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Kristen L Billiar PhD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentSurgery
AddressWorcester Polytechnic Institute
100 Institute Road
Worcester MA 01609
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentSurgery
    DivisionPlastic Surgery


    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NY, United StatesBSMechanical Engineering
    University of Pennsylvania, Philadelphia, PA, United StatesMSBioengineering
    University of Pennsylvania, Philadelphia, PA, United StatesPHDBioengineering

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yu H, Tang D, Geva T, Yang C, Wu Z, Rathod RH, Huang X, Billiar KL, Del Nido PJ. Ventricle stress/strain comparisons between Tetralogy of Fallot patients and healthy using models with different zero-load diastole and systole morphologies. PLoS One. 2019; 14(8):e0220328. PMID: 31412062.
      View in: PubMed
    2. Wang Q, Tang D, Wang L, Canton G, Wu Z, Hatsukami TS, Billiar KL, Yuan C. Combining morphological and biomechanical factors for optimal carotid plaque progression prediction: An MRI-based follow-up study using 3D thin-layer models. Int J Cardiol. 2019 Jul 04. PMID: 31301863.
      View in: PubMed
    3. Yu H, Del Nido PJ, Geva T, Yang C, Tang A, Wu Z, Rathod RH, Huang X, Billiar KL, Tang D. Patient-specific in vivo right ventricle material parameter estimation for patients with tetralogy of Fallot using MRI-based models with different zero-load diastole and systole morphologies. Int J Cardiol. 2018 Sep 10. PMID: 30217422.
      View in: PubMed
    4. Wang L, Tang D, Maehara A, Wu Z, Yang C, Muccigrosso D, Zheng J, Bach R, Billiar KL, Mintz GS. Fluid-structure interaction models based on patient-specific IVUS at baseline and follow-up for prediction of coronary plaque progression by morphological and biomechanical factors: A preliminary study. J Biomech. 2018 Feb 08; 68:43-50. PMID: 29274686.
      View in: PubMed
    5. Dutta S, Mana-Capelli S, Paramasivam M, Dasgupta I, Cirka H, Billiar K, McCollum D. TRIP6 inhibits Hippo signaling in response to tension at adherens junctions. EMBO Rep. 2018 Feb; 19(2):337-350. PMID: 29222344.
      View in: PubMed
    6. Hoffman AH, Teng Z, Zheng J, Wu Z, Woodard PK, Billiar KL, Wang L, Tang D. Stiffness Properties of Adventitia, Media, and Full Thickness Human Atherosclerotic Carotid Arteries in the Axial and Circumferential Directions. J Biomech Eng. 2017 Dec 01; 139(12). PMID: 28857112.
      View in: PubMed
    7. Wang Q, Canton G, Guo J, Guo X, Hatsukami TS, Billiar KL, Yuan C, Wu Z, Tang D. MRI-based patient-specific human carotid atherosclerotic vessel material property variations in patients, vessel location and long-term follow up. PLoS One. 2017; 12(7):e0180829. PMID: 28715441.
      View in: PubMed
    8. DueƱas-Garcia OF, Sullivan GM, Leung K, Billiar KL, Flynn MK. Knot integrity using different suture types and different knot-tying techniques for reconstructive pelvic floor procedures. Int Urogynecol J. 2017 Jun 20. PMID: 28634623.
      View in: PubMed
    9. Billiar KL, Kennedy E. Biomechanics Education Redux. J Biomech Eng. 2017 May 11. PMID: 28494057.
      View in: PubMed
    10. Cirka HA, Uribe J, Liang V, Schoen FJ, Billiar KL. Reproducible in vitro model for dystrophic calcification of cardiac valvular interstitial cells: insights into the mechanisms of calcific aortic valvular disease. Lab Chip. 2017 Feb 28; 17(5):814-829. PMID: 28128382.
      View in: PubMed
    11. Tang D, Zuo H, Yang C, Wu Z, Huang X, Rathod RH, Tang A, Billiar KL, Geva T. Comparison of Right Ventricle Morphological and Mechanical Characteristics for Healthy and Patients with Tetralogy of Fallot: An In Vivo MRI-Based Modeling Study. Mol Cell Biomech. 2017; 14(3):137-151. PMID: 30147632.
      View in: PubMed
    12. Aghvami M, Billiar KL, Sander EA. Fiber Network Models Predict Enhanced Cell Mechanosensing on Fibrous Gels. J Biomech Eng. 2016 Oct 01; 138(10). PMID: 27548709.
      View in: PubMed
    13. Tang D, Del Nido PJ, Yang C, Zuo H, Huang X, Rathod RH, Gooty V, Tang A, Wu Z, Billiar KL, Geva T. Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions. PLoS One. 2016; 11(9):e0162986. PMID: 27627806.
      View in: PubMed
    14. Guo X, Zhu J, Maehara A, Monoly D, Samady H, Wang L, Billiar KL, Zheng J, Yang C, Mintz GS, Giddens DP, Tang D. Quantify patient-specific coronary material property and its impact on stress/strain calculations using in vivo IVUS data and 3D FSI models: a pilot study. Biomech Model Mechanobiol. 2017 Feb; 16(1):333-344. PMID: 27561649.
      View in: PubMed
    15. Billiar K. Special Section: Annual Education Issue: Let the Wild Rumpus of Education Start! J Biomech Eng. 2016 Jul 1; 138(7). PMID: 27165159.
      View in: PubMed
    16. Clyne AM, Billiar KL. Problem-Based Learning in Biomechanics: Advantages, Challenges, and Implementation Strategies. J Biomech Eng. 2016 Jul 1; 138(7). PMID: 27210616.
      View in: PubMed
    17. Cirka H, Monterosso M, Diamantides N, Favreau J, Wen Q, Billiar K. Active Traction Force Response to Long-Term Cyclic Stretch Is Dependent on Cell Pre-stress. Biophys J. 2016 Apr 26; 110(8):1845-57. PMID: 27119644.
      View in: PubMed
    18. Kural MH, Billiar KL. Myofibroblast persistence with real-time changes in boundary stiffness. Acta Biomater. 2016 Mar 01; 32:223-30. PMID: 26712600.
      View in: PubMed
    19. Wang L, Zheng J, Maehara A, Yang C, Billiar KL, Wu Z, Bach R, Muccigrosso D, Mintz GS, Tang D. Morphological and Stress Vulnerability Indices for Human Coronary Plaques and Their Correlations with Cap Thickness and Lipid Percent: An IVUS-Based Fluid-Structure Interaction Multi-patient Study. PLoS Comput Biol. 2015 Dec; 11(12):e1004652. PMID: 26650721.
      View in: PubMed
    20. Tang D, Yang C, del Nido PJ, Zuo H, Rathod RH, Huang X, Gooty V, Tang A, Billiar KL, Wu Z, Geva T. Mechanical stress is associated with right ventricular response to pulmonary valve replacement in patients with repaired tetralogy of Fallot. J Thorac Cardiovasc Surg. 2016 Mar; 151(3):687-94.e1-3. PMID: 26548998.
      View in: PubMed
    21. Zhang W, Feng Y, Lee CH, Billiar KL, Sacks MS. A generalized method for the analysis of planar biaxial mechanical data using tethered testing configurations. J Biomech Eng. 2015 Jun; 137(6):064501. PMID: 25429606.
      View in: PubMed
    22. Mullen CA, Vaughan TJ, Billiar KL, McNamara LM. The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior. Biophys J. 2015 Apr 7; 108(7):1604-12. PMID: 25863052.
      View in: PubMed
    23. Cirka HA, Kural MH, Billiar KL. Mechanoregulation of aortic valvular interstitial cell life and death. J Long Term Eff Med Implants. 2015; 25(1-2):3-16. PMID: 25955003.
      View in: PubMed
    24. Wang L, Wu Z, Yang C, Zheng J, Bach R, Muccigrosso D, Billiar K, Maehara A, Mintz GS, Tang D. IVUS-based FSI models for human coronary plaque progression study: components, correlation and predictive analysis. Ann Biomed Eng. 2015 Jan; 43(1):107-21. PMID: 25245219.
      View in: PubMed
    25. Fan R, Tang D, Yang C, Zheng J, Bach R, Wang L, Muccigrosso D, Billiar K, Zhu J, Ma G, Maehara A, Mintz GS. Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an IVUS-based fluid-structure interaction multi-patient study. Biomed Eng Online. 2014 Mar 26; 13(1):32. PMID: 24669780.
      View in: PubMed
    26. Kural MH, Billiar KL. Mechanoregulation of valvular interstitial cell phenotype in the third dimension. Biomaterials. 2014 Jan; 35(4):1128-37. PMID: 24210873.
      View in: PubMed
    27. Kural MH, Billiar KL. Regulating tension in three-dimensional culture environments. Exp Cell Res. 2013 Oct 1; 319(16):2447-59. PMID: 23850829.
      View in: PubMed
    28. Rudnicki MS, Cirka HA, Aghvami M, Sander EA, Wen Q, Billiar KL. Nonlinear strain stiffening is not sufficient to explain how far cells can feel on fibrous protein gels. Biophys J. 2013 Jul 2; 105(1):11-20. PMID: 23823219.
      View in: PubMed
    29. Tang D, Yang C, Geva T, Rathod R, Yamauchi H, Gooty V, Tang A, Kural MH, Billiar KL, Gaudette G, Del Nido PJ. A Multiphysics Modeling Approach to Develop Right Ventricle Pulmonary Valve Replacement Surgical Procedures with a Contracting Band to Improve Ventricle Ejection Fraction. Comput Struct. 2013 Jun 1; 122:78-87. PMID: 23667272.
      View in: PubMed
    30. Tang D, Yang C, Zheng J, Canton G, Bach RG, Hatsukami TS, Wang L, Yang D, Billiar KL, Yuan C. Image-based modeling and precision medicine: patient-specific carotid and coronary plaque assessment and predictions. IEEE Trans Biomed Eng. 2013 Mar; 60(3):643-51. PMID: 23362245.
      View in: PubMed
    31. Adebayo O, Hookway TA, Hu JZ, Billiar KL, Rolle MW. Self-assembled smooth muscle cell tissue rings exhibit greater tensile strength than cell-seeded fibrin or collagen gel rings. J Biomed Mater Res A. 2013 Feb; 101(2):428-37. PMID: 22865465.
      View in: PubMed
    32. Quinlan AM, Billiar KL. Investigating the role of substrate stiffness in the persistence of valvular interstitial cell activation. J Biomed Mater Res A. 2012 Sep; 100(9):2474-82. PMID: 22581728.
      View in: PubMed
    33. Yang C, Tang D, Geva T, Rathod R, Yamauchi H, Gooty V, Tang A, Gaudette G, Billiar KL, Kural MH, del Nido PJ. Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventricles. J Thorac Cardiovasc Surg. 2013 Jan; 145(1):285-93, 293.e1-2. PMID: 22487437.
      View in: PubMed
    34. Liu H, Cai M, Yang C, Zheng J, Bach R, Kural MH, Billiar KL, Muccigrosso D, Lu D, Tang D. IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment. Mol Cell Biomech. 2012 Mar; 9(1):77-93. PMID: 22428362.
      View in: PubMed
    35. Cirka HA, Koehler SA, Farr WW, Billiar KL. Eccentric rheometry for viscoelastic characterization of small, soft, anisotropic, and irregularly shaped biopolymer gels and tissue biopsies. Ann Biomed Eng. 2012 Aug; 40(8):1654-65. PMID: 22361829.
      View in: PubMed
    36. Kural MH, Cai M, Tang D, Gwyther T, Zheng J, Billiar KL. Planar biaxial characterization of diseased human coronary and carotid arteries for computational modeling. J Biomech. 2012 Mar 15; 45(5):790-8. PMID: 22236530.
      View in: PubMed
    37. Liu H, Canton G, Yuan C, Yang C, Billiar K, Teng Z, Hoffman AH, Tang D. Using in vivo Cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictions. J Biomech Eng. 2012 Jan; 134(1):011008. PMID: 22482663.
      View in: PubMed
    38. Gwyther TA, Hu JZ, Billiar KL, Rolle MW. Directed cellular self-assembly to fabricate cell-derived tissue rings for biomechanical analysis and tissue engineering. J Vis Exp. 2011 Nov 25; (57):e3366. PMID: 22143346.
      View in: PubMed
    39. Throm Quinlan AM, Sierad LN, Capulli AK, Firstenberg LE, Billiar KL. Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro. PLoS One. 2011; 6(8):e23272. PMID: 21858051.
      View in: PubMed
    40. Gwyther TA, Hu JZ, Christakis AG, Skorinko JK, Shaw SM, Billiar KL, Rolle MW. Engineered vascular tissue fabricated from aggregated smooth muscle cells. Cells Tissues Organs. 2011; 194(1):13-24. PMID: 21252472.
      View in: PubMed
    41. Silva JA, McCormick JJ, Reed MA, Morse AS, Heffernan MJ, Lavado RD, Billiar K, Wixted JJ. Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study. Injury. 2010 Nov; 41 Suppl 2:S85-9. PMID: 21144935.
      View in: PubMed
    42. McCormick JJ, Li X, Weiss DR, Billiar KL, Wixted JJ. Biomechanical investigation of a novel ratcheting arthrodesis nail. J Orthop Surg Res. 2010; 5:74. PMID: 20942976.
      View in: PubMed
    43. Yao L, Billiar KL, Windebank AJ, Pandit A. Multichanneled collagen conduits for peripheral nerve regeneration: design, fabrication, and characterization. Tissue Eng Part C Methods. 2010 Dec; 16(6):1585-96. PMID: 20528663.
      View in: PubMed
    44. Broderick G, Lalikos J, Chowaniec M, Collins M, Wilson E, Babbitt R, O'Brien J, Billiar K, Dunn RM. Femur flap for tibial reconstruction: percent circumference required to convey a mechanical advantage over the fibula. J Reconstr Microsurg. 2010 Sep; 26(7):481-6. PMID: 20593345.
      View in: PubMed
    45. Peck L, Billiar K, Ray M. Dynamic failure properties of the porcine medial collateral ligament-bone complex for predicting injury in automotive collisions. Open Biomed Eng J. 2010; 4:77-84. PMID: 20461229.
      View in: PubMed
    46. Balestrini JL, Skorinko JK, Hera A, Gaudette GR, Billiar KL. Applying controlled non-uniform deformation for in vitro studies of cell mechanobiology. Biomech Model Mechanobiol. 2010 Jun; 9(3):329-44. PMID: 20169395.
      View in: PubMed
    47. Throm AM, Liu WC, Lock CH, Billiar KL. Development of a cell-derived matrix: effects of epidermal growth factor in chemically defined culture. J Biomed Mater Res A. 2010 Feb; 92(2):533-41. PMID: 19235212.
      View in: PubMed
    48. John J, Quinlan AT, Silvestri C, Billiar K. Boundary stiffness regulates fibroblast behavior in collagen gels. Ann Biomed Eng. 2010 Mar; 38(3):658-73. PMID: 20012205.
      View in: PubMed
    49. Yang C, Bach RG, Zheng J, Naqa IE, Woodard PK, Teng Z, Billiar K, Tang D. In vivo IVUS-based 3-D fluid-structure interaction models with cyclic bending and anisotropic vessel properties for human atherosclerotic coronary plaque mechanical analysis. IEEE Trans Biomed Eng. 2009 Oct; 56(10):2420-8. PMID: 19567341.
      View in: PubMed
    50. Tang D, Yang C, Kobayashi S, Zheng J, Woodard PK, Teng Z, Billiar K, Bach R, Ku DN. 3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis. J Biomech Eng. 2009 Jun; 131(6):061010. PMID: 19449964.
      View in: PubMed
    51. Balestrini JL, Billiar KL. Magnitude and duration of stretch modulate fibroblast remodeling. J Biomech Eng. 2009 May; 131(5):051005. PMID: 19388775.
      View in: PubMed
    52. Pai S, Dunn RM, Babbitt R, Strom HM, Lalikos JF, Pins GD, Billiar KL. Characterization of forces on the sternal midline following median sternotomy in a porcine model. J Biomech Eng. 2008 Oct; 130(5):051004. PMID: 19045511.
      View in: PubMed
    53. Marturano JE, Cleveland BC, Byrne MA, O'Connell SL, Wixted JJ, Billiar KL. An improved murine femur fracture device for bone healing studies. J Biomech. 2008; 41(6):1222-8. PMID: 18384794.
      View in: PubMed
    54. Coburn JC, Brody S, Billiar KL, Pandit A. Biaxial mechanical evaluation of cholecyst-derived extracellular matrix: a weakly anisotropic potential tissue engineered biomaterial. J Biomed Mater Res A. 2007 Apr; 81(1):250-6. PMID: 17269134.
      View in: PubMed
    55. Grouf JL, Throm AM, Balestrini JL, Bush KA, Billiar KL. Differential effects of EGF and TGF-beta1 on fibroblast activity in fibrin-based tissue equivalents. Tissue Eng. 2007 Apr; 13(4):799-807. PMID: 17346099.
      View in: PubMed
    56. Pai S, Gunja NJ, Dupak EL, McMahon NL, Coburn JC, Lalikos JF, Dunn RM, Francalancia N, Pins GD, Billiar KL. A mechanical study of rigid plate configurations for sternal fixation. Ann Biomed Eng. 2007 May; 35(5):808-16. PMID: 17377844.
      View in: PubMed
    57. Ahlfors JE, Billiar KL. Biomechanical and biochemical characteristics of a human fibroblast-produced and remodeled matrix. Biomaterials. 2007 Apr; 28(13):2183-91. PMID: 17280714.
      View in: PubMed
    58. Balestrini JL, Billiar KL. Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin. J Biomech. 2006; 39(16):2983-90. PMID: 16386746.
      View in: PubMed
    59. Pai S, Gunja NJ, Dupak EL, McMahon NL, Roth TP, Lalikos JF, Dunn RM, Francalancia N, Pins GD, Billiar KL. In vitro comparison of wire and plate fixation for midline sternotomies. Ann Thorac Surg. 2005 Sep; 80(3):962-8. PMID: 16122464.
      View in: PubMed
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