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Brian P O'Sullivan MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPediatrics
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPediatrics
    DivisionPediatric Pulmonology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research


    Collapse Biography 
    Collapse education and training
    Dartmouth College, Hanover, NH, United StatesABBiology
    Dartmouth College, Hanover, NH, United StatesMDMedicine

    Collapse Overview 
    Collapse overview

    Research Interests

    1. Cystic fibrosis and platelet function (in conjunctionwith Dr. Alan Michelson)

    2. Cystic fibrosis and fatty acid metabolism (in conjunction with Steven Freedman from BI Deaconess)

    3. Cystic fibrosis and newborn screening

    Funding Sources

    1. Cystic Fibrosis Therapuetics Inc: The effects of infant formula supplemented with DHA on Cystic Fibrosis.

    2. Worcester Foundation for Biomedical Science: Platelet function in carriers of the CF mutation

    3. CF Foundation: Early Pseudomonas aeruginosa infection control (EPIC)




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wilschanski M, Yaakov Y, Omari I, Zaman M, Martin CR, Cohen-Cymberknoh M, Shoseyov D, Kerem E, Dasilva D, Sheth S, Uluer A, O'Sullivan BP, Freedman S. Comparison of Nasal Potential Difference and Intestinal Current Measurements as Surrogate Markers for CFTR Function. J Pediatr Gastroenterol Nutr. 2016 Nov; 63(5):e92-e97. PMID: 27496797.
      View in: PubMed
    2. O'Sullivan BP. Importance of Off-Label Options for Treating Serious Lung Diseases. Ann Am Thorac Soc. 2016 Nov; 13(11):1879-1880. PMID: 27831808.
      View in: PubMed
    3. Orenstein DM, O'Sullivan BP, Quinton PM. Cystic Fibrosis: Breakthrough Drugs at Break-the-Bank Prices. Glob Adv Health Med. 2015 Nov; 4(6):8-57. PMID: 26659555.
      View in: PubMed
    4. Geake JB, Reid DW, Currie BJ, Bell SC. An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis. BMC Pulm Med. 2015; 15:116. PMID: 26453341.
      View in: PubMed
    5. Atun R, Jaffray DA, Barton MB, Bray F, Baumann M, Vikram B, Hanna TP, Knaul FM, Lievens Y, Lui TY, Milosevic M, O'Sullivan B, Rodin DL, Rosenblatt E, Van Dyk J, Yap ML, Zubizarreta E, Gospodarowicz M. Expanding global access to radiotherapy. Lancet Oncol. 2015 Sep; 16(10):1153-86. PMID: 26419354.
      View in: PubMed
    6. Huang SH, Xu W, Waldron J, Siu L, Shen X, Tong L, Ringash J, Bayley A, Kim J, Hope A, Cho J, Giuliani M, Hansen A, Irish J, Gilbert R, Gullane P, Perez-Ordonez B, Weinreb I, Liu FF, O'Sullivan B. Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. J Clin Oncol. 2015 Mar 10; 33(8):836-45. PMID: 25667292.
      View in: PubMed
    7. Huang SH, Waldron JN, Milosevic M, Shen X, Ringash J, Su J, Tong L, Perez-Ordonez B, Weinreb I, Bayley AJ, Kim J, Hope A, Cho BC, Giuliani M, Razak A, Goldstein D, Shi W, Liu FF, Xu W, O'Sullivan B. Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status. Cancer. 2015 Feb 15; 121(4):545-55. PMID: 25336438.
      View in: PubMed
    8. O'Sullivan B, Couch M, Roche JP, Walvick R, Zheng S, Baker D, Johnson M, Botfield M, Albert MS. Assessment of repeatability of hyperpolarized gas MR ventilation functional imaging in cystic fibrosis. Acad Radiol. 2014 Dec; 21(12):1524-9. PMID: 25172411.
      View in: PubMed
    9. O'Donnell PW, Griffin AM, Eward WC, Sternheim A, Catton CN, Chung PW, O'Sullivan B, Ferguson PC, Wunder JS. The effect of the setting of a positive surgical margin in soft tissue sarcoma. Cancer. 2014 Sep 15; 120(18):2866-75. PMID: 24894656.
      View in: PubMed
    10. O'Sullivan BP. Targeting nonsense-mediated cystic fibrosis: is it premature to stop now? Lancet Respir Med. 2014 Jul; 2(7):509-11. PMID: 24836206.
      View in: PubMed
    11. O'Sullivan BP, Orenstein DM, Milla CE. Pricing for orphan drugs: will the market bear what society cannot? JAMA. 2013 Oct 2; 310(13):1343-4. PMID: 24084916.
      View in: PubMed
    12. O'Sullivan BP, Sassetti CM. Infection control in cystic fibrosis: share and share alike. Lancet. 2013 May 4; 381(9877):1517-9. PMID: 23541536.
      View in: PubMed
    13. Coates A, Schaefer O, Uy K, O'Sullivan BP. Empyema in a woman with cystic fibrosis: a cautionary tale. Case Rep Pulmonol. 2013; 2013:159508. PMID: 23533902.
      View in: PubMed
    14. O'Sullivan BP, Baker D, Leung KG, Reed G, Baker SS, Borowitz D. Evolution of pancreatic function during the first year in infants with cystic fibrosis. J Pediatr. 2013 Apr; 162(4):808-812.e1. PMID: 23245194.
      View in: PubMed
    15. O'Sullivan BP, Zwerdling RG, Kremer T. A patient with asthma seeks medical advice. N Engl J Med. 2012 May 3; 366(18):1740-1; author reply 1742. PMID: 22551143.
      View in: PubMed
    16. Hui AB, Bruce JP, Alajez NM, Shi W, Yue S, Perez-Ordonez B, Xu W, O'Sullivan B, Waldron J, Cummings B, Gullane P, Siu L, Liu FF. Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clin Cancer Res. 2011 Dec 15; 17(24):7539-50. PMID: 22031094.
      View in: PubMed
    17. Sun Y, O'Sullivan BP, Roche JP, Walvick R, Reno A, Baker D, Mansour JK, Albert MS. Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients. J Magn Reson Imaging. 2011 Nov; 34(5):1206-11. PMID: 21932361.
      View in: PubMed
    18. O'Sullivan BP, Torres B, Conidi G, Smole S, Gauthier C, Stauffer KE, Glass MB, Gee JE, Blaney D, Smith TL. Burkholderia pseudomallei infection in a child with cystic fibrosis: acquisition in the Western Hemisphere. Chest. 2011 Jul; 140(1):239-42. PMID: 21729895.
      View in: PubMed
    19. O'Sullivan BP. Pulmonary complications of systemic vasculitides. Paediatr Respir Rev. 2012 Mar; 13(1):37-43. PMID: 22208792.
      View in: PubMed
    20. Hale JE, Parad RB, Dorkin HL, Gerstle R, Lapey A, O'Sullivan BP, Spencer T, Yee W, Comeau AM. Cystic fibrosis newborn screening: using experience to optimize the screening algorithm. J Inherit Metab Dis. 2010 Oct; 33(Suppl 2):S255-61. PMID: 20521170.
      View in: PubMed
    21. O'Sullivan BP, Yasothan U, Kirkpatrick P. Inhaled aztreonam. Nat Rev Drug Discov. 2010 May; 9(5):357-8. PMID: 20431562.
      View in: PubMed
    22. O'Sullivan BP, Flume P. The clinical approach to lung disease in patients with cystic fibrosis. Semin Respir Crit Care Med. 2009 Oct; 30(5):505-13. PMID: 19760538.
      View in: PubMed
    23. Hui AB, Yue S, Shi W, Alajez NM, Ito E, Green SR, Frame S, O'Sullivan B, Liu FF. Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma. Clin Cancer Res. 2009 Jun 1; 15(11):3716-24. PMID: 19470731.
      View in: PubMed
    24. O'Sullivan BP, Freedman SD. Cystic fibrosis. Lancet. 2009 May 30; 373(9678):1891-904. PMID: 19403164.
      View in: PubMed
    25. Carlson D, McKeen E, Mitchell M, Torres B, Parad R, Comeau AM, O'Sullivan BP. Oropharyngeal flora in healthy infants: observations and implications for cystic fibrosis care. Pediatr Pulmonol. 2009 May; 44(5):497-502. PMID: 19360845.
      View in: PubMed
    26. Flume PA, Robinson KA, O'Sullivan BP, Finder JD, Vender RL, Willey-Courand DB, White TB, Marshall BC. Cystic fibrosis pulmonary guidelines: airway clearance therapies. Respir Care. 2009 Apr; 54(4):522-37. PMID: 19327189.
      View in: PubMed
    27. O'Sullivan BP, Zwerdling RG. By the sweat of our brows: how salty should a person be? J Pediatr. 2008 Dec; 153(6):735-6. PMID: 19014812.
      View in: PubMed
    28. Walker M, O'Sullivan B, Perakath B, Taniere P, Cruger D, Morton D. Selecting patients with young-onset colorectal cancer for mismatch repair gene analysis. Br J Surg. 2007 Dec; 94(12):1567-71. PMID: 17665423.
      View in: PubMed
    29. Flume PA, O'Sullivan BP, Robinson KA, Goss CH, Mogayzel PJ, Willey-Courand DB, Bujan J, Finder J, Lester M, Quittell L, Rosenblatt R, Vender RL, Hazle L, Sabadosa K, Marshall B. Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health. Am J Respir Crit Care Med. 2007 Nov 15; 176(10):957-69. PMID: 17761616.
      View in: PubMed
    30. Tarnow I, Michelson AD, Frelinger AL, Linden MD, Li Y, Fox ML, Barnard MR, O'Sullivan BP. Cystic fibrosis heterozygotes do not have increased platelet activation. Thromb Res. 2007; 121(2):159-62. PMID: 17532368.
      View in: PubMed
    31. Comeau AM, Accurso FJ, White TB, Campbell PW, Hoffman G, Parad RB, Wilfond BS, Rosenfeld M, Sontag MK, Massie J, Farrell PM, O'Sullivan BP. Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report. Pediatrics. 2007 Feb; 119(2):e495-518. PMID: 17272609.
      View in: PubMed
    32. Batal I, Ericsoussi MB, Cluette-Brown JE, O'Sullivan BP, Freedman SD, Savaille JE, Laposata M. Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis. Clin Chem. 2007 Jan; 53(1):78-84. PMID: 17130178.
      View in: PubMed
    33. O'Sullivan BP, Zwerdling RG, Dorkin HL, Comeau AM, Parad R. Early pulmonary manifestation of cystic fibrosis in children with the DeltaF508/R117H-7T genotype. Pediatrics. 2006 Sep; 118(3):1260-5. PMID: 16951024.
      View in: PubMed
    34. Schreiber D, Bell RS, Wunder JS, O'Sullivan B, Turcotte R, Masri BA, Davis AM. Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma. Qual Life Res. 2006 Nov; 15(9):1439-46. PMID: 16732468.
      View in: PubMed
    35. O'Sullivan BP, Michelson AD. The inflammatory role of platelets in cystic fibrosis. Am J Respir Crit Care Med. 2006 Mar 1; 173(5):483-90. PMID: 16339920.
      View in: PubMed
    36. Comeau AM, Parad R, Gerstle R, O'Sullivan BP, Dorkin HL, Dovey M, Haver K, Martin T, Eaton RB. Challenges in implementing a successful newborn cystic fibrosis screening program. J Pediatr. 2005 Sep; 147(3 Suppl):S89-93. PMID: 16202791.
      View in: PubMed
    37. Comeau AM, Parad R, Gerstle R, O'Sullivan BP, Dorkin HL, Dovey M, Haver K, Martin T, Eaton RB. Communications systems and their models: Massachusetts parent compliance with recommended specialty care after positive cystic fibrosis newborn screening result. J Pediatr. 2005 Sep; 147(3 Suppl):S98-100. PMID: 16202793.
      View in: PubMed
    38. Parad RB, Comeau AM, Dorkin HL, Dovey M, Gerstle R, Martin T, O'Sullivan BP. Sweat testing infants detected by cystic fibrosis newborn screening. J Pediatr. 2005 Sep; 147(3 Suppl):S69-72. PMID: 16202787.
      View in: PubMed
    39. Ringash J, Warde P, Lockwood G, O'Sullivan B, Waldron J, Cummings B. Postradiotherapy quality of life for head-and-neck cancer patients is independent of xerostomia. Int J Radiat Oncol Biol Phys. 2005 Apr 1; 61(5):1403-7. PMID: 15817343.
      View in: PubMed
    40. O'Sullivan BP, Linden MD, Frelinger AL, Barnard MR, Spencer-Manzon M, Morris JE, Salem RO, Laposata M, Michelson AD. Platelet activation in cystic fibrosis. Blood. 2005 Jun 15; 105(12):4635-41. PMID: 15705796.
      View in: PubMed
    41. Ghert MA, Abudu A, Driver N, Davis AM, Griffin AM, Pearce D, White L, O'Sullivan B, Catton CN, Bell RS, Wunder JS. The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremity. Ann Surg Oncol. 2005 Jan; 12(1):10-7. PMID: 15827772.
      View in: PubMed
    42. Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, Shea JC, Kelly C, O'Sullivan BP, Freedman SD. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol. 2004 Sep; 11(5):819-24. PMID: 15358638.
      View in: PubMed
    43. Comeau AM, Parad RB, Dorkin HL, Dovey M, Gerstle R, Haver K, Lapey A, O'Sullivan BP, Waltz DA, Zwerdling RG, Eaton RB. Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: a cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections. Pediatrics. 2004 Jun; 113(6):1573-81. PMID: 15173476.
      View in: PubMed
    44. O'Sullivan BP, Finger L, Zwerdling RG. Use of nasopharyngoscopy in the evaluation of children with noisy breathing. Chest. 2004 Apr; 125(4):1265-9. PMID: 15078733.
      View in: PubMed
    45. Parker EM, O'Sullivan BP, Shea JC, Regan MM, Freedman SD. Survey of breast-feeding practices and outcomes in the cystic fibrosis population. Pediatr Pulmonol. 2004 Apr; 37(4):362-7. PMID: 15022134.
      View in: PubMed
    46. Freedman SD, Blanco PG, Zaman MM, Shea JC, Ollero M, Hopper IK, Weed DA, Gelrud A, Regan MM, Laposata M, Alvarez JG, O'Sullivan BP. Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med. 2004 Feb 5; 350(6):560-9. PMID: 14762183.
      View in: PubMed
    47. Zwerdling RG, O'Sullivan BP. Treatment of bronchiolitis. N Engl J Med. 2003 Oct 2; 349(14):1384-5; author reply 1384-5. PMID: 14523149.
      View in: PubMed
    48. Quaine J, Eyeson-Annan M, Baker D, O'Sullivan B, Williamson M, Jorm L. Report on the development of the New South Wales Child Health Survey 2001. N S W Public Health Bull. 2003 Feb; 14 Suppl 1:1-71. PMID: 12555105.
      View in: PubMed
    49. O'Sullivan BP, Erickson LA, Niles JL. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 30-2002. An eight-year-old girl with fever, hemoptysis, and pulmonary consolidations. N Engl J Med. 2002 Sep 26; 347(13):1009-17. PMID: 12324558.
      View in: PubMed
    50. O'Sullivan BP. Risks and complications of nonbronchoscopic bronchoalveolar lavage in a pediatric intensive care unit. Pediatr Pulmonol. 2002 Jul; 34(1):87-8; author reply 88. PMID: 12112804.
      View in: PubMed
    51. Paisley S, Warde PR, O'Sullivan B, Waldron J, Gullane PJ, Payne D, Liu FF, Bayley A, Ringash J, Cummings BJ. Results of radiotherapy for primary subglottic squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2002 Apr 1; 52(5):1245-50. PMID: 11955735.
      View in: PubMed
    52. Joseph PM, O'Sullivan BP, Lapey A, Dorkin H, Oren J, Balfour R, Perricone MA, Rosenberg M, Wadsworth SC, Smith AE, St George JA, Meeker DP. Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications. Hum Gene Ther. 2001 Jul 20; 12(11):1369-82. PMID: 11485629.
      View in: PubMed
    53. Perricone MA, Morris JE, Pavelka K, Plog MS, O'Sullivan BP, Joseph PM, Dorkin H, Lapey A, Balfour R, Meeker DP, Smith AE, Wadsworth SC, St George JA. Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium. Hum Gene Ther. 2001 Jul 20; 12(11):1383-94. PMID: 11485630.
      View in: PubMed
    54. Feingold B, O'Sullivan B, del Nido P, Pollack P. Situs inversus totalis and corrected transposition of the great arteries [I,D,D] in association with a previously unreported vascular ring. Pediatr Cardiol. 2001 Jul-Aug; 22(4):338-42. PMID: 11455405.
      View in: PubMed
    55. O'Sullivan BP, Frassica JJ, Rayder SM. Tracheal bronchus: a cause of prolonged atelectasis in intubated children. Chest. 1998 Feb; 113(2):537-40. PMID: 9498980.
      View in: PubMed
    56. Bouwes Bavinck JN, Hardie DR, Green A, Cutmore S, MacNaught A, O'Sullivan B, Siskind V, Van Der Woude FJ, Hardie IR. The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation. 1996 Mar 15; 61(5):715-21. PMID: 8607173.
      View in: PubMed
    57. VanderMeer TJ, Menconi MJ, O'Sullivan BP, Larkin VA, Wang H, Sofia M, Fink MP. Acute lung injury in endotoxemic pigs: role of leukotriene B4. J Appl Physiol (1985). 1995 Mar; 78(3):1121-31. PMID: 7775306.
      View in: PubMed
    58. Nimkin K, Kleinman PK, Zwerdling RG, Spevak MR, O'Sullivan BP. Localized pneumothorax with lobar collapse and diffuse obstructive airway disease. Pediatr Radiol. 1995; 25(6):449-51. PMID: 7491198.
      View in: PubMed
    59. Wollert PS, Menconi MJ, Wang H, O'Sullivan BP, Larkin V, Allen RC, Fink MP. Prior exposure to endotoxin exacerbates lipopolysaccharide-induced hypoxemia and alveolitis in anesthetized swine. Shock. 1994 Nov; 2(5):362-9. PMID: 7743363.
      View in: PubMed
    60. O'Sullivan BP, Spaulding R. The use of aerosolized pentamidine for prophylaxis of Pneumocystis carinii pneumonia in children with leukemia. Pediatr Pulmonol. 1994 Oct; 18(4):228-31. PMID: 7838621.
      View in: PubMed
    61. Vandermeer TJ, Menconi MJ, O'Sullivan BP, Larkin VA, Wang H, Kradin RL, Fink MP. Bactericidal/permeability-increasing protein ameliorates acute lung injury in porcine endotoxemia. J Appl Physiol (1985). 1994 May; 76(5):2006-14. PMID: 8063663.
      View in: PubMed
    62. Fink MP, O'Sullivan BP, Menconi MJ, Wollert PS, Wang H, Youssef ME, Fleisch JH. A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model. Crit Care Med. 1993 Dec; 21(12):1825-37. PMID: 8252886.
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    63. O'Sullivan BP, Nimkin K, Gang DL. A fifteen-year-old boy with eosinophilia and pulmonary infiltrates. J Pediatr. 1993 Oct; 123(4):660-6. PMID: 8410525.
      View in: PubMed
    64. Wollert PS, Menconi MJ, O'Sullivan BP, Wang H, Larkin V, Fink MP. LY255283, a novel leukotriene B4 receptor antagonist, limits activation of neutrophils and prevents acute lung injury induced by endotoxin in pigs. Surgery. 1993 Aug; 114(2):191-8. PMID: 8393594.
      View in: PubMed
    65. Fink MP, O'Sullivan BP, Menconi MJ, Wollert SP, Wang H, Youssef ME, Bellelsle JM. Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J Trauma. 1993 Apr; 34(4):571-7; discussion 577-8. PMID: 7683731.
      View in: PubMed
    66. O'Sullivan BP, Mong S, Votta B, Schidlow DV. Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung. Prostaglandins Leukot Essent Fatty Acids. 1992 Jul; 46(3):203-10. PMID: 1324504.
      View in: PubMed
    67. Alpert BE, O'Sullivan BP, Panitch HB. Nonbronchoscopic approach to bronchoalveolar lavage in children with artificial airways. Pediatr Pulmonol. 1992 May; 13(1):38-41. PMID: 1589310.
      View in: PubMed
    68. O'Sullivan BP, Mong S. Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. Mol Pharmacol. 1989 Jun; 35(6):795-802. PMID: 2543913.
      View in: PubMed
    69. O'Sullivan BP. Carbon monoxide poisoning in an infant exposed to a kerosene heater. J Pediatr. 1983 Aug; 103(2):249-51. PMID: 6875719.
      View in: PubMed
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