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Pranoti Mandrekar PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-5391
Email
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionGastroenterology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Microbial Dynamics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
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    University of Bombay, Mumbai, MH, IndiaBSCBiochemistry
    University of Bombay, Mumbai, MH, IndiaMSCBiochemistry
    University of Bombay, Mumbai, MH, IndiaPHDApplied Biology
    Collapse awards and honors
    2012Chancellor's Award for Advancing Institution Excellence in Diversity, Univ Mass Med School
    2017Dean and Faculty Award for Outstanding Contribution to Curricular Development, Univ Mass Med School

    Collapse Overview 
    Collapse overview

    Pranoti Mandrekar, Ph.D.

    Department of Medicine

    Director, Translational Science Program
    Director, NIH Summer Research Program

    Graduate School of Biomedical Sciences

    Other Affiliation(s):

    Director, Undergraduate Medical Summer Research Program

    STRESS RESPONSES AND PROTEOSTASIS REGULATORS IN LIVER INFLAMMATION ANND FIBROSIS

    Research in my laboratory focuses on understanding the signaling mechanisms involved in innate immune cell activation during liver injury and cancer. The physiological function of the liver is elimination of pathogens and antigens from the blood for which mounting of an immune response is required. To avoid unnecessary activation of the immune system, the liver develops a local immune response followed by induction of peripheral tolerance towards the antigen. When stressful agents such as pathogens or environmental insults challenge the liver for extended periods of time and their elimination is not possible, inflammation and injury follows. The onset of inflammation in the liver is followed by fibrosis, cirrhosis and liver cancer. Thus, studying the mechanisms involved in liver inflammation will provide major insights into pathogenesis of liver disease and progression.

    Using various in vivo and in vitro models, we are studying the role of innate immune signaling pathways, their crosstalk with oxidative stress mechanisms leading to pro-inflammatory cytokine production. We are also focusing on investigating the role of chemokine responses and their effect on recruitment of bone-marrow derived cells and immune cells in the liver during development and progression of liver disease. Recent studies initiated in our lab focus on the impact of alcohol drinking on breast and liver cancer. Th main areas of focus are:

    1) Proteostasis mechanisms in fatty liver disease, inflammation and fibrosis

    Characterization of an interplay of immune and oxidative stress related mechanisms involved in mediating the effects of acute and chronic alcohol consumption, and epigenetic pathways altered in chronic liver diseases using alcoholic and non-alcoholic liver disease models are being studied. We identified a pathogenic role for stress mediated transcription factor HSF1 and its target gene, hsp90 and hsp70 in innate immune cells resulting in regulation of inflammatory responses. Using molecular and targeted translational approaches we are currently evaluating hsp90 and hsp70 as a therapeutic targets in manipulation of macrophage function in host defense and liver diseases such as alcoholic liver disease and fibrosis.

    Recently we are interested on the role of alcohol mediated proteostasis regulator, HSP90 on the microbiome and intestinal function. Extending these studies we hypothesize the role of the gut-braiin axis in progression of alcohol related liver disease. Currently we are assessing the impact of HSP90 inhibitors on the intestinal permeability and microbiome to understand the overall role of proteostasis on gut-brain-liver in alcoholic hepatitis.

    2) Chemokines and importance of immune liver cell types in liver injury

    The dynamic role of immune cells and bone marrow derived hematopoietic cells and their cross talk with other liver cell types in promoting liver diseases is being investigated. Liver macrophages, dendritic cells, NK and NKT cells play an important function in development and progression of liver disease. We propose to unravel the role of chemokinesin recruitment of immune cells in the liver and modulate chronic liver injury. Specifically, studies from our laboratory have identified a significant role for a CC-chemokine, monocyte chemoattractant protein -1 (MCP-1) in induction of fatty liver disease. We hypothesize that CCL2 is an important link between innate immune mechanisms and steatosis or fatty liver. Other chemokines and chemokine receptors are also being explored to determine the role of MCP-1 in mediating inflammatory processes leading to alcoholic liver injury.

    3) Impact of binge/moderate alcohol on immune response

    Acute/moderate alcohol consumption alters innate and adaptive immune function reducing host defense including antibacterial, anti-viral and tissue repair and predisposing to infections and trauma contributing to impairment of health. Studies addressing mechanisms associated with moderate alcohol induced immune suppression leading to increased susceptibility if infections and trauma are limited leaving the clinician with no therapeutics to rectify altered immune function. To date no studies have identified signaling proteins that can be potentially developed as therapeutic targets in alcohol induced immune effects. Understanding the mechanisms linked to acute/moderate alcohol induced immune suppression will thus provide insight into the molecular pathogenesis of interactions of host defense and alcohol and also extend our horizons to identify therapeutic targets to restore normal immune function. Results from our studies will also have a broader applicability to the understanding of the molecular mechanisms affected by alcohol use with relation to multiple organs including the cardiovascular system, lung and liver. More importantly, these studies will answer a biologically highly relevant question at the cellular level and help identify novel therapeutic molecular targets for restoration of normal innate immune responses.

     

     

     


    Collapse Rotation Projects

    Potential Rotation Projects

    1. Expression and function of proteostasis regulators, HSF1, hsp70 and hsp90 in liver disease: Determine the expression and function in different cell types of the liver during acute and chronic liver injury using in vivo and in vitro models. Subsequently, we will test the relevance of the expression of these proteins in activation of intracellular signaling molecules involved in induction of fatty liver, inflammation and fibrosis.
    2. Role of MCP-1 in induction of fatty liver disease: CC-chemokines particularly CCL2/MCP-1, is significantly increased in serum as well as in the liver parenchyma in patients with alcoholic hepatitis. We will test the role of MCP-1 in induction of fatty acid synthesis or metabolism in the alcoholic liver. Our studies will also investigate the role of MCP-1 directed migration of immune cells in the liver contributing to injury.


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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singal AK, Kwo P, Kwong A, Liangpunsakul S, Louvet A, Mandrekar P, McClain C, Mellinger J, Szabo G, Terrault N, Thursz M, Winder GS, Kim WR, Shah VH. Research methodologies to address clinical unmet needs and challenges in alcohol-associated liver disease. Hepatology. 2022 04; 75(4):1026-1037. PMID: 34496071.
      Citations:    Fields:    Translation:Humans
    2. Moon AM, Curtis B, Mandrekar P, Singal AK, Verna EC, Fix OK. Alcohol-Associated Liver Disease Before and After COVID-19-An Overview and Call for Ongoing Investigation. Hepatol Commun. 2021 Sep; 5(9):1616-1621. PMID: 34510833.
      Citations: 1     Fields:    
    3. Ratna A, Lim A, Li Z, Argemi J, Bataller R, Chiosis G, Mandrekar P. Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol-Associated Liver Disease. Hepatol Commun. 2021 Jul; 5(7):1165-1182. PMID: 34278167.
      Citations: 1     Fields:    
    4. Bansal R, Mandrekar P, Mohanty SK, Weiskirchen R. Editorial: Macrophages in Liver Disease. Front Immunol. 2020; 11:1754. PMID: 32849626.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Choudhury A, Bullock D, Lim A, Argemi J, Orning P, Lien E, Bataller R, Mandrekar P. Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury. Alcohol Clin Exp Res. 2020 06; 44(6):1300-1311. PMID: 32282939.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    6. McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJ. Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol. 2020 09; 87:89-95. PMID: 32353591.
      Citations: 2     Fields:    Translation:Humans
    7. Mandrekar P. Targeting Epigenetic Mechanisms to Alleviate Alcoholic Steatosis. Cell Mol Gastroenterol Hepatol. 2020; 9(4):713-714. PMID: 32097606.
      Citations:    Fields:    Translation:Humans
    8. King JA, Nephew BC, Choudhury A, Poirier GL, Lim A, Mandrekar P. Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation. Alcohol. 2020 03; 83:75-81. PMID: 31398460.
      Citations: 3     Fields:    Translation:Animals
    9. Fulham MA, Ratna A, Gerstein RM, Kurt-Jones EA, Mandrekar P. Alcohol-induced adipose tissue macrophage phenotypic switching is independent of myeloid Toll-like receptor 4 expression. Am J Physiol Cell Physiol. 2019 10 01; 317(4):C687-C700. PMID: 31268779.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Br├╝ggenwirth IMA, Moore C, Mahboub P, Thijssen MF, E X, Leuvenink HGD, Mandrekar P, Wang X, Kowalik TF, Porte RJ, Martins PN. A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation. Transplant Direct. 2018 Nov; 4(11):e400. PMID: 30534591.
      Citations:    
    11. Kuprys PV, Tsukamoto H, Gao B, Jia L, McGowan J, Coopersmith CM, Moreno MC, Hulsebus H, Meena AS, Souza-Smith FM, Roper P, Foster MT, Raju SV, Marshall SA, Fujita M, Curtis BJ, Wyatt TA, Mandrekar P, Kovacs EJ, Choudhry MA. Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2019 06; 77:11-18. PMID: 30763905.
      Citations: 2     Fields:    Translation:HumansAnimals
    12. Mandrekar P, Cardinale V. Periostin and mesothelin: Potential predictors of malignant progression in intrahepatic cholangiocarcinoma. Hepatol Commun. 2018 May; 2(5):481-483. PMID: 29761164.
      Citations:    Fields:    
    13. Muralidharan S, Lim A, Catalano D, Mandrekar P. Human Binge Alcohol Intake Inhibits TLR4-MyD88 and TLR4-TRIF Responses but Not the TLR3-TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles. J Immunol. 2018 04 01; 200(7):2291-2303. PMID: 29445009.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    14. Ratna A, Mandrekar P. Alcohol and Cancer: Mechanisms and Therapies. Biomolecules. 2017 08 14; 7(3). PMID: 28805741.
      Citations: 29     Fields:    Translation:HumansAnimals
    15. Mandrekar P. Advancing hepatology research: Excellence in open access. Hepatol Commun. 2017 04; 1(2):83. PMID: 29404446.
      Citations:    Fields:    
    16. Fulham MA, Mandrekar P. Sexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury. PLoS One. 2016; 11(10):e0164225. PMID: 27711160.
      Citations: 25     Fields:    Translation:Animals
    17. Cannon AR, Morris NL, Hammer AM, Curtis B, Remick DG, Yeligar SM, Poole L, Burnham EL, Wyatt TA, Molina PE, So-Armah K, Cisneros T, Wang G, Lang CH, Mandrekar P, Kovacs EJ, Choudhry MA. Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2016 08; 54:73-7. PMID: 27522326.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Mandrekar P, Bataller R, Tsukamoto H, Gao B. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. 2016 10; 64(4):1343-55. PMID: 26940353.
      Citations: 45     Fields:    Translation:HumansAnimals
    19. Hammer AM, Morris NL, Cannon AR, Shults JA, Curtis B, Casey CA, Sueblinvong V, Persidsky Y, Nixon K, Brown LA, Waldschmidt T, Mandrekar P, Kovacs EJ, Choudhry MA. Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2015 Dec; 49(8):767-72. PMID: 26520175.
      Citations:    Fields:    Translation:HumansAnimalsCells
    20. Bataller R, Mandrekar P. Identifying molecular targets to improve immune function in alcoholic hepatitis. Gastroenterology. 2015 Mar; 148(3):498-501. PMID: 25613314.
      Citations: 5     Fields:    Translation:Humans
    21. Ju C, Mandrekar P. Macrophages and Alcohol-Related Liver Inflammation. Alcohol Res. 2015; 37(2):251-62. PMID: 26717583.
      Citations: 37     Fields:    Translation:HumansCells
    22. Morris NL, Ippolito JA, Curtis BJ, Chen MM, Friedman SL, Hines IN, Haddad GE, Chang SL, Brown LA, Waldschmidt TJ, Mandrekar P, Kovacs EJ, Choudhry MA. Alcohol and inflammatory responses: summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2015 Feb; 49(1):1-6. PMID: 25468277.
      Citations: 10     Fields:    Translation:HumansAnimals
    23. Muralidharan S, Ambade A, Fulham MA, Deshpande J, Catalano D, Mandrekar P. Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance. J Immunol. 2014 Aug 15; 193(4):1975-87. PMID: 25024384.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    24. Ambade A, Catalano D, Lim A, Kopoyan A, Shaffer SA, Mandrekar P. Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. J Hepatol. 2014 Oct; 61(4):903-11. PMID: 24859453.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    25. Mandrekar P, Ambade A. Immunity and inflammatory signaling in alcoholic liver disease. Hepatol Int. 2014 Sep; 8 Suppl 2:439-46. PMID: 26201323.
      Citations: 6     Fields:    
    26. Muralidharan S, Mandrekar P. Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation. J Leukoc Biol. 2013 Dec; 94(6):1167-84. PMID: 23990626.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    27. Ambade A, Catalano D, Lim A, Mandrekar P. Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice. Hepatology. 2012 May; 55(5):1585-95. PMID: 22105779.
      Citations: 32     Fields:    Translation:AnimalsCells
    28. Ambade A, Mandrekar P. Oxidative stress and inflammation: essential partners in alcoholic liver disease. Int J Hepatol. 2012; 2012:853175. PMID: 22500241.
      Citations:    
    29. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011 Dec; 54(6):2185-97. PMID: 21826694.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    30. Mandrekar P. Epigenetic regulation in alcoholic liver disease. World J Gastroenterol. 2011 May 28; 17(20):2456-64. PMID: 21633650.
      Citations: 45     Fields:    Translation:Humans
    31. Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D, Mandrekar P, Szabo G. Hepatocyte-specific hypoxia-inducible factor-1? is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology. 2011 May; 53(5):1526-37. PMID: 21520168.
      Citations: 93     Fields:    Translation:AnimalsCells
    32. Szabo G, Mandrekar P, Petrasek J, Catalano D. The unfolding web of innate immune dysregulation in alcoholic liver injury. Alcohol Clin Exp Res. 2011 May; 35(5):782-6. PMID: 21284666.
      Citations: 43     Fields:    Translation:HumansAnimals
    33. Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, Lippai D, Catalano D, Mandrekar P, Dolganiuc A, Kurt-Jones E, Szabo G. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Mar; 300(3):G433-41. PMID: 21233280.
      Citations: 106     Fields:    Translation:AnimalsCells
    34. Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, Kodys K, Catalano D, Kurt-Jones E, Mandrekar P, Szabo G. Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology. 2011 Feb; 53(2):649-60. PMID: 21274885.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    35. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011 Jan 14; 286(2):1436-44. PMID: 21062749.
      Citations: 191     Fields:    Translation:AnimalsCells
    36. Petrasek J, Mandrekar P, Szabo G. Toll-like receptors in the pathogenesis of alcoholic liver disease. Gastroenterol Res Pract. 2010; 2010. PMID: 20827314.
      Citations:    
    37. Szabo G, Mandrekar P. Focus on: Alcohol and the liver. Alcohol Res Health. 2010; 33(1-2):87-96. PMID: 23579939.
      Citations: 14     Fields:    Translation:HumansAnimals
    38. Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res. 2009 Oct; 33(10):1704-10. PMID: 19572984.
      Citations: 87     Fields:    Translation:Animals
    39. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol. 2009 Jul 15; 183(2):1320-7. PMID: 19561104.
      Citations: 107     Fields:    Translation:HumansCells
    40. Mandrekar P, Szabo G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol. 2009 Jun; 50(6):1258-66. PMID: 19398236.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    41. Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, Mandrekar P, Szabo G. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology. 2009 Mar; 49(3):989-97. PMID: 19115316.
      Citations: 100     Fields:    Translation:AnimalsCells
    42. Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res. 2009 Feb; 33(2):220-32. PMID: 19053973.
      Citations: 157     Fields:    Translation:HumansAnimals
    43. Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology. 2008 Oct; 48(4):1224-31. PMID: 18792393.
      Citations: 199     Fields:    Translation:AnimalsCells
    44. Hritz I, Velayudham A, Dolganiuc A, Kodys K, Mandrekar P, Kurt-Jones E, Szabo G. Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion. Hepatology. 2008 Oct; 48(4):1342-7. PMID: 18798338.
      Citations: 17     Fields:    Translation:AnimalsCells
    45. Mandrekar P, Catalano D, Jeliazkova V, Kodys K. Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation. J Leukoc Biol. 2008 Nov; 84(5):1335-45. PMID: 18689673.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    46. Norkina O, Dolganiuc A, Catalano D, Kodys K, Mandrekar P, Syed A, Efros M, Szabo G. Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes. Alcohol Clin Exp Res. 2008 Sep; 32(9):1565-73. PMID: 18616672.
      Citations: 41     Fields:    Translation:HumansCells
    47. Szabo G, Mandrekar P. Human monocytes, macrophages, and dendritic cells: alcohol treatment methods. Methods Mol Biol. 2008; 447:113-24. PMID: 18369915.
      Citations: 11     Fields:    Translation:HumansCells
    48. Szabo G, Mandrekar P, Dolganiuc A. Innate immune response and hepatic inflammation. Semin Liver Dis. 2007 Nov; 27(4):339-50. PMID: 17979071.
      Citations: 77     Fields:    Translation:HumansAnimals
    49. Mandrekar P. Signaling mechanisms in alcoholic liver injury: role of transcription factors, kinases and heat shock proteins. World J Gastroenterol. 2007 Oct 07; 13(37):4979-85. PMID: 17854141.
      Citations: 7     Fields:    Translation:HumansCells
    50. Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C, Mandrekar P, Szabo G. Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology. 2007 Nov; 133(5):1627-36. PMID: 17916356.
      Citations: 92     Fields:    Translation:HumansCells
    51. Szabo G, Mandrekar P, Oak S, Mayerle J. Effect of ethanol on inflammatory responses. Implications for pancreatitis. Pancreatology. 2007; 7(2-3):115-23. PMID: 17592223.
      Citations: 26     Fields:    Translation:HumansCells
    52. Mandrekar P, Jeliazkova V, Catalano D, Szabo G. Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes. J Immunol. 2007 Jun 15; 178(12):7686-93. PMID: 17548605.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    53. Norkina O, Dolganiuc A, Shapiro T, Kodys K, Mandrekar P, Szabo G. Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J Leukoc Biol. 2007 Sep; 82(3):752-62. PMID: 17575268.
      Citations: 40     Fields:    Translation:HumansCells
    54. Dolganiuc A, Chang S, Kodys K, Mandrekar P, Bakis G, Cormier M, Szabo G. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol. 2006 Nov 15; 177(10):6758-68. PMID: 17082589.
      Citations: 97     Fields:    Translation:HumansCells
    55. Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G. Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol. 2006 Aug 15; 177(4):2592-600. PMID: 16888021.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    56. Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology. 2006 Aug; 44(2):287-98. PMID: 16871558.
      Citations: 76     Fields:    Translation:HumansAnimals
    57. Velayudham A, Hritz I, Dolganiuc A, Mandrekar P, Kurt-Jones E, Szabo G. Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. J Hepatol. 2006 Dec; 45(6):813-24. PMID: 16935388.
      Citations: 22     Fields:    Translation:Animals
    58. Oak S, Mandrekar P, Catalano D, Kodys K, Szabo G. TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J Immunol. 2006 Jun 15; 176(12):7628-35. PMID: 16751410.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    59. Crews FT, Bechara R, Brown LA, Guidot DM, Mandrekar P, Oak S, Qin L, Szabo G, Wheeler M, Zou J. Cytokines and alcohol. Alcohol Clin Exp Res. 2006 Apr; 30(4):720-30. PMID: 16573591.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    60. Mandrekar P, Catalano D, White B, Szabo G. Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10. Alcohol Clin Exp Res. 2006 Jan; 30(1):135-9. PMID: 16433741.
      Citations: 58     Fields:    Translation:HumansCells
    61. Dolganiuc A, Bakis G, Kodys K, Mandrekar P, Szabo G. Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts. Alcohol Clin Exp Res. 2006 Jan; 30(1):76-85. PMID: 16433734.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    62. Szabo G, Velayudham A, Romics L, Mandrekar P. Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):140S-145S. PMID: 16344599.
      Citations: 69     Fields:    Translation:Animals
    63. Romics L, Dolganiuc A, Velayudham A, Kodys K, Mandrekar P, Golenbock D, Kurt-Jones E, Szabo G. Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes. J Leukoc Biol. 2005 Dec; 78(6):1255-64. PMID: 16204620.
      Citations: 12     Fields:    Translation:AnimalsCells
    64. Mandrekar P, Pruett S, Arteel G, Thiele G, Szabo G. RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage. Alcohol Clin Exp Res. 2005 Sep; 29(9):1744-8. PMID: 16205375.
      Citations:    Fields:    Translation:HumansAnimals
    65. Szabo G, Weinman SA, Gao B, Polyak SJ, Mandrekar P, Thiele GM. RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease. Alcohol Clin Exp Res. 2005 Sep; 29(9):1753-7. PMID: 16205377.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    66. Hoek J, Thiele GM, Klassen LW, Mandrekar P, Zakhari S, Cook RT, Ray NB, Happel KI, Kolls JK, Kovacs EJ, Szab G. RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage. Alcohol Clin Exp Res. 2005 Sep; 29(9):1735-43. PMID: 16205374.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    67. Romics L, Mandrekar P, Kodys K, Velayudham A, Drechsler Y, Dolganiuc A, Szabo G. Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression. Alcohol Clin Exp Res. 2005 Jun; 29(6):1018-26. PMID: 15976528.
      Citations: 11     Fields:    Translation:Animals
    68. Romics L, Dolganiuc A, Kodys K, Drechsler Y, Oak S, Velayudham A, Mandrekar P, Szabo G. Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology. 2004 Sep; 40(3):555-64. PMID: 15349893.
      Citations: 26     Fields:    Translation:AnimalsCells
    69. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G. Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J Immunol. 2004 Sep 01; 173(5):3398-407. PMID: 15322204.
      Citations: 42     Fields:    Translation:HumansCells
    70. Romics L, Kodys K, Dolganiuc A, Graham L, Velayudham A, Mandrekar P, Szabo G. Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver. Hepatology. 2004 Aug; 40(2):376-85. PMID: 15368442.
      Citations: 20     Fields:    Translation:AnimalsCells
    71. Szabo G, Dolganiuc A, Mandrekar P, White B. Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection. Alcohol. 2004 Jul; 33(3):241-9. PMID: 15596093.
      Citations: 20     Fields:    Translation:HumansCells
    72. Szabo G, Catalano D, White B, Mandrekar P. Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res. 2004 May; 28(5):824-8. PMID: 15166660.
      Citations: 32     Fields:    Translation:HumansCells
    73. Dolganiuc A, Kodys K, Kopasz A, Marshall C, Mandrekar P, Szabo G. Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction. Alcohol Clin Exp Res. 2003 Jun; 27(6):1023-31. PMID: 12824825.
      Citations: 25     Fields:    Translation:HumansCells
    74. Dolganiuc A, Kodys K, Kopasz A, Marshall C, Do T, Romics L, Mandrekar P, Zapp M, Szabo G. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol. 2003 Jun 01; 170(11):5615-24. PMID: 12759441.
      Citations: 76     Fields:    Translation:HumansCells
    75. Mandrekar P, Bellerose G, Szabo G. Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes. Alcohol Clin Exp Res. 2002 Dec; 26(12):1872-9. PMID: 12500112.
      Citations: 6     Fields:    Translation:HumansCells
    76. Mandrekar P, Dolganiuc A, Bellerose G, Kodys K, Romics L, Nizamani R, Szabo G. Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation? Alcohol Clin Exp Res. 2002 Nov; 26(11):1609-14. PMID: 12436048.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    77. Drechsler Y, Chavan S, Catalano D, Mandrekar P, Szabo G. FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development. J Leukoc Biol. 2002 Oct; 72(4):657-67. PMID: 12377934.
      Citations: 6     Fields:    Translation:HumansCells
    78. Szabo G, Mandrekar P. Ethanol-mediated regulation of transcription factors in immunocompetent cells. Front Biosci. 2002 May 01; 7:a80-9. PMID: 11991856.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    79. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K. Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Alcohol Clin Exp Res. 2001 Dec; 25(12):1766-72. PMID: 11781510.
      Citations: 19     Fields:    Translation:HumansCells
    80. Szabo G, Gavala C, Mandrekar P. Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells. J Investig Med. 2001 Sep; 49(5):442-9. PMID: 11523700.
      Citations: 20     Fields:    Translation:HumansCells
    81. Szabo G, Catalano D, Bellerose G, Mandrekar P. Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production. Alcohol Clin Exp Res. 2001 Aug; 25(8):1188-97. PMID: 11505050.
      Citations: 5     Fields:    Translation:HumansCells
    82. Mandrekar P, Catalano D, Szabo G. Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes. Int Immunol. 1999 Nov; 11(11):1781-90. PMID: 10545482.
      Citations: 31     Fields:    Translation:HumansCells
    83. Szabo G, Chavan S, Mandrekar P, Catalano D. Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation. J Clin Immunol. 1999 Jan; 19(1):67-76. PMID: 10080106.
      Citations: 29     Fields:    Translation:HumansCells
    84. Szabo G, Girouard L, Mandrekar P, Catalano D. Regulation of monocyte IL-12 production: augmentation by lymphocyte contact and acute ethanol treatment, inhibition by elevated intracellular cAMP. Int J Immunopharmacol. 1998 Sep; 20(9):491-503. PMID: 9818793.
      Citations: 6     Fields:    Translation:HumansCells
    85. Girouard L, Mandrekar P, Catalano D, Szabo G. Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10. Alcohol Clin Exp Res. 1998 Feb; 22(1):211-6. PMID: 9514309.
      Citations: 3     Fields:    Translation:HumansCells
    86. Mandrekar P, Catalano D, Szabo G. Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes. Alcohol Clin Exp Res. 1997 Sep; 21(6):988-94. PMID: 9309306.
      Citations: 19     Fields:    Translation:HumansCells
    87. Szabo G, Girouard L, Mandrekar P, Catalano D. Acute ethanol treatment augments interleukin-12 production in activated human monocytes. Ann N Y Acad Sci. 1996 Oct 31; 795:422-5. PMID: 8958973.
      Citations: 4     Fields:    Translation:HumansCells
    88. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res. 1996 Aug; 20(5):900-7. PMID: 8865966.
      Citations: 60     Fields:    Translation:HumansCells
    89. Mandrekar P, Catalano D, Girouard L, Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine. 1996 Jul; 8(7):567-77. PMID: 8891438.
      Citations: 13     Fields:    Translation:HumansCells
    90. Szabo G, Mandrekar P, Catalano D. Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment. J Leukoc Biol. 1995 Sep; 58(3):342-50. PMID: 7665990.
      Citations: 21     Fields:    Translation:HumansCells
    91. Szabo G, Mandrekar P, Verma B, Isaac A, Catalano D. Acute ethanol consumption synergizes with trauma to increase monocyte tumor necrosis factor alpha production late postinjury. J Clin Immunol. 1994 Nov; 14(6):340-52. PMID: 7883861.
      Citations: 12     Fields:    Translation:HumansCells
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