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William H Gaasch MD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressLahey Clinic
41 Mall Road
Burlington MA 01805
Phone781-744-8535
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine


    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesBSChemistry
    University of Michigan Medical School, Ann Arbor, MI, United StatesMDMedicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gaasch WH, Meyer TE. Secondary mitral regurgitation (part 2): deliberations on mitral surgery and transcatheter repair. Heart. 2018 Apr; 104(8):639-643. PMID: 29437886.
      View in: PubMed
    2. Gaasch WH, Meyer TE. Secondary mitral regurgitation (part 1): volumetric quantification and analysis. Heart. 2018 Apr; 104(8):634-638. PMID: 28954829.
      View in: PubMed
    3. Gaasch WH. Deliberations on Diastolic Heart Failure. Am J Cardiol. 2016 Sep 29. PMID: 28029360.
      View in: PubMed
    4. Gaasch WH, Shah SP, Labib SB, Meyer TE. Impedance to retrograde and forward flow in chronic mitral regurgitation and the physiology of a double outlet ventricle. Heart. 2016 Sep 28. PMID: 27683406.
      View in: PubMed
    5. Gaasch WH. Right Heart Pressure Transients and Pulmonary Venous Pressure. Cardiology. 2016; 135(2):77-80. PMID: 27288042.
      View in: PubMed
    6. Gaasch WH, Aurigemma GP. CMR imaging of extracellular volume and myocardial strain in hypertensive heart disease. JACC Cardiovasc Imaging. 2015 Feb; 8(2):181-3. PMID: 25677890.
      View in: PubMed
    7. Draper TS, Silver JS, Gaasch WH. Adverse structural remodeling of the left ventricle and ventricular arrhythmias in patients with depressed ejection fraction. J Card Fail. 2015 Feb; 21(2):97-102. PMID: 25463741.
      View in: PubMed
    8. Zile MR, Gaasch WH, Patel K, Aban IB, Ahmed A. Adverse left ventricular remodeling in community-dwelling older adults predicts incident heart failure and mortality. JACC Heart Fail. 2014 Oct; 2(5):512-22. PMID: 25194295.
      View in: PubMed
    9. Shah SP, Kumar A, Draper TS, Gaasch WH. Hypertension in patients with severe aortic stenosis: emphasis on antihypertensive treatment and the risk of syncope. Curr Hypertens Rev. 2014; 10(3):149-54. PMID: 25567504.
      View in: PubMed
    10. Gaasch WH, D'Agostino RS. Transcatheter aortic valve implantation: The transfemoral versus the transapical approach. Ann Cardiothorac Surg. 2012 Jul; 1(2):200-5. PMID: 23977495.
      View in: PubMed
    11. Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011 Oct 18; 58(17):1733-40. PMID: 21996383.
      View in: PubMed
    12. Zile MR, Gaasch WH. Abnormal calcium homeostasis: one mechanism in diastolic heart failure. J Am Coll Cardiol. 2011 Jul 5; 58(2):155-7. PMID: 21718912.
      View in: PubMed
    13. Goldberg RJ, Spencer FA, Szklo-Coxe M, Tisminetzky M, Yarzebski J, Lessard D, Gore JM, Gaasch W. Symptom presentation in patients hospitalized with acute heart failure. Clin Cardiol. 2010 Jun; 33(6):E73-80. PMID: 20552612.
      View in: PubMed
    14. Doumas A, Draper TS, Schick EC, Gaasch WH. Prevalence and clinical characteristics of nondilated cardiomyopathy and the effect of atrial fibrillation. Am J Cardiol. 2010 Mar 15; 105(6):884-7. PMID: 20211338.
      View in: PubMed
    15. Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, Lopez-Sendon J, Teerlink JR, White M, McMurray JJ, Komajda M, McKelvie R, Ptaszynska A, Hetzel SJ, Massie BM, Carson PE. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010 Mar 30; 121(12):1393-405. PMID: 20231531.
      View in: PubMed
    16. Gaasch WH, Delorey DE, Kueffer FJ, Zile MR. Distribution of left ventricular ejection fraction in patients with ischemic and hypertensive heart disease and chronic heart failure. Am J Cardiol. 2009 Nov 15; 104(10):1413-5. PMID: 19892060.
      View in: PubMed
    17. Gaasch WH, Meyer TE. Left ventricular response to mitral regurgitation: implications for management. Circulation. 2008 Nov 25; 118(22):2298-303. PMID: 19029478.
      View in: PubMed
    18. Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008 Oct 7; 118(15):e523-661. PMID: 18820172.
      View in: PubMed
    19. Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008 Sep 23; 52(13):e1-142. PMID: 18848134.
      View in: PubMed
    20. Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM, Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC, Jacobs AK, Buller CE, Creager MA, Ettinger SM, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Page RL, Tarkington LG, Yancy CW. ACC/AHA 2008 guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Catheter Cardiovasc Interv. 2008 Sep 1; 72(3):E1-12. PMID: 18671249.
      View in: PubMed
    21. Nishimura RA, Carabello BA, Faxon DP, Freed MD, Lytle BW, O'Gara PT, O'Rourke RA, Shah PM, Bonow RO, Carabello BA, Chatterjee K, de Leon AC, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC, Jacobs AK, Buller CE, Creager MA, Ettinger SM, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Page RL, Tarkington LG, Yancy CW. ACC/AHA 2008 guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008 Aug 19; 118(8):887-96. PMID: 18663090.
      View in: PubMed
    22. Farr MJ, Lang CC, Lamanca JJ, Zile MR, Francis G, Tavazzi L, Gaasch WH, St John Sutton M, Itoh H, Mancini D. Cardiopulmonary exercise variables in diastolic versus systolic heart failure. Am J Cardiol. 2008 Jul 15; 102(2):203-6. PMID: 18602522.
      View in: PubMed
    23. Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol. 2008 Aug 15; 102(4):459-62. PMID: 18678306.
      View in: PubMed
    24. Gaasch WH, Little WC. Assessment of left ventricular diastolic function and recognition of diastolic heart failure. Circulation. 2007 Aug 7; 116(6):591-3. PMID: 17679627.
      View in: PubMed
    25. Hurlburt HM, Aurigemma GP, Hill JC, Narayanan A, Gaasch WH, Vinch CS, Meyer TE, Tighe DA. Direct ultrasound measurement of longitudinal, circumferential, and radial strain using 2-dimensional strain imaging in normal adults. Echocardiography. 2007 Aug; 24(7):723-31. PMID: 17651101.
      View in: PubMed
    26. Bermudez EA, Gaasch WH. Regurgitant lesions of the aortic and mitral valves: considerations in determining the ideal timing of surgical intervention. Heart Fail Clin. 2006 Oct; 2(4):473-82. PMID: 17448434.
      View in: PubMed
    27. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation. 2006 Aug 1; 114(5):e84-231. PMID: 16880336.
      View in: PubMed
    28. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2006 Aug 1; 48(3):e1-148. PMID: 16875962.
      View in: PubMed
    29. Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation. 2006 Jan 17; 113(2):296-304. PMID: 16418449.
      View in: PubMed
    30. Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation. 2005 May 10; 111(18):2306-12. PMID: 15851588.
      View in: PubMed
    31. Chung EH, Gaasch WH. Exercise testing in aortic stenosis. Curr Cardiol Rep. 2005 Mar; 7(2):105-7. PMID: 15717956.
      View in: PubMed
    32. Yturralde RF, Gaasch WH. Diagnostic criteria for diastolic heart failure. Prog Cardiovasc Dis. 2005 Mar-Apr; 47(5):314-9. PMID: 16003646.
      View in: PubMed
    33. Aurigemma GP, Gaasch WH. Low flow-low gradient aortic stenosis: the pathologist weighs in. J Am Coll Cardiol. 2004 Nov 2; 44(9):1856-8. PMID: 15519019.
      View in: PubMed
    34. Aurigemma GP, Gaasch WH. Clinical practice. Diastolic heart failure. N Engl J Med. 2004 Sep 9; 351(11):1097-105. PMID: 15356307.
      View in: PubMed
    35. Aurigemma GP, Zile MR, Gaasch WH. Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. Am Heart J. 2004 Sep; 148(3):E12. PMID: 15389248.
      View in: PubMed
    36. Zile M, Gaasch W, Little W, Francis G, Tavazzi L, Cleland J, Davies M. A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design. J Card Fail. 2004 Jun; 10(3):193-9. PMID: 15190528.
      View in: PubMed
    37. Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004 May 6; 350(19):1953-9. PMID: 15128895.
      View in: PubMed
    38. Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med. 2004; 55:373-94. PMID: 14746527.
      View in: PubMed
    39. Zile MR, Gaasch WH. Heart failure in aortic stenosis - improving diagnosis and treatment. N Engl J Med. 2003 May 1; 348(18):1735-6. PMID: 12724478.
      View in: PubMed
    40. Vinch CS, Aurigemma GP, Hill JC, Gaasch WH, Volturo G, Tighe DA, Meyer TE. Usefulness of clinical variables, echocardiography, and levels of brain natriuretic peptide and norepinephrine to distinguish systolic and diastolic causes of acute heart failure. Am J Cardiol. 2003 May 1; 91(9):1140-3. PMID: 12714167.
      View in: PubMed
    41. Gaasch WH, Schick EC. Symptoms and left ventricular size and function in patients with chronic aortic regurgitation. J Am Coll Cardiol. 2003 Apr 16; 41(8):1325-8. PMID: 12706928.
      View in: PubMed
    42. Gaasch WH, Brooks WW, Peralta AO, John RM, Conrad CH, Bing OH. Potentiation of atrial contractility by paired pacing augments ventricular preload and systolic performance. J Card Fail. 2003 Apr; 9(2):141-6. PMID: 12751135.
      View in: PubMed
    43. Mathew RK, Gaasch WH, Guilmette NE, Schick EC, Labib SB. Anthropometric normalization of left ventricular size in chronic mitral regurgitation. Am J Cardiol. 2003 Mar 15; 91(6):762-4. PMID: 12633821.
      View in: PubMed
    44. Hein S, Gaasch WH, Schaper J. Giant molecule titin and myocardial stiffness. Circulation. 2002 Sep 10; 106(11):1302-4. PMID: 12221041.
      View in: PubMed
    45. Brooks WW, Bing OH, Gaasch WH, Karlinsky JB, Goldstein RH, Conrad CH. Comparison of contractile function of diaphragm and cardiac muscle in response to paired electrical stimulation. Comp Biochem Physiol A Mol Integr Physiol. 2002 Sep; 133(1):53-62. PMID: 12160872.
      View in: PubMed
    46. Gaasch WH, Aurigemma GP. Inhibition of the renin-angiotensin system and the left ventricular adaptation to mitral regurgitation. J Am Coll Cardiol. 2002 Apr 17; 39(8):1380-3. PMID: 11955859.
      View in: PubMed
    47. Norton GR, Woodiwiss AJ, Gaasch WH, Mela T, Chung ES, Aurigemma GP, Meyer TE. Heart failure in pressure overload hypertrophy. The relative roles of ventricular remodeling and myocardial dysfunction. J Am Coll Cardiol. 2002 Feb 20; 39(4):664-71. PMID: 11849866.
      View in: PubMed
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