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Nicholas A Smyrnios MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionPulmonary Medicine

    Collapse Biography 
    Collapse education and training
    Tufts University, Medford, MA, United StatesBSBiology
    Albany Medical College, Albany, NY, United StatesMD

    Collapse Overview 
    Collapse overview
    Photo: Nicholas 
A. Smyrnios, M.D.

    Academic Positions

    Associate Division Chief, Pulmonary, Allergy& Critial Care Medicine
    Director, Medical Intensive Care Unit (University Campus)

    Research Interests

    Critical care resource utilization
    Nutrition in critical illness
    Chronic cough
    Lung disease in the elderly

    Medical School

    Albany Medical College of Union University, 1985


    Albany Medical Center Hospital, 1986


    Albany Medical Center Hospital, 1988


    Fellowship in Pulmonary Diseases
    University of Massachusetts Medical Center, 1990

    Fellowship in Critical Care Medicine
    University of Massachusetts Medical Center, 1991

    Board Certifications

    Diplomate of the American Board of Internal Medicine, 1988
    American Board of Internal Medicine,
    Certification in Pulmonary Diseases, 1990, 2000
    American Board of Internal Medicine,
    Certification in Critical Care Medicine, 1991, 2001


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Baldor DJ, Smyrnios NA, Faris K, Guilarte-Walker Y, Celik U, Torres U. A Controlled Study in CPR-Survival in Propensity Score Matched Full-Code and Do-Not-Resuscitate ICU Patients. J Intensive Care Med. 2022 Oct; 37(10):1363-1369. PMID: 35815880.
      Citations:    Fields:    Translation:Humans
    2. Fernald MM, Smyrnios NA, Vitello J. Early Mobility for Critically Ill Patients: Building Staff Commitment Through Appreciative Inquiry. Crit Care Nurse. 2020 Aug 01; 40(4):66-72. PMID: 32737490.
      Citations:    Fields:    Translation:Humans
    3. Rebesco MR, Pinkston MC, Smyrnios NA, Weisberg SN. A Comparison of Non-Invasive Blood Pressure Measurement Strategies with Intra-Arterial Measurement. Prehosp Disaster Med. 2020 Oct; 35(5):516-523. PMID: 32690122.
      Citations: 3     Fields:    Translation:Humans
    4. Smyrnios NA, Lenard R, Rajan S, Newman MS, Baker SP, Thakkar N, Wassef W, Ajmere NK, Irwin RS. Comparison of a self-inflating bulb syringe and a colorimetric CO2 indicator with capnography and radiography to detect the misdirection of naso/orogastric tubes into the airway of critically ill adult patients. Chest. 2015 Jun; 147(6):1523-1529. PMID: 25674721.
      Citations:    Fields:    Translation:HumansAnimals
    5. Boeck L, Eggimann P, Smyrnios N, Pargger H, Thakkar N, Siegemund M, Morgenthaler NG, Rakic J, Tamm M, Stolz D. The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia. J Crit Care. 2012 Oct; 27(5):523.e1-9. PMID: 21958973.
      Citations: 10     Fields:    Translation:Humans
    6. Boeck L, Graf R, Eggimann P, Pargger H, Raptis DA, Smyrnios N, Thakkar N, Siegemund M, Rakic J, Tamm M, Stolz D. Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia. Chest. 2011 Oct; 140(4):925-932. PMID: 21835904.
      Citations: 25     Fields:    Translation:Humans
    7. Boeck L, Eggimann P, Smyrnios N, Pargger H, Thakkar N, Siegemund M, Marsch S, Rakic J, Tamm M, Stolz D. Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP. Eur Respir J. 2011 Mar; 37(3):595-603. PMID: 20530040.
      Citations: 9     Fields:    Translation:Humans
    8. Stolz D, Smyrnios N, Eggimann P, Pargger H, Thakkar N, Siegemund M, Marsch S, Azzola A, Rakic J, Mueller B, Tamm M. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study. Eur Respir J. 2009 Dec; 34(6):1364-75. PMID: 19797133.
      Citations: 104     Fields:    Translation:Humans
    9. Smyrnios NA, Schaefer OP, Collins RM, Madison JM. Applicability of prediction rules in patients with community-acquired pneumonia requiring intensive care: a pilot study. J Intensive Care Med. 2005 Jul-Aug; 20(4):226-32. PMID: 16061905.
      Citations: 1     Fields:    Translation:Humans
    10. Heard SO, Longtine K, Toth I, Puyana JC, Potenza B, Smyrnios N. The influence of liposome-encapsulated prostaglandin E1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome. Anesth Analg. 1999 Aug; 89(2):353-7. PMID: 10439747.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    11. Smyrnios NA, Irwin RS, Curley FJ, French CL. From a prospective study of chronic cough: diagnostic and therapeutic aspects in older adults. Arch Intern Med. 1998 Jun 08; 158(11):1222-8. PMID: 9625401.
      Citations: 12     Fields:    Translation:Humans
    12. Smyrnios NA, Irwin RS. The jury on femoral vein catheterization is still out. Crit Care Med. 1997 Dec; 25(12):1943-6. PMID: 9403738.
      Citations:    Fields:    Translation:Humans
    13. Irwin RS, French CT, Smyrnios NA, Curley FJ. Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch Intern Med. 1997 Sep 22; 157(17):1981-7. PMID: 9308510.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    14. Smyrnios NA, Curley FJ, Shaker KG. Accuracy of 30-minute indirect calorimetry studies in predicting 24-hour energy expenditure in mechanically ventilated, critically ill patients. JPEN J Parenter Enteral Nutr. 1997 May-Jun; 21(3):168-74. PMID: 9168370.
      Citations: 5     Fields:    Translation:Humans
    15. Smyrnios NA. Asthma: a six-part strategy for managing older patients. Geriatrics. 1997 Feb; 52(2):36-40, 42-4. PMID: 9053385.
      Citations: 1     Fields:    Translation:Humans
    16. Smyrnios NA, Irwin RS, Curley FJ. Chronic cough with a history of excessive sputum production. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Chest. 1995 Oct; 108(4):991-7. PMID: 7555175.
      Citations: 37     Fields:    Translation:Humans
    17. Smyrnios NA, Jederlinic PJ, Irwin RS. Pleural effusion in an asymptomatic patient. Spectrum and frequency of causes and management considerations. Chest. 1990 Jan; 97(1):192-6. PMID: 2403896.
      Citations: 2     Fields:    Translation:Humans
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