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Robert B Zurier MD

TitleProfessor Emeritus
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-6246
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionT.H. Chan School of Medicine
    DepartmentRadiology


    Collapse Biography 
    Collapse education and training
    Rutgers University Newark, Newark, NJ, United StatesBSScience
    University of Texas Southwestern Medical School, Dallas, TX, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zurier RB, Burstein SH. Cannabinoids, inflammation, and fibrosis. FASEB J. 2016 11; 30(11):3682-3689. PMID: 27435265.
      Citations: 38     Fields:    Translation:HumansAnimals
    2. Tepper MA, Zurier RB, Burstein SH. Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity. Bioorg Med Chem. 2014 Jul 01; 22(13):3245-51. PMID: 24856183.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    3. Reed GW, Leung K, Rossetti RG, Vanbuskirk S, Sharp JT, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: an 18-month, randomized, and double-blind trial. Evid Based Complement Alternat Med. 2014; 2014:857456. PMID: 24803948.
      Citations:    
    4. Olendzki BC, Leung K, Van Buskirk S, Reed G, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids. Evid Based Complement Alternat Med. 2011; 2011:827286. PMID: 22007257.
      Citations:    
    5. Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. AAPS J. 2009 Mar; 11(1):109-19. PMID: 19199042.
      Citations: 42     Fields:    Translation:HumansAnimals
    6. Zurier RB, Sun YP, George KL, Stebulis JA, Rossetti RG, Skulas A, Judge E, Serhan CN. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009 May; 23(5):1503-9. PMID: 19124557.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    7. Stebulis JA, Johnson DR, Rossetti RG, Burstein SH, Zurier RB. Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. Life Sci. 2008 Nov 07; 83(19-20):666-70. PMID: 18840450.
      Citations: 17     Fields:    Translation:Humans
    8. Han GM, O'Neil-Andersen NJ, Zurier RB, Lawrence DA. CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008 May-Jun; 253(1-2):92-101. PMID: 18649874.
      Citations: 48     Fields:    Translation:HumansCells
    9. George KL, Saltman LH, Stein GS, Lian JB, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. J Cell Physiol. 2008 Mar; 214(3):714-20. PMID: 17786950.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Parker J, Atez F, Rossetti RG, Skulas A, Patel R, Zurier RB. Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Rheumatol Int. 2008 May; 28(7):631-5. PMID: 18040689.
      Citations: 12     Fields:    Translation:HumansCells
    11. Ambrosio ALB, Dias SMG, Polikarpov I, Zurier RB, Burstein SH, Garratt RC. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007 Jun 22; 282(25):18625-18633. PMID: 17462987.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    12. Burstein SH, Adams JK, Bradshaw HB, Fraioli C, Rossetti RG, Salmonsen RA, Shaw JW, Walker JM, Zipkin RE, Zurier RB. Potential anti-inflammatory actions of the elmiric (lipoamino) acids. Bioorg Med Chem. 2007 May 15; 15(10):3345-55. PMID: 17383881.
      Citations: 19     Fields:    Translation:AnimalsCells
    13. Pedersen-Lane JH, Zurier RB, Lawrence DA. Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. J Leukoc Biol. 2007 Apr; 81(4):934-41. PMID: 17210617.
      Citations: 23     Fields:    Translation:HumansCells
    14. Johnson DR, Stebulis JA, Rossetti RG, Burstein SH, Zurier RB. Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid. J Cell Biochem. 2007 Jan 01; 100(1):184-90. PMID: 16927387.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    15. Stebulis JA, Rossetti RG, Atez FJ, Zurier RB. Fibroblast-like synovial cells derived from synovial fluid. J Rheumatol. 2005 Feb; 32(2):301-6. PMID: 15693092.
      Citations: 27     Fields:    Translation:HumansCells
    16. Burstein S, Zurier RB. Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al. Arthritis Rheum. 2004 Dec; 50(12):4078-9; author reply 4079-80. PMID: 15593192.
      Citations: 3     Fields:    Translation:HumansAnimals
    17. Burstein SH, Karst M, Schneider U, Zurier RB. Ajulemic acid: A novel cannabinoid produces analgesia without a "high". Life Sci. 2004 Aug 06; 75(12):1513-22. PMID: 15240185.
      Citations: 12     Fields:    Translation:Animals
    18. Zurier RB. Prostaglandins: then and now and next. Semin Arthritis Rheum. 2003 Dec; 33(3):137-9. PMID: 14671724.
      Citations:    Fields:    Translation:Humans
    19. Bidinger B, Torres R, Rossetti RG, Brown L, Beltre R, Burstein S, Lian JB, Stein GS, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin Immunol. 2003 Aug; 108(2):95-102. PMID: 12921755.
      Citations: 10     Fields:    Translation:HumansCells
    20. Liu J, Li H, Burstein SH, Zurier RB, Chen JD. Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. Mol Pharmacol. 2003 May; 63(5):983-92. PMID: 12695526.
      Citations: 39     Fields:    Translation:HumansCells
    21. Zurier RB. Prospects for cannabinoids as anti-inflammatory agents. J Cell Biochem. 2003 Feb 15; 88(3):462-6. PMID: 12532323.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Walker NJ, Zurier RB. Liver abnormalities in rheumatic diseases. Clin Liver Dis. 2002 Nov; 6(4):933-46. PMID: 12516200.
      Citations: 6     Fields:    Translation:Humans
    23. Burstein SH, Huang SM, Petros TJ, Rossetti RG, Walker JM, Zurier RB. Regulation of anandamide tissue levels by N-arachidonylglycine. Biochem Pharmacol. 2002 Oct 01; 64(7):1147-50. PMID: 12234618.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Furse RK, Rossetti RG, Seiler CM, Zurier RB. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. J Clin Immunol. 2002 Mar; 22(2):83-91. PMID: 11998897.
      Citations: 2     Fields:    Translation:HumansCells
    25. Furse RK, Rossetti RG, Zurier RB. Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. J Immunol. 2001 Jul 01; 167(1):490-6. PMID: 11418687.
      Citations: 13     Fields:    Translation:HumansCells
    26. Burstein SH, Rossetti RG, Yagen B, Zurier RB. Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 2000 Apr; 61(1-2):29-41. PMID: 10785540.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    27. Zurier RB, Rossetti RG, Seiler CM, Laposata M. Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun; 60(5-6):371-5. PMID: 10471124.
      Citations: 22     Fields:    Translation:HumansCells
    28. DeLuca P, Rossetti RG, Alavian C, Karim P, Zurier RB. Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. J Investig Med. 1999 May; 47(5):246-50. PMID: 10361385.
      Citations: 13     Fields:    Translation:HumansCells
    29. Zurier RB, Rossetti RG, Lane JH, Goldberg JM, Hunter SA, Burstein SH. Dimethylheptyl-THC-11 oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure. Arthritis Rheum. 1998 Jan; 41(1):163-70. PMID: 9433882.
      Citations: 23     Fields:    Translation:AnimalsCells
    30. Rothman D, Allen H, Herzog L, Pilapil A, Seiler CM, Zurier RB. Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes. Cytokine. 1997 Dec; 9(12):1008-12. PMID: 9417812.
      Citations: 2     Fields:    Translation:HumansCells
    31. Rossetti RG, Seiler CM, DeLuca P, Laposata M, Zurier RB. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol. 1997 Oct; 62(4):438-43. PMID: 9335312.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    32. Vassilopoulos D, Zurier RB, Rossetti RG, Tsokos GC. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. Clin Immunol Immunopathol. 1997 Jun; 83(3):237-44. PMID: 9175912.
      Citations: 5     Fields:    Translation:HumansCells
    33. Soscia PN, Zurier RB. Antirheumatic drug therapy during pregnancy. Bull Rheum Dis. 1997 Apr; 46(2):2-4. PMID: 9104043.
      Citations:    Fields:    Translation:Humans
    34. Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M. gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis Rheum. 1996 Nov; 39(11):1808-17. PMID: 8912502.
      Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
    35. Rothman D, DeLuca P, Zurier RB. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. Semin Arthritis Rheum. 1995 Oct; 25(2):87-96. PMID: 8578315.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    36. Rossetti RG, Seiler CM, Laposata M, Zurier RB. Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 1):220-4. PMID: 7554442.
      Citations:    Fields:    Translation:HumansCells
    37. Rossetti RG, Seiler CM, Brathwaite K, Zurier RB. Effect of Misoprostol on Acute and Chronic Inflammation. Am J Ther. 1995 Sep; 2(9):600-606. PMID: 11854833.
      Citations: 3     Fields:    
    38. Romain PL, Zurier RB, Pilapil S, Nervi A, Boucher H. Regulation of Macrophage-Independent T-Cell Activation by Prostaglandins and Nonsteroidal Anti-Inflammatory Drugs. Am J Ther. 1995 Sep; 2(9):641-647. PMID: 11854841.
      Citations:    Fields:    
    39. DeLuca P, Rothman D, Zurier RB. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 1995 Aug; 21(3):759-77. PMID: 8619098.
      Citations: 2     Fields:    Translation:HumansCells
    40. Karikó K, Rosenbaum H, Kuo A, Zurier RB, Barnathan ES. Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. FEBS Lett. 1995 Mar 13; 361(1):118-22. PMID: 7890029.
      Citations: 2     Fields:    Translation:HumansCells
    41. DeMarco DM, Santoli D, Zurier RB. Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes. J Leukoc Biol. 1994 Nov; 56(5):612-5. PMID: 7964169.
      Citations: 7     Fields:    Translation:HumansCells
    42. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with blackcurrant seed oil. Br J Rheumatol. 1994 Sep; 33(9):847-52. PMID: 8081671.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    43. Rossetti RG, Brathwaite K, Zurier RB. Suppression of acute inflammation with liposome associated prostaglandin E1. Prostaglandins. 1994 Sep; 48(3):187-95. PMID: 7809384.
      Citations: 4     Fields:    Translation:Animals
    44. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med. 1993 Nov 01; 119(9):867-73. PMID: 8214997.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    45. Zurier RB. Fatty acids, inflammation and immune responses. Prostaglandins Leukot Essent Fatty Acids. 1993 Jan; 48(1):57-62. PMID: 8424124.
      Citations: 13     Fields:    Translation:HumansCells
    46. Williams WV, Fang Q, Demarco D, VonFeldt J, Zurier RB, Weiner DB. Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J Clin Invest. 1992 Aug; 90(2):326-33. PMID: 1386608.
      Citations: 24     Fields:    Translation:HumansCells
    47. Callegari PE, Zurier RB. Botanical lipids: potential role in modulation of immunologic responses and inflammatory reactions. Rheum Dis Clin North Am. 1991 May; 17(2):415-25. PMID: 1862248.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    48. DeMarco D, Kunkel SL, Strieter RM, Basha M, Zurier RB. Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells. Biochem Biophys Res Commun. 1991 Jan 31; 174(2):411-6. PMID: 1993047.
      Citations: 8     Fields:    Translation:HumansCells
    49. Pullman-Mooar S, Laposata M, Lem D, Holman RT, Leventhal LJ, DeMarco D, Zurier RB. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Arthritis Rheum. 1990 Oct; 33(10):1526-33. PMID: 2171540.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    50. Santoli D, Phillips PD, Colt TL, Zurier RB. Suppression of interleukin 2-dependent human T cell growth in vitro by prostaglandin E (PGE) and their precursor fatty acids. Evidence for a PGE-independent mechanism of inhibition by the fatty acids. J Clin Invest. 1990 Feb; 85(2):424-32. PMID: 2298918.
      Citations: 21     Fields:    Translation:HumansCells
    51. Baker DG, Krakauer KA, Tate G, Laposata M, Zurier RB. Suppression of human synovial cell proliferation by dihomo-gamma-linolenic acid. Arthritis Rheum. 1989 Oct; 32(10):1273-81. PMID: 2553025.
      Citations: 10     Fields:    Translation:HumansCells
    52. Tate G, Mandell BF, Laposata M, Ohliger D, Baker DG, Schumacher HR, Zurier RB. Suppression of acute and chronic inflammation by dietary gamma linolenic acid. J Rheumatol. 1989 Jun; 16(6):729-34. PMID: 2550629.
      Citations: 14     Fields:    Translation:Animals
    53. Tate GA, Mandell BF, Karmali RA, Laposata M, Baker DG, Schumacher HR, Zurier RB. Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Arthritis Rheum. 1988 Dec; 31(12):1543-51. PMID: 2848532.
      Citations: 18     Fields:    Translation:Animals
    54. Bomalaski JS, Alvarez J, Touchstone J, Zurier RB. Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. Biochem Pharmacol. 1987 Oct 01; 36(19):3249-53. PMID: 3117063.
      Citations: 1     Fields:    Translation:HumansCells
    55. Bomalaski JS, Clark MA, Zurier RB. Enhanced phospholipase activity in peripheral blood monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1986 Mar; 29(3):312-8. PMID: 3964311.
      Citations: 10     Fields:    Translation:HumansCells
    56. Bomalaski JS, Clark MA, Douglas SD, Zurier RB. Enhanced phospholipase A2 and C activities of peripheral blood polymorphonuclear leukocytes from patients with rheumatoid arthritis. J Leukoc Biol. 1985 Nov; 38(5):649-54. PMID: 3862730.
      Citations: 12     Fields:    Translation:HumansCells
    57. Bomalaski JS, Williamson PK, Zurier RB. Prostaglandins and the inflammatory response. Clin Lab Med. 1983 Dec; 3(4):695-717. PMID: 6228375.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    58. Shurin SB, Cohen HJ, Whitin JC, Newburger PE. Impaired granulocyte superoxide production and prolongation of the respiratory burst due to a low-affinity NADPH-dependent oxidase. Blood. 1983 Sep; 62(3):564-71. PMID: 12566094.
      Citations: 21     Fields:    Translation:HumansCells
    59. Zurier RB, Doty J, Goldenberg A. Cyclic AMP response to prostaglandin E1 in mononuclear cells from peripheral blood and synovial fluid of patients with rheumatoid arthritis. Prostaglandins. 1977 Jan; 13(1):25-31. PMID: 190647.
      Citations: 3     Fields:    Translation:HumansCells
    60. Zurier RB, Hoffstein S, Weissmann G. Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins. Arthritis Rheum. 1973 Sep-Oct; 16(5):606-18. PMID: 4200518.
      Citations: 13     Fields:    Translation:AnimalsCells
    61. Zurier RB, Ballas M. Prostaglandin E 1 (PGE 1 ) suppression of adjuvant arthritis. Histopathology. Arthritis Rheum. 1973 Mar-Apr; 16(2):251-7. PMID: 4123764.
      Citations: 10     Fields:    Translation:Animals
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