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Last Name
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Jeffrey J Rade MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine


    Collapse Biography 
    Collapse education and training
    University of Notre Dame, Notre Dame, IN, United StatesBSChemistry & Literature
    Case Western Reserve University School of Medicine, Cleveland, OH, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kuliopulos A, Gurbel PA, Rade JJ, Kimmelstiel CD, Turner SE, Bliden KP, Fletcher EK, Cox DH, Covic L. PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study. Arterioscler Thromb Vasc Biol. 2020 Oct 08; ATVBAHA120315168. PMID: 33028101.
      View in: PubMed
    2. Qureshi WT, Al-Drugh S, Ogunsua A, Harrington C, Aman W, Balsam L, Kar B, Aurigemma G, Kundu A, Kaur N, Smith C, Fisher D, Rade J, Kakouros N. Post myocardial infarction complications during the COVID-19 pandemic - A case series. Cardiovasc Revasc Med. 2020 Aug 10. PMID: 32863191.
      View in: PubMed
    3. Garcia S, Stanberry L, Schmidt C, Sharkey S, Megaly M, Albaghdadi MS, Meraj PM, Garberich R, Jaffer FA, Stefanescu Schmidt AC, Dixon SR, Rade JJ, Smith T, Tannenbaum M, Chambers J, Aguirre F, Huang PP, Kumbhani DJ, Koshy T, Feldman DN, Giri J, Kaul P, Thompson C, Khalili H, Maini B, Nayak KR, Cohen MG, Bangalore S, Shah B, Henry TD. Impact of COVID-19 pandemic on STEMI care: An expanded analysis from the United States. Catheter Cardiovasc Interv. 2020 Aug 07. PMID: 32767652.
      View in: PubMed
    4. Garcia S, Albaghdadi MS, Meraj PM, Schmidt C, Garberich R, Jaffer FA, Dixon S, Rade JJ, Tannenbaum M, Chambers J, Huang PP, Henry TD. Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States during COVID-19 Pandemic. J Am Coll Cardiol. 2020 Apr 09. PMID: 32283124.
      View in: PubMed
    5. Zareh M, Rade JJ, Thomas JL, Shah A, Chhabra A, Prutkin J, Shinar Z, Abraham M, Deal N, Kuo D, Pearson D, Garvey L, Lange D, Henry TD, Desai S, Kim H, Swadron S, Tun H, Shavelle DM. ST-Segment Elevation Myocardial Infarction and Out-of-Hospital Cardiac Arrest: Contemporary Management From the Multicenter START Registry. J Invasive Cardiol. 2020 Jan 15. PMID: 31941835.
      View in: PubMed
    6. Hariri E, Lessard D, Gore J, Rade J, Goldberg R. Are we optimizing the use of dual antiplatelet therapy in patients hospitalized with acute myocardial infarction? Cardiovasc Revasc Med. 2019 May 02. PMID: 31129036.
      View in: PubMed
    7. Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019 Apr 16; 10(1):1780. PMID: 30992428.
      View in: PubMed
    8. Rana R, Huang T, Koukos G, Fletcher EK, Turner SE, Shearer A, Gurbel PA, Rade JJ, Kimmelstiel CD, Bliden KP, Covic L, Kuliopulos A. Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018 Jun; 38(6):1368-1380. PMID: 29622563.
      View in: PubMed
    9. Kakouros N, Gluckman TJ, Conte JV, Kickler TS, Laws K, Barton BA, Rade JJ. Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long-Term Outcome After Cardiac Surgery. J Am Heart Assoc. 2017 Nov 02; 6(11). PMID: 29097390.
      View in: PubMed
    10. Kakouros N, Nazarian SM, Stadler PB, Kickler TS, Rade JJ. Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery. J Am Heart Assoc. 2016 Mar 15; 5(3):e002615. PMID: 27068626.
      View in: PubMed
    11. Kakouros N, Rade JJ. Role of Fractional-Flow Reserve in Guiding Percutaneous Revascularization in Stable Coronary Artery Disease. Curr Atheroscler Rep. 2015 Sep; 17(9):52. PMID: 26202795.
      View in: PubMed
    12. Rade JJ. Routine thienopyridine pretreatment for acute coronary syndrome without ST elevation. BMJ. 2014; 349:g6282. PMID: 25954989.
      View in: PubMed
    13. Rade JJ. FFR-guided PCI--FAME may not be so fleeting after all. N Engl J Med. 2014 Sep 25; 371(13):1251-3. PMID: 25176288.
      View in: PubMed
    14. Barringhaus KG, Akhter M, Rade JJ, Smith C, Fisher DZ. Operator and institutional experience reduces room-to-balloon times for transradial primary percutaneous coronary intervention. J Invasive Cardiol. 2014 Feb; 26(2):80-6. PMID: 24486667.
      View in: PubMed
    15. Kakouros N, Kickler TS, Laws KM, Rade JJ. Hematocrit alters VerifyNow P2Y12 assay results independently of intrinsic platelet reactivity and clopidogrel responsiveness. J Thromb Haemost. 2013 Oct; 11(10):1814-22. PMID: 24118870.
      View in: PubMed
    16. DeFilippis AP, Oloyede OS, Andrikopoulou E, Saenger AK, Palachuvattil JM, Fasoro YA, Guallar E, Blumenthal RS, Kickler TS, Jaffe AS, Gerstenblith G, Schulman SP, Rade JJ. Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction. Circ J. 2013; 77(11):2786-92. PMID: 23985963.
      View in: PubMed
    17. Gleim S, Stitham J, Tang WH, Li H, Douville K, Chelikani P, Rade JJ, Martin KA, Hwa J. Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis. PLoS One. 2013; 8(6):e67314. PMID: 23840660.
      View in: PubMed
    18. Olson MT, Kickler TS, Lawson JA, McLean RC, Jani J, FitzGerald GA, Rade JJ. Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk. J Thromb Haemost. 2012 Dec; 10(12):2462-9. PMID: 23072449.
      View in: PubMed
    19. Rade JJ. Platelet function testing in patients with coronary artery disease: is the Who and the When any clearer than the What and the What then? Circulation. 2012 Jun 26; 125(25):3073-5. PMID: 22619281.
      View in: PubMed
    20. McLean RC, Nazarian SM, Gluckman TJ, Schulman SP, Thiemann DR, Shapiro EP, Conte JV, Thompson JB, Shafique I, McNicholas KW, Villines TC, Laws KM, Rade JJ. Relative importance of patient, procedural and anatomic risk factors for early vein graft thrombosis after coronary artery bypass graft surgery. J Cardiovasc Surg (Torino). 2011 Dec; 52(6):877-85. PMID: 22051997.
      View in: PubMed
    21. Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. J Clin Invest. 2011 Nov; 121(11):4462-76. PMID: 22005299.
      View in: PubMed
    22. Kakouros N, Rade JJ, Kourliouros A, Resar JR. Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective. Int J Endocrinol. 2011; 2011:742719. PMID: 21869886.
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    23. Kapur NK, Bian C, Lin E, Deming CB, Sperry JL, Hansen BS, Kakouros N, Rade JJ. Inhibition of transforming growth factor-ß restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011 Oct; 54(4):1117-1123.e1. PMID: 21803524.
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    24. Flaherty MP, Johnston PV, Rade JJ. Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel. J Invasive Cardiol. 2011 Jul; 23(7):300-4. PMID: 21725128.
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    25. Lynch DR, Kickler TS, Rade JJ. Recurrent myocardial infarction associated with gefitinib therapy. J Thromb Thrombolysis. 2011 Jul; 32(1):120-4. PMID: 21184253.
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    26. Brown C, Joshi B, Faraday N, Shah A, Yuh D, Rade JJ, Hogue CW. Emergency cardiac surgery in patients with acute coronary syndromes: a review of the evidence and perioperative implications of medical and mechanical therapeutics. Anesth Analg. 2011 Apr; 112(4):777-99. PMID: 21385977.
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    27. Gluckman TJ, McLean RC, Schulman SP, Kickler TS, Shapiro EP, Conte JV, McNicholas KW, Segal JB, Rade JJ. Effects of aspirin responsiveness and platelet reactivity on early vein graft thrombosis after coronary artery bypass graft surgery. J Am Coll Cardiol. 2011 Mar 1; 57(9):1069-77. PMID: 21349398.
      View in: PubMed
    28. Rade JJ, Hogue CW. Do we really need another biomarker to diagnose myocardial infarction after coronary artery bypass graft surgery? Anesth Analg. 2010 Nov; 111(5):1086-7. PMID: 20971957.
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    29. Zhao H, Hiroi T, Hansen BS, Rade JJ. Cyclic stretch induces cyclooxygenase-2 gene expression in vascular endothelial cells via activation of nuclear factor kappa-beta. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):599-601. PMID: 19748489.
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    30. Hiroi T, Deming CB, Zhao H, Hansen BS, Arkenbout EK, Myers TJ, McDevitt MA, Rade JJ. Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1587-93. PMID: 19661484.
      View in: PubMed
    31. Gluckman TJ, Segal JB, Schulman SP, Shapiro EP, Kickler TS, Prechel MM, Conte JV, Walenga JM, Shafique I, Rade JJ. Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost. 2009 Sep; 7(9):1457-64. PMID: 19552638.
      View in: PubMed
    32. Nazarian SM, Thompson JB, Gluckman TJ, Laws K, Jani JT, Kickler TS, Rade JJ. Clinical and laboratory factors associated with shear-dependent platelet hyper-reactivity in patients on chronic aspirin therapy. Thromb Res. 2010 Nov; 126(5):379-83. PMID: 19501388.
      View in: PubMed
    33. Rade JJ, Hogue CW. Noncardiac surgery for patients with coronary artery stents: timing is everything. Anesthesiology. 2008 Oct; 109(4):573-5. PMID: 18813033.
      View in: PubMed
    34. Kapur NK, Rade JJ. Fibroblast growth factor 4 gene therapy for chronic ischemic heart disease. Trends Cardiovasc Med. 2008 May; 18(4):133-41. PMID: 18555186.
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    35. Kapur NK, Deming CB, Kapur S, Bian C, Champion HC, Donahue JK, Kass DA, Rade JJ. Hemodynamic modulation of endocardial thromboresistance. Circulation. 2007 Jan 2; 115(1):67-75. PMID: 17190863.
      View in: PubMed
    36. Bilchick KC, Rade JJ, Marine JE. Change in H-H' interval during intrahisian block: What is the mechanism? Heart Rhythm. 2007 Jan; 4(1):104-5. PMID: 17199001.
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    37. Gluckman TJ, Rade JJ, Schulman SP. The value of clopidogrel administered postoperatively following a non-ST-segment elevation acute coronary syndrome. Chest. 2005 Jun; 127(6):2297. PMID: 15947369.
      View in: PubMed
    38. Gluckman TJ, Segal JB, Fredde NL, Saland KE, Jani JT, Walenga JM, Prechel MM, Citro KM, Zidar DA, Fox E, Schulman SP, Kickler TS, Rade JJ. Incidence of antiplatelet factor 4/heparin antibody induction in patients undergoing percutaneous coronary revascularization. Am J Cardiol. 2005 Mar 15; 95(6):744-7. PMID: 15757601.
      View in: PubMed
    39. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005 Feb 10; 352(6):539-48. PMID: 15703419.
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    40. Sohn RH, Deming CB, Johns DC, Champion HC, Bian C, Gardner K, Rade JJ. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B. Blood. 2005 May 15; 105(10):3910-7. PMID: 15677570.
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    41. Bauer A, McDonald AD, Nasir K, Peller L, Rade JJ, Miller JM, Heldman AW, Donahue JK. Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation. Circulation. 2004 Nov 9; 110(19):3115-20. PMID: 15505099.
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    42. Deming CB, Kim AY, Bian CE, Regard JB, Rade JJ. cDNA cloning of rabbit thrombomodulin and characterization of gene expression in cardiovascular tissue. DNA Seq. 2003 Dec; 14(6):399-405. PMID: 15018348.
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    43. Grines CL, Watkins MW, Mahmarian JJ, Iskandrian AE, Rade JJ, Marrott P, Pratt C, Kleiman N. A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina. J Am Coll Cardiol. 2003 Oct 15; 42(8):1339-47. PMID: 14563572.
      View in: PubMed
    44. Cao W, Baniecki ML, McGrath WJ, Bao C, Deming CB, Rade JJ, Lowenstein CJ, Mangel WF. Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo. FASEB J. 2003 Dec; 17(15):2345-6. PMID: 14525937.
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    45. Chou ET, Schulman SP, Thiemann DR, Sohn RH, Bellantoni MF, Rade JJ. Effect of short-term estrogen with and without progesterone therapy on circulating markers of endothelial activation and injury in postmenopausal women with unstable angina pectoris. Am J Cardiol. 2003 May 15; 91(10):1240-2. PMID: 12745110.
      View in: PubMed
    46. Sperry JL, Deming CB, Bian C, Walinsky PL, Kass DA, Kolodgie FD, Virmani R, Kim AY, Rade JJ. Wall tension is a potent negative regulator of in vivo thrombomodulin expression. Circ Res. 2003 Jan 10; 92(1):41-7. PMID: 12522119.
      View in: PubMed
    47. Kim AY, Walinsky PL, Kolodgie FD, Bian C, Sperry JL, Deming CB, Peck EA, Shake JG, Ang GB, Sohn RH, Esmon CT, Virmani R, Stuart RS, Rade JJ. Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failure. Circ Res. 2002 Feb 8; 90(2):205-12. PMID: 11834714.
      View in: PubMed
    48. Donahue JK, Heldman AW, Fraser H, McDonald AD, Miller JM, Rade JJ, Eschenhagen T, Marbán E. Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med. 2000 Dec; 6(12):1395-8. PMID: 11100126.
      View in: PubMed
    49. Zablocki DK, Rade JJ, Alevriadou BR. Adenovirus-mediated expression of tissue plasminogen activator does not alter endothelial cell proliferation and invasion. In Vitro Cell Dev Biol Anim. 2000 Nov-Dec; 36(10):625-8. PMID: 11229592.
      View in: PubMed
    50. Faraday N, Rade JJ, Johns DC, Khetawat G, Noga SJ, DiPersio JF, Jin Y, Nichol JL, Haug JS, Bray PF. Ex vivo cultured megakaryocytes express functional glycoprotein IIb-IIIa receptors and are capable of adenovirus-mediated transgene expression. Blood. 1999 Dec 15; 94(12):4084-92. PMID: 10590053.
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    51. Lundell A, Kelly AB, Anderson J, Marijianowski M, Rade JJ, Hanson SR, Harker LA. Reduction in vascular lesion formation by hirudin secreted from retrovirus-transduced confluent endothelial cells on vascular grafts in baboons. Circulation. 1999 Nov 9; 100(19):2018-24. PMID: 10556229.
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    52. Rade JJ, Cheung M, Miyamoto S, Dichek DA. Retroviral vector-mediated expression of hirudin by human vascular endothelial cells: implications for the design of retroviral vectors expressing biologically active proteins. Gene Ther. 1999 Mar; 6(3):385-92. PMID: 10435088.
      View in: PubMed
    53. Schulick AH, Vassalli G, Dunn PF, Dong G, Rade JJ, Zamarron C, Dichek DA. Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity. J Clin Invest. 1997 Jan 15; 99(2):209-19. PMID: 9005989.
      View in: PubMed
    54. Rade JJ, Schulick AH, Virmani R, Dichek DA. Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med. 1996 Mar; 2(3):293-8. PMID: 8612227.
      View in: PubMed
    55. Lee SW, Trapnell BC, Rade JJ, Virmani R, Dichek DA. In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circ Res. 1993 Nov; 73(5):797-807. PMID: 8403251.
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