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Jane E. Freedman MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CT, United StatesBALiberal Arts
    Tufts University, Medford, MA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Koupenova M, Freedman JE. Platelets and Immunity: Going Viral. Arterioscler Thromb Vasc Biol. 2020 Jul; 40(7):1605-1607. PMID: 32579477.
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    2. Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019 Aug 24; 19:916-926. PMID: 31518900.
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    3. Tran KV, Majka J, Sanghai S, Sardana M, Lessard D, Milstone Z, Tanriverdi K, Freedman JE, Fitzgibbons TP, McManus D. Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study. Front Cardiovasc Med. 2019; 6:115. PMID: 31475159.
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    4. Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. PLoS One. 2019; 14(8):e0219261. PMID: 31393881.
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    5. Huan T, Mendelson M, Joehanes R, Yao C, Liu C, Song C, Bhattacharya A, Rong J, Tanriverdi K, Keefe J, Murabito JM, Courchesne P, Larson MG, Freedman JE, Levy D. Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits. Epigenetics. 2019 Jul 06. PMID: 31282290.
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    6. Freedman JE. Circulation Research. Circ Res. 2019 Jun 21; 125(1):5-6. PMID: 31219737.
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    7. Tran KV, Tanriverdi K, Aurigemma GP, Lessard D, Sardana M, Parker M, Shaikh A, Gottbrecht M, Milstone Z, Tanriverdi S, Vitseva O, Keaney JF, Kiefe CI, McManus DD, Freedman JE. Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome. J Clin Transl Res. 2019 Sep 08; 5(1):33-43. PMID: 31579840.
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    8. Freedman JE, Trivedi CM. The Adverse Vascular Effects of E-Cigarettes: Smoke Without the Fire. J Am Coll Cardiol. 2019 Jun 04; 73(21):2738-2739. PMID: 31146819.
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    9. McAnena P, Tanriverdi K, Curran C, Gilligan K, Freedman JE, Brown JAL, Kerin MJ. Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer. BMC Cancer. 2019 May 10; 19(1):436. PMID: 31077182.
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    10. Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019 Apr 16; 10(1):1780. PMID: 30992428.
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    11. Shah R, Murthy V, Freedman JE. Nuts, Cardiovascular Health, and Diabetes. Circ Res. 2019 Mar 15; 124(6):825-826. PMID: 30870120.
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    12. Shah RV, Hwang SJ, Yeri A, Tanriverdi K, Pico AR, Yao C, Murthy V, Ho J, Vitseva O, Demarco D, Shah S, Iafrati MD, Levy D, Freedman JE. Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. Arterioscler Thromb Vasc Biol. 2019 Jan; 39(1):107-115. PMID: 30580566.
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    13. Shah R, Patel T, Freedman JE. Circulating Extracellular Vesicles in Human Disease. N Engl J Med. 2018 11 29; 379(22):2180-2181. PMID: 30485772.
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    14. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 Sep 06; 36(9):899. PMID: 30188530.
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    15. Shah R, Patel T, Freedman JE. Circulating Extracellular Vesicles in Human Disease. N Engl J Med. 2018 09 06; 379(10):958-966. PMID: 30184457.
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    16. Narla V, Bhakta N, Freedman JE, Tanriverdi K, Maka K, Deeks SG, Ganz P, Hsue P. Unique Circulating MicroRNA profiles in HIV Infection. J Acquir Immune Defic Syndr. 2018 Sep 04. PMID: 30204717.
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    17. Shah RV, Rong J, Larson MG, Yeri A, Ziegler O, Tanriverdi K, Murthy V, Liu X, Xiao C, Pico AR, Huan T, Levy D, Lewis GD, Rosenzweig A, Vasan RS, Das S, Freedman JE. Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure. JAMA Cardiol. 2018 Aug 08. PMID: 30090932.
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    18. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 Sep; 36(8):746-757. PMID: 30010675.
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    19. Danielson KM, Shah R, Yeri A, Liu X, Camacho Garcia F, Silverman M, Tanriverdi K, Das A, Xiao C, Jerosch-Herold M, Heydari B, Abbasi S, Van Keuren-Jensen K, Freedman JE, Wang YE, Rosenzweig A, Kwong RY, Das S. Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction. EBioMedicine. 2018 May 17. PMID: 29779700.
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    20. Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE. Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population. Sci Rep. 2018 Apr 23; 8(1):6397. PMID: 29686252.
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    21. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res. 2018 Jan 19; 122(2):337-351. PMID: 29348254.
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    22. Shah RV, Yeri AS, Murthy VL, Massaro JM, D'Agostino R, Freedman JE, Long MT, Fox CS, Das S, Benjamin EJ, Vasan RS, O'Donnell CJ, Hoffmann U. Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes: The Framingham Heart Study. JAMA Cardiol. 2017 Nov 01; 2(11):1236-1246. PMID: 28975197.
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    23. Huan T, Chen G, Liu C, Bhattacharya A, Rong J, Chen BH, Seshadri S, Tanriverdi K, Freedman JE, Larson MG, Murabito JM, Levy D. Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell. 2018 Feb; 17(1). PMID: 29044988.
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    24. Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 29030400.
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    25. Shah R, Yeri A, Das A, Courtright-Lim A, Ziegler O, Gervino E, Ocel J, Quintero-Pinzon P, Wooster L, Bailey CS, Tanriverdi K, Beaulieu LM, Freedman JE, Ghiran I, Lewis GD, Van Keuren-Jensen K, Das S. Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: brief report. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1162-H1167. PMID: 28916639.
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    26. Liaw L, Freedman JE, Becker LB, Mehta NN, Liscum L. Peer Review Practices for Evaluating Biomedical Research Grants: A Scientific Statement From the American Heart Association. Circ Res. 2017 Aug 04; 121(4):e9-e19. PMID: 28684631.
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    27. Murabito JM, Rong J, Lunetta KL, Huan T, Lin H, Zhao Q, Freedman JE, Tanriverdi K, Levy D, Larson MG. Cross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample. Aging Cell. 2017 Jun 08. PMID: 28597569.
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    28. Yao C, Joehanes R, Johnson AD, Huan T, Liu C, Freedman JE, Munson PJ, Hill DE, Vidal M, Levy D. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017 Jun 01; 100(6):985-986. PMID: 28575653.
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    29. Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK. Decreased Thromboembolic Stroke but not Atherosclerosis or Vascular Remodeling in Mice with ROCK2-deficient Platelets. Cardiovasc Res. 2017 Apr 14. PMID: 28430966.
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    30. Shah RV, Spahillari A, Mwasongwe S, Carr JJ, Terry JG, Mentz RJ, Addison D, Hoffmann U, Reis J, Freedman JE, Lima JA, Correa A, Murthy VL. Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study. JAMA Cardiol. 2017 Mar 18. PMID: 28315622.
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    31. Mick E, Shah R, Tanriverdi K, Murthy V, Gerstein M, Rozowsky J, Kitchen R, Larson MG, Levy D, Freedman JE. Stroke and Circulating Extracellular RNAs. Stroke. 2017 Mar 13. PMID: 28289238.
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    32. Clancy L, Beaulieu LM, Tanriverdi K, Freedman JE. The role of RNA uptake in platelet heterogeneity. Thromb Haemost. 2017 Mar 09. PMID: 28276570.
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    33. Yao C, Joehanes R, Johnson AD, Huan T, Liu C, Freedman JE, Munson PJ, Hill DE, Vidal M, Levy D. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017 Mar 08. PMID: 28285768.
      View in: PubMed
    34. Shah R, Murthy V, Pacold M, Danielson K, Tanriverdi K, Larson MG, Hanspers K, Pico A, Mick E, Reis J, de Ferranti S, Freinkman E, Levy D, Hoffmann U, Osganian S, Das S, Freedman JE. Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes. Diabetes Care. 2017 Feb 09. PMID: 28183786.
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    35. McManus DD, Rong J, Huan T, Lacey S, Tanriverdi K, Munson PJ, Larson MG, Joehanes R, Murthy V, Shah R, Freedman JE, Levy D. Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors. BMC Genomics. 2017 Feb 08; 18(1):139. PMID: 28178938.
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    36. Spahillari A, Talegawkar S, Correa A, Carr JJ, Terry JG, Lima J, Freedman JE, Das S, Kociol R, de Ferranti S, Mohebali D, Mwasongwe S, Tucker KL, Murthy VL, Shah RV. Ideal Cardiovascular Health, Cardiovascular Remodeling, and Heart Failure in Blacks: The Jackson Heart Study. Circ Heart Fail. 2017 Feb; 10(2). PMID: 28209767.
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    37. Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Schäffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ. Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies. Genome Biol. 2017 Jan 25; 18(1):16. PMID: 28122634.
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    38. Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2016 Dec 30. PMID: 28039338.
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    39. Freedman JE, Miano JM. Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan; 37(1):21-25. PMID: 27856459.
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    40. Shah R, Pico AR, Freedman JE. Translational Epidemiology: Entering a Brave New World of Team Science. Circ Res. 2016 Oct 28; 119(10):1060-1062. PMID: 27789584.
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    41. Murthy VL, Abbasi SA, Siddique J, Colangelo LA, Reis J, Venkatesh BA, Carr JJ, Terry JG, Camhi SM, Jerosch-Herold M, de Ferranti S, Das S, Freedman J, Carnethon MR, Lewis CE, Lima JA, Shah RV. Transitions in Metabolic Risk and Long-Term Cardiovascular Health: Coronary Artery Risk Development in Young Adults (CARDIA) Study. J Am Heart Assoc. 2016 Oct 13; 5(10). PMID: 27737876.
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    42. Barik A, Shah RV, Spahillari A, Murthy VL, Ambale-Venkatesh B, Rai RK, Das K, Santra A, Hembram JR, Bhattacharya D, Freedman JE, Lima J, Das R, Bhattacharyya P, Das S, Chowdhury A. Hepatic steatosis is associated with cardiometabolic risk in a rural Indian population: A prospective cohort study. Int J Cardiol. 2016 Dec 15; 225:161-166. PMID: 27723535.
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    43. Das A, Ambale-Venkatesh B, Lima JA, Freedman JE, Spahillari A, Das R, Das S, Shah RV, Murthy VL. Cardiometabolic disease in South Asians: A global health concern in an expanding population. Nutr Metab Cardiovasc Dis. 2017 Jan; 27(1):32-40. PMID: 27612985.
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    44. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova M, Mikhalev E, Tanriverdi K. Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016; 7:11902. PMID: 27255613.
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    45. Shah R, Tanriverdi K, Levy D, Larson M, Gerstein M, Mick E, Rozowsky J, Kitchen R, Murthy V, Mikalev E, Freedman JE. Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources. PLoS One. 2016; 11(4):e0153691. PMID: 27123852.
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    46. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova-Zamor M, Mikhalev E, Tanriverdi K. Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016 Apr 26; 7:11106. PMID: 27112789.
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    47. Tanriverdi K, Kucukural A, Mikhalev E, Tanriverdi SE, Lee R, Ambros VR, Freedman JE. Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction. Anal Biochem. 2016 May 15; 501:66-74. PMID: 26969789.
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    48. Beaulieu LM, Vitseva O, Tanriverdi K, Kucukural A, Mick E, Hamburg N, Vita J, Freedman JE. Platelet functional and transcriptional changes induced by intralipid infusion. Thromb Haemost. 2016 Jun 2; 115(6):1147-56. PMID: 26940969.
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    49. Clancy L, Freedman JE. Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle. Circ Res. 2016 Feb 5; 118(3):374-6. PMID: 26846635.
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    50. Eicher JD, Wakabayashi Y, Vitseva O, Esa N, Yang Y, Zhu J, Freedman JE, McManus DD, Johnson AD. Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets. 2016; 27(3):230-9. PMID: 26367242.
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    51. Quinn JF, Patel T, Wong D, Das S, Freedman JE, Laurent LC, Carter BS, Hochberg F, Van Keuren-Jensen K, Huentelman M, Spetzler R, Kalani MY, Arango J, Adelson PD, Weiner HL, Gandhi R, Goilav B, Putterman C, Saugstad JA. Extracellular RNAs: development as biomarkers of human disease. J Extracell Vesicles. 2015; 4:27495. PMID: 26320940.
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    52. Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937.
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    53. McManus DD, Freedman JE. MicroRNAs in platelet function and cardiovascular disease. Nat Rev Cardiol. 2015 Dec; 12(12):711-7. PMID: 26149483.
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    54. Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One. 2015; 10(7):e0131688. PMID: 26148065.
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    55. Clancy L, Freedman JE. The role of circulating platelet transcripts. J Thromb Haemost. 2015 Jun; 13 Suppl 1:S33-9. PMID: 26149043.
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    56. Huan T, Rong J, Liu C, Zhang X, Tanriverdi K, Joehanes R, Chen BH, Murabito JM, Yao C, Courchesne P, Munson PJ, O'Donnell CJ, Cox N, Johnson AD, Larson MG, Levy D, Freedman JE. Genome-wide identification of microRNA expression quantitative trait loci. Nat Commun. 2015 Mar 20; 6:6601. PMID: 25791433.
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    57. Huan T, Rong J, Tanriverdi K, Meng Q, Bhattacharya A, McManus DD, Joehanes R, Assimes TL, McPherson R, Samani NJ, Erdmann J, Schunkert H, Courchesne P, Munson PJ, Johnson AD, O'Donnell CJ, Zhang B, Larson MG, Freedman JE, Levy D, Yang X. Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1011-21. PMID: 25657313.
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    58. Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1030-7. PMID: 25657311.
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    59. Koupenova M, Freedman JE. Platelets: the unsung hero of the immune response. J Thromb Haemost. 2015 Feb; 13(2):268-70. PMID: 25471925.
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    60. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014 Dec 24; 15:1176. PMID: 25540039.
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    61. Yao C, Chen BH, Joehanes R, Otlu B, Zhang X, Liu C, Huan T, Tastan O, Cupples LA, Meigs JB, Fox CS, Freedman JE, Courchesne P, O'Donnell CJ, Munson PJ, Keles S, Levy D. Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes. Circulation. 2015 Feb 10; 131(6):536-49. PMID: 25533967.
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    62. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF, Donahue JK, Benjamin EJ, Freedman JE. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015 Jan; 12(1):3-10. PMID: 25257092.
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    63. Freedman JE, Gersh BJ. Atrial fibrillation and stroke prevention in aging patients: what's good can be even better. Circulation. 2014 Jul 8; 130(2):129-31. PMID: 24895453.
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    64. Freedman JE. Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease. Circ Res. 2014 Apr 25; 114(9):1372-3. PMID: 24763461.
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    65. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014 Jul 31; 124(5):791-802. PMID: 24755410.
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    66. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1ß regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64. PMID: 24458711.
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    67. McManus DD, Lin H, Tanriverdi K, Quercio M, Yin X, Larson MG, Ellinor PT, Levy D, Freedman JE, Benjamin EJ. Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study. Heart Rhythm. 2014 Apr; 11(4):663-9. PMID: 24444445.
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    68. Clancy L, Freedman JE. New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. J Thromb Thrombolysis. 2014 Jan; 37(1):12-6. PMID: 24163053.
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    69. Yao C, Joehanes R, Johnson AD, Huan T, Esko T, Ying S, Freedman JE, Murabito J, Lunetta KL, Metspalu A, Munson PJ, Levy D. Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet. 2014 Apr 1; 23(7):1947-56. PMID: 24242183.
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    70. Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD. Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction. Fam Med Med Sci Res. 2013 Oct 1; 2(2):108. PMID: 24432306.
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    71. Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet. 2014 Feb 1; 23(3):782-95. PMID: 24057673.
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    72. McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73. PMID: 23968978.
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    73. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. PMID: 23867623.
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    74. Freedman JE, Tanriverdi K. Defining miRNA targets: balancing simplicity with complexity. Circulation. 2013 May 28; 127(21):2075-7. PMID: 23625958.
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    75. Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ. Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1418-26. PMID: 23539218.
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    76. Johnson AD, Hwang SJ, Voorman A, Morrison A, Peloso GM, Hsu YH, Thanassoulis G, Newton-Cheh C, Rogers IS, Hoffmann U, Freedman JE, Fox CS, Psaty BM, Boerwinkle E, Cupples LA, O'Donnell CJ. Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation. 2013 Feb 19; 127(7):799-810. PMID: 23315372.
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    77. Freedman JE, Ercan B, Morin KM, Liu CT, Tamer L, Ayaz L, Kanadasi M, Cicek D, Seyhan AI, Akilli RE, Camci C, Cengiz B, Oztuzcu S, Tanriverdi K. The distribution of circulating microRNA and their relation to coronary disease. F1000Res. 2012; 1:50. PMID: 24358814.
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    83. Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE, Joseph L, Hess DT, Apovian CM, Vita JA, Gokce N. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol. 2011 Jul 12; 58(3):232-7. PMID: 21737012.
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    84. Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011 Jun 2; 117(22):5963-74. PMID: 21454454.
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    85. Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Stone JH, Freedman JE, Merkel PA. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011 Jun; 38(6):1048-54. PMID: 21411717.
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    86. Gersh BJ, Freedman JE, Granger CB. [Antiplatelet and anticoagulant therapy for stroke prevention in patients with non-valvular atrial fibrillation: evidence based strategies and new developments]. Rev Esp Cardiol. 2011 Apr; 64(4):260-8. PMID: 21411211.
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    87. Freedman JE, Vitseva O, Tanriverdi K. The role of the blood transcriptome in innate inflammation and stroke. Ann N Y Acad Sci. 2010 Oct; 1207:41-5. PMID: 20955424.
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    88. Freedman JE, Iafrati HF. Use of genetics and transcriptomics in the diagnosis and treatment of coronary artery disease. Rev Esp Cardiol. 2010 Oct; 63(10):1123-6. PMID: 20875351.
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    89. Cohen LB, Sanyal SM, Von Althann C, Bodian C, Whitson M, Bamji N, Miller KM, Mavronicolas W, Burd S, Freedman J, Aisenberg J. Clinical trial: 2-L polyethylene glycol-based lavage solutions for colonoscopy preparation - a randomized, single-blind study of two formulations. Aliment Pharmacol Ther. 2010 Sep; 32(5):637-44. PMID: 20626383.
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    90. Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation. 2010 Jul 13; 122(2):119-29. PMID: 20606121.
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    91. Chakrabarti S, Freedman JE. Review: Nutriceuticals as antithrombotic agents. Cardiovasc Ther. 2010 Aug; 28(4):227-35. PMID: 20553290.
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    92. Marsk R, Näslund E, Freedman J, Tynelius P, Rasmussen F. Bariatric surgery reduces mortality in Swedish men. Br J Surg. 2010 Jun; 97(6):877-83. PMID: 20309894.
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    93. Chakrabarti S, Rizvi M, Morin K, Garg R, Freedman JE. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):130-7. PMID: 20546942.
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    94. Beaulieu LM, Freedman JE. p38: signaling improved platelet storage? Blood. 2010 Mar 4; 115(9):1665-6. PMID: 20203272.
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    95. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27. PMID: 20102488.
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    96. Beaulieu LM, Freedman JE. The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes. Thromb Res. 2010 Mar; 125(3):205-9. PMID: 19945154.
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    97. Chakrabarti S, Beaulieu LM, Reyelt LA, Iafrati MD, Freedman JE. M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice. J Thromb Thrombolysis. 2009 Nov; 28(4):394-400. PMID: 19399370.
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    98. Freedman JE, Gersh BJ. New therapies for stroke prevention in atrial fibrillation: the long road to enhanced efficacy. Circulation. 2009 Sep 22; 120(12):1024-6. PMID: 19738132.
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    99. Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110. PMID: 19572074.
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    100. Beaulieu LM, Freedman JE. NFkappaB regulation of platelet function: no nucleus, no genes, no problem? J Thromb Haemost. 2009 Aug; 7(8):1329-32. PMID: 19500240.
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    101. Faxon DP, Freedman JE. Facts and controversies of aspirin and clopidogrel therapy. Am Heart J. 2009 Mar; 157(3):412-22. PMID: 19249409.
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    102. Chakrabarti S, Rizvi M, Pathak D, Kirber MT, Freedman JE. Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. Immunol Lett. 2009 Feb 21; 122(2):170-84. PMID: 19187784.
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    103. Freedman JE, Hylek EM. Clopidogrel, genetics, and drug responsiveness. N Engl J Med. 2009 Jan 22; 360(4):411-3. PMID: 19164193.
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    104. Lin E, Freedman JE, Beaulieu LM. Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases. Cardiovasc Ther. 2009; 27(2):117-23. PMID: 19426249.
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    105. Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54. PMID: 19106411.
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    106. Rizvi M, Pathak D, Freedman JE, Chakrabarti S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med. 2008 Dec; 14(12):530-8. PMID: 18977174.
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    107. Keaney JF, Lipinska I, Larson MG, Dupuis J, Freedman JE, Hamburg NM, Massaro JM, Rong J, Sutherland P, Vita JA, Vasan RS, Benjamin EJ. Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J. 2008 Nov; 156(5):1003-1009.e1. PMID: 19061720.
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    108. Tanriverdi K, Freedman JE. Blood and cardiovascular disease: the promise and limitations of gene expression analysis. Circ Cardiovasc Genet. 2008 Oct; 1(1):7-9. PMID: 20031537.
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    109. Kleiman NS, Freedman JE, Tracy PB, Furie BC, Bray PF, Rao SV, Phillips DR, Storey RF, Rusconi CP, French PA, Steinhubl SR, Becker RC. Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development. Platelets. 2008 Jun; 19(4):239-51. PMID: 18569859.
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    110. Ector H, Lancellotti P, Roberts WC, Wenger NK, Moss AJ, Smith ER, Borer JS, Eagle KA, Freedman J, Krum H, Lang C, Remme WJ, Piper HM, White CJ, Loscalzo J, Marbán E, Sobel BE, Roberts R, Rahimtoola SH, Camm AJ, Van de Werf F, Swedberg K, Timmis AD, Stone KS, Zipes DP, Iosselani DG, Taylor AJ, Rosen MR, Grines CL, DeMaria AN, Narula J, King SB, Wagner GS, Saksena S, Pearlman AS, Bodnar E, Emery RW, Cohn LH, van der Wall EE, Abdulla RI, Lesch M, Alfonso F, Ekroth R. A statement on ethics from the HEART Group. JACC Cardiovasc Imaging. 2008 May; 1(3):410-2. PMID: 19356460.
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    111. Blair P, Freedman JE. Aspirin resistance in atherosclerosis. Curr Atheroscler Rep. 2008 Apr; 10(2):149-57. PMID: 18417070.
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    112. Vanichakarn P, Blair P, Wu C, Freedman JE, Chakrabarti S. Neutrophil CD40 enhances platelet-mediated inflammation. Thromb Res. 2008; 122(3):346-58. PMID: 18289643.
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    113. Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring). 2008 May; 16(5):932-7. PMID: 18292749.
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    114. Chakrabarti S, Freedman JE. Dipyridamole, cerebrovascular disease, and the vasculature. Vascul Pharmacol. 2008 Apr-Jun; 48(4-6):143-9. PMID: 18342579.
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    115. Freedman JE. Oxidative stress and platelets. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s11-6. PMID: 18174453.
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    116. Freedman JE. Promoting ethical conduct in the publication of research. Cardiovasc Ther. 2008; 26(2):89-90. PMID: 18485131.
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    117. Freedman JE. Transcriptomics: new targets for diagnosing and treating cardiovascular disease. Cardiovasc Ther. 2008; 26(3):179-81. PMID: 18786087.
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    118. Mutlu A, Allen DJ, Freedman J, Leytin V. The level of matrix metalloproteinase-2 in donor plasma strongly correlates with post-transfusion recovery of stored platelet concentrates. Vox Sang. 2008 Feb; 94(2):143-5. PMID: 18028261.
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    119. Chakrabarti S, Blair P, Wu C, Freedman JE. Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects. J Cardiovasc Pharmacol. 2007 Oct; 50(4):449-57. PMID: 18049314.
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    120. Freedman JE. Heritability, platelet function, and aspirin: a link established but cause unknown. Circulation. 2007 May 15; 115(19):2468-70. PMID: 17502587.
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    121. Chakrabarti S, Blair P, Freedman JE. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007 Jun 22; 282(25):18307-17. PMID: 17459878.
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    122. Leytin V, Allen DJ, Lyubimov E, Freedman J. Higher thrombin concentrations are required to induce platelet apoptosis than to induce platelet activation. Br J Haematol. 2007 Mar; 136(5):762-4. PMID: 17313379.
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    123. Leung R, Gwozdz AM, Wang H, Bang KW, Packham MA, Freedman J, Rand ML. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost. 2007 Mar; 5(3):560-70. PMID: 17155950.
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    124. Schmugge M, Bang KW, Blanchette VS, Albisetti M, Connolly BL, Freedman J, Rand ML. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol. 2007; 117(3):145-8. PMID: 17159336.
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    125. Tziros C, Freedman JE. The many antithrombotic actions of nitric oxide. Curr Drug Targets. 2006 Oct; 7(10):1243-51. PMID: 17073585.
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    126. Leytin V, Allen DJ, Mykhaylov S, Lyubimov E, Freedman J. Thrombin-triggered platelet apoptosis. J Thromb Haemost. 2006 Dec; 4(12):2656-63. PMID: 16961585.
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    127. Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006 Oct; 4(10):2230-7. PMID: 16824188.
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    128. Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost. 2006 Jul; 4(7):1621-3. PMID: 16839364.
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    129. Freedman JE. The aspirin resistance controversy: clinical entity or platelet heterogeneity? Circulation. 2006 Jun 27; 113(25):2865-7. PMID: 16801473.
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    130. Freedman JE. Resistance training: does it alter lytic potential? J Cardiopulm Rehabil. 2006 Mar-Apr; 26(2):84-5. PMID: 16569975.
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    131. Freedman JE. Molecular regulation of platelet-dependent thrombosis. Circulation. 2005 Oct 25; 112(17):2725-34. PMID: 16246969.
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    132. Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005 Oct; 46(4):445-51. PMID: 16160595.
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    133. Mason PJ, Jacobs AK, Freedman JE. Aspirin resistance and atherothrombotic disease. J Am Coll Cardiol. 2005 Sep 20; 46(6):986-93. PMID: 16168280.
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    134. Mason PJ, Chakrabarti S, Albers AA, Rex S, Vitseva O, Varghese S, Freedman JE. Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease. Am J Cardiol. 2005 Nov 15; 96(10):1365-9. PMID: 16275179.
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    135. Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE. CD40 ligand influences platelet release of reactive oxygen intermediates. Arterioscler Thromb Vasc Biol. 2005 Nov; 25(11):2428-34. PMID: 16141403.
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    136. Pallikadavath S, Garda L, Apte H, Freedman J, Stones RW. HIV/AIDS in rural India: context and health care needs. J Biosoc Sci. 2005 Sep; 37(5):641-55. PMID: 16174351.
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    137. Chakrabarti S, Vitseva O, Iyu D, Varghese S, Freedman JE. The effect of dipyridamole on vascular cell-derived reactive oxygen species. J Pharmacol Exp Ther. 2005 Nov; 315(2):494-500. PMID: 16046616.
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    138. Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, Freedman J, Ni H. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost. 2005 May; 3(5):875-83. PMID: 15733060.
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    139. Iafrati MD, Vitseva O, Tanriverdi K, Blair P, Rex S, Chakrabarti S, Varghese S, Freedman JE. Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1627-32. PMID: 15563534.
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    140. Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JE. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):e179-80. PMID: 15528483.
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    141. Vitseva O, Flockhart DA, Jin Y, Varghese S, Freedman JE. The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates. J Pharmacol Exp Ther. 2005 Mar; 312(3):1144-50. PMID: 15509721.
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    142. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 1: fundamentals of study design. Circulation. 2004 Jun 1; 109(21):e302-4. PMID: 15173052.
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    143. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting. Circulation. 2004 Jun 1; 109(21):2672-9. PMID: 15173050.
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    144. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 2: statistical concepts in study design and analysis. Circulation. 2004 Jun 1; 109(21):e305-7. PMID: 15173053.
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    145. Rand ML, Wang H, Bang KW, Poon KS, Packham MA, Freedman J. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost. 2004 Apr; 2(4):651-9. PMID: 15102022.
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    146. Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther. 2004 Jan; 75(1):60-9. PMID: 14749692.
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    147. Chakrabarti S, Clutton P, Varghese S, Cox D, Mascelli MA, Freedman JE. Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release. Thromb Res. 2004; 113(3-4):225-33. PMID: 15140587.
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    148. Mason PJ, Freedman JE, Jacobs AK. Aspirin resistance: current concepts. Rev Cardiovasc Med. 2004; 5(3):156-63. PMID: 15346099.
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    149. Clutton P, Miermont A, Freedman JE. Regulation of endogenous reactive oxygen species in platelets can reverse aggregation. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):187-92. PMID: 14604832.
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    150. Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost. 2003 Jun; 1(6):1183-8. PMID: 12871317.
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    151. Freedman JE. High-fat diets and cardiovascular disease: are nutritional supplements useful? J Am Coll Cardiol. 2003 May 21; 41(10):1750-2. PMID: 12767659.
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    152. Freedman JE. CD40-CD40L and platelet function: beyond hemostasis. Circ Res. 2003 May 16; 92(9):944-6. PMID: 12750303.
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    153. Freedman JE. CD40 ligand--assessing risk instead of damage? N Engl J Med. 2003 Mar 20; 348(12):1163-5. PMID: 12646674.
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    154. Freedman JE, Becker RC, Adams JE, Borzak S, Jesse RL, Newby LK, O'Gara P, Pezzullo JC, Kerber R, Coleman B, Broderick J, Yasuda S, Cannon C. Medication errors in acute cardiac care: An American Heart Association scientific statement from the Council on Clinical Cardiology Subcommittee on Acute Cardiac Care, Council on Cardiopulmonary and Critical Care, Council on Cardiovascular Nursing, and Council on Stroke. Circulation. 2002 Nov 12; 106(20):2623-9. PMID: 12427661.
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    155. Freedman JE. Nitrated lipids: defining their bioactivity. Circ Res. 2002 Sep 6; 91(5):371-2. PMID: 12215483.
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    156. Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, Freedman JE. Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics. 2002 Jul; 12(5):407-13. PMID: 12142730.
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    157. Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002 May 7; 105(18):2130-2. PMID: 11994242.
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    158. Abernethy DR, Pezzullo J, Mascelli MA, Frederick B, Kleiman NS, Freedman J. Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects. Clin Pharmacol Ther. 2002 Mar; 71(3):186-95. PMID: 11907493.
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    159. Rand ML, Wang H, Mody M, Chu I, Treutiger I, Nguyen A, Packham MA, Freedman J. Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin. Cytometry. 2002 Feb 1; 47(2):111-7. PMID: 11813201.
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    160. Freedman J, Mascelli MA, Pezzullo JC, Barnathan ES, Frederick B, Jordan RE, Abernethy DR. Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects. Am Heart J. 2002 Jan; 143(1):87-94. PMID: 11773917.
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    161. Freedman JE. Antioxidant versus lipid-altering therapy--some answers, more questions. N Engl J Med. 2001 Nov 29; 345(22):1636-7. PMID: 11757512.
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    162. Clutton P, Folts JD, Freedman JE. Pharmacological control of platelet function. Pharmacol Res. 2001 Oct; 44(4):255-64. PMID: 11592859.
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    163. Freedman JE, Parker C, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001 Jun 12; 103(23):2792-8. PMID: 11401934.
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    164. Parker C, Vita JA, Freedman JE. Soluble adhesion molecules and unstable coronary artery disease. Atherosclerosis. 2001 Jun; 156(2):417-24. PMID: 11395039.
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    165. Freedman JE. Thrombin, thrombomodulin, and extracellular signal-regulated kinases regulating cellular proliferation. Circ Res. 2001 Apr 13; 88(7):651-3. PMID: 11304485.
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    166. Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide. J Cardiovasc Pharmacol Ther. 2001 Apr; 6(2):163-73. PMID: 11509923.
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    167. Laupacis A, Brown J, Costello B, Delage G, Freedman J, Hume H, King S, Kleinman S, Mazzulli T, Wells G. Prevention of posttransfusion CMV in the era of universal WBC reduction: a consensus statement. Transfusion. 2001 Apr; 41(4):560-9. PMID: 11316911.
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    168. Freedman JE, Keaney JF. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J Nutr. 2001 Feb; 131(2):374S-7S. PMID: 11160564.
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    169. Freedman JE, Li L, Sauter R, Keaney JF JR. alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J. 2000 Dec; 14(15):2377-9. PMID: 11024007.
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    170. Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Quantification of platelet activation status by analyzing P-selectin expression. Biochem Biophys Res Commun. 2000 Jul 5; 273(2):565-70. PMID: 10873646.
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    171. Song S, Freedman J, Mody M, Lazarus AH. Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets. Br J Haematol. 2000 Jun; 109(4):851-6. PMID: 10929041.
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    172. Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations. Biochem Biophys Res Commun. 2000 Mar 5; 269(1):85-90. PMID: 10694482.
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    173. Bang KW, Speck ER, Blanchette VS, Freedman J, Semple JW. Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens. Blood. 2000 Mar 1; 95(5):1735-42. PMID: 10688832.
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    174. Loscalzo J, Freedman J, Inbal A, Keaney JF, Michelson AD, Vita JA. Nitric oxide insufficiency and arterial thrombosis. Trans Am Clin Climatol Assoc. 2000; 111:158-63. PMID: 10881340.
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    175. Kenet G, Freedman J, Shenkman B, Regina E, Brok-Simoni F, Holzman F, Vavva F, Brand N, Michelson A, Trolliet M, Loscalzo J, Inbal A. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):2017-23. PMID: 10446087.
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    176. Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res. 1999 Jun 25; 84(12):1416-21. PMID: 10381894.
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    177. Mody M, Lazarus AH, Semple JW, Freedman J. Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant. Transfus Med. 1999 Jun; 9(2):147-54. PMID: 10354385.
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    178. Keaney JF, Simon DI, Freedman JE. Vitamin E and vascular homeostasis: implications for atherosclerosis. FASEB J. 1999 Jun; 13(9):965-75. PMID: 10336880.
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    179. Lieberthal W, Fuhro R, Freedman JE, Toolan G, Loscalzo J, Valeri CR. O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J Pharmacol Exp Ther. 1999 Mar; 288(3):1278-87. PMID: 10027869.
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    180. Semple JW, Speck ER, Cosgrave D, Lazarus AH, Blanchette VS, Freedman J. Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity. Blood. 1999 Jan 15; 93(2):713-20. PMID: 9885234.
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    181. Freedman JE, Keaney JF. Nitric oxide and superoxide detection in human platelets. Methods Enzymol. 1999; 301:61-70. PMID: 9919554.
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    182. Ofosu FA, Freedman J, Dewar L, Song Y, Fenton JW. A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation. Biochem J. 1998 Dec 1; 336 ( Pt 2):283-5. PMID: 9820801.
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    183. Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 1998 Oct 13; 98(15):1481-6. PMID: 9769300.
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    184. Saxon BR, Mody M, Blanchette VS, Freedman J. Reticulated platelet counts in the assessment of thrombocytopenic disorders. Acta Paediatr Suppl. 1998 Jun; 424:65-70. PMID: 9736223.
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    185. Vita JA, Keaney JF, Raby KE, Morrow JD, Freedman JE, Lynch S, Koulouris SN, Hankin BR, Frei B. Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome. J Am Coll Cardiol. 1998 Apr; 31(5):980-6. PMID: 9561997.
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    186. Liu Z, Rudd MA, Freedman JE, Loscalzo J. S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther. 1998 Feb; 284(2):526-34. PMID: 9454793.
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    187. Lehmann HP, Nguyen B, Freedman J. Delivering labeled teaching images over the Web. Proc AMIA Symp. 1998; 418-22. PMID: 9929253; PMCID: PMC2232358.
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    188. Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997 Jul 15; 100(2):350-6. PMID: 9218511.
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    189. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 Jul 4; 272(27):17012-7. PMID: 9202015.
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    190. Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54. PMID: 9217172.
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    191. Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21. PMID: 9133522.
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    192. Freedman JE, Loscalzo J. Endothelial dysfunction and atherothrombotic occlusive disease. Drugs. 1997; 54 Suppl 3:41-9; discussion 49-50. PMID: 9360851.
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    193. Kühne T, Freedman J, Semple JW, Doyle J, Butchart S, Blanchette VS. Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. J Pediatr. 1997 Jan; 130(1):17-24. PMID: 9003846.
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    194. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40. PMID: 8921785.
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    195. Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J Clin Invest. 1996 Feb 15; 97(4):979-87. PMID: 8613552.
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    196. Liu L, Freedman J, Hornstein A, Dewar L, Blajchman MA, Ofosu FA. Plasmin accelerates platelet-dependent prothrombinase formation without activating the platelets. Br J Haematol. 1996 Feb; 92(2):458-65. PMID: 8603017.
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    197. Freedman JE, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest. 1995 Jul; 96(1):394-400. PMID: 7615810.
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    198. Loscalzo J, Pasche B, Ouimet H, Freedman JE. Platelets and plasminogen activation. Thromb Haemost. 1995 Jul; 74(1):291-3. PMID: 8578474.
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    199. Freedman JE, Fabian A, Loscalzo J. Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. Am J Physiol. 1995 Feb; 268(2 Pt 1):C520-6. PMID: 7532361.
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    200. Liu L, Freedman J, Hornstein A, Fenton JW, Ofosu FA. Thrombin binding to platelets and their activation in plasma. Br J Haematol. 1994 Nov; 88(3):592-600. PMID: 7529534.
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    201. Ouimet H, Freedman JE, Loscalzo J. Kinetics and mechanism of platelet-surface plasminogen activation by tissue-type plasminogen activator. Biochemistry. 1994 Mar 15; 33(10):2970-6. PMID: 8130211.
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    202. Rubin B, Chan CC, Burnier M, Munion L, Freedman J. Histopathologic study of the Molteno glaucoma implant in three patients. Am J Ophthalmol. 1990 Oct 15; 110(4):371-9. PMID: 2220971.
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    203. Friedman AM, Ptak W, Freedman J, Green DR, Flood PM. Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma. Prog Clin Biol Res. 1989; 288:281-8. PMID: 2566176.
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    204. Rolbin SH, Abbott D, Musclow E, Papsin F, Lie LM, Freedman J. Epidural anesthesia in pregnant patients with low platelet counts. Obstet Gynecol. 1988 Jun; 71(6 Pt 1):918-20. PMID: 3368173.
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    205. Freedman J, Garvey MB, Salomon de Friedberg Z, Hornstein A, Blanchette V. Random donor platelet crossmatching: comparison of four platelet antibody detection methods. Am J Hematol. 1988 May; 28(1):1-7. PMID: 3285667.
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    206. Flood PM, Friedman A, Freedman J, Horvat B, Reuter P, Ptak W. The role of contrasuppression in tumor regression. Immunol Res. 1988; 7(1):12-22. PMID: 2897407.
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    207. Freedman JE, Aghajanian GK. Role of phosphoinositide metabolites in the prolongation of afterhyperpolarizations by alpha 1-adrenoceptors in rat dorsal raphe neurons. J Neurosci. 1987 Dec; 7(12):3897-906. PMID: 2826720.
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    208. Loscalzo J, Freedman J, Rudd MA, Barsky-Vasserman I, Vaughan DE. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis. 1987 Sep-Oct; 7(5):450-5. PMID: 3675304.
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    209. Loscalzo J, Freedman J. Purification and characterization of human platelet glutathione-S-transferase. Blood. 1986 Jun; 67(6):1595-9. PMID: 3085745.
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    210. Freedman J, Cheong T, Garvey MB. Use of the indirect platelet radioactive antiglobulin test with anti-IgG and anti-C3 in immune and nonimmune thrombocytopenias. Am J Hematol. 1985 Mar; 18(3):297-305. PMID: 3883754.
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