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Thomas C Greenough MD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-6282
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - School of Medicine
    DepartmentPediatrics
    DivisionPediatric Immunology & Infectious Diseases


    Collapse Biography 
    Collapse education and training
    Amherst College, Amherst, MA, United StatesBABiology
    University of Rochester School of Medicine, Rochester, NY, United StatesMD

    Collapse Overview 
    Collapse overview

    Education


    Amherst College                                                                           B.A.         1981      Biology


    University of Rochester School of Medicine and Dentistry           M.D.        1987      Medicine


    Post-Graduate Training


    1987-1990           Internal Medicine Residency, University Hospital, Boston Univ. School of Medicine


    1990-1993           Infectious Diseases Fellowship, University of Massachusetts Medical Center


    Board Certification


    1990      Internal Medicine,  American Board of Internal Medicine


    1992      Infectious Diseases,  American Board of Internal Medicine


    Health Care System and UMMS Appointments:


    Associate Professor of Medicine, University of Massachusetts Medical School


    2000-present    Member, UMMS Institutional Biosafety Committee


    2004-present    Chair, UMMS Institutional Biosafety Committee


    Honors



    • 1996      Greater Lawrence Family Health Center Award.  “In recognition of dedication to care of HIV infected people in the Merrimack Valley”

    • 2009      Merrimack Valley Area Health Education Center & Greater Lawrence Family Health Center Award.  For “years of dedicated services in the field of HIV Care”

    • 2013      Sister Willie Leadership Award.  For “dedication, compassion & commitment to enhance the lives of those infected and affected by HIV/AIDS”.  Lowell World AIDS Day Committee


    Research Interests



    • HIV pathogenesis

    • Viral immunology and vaccine development

    • SARS associated coronavirus

    • Epstein Barr Virus


    Clinical Focus



    • Comprehensive care for HIV-infected adults.  

    • Specialty care of individuals with hepatitis C virus and other infectious diseases.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Brumme Z, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth. AIDS. 2018 Oct 15. PMID: 30325763.
      View in: PubMed
    2. Chancellor JR, Padmanabhan SP, Greenough TC, Sacra R, Ellison RT, Madoff LC, Droms RJ, Hinkle DM, Asdourian GK, Finberg RW, Stroher U, Uyeki TM, Cerón OM. Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease. Emerg Infect Dis. 2016 Feb; 22(2):295-7. PMID: 26812218.
      View in: PubMed
    3. Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, Lambrecht LK, Somasundaran M, Luzuriaga KF. A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol. 2015 Nov 01; 195(9):4185-97. PMID: 26416268.
      View in: PubMed
    4. Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids. J Virol. 2014 Apr; 88(7):3744-55. PMID: 24429365.
      View in: PubMed
    5. Alpert MD, Heyer LN, Williams DE, Harvey JD, Greenough T, Allhorn M, Evans DT. A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays. J Virol. 2012 Nov; 86(22):12039-52. PMID: 22933282.
      View in: PubMed
    6. Persaud D, Luzuriaga K, Ziemniak C, Muresan P, Greenough T, Fenton T, Blackford A, Ferguson K, Neu N, Cunningham CK. Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir. AIDS. 2011 Nov 28; 25(18):2227-34. PMID: 21918423.
      View in: PubMed
    7. Friberg H, Bashyam H, Toyosaki-Maeda T, Potts JA, Greenough T, Kalayanarooj S, Gibbons RV, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Rothman AL, Mathew A. Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Sci Rep. 2011; 1:51. PMID: 22355570.
      View in: PubMed
    8. Sharkey M, Babic DZ, Greenough T, Gulick R, Kuritzkes DR, Stevenson M. Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure. PLoS Pathog. 2011 Feb; 7(2):e1001303. PMID: 21383975.
      View in: PubMed
    9. Greenough TC, Campellone SC, Brody R, Jain S, Sanchez-Merino V, Somasundaran M, Luzuriaga K. Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage. PLoS One. 2010 Sep 23; 5(9):e12926. PMID: 20886079.
      View in: PubMed
    10. Shiu C, Cunningham CK, Greenough T, Muresan P, Sanchez-Merino V, Carey V, Jackson JB, Ziemniak C, Fox L, Belzer M, Ray SC, Luzuriaga K, Persaud D. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J Virol. 2009 Oct; 83(19):9731-42. PMID: 19605490.
      View in: PubMed
    11. Greenough TC, Cunningham CK, Muresan P, McManus M, Persaud D, Fenton T, Barker P, Gaur A, Panicali D, Sullivan JL, Luzuriaga K. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine. 2008 Dec 09; 26(52):6883-93. PMID: 18940219.
      View in: PubMed
    12. Swingler S, Zhou J, Swingler C, Dauphin A, Greenough T, Jolicoeur P, Stevenson M. Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe. 2008 Jul 17; 4(1):63-76. PMID: 18621011.
      View in: PubMed
    13. Haupt S, Donhauser N, Chaipan C, Schuster P, Puffer B, Daniels RS, Greenough TC, Kirchhoff F, Schmidt B. CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells. J Virol. 2008 Sep; 82(17):8900-5. PMID: 18579609.
      View in: PubMed
    14. Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood. 2008 Feb 1; 111(3):1420-7. PMID: 17991806.
      View in: PubMed
    15. Roberts A, Thomas WD, Guarner J, Lamirande EW, Babcock GJ, Greenough TC, Vogel L, Hayes N, Sullivan JL, Zaki S, Subbarao K, Ambrosino DM. Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters. J Infect Dis. 2006 Mar 1; 193(5):685-92. PMID: 16453264.
      View in: PubMed
    16. Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, Jones LP, Yilla M, Babcock GJ, Greenough T, Ambrosino DM, Alvarez R, Callaway J, Cavitt S, Kamrud K, Alterson H, Smith J, Harcourt JL, Miao C, Razdan R, Comer JA, Rollin PE, Ksiazek TG, Sanchez A, Rota PA, Bellini WJ, Anderson LJ. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. J Virol Methods. 2005 Sep; 128(1-2):21-8. PMID: 15885812.
      View in: PubMed
    17. Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005 Aug; 167(2):455-63. PMID: 16049331.
      View in: PubMed
    18. Farrow MA, Somasundaran M, Zhang C, Gabuzda D, Sullivan JL, Greenough TC. Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses. 2005 Jun; 21(6):565-74. PMID: 15989462.
      View in: PubMed
    19. Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD, Coccia JA, Graziano RF, Srinivasan M, Lowy I, Finberg RW, Subbarao K, Vogel L, Somasundaran M, Luzuriaga K, Sullivan JL, Ambrosino DM. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J Infect Dis. 2005 Feb 15; 191(4):507-14. PMID: 15655773.
      View in: PubMed
    20. Moore MJ, Dorfman T, Li W, Wong SK, Li Y, Kuhn JH, Coderre J, Vasilieva N, Han Z, Greenough TC, Farzan M, Choe H. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(19):10628-35. PMID: 15367630.
      View in: PubMed
    21. Li W, Greenough TC, Moore MJ, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H. Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(20):11429-33. PMID: 15452268.
      View in: PubMed
    22. Hiebenthal-Millow K, Greenough TC, Bretttler DB, Schindler M, Wildum S, Sullivan JL, Kirchhoff F. Alterations in HIV-1 LTR promoter activity during AIDS progression. Virology. 2003 Dec 5; 317(1):109-18. PMID: 14675629.
      View in: PubMed
    23. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov 27; 426(6965):450-4. PMID: 14647384.
      View in: PubMed
    24. Schindler M, Würfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, Münch J, Kirchhoff F. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol. 2003 Oct; 77(19):10548-56. PMID: 12970439.
      View in: PubMed
    25. Haran JP, Greenough TC, Luzuriaga K, Sullivan JL, Flanigan T, Somasundaran M. Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2002 May 20; 18(8):577-83. PMID: 12036487.
      View in: PubMed
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