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Majaz Moonis MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-8572
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology

    InstitutionUMMS - School of Medicine
    DepartmentPsychiatry


    Collapse Biography 
    Collapse education and training
    University of Delhi, Delhi, , IndiaBSBiology
    University of Delhi, Delhi, , IndiaMBBSMedicine and Surgery

    Collapse Overview 
    Collapse overview

    My research focuses on several interrelated areas that affect stroke and dementia outcomes. More specifically I am interested in the following areas: Outcome research related to specific interventions affecting the vascular endothelium in stroke and Alzheimer’s disease; health care disparities relating to race, age and gender in stroke and dementia; optimal management and effects on primary and secondary stroke prevention; genetic markers in cryptogenic stroke to aid in sub-classification and management; clinical trials in acute stroke and stroke prevention; data mining in sleep related disorders; and stroke.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Azeem MU, Nagy M, Miller MM, Ghasemi M, Mikati A, Silver B, Moonis M, Henninger N. Prevalence of a Multiple Territory Stroke Pattern After Intravenous Thrombolysis. J Stroke Cerebrovasc Dis. 2020 Feb 21; 104700. PMID: 32093987.
      View in: PubMed
    2. Silver B, Hamid T, Khan M, DiNapoli M, Behrouz R, Saposnik G, Sarafin JA, Martin S, Moonis M, Henninger N, Goddeau R, Jun-O'Connell A, Cutting SM, Saad A, Yaghi S, Hall W, Muehlschlegel S, Carandang R, Osgood M, Thompson BB, Fehnel CR, Wendell LC, Potter NS, Gilchrist JM, Barton B. 12 versus 24 h bed rest after acute ischemic stroke thrombolysis: a preliminary experience. J Neurol Sci. 2019 Dec 05; 409:116618. PMID: 31837536.
      View in: PubMed
    3. Jayaraman DK, Alcusky M, Moonis M. Letter by Jayaraman et al Regarding Articles, "Higher Incidence of Ischemic Stroke in Patients Taking Novel Oral Anticoagulants" and "Effectiveness and Safety of Oral Anticoagulants among Nonvalvular Atrial Fibrillation Patients: The ARISTOPHANES Study". Stroke. 2019 May 16; STROKEAHA119024817. PMID: 31092166.
      View in: PubMed
    4. Ding EY, Han D, Whitcomb C, Bashar SK, Adaramola O, Soni A, Saczynski J, Fitzgibbons TP, Moonis M, Lubitz SA, Lessard D, Hills MT, Barton B, Chon K, McManus DD. Accuracy and Usability of a Novel Algorithm for Detection of Irregular Pulse Using a Smartwatch Among Older Adults: Observational Study. JMIR Cardio. 2019 May 15; 3(1):e13850. PMID: 31758787.
      View in: PubMed
    5. Mikati AG, Mandelbaum M, Sapnar S, Puri AS, Silver B, Goddeau RP, Haussen DC, Moonis M, Jun-O'Connell AH, Henninger N. Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke. Transl Stroke Res. 2019 Apr 12. PMID: 30980282.
      View in: PubMed
    6. Jun-O'connell AH, Henninger N, Moonis M, Silver B, Ionete C, Goddeau RP. Recrudescence of Old Stroke Deficits Among Transient Neurological Attacks. Neurohospitalist. 2019 Oct; 9(4):183-189. PMID: 31534606.
      View in: PubMed
    7. Miller MM, Lowe J, Khan M, Azeem MU, Muehlschlegel S, Jun-O'Connell AH, Goddeau RP, Moonis M, Gritters D, Silver B, Henninger N. Clinical and Radiological Characteristics of Vitamin K Versus Non-Vitamin K Antagonist Oral Anticoagulation-Related Intracerebral Hemorrhage. Neurocrit Care. 2019 Jan 28. PMID: 30690686.
      View in: PubMed
    8. Nagy M, Azeem MU, Soliman Y, Nawab SA, Jun-O'Connell AH, Goddeau RP, Moonis M, Silver B, Henninger N. Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack. J Stroke Cerebrovasc Dis. 2019 Jan 07. PMID: 30630754.
      View in: PubMed
    9. Moonis M. Editorial: Carotid Revasculatization vs Best Medical Management in Symptomatic Carotid Artery Disease. Ann Indian Acad Neurol. 2018 Jul-Sep; 21(3):171-172. PMID: 30258256.
      View in: PubMed
    10. Husaini BA, Taira D, Norris K, Adhish SV, Moonis M, Levine R. Depression Effects on Hospital Cost of Heart Failure Patients in California: An Analysis by Ethnicity and Gender. Indian J Community Med. 2018 Jan-Mar; 43(1):49-52. PMID: 29531440.
      View in: PubMed
    11. Mayasi Y, Goddeau RP, Moonis M, Silver B, Jun-O'Connell AH, Puri AS, Henninger N. Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales. AJNR Am J Neuroradiol. 2018 Feb; 39(2):317-322. PMID: 29170268.
      View in: PubMed
    12. Mayasi Y, Helenius J, McManus DD, Goddeau RP, Jun-O'Connell AH, Moonis M, Henninger N. Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke. J Neurol Neurosurg Psychiatry. 2017 May 27. PMID: 28554961.
      View in: PubMed
    13. Minaeian A, Patel A, Essa B, Goddeau RP, Moonis M, Henninger N. Emergency Department Length of Stay and Outcome after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 May 24. PMID: 28551289.
      View in: PubMed
    14. Husaini B, Levine R, Lammers P, Hull P, Novotny M, Moonis M. Smoking, depression, and hospital costs of respiratory cancers: Examining race and sex variation. Fam Med Community Health. 2017; 5(1):29-42. PMID: 29057243.
      View in: PubMed
    15. Husaini BA, Levine RS, Norris KC, Cain V, Bazargan M, Moonis M. Heart Failure Hospitalization by Race/Ethnicity, Gender and Age in California: Implications for Prevention. Ethn Dis. 2016 Jul 21; 26(3):345-54. PMID: 27440974.
      View in: PubMed
    16. Mayasi Y, Helenius J, Goddeau RP, Moonis M, Henninger N. Time to Presentation Is Associated with Clinical Outcome in Hemispheric Stroke Patients Deemed Ineligible for Recanalization Therapy. J Stroke Cerebrovasc Dis. 2016 Oct; 25(10):2373-9. PMID: 27315744.
      View in: PubMed
    17. Helenius J, Goddeau RP, Moonis M, Henninger N. Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke. Stroke. 2016 Jan; 47(1):24-30. PMID: 26556825.
      View in: PubMed
    18. Seshadri S, Moonis M. Dipping to clear amyloid: Cerebrovascular reactivity and neurodegeneration--cause or effect? Neurology. 2015 Dec 1; 85(22):1918-9. PMID: 26537050.
      View in: PubMed
    19. Novak P, Pimentel DA, Sundar B, Moonis M, Qin L, Novak V. Association of Statins with Sensory and Autonomic Ganglionopathy. Front Aging Neurosci. 2015; 7:191. PMID: 26500548.
      View in: PubMed
    20. Husaini B, Gudlavalleti AS, Cain V, Levine R, Moonis M. Risk Factors and Hospitalization Costs of Dementia Patients: Examining Race and Gender Variations. Indian J Community Med. 2015 Oct-Dec; 40(4):258-63. PMID: 26435599.
      View in: PubMed
    21. Sundar B, Moonis M, Wakhloo A, Puri A. Bilateral Intracranial Vertebral Artery Stenosis Presenting as Recurrent Prolonged Presyncopal Episodes. Case Rep Neurol Med. 2015; 2015:251536. PMID: 26421200.
      View in: PubMed
    22. Moonis M, Kumar R, Henninger N, Kane K, Fisher M. Pre and Post-stroke Use of Statins Improves Stroke Outcome. Indian J Community Med. 2014 Oct; 39(4):214-7. PMID: 25364144.
      View in: PubMed
    23. Srivastava PV, Sudhan P, Khurana D, Bhatia R, Kaul S, Sylaja PN, Moonis M, Pandian JD. Telestroke a viable option to improve stroke care in India. Int J Stroke. 2014 Oct; 9 Suppl A100:133-4. PMID: 25042038.
      View in: PubMed
    24. Khan M, Goddeau RP, Zhang J, Moonis M, Henninger N. Predictors of Outcome following Stroke due to Isolated M2 Occlusions. Cerebrovasc Dis Extra. 2014 Jan; 4(1):52-60. PMID: 24715898.
      View in: PubMed
    25. Moonis M, Srivastava P, Selim M, Fisher M. Advances and potential new treatments in stroke management. Stroke Res Treat. 2014; 2014:120384. PMID: 24693458.
      View in: PubMed
    26. Henninger N, Khan MA, Zhang J, Moonis M, Goddeau RP. Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion. Stroke. 2014 Mar; 45(3):689-95. PMID: 24523039.
      View in: PubMed
    27. Mehndiratta MM, Singhal A, Chaturvedi S, Sivakumar MR, Moonis M. Author response. Neurology. 2014 Jan 7; 82(1):96. PMID: 24520571.
      View in: PubMed
    28. Ade S, Moonis M. Intracranial hypotension with multiple complications: an unusual case report. Case Rep Neurol Med. 2013; 2013:913465. PMID: 24324901.
      View in: PubMed
    29. Mehndiratta MM, Singhal AB, Chaturvedi S, Sivakumar MR, Moonis M. Meeting the challenges of stroke in India. Neurology. 2013 Jun 11; 80(24):2246-7. PMID: 23751917.
      View in: PubMed
    30. Husaini B, Levine R, Sharp L, Cain V, Novotny M, Hull P, Orum G, Samad Z, Sampson U, Moonis M. Depression increases stroke hospitalization cost: an analysis of 17,010 stroke patients in 2008 by race and gender. Stroke Res Treat. 2013; 2013:846732. PMID: 23555070.
      View in: PubMed
    31. Henninger N, Lin E, Haussen DC, Lehman LL, Takhtani D, Selim M, Moonis M. Leukoaraiosis and sex predict the hyperacute ischemic core volume. Stroke. 2013 Jan; 44(1):61-7. PMID: 23233384.
      View in: PubMed
    32. Fisher M, Moonis M. Neuroprotective effects of statins: evidence from preclinical and clinical studies. Curr Treat Options Cardiovasc Med. 2012 Jun; 14(3):252-9. PMID: 22362392.
      View in: PubMed
    33. Moonis M. High-dose statins should be used in all acute ischemic strokes. Stroke. 2012 Jul; 43(7):1992-3. PMID: 22569933.
      View in: PubMed
    34. Henninger N, Lin E, Baker SP, Wakhloo AK, Takhtani D, Moonis M. Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis. 2012; 33(6):525-31. PMID: 22538962.
      View in: PubMed
    35. Cachia D, Swearer J, Ferguson W, Moonis M. Selective cognitive patterns resulting from bilateral hippocampal ischemia. Arch Med Sci. 2011 Feb; 7(1):168-72. PMID: 22291752.
      View in: PubMed
    36. Dangayach NS, Kane K, Moonis M. Paroxysmal atrial fibrillation in cryptogenic stroke. Ther Clin Risk Manag. 2011; 7:33-7. PMID: 21339941.
      View in: PubMed
    37. Pollen DA, Baker S, Hinerfeld D, Swearer J, Evans BA, Evans JE, Caselli R, Rogaeva E, St George-Hyslop P, Moonis M. Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4. Alzheimers Res Ther. 2010 Oct 29; 2(5):31. PMID: 21062519.
      View in: PubMed
    38. Lin E, Padmanabhan R, Moonis M. Antiplatelet agents and proton pump inhibitors - personalizing treatment. Pharmgenomics Pers Med. 2010; 3:101-9. PMID: 23226046.
      View in: PubMed
    39. Titelbaum DS, Sodha NB, Moonis M. Transient hemiglossal denervation during acute internal capsule infarct in the setting of dysarthria-clumsy hand syndrome. AJNR Am J Neuroradiol. 2010 Aug; 31(7):1266-7. PMID: 20007722.
      View in: PubMed
    40. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14. PMID: 19546536.
      View in: PubMed
    41. Evans BA, Evans JE, Baker SP, Kane K, Swearer J, Hinerfeld D, Caselli R, Rogaeva E, St George-Hyslop P, Moonis M, Pollen DA. Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease. Dement Geriatr Cogn Disord. 2009; 27(6):519-24. PMID: 19478483.
      View in: PubMed
    42. Moonis M. Intraarterial thrombolysis within the first three hours after acute ischemic stroke in selected patients. Stroke. 2009 Jul; 40(7):2611-2. PMID: 19443796.
      View in: PubMed
    43. Duffis EJ, Jones D, Tighe D, Moonis M. Neurological complications of coronary angiographic procedures. Expert Rev Cardiovasc Ther. 2007 Nov; 5(6):1113-21. PMID: 18035927.
      View in: PubMed
    44. Hinerfeld DA, Moonis M, Swearer JM, Baker SP, Caselli RJ, Rogaeva E, St George-Hyslop P, Pollen DA. Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects. Arch Neurol. 2007 Nov; 64(11):1672-3. PMID: 17998454.
      View in: PubMed
    45. Patel D, Moonis M. Clinical implications of aspirin resistance. Expert Rev Cardiovasc Ther. 2007 Sep; 5(5):969-75. PMID: 17867925.
      View in: PubMed
    46. Klunk WE, Price JC, Mathis CA, Tsopelas ND, Lopresti BJ, Ziolko SK, Bi W, Hoge JA, Cohen AD, Ikonomovic MD, Saxton JA, Snitz BE, Pollen DA, Moonis M, Lippa CF, Swearer JM, Johnson KA, Rentz DM, Fischman AJ, Aizenstein HJ, DeKosky ST. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J Neurosci. 2007 Jun 6; 27(23):6174-84. PMID: 17553989.
      View in: PubMed
    47. Laxminarayan P, Alvarez SA, Ruiz C, Moonis M. Mining statistically significant associations for exploratory analysis of human sleep data. IEEE Trans Inf Technol Biomed. 2006 Jul; 10(3):440-50. PMID: 16871710.
      View in: PubMed
    48. Padma V, Fisher M, Moonis M. Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke. Expert Rev Cardiovasc Ther. 2006 May; 4(3):405-15. PMID: 16716101.
      View in: PubMed
    49. Moonis M, Swearer JM, Dayaw MP, St George-Hyslop P, Rogaeva E, Kawarai T, Pollen DA. Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline. Neurology. 2005 Jul 26; 65(2):323-5. PMID: 16043812.
      View in: PubMed
    50. Moonis M, Kane K, Schwiderski U, Sandage BW, Fisher M. HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke. 2005 Jun; 36(6):1298-300. PMID: 15879346.
      View in: PubMed
    51. Padma V, Fisher M, Moonis M. Thrombolytic therapy for acute ischemic stroke: 3 h and beyond. Expert Rev Neurother. 2005 Mar; 5(2):223-33. PMID: 15853492.
      View in: PubMed
    52. Padma V, Fisher M, Moonis M. Antihypertensive medications for risk reduction of first and recurrent ischemic stroke. Expert Rev Cardiovasc Ther. 2004 Nov; 2(6):867-76. PMID: 15500432.
      View in: PubMed
    53. Moonis M, Fisher M. HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after stroke. Expert Rev Neurother. 2004 Mar; 4(2):241-7. PMID: 15853565.
      View in: PubMed
    54. Moonis M, Fisher M. Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use. Expert Rev Cardiovasc Ther. 2003 Nov; 1(4):611-5. PMID: 15030260.
      View in: PubMed
    55. Husaini BA, Sherkat DE, Moonis M, Levine R, Holzer C, Cain VA. Racial differences in the diagnosis of dementia and in its effects on the use and costs of health care services. Psychiatr Serv. 2003 Jan; 54(1):92-6. PMID: 12509673.
      View in: PubMed
    56. Moonis M, Fisher M. Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke. Stroke. 2002 Jul; 33(7):1927-33. PMID: 12105378.
      View in: PubMed
    57. Moonis M, Lee B, Bailer RT, Luo Q, Montaner LJ. CCR5 and CXCR4 expression correlated with X4 and R5 HIV-1 infection yet not sustained replication in Th1 and Th2 cells. AIDS. 2001 Oct 19; 15(15):1941-9. PMID: 11600821.
      View in: PubMed
    58. Moonis M, Fisher M. [Imaging of acute stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2001; (Suppl 2):4-11. PMID: 12830523.
      View in: PubMed
    59. Moonis M, Fisher M. Imaging of acute stroke. Cerebrovasc Dis. 2001; 11(3):143-50. PMID: 11306759.
      View in: PubMed
    60. Papasavvas E, Ortiz GM, Gross R, Sun J, Moore EC, Heymann JJ, Moonis M, Sandberg JK, Drohan LA, Gallagher B, Shull J, Nixon DF, Kostman JR, Montaner LJ. Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption. J Infect Dis. 2000 Sep; 182(3):766-75. PMID: 10950770.
      View in: PubMed
    61. Selvaraj N, Moonis M, Ravin P. Hemiparesis following influenza vaccination. Postgrad Med J. 1998 Oct; 74(876):633-5. PMID: 10211371.
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    62. Drachman DA, Swearer JM, Kane K, Osgood D, O'Toole C, Moonis M. The cognitive assessment screening test (CAST) for dementia. J Geriatr Psychiatry Neurol. 1996 Oct; 9(4):200-8. PMID: 8970013.
      View in: PubMed
    63. Moonis M, Smith TW. Meningeal gliomatosis presenting as multiple cerebral infarcts: a case report. Neurology. 1996 Jun; 46(6):1760-2. PMID: 8649589.
      View in: PubMed
    64. Merrill DP, Moonis M, Chou TC, Hirsch MS. Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro. J Infect Dis. 1996 Feb; 173(2):355-64. PMID: 8568296.
      View in: PubMed
    65. Rusconi S, Moonis M, Merrill DP, Pallai PV, Neidhardt EA, Singh SK, Willis KJ, Osburne MS, Profy AT, Jenson JC, Hirsch MS. Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities. Antimicrob Agents Chemother. 1996 Jan; 40(1):234-6. PMID: 8787913.
      View in: PubMed
    66. Cohen RA, O'Donnell BF, Meadows ME, Moonis M, Stone WF, Drachman DA. ERP indices and neuropsychological performance as predictors of functional outcome in dementia. J Geriatr Psychiatry Neurol. 1995 Oct; 8(4):217-25. PMID: 8561835.
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    67. Mazzulli T, Rusconi S, Merrill DP, D'Aquila RT, Moonis M, Chou TC, Hirsch MS. Alternating versus continuous drug regimens in combination chemotherapy of human immunodeficiency virus type 1 infection in vitro. Antimicrob Agents Chemother. 1994 Apr; 38(4):656-61. PMID: 8031028.
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    68. Moonis M, Ahmad I, Bachhawat BK. Effect of elimination of phagocytic cells by liposomal dichloromethylene diphosphonate on aspergillosis virulence and toxicity of liposomal amphotericin B in mice. J Antimicrob Chemother. 1994 Mar; 33(3):571-83. PMID: 8040121.
      View in: PubMed
    69. Moonis M, Ahmad I, Bachhawat BK. Liposomal hamycin in the control of experimental aspergillosis in mice: effect of phosphatidic acid with and without cholesterol. J Antimicrob Chemother. 1993 Apr; 31(4):569-79. PMID: 8514651.
      View in: PubMed
    70. Moonis M, Ahmad I, Bachhawat BK. Mannosylated liposomes as carriers for hamycin in the treatment of experimental aspergillosis in Balb/C mice. J Drug Target. 1993; 1(2):147-55. PMID: 8069553.
      View in: PubMed
    71. Moonis M, Ahmad I, Bachhawat BK. Liposomal hamycin in the control of experimental aspergillosis in mice: relative toxicity, therapeutic efficacy and tissue distribution of free and liposomal hamycin. Indian J Biochem Biophys. 1992 Aug; 29(4):339-45. PMID: 1427960.
      View in: PubMed
    72. Moonis M, Ahmad I, Bachhawat BK. Macrophages in host defence--an overview. Indian J Biochem Biophys. 1992 Apr; 29(2):115-22. PMID: 1328034.
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    73. Moonis M, Jain S, Kalra V, Ahuja GK. Local tetanus initially mistaken as compressive thoracic myelopathy: a case report with electrophysiological findings. Indian Pediatr. 1991 Nov; 28(11):1333-6. PMID: 1808060.
      View in: PubMed
    74. Sachdev HP, Sachdev MS, Verma L, Sood NN, Moonis M. Electrophysiological studies of the eye, peripheral nerves and muscles in epidemic dropsy. J Trop Med Hyg. 1989 Dec; 92(6):412-5. PMID: 2607575.
      View in: PubMed
    75. Moonis M, Gupta R, Kumar K, Bihari M, Prasad K, Goulatia RK, Ahuja GK. Proximal myopathy as a presenting feature in hyperparathyroidism. Indian Pediatr. 1988 Jul; 25(7):694-8. PMID: 3220552.
      View in: PubMed
    76. Moonis M, Jain S, Prasad K, Mishra NK, Goulatia RK, Maheshwari MC. Left thalamic hypertensive haemorrhage presenting as transient global amnesia. Acta Neurol Scand. 1988 Apr; 77(4):331-4. PMID: 3389083.
      View in: PubMed
    77. Sachdev MS, Verma L, Garg SP, Moonis M, Shekar CH, Gupta NK. Bilateral disc oedema in retinitis pigmentosa--an unusual sign. Jpn J Ophthalmol. 1987; 31(4):621-6. PMID: 3448326.
      View in: PubMed
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