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Nadia Amrani PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentRNA Therapeutics Institute
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    Cadi Ayyad University, Marrakesh, , MoroccoBSScience
    Ecole Nationale Supérieure de Formation de l'Enseignement Agricole, Toulouse, , FranceMSBiotechnology
    Pierre and Marie Curie University, Paris, , FrancePHDMolecular Genetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol Cell. 2019 Oct 22. PMID: 31668930.
      View in: PubMed
    2. Fassi Fihri O, Jammar N, Amrani N, El Berbri I, Alali S. Sheep pestivirus in Morocco: sero-epidemiological and molecular study. Vet Rec Open. 2019; 6(1):e000324. PMID: 31565228.
      View in: PubMed
    3. Babu K, Amrani N, Jiang W, Yogesha SD, Nguyen R, Qin PZ, Rajan R. Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance. Biochemistry. 2019 Mar 27. PMID: 30916546.
      View in: PubMed
    4. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 12 10; 9(1):5294. PMID: 30531933.
      View in: PubMed
    5. Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biol. 2018 Dec 05; 19(1):214. PMID: 30518407.
      View in: PubMed
    6. Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. MBio. 2018 Dec 04; 9(6). PMID: 30514786.
      View in: PubMed
    7. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 Nov 19; 9(1):4856. PMID: 30451839.
      View in: PubMed
    8. Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018 Sep 19; 19(1):137. PMID: 30231914.
      View in: PubMed
    9. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. 2017 Sep 07; 170(6):1224-1233.e15. PMID: 28844692.
      View in: PubMed
    10. Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. Naturally Occurring Off-Switches for CRISPR-Cas9. Cell. 2016 Dec 15; 167(7):1829-1838.e9. PMID: 27984730.
      View in: PubMed
    11. Amrani N, Desario C, Kadiri A, Cavalli A, Berrada J, Zro K, Sebbar G, Colaianni ML, Parisi A, Elia G, Buonavoglia C, Malik J, Decaro N. Molecular epidemiology of canine parvovirus in Morocco. Infect Genet Evol. 2016 Jul; 41:201-6. PMID: 27083072.
      View in: PubMed
    12. Min EE, Roy B, Amrani N, He F, Jacobson A. Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA. 2013 Aug; 19(8):1105-15. PMID: 23801788.
      View in: PubMed
    13. Ghosh S, Ganesan R, Amrani N, Jacobson A. Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA. 2010 Sep; 16(9):1832-47. PMID: 20675403.
      View in: PubMed
    14. Amrani N, Ghosh S, Mangus DA, Jacobson A. Translation factors promote the formation of two states of the closed-loop mRNP. Nature. 2008 Jun 26; 453(7199):1276-80. PMID: 18496529.
      View in: PubMed
    15. He F, Amrani N, Johansson MJ, Jacobson A. Chapter 6. Qualitative and quantitative assessment of the activity of the yeast nonsense-mediated mRNA decay pathway. Methods Enzymol. 2008; 449:127-47. PMID: 19215756.
      View in: PubMed
    16. Wu C, Amrani N, Jacobson A, Sachs MS. The use of fungal in vitro systems for studying translational regulation. Methods Enzymol. 2007; 429:203-25. PMID: 17913625.
      View in: PubMed
    17. Amrani N, Sachs MS, Jacobson A. Early nonsense: mRNA decay solves a translational problem. Nat Rev Mol Cell Biol. 2006 Jun; 7(6):415-25. PMID: 16723977.
      View in: PubMed
    18. Kervestin S, Amrani N. Translational regulation of gene expression. Genome Biol. 2004; 5(12):359. PMID: 15575982.
      View in: PubMed
    19. Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, Jacobson A. A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature. 2004 Nov 4; 432(7013):112-8. PMID: 15525991.
      View in: PubMed
    20. Sachs MS, Wang Z, Gaba A, Fang P, Belk J, Ganesan R, Amrani N, Jacobson A. Toeprint analysis of the positioning of translation apparatus components at initiation and termination codons of fungal mRNAs. Methods. 2002 Feb; 26(2):105-14. PMID: 12054887.
      View in: PubMed
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