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Thomas C Greenough MD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-441-8230
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases

    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    Amherst College, Amherst, MA, United StatesBABiology
    University of Rochester School of Medicine, Rochester, NY, United StatesMD

    Collapse Overview 
    Collapse overview

    Education


    Amherst College                                                                           B.A.         1981      Biology


    University of Rochester School of Medicine and Dentistry           M.D.        1987      Medicine


    Post-Graduate Training


    1987-1990           Internal Medicine Residency, University Hospital, Boston Univ. School of Medicine


    1990-1993           Infectious Diseases Fellowship, University of Massachusetts Medical Center


    Board Certification


    1990      Internal Medicine,  American Board of Internal Medicine


    1992      Infectious Diseases,  American Board of Internal Medicine


    Health Care System and UMMS Appointments:


    Associate Professor of Medicine, University of Massachusetts Medical School


    2000-present    Member, UMMS Institutional Biosafety Committee


    2004-present    Chair, UMMS Institutional Biosafety Committee


    Honors



    • 1996      Greater Lawrence Family Health Center Award.  “In recognition of dedication to care of HIV infected people in the Merrimack Valley”

    • 2009      Merrimack Valley Area Health Education Center & Greater Lawrence Family Health Center Award.  For “years of dedicated services in the field of HIV Care”

    • 2013      Sister Willie Leadership Award.  For “dedication, compassion & commitment to enhance the lives of those infected and affected by HIV/AIDS”.  Lowell World AIDS Day Committee


    Research Interests



    • HIV pathogenesis

    • Viral immunology and vaccine development

    • SARS associated coronavirus

    • Epstein Barr Virus


    Clinical Focus



    • Comprehensive care for HIV-infected adults.  

    • Specialty care of individuals with hepatitis C virus and other infectious diseases.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kurt-Jones EA, Dudek TE, Watanabe D, Mandell L, Che J, Zhou S, Cao L, Greenough T, Babcock GJ, Diaz F, Oh HS, Zhou C, Finberg RW, Knipe DM. Expression of SARS coronavirus 1 spike protein from a herpesviral vector induces innate immune signaling and neutralizing antibody responses. Virology. 2021 07; 559:165-172. PMID: 33930819.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    2. Theodoropoulos NM, Bolstorff B, Bozorgzadeh A, Brandeburg C, Cumming M, Daly JS, Ellison RT, Forsberg K, Gade L, Gibson L, Greenough T, Litvintseva AP, Mack DA, Madoff L, Martins PN, McHale E, Melvin Z, Movahedi B, Stiles T, Vallabhaneni S, Levitz SM. Candida auris outbreak involving liver transplant recipients in a surgical intensive care unit. Am J Transplant. 2020 12; 20(12):3673-3679. PMID: 32530145.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    3. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020 03; 21(3):274-286. PMID: 32066947.
      Citations: 43     Fields:    Translation:HumansCells
    4. Brumme ZL, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth. AIDS. 2019 02 01; 33(2):211-218. PMID: 30325763.
      Citations: 10     Fields:    Translation:HumansCells
    5. Chancellor JR, Padmanabhan SP, Greenough TC, Sacra R, Ellison RT, Madoff LC, Droms RJ, Hinkle DM, Asdourian GK, Finberg RW, Stroher U, Uyeki TM, Cer?n OM. Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease. Emerg Infect Dis. 2016 Feb; 22(2):295-7. PMID: 26812218.
      Citations: 17     Fields:    Translation:HumansCells
    6. Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, Lambrecht LK, Somasundaran M, Luzuriaga KF. A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol. 2015 Nov 01; 195(9):4185-97. PMID: 26416268.
      Citations: 16     Fields:    Translation:HumansCells
    7. Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids. J Virol. 2014 Apr; 88(7):3744-55. PMID: 24429365.
      Citations: 11     Fields:    Translation:HumansCells
    8. Alpert MD, Heyer LN, Williams DE, Harvey JD, Greenough T, Allhorn M, Evans DT. A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays. J Virol. 2012 Nov; 86(22):12039-52. PMID: 22933282.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    9. Persaud D, Luzuriaga K, Ziemniak C, Muresan P, Greenough T, Fenton T, Blackford A, Ferguson K, Neu N, Cunningham CK. Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir. AIDS. 2011 Nov 28; 25(18):2227-34. PMID: 21918423.
      Citations: 22     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    10. Friberg H, Bashyam H, Toyosaki-Maeda T, Potts JA, Greenough T, Kalayanarooj S, Gibbons RV, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Rothman AL, Mathew A. Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Sci Rep. 2011; 1:51. PMID: 22355570.
      Citations: 47     Fields:    Translation:HumansCells
    11. Sharkey M, Babic DZ, Greenough T, Gulick R, Kuritzkes DR, Stevenson M. Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure. PLoS Pathog. 2011 Feb; 7(2):e1001303. PMID: 21383975.
      Citations: 46     Fields:    Translation:HumansCells
    12. Greenough TC, Campellone SC, Brody R, Jain S, Sanchez-Merino V, Somasundaran M, Luzuriaga K. Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage. PLoS One. 2010 Sep 23; 5(9):e12926. PMID: 20886079.
      Citations: 15     Fields:    Translation:HumansCells
    13. Shiu C, Cunningham CK, Greenough T, Muresan P, Sanchez-Merino V, Carey V, Jackson JB, Ziemniak C, Fox L, Belzer M, Ray SC, Luzuriaga K, Persaud D. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J Virol. 2009 Oct; 83(19):9731-42. PMID: 19605490.
      Citations: 31     Fields:    Translation:HumansCellsPHPublic Health
    14. Greenough TC, Cunningham CK, Muresan P, McManus M, Persaud D, Fenton T, Barker P, Gaur A, Panicali D, Sullivan JL, Luzuriaga K. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine. 2008 Dec 09; 26(52):6883-93. PMID: 18940219.
      Citations: 20     Fields:    Translation:HumansCellsCTClinical Trials
    15. Swingler S, Zhou J, Swingler C, Dauphin A, Greenough T, Jolicoeur P, Stevenson M. Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe. 2008 Jul 17; 4(1):63-76. PMID: 18621011.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    16. Haupt S, Donhauser N, Chaipan C, Schuster P, Puffer B, Daniels RS, Greenough TC, Kirchhoff F, Schmidt B. CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells. J Virol. 2008 Sep; 82(17):8900-5. PMID: 18579609.
      Citations: 13     Fields:    Translation:HumansCells
    17. Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood. 2008 Feb 01; 111(3):1420-7. PMID: 17991806.
      Citations: 49     Fields:    Translation:Cells
    18. Roberts A, Thomas WD, Guarner J, Lamirande EW, Babcock GJ, Greenough TC, Vogel L, Hayes N, Sullivan JL, Zaki S, Subbarao K, Ambrosino DM. Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters. J Infect Dis. 2006 Mar 01; 193(5):685-92. PMID: 16453264.
      Citations: 60     Fields:    Translation:AnimalsCells
    19. Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, Jones LP, Yilla M, Babcock GJ, Greenough T, Ambrosino DM, Alvarez R, Callaway J, Cavitt S, Kamrud K, Alterson H, Smith J, Harcourt JL, Miao C, Razdan R, Comer JA, Rollin PE, Ksiazek TG, Sanchez A, Rota PA, Bellini WJ, Anderson LJ. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. J Virol Methods. 2005 Sep; 128(1-2):21-8. PMID: 15885812.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    20. Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005 Aug; 167(2):455-63. PMID: 16049331.
      Citations: 70     Fields:    Translation:AnimalsCells
    21. Farrow MA, Somasundaran M, Zhang C, Gabuzda D, Sullivan JL, Greenough TC. Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses. 2005 Jun; 21(6):565-74. PMID: 15989462.
      Citations: 13     Fields:    Translation:HumansCells
    22. Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD, Coccia JA, Graziano RF, Srinivasan M, Lowy I, Finberg RW, Subbarao K, Vogel L, Somasundaran M, Luzuriaga K, Sullivan JL, Ambrosino DM. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J Infect Dis. 2005 Feb 15; 191(4):507-14. PMID: 15655773.
      Citations: 90     Fields:    Translation:AnimalsCells
    23. Moore MJ, Dorfman T, Li W, Wong SK, Li Y, Kuhn JH, Coderre J, Vasilieva N, Han Z, Greenough TC, Farzan M, Choe H. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(19):10628-35. PMID: 15367630.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    24. Li W, Greenough TC, Moore MJ, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H. Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(20):11429-33. PMID: 15452268.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    25. Hiebenthal-Millow K, Greenough TC, Bretttler DB, Schindler M, Wildum S, Sullivan JL, Kirchhoff F. Alterations in HIV-1 LTR promoter activity during AIDS progression. Virology. 2003 Dec 05; 317(1):109-18. PMID: 14675629.
      Citations: 11     Fields:    Translation:HumansCells
    26. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov 27; 426(6965):450-4. PMID: 14647384.
      Citations: 3247     Fields:    Translation:HumansAnimalsCells
    27. Schindler M, W?rfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, M?nch J, Kirchhoff F. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol. 2003 Oct; 77(19):10548-56. PMID: 12970439.
      Citations: 101     Fields:    Translation:HumansCells
    28. Haran JP, Greenough TC, Luzuriaga K, Sullivan JL, Flanigan T, Somasundaran M. Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2002 May 20; 18(8):577-83. PMID: 12036487.
      Citations: 1     Fields:    Translation:HumansCells
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