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Jeremy Luban MD

TitleProfessor
Endowed TitleDavid J. Freelander Memorial Professor in AIDS Research
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 119
Worcester MA 01605
Phone508-856-3664
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program


    Collapse Biography 
    Collapse education and training
    State University of New York at Purchase, Purchase, NY, United StatesBABiology
    Columbia University College of Physicians and Surgeons, New York, NY, United StatesMD

    Collapse Overview 
    Collapse overview

    Please visit the Luban Lab Website

    Professor Luban is a physician-scientist who studies the interaction between human cells and deadly pathogens including HIV-1, Ebola virus, and SARS-CoV-2. He has held endowed professorships at Columbia University in New York (where he directed the Columbia-Rockefeller Center for AIDS Research), the University of Geneva in Switzerland, and now the University of Massachusetts Medical School, where he holds the David J. Freelander Chair in AIDS Research. He is an affiliate of the Broad Institute of MIT and Harvard and oversees a program on SARS-CoV-2 as part of the Massachusetts Consortium on Pathogen Readiness. Dr. Luban was elected to the American Society for Clinical Investigation, the Association of American Physicians, and the American Academy of Microbiology. His research program in Virology, Immunology, and Molecular Biology has been continuously funded for the past 30 years by the National Institute of Health and includes Merit and Avant Garde Awards. He has served on editorial boards of four virology journals, on grant review committees and scientific advisory boards for the NIH, the American Cancer Society, the American Foundation for AIDS Research, and has acted as primary mentor for 90 Ph.D. students, post-docs, and undergraduate students.


    Collapse Rotation Projects
    Lab rotation position is available

    Collapse Post Docs
    PostDoc Position available


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J. IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus. bioRxiv. 2023 Dec 12. PMID: 38014177.
      Citations:    
    2. Jain A, Govindan R, Berkman AR, Luban J, D?az-Salinas MA, Durham ND, Munro JB. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. PLoS Pathog. 2023 Dec; 19(12):e1011848. PMID: 38055723.
      Citations:    Fields:    Translation:HumansCells
    3. Normandin E, Triana S, Raju SS, Lan TCT, Lagerborg K, Rudy M, Adams GC, DeRuff KC, Logue J, Liu D, Strebinger D, Rao A, Messer KS, Sacks M, Adams RD, Janosko K, Kotliar D, Shah R, Crozier I, Rinn JL, Mel? M, Honko AN, Zhang F, Babadi M, Luban J, Bennett RS, Shalek AK, Barkas N, Lin AE, Hensley LE, Sabeti PC, Siddle KJ. Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses. Cell Genom. 2023 Dec 13; 3(12):100440. PMID: 38169842.
      Citations:    
    4. Devarajan P, Vong AM, Castonguay CH, Silverstein NJ, Kugler-Umana O, Bautista BL, Kelly KA, Luban J, Swain SL. Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15. Cell Rep. 2023 Nov 28; 42(11):113429. PMID: 37934667.
      Citations: 1     Fields:    
    5. Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Addressing the dNTP bottleneck restricting prime editing activity. bioRxiv. 2023 Oct 29. PMID: 37904991.
      Citations:    
    6. Jain A, Govindan R, Berkman A, Luban J, Durham ND, Munro J. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. bioRxiv. 2023 Oct 17. PMID: 36711925.
      Citations:    
    7. Padron A, Prakash P, Pandhare J, Luban J, Aiken C, Balasubramaniam M, Dash C. Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus. J Virol. 2023 Nov 30; 97(11):e0073223. PMID: 37843371.
      Citations:    Fields:    Translation:HumansCells
    8. Devarajan P, Vong AM, Castonguay CH, Silverstein NJ, Kugler-Umana O, Bautista BL, Kelly KA, Luban J, Swain SL. Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15. Cell Rep. 2023 10 31; 42(10):113182. PMID: 37776519.
      Citations: 1     Fields:    Translation:Cells
    9. Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Maitland SA, Lawson ND, Luban J, Wolfe SA. Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency. Nucleic Acids Res. 2023 07 21; 51(13):6966-6980. PMID: 37246708.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Wang Y, Lifshitz L, Silverstein NJ, Mintzer E, Luk K, StLouis P, Brehm MA, Wolfe SA, Deeks SG, Luban J. Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis. EMBO J. 2023 08 15; 42(16):e114153. PMID: 37382276.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Xue G, Yu HJ, Buffone C, Huang SW, Lee K, Goh SL, Gres AT, Guney MH, Sarafianos SG, Luban J, Diaz-Griffero F, KewalRamani VN. The HIV-1 capsid core is an opportunistic nuclear import receptor. Nat Commun. 2023 06 24; 14(1):3782. PMID: 37355754.
      Citations: 4     Fields:    Translation:HumansCells
    12. Egri SB, Wang X, D?az-Salinas MA, Luban J, Dudkina NV, Munro JB, Shen K. Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination. Nat Commun. 2023 05 03; 14(1):2527. PMID: 37137903.
      Citations: 1     Fields:    Translation:HumansCells
    13. Yurkovetskiy L, Egri S, Kurhade C, Diaz-Salinas MA, Jaimes JA, Nyalile T, Xie X, Choudhary MC, Dauphin A, Li JZ, Munro JB, Shi PY, Shen K, Luban J. S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness. bioRxiv. 2023 Apr 24. PMID: 37034621.
      Citations:    
    14. Adams G, Moreno GK, Petros BA, Uddin R, Levine Z, Kotzen B, Messer KS, Dobbins ST, DeRuff KC, Loreth CM, Brock-Fisher T, Schaffner SF, Chaluvadi S, Kanjilal S, Luban J, Ozonoff A, Park DJ, Turbett SE, Siddle KJ, MacInnis BL, Sabeti PC, Lemieux JE. Viral Lineages in the 2022 RSV Surge in the United States. N Engl J Med. 2023 Apr 06; 388(14):1335-1337. PMID: 36812457.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    15. Odongo L, Zadrozny KK, Diehl WE, Luban J, White JM, Ganser-Pornillos BK, Tamm LK, Pornillos O. Purification and structure of luminal domain C of human Niemann-Pick C1 protein. Acta Crystallogr F Struct Biol Commun. 2023 Feb 01; 79(Pt 2):45-50. PMID: 36748341.
      Citations: 1     Fields:    Translation:HumansCells
    16. Adams G, Moreno GK, Petros BA, Uddin R, Levine Z, Kotzen B, Messer K, Dobbins ST, DeRuff KC, Loreth C, Brock-Fisher T, Schaffner SF, Chaluvadi S, Kanjilal S, Luban J, Ozonoff A, Park D, Turbett S, Siddle KJ, MacInnis BL, Sabeti P, Lemieux J. The 2022 RSV surge was driven by multiple viral lineages. medRxiv. 2023 Jan 05. PMID: 36656774.
      Citations:    
    17. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews JI, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant. JCI Insight. 2022 10 10; 7(19). PMID: 36214224.
      Citations: 10     Fields:    Translation:HumansCells
    18. Petros BA, Paull JS, Tomkins-Tinch CH, Loftness BC, DeRuff KC, Nair P, Gionet GL, Benz A, Brock-Fisher T, Hughes M, Yurkovetskiy L, Mulaudzi S, Leenerman E, Nyalile T, Moreno GK, Specht I, Sani K, Adams G, Babet SV, Baron E, Blank JT, Boehm C, Botti-Lodovico Y, Brown J, Buisker AR, Burcham T, Chylek L, Cronan P, Dauphin A, Desreumaux V, Doss M, Flynn B, Gladden-Young A, Glennon O, Harmon HD, Hook TV, Kary A, King C, Loreth C, Marrs L, McQuade KJ, Milton TT, Mulford JM, Oba K, Pearlman L, Schifferli M, Schmidt MJ, Tandus GM, Tyler A, Vodzak ME, Krohn Bevill K, Colubri A, MacInnis BL, Ozsoy AZ, Parrie E, Sholtes K, Siddle KJ, Fry B, Luban J, Park DJ, Marshall J, Bronson A, Schaffner SF, Sabeti PC. Multimodal surveillance of SARS-CoV-2 at a university enables development of a robust outbreak response framework. Med. 2022 Dec 09; 3(12):883-900.e13. PMID: 36198312.
      Citations:    
    19. Obermeyer F, Jankowiak M, Barkas N, Schaffner SF, Pyle JD, Yurkovetskiy L, Bosso M, Park DJ, Babadi M, MacInnis BL, Luban J, Sabeti PC, Lemieux JE. Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness. Science. 2022 06 17; 376(6599):1327-1332. PMID: 35608456.
      Citations: 104     Fields:    Translation:HumansCells
    20. Lemieux JE, Luban J. Consulting the Oracle of SARS-CoV-2 Infection. J Infect Dis. 2022 04 01; 225(7):1115-1117. PMID: 34940876.
      Citations: 2     Fields:    Translation:HumansCells
    21. D?az-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Elife. 2022 03 24; 11. PMID: 35323111.
      Citations: 21     Fields:    Translation:HumansCells
    22. Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban J. Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection. Elife. 2022 03 11; 11. PMID: 35275061.
      Citations: 19     Fields:    Translation:HumansCells
    23. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews J, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses. medRxiv. 2022 Mar 03. PMID: 35262094.
      Citations:    
    24. Obermeyer F, Jankowiak M, Barkas N, Schaffner SF, Pyle JD, Yurkovetskiy L, Bosso M, Park DJ, Babadi M, MacInnis BL, Luban J, Sabeti PC, Lemieux JE. Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness. medRxiv. 2022 Feb 16. PMID: 35194619.
      Citations:    
    25. D?az-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. bioRxiv. 2021 Nov 09. PMID: 34790979.
      Citations:    
    26. Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L, Meyer NJ, Betts MR, Li JZ, Walker B, Yu XG, Yonker LM, Luban J. Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection. medRxiv. 2021 Oct 11. PMID: 33469605.
      Citations:    
    27. Griesemer D, Xue JR, Reilly SK, Ulirsch JC, Kukreja K, Davis JR, Kanai M, Yang DK, Butts JC, Guney MH, Luban J, Montgomery SB, Finucane HK, Novina CD, Tewhey R, Sabeti PC. Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution. Cell. 2021 09 30; 184(20):5247-5260.e19. PMID: 34534445.
      Citations: 35     Fields:    Translation:HumansCells
    28. Fukuda K, Okamura K, Riding RL, Fan X, Afshari K, Haddadi NS, McCauley SM, Guney MH, Luban J, Funakoshi T, Yaguchi T, Kawakami Y, Khvorova A, Fitzgerald KA, Harris JE. AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma. J Exp Med. 2021 09 06; 218(9). PMID: 34325468.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    29. Lechner K, Mott S, Al-Saifi R, Knipfer L, Wirtz S, Atreya R, Vieth M, Rath T, Fraass T, Winter Z, August A, Luban J, Zimmermann VS, Weigmann B, Neurath MF. Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis. Gastroenterology. 2021 10; 161(4):1270-1287.e19. PMID: 34224738.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. Diehl WE, Guney MH, Vanzo T, Kyawe PP, White JM, Pizzato M, Luban J. Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity. Viruses. 2021 06 30; 13(7). PMID: 34209034.
      Citations: 11     Fields:    Translation:HumansCells
    31. Silverstein NJ, Luban J. Lessons from a local effort to screen for SARS-CoV-2. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34140338.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    32. Tomkins-Tinch CH, Daly JS, Gladden-Young A, Theodoropoulos NM, Madaio MP, Yu N, Vanguri VK, Siddle KJ, Adams G, Krasilnikova LA, Movahedi B, Bozorgzadeh A, Simin K, Lemieux JE, Luban J, Park DJ, MacInnis BL, Sabeti PC, Levitz SM. SARS-CoV-2 Reinfection in a Liver Transplant Recipient. Ann Intern Med. 2021 08; 174(8):1178-1180. PMID: 33872044.
      Citations: 8     Fields:    Translation:HumansCells
    33. Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda JA, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, MacInnis BL. Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events. Science. 2021 02 05; 371(6529). PMID: 33303686.
      Citations: 139     Fields:    Translation:HumansCellsPHPublic Health
    34. Luban J, Sattler RA, M?hlberger E, Graci JD, Cao L, Weetall M, Trotta C, Colacino JM, Bavari S, Strambio-De-Castillia C, Suder EL, Wang Y, Soloveva V, Cintron-Lue K, Naryshkin NA, Pykett M, Welch EM, O'Keefe K, Kong R, Goodwin E, Jacobson A, Paessler S, Peltz SW. The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. Virus Res. 2021 01 15; 292:198246. PMID: 33249060.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    35. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 10 29; 183(3):739-751.e8. PMID: 32991842.
      Citations: 567     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    36. Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda J, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, Maclnnis BL. Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events. medRxiv. 2020 Aug 25. PMID: 32869040.
      Citations:    
    37. Luban J, Sattler R, M?hlberger E, Graci JD, Cao L, Weetall M, Trotta C, Colacino JM, Bavari S, Strambio-De-Castillia C, Suder EL, Wang Y, Soloveva V, Cintron-Lue K, Naryshkin NA, Pykett M, Welch EM, O'Keefe K, Kong R, Goodwin E, Jacobson A, Paessler S, Peltz S. The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. bioRxiv. 2020 Aug 05. PMID: 32793904.
      Citations:    
    38. Henriques F, Bedard AH, Guilherme A, Kelly M, Chi J, Zhang P, Lifshitz LM, Bellv? K, Rowland LA, Yenilmez B, Kumar S, Wang Y, Luban J, Weinstein LS, Lin JD, Cohen P, Czech MP. Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis. Cell Rep. 2020 08 04; 32(5):107998. PMID: 32755590.
      Citations: 32     Fields:    Translation:AnimalsCells
    39. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile T, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro J, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina N, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. bioRxiv. 2020 Jul 15. PMID: 32637944.
      Citations:    
    40. Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5a-dependent manner. PLoS Pathog. 2020 04; 16(4):e1008507. PMID: 32282853.
      Citations: 24     Fields:    Translation:HumansCells
    41. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020 03; 21(3):274-286. PMID: 32066947.
      Citations: 43     Fields:    Translation:HumansCells
    42. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 02; 18(2):e3000626. PMID: 32040508.
      Citations: 41     Fields:    Translation:HumansCells
    43. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 01 15; 12(1). PMID: 31952255.
      Citations: 10     Fields:    Translation:HumansCells
    44. Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC. Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111. Viruses. 2020 01 15; 12(1). PMID: 31952352.
      Citations: 7     Fields:    Translation:HumansCells
    45. Luban J. Retraction Note: The hidden cost of genetic resistance to HIV-1. Nat Med. 2019 11; 25(11):1796. PMID: 31595085.
      Citations:    Fields:    
    46. Kim K, Dauphin A, Komurlu S, McCauley SM, Yurkovetskiy L, Carbone C, Diehl WE, Strambio-De-Castillia C, Campbell EM, Luban J. Cyclophilin A protects HIV-1 from restriction by human TRIM5a. Nat Microbiol. 2019 12; 4(12):2044-2051. PMID: 31636416.
      Citations: 71     Fields:    Translation:HumansCells
    47. Yu T, Koppetsch BS, Pagliarani S, Johnston S, Silverstein NJ, Luban J, Chappell K, Weng Z, Theurkauf WE. The piRNA Response to Retroviral Invasion of the Koala Genome. Cell. 2019 10 17; 179(3):632-643.e12. PMID: 31607510.
      Citations: 35     Fields:    Translation:AnimalsCells
    48. Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, M?ndez-Sol?s O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM. TRIM5a Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation. Cell Rep. 2019 06 11; 27(11):3269-3283.e6. PMID: 31189110.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    49. Luban J. The hidden cost of genetic resistance to HIV-1. Nat Med. 2019 06; 25(6):878-879. PMID: 31160816.
      Citations:    Fields:    Translation:HumansCells
    50. Liu P, Luk K, Shin M, Idrizi F, Kwok S, Roscoe B, Mintzer E, Suresh S, Morrison K, Fraz?o JB, Bolukbasi MF, Ponnienselvan K, Luban J, Zhu LJ, Lawson ND, Wolfe SA. Enhanced Cas12a editing in mammalian cells and zebrafish. Nucleic Acids Res. 2019 May 07; 47(8):4169-4180. PMID: 30892626.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    51. Boucher JI, Whitfield TW, Dauphin A, Nachum G, Hollins C, Zeldovich KB, Swanstrom R, Schiffer CA, Luban J, Bolon DNA. Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution. Mol Biol Evol. 2019 04 01; 36(4):798-810. PMID: 30721995.
      Citations: 5     Fields:    Translation:Cells
    52. Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA. Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J Immunol. 2019 02 01; 202(3):799-804. PMID: 30593536.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    53. McCauley SM, Kim K, Nowosielska A, Dauphin A, Yurkovetskiy L, Diehl WE, Luban J. Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines. Nat Commun. 2018 12 13; 9(1):5305. PMID: 30546110.
      Citations: 35     Fields:    Translation:HumansCells
    54. Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nat Microbiol. 2018 12; 3(12):1354-1361. PMID: 30297740.
      Citations: 53     Fields:    Translation:HumansCells
    55. Donnard E, Vangala P, Afik S, McCauley S, Nowosielska A, Kucukural A, Tabak B, Zhu X, Diehl W, McDonel P, Yosef N, Luban J, Garber M. Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon. Cell Syst. 2018 Mar 28; 6(3):381-394.e7. PMID: 29454939.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    56. Morger D, Zosel F, B?hlmann M, Z?ger S, Mittelviefhaus M, Schuler B, Luban J, Gr?tter MG. The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5a. J Virol. 2018 03 01; 92(5). PMID: 29237846.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    57. Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR. HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded. J Virol. 2018 01 15; 92(2). PMID: 29118121.
      Citations: 9     Fields:    Translation:HumansCells
    58. Alghanem B, Nikitin F, Stricker T, Duchoslav E, Luban J, Strambio-De-Castillia C, Muller M, Lisacek F, Varesio E, Hopfgartner G. Optimization by infusion of multiple reaction monitoring transitions for sensitive quantification of peptides by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2017 May 15; 31(9):753-761. PMID: 28199054.
      Citations:    Fields:    Translation:HumansCells
    59. Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic. Cell. 2016 11 03; 167(4):1088-1098.e6. PMID: 27814506.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    60. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Genome Res. 2016 10; 26(10):1397-1410. PMID: 27470110.
      Citations: 36     Fields:    Translation:AnimalsCells
    61. Luban J. Closing the net on retroviruses. Elife. 2016 07 07; 5. PMID: 27387471.
      Citations:    Fields:    Translation:AnimalsCells
    62. Chen NY, Zhou L, Gane PJ, Opp S, Ball NJ, Nicastro G, Zufferey M, Buffone C, Luban J, Selwood D, Diaz-Griffero F, Taylor I, Fassati A. HIV-1 capsid is involved in post-nuclear entry steps. Retrovirology. 2016 Apr 23; 13:28. PMID: 27107820.
      Citations: 38     Fields:    Translation:HumansCells
    63. Bilbao A, Zhang Y, Varesio E, Luban J, Strambio-De-Castillia C, Lisacek F, Hopfgartner G. Ranking Fragment Ions Based on Outlier Detection for Improved Label-Free Quantification in Data-Independent Acquisition LC-MS/MS. J Proteome Res. 2015 Nov 06; 14(11):4581-93. PMID: 26412574.
      Citations: 6     Fields:    Translation:HumansCells
    64. Lascano J, Uchil PD, Mothes W, Luban J. TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling. J Virol. 2016 01 01; 90(1):308-16. PMID: 26468522.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    65. Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature. 2015 Oct 08; 526(7572):212-7. PMID: 26416734.
      Citations: 252     Fields:    Translation:HumansAnimalsCells
    66. Zhang Y, Bilbao A, Bruderer T, Luban J, Strambio-De-Castillia C, Lisacek F, Hopfgartner G, Varesio E. The Use of Variable Q1 Isolation Windows Improves Selectivity in LC-SWATH-MS Acquisition. J Proteome Res. 2015 Oct 02; 14(10):4359-71. PMID: 26302369.
      Citations: 54     Fields:    Translation:HumansCells
    67. Pizzato M, McCauley SM, Neagu MR, Pertel T, Firrito C, Ziglio S, Dauphin A, Zufferey M, Berthoux L, Luban J. Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration. PLoS Pathog. 2015 Jul; 11(7):e1005050. PMID: 26181333.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    68. Zhang Y, Bottinelli D, Lisacek F, Luban J, Strambio-De-Castillia C, Varesio E, Hopfgartner G. Optimization of human dendritic cell sample preparation for mass spectrometry-based proteomic studies. Anal Biochem. 2015 Sep 01; 484:40-50. PMID: 25983236.
      Citations: 8     Fields:    Translation:HumansCells
    69. Bilbao A, Varesio E, Luban J, Strambio-De-Castillia C, Hopfgartner G, M?ller M, Lisacek F. Processing strategies and software solutions for data-independent acquisition in mass spectrometry. Proteomics. 2015 Mar; 15(5-6):964-80. PMID: 25430050.
      Citations: 60     Fields:    
    70. Bartels H, Luban J. Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA. Retrovirology. 2014 Sep 12; 11:73. PMID: 25212909.
      Citations: 15     Fields:    Translation:HumansCells
    71. Reinhard C, Bottinelli D, Kim B, Luban J. Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration. Retrovirology. 2014 Feb 01; 11:12. PMID: 24485168.
      Citations: 30     Fields:    Translation:HumansCells
    72. De Iaco A, Luban J. Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA. Retrovirology. 2014 Jan 30; 11:11. PMID: 24479545.
      Citations: 64     Fields:    Translation:HumansCells
    73. Singh R, Patel V, Mureithi MW, Naranbhai V, Ramsuran D, Tulsi S, Hiramen K, Werner L, Mlisana K, Altfeld M, Luban J, Kasprowicz V, Dheda K, Abdool Karim SS, Ndung'u T. TRIM5a and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. J Virol. 2014 Apr; 88(8):4291-303. PMID: 24478420.
      Citations: 14     Fields:    Translation:HumansCells
    74. Yang Y, Luban J, Diaz-Griffero F. The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating. Methods Mol Biol. 2014; 1087:29-36. PMID: 24158811.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    75. Brehm MA, Shultz LD, Luban J, Greiner DL. Overcoming current limitations in humanized mouse research. J Infect Dis. 2013 Nov; 208 Suppl 2:S125-30. PMID: 24151318.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    76. Xu H, Franks T, Gibson G, Huber K, Rahm N, Strambio De Castillia C, Luban J, Aiken C, Watkins S, Sluis-Cremer N, Ambrose Z. Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay. Retrovirology. 2013 Jul 09; 10:70. PMID: 23835323.
      Citations: 55     Fields:    Translation:HumansCells
    77. De Iaco A, Santoni F, Vannier A, Guipponi M, Antonarakis S, Luban J. TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. Retrovirology. 2013 Feb 15; 10:20. PMID: 23414560.
      Citations: 102     Fields:    Translation:HumansCells
    78. Santoni FA, Guerra J, Luban J. HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency. Retrovirology. 2012 Dec 20; 9:111. PMID: 23253934.
      Citations: 107     Fields:    Translation:HumansCells
    79. Luban J. More than one way to TRIM a capsid. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19517-8. PMID: 23150592.
      Citations: 2     Fields:    Translation:Humans
    80. Miyamoto T, Nakayama EE, Yokoyama M, Ibe S, Takehara S, Kono K, Yokomaku Y, Pizzato M, Luban J, Sugiura W, Sato H, Shioda T. The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5a. PLoS One. 2012; 7(10):e47757. PMID: 23094081.
      Citations: 5     Fields:    Translation:HumansCells
    81. Luban J. Innate immune sensing of HIV-1 by dendritic cells. Cell Host Microbe. 2012 Oct 18; 12(4):408-18. PMID: 23084911.
      Citations: 53     Fields:    Translation:Cells
    82. Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol. 2013 Jan; 87(1):257-72. PMID: 23077300.
      Citations: 112     Fields:    Translation:HumansCells
    83. Luban J. TRIM5 and the Regulation of HIV-1 Infectivity. Mol Biol Int. 2012; 2012:426840. PMID: 22701176.
      Citations:    
    84. Gr?tter MG, Luban J. TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. Curr Opin Virol. 2012 Apr; 2(2):142-50. PMID: 22482711.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    85. Lai RP, Yan J, Heeney J, McClure MO, G?ttlinger H, Luban J, Pizzato M. Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. PLoS Pathog. 2011 Dec; 7(12):e1002442. PMID: 22194689.
      Citations: 31     Fields:    Translation:HumansCells
    86. De Iaco A, Luban J. Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus. Retrovirology. 2011 Dec 06; 8:98. PMID: 22145813.
      Citations: 71     Fields:    Translation:HumansCells
    87. Lukic Z, Hausmann S, Sebastian S, Rucci J, Sastri J, Robia SL, Luban J, Campbell EM. TRIM5a associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011 Nov 12; 8:93. PMID: 22078707.
      Citations: 32     Fields:    Translation:HumansCells
    88. Pertel T, Reinhard C, Luban J. Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon. Retrovirology. 2011 Jun 22; 8:49. PMID: 21696578.
      Citations: 49     Fields:    Translation:HumansCells
    89. Pertel T, Hausmann S, Morger D, Z?ger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Gr?tter MG, Luban J. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011 Apr 21; 472(7343):361-5. PMID: 21512573.
      Citations: 359     Fields:    Translation:HumansCells
    90. Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E. TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements. J Virol. 2011 May; 85(10):5183-96. PMID: 21345949.
      Citations: 63     Fields:    Translation:HumansCells
    91. Santoni FA, Hartley O, Luban J. Deciphering the code for retroviral integration target site selection. PLoS Comput Biol. 2010 Nov 24; 6(11):e1001008. PMID: 21124862.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    92. Su?? G, Sarr? E, Puigmul? M, L?pez-Hell?n J, Zufferey M, Pertel T, Luban J, Meseguer A. Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney. PLoS One. 2010 Nov 10; 5(11):e13930. PMID: 21085665.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    93. Singh R, Gaiha G, Werner L, McKim K, Mlisana K, Luban J, Walker BD, Karim SS, Brass AL, Ndung'u T. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol. 2011 Jan; 85(1):208-16. PMID: 20980524.
      Citations: 37     Fields:    Translation:HumansCells
    94. Bernasconi R, Sold? T, Galli C, Pertel T, Luban J, Molinari M. Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation. PLoS One. 2010 Sep 28; 5(9). PMID: 20927389.
      Citations: 21     Fields:    Translation:HumansCells
    95. O'Connor C, Pertel T, Gray S, Robia SL, Bakowska JC, Luban J, Campbell EM. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J Virol. 2010 Jun; 84(12):5997-6006. PMID: 20357094.
      Citations: 39     Fields:    Translation:HumansCells
    96. Sokolskaja E, Olivari S, Zufferey M, Strambio-De-Castillia C, Pizzato M, Luban J. Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions. J Virol. 2010 May; 84(9):4851-5. PMID: 20181694.
      Citations: 8     Fields:    Translation:HumansCells
    97. van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, L?stun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I. Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17019-24. PMID: 19805154.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    98. Strebel K, Luban J, Jeang KT. Human cellular restriction factors that target HIV-1 replication. BMC Med. 2009 Sep 16; 7:48. PMID: 19758442.
      Citations: 81     Fields:    Translation:HumansCells
    99. Neagu MR, Ziegler P, Pertel T, Strambio-De-Castillia C, Gr?tter C, Martinetti G, Mazzucchelli L, Gr?tter M, Manz MG, Luban J. Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. J Clin Invest. 2009 Oct; 119(10):3035-47. PMID: 19741300.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    100. Mangeat B, Gers-Huber G, Lehmann M, Zufferey M, Luban J, Piguet V. HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation. PLoS Pathog. 2009 Sep; 5(9):e1000574. PMID: 19730691.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    101. Kaul A, Stauffer S, Berger C, Pertel T, Schmitt J, Kallis S, Zayas M, Lopez MZ, Lohmann V, Luban J, Bartenschlager R. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog. 2009 Aug; 5(8):e1000546. PMID: 19680534.
      Citations: 145     Fields:    Translation:HumansCells
    102. Marq JB, Hausmann S, Luban J, Kolakofsky D, Garcin D. The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon beta. J Biol Chem. 2009 Sep 18; 284(38):25471-8. PMID: 19584049.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    103. Sebastian S, Gr?tter C, Strambio de Castillia C, Pertel T, Olivari S, Gr?tter MG, Luban J. An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding. J Virol. 2009 Apr; 83(7):3365-73. PMID: 19153241.
      Citations: 20     Fields:    Translation:HumansCells
    104. Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, Darlix JL, Cimarelli A. Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. J Virol. 2008 Dec; 82(24):12335-45. PMID: 18829761.
      Citations: 90     Fields:    Translation:HumansCells
    105. Luban J. HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase. Curr Biol. 2008 Aug 26; 18(16):R710-3. PMID: 18727908.
      Citations: 14     Fields:    Translation:Cells
    106. Santoni de Sio FR, Gritti A, Cascio P, Neri M, Sampaolesi M, Galli C, Luban J, Naldini L. Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells. Stem Cells. 2008 Aug; 26(8):2142-52. PMID: 18483423.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    107. Bernasconi R, Pertel T, Luban J, Molinari M. A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. J Biol Chem. 2008 Jun 13; 283(24):16446-54. PMID: 18417469.
      Citations: 62     Fields:    Translation:HumansCells
    108. Zhu C, Wang X, Deinum J, Huang Z, Gao J, Modjtahedi N, Neagu MR, Nilsson M, Eriksson PS, Hagberg H, Luban J, Kroemer G, Blomgren K. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med. 2007 Aug 06; 204(8):1741-8. PMID: 17635954.
      Citations: 92     Fields:    Translation:AnimalsCells
    109. Takeuchi H, Buckler-White A, Goila-Gaur R, Miyagi E, Khan MA, Opi S, Kao S, Sokolskaja E, Pertel T, Luban J, Strebel K. Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells. J Virol. 2007 Aug; 81(15):8080-90. PMID: 17522232.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    110. Berthoux L, Sebastian S, Muesing MA, Luban J. The role of lysine 186 in HIV-1 integrase multimerization. Virology. 2007 Jul 20; 364(1):227-36. PMID: 17397894.
      Citations: 20     Fields:    Translation:HumansCells
    111. Sebastian S, Luban J. The retroviral restriction factor TRIM5alpha. Curr Infect Dis Rep. 2007 Mar; 9(2):167-73. PMID: 17324355.
      Citations:    
    112. Luban J. Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J Virol. 2007 Feb; 81(3):1054-61. PMID: 16956947.
      Citations: 89     Fields:    Translation:HumansCells
    113. Zhang S, Joseph G, Pollok K, Berthoux L, Sastry L, Luban J, Cornetta K. G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer. Mol Ther. 2006 Oct; 14(4):546-54. PMID: 16901758.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    114. Sokolskaja E, Luban J. Cyclophilin, TRIM5, and innate immunity to HIV-1. Curr Opin Microbiol. 2006 Aug; 9(4):404-8. PMID: 16815734.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    115. Sokolskaja E, Berthoux L, Luban J. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol. 2006 Mar; 80(6):2855-62. PMID: 16501094.
      Citations: 61     Fields:    Translation:HumansCells
    116. Sebastian S, Sokolskaja E, Luban J. Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner. J Virol. 2006 Feb; 80(4):2051-4. PMID: 16439561.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    117. Berthoux L, Sebastian S, Sokolskaja E, Luban J. Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14849-53. PMID: 16203999.
      Citations: 92     Fields:    Translation:AnimalsCells
    118. Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest. 2005 Oct; 115(10):2904-13. PMID: 16167085.
      Citations: 125     Fields:    Translation:HumansCells
    119. Sebastian S, Luban J. TRIM5alpha selectively binds a restriction-sensitive retroviral capsid. Retrovirology. 2005 Jun 20; 2:40. PMID: 15967037.
      Citations: 159     Fields:    
    120. Berthoux L, Sebastian S, Sayah DM, Luban J. Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues. J Virol. 2005 Jun; 79(12):7883-8. PMID: 15919943.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    121. Colgan J, Asmal M, Yu B, Luban J. Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. J Immunol. 2005 May 15; 174(10):6030-8. PMID: 15879096.
      Citations: 44     Fields:    Translation:AnimalsCells
    122. Gurer C, H?glund A, H?glund S, Luban J. ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity. J Virol. 2005 May; 79(9):5557-67. PMID: 15827170.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    123. Gurer C, Berthoux L, Luban J. Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1. J Virol. 2005 Jan; 79(2):910-7. PMID: 15613319.
      Citations: 50     Fields:    Translation:HumansCells
    124. Sokolskaja E, Sayah DM, Luban J. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J Virol. 2004 Dec; 78(23):12800-8. PMID: 15542632.
      Citations: 124     Fields:    Translation:HumansCells
    125. Berthoux L, Sebastian S, Sokolskaja E, Luban J. Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA. J Virol. 2004 Nov; 78(21):11739-50. PMID: 15479815.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    126. Sayah DM, Luban J. Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection. J Virol. 2004 Nov; 78(21):12066-70. PMID: 15479848.
      Citations: 23     Fields:    Translation:HumansCells
    127. Colgan J, Asmal M, Neagu M, Yu B, Schneidkraut J, Lee Y, Sokolskaja E, Andreotti A, Luban J. Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity. 2004 Aug; 21(2):189-201. PMID: 15308100.
      Citations: 80     Fields:    Translation:AnimalsCells
    128. Chen Y, Yan SS, Colgan J, Zhang HP, Luban J, Schmidt AM, Stern D, Herold KC. Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products. J Immunol. 2004 Jul 15; 173(2):1399-405. PMID: 15240736.
      Citations: 55     Fields:    Translation:AnimalsCells
    129. Sayah DM, Sokolskaja E, Berthoux L, Luban J. Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature. 2004 Jul 29; 430(6999):569-73. PMID: 15243629.
      Citations: 407     Fields:    Translation:HumansAnimalsCells
    130. Cand? C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, Luban J, Kroemer RT, Giordanetto F, Garrido C, Penninger JM, Kroemer G. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 2004 Feb 26; 23(8):1514-21. PMID: 14716299.
      Citations: 95     Fields:    Translation:HumansCells
    131. Chang F, Re F, Sebastian S, Sazer S, Luban J. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Mol Biol Cell. 2004 Apr; 15(4):1793-801. PMID: 14767062.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    132. Asmal M, Colgan J, Naef F, Yu B, Lee Y, Magnasco M, Luban J. Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK-MAPK. Immunity. 2003 Oct; 19(4):535-48. PMID: 14563318.
      Citations: 27     Fields:    Translation:AnimalsCells
    133. Towers GJ, Hatziioannou T, Cowan S, Goff SP, Luban J, Bieniasz PD. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat Med. 2003 Sep; 9(9):1138-43. PMID: 12897779.
      Citations: 217     Fields:    Translation:HumansAnimalsCells
    134. Zander K, Sherman MP, Tessmer U, Bruns K, Wray V, Prechtel AT, Schubert E, Henklein P, Luban J, Neidleman J, Greene WC, Schubert U. Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression. J Biol Chem. 2003 Oct 31; 278(44):43202-13. PMID: 12881522.
      Citations: 31     Fields:    Translation:HumansCells
    135. Berthoux L, Towers GJ, Gurer C, Salomoni P, Pandolfi PP, Luban J. As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity. J Virol. 2003 Mar; 77(5):3167-80. PMID: 12584341.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    136. Ansari H, Greco G, Luban J. Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export. Mol Cell Biol. 2002 Oct; 22(20):6993-7003. PMID: 12242280.
      Citations: 28     Fields:    Translation:AnimalsCells
    137. Zhang YJ, Hatziioannou T, Zang T, Braaten D, Luban J, Goff SP, Bieniasz PD. Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection. J Virol. 2002 Jun; 76(12):6332-43. PMID: 12021366.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    138. Gurer C, Cimarelli A, Luban J. Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. J Virol. 2002 May; 76(9):4666-70. PMID: 11932435.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    139. Luban J. HIV-1 and Ebola virus: the getaway driver nabbed. Nat Med. 2001 Dec; 7(12):1278-80. PMID: 11726960.
      Citations: 7     Fields:    Translation:Cells
    140. Cimarelli A, Luban J. Context-dependent phenotype of a human immunodeficiency virus type 1 nucleocapsid mutation. J Virol. 2001 Aug; 75(15):7193-7. PMID: 11435601.
      Citations: 2     Fields:    Translation:HumansCells
    141. Braaten D, Luban J. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells. EMBO J. 2001 Mar 15; 20(6):1300-9. PMID: 11250896.
      Citations: 140     Fields:    Translation:HumansCells
    142. Colgan J, Asmal M, Luban J. Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability. Genomics. 2000 Sep 01; 68(2):167-78. PMID: 10964515.
      Citations: 23     Fields:    Translation:AnimalsCells
    143. Cimarelli A, Luban J. Human immunodeficiency virus type 1 virion density is not determined by nucleocapsid basic residues. J Virol. 2000 Aug; 74(15):6734-40. PMID: 10888611.
      Citations: 23     Fields:    Translation:HumansCells
    144. Cimarelli A, Sandin S, H?glund S, Luban J. Rescue of multiple viral functions by a second-site suppressor of a human immunodeficiency virus type 1 nucleocapsid mutation. J Virol. 2000 May; 74(9):4273-83. PMID: 10756042.
      Citations: 16     Fields:    Translation:HumansCells
    145. Cimarelli A, Sandin S, H?glund S, Luban J. Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA. J Virol. 2000 Apr; 74(7):3046-57. PMID: 10708419.
      Citations: 119     Fields:    Translation:HumansCells
    146. Burniston MT, Cimarelli A, Colgan J, Curtis SP, Luban J. Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein. J Virol. 1999 Oct; 73(10):8527-40. PMID: 10482606.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    147. Cimarelli A, Luban J. Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein. J Virol. 1999 Jul; 73(7):5388-401. PMID: 10364286.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    148. Yin L, Braaten D, Luban J. Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels. J Virol. 1998 Aug; 72(8):6430-6. PMID: 9658084.
      Citations: 52     Fields:    Translation:HumansCells
    149. Yin L, Boussard S, Allan J, Luban J. The HIV type 1 replication block in nonhuman primates is not explained by differences in cyclophilin A primary structure. AIDS Res Hum Retroviruses. 1998 Jan 01; 14(1):95-7. PMID: 9453257.
      Citations: 8     Fields:    Translation:AnimalsCells
    150. Braaten D, Ansari H, Luban J. The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein. J Virol. 1997 Mar; 71(3):2107-13. PMID: 9032343.
      Citations: 59     Fields:    Translation:HumansCells
    151. Re F, Luban J. HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport. Prog Cell Cycle Res. 1997; 3:21-7. PMID: 9552403.
      Citations: 7     Fields:    Translation:HumansCells
    152. Luban J. Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions. Cell. 1996 Dec 27; 87(7):1157-9. PMID: 8980222.
      Citations: 52     Fields:    Translation:Cells
    153. Franke EK, Luban J. Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. Virology. 1996 Aug 01; 222(1):279-82. PMID: 8806510.
      Citations: 51     Fields:    Translation:HumansCells
    154. Braaten D, Aberham C, Franke EK, Yin L, Phares W, Luban J. Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A. J Virol. 1996 Aug; 70(8):5170-6. PMID: 8764025.
      Citations: 82     Fields:    Translation:HumansCells
    155. Braaten D, Franke EK, Luban J. Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses. J Virol. 1996 Jul; 70(7):4220-7. PMID: 8676442.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    156. Colgan J, Yuan HE, Franke EK, Luban J. Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization. J Virol. 1996 Jul; 70(7):4299-310. PMID: 8676452.
      Citations: 46     Fields:    Translation:HumansCells
    157. Braaten D, Franke EK, Luban J. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J Virol. 1996 Jun; 70(6):3551-60. PMID: 8648689.
      Citations: 162     Fields:    Translation:HumansCells
    158. Braaten D, Wellington S, Warburton D, Luban J. Assignment of cyclophilin A (PPIA) to human chromosome band 7p13by in situ hybridization. Cytogenet Cell Genet. 1996; 74(4):262. PMID: 8976380.
      Citations: 3     Fields:    Translation:HumansCells
    159. Re F, Braaten D, Franke EK, Luban J. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol. 1995 Nov; 69(11):6859-64. PMID: 7474100.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    160. Franke EK, Chen BX, Tatsis I, Diamanduros A, Erlanger BF, Luban J. Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody. J Virol. 1995 Sep; 69(9):5821-3. PMID: 7543589.
      Citations: 2     Fields:    Translation:Cells
    161. Luban J, Goff SP. The yeast two-hybrid system for studying protein-protein interactions. Curr Opin Biotechnol. 1995 Feb; 6(1):59-64. PMID: 7894083.
      Citations: 19     Fields:    Translation:Animals
    162. Reicin AS, Paik S, Berkowitz RD, Luban J, Lowy I, Goff SP. Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity. J Virol. 1995 Feb; 69(2):642-50. PMID: 7815527.
      Citations: 69     Fields:    Translation:HumansCells
    163. Franke EK, Luban J. Cyclophilin and gag in HIV-1 replication and pathogenesis. Adv Exp Med Biol. 1995; 374:217-28. PMID: 7572395.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    164. Franke EK, Yuan HE, Luban J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature. 1994 Nov 24; 372(6504):359-62. PMID: 7969494.
      Citations: 321     Fields:    Translation:HumansCells
    165. Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell. 1994 Oct 07; 79(1):119-30. PMID: 7923370.
      Citations: 227     Fields:    Translation:HumansAnimalsCells
    166. Franke EK, Yuan HE, Bossolt KL, Goff SP, Luban J. Specificity and sequence requirements for interactions between various retroviral Gag proteins. J Virol. 1994 Aug; 68(8):5300-5. PMID: 8035530.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    167. Luban J, Goff SP. Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA. J Virol. 1994 Jun; 68(6):3784-93. PMID: 8189516.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    168. Berkowitz RD, Luban J, Goff SP. Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays. J Virol. 1993 Dec; 67(12):7190-200. PMID: 8230441.
      Citations: 102     Fields:    Translation:Cells
    169. Dorfman T, Luban J, Goff SP, Haseltine WA, G?ttlinger HG. Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein. J Virol. 1993 Oct; 67(10):6159-69. PMID: 8371356.
      Citations: 159     Fields:    Translation:HumansCells
    170. Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993 Jun 18; 73(6):1067-78. PMID: 8513493.
      Citations: 362     Fields:    Translation:HumansCells
    171. Luban J, Lee C, Goff SP. Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria. J Virol. 1993 Jun; 67(6):3630-4. PMID: 8497070.
      Citations: 15     Fields:    Translation:Cells
    172. Luban J, Alin KB, Bossolt KL, Humaran T, Goff SP. Genetic assay for multimerization of retroviral gag polyproteins. J Virol. 1992 Aug; 66(8):5157-60. PMID: 1629970.
      Citations: 35     Fields:    Translation:AnimalsCells
    173. Luban J, Goff SP. Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein. J Virol. 1991 Jun; 65(6):3203-12. PMID: 2033671.
      Citations: 68     Fields:    Translation:Cells
    174. Van Voorhis WC, Valinsky J, Hoffman E, Luban J, Hair LS, Steinman RM. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med. 1983 Jul 01; 158(1):174-91. PMID: 6190976.
      Citations: 60     Fields:    Translation:HumansCells
    175. Van Voorhis WC, Steinman RM, Hair LS, Luban J, Witmer MD, Koide S, Cohn ZA. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J Exp Med. 1983 Jul 01; 158(1):126-45. PMID: 6190974.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
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