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Robert B Zurier MD

TitleProfessor Emeritus
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-6246
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionRheumatology

    InstitutionUMMS - School of Medicine
    DepartmentRadiology


    Collapse Biography 
    Collapse education and training
    Rutgers University Newark, Newark, NJ, United StatesBSScience
    University of Texas Southwestern Medical School, Dallas, TX, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zurier RB, Burstein SH. Cannabinoids, inflammation, and fibrosis. FASEB J. 2016 Nov; 30(11):3682-3689. PMID: 27435265.
      View in: PubMed
    2. Tepper MA, Zurier RB, Burstein SH. Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity. Bioorg Med Chem. 2014 Jul 1; 22(13):3245-51. PMID: 24856183.
      View in: PubMed
    3. Reed GW, Leung K, Rossetti RG, Vanbuskirk S, Sharp JT, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: an 18-month, randomized, and double-blind trial. Evid Based Complement Alternat Med. 2014; 2014:857456. PMID: 24803948.
      View in: PubMed
    4. Olendzki BC, Leung K, Van Buskirk S, Reed G, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids. Evid Based Complement Alternat Med. 2011; 2011:827286. PMID: 22007257.
      View in: PubMed
    5. Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. AAPS J. 2009 Mar; 11(1):109-19. PMID: 19199042.
      View in: PubMed
    6. Zurier RB, Sun YP, George KL, Stebulis JA, Rossetti RG, Skulas A, Judge E, Serhan CN. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009 May; 23(5):1503-9. PMID: 19124557.
      View in: PubMed
    7. Stebulis JA, Johnson DR, Rossetti RG, Burstein SH, Zurier RB. Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells. Life Sci. 2008 Nov 7; 83(19-20):666-70. PMID: 18840450.
      View in: PubMed
    8. Han GM, O'Neil-Andersen NJ, Zurier RB, Lawrence DA. CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008 May-Jun; 253(1-2):92-101. PMID: 18649874.
      View in: PubMed
    9. George KL, Saltman LH, Stein GS, Lian JB, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells. J Cell Physiol. 2008 Mar; 214(3):714-20. PMID: 17786950.
      View in: PubMed
    10. Parker J, Atez F, Rossetti RG, Skulas A, Patel R, Zurier RB. Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Rheumatol Int. 2008 May; 28(7):631-5. PMID: 18040689.
      View in: PubMed
    11. Ambrosio AL, Dias SM, Polikarpov I, Zurier RB, Burstein SH, Garratt RC. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007 Jun 22; 282(25):18625-33. PMID: 17462987.
      View in: PubMed
    12. Burstein SH, Adams JK, Bradshaw HB, Fraioli C, Rossetti RG, Salmonsen RA, Shaw JW, Walker JM, Zipkin RE, Zurier RB. Potential anti-inflammatory actions of the elmiric (lipoamino) acids. Bioorg Med Chem. 2007 May 15; 15(10):3345-55. PMID: 17383881.
      View in: PubMed
    13. Pedersen-Lane JH, Zurier RB, Lawrence DA. Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. J Leukoc Biol. 2007 Apr; 81(4):934-41. PMID: 17210617.
      View in: PubMed
    14. Johnson DR, Stebulis JA, Rossetti RG, Burstein SH, Zurier RB. Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid. J Cell Biochem. 2007 Jan 1; 100(1):184-90. PMID: 16927387.
      View in: PubMed
    15. Stebulis JA, Rossetti RG, Atez FJ, Zurier RB. Fibroblast-like synovial cells derived from synovial fluid. J Rheumatol. 2005 Feb; 32(2):301-6. PMID: 15693092.
      View in: PubMed
    16. Burstein S, Zurier RB. Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al. Arthritis Rheum. 2004 Dec; 50(12):4078-9; author reply 4079-80. PMID: 15593192.
      View in: PubMed
    17. Burstein SH, Karst M, Schneider U, Zurier RB. Ajulemic acid: A novel cannabinoid produces analgesia without a "high". Life Sci. 2004 Aug 6; 75(12):1513-22. PMID: 15240185.
      View in: PubMed
    18. Zurier RB. Prostaglandins: then and now and next. Semin Arthritis Rheum. 2003 Dec; 33(3):137-9. PMID: 14671724.
      View in: PubMed
    19. Bidinger B, Torres R, Rossetti RG, Brown L, Beltre R, Burstein S, Lian JB, Stein GS, Zurier RB. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin Immunol. 2003 Aug; 108(2):95-102. PMID: 12921755.
      View in: PubMed
    20. Liu J, Li H, Burstein SH, Zurier RB, Chen JD. Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. Mol Pharmacol. 2003 May; 63(5):983-92. PMID: 12695526.
      View in: PubMed
    21. Zurier RB, Rossetti RG, Burstein SH, Bidinger B. Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid. Biochem Pharmacol. 2003 Feb 15; 65(4):649-55. PMID: 12566094.
      View in: PubMed
    22. Zurier RB. Prospects for cannabinoids as anti-inflammatory agents. J Cell Biochem. 2003 Feb 15; 88(3):462-6. PMID: 12532323.
      View in: PubMed
    23. Walker NJ, Zurier RB. Liver abnormalities in rheumatic diseases. Clin Liver Dis. 2002 Nov; 6(4):933-46. PMID: 12516200.
      View in: PubMed
    24. Burstein SH, Huang SM, Petros TJ, Rossetti RG, Walker JM, Zurier RB. Regulation of anandamide tissue levels by N-arachidonylglycine. Biochem Pharmacol. 2002 Oct 1; 64(7):1147-50. PMID: 12234618.
      View in: PubMed
    25. Furse RK, Rossetti RG, Seiler CM, Zurier RB. Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes. J Clin Immunol. 2002 Mar; 22(2):83-91. PMID: 11998897.
      View in: PubMed
    26. Furse RK, Rossetti RG, Zurier RB. Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. J Immunol. 2001 Jul 1; 167(1):490-6. PMID: 11418687.
      View in: PubMed
    27. Burstein SH, Rossetti RG, Yagen B, Zurier RB. Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 2000 Apr; 61(1-2):29-41. PMID: 10785540.
      View in: PubMed
    28. DeLuca P, Rossetti RG, Alavian C, Karim P, Zurier RB. Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. J Investig Med. 1999 May; 47(5):246-50. PMID: 10361385.
      View in: PubMed
    29. Zurier RB, Rossetti RG, Seiler CM, Laposata M. Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun; 60(5-6):371-5. PMID: 10471124.
      View in: PubMed
    30. Zurier RB, Rossetti RG, Lane JH, Goldberg JM, Hunter SA, Burstein SH. Dimethylheptyl-THC-11 oic acid: a nonpsychoactive antiinflammatory agent with a cannabinoid template structure. Arthritis Rheum. 1998 Jan; 41(1):163-70. PMID: 9433882.
      View in: PubMed
    31. Rothman D, Allen H, Herzog L, Pilapil A, Seiler CM, Zurier RB. Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes. Cytokine. 1997 Dec; 9(12):1008-12. PMID: 9417812.
      View in: PubMed
    32. Rossetti RG, Seiler CM, DeLuca P, Laposata M, Zurier RB. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J Leukoc Biol. 1997 Oct; 62(4):438-43. PMID: 9335312.
      View in: PubMed
    33. Vassilopoulos D, Zurier RB, Rossetti RG, Tsokos GC. Gammalinolenic acid and dihomogammalinolenic acid suppress the CD3-mediated signal transduction pathway in human T cells. Clin Immunol Immunopathol. 1997 Jun; 83(3):237-44. PMID: 9175912.
      View in: PubMed
    34. Soscia PN, Zurier RB. Antirheumatic drug therapy during pregnancy. Bull Rheum Dis. 1997 Apr; 46(2):2-4. PMID: 9104043.
      View in: PubMed
    35. Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M. gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis Rheum. 1996 Nov; 39(11):1808-17. PMID: 8912502.
      View in: PubMed
    36. Rothman D, DeLuca P, Zurier RB. Botanical lipids: effects on inflammation, immune responses, and rheumatoid arthritis. Semin Arthritis Rheum. 1995 Oct; 25(2):87-96. PMID: 8578315.
      View in: PubMed
    37. Rossetti RG, Seiler CM, Laposata M, Zurier RB. Differential regulation of human T lymphocyte protein kinase C activity by unsaturated fatty acids. Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 1):220-4. PMID: 7554442.
      View in: PubMed
    38. Rossetti RG, Seiler CM, Brathwaite K, Zurier RB. Effect of Misoprostol on Acute and Chronic Inflammation. Am J Ther. 1995 Sep; 2(9):600-606. PMID: 11854833.
      View in: PubMed
    39. Romain PL, Zurier RB, Pilapil S, Nervi A, Boucher H. Regulation of Macrophage-Independent T-Cell Activation by Prostaglandins and Nonsteroidal Anti-Inflammatory Drugs. Am J Ther. 1995 Sep; 2(9):641-647. PMID: 11854841.
      View in: PubMed
    40. DeLuca P, Rothman D, Zurier RB. Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 1995 Aug; 21(3):759-77. PMID: 8619098.
      View in: PubMed
    41. Karikó K, Rosenbaum H, Kuo A, Zurier RB, Barnathan ES. Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. FEBS Lett. 1995 Mar 13; 361(1):118-22. PMID: 7890029.
      View in: PubMed
    42. DeMarco DM, Santoli D, Zurier RB. Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes. J Leukoc Biol. 1994 Nov; 56(5):612-5. PMID: 7964169.
      View in: PubMed
    43. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with blackcurrant seed oil. Br J Rheumatol. 1994 Sep; 33(9):847-52. PMID: 8081671.
      View in: PubMed
    44. Rossetti RG, Brathwaite K, Zurier RB. Suppression of acute inflammation with liposome associated prostaglandin E1. Prostaglandins. 1994 Sep; 48(3):187-95. PMID: 7809384.
      View in: PubMed
    45. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med. 1993 Nov 1; 119(9):867-73. PMID: 8214997.
      View in: PubMed
    46. Zurier RB. Fatty acids, inflammation and immune responses. Prostaglandins Leukot Essent Fatty Acids. 1993 Jan; 48(1):57-62. PMID: 8424124.
      View in: PubMed
    47. Callegari PE, Zurier RB. Botanical lipids: potential role in modulation of immunologic responses and inflammatory reactions. Rheum Dis Clin North Am. 1991 May; 17(2):415-25. PMID: 1862248.
      View in: PubMed
    48. DeMarco D, Kunkel SL, Strieter RM, Basha M, Zurier RB. Interleukin-1 induced gene expression of neutrophil activating protein (interleukin-8) and monocyte chemotactic peptide in human synovial cells. Biochem Biophys Res Commun. 1991 Jan 31; 174(2):411-6. PMID: 1993047.
      View in: PubMed
    49. Pullman-Mooar S, Laposata M, Lem D, Holman RT, Leventhal LJ, DeMarco D, Zurier RB. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Arthritis Rheum. 1990 Oct; 33(10):1526-33. PMID: 2171540.
      View in: PubMed
    50. Santoli D, Phillips PD, Colt TL, Zurier RB. Suppression of interleukin 2-dependent human T cell growth in vitro by prostaglandin E (PGE) and their precursor fatty acids. Evidence for a PGE-independent mechanism of inhibition by the fatty acids. J Clin Invest. 1990 Feb; 85(2):424-32. PMID: 2298918.
      View in: PubMed
    51. Baker DG, Krakauer KA, Tate G, Laposata M, Zurier RB. Suppression of human synovial cell proliferation by dihomo-gamma-linolenic acid. Arthritis Rheum. 1989 Oct; 32(10):1273-81. PMID: 2553025.
      View in: PubMed
    52. Tate G, Mandell BF, Laposata M, Ohliger D, Baker DG, Schumacher HR, Zurier RB. Suppression of acute and chronic inflammation by dietary gamma linolenic acid. J Rheumatol. 1989 Jun; 16(6):729-34. PMID: 2550629.
      View in: PubMed
    53. Tate GA, Mandell BF, Karmali RA, Laposata M, Baker DG, Schumacher HR, Zurier RB. Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Arthritis Rheum. 1988 Dec; 31(12):1543-51. PMID: 2848532.
      View in: PubMed
    54. Bomalaski JS, Alvarez J, Touchstone J, Zurier RB. Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. Biochem Pharmacol. 1987 Oct 1; 36(19):3249-53. PMID: 3117063.
      View in: PubMed
    55. Bomalaski JS, Clark MA, Zurier RB. Enhanced phospholipase activity in peripheral blood monocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1986 Mar; 29(3):312-8. PMID: 3964311.
      View in: PubMed
    56. Bomalaski JS, Clark MA, Douglas SD, Zurier RB. Enhanced phospholipase A2 and C activities of peripheral blood polymorphonuclear leukocytes from patients with rheumatoid arthritis. J Leukoc Biol. 1985 Nov; 38(5):649-54. PMID: 3862730.
      View in: PubMed
    57. Bomalaski JS, Williamson PK, Zurier RB. Prostaglandins and the inflammatory response. Clin Lab Med. 1983 Dec; 3(4):695-717. PMID: 6228375.
      View in: PubMed
    58. Zurier RB, Doty J, Goldenberg A. Cyclic AMP response to prostaglandin E1 in mononuclear cells from peripheral blood and synovial fluid of patients with rheumatoid arthritis. Prostaglandins. 1977 Jan; 13(1):25-31. PMID: 190647.
      View in: PubMed
    59. Zurier RB, Hoffstein S, Weissmann G. Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins. Arthritis Rheum. 1973 Sep-Oct; 16(5):606-18. PMID: 4200518.
      View in: PubMed
    60. Zurier RB, Ballas M. Prostaglandin E 1 (PGE 1 ) suppression of adjuvant arthritis. Histopathology. Arthritis Rheum. 1973 Mar-Apr; 16(2):251-7. PMID: 4123764.
      View in: PubMed
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