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Chinmay M Trivedi MD, PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
368 Plantation Street
Worcester MA 01605
Phone508-856-6947
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Gujarat University, Gujarat, , IndiaMD
    University of South Carolina Columbia, Columbia, SC, United StatesPHD

    Collapse Overview 
    Collapse overview

    Heart disease, adult and congenital, is the leading cause of morbidity and mortality in the developed world due to inability of existing treatment to replace damaged and lost heart tissue. Heart is one of the least regenerative organs in the body with limited endogenous ability to repair or replace affected cardiomyocytes. The research goal of the Trivedi lab is to identify cellular processes and regulatory mechanisms involved in congenital heart diseases and thereby, cardiac growth and development. Mechanistic insights into embryonic cardiac growth pathways could pave the way to repair the injured embryonic and adult heart.


    Although transcription factors involved in cardiac growth and development have been described, the closely associated chromatin modifiers of this process remain largely unknown. Histone deacetylases (Hdacs) modify chromatin structure to regulate gene expression in the heart and elsewhere. Using knockout and transgenic murine models, we have characterized chromatin modifying enzymes and signaling pathways critical for lymphatic vascular disease (The Journal of Clinical Investigation), congenital heart defects (JBC), cardiac progenitor cell differentiation (Human Molecular Genetics), cardiomyocyte proliferation (Developmental Cell, JBC), craniofacial defects (Developmental Dynamics), and hypertrophic cardiomyopathy (Nature Medicine).


    Recently, the Trivedi lab has established a critical interplay between chromatin modifying enzymes and transcription factors during pathogenesis of congenital heart defects (Human Molecular Genetics). We described a specific and novel function of Hdac3 in cardiac progenitor cells during early murine heart development. TBX5, the causative gene in the Holt-Oram Syndrome, was the first identified single-gene mutation giving rise to congenital heart defects. Our studies reveal a critical mechanistic relationship between TBX5G125R, a gain-of-function mutation identified in patients with Holt-Oram Syndrome, and Hdac3. We uncover a mechanism whereby Hdac3 physically interacts with Tbx5 and modulates its acetylation to repress Tbx5-dependent activation of cardiomyocyte lineage-specific genes.


    Interestingly, the human TBX5G125R gain-of- function mutation coincides with the T-box domain required for interaction with Hdac3. TBX5G125R mutation strikingly diminishes its interaction with Hdac3. Further, we demonstrate that HDAC3 deacetylates TBX5 but not TBX5G125R. We identified conserved acetylation sites of TBX5, Lys157 and Lys159, which are important for EP300-mediated acetylation and transcriptional activation. Thus, Hdac3 is required to maintain the pluripotent state of cardiac progenitor cells. These discoveries have opened new areas of investigation and contributed to growing appreciation that HDACs are master regulators of cardiomyocyte homeostasis and function.



     



    Collapse Rotation Projects

    Rotation Projects:

    Please contact Chinmay Trivedi (chinmay.trivedi@umassmed.edu) for information regarding potential rotation projects. We will develop a specific rotation project based on student's interest, background, and goals of the rotation. Students can rotate either for a half- or full-semester.

    Project 1: Characterize progressive lineage restriction of cardiac progenitor cells in murine model.
    Project 2: Identify novel chromatin modifiers regulating specification of murine cardiac progenitor cells. 
    Project 3: Characterize cellular interactions during murine cardiac development and diseases.
    Project 4: Determine novel roles of epigenetic modifications during cardiac diseases.


    Collapse Post Docs


    A Postdoctoral position is available in the Trivedi lab to study roles of novel chromatin and epigenetic modifications during cardiac development and disease (Human Molecular Genetics. 2014 Jul 15;23(14):3801-9, Dev Cell. 2010 Sept 14;19(3):450-9, Nat Med. 2007 Mar;13 (3):324-31, Cell Stem Cell. 2011 Apr 8;8(4):376-88 for details of our research).  Candidates with a PhD in Biochemistry, Molecular Biology, Stem Cell Biology or Developmental Biology are encouraged to apply. Previous experience with mice handling and biochemistry-molecular biology-epigenetics related techniques such as ChIP-seq is strongly desired. Candidate will be required to learn new techniques in the area of progenitor / stem cell biology to advance their project.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zelic M, Roderick JE, O'Donnell JA, Lehman J, Lim SE, Janardhan HP, Trivedi CM, Pasparakis M, Kelliher MA. RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome. J Clin Invest. 2018 Apr 16. PMID: 29664014.
      View in: PubMed
    2. Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF, Trivedi CM. Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Oct 16. PMID: 29035278.
      View in: PubMed
    3. Milstone ZJ, Lawson G, Trivedi CM. Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development and craniofacial morphogenesis. Dev Dyn. 2017 Aug 09. PMID: 28791750.
      View in: PubMed
    4. Lewandowski SL, Janardhan HP, Trivedi CM. Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-ß1 (TGF-ß1) to Orchestrate Second Heart Field Development. J Biol Chem. 2015 Nov 06; 290(45):27067-89. PMID: 26420484.
      View in: PubMed
    5. Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BL, Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun. 2015 Apr 13; 6:6727. PMID: 25865356.
      View in: PubMed
    6. Kayyali US, Larsen CG, Bashiruddin S, Lewandowski SL, Trivedi CM, Warburton RR, Parkhitko AA, Morrison TA, Henske EP, Chekaluk Y, Kwiatkowski DJ, Finlay GA. Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload. Cardiovasc Pathol. 2015 Mar-Apr; 24(2):80-93. PMID: 25434723.
      View in: PubMed
    7. Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM. Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum Mol Genet. 2014 Jul 15; 23(14):3801-9. PMID: 24565863.
      View in: PubMed
    8. Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15; 377(2):333-44. PMID: 23506836.
      View in: PubMed
    9. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA. Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):132-8. PMID: 22298527.
      View in: PubMed
    10. Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res. 2011 Nov 11; 109(11):1240-9. PMID: 21959220.
      View in: PubMed
    11. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011 Apr 8; 8(4):376-88. PMID: 21474102.
      View in: PubMed
    12. Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP. Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Mol Cell Biol. 2011 Jun; 31(11):2349-63. PMID: 21444723.
      View in: PubMed
    13. Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. J Mol Cell Cardiol. 2011 Jun; 50(6):1056-8. PMID: 21382376.
      View in: PubMed
    14. Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metab. 2011 Jan 5; 13(1):3-4. PMID: 21195341.
      View in: PubMed
    15. Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010 Sep 14; 19(3):450-9. PMID: 20833366.
      View in: PubMed
    16. Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. J Biol Chem. 2010 Apr 23; 285(17):13304-13. PMID: 20185820.
      View in: PubMed
    17. Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009 Dec 4; 105(12):1240-7. PMID: 19875726.
      View in: PubMed
    18. Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest. 2008 Nov; 118(11):3609-18. PMID: 18830417.
      View in: PubMed
    19. Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008 Sep 26; 283(39):26484-9. PMID: 18625706.
      View in: PubMed
    20. Trivedi CM, Patel RC, Patel CV. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. Gene. 2008 Jan 31; 408(1-2):187-95. PMID: 18068911.
      View in: PubMed
    21. Trivedi CM, Patel RC, Patel CV. Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium. Atherosclerosis. 2007 Dec; 195(2):e50-60. PMID: 17586512.
      View in: PubMed
    22. Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar; 13(3):324-31. PMID: 17322895.
      View in: PubMed
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