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Nadia Amrani PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    Collapse Biography 
    Collapse education and training
    Cadi Ayyad University, Marrakesh, , MoroccoBSScience
    Ecole Nationale Supérieure de Formation de l'Enseignement Agricole, Toulouse, , FranceMSBiotechnology
    Pierre and Marie Curie University, Paris, , FrancePHDMolecular Genetics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Res. 2024 Jan 25; 52(2):977-997. PMID: 38033325.
      Citations:    Fields:    Translation:Animals
    2. Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodr?guez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. PAM-flexible genome editing with an engineered chimeric Cas9. Nat Commun. 2023 10 04; 14(1):6175. PMID: 37794046.
      Citations:    Fields:    
    3. Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez T, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Res Sq. 2023 Mar 07. PMID: 36945419.
    4. Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nat Commun. 2021 Nov 26; 12(1):6931. PMID: 34836963.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    5. Rodr?guez TC, Dadafarin S, Pratt HE, Liu P, Amrani N, Zhu LJ. Genome-wide detection and analysis of CRISPR-Cas off-targets. Prog Mol Biol Transl Sci. 2021; 181:31-43. PMID: 34127199.
      Citations: 7     Fields:    Translation:Humans
    6. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodr?guez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity. Nat Biotechnol. 2020 Oct; 38(10):1212. PMID: 32561876.
      Citations: 1     Fields:    
    7. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodr?guez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. An engineered ScCas9 with broad PAM range and high specificity and activity. Nat Biotechnol. 2020 10; 38(10):1154-1158. PMID: 32393822.
      Citations: 46     Fields:    Translation:Cells
    8. Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol Cell. 2019 Dec 19; 76(6):938-952.e5. PMID: 31668930.
      Citations: 44     Fields:    Translation:Cells
    9. Fassi Fihri O, Jammar N, Amrani N, El Berbri I, Alali S. Sheep pestivirus in Morocco: sero-epidemiological and molecular study. Vet Rec Open. 2019; 6(1):e000324. PMID: 31565228.
    10. Babu K, Amrani N, Jiang W, Yogesha SD, Nguyen R, Qin PZ, Rajan R. Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance. Biochemistry. 2019 Apr 09; 58(14):1905-1917. PMID: 30916546.
      Citations: 16     Fields:    Translation:Cells
    11. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 12 10; 9(1):5294. PMID: 30531933.
      Citations:    Fields:    
    12. Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biol. 2018 12 05; 19(1):214. PMID: 30518407.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    13. Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. mBio. 2018 12 04; 9(6). PMID: 30514786.
      Citations: 43     Fields:    Translation:HumansCells
    14. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 11 19; 9(1):4856. PMID: 30451839.
      Citations: 19     Fields:    Translation:HumansCells
    15. Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018 09 19; 19(1):137. PMID: 30231914.
      Citations: 52     Fields:    Translation:AnimalsCells
    16. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. 2017 Sep 07; 170(6):1224-1233.e15. PMID: 28844692.
      Citations: 111     Fields:    Translation:HumansCells
    17. Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. Naturally Occurring Off-Switches for CRISPR-Cas9. Cell. 2016 Dec 15; 167(7):1829-1838.e9. PMID: 27984730.
      Citations: 183     Fields:    Translation:HumansCells
    18. Amrani N, Desario C, Kadiri A, Cavalli A, Berrada J, Zro K, Sebbar G, Colaianni ML, Parisi A, Elia G, Buonavoglia C, Malik J, Decaro N. Molecular epidemiology of canine parvovirus in Morocco. Infect Genet Evol. 2016 07; 41:201-206. PMID: 27083072.
      Citations: 14     Fields:    Translation:AnimalsCells
    19. Min EE, Roy B, Amrani N, He F, Jacobson A. Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA. 2013 Aug; 19(8):1105-15. PMID: 23801788.
      Citations: 24     Fields:    Translation:AnimalsCells
    20. Ghosh S, Ganesan R, Amrani N, Jacobson A. Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA. 2010 Sep; 16(9):1832-47. PMID: 20675403.
      Citations: 33     Fields:    Translation:AnimalsCells
    21. Amrani N, Ghosh S, Mangus DA, Jacobson A. Translation factors promote the formation of two states of the closed-loop mRNP. Nature. 2008 Jun 26; 453(7199):1276-80. PMID: 18496529.
      Citations: 113     Fields:    Translation:AnimalsCells
    22. He F, Amrani N, Johansson MJ, Jacobson A. Chapter 6. Qualitative and quantitative assessment of the activity of the yeast nonsense-mediated mRNA decay pathway. Methods Enzymol. 2008; 449:127-47. PMID: 19215756.
      Citations: 17     Fields:    Translation:AnimalsCells
    23. Wu C, Amrani N, Jacobson A, Sachs MS. The use of fungal in vitro systems for studying translational regulation. Methods Enzymol. 2007; 429:203-25. PMID: 17913625.
      Citations: 29     Fields:    Translation:AnimalsCells
    24. Amrani N, Sachs MS, Jacobson A. Early nonsense: mRNA decay solves a translational problem. Nat Rev Mol Cell Biol. 2006 Jun; 7(6):415-25. PMID: 16723977.
      Citations: 133     Fields:    Translation:AnimalsCells
    25. Kervestin S, Amrani N. Translational regulation of gene expression. Genome Biol. 2004; 5(12):359. PMID: 15575982.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    26. Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, Jacobson A. A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature. 2004 Nov 04; 432(7013):112-8. PMID: 15525991.
      Citations: 270     Fields:    Translation:AnimalsCells
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