
    University of Massachusetts Amherst, Amherst, MA, United StatesPHDZoology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 Oct 25. PMID: 30361383.
      View in: PubMed
    2. Palace SG, Proulx MK, Szabady RL, Goguen JD. Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA. Infect Immun. 2018 Sep; 86(9). PMID: 29891548.
      View in: PubMed
    3. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2017 May 15; 2:17072. PMID: 28504669.
      View in: PubMed
    4. Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS Pathog. 2016 Dec; 12(12):e1006035. PMID: 27911947.
      View in: PubMed
    5. Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E. Manipulation of interleukin-1ß and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence. J Biol Chem. 2016 Jul 29; 291(31):16417. PMID: 27474778.
      View in: PubMed
    6. Proulx MK, Ellison RT, Goguen JD. Reply to Gelfand and Cleveland. J Infect Dis. 2016 May 15; 213(10):1671-2. PMID: 26962234.
      View in: PubMed
    7. Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E. Manipulation of Interleukin-1ß and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence. J Biol Chem. 2016 May 06; 291(19):9894-905. PMID: 26884330.
      View in: PubMed
    8. Proulx MK, Palace SG, Gandra S, Torres B, Weir S, Stiles T, Ellison RT, Goguen JD. Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia. J Infect Dis. 2016 Mar 15; 213(6):1041-8. PMID: 26503983.
      View in: PubMed
    9. Palace SG, Proulx MK, Lu S, Baker RE, Goguen JD. Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue. MBio. 2014 Aug 19; 5(4). PMID: 25139902.
      View in: PubMed
    10. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      View in: PubMed
    11. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity. 2012 Jul 27; 37(1):96-107. PMID: 22840842.
      View in: PubMed
    12. Wang S, Goguen JD, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011 Sep 9; 29(39):6802-9. PMID: 21199697.
      View in: PubMed
    13. Eren E, Murphy M, Goguen J, van den Berg B. An active site water network in the plasminogen activator pla from Yersinia pestis. Structure. 2010 Jul 14; 18(7):809-18. PMID: 20637417.
      View in: PubMed
    14. Wang S, Mboudjeka I, Goguen JD, Lu S. Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines. Vaccine. 2010 Feb 23; 28(8):2011-9. PMID: 20188257.
      View in: PubMed
    15. Hayward RD, Goguen JD, Leong JM. No better time to FRET: shedding light on host pathogen interactions. J Biol. 2010; 9(2):12. PMID: 20236488.
      View in: PubMed
    16. Pan NJ, Brady MJ, Leong JM, Goguen JD. Targeting type III secretion in Yersinia pestis. Antimicrob Agents Chemother. 2009 Feb; 53(2):385-92. PMID: 19015348.
      View in: PubMed
    17. Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008 Mar 20; 26(13):1664-74. PMID: 18291562.
      View in: PubMed
    18. Sweet CR, Conlon J, Golenbock DT, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007 Nov; 9(11):2700-15. PMID: 17608743.
      View in: PubMed
    19. Pouliot K, Pan N, Wang S, Lu S, Lien E, Goguen JD. Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis. Infect Immun. 2007 Jul; 75(7):3571-80. PMID: 17438030.
      View in: PubMed
    20. Pan N, Lee C, Goguen J. High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis. Adv Exp Med Biol. 2007; 603:367-75. PMID: 17966433.
      View in: PubMed
    21. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F, Conlon JE, Fukase K, Kusumoto S, Sweet C, Miyake K, Akira S, Cotter RJ, Goguen JD, Lien E. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol. 2006 Oct; 7(10):1066-73. PMID: 16980981.
      View in: PubMed
    22. Ngampasutadol J, Ram S, Blom AM, Jarva H, Jerse AE, Lien E, Goguen J, Gulati S, Rice PA. Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17142-7. PMID: 16275906.
      View in: PubMed
    23. Wang S, Heilman D, Liu F, Giehl T, Joshi S, Huang X, Chou TH, Goguen J, Lu S. A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague. Vaccine. 2004 Sep 3; 22(25-26):3348-57. PMID: 15308359.
      View in: PubMed
    24. Leong JM, Parveen N, Goguen JD. New approaches and old problems in the shadow of bioterrorism. Trends Microbiol. 2002 Mar; 10(3):112-4. PMID: 11864812.
      View in: PubMed
    25. Goguen JD, Bugge T, Degen JL. Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice. Methods. 2000 Jun; 21(2):179-83. PMID: 10816379.
      View in: PubMed
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