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Silvia Corvera MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street, Two Biotech, Suite 107
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Colegio Madrid, Madrid, DF, MexicoBSScience
    Universidad Nacional Autonoma de Mexico, Mexico City, , MexicoMSBiochemistry
    Universidad Nacional Autonoma de Mexico, Mexico City, , MexicoMD

    Collapse Overview 
    Collapse overview

    Academic Background


    Silvia Corvera is Professor of Molecular Medicine, co-director of the MD/PhD program, and director of the Clinical Translational Research Pathway. She holds the Endowed Chair in Diabetes Research.


    She received her M.D. and MSc in Molecular Biology at the Universidad Nacional Autonoma de Mexico, and was awarded a Fogarty International Fellowship to conduct postdoctoral studies in the US. She was on the Faculty at the Department of Pathology at the University of Pennsylvania (1987-1990) before moving to the newly formed Program in Molecular Medicine at the University of Massachusetts Medical School.


    Current Research


    Metabolic diseases, such as type-2 diabetes, non-alcoholic fatty liver disease (NASH), and hypertension are an emerging worldwide epidemic associated with substantial human suffering and a large economic burden. We are interested in understanding the cellular and molecular mechanisms that underlie metabolic diseases, and enable therapeutic strategies to be developed.


    We are specifically interested in human adipose tissue. Adipose tissue has amazing properties: each adipocyte can expand its size very rapidly, and is able to increase lipid storage 4-5 fold. In response to fasting, it rapidly releases this lipid to provide energy to the entire body. However, there seems to be a maximal capacity to expand, and when this capacity is reached adipocyte function fails. How the adipocyte can change its volume so dynamically is a very interesting cell biology question, and a very relevant one in understanding metabolic disease mechanisms. In fact, at similar weight, individuals whose adipose tissue is made up of many small adipocytes are at a lower risk of metabolic disease compared to individuals whose tissue contains fewer large adipocytes. Thus, one of our main interests is to understand the mechanisms that control the number and size of adipocytes.


    Another amazing property of adipose tissue is its diversity of functions. We usually think of adipose tissue as a site for fat storage. However, a form of adipose tissue, called “brite” or “beige” in humans, is constantly burning fat to generate heat. “Brite/beige” adipose tissue is localized around the neck, close to major blood vessels, where the heat generated can serve to maintain core temperature. Humans who have more of this heat-generating adipose tissue tend to be lean and metabolically healthy, but what mechanisms underlie this correlation is not known. We have developed an approach to generate human “brite/beige” adipocytes in-vitro, and found that these cells can improve glucose metabolism when implanted into immune-compromised mice. A major goal now is to understand the mechanism for this effect, by discovering what factors stimulate the proliferation and differentiation of human brite/beige adipocytes, and whether these cells improve glucose metabolism through consumption of energy, through effects on other tissues, or both.


    Another great unknown in the field of adipose tissue are the genetic factors that define its body pattern. Some individuals develop more adipose tissue under the skin in upper or lower extremities, while others have larger amounts in the abdominal region. These latter individuals are at a much higher risk of metabolic disease, even with little weight gain. We have developed an approach to generate adipose tissue “organoids”, starting from minute fragments of human adipose tissue that can be obtained through needle suction. These fragments can be induced to develop microvasculature and new adipocyte progenitors, which differentiate into functional adipocytes within a multicellular context. By studying the properties of adipose organoids generated from different body sites, and from individuals with differing body shapes, we hope to gain insight on the major determinants of human adipose tissue patterning.



    Strong collaborations with clinical partners from the Departments of Surgery and OBGyN have allowed us to use human adipose tissue for our studies and determine how these are associated with diseases such as type 2 diabetes and gestational diabetes.



    Collapse Rotation Projects


    Rotation Projects



    Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work.



    Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study.



    Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In this project you will knockout these genes, and investigate whether this changes the function of adipose tissue when we implant it into immune compromised mice.



     



     



     



     



     



     



    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Corvera for additional details.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Maurizi G, Poloni A, Mattiucci D, Santi S, Maurizi A, Izzi V, Giuliani A, Mancini S, Zingaretti MC, Perugini J, Severi I, Falconi M, Vivarelli M, Rippo MR, Corvera S, Giordano A, Leoni P, Cinti S. Cover Image, Volume 232, Number 10, October 2017. J Cell Physiol. 2017 Oct; 232(10):i. PMID: 28644916.
      View in: PubMed
    2. Maurizi G, Poloni A, Mattiucci D, Santi S, Maurizi A, Izzi V, Giuliani A, Mancini S, Zingaretti MC, Perugini J, Severi I, Falconi M, Vivarelli M, Rippo MR, Corvera S, Giordano A, Leoni P, Cinti S. Human white adipocytes convert into "rainbow" adipocytes in vitro. J Cell Physiol. 2016 Dec 17. PMID: 27987321.
      View in: PubMed
    3. Ly S, Navaroli DM, Didiot MC, Cardia J, Pandarinathan L, Alterman JF, Fogarty K, Standley C, Lifshitz LM, Bellve KD, Prot M, Echeverria D, Corvera S, Khvorova A. Visualization of self-delivering hydrophobically modified siRNA cellular internalization. Nucleic Acids Res. 2017 Jan 09; 45(1):15-25. PMID: 27899655.
      View in: PubMed
    4. Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016 Mar; 22(3):312-8. PMID: 26808348.
      View in: PubMed
    5. Chappell AG, Lujan-Hernandez J, Perry DJ, Corvera S, Lalikos JF. Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis. Plast Reconstr Surg. 2015 Aug; 136(2):277e. PMID: 25946608.
      View in: PubMed
    6. Rojas-Rodriguez R, Lifshitz LM, Bellve KD, Min SY, Pires J, Leung K, Boeras C, Sert A, Draper JT, Corvera S, Moore Simas TA. Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia. 2015 Sep; 58(9):2106-14. PMID: 26067361.
      View in: PubMed
    7. Moore Simas TA, Corvera S, Lee MM, Zhang N, Leung K, Olendzki B, Barton B, Rosal MC. Understanding multifactorial influences on the continuum of maternal weight trajectories in pregnancy and early postpartum: study protocol, and participant baseline characteristics. BMC Pregnancy Childbirth. 2015 Mar 28; 15:71. PMID: 25885002.
      View in: PubMed
    8. Rohatgi RA, Janusis J, Leonard D, Bellvé KD, Fogarty KE, Baehrecke EH, Corvera S, Shaw LM. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015 Oct 16; 34(42):5352-62. PMID: 25639875.
      View in: PubMed
    9. Stockler S, Corvera S, Lambright D, Fogarty K, Nosova E, Leonard D, Steinfeld R, Ackerley C, Shyr C, Au N, Selby K, van Allen M, Vallance H, Wevers R, Watkins D, Rosenblatt D, Ross CJ, Conibear E, Wasserman W, van Karnebeek C. Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking. Orphanet J Rare Dis. 2014 Sep 20; 9:141. PMID: 25233840.
      View in: PubMed
    10. Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S. Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4. J Biol Chem. 2014 Jun 27; 289(26):18327-38. PMID: 24778188.
      View in: PubMed
    11. Rojas-Rodriguez R, Gealekman O, Kruse ME, Rosenthal B, Rao K, Min S, Bellve KD, Lifshitz LM, Corvera S. Adipose tissue angiogenesis assay. Methods Enzymol. 2014; 537:75-91. PMID: 24480342.
      View in: PubMed
    12. Corvera S, Gealekman O. Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta. 2014 Mar; 1842(3):463-72. PMID: 23770388.
      View in: PubMed
    13. Gealekman O, Guseva N, Gurav K, Gusev A, Hartigan C, Thompson M, Malkani S, Corvera S. Effect of rosiglitazone on capillary density and angiogenesis in adipose tissue of normoglycaemic humans in a randomised controlled trial. Diabetologia. 2012 Oct; 55(10):2794-9. PMID: 22847059.
      View in: PubMed
    14. Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2):81-7. PMID: 22327367.
      View in: PubMed
    15. Tran KV, Gealekman O, Frontini A, Zingaretti MC, Morroni M, Giordano A, Smorlesi A, Perugini J, De Matteis R, Sbarbati A, Corvera S, Cinti S. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012 Feb 8; 15(2):222-9. PMID: 22326223.
      View in: PubMed
    16. Navaroli DM, Bellvé KD, Standley C, Lifshitz LM, Cardia J, Lambright D, Leonard D, Fogarty KE, Corvera S. Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):E471-80. PMID: 22308388.
      View in: PubMed
    17. Young JL, Mora A, Cerny A, Czech MP, Woda B, Kurt-Jones EA, Finberg RW, Corvera S. CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone. PLoS One. 2012; 7(1):e29688. PMID: 22253759.
      View in: PubMed
    18. St Pierre CA, Leonard D, Corvera S, Kurt-Jones EA, Finberg RW. Antibodies to cell surface proteins redirect intracellular trafficking pathways. Exp Mol Pathol. 2011 Dec; 91(3):723-32. PMID: 21819978.
      View in: PubMed
    19. Corvera S, Czech MP. Tensions rise and blood flows over dysfunctional fat. Circulation. 2011 Jul 5; 124(1):13-6. PMID: 21730320.
      View in: PubMed
    20. Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, Tran KV, Straubhaar J, Nicoloro S, Czech MP, Thompson M, Perugini RA, Corvera S. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation. 2011 Jan 18; 123(2):186-94. PMID: 21200001.
      View in: PubMed
    21. Burkart A, Shi X, Chouinard M, Corvera S. Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response. J Biol Chem. 2011 Feb 11; 286(6):4081-9. PMID: 20876536.
      View in: PubMed
    22. Stuffers S, Malerød L, Schink KO, Corvera S, Stenmark H, Brech A. Time-resolved ultrastructural detection of phosphatidylinositol 3-phosphate. J Histochem Cytochem. 2010 Nov; 58(11):1025-32. PMID: 20713985.
      View in: PubMed
    23. Mishra A, Eathiraj S, Corvera S, Lambright DG. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10866-71. PMID: 20534488.
      View in: PubMed
    24. Walz HA, Shi X, Chouinard M, Bue CA, Navaroli DM, Hayakawa A, Zhou QL, Nadler J, Leonard DM, Corvera S. Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. J Biol Chem. 2010 May 07; 285(19):14101-8. PMID: 20189988.
      View in: PubMed
    25. Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010 Jun; 31(3):364-95. PMID: 20156986.
      View in: PubMed
    26. Leonard D, Hayakawa A, Lawe D, Lambright D, Bellve KD, Standley C, Lifshitz LM, Fogarty KE, Corvera S. Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci. 2008 Oct 15; 121(Pt 20):3445-58. PMID: 18827013.
      View in: PubMed
    27. Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S. Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem. 2008 Nov 7; 283(45):30658-67. PMID: 18779333.
      View in: PubMed
    28. Gealekman O, Burkart A, Chouinard M, Nicoloro SM, Straubhaar J, Corvera S. Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1056-64. PMID: 18728224.
      View in: PubMed
    29. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 3; 105(22):7833-8. PMID: 18509062.
      View in: PubMed
    30. Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP. Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol. 2007 May; 27(9):3456-69. PMID: 17339344.
      View in: PubMed
    31. Hayakawa A, Hayes S, Leonard D, Lambright D, Corvera S. Evolutionarily conserved structural and functional roles of the FYVE domain. Biochem Soc Symp. 2007; (74):95-105. PMID: 17233583.
      View in: PubMed
    32. Corvera S, Burkart A, Kim JY, Christianson J, Wang Z, Scherer PE. Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada. Genes Dev. 2006 Aug 15; 20(16):2193-201. PMID: 16912272.
      View in: PubMed
    33. Hayakawa A, Leonard D, Murphy S, Hayes S, Soto M, Fogarty K, Standley C, Bellve K, Lambright D, Mello C, Corvera S. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):11928-33. PMID: 16873553.
      View in: PubMed
    34. Bellve KD, Leonard D, Standley C, Lifshitz LM, Tuft RA, Hayakawa A, Corvera S, Fogarty KE. Plasma membrane domains specialized for clathrin-mediated endocytosis in primary cells. J Biol Chem. 2006 Jun 9; 281(23):16139-46. PMID: 16537543.
      View in: PubMed
    35. Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, Straubhaar J, Czech MP, Corvera S. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest. 2004 Nov; 114(9):1281-9. PMID: 15520860.
      View in: PubMed
    36. Bose A, Robida S, Furcinitti PS, Chawla A, Fogarty K, Corvera S, Czech MP. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol. 2004 Jun; 24(12):5447-58. PMID: 15169906.
      View in: PubMed
    37. Blüher M, Wilson-Fritch L, Leszyk J, Laustsen PG, Corvera S, Kahn CR. Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem. 2004 Jul 23; 279(30):31902-9. PMID: 15131120.
      View in: PubMed
    38. Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12; 279(11):10593-605. PMID: 14676205.
      View in: PubMed
    39. Hayakawa A, Hayes SJ, Lawe DC, Sudharshan E, Tuft R, Fogarty K, Lambright D, Corvera S. Structural basis for endosomal targeting by FYVE domains. J Biol Chem. 2004 Feb 13; 279(7):5958-66. PMID: 14594806.
      View in: PubMed
    40. Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R. Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10382-7. PMID: 12930893.
      View in: PubMed
    41. Lawe DC, Sitouah N, Hayes S, Chawla A, Virbasius JV, Tuft R, Fogarty K, Lifshitz L, Lambright D, Corvera S. Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Mol Biol Cell. 2003 Jul; 14(7):2935-45. PMID: 12857876.
      View in: PubMed
    42. Burkart A, Samii B, Corvera S, Shpetner HS. Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem. 2003 May 16; 278(20):18360-7. PMID: 12611902.
      View in: PubMed
    43. Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol. 2003 Feb; 23(3):1085-94. PMID: 12529412.
      View in: PubMed
    44. Hayes S, Chawla A, Corvera S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol. 2002 Sep 30; 158(7):1239-49. PMID: 12356868.
      View in: PubMed
    45. Corvera S. Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs. Traffic. 2001 Dec; 2(12):859-66. PMID: 11737823.
      View in: PubMed
    46. Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG. Multivalent endosome targeting by homodimeric EEA1. Mol Cell. 2001 Nov; 8(5):947-58. PMID: 11741531.
      View in: PubMed
    47. Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S. Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem. 2002 Mar 8; 277(10):8611-7. PMID: 11602609.
      View in: PubMed
    48. Patki V, Buxton J, Chawla A, Lifshitz L, Fogarty K, Carrington W, Tuft R, Corvera S. Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol Biol Cell. 2001 Jan; 12(1):129-41. PMID: 11160828.
      View in: PubMed
    49. Corvera S, DiBonaventura C, Shpetner HS. Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol. J Biol Chem. 2000 Oct 6; 275(40):31414-21. PMID: 10903311.
      View in: PubMed
    50. Corvera S. Signal transduction: stuck with FYVE domains. Sci STKE. 2000 Jun 20; 2000(37):pe1. PMID: 11752593.
      View in: PubMed
    51. Lawe DC, Patki V, Heller-Harrison R, Lambright D, Corvera S. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J Biol Chem. 2000 Feb 4; 275(5):3699-705. PMID: 10652369.
      View in: PubMed
    52. Corvera S, D'Arrigo A, Stenmark H. Phosphoinositides in membrane traffic. Curr Opin Cell Biol. 1999 Aug; 11(4):460-5. PMID: 10449332.
      View in: PubMed
    53. Czech MP, Corvera S. Signaling mechanisms that regulate glucose transport. J Biol Chem. 1999 Jan 22; 274(4):1865-8. PMID: 9890935.
      View in: PubMed
    54. Corvera S, Czech MP. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol. 1998 Nov; 8(11):442-6. PMID: 9854311.
      View in: PubMed
    55. Patki V, Lawe DC, Corvera S, Virbasius JV, Chawla A. A functional PtdIns(3)P-binding motif. Nature. 1998 Jul 30; 394(6692):433-4. PMID: 9697765.
      View in: PubMed
    56. Patki V, Virbasius J, Lane WS, Toh BH, Shpetner HS, Corvera S. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7326-30. PMID: 9207090.
      View in: PubMed
    57. Hartley D, Corvera S. Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism. J Biol Chem. 1996 Sep 6; 271(36):21939-43. PMID: 8702998.
      View in: PubMed
    58. Shpetner H, Joly M, Hartley D, Corvera S. Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J Cell Biol. 1996 Feb; 132(4):595-605. PMID: 8647891.
      View in: PubMed
    59. Hartley D, Meisner H, Corvera S. Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl. J Biol Chem. 1995 Aug 4; 270(31):18260-3. PMID: 7629144.
      View in: PubMed
    60. Joly M, Kazlauskas A, Corvera S. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J Biol Chem. 1995 Jun 2; 270(22):13225-30. PMID: 7768921.
      View in: PubMed
    61. Corvera S, Chawla A, Chakrabarti R, Joly M, Buxton J, Czech MP. A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol. 1994 Sep; 126(6):1625. PMID: 8089191.
      View in: PubMed
    62. Corvera S, Chawla A, Chakrabarti R, Joly M, Buxton J, Czech MP. A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol. 1994 Aug; 126(4):979-89. PMID: 7519625.
      View in: PubMed
    63. Joly M, Kazlauskas A, Fay FS, Corvera S. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science. 1994 Feb 4; 263(5147):684-7. PMID: 8303278.
      View in: PubMed
    64. Czech MP, Chawla A, Woon CW, Buxton J, Armoni M, Tang W, Joly M, Corvera S. Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization. J Cell Biol. 1993 Oct; 123(1):127-35. PMID: 8408193.
      View in: PubMed
    65. Chakrabarti R, Joly M, Corvera S. Redistribution of clathrin-coated vesicle adaptor complexes during adipocytic differentiation of 3T3-L1 cells. J Cell Biol. 1993 Oct; 123(1):79-87. PMID: 8408208.
      View in: PubMed
    66. Kapeller R, Chakrabarti R, Cantley L, Fay F, Corvera S. Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton. Mol Cell Biol. 1993 Oct; 13(10):6052-63. PMID: 8413207.
      View in: PubMed
    67. Corvera S, Jaspers S, Pasceri M. Acute inhibition of insulin-stimulated glucose transport by the phosphatase inhibitor, okadaic acid. J Biol Chem. 1991 May 15; 266(14):9271-5. PMID: 1709166.
      View in: PubMed
    68. Corvera S. Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes. J Biol Chem. 1990 Feb 15; 265(5):2413-6. PMID: 2154445.
      View in: PubMed
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