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Michael Paul Czech PhD

TitleProfessor Emeritus
Endowed TitleIsadore and Fannie Foxman Chair in Medical Research
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 100
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology

    Collapse Biography 
    Collapse education and training
    Brown University, Providence, RI, United StatesBAChemistry
    Duke University, Durham, NC, United StatesMABiochemistry
    Brown University, Providence, RI, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse overview

    Michael P. Czech is currently the Isadore and Fannie Foxman Chair of Medical Research in the Program in Molecular Medicine at the University of Massachusetts Medical School. He was Chair of the Department of Biochemistry from 1981 to 1989, and was the founding Chair of the Program in Molecular Medicine (1989-2018). Czech earned the PhD degree in biochemistry in 1972 at Brown University under the mentorship of Professor John Fain, and completed postdoctoral study at Duke University Medical Center. He became Assistant Professor at Brown in 1974, rising to the rank of Professor in 1980. His research addresses mechanisms of signal transduction, metabolism and insulin resistance in type 2 diabetes and obesity. Czech’s laboratory has recently applied RNAi and CRISPR techniques to discover novel drug targets and to develop therapeutic strategies for alleviating inflammatory and metabolic diseases.

    Czech has served on several editorial boards and NIH Study Sections and is a member of the Scientific Review Board of the Howard Hughes Medical Institute. He has received the Scientific Achievement Award (1982), the Banting Medal (2000) and the Albert Renold Award for mentorship (2004) from the American Diabetes Association; the David Rumbough Scientific Award of the Juvenile Diabetes Foundation (1985); NIH MERIT Awards (1997-2005 and 2012-2022); the Elliot P. Joslin Medal (1998), and the Jacobaeus Prize awarded in Umea, Sweden in 2009.

    Czech Lab Research:

    Gene editing and deletion to enhance insulin sensitivity in type 2 diabetes and obesity.

    Major human diseases such as type 2 diabetes and atherosclerosis are promoted by dysfunctions in adipose tissue and in the interactions between adipocytes, endothelial cells, nerve fibers and immune cells. Adipose tissue remodeling in obesity can also secondarily disrupt liver and skeletal muscle metabolism, causing systemic insulin resistance and glucose intolerance. Our laboratory group is attacking key questions related to these cellular and molecular interactions among metabolic tissues, macrophages, neuronal signals and the vasculature that define both normal and metabolic disease states.

    Central questions for our laboratory group are:

     Can we identify molecular mechanisms that disrupt insulin signaling in obesity and type 2 diabetes to develop therapeutic strategies for these diseases?

     Can we identify and modulate molecular mechanisms that switch adipocytes from storing triglyceride to cells that oxidize fat, expend energy and secrete beneficial factors?

     Can we target genes that promote fatty liver and inflammation in obesity and diabetes with therapeutic siRNA to alleviate nonalcoholic steatohepatitis (NASH)?

    Many of our projects take advantage of CRISPR and RNA interference (RNAi) to selectively silence normal or disease genes in vivo, providing both powerful research tools and potential approaches to therapies. Experiments in our laboratory are currently devoted to developing CRISPR- and siRNA-based delivery particles that can beneficially alter gene expression in adipocytes, hepatocytes and other cell types. Using these techniques, we have recently shown that gene editing of adipocytes by CRISPR can enhance their energy expenditure and fat oxidation. These efforts are advancing toward therapeutic applications.

    Another approach that we have developed in collaboration with the Gary Ostroff laboratory is a method to deliver siRNA in vivo using glucan encapsulation vehicles (GeRPs).  GeRPs can target macrophages in adipose tissue and liver to silence genes and attenuate tissue inflammation and insulin resistance.





    Collapse Rotation Projects


     The Czech laboratory is active in mentoring graduate students and postdoctoral fellows.

    Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include:

    Paul Pilch, Professor of Biochemistry, Boston University School of Medicine

    Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine

    Joan Massague,  Director, Sloan Kettering Institute

    Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School

    Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School

    Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute

    Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center

    Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center

    Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center

    Assia Shisheva, Professor of Physiology, Wayne State School of Medicine.

    Mark Sleeman, Professor of Physiology, Monash University, Australia

    John Harris, Associate Professor of Medicine, UMASS Medical School

    Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University

    Vishu Puri, Professor of Biomedical Sciences, Ohio University

    Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center

    Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School

    Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute

    Adilson Guilherme, Associate Professor, University of Massachusetts Medical School


    Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research Projects for students following a rotation:

    Developing CRISPR technology for gene editing in adipocytes: Adipocytes function as master regulators of whole body metabolism and deletions of specific adipocyte genes in knockout mice promote dramatic improvements in glucose tolerance and insulin sensitivity in diabetic models. Thus the ability to direct gene editing in adipocytes in vivo has great potential in developing therapeutic strategies for obesity, type 2 diabetes and cardiovascular complications. Alternatively, an ex vivo approach is also feasible since adipose cells can be genetically altered in vitro prior to implantation into mice with beneficial effects. Such projects are designed to be performed in collaboration with other Czech lab members with the goal of specifically deleting or editing genes in adipose depots that drive increases in fatty acid oxidation, energy expenditure and systemic metabolic activity. Exciting preliminary data at the “proof of principle” stage has been achieved and this project is designed to focus on specific genes of high interest for therapeutics.

    Signaling by the lipogenesis pathway through Acetyl CoA: A major function of adipocytes is to store calories as triglyceride, in part through the process of fatty acid synthesis (lipogenesis). This metabolic pathway involves a number of metabolites including Acetyl CoA, which is also a substrate for acetylation reactions that modify proteins such as histones. Thus metabolic flux through adipocyte lipogenesis may also function as a signaling pathway to the nucleus to modulate transcription via levels of Acetyl CoA that accumulate during this process. This rotation project is designed to test this idea at the molecular level by monitoring histone acetylations and resultant transcriptional events during changes in Acetyl CoA levels caused by altering physiological conditions such as exercise, obesity and diabetes. If this concept is correct, the project could lead to developing therapeutic strategies for metabolic disease based on targeting lipogenic enzymes.






    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, Wang H, McHugh N, Bramato B, Morrison B, Rothstein JD, Khvorova A, Czech MP. Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis. Elife. 2024 Apr 02; 12. PMID: 38564479.
    2. Nandy A, Helderman RCM, Thapa S, Jayapalan S, Richards A, Narayani N, Czech MP, Rosen CJ, Rendina-Ruedy E. Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status. Bone Res. 2023 11 24; 11(1):62. PMID: 38001111.
    3. Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, Wang H, McHugh N, Bramato B, Morrision B, Rothstein JD, Khvorova A, Czech MP. Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis. bioRxiv. 2023 Oct 19. PMID: 37205462.
    4. Rowland LA, Czech MP. Fatty acid availability controls autophagy and associated cell functions. Autophagy. 2023 12; 19(12):3242-3243. PMID: 37602798.
      Citations:    Fields:    Translation:Cells
    5. Tsagkaraki E, Guilherme A, Nicoloro SM, Kelly M, Lifshitz LM, Wang H, Min K, Rowland LA, Santos KB, Wetoska N, Friedline RH, Maitland SA, Chen M, Weinstein LS, Wolfe SA, Kim JK, Czech MP. Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming. Mol Metab. 2023 10; 76:101780. PMID: 37482187.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Yenilmez B, Harney S, DiMarzio C, Kelly M, Min K, Echeverria D, Bramato BM, Jackson SO, Reddig K, Kim JK, Khvorova A, Czech MP. Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice. bioRxiv. 2023 Jul 05. PMID: 37461560.
    7. Guilherme A, Rowland LA, Wetoska N, Tsagkaraki E, Santos KB, Bedard AH, Henriques F, Kelly M, Munroe S, Pedersen DJ, Ilkayeva OR, Koves TR, Tauer L, Pan M, Han X, Kim JK, Newgard CB, Muoio DM, Czech MP. Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Rep. 2023 05 30; 42(5):112488. PMID: 37163372.
      Citations:    Fields:    Translation:AnimalsCells
    8. Rowland LA, Guilherme A, Henriques F, DiMarzio C, Munroe S, Wetoska N, Kelly M, Reddig K, Hendricks G, Pan M, Han X, Ilkayeva OR, Newgard CB, Czech MP. De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics. Nat Commun. 2023 03 13; 14(1):1362. PMID: 36914626.
      Citations: 3     Fields:    Translation:Cells
    9. Yenilmez B, Kelly M, Zhang GF, Wetoska N, Ilkayeva OR, Min K, Rowland L, DiMarzio C, He W, Raymond N, Lifshitz L, Pan M, Han X, Xie J, Friedline RH, Kim JK, Gao G, Herman MA, Newgard CB, Czech MP. Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. J Biol Chem. 2022 10; 298(10):102401. PMID: 35988648.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Guilherme A, Rowland LA, Wang H, Czech MP. The adipocyte supersystem of insulin and cAMP signaling. Trends Cell Biol. 2023 04; 33(4):340-354. PMID: 35989245.
      Citations: 4     Fields:    Translation:HumansCells
    11. Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nat Commun. 2021 Nov 26; 12(1):6931. PMID: 34836963.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Yenilmez B, Wetoska N, Kelly M, Echeverria D, Min K, Lifshitz L, Alterman JF, Hassler MR, Hildebrand S, DiMarzio C, McHugh N, Vangjeli L, Sousa J, Pan M, Han X, Brehm MA, Khvorova A, Czech MP. An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis. Mol Ther. 2022 03 02; 30(3):1329-1342. PMID: 34774753.
      Citations: 7     Fields:    Translation:Animals
    13. Czech MP. Macrophage ROBOcalls rattle adipose nerves. Nat Metab. 2021 11; 3(11):1441-1442. PMID: 34782791.
      Citations:    Fields:    
    14. Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ, Czech MP, Kratky D, Rendina-Ruedy E. Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans. Bone. 2021 07; 148:115946. PMID: 33838322.
      Citations: 2     Fields:    Translation:HumansAnimals
    15. Roth J, Ashcroft FM, Wollheim CB, Kieffer TJ, Cherrington AD, Bergman RN, Taylor R, Najjar SM, Pedersen O, Ellingsgaard H, Holst JJ, Nauck MA, Kadowaki T, Czech MP, Corvera S, Saltiel AR, Corkey BE, Atkinson MA. Voices: Insulin and beyond. Cell Metab. 2021 04 06; 33(4):692-699. PMID: 33826910.
      Citations: 1     Fields:    Translation:HumansCells
    16. Luo J, Weaver MS, Fitzgibbons TP, Aouadi M, Czech MP, Allen MD. Immunotherapy for Infarcts: In Vivo Postinfarction Macrophage Modulation Using Intramyocardial Microparticle Delivery of Map4k4 Small Interfering RNA. Biores Open Access. 2020; 9(1):258-268. PMID: 33376632.
    17. Henriques F, Bedard AH, Guilherme A, Kelly M, Chi J, Zhang P, Lifshitz LM, Bellv? K, Rowland LA, Yenilmez B, Kumar S, Wang Y, Luban J, Weinstein LS, Lin JD, Cohen P, Czech MP. Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis. Cell Rep. 2020 08 04; 32(5):107998. PMID: 32755590.
      Citations: 32     Fields:    Translation:AnimalsCells
    18. Guilherme A, Yenilmez B, Bedard AH, Henriques F, Liu D, Lee A, Goldstein L, Kelly M, Nicoloro SM, Chen M, Weinstein L, Collins S, Czech MP. Control of Adipocyte Thermogenesis and Lipogenesis through ?3-Adrenergic and Thyroid Hormone Signal Integration. Cell Rep. 2020 05 05; 31(5):107598. PMID: 32375048.
      Citations: 23     Fields:    Translation:AnimalsCells
    19. Czech MP. Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab. 2020 04; 34:27-42. PMID: 32180558.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    20. Fitzgibbons TP, Lee N, Tran KV, Nicoloro S, Kelly M, Tam SK, Czech MP. Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat. JCI Insight. 2019 10 17; 4(20). PMID: 31513547.
      Citations: 11     Fields:    Translation:Humans
    21. Li Q, Nirala NK, Chen HJ, Nie Y, Wang W, Zhang B, Czech MP, Wang Q, Xu L, Mao J, Ip YT. The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium. J Cell Physiol. 2019 12; 234(12):21925-21936. PMID: 31042012.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Guilherme A, Henriques F, Bedard AH, Czech MP. Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus. Nat Rev Endocrinol. 2019 04; 15(4):207-225. PMID: 30733616.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    23. Blaszczak AM, Wright VP, Anandani K, Liu J, Jalilvand A, Bergin S, Nicoloro SM, Czech MP, Lafuse W, Deng T, Bradley D, Hsueh WA. Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism. J Immunol. 2019 04 15; 202(8):2451-2459. PMID: 30850480.
      Citations: 6     Fields:    Translation:AnimalsCells
    24. Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP. CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. J Biol Chem. 2018 11 02; 293(44):17291-17305. PMID: 30190322.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    25. Guilherme A, Pedersen DJ, Henriques F, Bedard AH, Henchey E, Kelly M, Morgan DA, Rahmouni K, Czech MP. Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. Mol Metab. 2018 10; 16:116-125. PMID: 30005879.
      Citations: 22     Fields:    Translation:AnimalsCells
    26. Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Bl?her M, Czech MP, Tabas I. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018 03 29; 555(7698):673-677. PMID: 29562231.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    27. Czech MP. Macrophages dispose of catecholamines in adipose tissue. Nat Med. 2017 11 07; 23(11):1255-1257. PMID: 29117176.
      Citations: 9     Fields:    Translation:HumansCells
    28. Jourdan T, Nicoloro SM, Zhou Z, Shen Y, Liu J, Coffey NJ, Cinar R, Godlewski G, Gao B, Aouadi M, Czech MP, Kunos G. Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice. Mol Metab. 2017 11; 6(11):1517-1528. PMID: 29107297.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Czech MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017 Jul 11; 23(7):804-814. PMID: 28697184.
      Citations: 463     Fields:    Translation:HumansCells
    30. Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE, Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia. Cardiovasc Diabetol. 2017 07 07; 16(1):87. PMID: 28687077.
      Citations: 8     Fields:    Translation:Humans
    31. Roth Flach RJ, DiStefano MT, Danai LV, Senol-Cosar O, Yawe JC, Kelly M, Garcia Menendez L, Czech MP. Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity. Am J Physiol Endocrinol Metab. 2017 09 01; 313(3):E303-E313. PMID: 28611026.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP. Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming. Mol Metab. 2017 08; 6(8):781-796. PMID: 28752043.
      Citations: 35     Fields:    Translation:AnimalsCells
    33. Jourdan T, Szanda G, Cinar R, Godlewski G, Holovac DJ, Park JK, Nicoloro S, Shen Y, Liu J, Rosenberg AZ, Liu Z, Czech MP, Kunos G. Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes. Diabetes. 2017 04; 66(4):994-1007. PMID: 28082458.
      Citations: 22     Fields:    Translation:AnimalsCells
    34. DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP. Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance. Mol Metab. 2016 12; 5(12):1149-1161. PMID: 27900258.
      Citations: 16     Fields:    Translation:AnimalsCells
    35. Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP. Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function. Mol Cell Biol. 2016 06 15; 36(12):1740-9. PMID: 27044870.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    36. Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem. 2016 07 29; 291(31):16221-30. PMID: 27226575.
      Citations: 12     Fields:    Translation:AnimalsCells
    37. Virbasius JV, Czech MP. Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases. Trends Endocrinol Metab. 2016 07; 27(7):484-492. PMID: 27160798.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    38. Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S. Activation of mTORC1 is essential for ?-adrenergic stimulation of adipose browning. J Clin Invest. 2016 05 02; 126(5):1704-16. PMID: 27018708.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    39. Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP. Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. Nat Commun. 2016 Feb 16; 7:10686. PMID: 26880110.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    40. Cohen JL, Shen Y, Aouadi M, Vangala P, Tencerova M, Amano SU, Nicoloro SM, Yawe JC, Czech MP. Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA. Mol Pharm. 2016 Mar 07; 13(3):964-978. PMID: 26815386.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    41. Fitzgibbons TP, Czech MP. Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance. J Mol Med (Berl). 2016 Mar; 94(3):267-75. PMID: 26847458.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    42. Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21; 6:8995. PMID: 26688060.
      Citations: 44     Fields:    Translation:AnimalsCells
    43. Roth Flach RJ, Czech MP. NETs and traps delay wound healing in diabetes. Trends Endocrinol Metab. 2015 Sep; 26(9):451-2. PMID: 26239304.
      Citations: 14     Fields:    Translation:HumansCells
    44. Danai LV, Flach RJ, Virbasius JV, Menendez LG, Jung DY, Kim JH, Kim JK, Czech MP. Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues. Mol Cell Biol. 2015 Jul; 35(13):2356-65. PMID: 25918248.
      Citations: 20     Fields:    Translation:Animals
    45. Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP. A major role of insulin in promoting obesity-associated adipose tissue inflammation. Mol Metab. 2015 Jul; 4(7):507-18. PMID: 26137438.
      Citations: 59     Fields:    
    46. DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP. The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis. J Biol Chem. 2015 Jun 12; 290(24):15175-84. PMID: 25922078.
      Citations: 24     Fields:    Translation:AnimalsCells
    47. Tencerova M, Aouadi M, Vangala P, Nicoloro SM, Yawe JC, Cohen JL, Shen Y, Garcia-Menendez L, Pedersen DJ, Gallagher-Dorval K, Perugini RA, Gupta OT, Czech MP. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 2015 Jul; 29(7):2959-69. PMID: 25805830.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    48. Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014 Nov 10; 31(3):291-304. PMID: 25453828.
      Citations: 89     Fields:    Translation:AnimalsCells
    49. Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PLoS One. 2014; 9(9):e107265. PMID: 25216251.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    50. Aouadi M, Vangala P, Yawe JC, Tencerova M, Nicoloro SM, Cohen JL, Shen Y, Czech MP. Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance. Am J Physiol Endocrinol Metab. 2014 Aug 15; 307(4):E374-83. PMID: 24986598.
      Citations: 42     Fields:    Translation:AnimalsCells
    51. Sun K, Park J, Gupta OT, Holland WL, Auerbach P, Zhang N, Goncalves Marangoni R, Nicoloro SM, Czech MP, Varga J, Ploug T, An Z, Scherer PE. Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nat Commun. 2014 Mar 19; 5:3485. PMID: 24647224.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    52. Fitzgibbons TP, Czech MP. Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. J Am Heart Assoc. 2014 Mar 04; 3(2):e000582. PMID: 24595191.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    53. Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M. Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab. 2014 Jan 07; 19(1):162-171. PMID: 24374218.
      Citations: 296     Fields:    Translation:HumansAnimalsCells
    54. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med. 2013 Sep; 19(9):1132-40. PMID: 23955712.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    55. Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP. Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res. 2013 Oct; 54(10):2697-707. PMID: 23924694.
      Citations: 19     Fields:    Translation:AnimalsCells
    56. Czech MP. Obesity Notches up fatty liver. Nat Med. 2013 Aug; 19(8):969-71. PMID: 23921741.
      Citations: 9     Fields:    Translation:HumansAnimals
    57. Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP. Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8278-83. PMID: 23630254.
      Citations: 67     Fields:    Translation:AnimalsCells
    58. Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013 May 01; 304(9):E951-63. PMID: 23482447.
      Citations: 31     Fields:    Translation:AnimalsCells
    59. Czech MP, Tencerova M, Pedersen DJ, Aouadi M. Insulin signalling mechanisms for triacylglycerol storage. Diabetologia. 2013 May; 56(5):949-64. PMID: 23443243.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    60. Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. ?3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation. J Biol Chem. 2013 Jan 25; 288(4):2882-92. PMID: 23235150.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    61. Wang M, Amano SU, Flach RJ, Chawla A, Aouadi M, Czech MP. Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol Cell Biol. 2013 Feb; 33(4):678-87. PMID: 23207904.
      Citations: 23     Fields:    Translation:AnimalsCells
    62. Sartorius T, Staiger H, Ketterer C, Heni M, Machicao F, Guilherme A, Grallert H, Schulze MB, Boeing H, Stefan N, Fritsche A, Czech MP, H?ring HU. Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans. PLoS One. 2012; 7(10):e47647. PMID: 23094072.
      Citations: 15     Fields:    Translation:HumansCells
    63. Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2):81-7. PMID: 22327367.
      Citations: 194     Fields:    Translation:Humans
    64. Young JL, Mora A, Cerny A, Czech MP, Woda B, Kurt-Jones EA, Finberg RW, Corvera S. CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone. PLoS One. 2012; 7(1):e29688. PMID: 22253759.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    65. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Kr?ger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 07; 14(3):378-89. PMID: 21907143.
      Citations: 28     Fields:    Translation:AnimalsCells
    66. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1425-37. PMID: 21765057.
      Citations: 155     Fields:    Translation:AnimalsCells
    67. Corvera S, Czech MP. Tensions rise and blood flows over dysfunctional fat. Circulation. 2011 Jul 05; 124(1):13-6. PMID: 21730320.
      Citations: 3     Fields:    Translation:HumansCells
    68. Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ, Soto E, Ostroff GR, Czech MP. Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J. 2011 Jun 01; 436(2):351-62. PMID: 21418037.
      Citations: 40     Fields:    Translation:AnimalsCells
    69. Mudhasani R, Puri V, Hoover K, Czech MP, Imbalzano AN, Jones SN. Dicer is required for the formation of white but not brown adipose tissue. J Cell Physiol. 2011 May; 226(5):1399-406. PMID: 20945399.
      Citations: 34     Fields:    Translation:AnimalsCells
    70. Czech MP, Aouadi M, Tesz GJ. RNAi-based therapeutic strategies for metabolic disease. Nat Rev Endocrinol. 2011 Apr 19; 7(8):473-84. PMID: 21502982.
      Citations: 41     Fields:    Translation:HumansAnimals
    71. Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature. 2011 Feb 17; 470(7334):414-8. PMID: 21331046.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    72. Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, Tran KV, Straubhaar J, Nicoloro S, Czech MP, Thompson M, Perugini RA, Corvera S. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation. 2011 Jan 18; 123(2):186-94. PMID: 21200001.
      Citations: 155     Fields:    Translation:Humans
    73. Ranjit S, Boutet E, Gandhi P, Prot M, Tamori Y, Chawla A, Greenberg AS, Puri V, Czech MP. Regulation of fat specific protein 27 by isoproterenol and TNF-a to control lipolysis in murine adipocytes. J Lipid Res. 2011 Feb; 52(2):221-36. PMID: 21097823.
      Citations: 34     Fields:    Translation:AnimalsCells
    74. Christianson JL, Boutet E, Puri V, Chawla A, Czech MP. Identification of the lipid droplet targeting domain of the Cidea protein. J Lipid Res. 2010 Dec; 51(12):3455-62. PMID: 20810722.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    75. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 03; 285(36):27581-9. PMID: 20587420.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    76. Hardy OT, Perugini RA, Nicoloro SM, Gallagher-Dorval K, Puri V, Straubhaar J, Czech MP. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis. 2011 Jan-Feb; 7(1):60-7. PMID: 20678967.
      Citations: 107     Fields:    Translation:HumansCells
    77. Guntur KV, Guilherme A, Xue L, Chawla A, Czech MP. Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem. 2010 Feb 26; 285(9):6595-603. PMID: 20038583.
      Citations: 19     Fields:    Translation:AnimalsCells
    78. Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magr? J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S, Savage DB. Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med. 2009 Aug; 1(5):280-7. PMID: 20049731.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    79. Marchand P, Antoine M, Le Baut G, Czech M, Baasner S, G?nther E. Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents. Bioorg Med Chem. 2009 Sep 15; 17(18):6715-27. PMID: 19682911.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    80. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009 Apr 30; 458(7242):1180-4. PMID: 19407801.
      Citations: 230     Fields:    Translation:AnimalsCells
    81. Guilherme A, Tesz GJ, Guntur KVP, Czech MP. Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem. 2009 Jun 19; 284(25):17082-17091. PMID: 19321447.
      Citations: 23     Fields:    Translation:AnimalsCells
    82. Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, Tissenbaum HA. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009 Mar 06; 136(5):939-51. PMID: 19249087.
      Citations: 95     Fields:    Translation:AnimalsCells
    83. Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE. Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol. 2009; 256(1-2):86-91. PMID: 19230866.
      Citations: 11     Fields:    Translation:AnimalsCells
    84. Antoine M, Marchand P, Le Baut G, Czech M, Baasner S, Gunther E. Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents. J Enzyme Inhib Med Chem. 2008 Oct; 23(5):686-95. PMID: 18821257.
      Citations: 2     Fields:    Translation:HumansCells
    85. Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S. Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem. 2008 Nov 07; 283(45):30658-67. PMID: 18779333.
      Citations: 30     Fields:    Translation:AnimalsCells
    86. Puri V, Czech MP. Lipid droplets: FSP27 knockout enhances their sizzle. J Clin Invest. 2008 Aug; 118(8):2693-6. PMID: 18654644.
      Citations: 28     Fields:    Translation:AnimalsCells
    87. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7833-8. PMID: 18509062.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    88. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 01; 411(3):647-55. PMID: 18215134.
      Citations: 19     Fields:    Translation:AnimalsCells
    89. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008 May; 9(5):367-77. PMID: 18401346.
      Citations: 917     Fields:    Translation:HumansAnimalsCells
    90. Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 2008 Jul; 28(13):4215-26. PMID: 18426911.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    91. Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol. 2008 Apr; 28(7):2187-200. PMID: 18195045.
      Citations: 45     Fields:    Translation:AnimalsCells
    92. DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007 Nov 30; 28(4):569-83. PMID: 18042453.
      Citations: 90     Fields:    Translation:AnimalsCells
    93. Christianson JL, Nicoloro S, Straubhaar J, Czech MP. Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. J Biol Chem. 2008 Feb 01; 283(5):2906-16. PMID: 18032385.
      Citations: 41     Fields:    Translation:AnimalsCells
    94. Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, Chakladar A, Czech MP. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem. 2007 Nov 23; 282(47):34213-8. PMID: 17884815.
      Citations: 152     Fields:    Translation:AnimalsCells
    95. Saito T, Jones CC, Huang S, Czech MP, Pilch PF. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem. 2007 Nov 02; 282(44):32280-7. PMID: 17848569.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    96. Tesz GJ, Guilherme A, Guntur KV, Hubbard AC, Tang X, Chawla A, Czech MP. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem. 2007 Jul 06; 282(27):19302-12. PMID: 17500068.
      Citations: 45     Fields:    Translation:AnimalsCells
    97. Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab. 2007 Apr; 5(4):237-52. PMID: 17403369.
      Citations: 478     Fields:    Translation:HumansAnimalsCells
    98. Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP. Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol. 2007 May; 27(9):3456-69. PMID: 17339344.
      Citations: 44     Fields:    Translation:AnimalsCells
    99. Puri V, Chakladar A, Virbasius JV, Konda S, Powelka AM, Chouinard M, Hagan GN, Perugini R, Czech MP. RNAi-based gene silencing in primary mouse and human adipose tissues. J Lipid Res. 2007 Feb; 48(2):465-71. PMID: 17093294.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    100. Czech MP. MicroRNAs as therapeutic targets. N Engl J Med. 2006 Mar 16; 354(11):1194-5. PMID: 16540623.
      Citations: 40     Fields:    Translation:Animals
    101. Tang X, Guilherme A, Chakladar A, Powelka AM, Konda S, Virbasius JV, Nicoloro SM, Straubhaar J, Czech MP. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2087-92. PMID: 16461467.
      Citations: 79     Fields:    Translation:AnimalsCells
    102. Czech MP. ARNT misbehavin' in diabetic beta cells. Nat Med. 2006 Jan; 12(1):39-40. PMID: 16397560.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    103. Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J Clin Invest. 2006 Jan; 116(1):125-36. PMID: 16374519.
      Citations: 106     Fields:    Translation:AnimalsCells
    104. Liu L, Song X, He D, Komma C, Kita A, Virbasius JV, Huang G, Bellamy HD, Miki K, Czech MP, Zhou GW. Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. J Biol Chem. 2006 Feb 17; 281(7):4254-60. PMID: 16338929.
      Citations: 10     Fields:    Translation:AnimalsCells
    105. Bose A, Guilherme A, Huang S, Hubbard AC, Lane CR, Soriano NA, Czech MP. The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes. J Biol Chem. 2005 Nov 04; 280(44):36946-51. PMID: 16131485.
      Citations: 23     Fields:    Translation:AnimalsCells
    106. Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem. 2005 Jun 10; 280(23):22523-9. PMID: 15824124.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    107. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 03; 280(22):21622-8. PMID: 15799971.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    108. Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J Immunol. 2004 Dec 15; 173(12):7331-8. PMID: 15585857.
      Citations: 60     Fields:    Translation:AnimalsCells
    109. Mello CC, Czech MP. Micromanaging insulin secretion. Nat Med. 2004 Dec; 10(12):1297-8. PMID: 15580250.
      Citations: 12     Fields:    Translation:Humans
    110. Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, Straubhaar J, Czech MP, Corvera S. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest. 2004 Nov; 114(9):1281-9. PMID: 15520860.
      Citations: 283     Fields:    Translation:AnimalsCells
    111. Huang S, Lifshitz L, Patki-Kamath V, Tuft R, Fogarty K, Czech MP. Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol. 2004 Oct; 24(20):9102-23. PMID: 15456883.
      Citations: 41     Fields:    Translation:AnimalsCells
    112. Cronin TC, DiNitto JP, Czech MP, Lambright DG. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J. 2004 Oct 01; 23(19):3711-20. PMID: 15359279.
      Citations: 61     Fields:    Translation:HumansCells
    113. Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 2004 Aug 15; 18(16):1976-80. PMID: 15314024.
      Citations: 49     Fields:    Translation:AnimalsCells
    114. Mitra P, Zheng X, Czech MP. RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. J Biol Chem. 2004 Sep 03; 279(36):37431-5. PMID: 15258163.
      Citations: 26     Fields:    Translation:AnimalsCells
    115. Guilherme A, Soriano NA, Furcinitti PS, Czech MP. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem. 2004 Sep 17; 279(38):40062-75. PMID: 15247266.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    116. Bose A, Robida S, Furcinitti PS, Chawla A, Fogarty K, Corvera S, Czech MP. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol. 2004 Jun; 24(12):5447-58. PMID: 15169906.
      Citations: 83     Fields:    Translation:AnimalsCells
    117. Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12; 279(11):10593-605. PMID: 14676205.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    118. Czech MP. Insulin's expanding control of forkheads. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11198-200. PMID: 14506300.
      Citations: 12     Fields:    Translation:Animals
    119. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74. PMID: 12808134.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    120. Semiz S, Park JG, Nicoloro SM, Furcinitti P, Zhang C, Chawla A, Leszyk J, Czech MP. Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J. 2003 May 15; 22(10):2387-99. PMID: 12743033.
      Citations: 67     Fields:    Translation:AnimalsCells
    121. Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol. 2003 Feb; 23(3):1085-94. PMID: 12529412.
      Citations: 194     Fields:    Translation:AnimalsCells
    122. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4. PMID: 12490950.
      Citations: 122     Fields:    Translation:AnimalsCells
    123. Czech MP. Dynamics of phosphoinositides in membrane retrieval and insertion. Annu Rev Physiol. 2003; 65:791-815. PMID: 12518000.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    124. Czech MP. Fat targets for insulin signaling. Mol Cell. 2002 Apr; 9(4):695-6. PMID: 11983159.
      Citations: 7     Fields:    Translation:HumansCells
    125. Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J Biol Chem. 2002 Jan 04; 277(1):509-15. PMID: 11694514.
      Citations: 58     Fields:    Translation:Humans
    126. Czech MP. PIP2 and PIP3: complex roles at the cell surface. Cell. 2000 Mar 17; 100(6):603-6. PMID: 10761925.
      Citations: 209     Fields:    Translation:Animals
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