Header Logo

Michael Richard Green MD, PhD

TitleChair and Professor
Endowed TitleLambi and Sarah Adams Chair in Genetic Research
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB-628
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBioinformatics and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology

    Collapse Biography 
    Collapse education and training
    University of Wisconsin, Madison, Madison, WI, United StatesBSBiochemistry
    Washington University in St Louis, Saint Louis, MO, United StatesMD
    Washington University in St Louis, Saint Louis, MO, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse overview

    Brief Biography

    Michael Green received his MD and PhD degrees from Washington University School of Medicine in 1981. He carried out postdoctoral work at Harvard University, where he joined as a faculty member in 1984. In 1990, he joined the Program in Molecular Medicine at the University of Massachusetts Medical School (UMMS), and in 1999 became the Director of the Program of Gene Function and Expression (PGFE). In 2014, PGFE merged with the Department of Cancer Biology, and Dr. Green was appointed as Chair of the new Department of Molecular, Cell and Cancer Biology (MCCB). In addition to his role as Chair of MCCB, he is also Vice Provost of Strategic Research Initiatives, Director of the Cancer Center, and Co-Director of The Li Weibo Institute for Rare Diseases Research.

    Dr. Green has made pioneering contributions to our understanding of the mechanisms that regulate gene expression in eukaryotes and how alterations in gene expression contribute to cancer and other human diseases. He is an elected member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the European Molecular Biology Organization.

    Discovery of Therapeutically Targetable Pathways in Cancer and Other Diseases

    Identification of New Factors and Regulatory Pathways that Promote or Prevent Cancer

    My laboratory has used transcription-based approaches, functional screens (such as genome-wide loss-of-function RNAi- and CRISPR-based screens) and genomic methods to identify new genes and regulatory pathways that contribute to cancer. These studies are intended to enhance our understanding of the molecular basis of cancer and reveal potential new targets for therapeutic intervention. These approaches have enabled us to discover new oncogenes, such as the H2A ubiquitin ligase TRIM37 (Bhatnagar et al. 2014), tumor suppressor genes, such as the CREB coactivator CRTC2 (Fang et al. 2015) and repressors of FGFR signaling (Lin et al. 2014), and metastasis suppressor genes, such as GAS1 (Gobeil et al. 2008) and the histone H3K9 demethylase KDM3A (Pedanou et al. 2016). We have also identified two therapeutically targetable mechanisms that render chronic myeloid leukemia (CML) stem cells resistant to the drug imatinib mesylate (also known as Gleevec), the first-line treatment for CML (Ma et al. 2014; Ma et al. 2019). We are currently conducting functional screens to identify new factors involved in various aspects of cancer biology including transformation, cancer stem cell formation and maintenance, regulation of the epithelial-to-mesenchymal transition, and cancer drug resistance.

    Alterations in pre-mRNA splicing lead to numerous diseases, including cancer. We have a long-standing interest in regulation of gene expression at the level of RNA processing, in particular pre-mRNA splicing. The essential splicing factor U2AF, which initiates spliceosome assembly by binding to the intronic polypyrimidine tract/3’ splice site, was originally discovered in our laboratory. Subsequent cancer genome sequencing studies revealed driver mutations in the U2AF 35 kDa subunit (U2AF35). We have shown that oncogenic U2AF35 mutants promote transformation through mis-regulation of both spicing and mRNA 3’ end formation (Park et al. 2016). We are continuing to investigate the role of aberrant RNA processing in cancer as well as other diseases.

    Modulating Gene Expression as a Therapeutic Approach

    Factors that drive cancer progression are often not druggable and thus their therapeutic inhibition is challenging. We are taking a novel approach to identify inhibitors of these “undruggable” cancer-promoting factors. First, we have developed and carried out reporter-based CRISPR screening strategies to identify factors and pathways required for expression of a cancer-promoting gene. Based upon this information, we then identify biological or small molecule inhibitors of these factors and pathways, which abrogate expression of the cancer-promoting gene and suppress tumor growth. We have used this approach to identify inhibitors of expression of oncogenes and other genes that affect tumor development such as suppressors of anti-tumor immunity. This approach can also be used to identify antagonists of proteins that cause diseases other than cancer, such as neurodegenerative diseases.

    Cancer and other diseases can also arise due to the inappropriate transcriptional inactivation of specific genes. My lab has developed and successfully used functional genomic and proteomic approaches to identify factors and pathways involved in epigenetic silencing of tumor suppressor genes. Biological or small molecule inhibitors of these factors and pathways can reactivate expression of the tumor suppressor gene, which is a therapeutic approach that can be used to treat cancer. For example, we have delineated two independent oncoprotein-directed pathways that lead to widespread DNA hypermethylation and epigenetic silencing (known as the CpG island methylator phenotype; CIMP) in colorectal cancers, and shown that genetic or pharmacological inhibition of the pathways can reactivate expression of the silenced genes (Serra et al. 2014; Fang et al. 2014). The epigenetic silencing pathways we have identified are directly linked to cellular transformation, have enhanced our understanding of how normal cells become cancerous, and have revealed new therapeutic targets.

    We are taking a similar approach to identify small molecule inhibitors that will reactivate genes whose aberrant epigenetic silencing causes rare monogenic disorders such as Fragile X Syndrome and Friedreich ataxia. We also work on X-linked dominant disorders, such as Rett Syndrome and CDKL5 Deficiency, which are caused by heterozygous mutations in the X-linked genes MECP2 and CDKL5, respectively, and for which reactivation of the wild-type gene on the inactive X chromosome (Xi) is a potential therapeutic approach. For example, we have identified a number of cellular factors that are required for silencing of the Xi (Bhatnagar et al. 2014). Small molecule inhibitors of these factors can reactivate expression of the wild-type Xi-linked MECP2 gene in cultured cells and cerebral cortical neurons of adult living mice (Bhatnagar et al. 2014; Przanowski et al., 2018).

    Development of New Gene Therapy Approaches

    We have previously identified IGFBP7 (insulin-like growth factor binding protein 7) as a secreted tumor suppressor protein and shown in mouse models that systemic administration of recombinant IGFBP7 can suppress tumor growth of human melanoma and colorectal cancer xenografts expressing oncogenic BRAF or RAS (Wajapeyee et al. 2008, 2009). More recently, in collaboration with Dr. Guangping Gao (Director, UMMS Gene Therapy Center) we have shown that IGFBP7 can also be effectively delivered into mice using an adeno-associated virus (AAV) vector. Intramuscular injection of an AAV9-IGFBP7 vector results in the expression and secretion of IGFBP7 and markedly reduces growth of human melanoma and colorectal cancer xenografts. We have confirmed the generality of this approach using another secreted tumor suppressor protein. Our results indicate that AAV9 delivery of secreted tumor suppressors is a new and promising anti-cancer treatment.

    In collaboration with Guangping Gao and Miguel Sena-Esteves (UMMS Gene Therapy Center), we are developing a novel AAV-based gene therapy approach for Rett Syndrome. Several lines of evidence indicate that MECP2 expression levels must be tightly regulated to maintain normal neuronal function and development. We are therefore developing self-regulating AAV vectors that can express MECP2 within a narrow range of levels compatible with normal development and neuronal function.

    Collapse Rotation Projects

    Rotation Projects

    Numerous rotation projects are available to work on a variety of ongoing problems in eukaryotic gene regulation at the transcriptional and post-transcriptional levels, and the relevance of gene regulation to certain human disease states. Rotation projects are individually tailored to the research interests and objectives of each student.

    Collapse Post Docs
    A postdoctoral position is available to study in this laboratory. Please contact Dr. Green for additional details.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Han G, Deng Q, Marques-Piubelli ML, Dai E, Dang M, Ma MCJ, Li X, Yang H, Henderson J, Kudryashova O, Meerson M, Isaev S, Kotlov N, Nomie KJ, Bagaev A, Parra ER, Solis Soto LM, Parmar S, Hagemeister FB, Ahmed S, Iyer SP, Samaniego F, Steiner R, Fayad L, Lee H, Fowler NH, Flowers CR, Strati P, Westin JR, Neelapu SS, Nastoupil LJ, Vega F, Wang L, Green MR. Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression. Blood Cancer Discov. 2022 09 06; 3(5):428-443. PMID: 35687817.
      Citations:    Fields:    
    2. Cherng HJ, Sun R, Sugg B, Irwin R, Yang H, Le CC, Deng Q, Fayad L, Fowler NH, Parmar S, Steiner R, Hagemeister F, Nair R, Lee HJ, Rodriguez M, Samaniego F, Iyer SP, Flowers CR, Wang L, Nastoupil LJ, Neelapu SS, Ahmed S, Strati P, Green MR, Westin J. Risk assessment with low-pass whole-genome sequencing of cell-free DNA before CD19 CAR T-cell therapy for large B-cell lymphoma. Blood. 2022 08 04; 140(5):504-515. PMID: 35512184.
      Citations:    Fields:    
    3. Rushton MD, Saunderson EA, Patani H, Green MR, Ficz G. An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells. Epigenetics. 2022 Dec; 17(12):1590-1607. PMID: 35324392.
      Citations:    Fields:    
    4. Mill CP, Fiskus W, DiNardo CD, Birdwell C, Davis JA, Kadia TM, Takahashi K, Short N, Daver N, Ohanian M, Borthakur G, Kornblau SM, Green MR, Qi Y, Su X, Khoury JD, Bhalla KN. Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2. Blood. 2022 02 10; 139(6):907-921. PMID: 34601571.
      Citations: 1     Fields:    Translation:HumansCells
    5. Szyd?owski M, Garbicz F, Jab?o?ska E, Górniak P, Komar D, Pyrzy?ska B, Bojarczuk K, Prochorec-Sobieszek M, Szumera-Cie?kiewicz A, Rymkiewicz G, Cybulska M, Statkiewicz M, Gajewska M, Mikula M, Go?as A, Domaga?a J, Winiarska M, Graczyk-Jarzynka A, Bia?opiotrowicz E, Polak A, Barankiewicz J, Pu?a B, Pawlak M, Nowis D, Golab J, Tomirotti AM, Brzózka K, Pacheco-Blanco M, Kupcova K, Green MR, Havranek O, Chapuy B, Juszczy?ski P. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies. Cancer Res. 2021 12 01; 81(23):6029-6043. PMID: 34625423.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Bugide S, Gupta R, Green MR, Wajapeyee N. EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner. Proc Natl Acad Sci U S A. 2021 07 27; 118(30). PMID: 34301901.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    7. Strati P, Ahmed S, Furqan F, Fayad LE, Lee HJ, Iyer SP, Nair R, Nastoupil LJ, Parmar S, Rodriguez MA, Samaniego F, Steiner RE, Wang M, Pinnix CC, Horowitz SB, Feng L, Sun R, Claussen CM, Hawkins MC, Johnson NA, Singh P, Mistry H, Johncy S, Adkins S, Kebriaei P, Shpall EJ, Green MR, Flowers CR, Westin J, Neelapu SS. Prognostic impact of corticosteroids on efficacy of chimeric antigen receptor T-cell therapy in large B-cell lymphoma. Blood. 2021 06 10; 137(23):3272-3276. PMID: 33534891.
      Citations: 22     Fields:    Translation:Humans
    8. Roderick JE, Gallagher KM, Murphy LC, O'Connor KW, Tang K, Zhang B, Brehm MA, Greiner DL, Yu J, Zhu LJ, Green MR, Kelliher MA. Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. 2021 01 28; 137(4):500-512. PMID: 33507291.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Yang H, Green MR. Harnessing lymphoma epigenetics to improve therapies. Blood. 2020 Nov 18. PMID: 33206943.
      Citations: 2     Fields:    
    10. Ou J, Liu H, Nirala NK, Stukalov A, Acharya U, Green MR, Zhu LJ. dagLogo: An R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data. PLoS One. 2020; 15(11):e0242030. PMID: 33156866.
      Citations: 1     Fields:    Translation:HumansCells
    11. Li R, Hu K, Liu H, Green MR, Zhu LJ. OneStopRNAseq: A Web Application for Comprehensive and Efficient Analyses of RNA-Seq Data. Genes (Basel). 2020 10 02; 11(10). PMID: 33023248.
      Citations: 7     Fields:    Translation:HumansCells
    12. Swenson SA, Gilbreath TJ, Vahle H, Hynes-Smith RW, Graham JH, Law HC, Amador C, Woods NT, Green MR, Buckley SM. UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells. Blood. 2020 07 16; 136(3):299-312. PMID: 32325489.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Gallagher KM, Roderick JE, Tan SH, Tan TK, Murphy L, Yu J, Li R, O'Connor KW, Zhu J, Green MR, Sanda T, Kelliher MA. ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia. Blood Adv. 2020 07 14; 4(13):3154-3168. PMID: 32658986.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, Béguelin W, Lee TC, Kim Y, Chin CR, Yewdell WT, Raught B, Phillip JM, Jiang Y, Staudt LM, Green MR, Chaudhuri J, Elemento O, Farinha P, Weng AP, Nissen MD, Steidl C, Morin RD, Scott DW, Privé GG, Melnick AM. TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. 2020 07 23; 182(2):297-316.e27. PMID: 32619424.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, Garcia-Bermudez J, Cho BK, Tam W, Kelleher NL, Socci N, Dogan A, De Stanchina E, Ciriello G, Green MR, Li S, Birsoy K, Melnick AM, Wendel HG. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nat Cancer. 2020; 1:653-664. PMID: 33569544.
    16. Gupta R, Malvi P, Parajuli KR, Janostiak R, Bugide S, Cai G, Zhu LJ, Green MR, Wajapeyee N. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12341-12351. PMID: 32430335.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    17. Saenz DT, Fiskus W, Mill CP, Perera D, Manshouri T, Lara BH, Karkhanis V, Sharma S, Horrigan SK, Bose P, Kadia TM, Masarova L, DiNardo CD, Borthakur G, Khoury JD, Takahashi K, Bhaskara S, Lin CY, Green MR, Coarfa C, Crews CM, Verstovsek S, Bhalla KN. Mechanistic basis and efficacy of targeting the ?-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors. Blood. 2020 04 09; 135(15):1255-1269. PMID: 32068780.
      Citations: 9     Fields:    Translation:HumansCells
    18. Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood. 2019 11 28; 134(22):1960-1972. PMID: 31515251.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    19. Guo S, Pridham KJ, Virbasius CM, He B, Zhang L, Varmark H, Green MR, Sheng Z. Author Correction: A large-scale RNA interference screen identifies genes that regulate autophagy at different stages. Sci Rep. 2019 Jun 10; 9(1):8382. PMID: 31182720.
      Citations:    Fields:    
    20. Ma L, Pak ML, Ou J, Yu J, St Louis P, Shan Y, Hutchinson L, Li S, Brehm MA, Zhu LJ, Green MR. Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10482-10487. PMID: 31068472.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KN. RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. Blood. 2019 07 04; 134(1):59-73. PMID: 31023702.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    22. Gupta R, Bugide S, Wang B, Green MR, Johnson DB, Wajapeyee N. Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4583-4591. PMID: 30782837.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    23. Przanowski P, Wasko U, Zheng Z, Yu J, Sherman R, Zhu LJ, McConnell MJ, Tushir-Singh J, Green MR, Bhatnagar S. Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):7991-7996. PMID: 30012595.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Vicente-Dueñas C, González-Herrero I, Sehgal L, García-Ramírez I, Rodríguez-Hernández G, Pintado B, Blanco O, Criado FJG, Cenador MBG, Green MR, Sánchez-García I. Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia. Leukemia. 2019 01; 33(1):249-278. PMID: 29955131.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    25. Himeda CL, Jones TI, Virbasius CM, Zhu LJ, Green MR, Jones PL. Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy. Mol Ther. 2018 07 05; 26(7):1797-1807. PMID: 29759937.
      Citations: 12     Fields:    Translation:HumansCells
    26. Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Nat Cell Biol. 2018 05; 20(5):586-596. PMID: 29695787.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    27. Bugide S, Green MR, Wajapeyee N. Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3509-E3518. PMID: 29581297.
      Citations: 49     Fields:    Translation:HumansCells
    28. Guo S, Pridham KJ, Virbasius CM, He B, Zhang L, Varmark H, Green MR, Sheng Z. A large-scale RNA interference screen identifies genes that regulate autophagy at different stages. Sci Rep. 2018 02 12; 8(1):2822. PMID: 29434216.
      Citations: 6     Fields:    Translation:HumansCells
    29. Choppara S, Malonia SK, Sankaran G, Green MR, Santra MK. Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):998-1003. PMID: 29343641.
      Citations: 8     Fields:    Translation:HumansCells
    30. Janostiak R, Rauniyar N, Lam TT, Ou J, Zhu LJ, Green MR, Wajapeyee N. MELK Promotes Melanoma Growth by Stimulating the NF-?B Pathway. Cell Rep. 2017 Dec 05; 21(10):2829-2841. PMID: 29212029.
      Citations: 36     Fields:    Translation:HumansCells
    31. Green MR. Chromatin modifying gene mutations in follicular lymphoma. Blood. 2018 02 08; 131(6):595-604. PMID: 29158360.
      Citations: 35     Fields:    Translation:HumansCells
    32. Ma L, Boucher JI, Paulsen J, Matuszewski S, Eide CA, Ou J, Eickelberg G, Press RD, Zhu LJ, Druker BJ, Branford S, Wolfe SA, Jensen JD, Schiffer CA, Green MR, Bolon DN. CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):11751-11756. PMID: 29078326.
      Citations: 21     Fields:    Translation:AnimalsCells
    33. Bou Samra E, Buhagiar-Labarchède G, Machon C, Guitton J, Onclercq-Delic R, Green MR, Alibert O, Gazin C, Veaute X, Amor-Guéret M. A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. Nat Commun. 2017 09 25; 8(1):693. PMID: 28947735.
      Citations: 16     Fields:    Translation:HumansCells
    34. Ee LS, McCannell KN, Tang Y, Fernandes N, Hardy WR, Green MR, Chu F, Fazzio TG. An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5. Stem Cell Reports. 2017 06 06; 8(6):1488-1496. PMID: 28528697.
      Citations: 10     Fields:    Translation:AnimalsCells
    35. Mou H, Moore J, Malonia SK, Li Y, Ozata DM, Hough S, Song CQ, Smith JL, Fischer A, Weng Z, Green MR, Xue W. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):3648-3653. PMID: 28320962.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    36. García-Ramírez I, Tadros S, González-Herrero I, Martín-Lorenzo A, Rodríguez-Hernández G, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, Rivas JL, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, Criado FJG, Cenador MBG, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice. Blood. 2017 05 11; 129(19):2645-2656. PMID: 28288979.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    37. Juliana CA, Yang J, Rozo AV, Good A, Groff DN, Wang SZ, Green MR, Stoffers DA. ATF5 regulates ?-cell survival during stress. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1341-1346. PMID: 28115692.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    38. Misra A, Green MR. Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Methods Mol Biol. 2017; 1507:1-12. PMID: 27832528.
      Citations: 1     Fields:    Translation:HumansCells
    39. Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, Wälchli S, Green MR, Trøen G, Liestøl K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R. Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood. 2017 02 09; 129(6):759-770. PMID: 28011673.
      Citations: 37     Fields:    Translation:HumansCells
    40. Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun. 2016 08 31; 7:12639. PMID: 27577745.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    41. Pedanou VE, Gobeil S, Tabariès S, Simone TM, Zhu LJ, Siegel PM, Green MR. The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L. Elife. 2016 07 29; 5. PMID: 27472901.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    42. Park SM, Ou J, Chamberlain L, Simone TM, Yang H, Virbasius CM, Ali AM, Zhu LJ, Mukherjee S, Raza A, Green MR. U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation. Mol Cell. 2016 05 19; 62(4):479-90. PMID: 27184077.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    43. Agrawal AA, Salsi E, Chatrikhi R, Henderson S, Jenkins JL, Green MR, Ermolenko DN, Kielkopf CL. An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nat Commun. 2016 Mar 08; 7:10950. PMID: 26952537.
      Citations: 32     Fields:    Translation:HumansCells
    44. Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L. Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1460-9. PMID: 26929344.
      Citations: 12     Fields:    Translation:AnimalsCells
    45. Fang M, Hutchinson L, Deng A, Green MR. Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1250-5. PMID: 26787892.
      Citations: 30     Fields:    Translation:HumansCells
    46. Ma L, Roderick J, Kelliher MA, Green MR. High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML. Methods Mol Biol. 2016; 1465:159-73. PMID: 27581147.
      Citations: 4     Fields:    Translation:HumansCells
    47. Misra A, Green MR. From polyadenylation to splicing: Dual role for mRNA 3' end formation factors. RNA Biol. 2016; 13(3):259-64. PMID: 26891005.
      Citations: 16     Fields:    Translation:HumansCells
    48. Misra A, Ou J, Zhu LJ, Green MR. Global analysis of CPSF2-mediated alternative splicing: Integration of global iCLIP and transcriptome profiling data. Genom Data. 2015 Dec; 6:217-21. PMID: 26697379.
    49. Malonia SK, Dutta P, Santra MK, Green MR. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8632-7. PMID: 26124108.
      Citations: 28     Fields:    Translation:HumansCells
    50. Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol. 2015 Jul; 16(7):746-54. PMID: 26030024.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    51. Fang M, Pak ML, Chamberlain L, Xing W, Yu H, Green MR. The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes. Cell Rep. 2015 Jun 09; 11(9):1350-7. PMID: 26004186.
      Citations: 17     Fields:    Translation:HumansCells
    52. Misra A, Ou J, Zhu LJ, Green MR. Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors. Mol Cell. 2015 Jun 04; 58(5):819-31. PMID: 25921069.
      Citations: 23     Fields:    Translation:HumansCells
    53. Kurtz DM, Green MR, Bratman SV, Scherer F, Liu CL, Kunder CA, Takahashi K, Glover C, Keane C, Kihira S, Visser B, Callahan J, Kong KA, Faham M, Corbelli KS, Miklos D, Advani RH, Levy R, Hicks RJ, Hertzberg M, Ohgami RS, Gandhi MK, Diehn M, Alizadeh AA. Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood. 2015 Jun 11; 125(24):3679-87. PMID: 25887775.
      Citations: 109     Fields:    Translation:Humans
    54. Guillemette S, Serra RW, Peng M, Hayes JA, Konstantinopoulos PA, Green MR, Cantor SB. Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4. Genes Dev. 2015 Mar 01; 29(5):489-94. PMID: 25737278.
      Citations: 74     Fields:    Translation:HumansCells
    55. Bhatnagar S, Green MR. TRIMming down tumor suppressors in breast cancer. Cell Cycle. 2015; 14(9):1345-6. PMID: 25790001.
      Citations: 4     Fields:    Translation:HumansCells
    56. Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir JS, Virbasius CM, Lin L, Zhu LJ, Wajapeyee N, Green MR. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014 Dec 04; 516(7529):116-20. PMID: 25470042.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    57. Fang M, Ou J, Hutchinson L, Green MR. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014 Sep 18; 55(6):904-915. PMID: 25219500.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    58. Moon H, Cho S, Loh TJ, Oh HK, Jang HN, Zhou J, Kwon YS, Liao DJ, Jun Y, Eom S, Ghigna C, Biamonti G, Green MR, Zheng X, Shen H. SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene. Biochim Biophys Acta. 2014 Nov; 1839(11):1132-40. PMID: 25220236.
      Citations: 12     Fields:    Translation:HumansCells
    59. Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR. A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia. Sci Transl Med. 2014 Sep 03; 6(252):252ra121. PMID: 25186176.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    60. Bhatnagar S, Zhu X, Ou J, Lin L, Chamberlain L, Zhu LJ, Wajapeyee N, Green MR. Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12591-8. PMID: 25136103.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    61. Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR, Wajapeyee N. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):E3062-71. PMID: 25024194.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    62. Lin L, Chamberlain L, Pak ML, Nagarajan A, Gupta R, Zhu LJ, Wright CM, Fong KM, Wajapeyee N, Green MR. A large-scale RNAi-based mouse tumorigenesis screen identifies new lung cancer tumor suppressors that repress FGFR signaling. Cancer Discov. 2014 Oct; 4(10):1168-81. PMID: 25015643.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    63. Green MR, Vicente-Dueñas C, Romero-Camarero I, Long Liu C, Dai B, González-Herrero I, García-Ramírez I, Alonso-Escudero E, Iqbal J, Chan WC, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jiménez R, Martínez-Climent JA, Criado FJ, Cenador MB, Zhao S, Natkunam Y, Lossos IS, Majeti R, Melnick A, Cobaleda C, Alizadeh AA, Sánchez-García I. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nat Commun. 2014 Jun 02; 5:3904. PMID: 24887457.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    64. Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL. Cancer-relevant splicing factor CAPER? engages the essential splicing factor SF3b155 in a specific ternary complex. J Biol Chem. 2014 Jun 20; 289(25):17325-37. PMID: 24795046.
      Citations: 25     Fields:    Translation:HumansCells
    65. Nagarajan A, Dogra SK, Liu AY, Green MR, Wajapeyee N. PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation. Mol Cell Biol. 2014 Jun; 34(12):2264-82. PMID: 24710276.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    66. Cho S, Moon H, Loh TJ, Oh HK, Williams DR, Liao DJ, Zhou J, Green MR, Zheng X, Shen H. PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion. Biochim Biophys Acta. 2014 Jun; 1839(6):517-25. PMID: 24632473.
      Citations: 18     Fields:    Translation:HumansCells
    67. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12; 3:e02313. PMID: 24623306.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    68. Zheng X, Cho S, Moon H, Loh TJ, Oh HK, Green MR, Shen H. Polypyrimidine tract binding protein inhibits IgM pre-mRNA splicing by diverting U2 snRNA base-pairing away from the branch point. RNA. 2014 Apr; 20(4):440-6. PMID: 24572809.
      Citations: 3     Fields:    Translation:AnimalsCells
    69. Forloni M, Dogra SK, Dong Y, Conte D, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR, Wajapeyee N. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Elife. 2014 Feb 18; 3:e01460. PMID: 24550252.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    70. Sheng Z, Murphy SF, Guo S, Green MR. A diphtheria toxin negative selection in RNA interference screening. Methods Mol Biol. 2014; 1176:59-72. PMID: 25030919.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    71. Jang HN, Lee M, Loh TJ, Choi SW, Oh HK, Moon H, Cho S, Hong SE, Kim DH, Sheng Z, Green MR, Park D, Zheng X, Shen H. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8. Biochim Biophys Acta. 2014 Jan; 1839(1):25-32. PMID: 24321384.
      Citations: 14     Fields:    Translation:HumansCells
    72. Moon H, Cho S, Loh TJ, Zhou J, Ghigna C, Biamonti G, Green MR, Zheng X, Shen H. A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene. Oncol Rep. 2014 Jan; 31(1):450-5. PMID: 24189591.
      Citations: 3     Fields:    Translation:HumansCells
    73. Loh TJ, Moon H, Cho S, Jung DW, Hong SE, Kim DH, Green MR, Zheng X, Zhou J, Shen H. SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA. Oncol Rep. 2014 Jan; 31(1):273-9. PMID: 24173428.
      Citations: 11     Fields:    Translation:HumansCells
    74. Wagenaar TR, Ma L, Roscoe B, Park SM, Bolon DN, Green MR. Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. Pigment Cell Melanoma Res. 2014 Jan; 27(1):124-33. PMID: 24112705.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    75. Wajapeyee N, Malonia SK, Palakurthy RK, Green MR. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15; 27(20):2221-6. PMID: 24105743.
      Citations: 23     Fields:    Translation:AnimalsCells
    76. Pistis G, Okonkwo SU, Traglia M, Sala C, Shin SY, Masciullo C, Buetti I, Massacane R, Mangino M, Thein SL, Spector TD, Ganesh S, Pirastu N, Gasparini P, Soranzo N, Camaschella C, Hart D, Green MR, Toniolo D. Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans. PLoS One. 2013; 8(7):e69206. PMID: 23935956.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    77. Oh Hk, Lee E, Jang HN, Lee J, Moon H, Sheng Z, Jun Y, Loh TJ, Cho S, Zhou J, Green MR, Zheng X, Shen H. hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene. Apoptosis. 2013 Jul; 18(7):825-35. PMID: 23430061.
      Citations: 11     Fields:    Translation:HumansCells
    78. Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N, Green MR. MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair. Mol Cell Biol. 2013 Jul; 33(13):2635-47. PMID: 23648481.
      Citations: 20     Fields:    Translation:HumansCells
    79. Jenkins JL, Agrawal AA, Gupta A, Green MR, Kielkopf CL. U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res. 2013 Apr 01; 41(6):3859-73. PMID: 23376934.
      Citations: 21     Fields:    Translation:HumansCells
    80. Yang ZF, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green MR, Li S, Rosmarin AG. GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2312-7. PMID: 23345428.
      Citations: 15     Fields:    Translation:AnimalsCells
    81. Green MR, Gentles AJ, Nair RV, Irish JM, Kihira S, Liu CL, Kela I, Hopmans ES, Myklebust JH, Ji H, Plevritis SK, Levy R, Alizadeh AA. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. 2013 Feb 28; 121(9):1604-11. PMID: 23297126.
      Citations: 127     Fields:    Translation:HumansCells
    82. Myklebust JH, Irish JM, Brody J, Czerwinski DK, Houot R, Kohrt HE, Timmerman J, Said J, Green MR, Delabie J, Kolstad A, Alizadeh AA, Levy R. High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells. Blood. 2013 Feb 21; 121(8):1367-76. PMID: 23297127.
      Citations: 73     Fields:    Translation:HumansCells
    83. Wajapeyee N, Deibler SK, Green MR. Genome-wide RNAi screening to identify regulators of oncogene-induced cellular senescence. Methods Mol Biol. 2013; 965:373-82. PMID: 23296672.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    84. Wang W, Maucuer A, Gupta A, Manceau V, Thickman KR, Bauer WJ, Kennedy SD, Wedekind JE, Green MR, Kielkopf CL. Structure of phosphorylated SF1 bound to U2AF?? in an essential splicing factor complex. Structure. 2013 Feb 05; 21(2):197-208. PMID: 23273425.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    85. Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. PLoS Genet. 2012; 8(12):e1003151. PMID: 23284306.
      Citations: 15     Fields:    Translation:HumansCells
    86. Maston GA, Zhu LJ, Chamberlain L, Lin L, Fang M, Green MR. Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. Elife. 2012 Nov 13; 1:e00068. PMID: 23150797.
      Citations: 22     Fields:    Translation:HumansCells
    87. Wang SZ, Ou J, Zhu LJ, Green MR. Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18589-94. PMID: 23090999.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    88. Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Li S. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet. 2012 Jul 15; 44(8):861-71. PMID: 22797726.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    89. Maston GA, Landt SG, Snyder M, Green MR. Characterization of enhancer function from genome-wide analyses. Annu Rev Genomics Hum Genet. 2012; 13:29-57. PMID: 22703170.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    90. Den RB, Kamrava M, Sheng Z, Werner-Wasik M, Dougherty E, Marinucchi M, Lawrence YR, Hegarty S, Hyslop T, Andrews DW, Glass J, Friedman DP, Green MR, Camphausen K, Dicker AP. A phase I study of the combination of sorafenib with temozolomide and radiation therapy for the treatment of primary and recurrent high-grade gliomas. Int J Radiat Oncol Biol Phys. 2013 Feb 01; 85(2):321-8. PMID: 22687197.
      Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
    91. Lin L, Chamberlain L, Zhu LJ, Green MR. Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1997-2002. PMID: 22308403.
      Citations: 15     Fields:    Translation:AnimalsCells
    92. Wajapeyee N, Green MR. Induction of senescence in melanoma: thinking outside the cell. Pigment Cell Melanoma Res. 2011 Oct; 24(5):874-5. PMID: 22081810.
      Citations:    Fields:    Translation:Humans
    93. Sheng Z, Ma L, Sun JE, Zhu LJ, Green MR. BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 2011 Sep 08; 118(10):2840-8. PMID: 21715304.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    94. Liu Z, Yang A, Wang Z, Bunting KD, Davuluri G, Green MR, Devireddy LR. Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. J Biol Chem. 2011 Jun 10; 286(23):20606-14. PMID: 21507940.
      Citations: 12     Fields:    Translation:AnimalsCells
    95. Shen H, Zheng X, Luecke S, Green MR. The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing. Genes Dev. 2010 Nov 01; 24(21):2389-94. PMID: 21041408.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    96. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81. PMID: 20962847.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    97. Sheng Z, Evans SK, Green MR. An activating transcription factor 5-mediated survival pathway as a target for cancer therapy? Oncotarget. 2010 Oct; 1(6):457-60. PMID: 21311102.
      Citations: 13     Fields:    Translation:HumansAnimals
    98. Devireddy LR, Hart DO, Goetz DH, Green MR. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell. 2010 Jun 11; 141(6):1006-17. PMID: 20550936.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    99. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR. Role for IGFBP7 in senescence induction by BRAF. Cell. 2010 May 28; 141(5):746-7. PMID: 20510919.
      Citations: 20     Fields:    Translation:HumansCells
    100. Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med. 2010 Jun; 16(6):671-7. PMID: 20495567.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    101. Zhu LJ, Gazin C, Lawson ND, Pagès H, Lin SM, Lapointe DS, Green MR. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data. BMC Bioinformatics. 2010 May 11; 11:237. PMID: 20459804.
      Citations: 424     Fields:    Translation:Cells
    102. Wajapeyee N, Wang SZ, Serra RW, Solomon PD, Nagarajan A, Zhu X, Green MR. Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins. Blood. 2010 Jun 17; 115(24):5057-60. PMID: 20421454.
      Citations: 12     Fields:    Translation:HumansCells
    103. Wajapeyee N, Kapoor V, Mahalingam M, Green MR. Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Mol Cancer Ther. 2009 Nov; 8(11):3009-14. PMID: 19861408.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    104. Palakurthy RK, Wajapeyee N, Santra MK, Gazin C, Lin L, Gobeil S, Green MR. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell. 2009 Oct 23; 36(2):219-30. PMID: 19854132.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    105. Hart DO, Santra MK, Raha T, Green MR. Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis. Dev Dyn. 2009 Oct; 238(10):2540-9. PMID: 19777587.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    106. Emley A, Yang S, Wajapeyee N, Green MR, Mahalingam M. Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations. J Cutan Pathol. 2010 Mar; 37(3):344-9. PMID: 19788444.
      Citations: 5     Fields:    Translation:Humans
    107. Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR. Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. Cancer Res. 2009 Sep 01; 69(17):6782-9. PMID: 19706769.
      Citations: 65     Fields:    Translation:HumansCells
    108. Santra MK, Wajapeyee N, Green MR. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature. 2009 Jun 04; 459(7247):722-5. PMID: 19412162.
      Citations: 127     Fields:    Translation:HumansCells
    109. Sheng Z, Wang SZ, Green MR. Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. EMBO J. 2009 Apr 08; 28(7):866-76. PMID: 19229297.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    110. Gobeil S, Zhu X, Doillon CJ, Green MR. A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev. 2008 Nov 01; 22(21):2932-40. PMID: 18981472.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    111. Hart DO, Green MR. Targeting a TAF to make muscle. Mol Cell. 2008 Oct 24; 32(2):164-6. PMID: 18951083.
      Citations: 1     Fields:    Translation:AnimalsCells
    112. Jenkins JL, Shen H, Green MR, Kielkopf CL. Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65. J Biol Chem. 2008 Nov 28; 283(48):33641-9. PMID: 18842594.
      Citations: 19     Fields:    Translation:HumansCells
    113. Green MR. Senescence: not just for tumor suppression. Cell. 2008 Aug 22; 134(4):562-4. PMID: 18724927.
      Citations: 8     Fields:    Translation:HumansAnimals
    114. Shen H, Zheng X, Shen J, Zhang L, Zhao R, Green MR. Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev. 2008 Jul 01; 22(13):1796-803. PMID: 18593880.
      Citations: 51     Fields:    Translation:HumansCells
    115. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008 Feb 08; 132(3):363-74. PMID: 18267069.
      Citations: 395     Fields:    Translation:HumansAnimalsCells
    116. Hart DO, Raha T, Lawson ND, Green MR. Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 2007 Dec 13; 450(7172):1082-5. PMID: 18046332.
      Citations: 41     Fields:    Translation:Animals
    117. Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007 Oct 25; 449(7165):1073-7. PMID: 17960246.
      Citations: 151     Fields:    Translation:AnimalsCells
    118. Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH. Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J Virol. 2008 Jan; 82(1):529-37. PMID: 17942546.
      Citations: 22     Fields:    Translation:HumansCells
    119. Garifulin O, Qi Z, Shen H, Patnala S, Green MR, Boyartchuk V. Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection. PLoS Genet. 2007 Sep; 3(9):1587-97. PMID: 17845078.
      Citations: 13     Fields:    Translation:AnimalsCells
    120. Shen H, Green MR. RS domain-splicing signal interactions in splicing of U12-type and U2-type introns. Nat Struct Mol Biol. 2007 Jul; 14(7):597-603. PMID: 17603499.
      Citations: 25     Fields:    Translation:HumansCells
    121. Teodoro JG, Evans SK, Green MR. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. J Mol Med (Berl). 2007 Nov; 85(11):1175-86. PMID: 17589818.
      Citations: 84     Fields:    Translation:HumansAnimals
    122. Teodoro JG, Parker AE, Zhu X, Green MR. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science. 2006 Aug 18; 313(5789):968-71. PMID: 16917063.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    123. Heilman DW, Teodoro JG, Green MR. Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. J Virol. 2006 Aug; 80(15):7535-45. PMID: 16840333.
      Citations: 31     Fields:    Translation:HumansCells
    124. Sickmier EA, Frato KE, Shen H, Paranawithana SR, Green MR, Kielkopf CL. Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65. Mol Cell. 2006 Jul 07; 23(1):49-59. PMID: 16818232.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    125. Shen H, Green MR. RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev. 2006 Jul 01; 20(13):1755-65. PMID: 16766678.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    126. Maston GA, Evans SK, Green MR. Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet. 2006; 7:29-59. PMID: 16719718.
      Citations: 336     Fields:    Translation:Humans
    127. Evans SK, Aiello DP, Green MR. Fluorescence resonance energy transfer as a method for dissecting in vivo mechanisms of transcriptional activation. Biochem Soc Symp. 2006; (73):217-24. PMID: 16626301.
      Citations:    Fields:    Translation:AnimalsCells
    128. Devireddy LR, Gazin C, Zhu X, Green MR. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell. 2005 Dec 29; 123(7):1293-305. PMID: 16377569.
      Citations: 251     Fields:    Translation:HumansAnimalsCells
    129. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet. 2006 Feb; 38(2):251-7. PMID: 16380712.
      Citations: 183     Fields:    Translation:Animals
    130. Ghigna C, Giordano S, Shen H, Benvenuto F, Castiglioni F, Comoglio PM, Green MR, Riva S, Biamonti G. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol Cell. 2005 Dec 22; 20(6):881-90. PMID: 16364913.
      Citations: 204     Fields:    Translation:HumansCells
    131. Gabellini D, D'Antona G, Moggio M, Prelle A, Zecca C, Adami R, Angeletti B, Ciscato P, Pellegrino MA, Bottinelli R, Green MR, Tupler R. Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1. Nature. 2006 Feb 23; 439(7079):973-7. PMID: 16341202.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    132. Green MR. Eukaryotic transcription activation: right on target. Mol Cell. 2005 May 13; 18(4):399-402. PMID: 15893723.
      Citations: 31     Fields:    Translation:AnimalsCells
    133. Heilman DW, Green MR, Teodoro JG. The anaphase promoting complex: a critical target for viral proteins and anti-cancer drugs. Cell Cycle. 2005 Apr; 4(4):560-3. PMID: 15876865.
      Citations: 16     Fields:    Translation:Humans
    134. Raha T, Cheng SW, Green MR. HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs. PLoS Biol. 2005 Feb; 3(2):e44. PMID: 15719058.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    135. Shen H, Green MR. A pathway of sequential arginine-serine-rich domain-splicing signal interactions during mammalian spliceosome assembly. Mol Cell. 2004 Nov 05; 16(3):363-73. PMID: 15525510.
      Citations: 89     Fields:    Translation:HumansCells
    136. Teodoro JG, Heilman DW, Parker AE, Green MR. The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev. 2004 Aug 15; 18(16):1952-7. PMID: 15314021.
      Citations: 50     Fields:    Translation:HumansCells
    137. Zhao R, Shen J, Green MR, MacMorris M, Blumenthal T. Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure. 2004 Aug; 12(8):1373-81. PMID: 15296731.
      Citations: 22     Fields:    Translation:HumansCells
    138. Kielkopf CL, Lücke S, Green MR. U2AF homology motifs: protein recognition in the RRM world. Genes Dev. 2004 Jul 01; 18(13):1513-26. PMID: 15231733.
      Citations: 126     Fields:    Translation:Cells
    139. Gabellini D, Green MR, Tupler R. When enough is enough: genetic diseases associated with transcriptional derepression. Curr Opin Genet Dev. 2004 Jun; 14(3):301-7. PMID: 15172674.
      Citations: 9     Fields:    Translation:Humans
    140. Shen H, Kan JL, Ghigna C, Biamonti G, Green MR. A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2. RNA. 2004 May; 10(5):787-94. PMID: 15100434.
      Citations: 26     Fields:    Translation:AnimalsCells
    141. Shen H, Kan JL, Green MR. Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly. Mol Cell. 2004 Feb 13; 13(3):367-76. PMID: 14967144.
      Citations: 105     Fields:    Translation:HumansCells
    142. Bhaumik SR, Raha T, Aiello DP, Green MR. In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev. 2004 Feb 01; 18(3):333-43. PMID: 14871930.
      Citations: 96     Fields:    Translation:Cells
    143. Persengiev SP, Zhu X, Green MR. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA. 2004 Jan; 10(1):12-8. PMID: 14681580.
      Citations: 165     Fields:    Translation:HumansCells
    144. Persengiev SP, Zhu X, Dixit BL, Maston GA, Kittler EL, Green MR. TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14887-91. PMID: 14634207.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    145. Devireddy LR, Green MR. Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor. Mol Cell Biol. 2003 Jul; 23(13):4532-41. PMID: 12808095.
      Citations: 17     Fields:    Translation:HumansCells
    146. Shen WC, Bhaumik SR, Causton HC, Simon I, Zhu X, Jennings EG, Wang TH, Young RA, Green MR. Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. EMBO J. 2003 Jul 01; 22(13):3395-402. PMID: 12840001.
      Citations: 58     Fields:    Translation:AnimalsCells
    147. Gabellini D, Tupler R, Green MR. Transcriptional derepression as a cause of genetic diseases. Curr Opin Genet Dev. 2003 Jun; 13(3):239-45. PMID: 12787785.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    148. Persengiev SP, Green MR. The role of ATF/CREB family members in cell growth, survival and apoptosis. Apoptosis. 2003 Jun; 8(3):225-8. PMID: 12766482.
      Citations: 60     Fields:    Translation:HumansAnimals
    149. Reese JC, Green MR. Functional analysis of TFIID components using conditional mutants. Methods Enzymol. 2003; 370:415-30. PMID: 14712664.
      Citations: 12     Fields:    
    150. Bhaumik SR, Green MR. Interaction of Gal4p with components of transcription machinery in vivo. Methods Enzymol. 2003; 370:445-54. PMID: 14712666.
      Citations: 29     Fields:    Translation:HumansCells
    151. Bhaumik SR, Green MR. Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo. Mol Cell Biol. 2002 Nov; 22(21):7365-71. PMID: 12370284.
      Citations: 103     Fields:    Translation:AnimalsCells
    152. Gabellini D, Green MR, Tupler R. Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell. 2002 Aug 09; 110(3):339-48. PMID: 12176321.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    153. Li XY, Bhaumik SR, Zhu X, Li L, Shen WC, Dixit BL, Green MR. Selective recruitment of TAFs by yeast upstream activating sequences. Implications for eukaryotic promoter structure. Curr Biol. 2002 Jul 23; 12(14):1240-4. PMID: 12176335.
      Citations: 41     Fields:    Translation:AnimalsCells
    154. Persengiev SP, Devireddy LR, Green MR. Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. Genes Dev. 2002 Jul 15; 16(14):1806-14. PMID: 12130540.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    155. Gollan TJ, Green MR. Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands. J Virol. 2002 Apr; 76(7):3564-9. PMID: 11884581.
      Citations: 10     Fields:    Translation:HumansCells
    156. Gollan TJ, Green MR. Redirecting retroviral tropism by insertion of short, nondisruptive peptide ligands into envelope. J Virol. 2002 Apr; 76(7):3558-63. PMID: 11884580.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    157. Virbasius CM, Holstege FC, Young RA, Green MR. Promoter-specific activation defects by a novel yeast TBP mutant compromised for TFIIB interaction. Curr Biol. 2001 Nov 13; 11(22):1794-8. PMID: 11719223.
      Citations: 6     Fields:    Translation:AnimalsCells
    158. Devireddy LR, Teodoro JG, Richard FA, Green MR. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science. 2001 Aug 03; 293(5531):829-34. PMID: 11486081.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    159. Bhaumik SR, Green MR. SAGA is an essential in vivo target of the yeast acidic activator Gal4p. Genes Dev. 2001 Aug 01; 15(15):1935-45. PMID: 11485988.
      Citations: 163     Fields:    Translation:AnimalsCells
    160. Purohit P, Dupont S, Stevenson M, Green MR. Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection. RNA. 2001 Apr; 7(4):576-84. PMID: 11345436.
      Citations: 71     Fields:    Translation:Cells
    161. Tupler R, Perini G, Green MR. Expressing the human genome. Nature. 2001 Feb 15; 409(6822):832-3. PMID: 11237001.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    162. Zhang M, Green MR. Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56. Genes Dev. 2001 Jan 01; 15(1):30-5. PMID: 11156602.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    163. Li XY, Bhaumik SR, Green MR. Distinct classes of yeast promoters revealed by differential TAF recruitment. Science. 2000 May 19; 288(5469):1242-4. PMID: 10817999.
      Citations: 102     Fields:    Translation:AnimalsCells
    164. Green MR. TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes. Trends Biochem Sci. 2000 Feb; 25(2):59-63. PMID: 10664584.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    165. Wu S, Romfo CM, Nilsen TW, Green MR. Functional recognition of the 3' splice site AG by the splicing factor U2AF35. Nature. 1999 Dec 16; 402(6763):832-5. PMID: 10617206.
      Citations: 210     Fields:    Translation:HumansCells
    166. Dupont S, Sharova N, DéHoratius C, Virbasius CM, Zhu X, Bukrinskaya AG, Stevenson M, Green MR. A novel nuclear export activity in HIV-1 matrix protein required for viral replication. Nature. 1999 Dec 09; 402(6762):681-5. PMID: 10604476.
      Citations: 62     Fields:    Translation:HumansCells
    167. Tupler R, Perini G, Pellegrino MA, Green MR. Profound misregulation of muscle-specific gene expression in facioscapulohumeral muscular dystrophy. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12650-4. PMID: 10535977.
      Citations: 14     Fields:    Translation:HumansCells
    168. Virbasius CM, Wagner S, Green MR. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins. Mol Cell. 1999 Aug; 4(2):219-28. PMID: 10488337.
      Citations: 38     Fields:    Translation:HumansCells
    169. Li XY, Virbasius A, Zhu X, Green MR. Enhancement of TBP binding by activators and general transcription factors. Nature. 1999 Jun 10; 399(6736):605-9. PMID: 10376604.
      Citations: 113     Fields:    Translation:AnimalsCells
    170. Perini G, Oetjen E, Green MR. The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region. J Biol Chem. 1999 May 14; 274(20):13970-7. PMID: 10318808.
      Citations: 7     Fields:    Translation:HumansCells
    171. Kan JL, Green MR. Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev. 1999 Feb 15; 13(4):462-71. PMID: 10049361.
      Citations: 65     Fields:    Translation:HumansCells
    172. Shen WC, Green MR. Analysis of selective gene activation in yeast by differential display. Methods. 1998 Dec; 16(4):415-22. PMID: 10049649.
      Citations:    Fields:    Translation:AnimalsCells
    173. Apone LM, Virbasius CA, Holstege FC, Wang J, Young RA, Green MR. Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA. Mol Cell. 1998 Nov; 2(5):653-61. PMID: 9844637.
      Citations: 36     Fields:    Translation:AnimalsCells
    174. Werstuck G, Green MR. Controlling gene expression in living cells through small molecule-RNA interactions. Science. 1998 Oct 09; 282(5387):296-8. PMID: 9765156.
      Citations: 105     Fields:    Translation:AnimalsCells
    175. Li XY, Green MR. The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. Genes Dev. 1998 Oct 01; 12(19):2992-6. PMID: 9765201.
      Citations: 30     Fields:    Translation:HumansCells
    176. Shen WC, Apone LM, Virbasius CM, Li XY, Monsalve M, Green MR. Functional analysis of TFIID components. Cold Spring Harb Symp Quant Biol. 1998; 63:219-27. PMID: 10384285.
      Citations:    Fields:    Translation:HumansAnimalsCells
    177. Shen WC, Green MR. Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator. Cell. 1997 Aug 22; 90(4):615-24. PMID: 9288742.
      Citations: 75     Fields:    Translation:AnimalsCells
    178. Walker SS, Shen WC, Reese JC, Apone LM, Green MR. Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state. Cell. 1997 Aug 22; 90(4):607-14. PMID: 9288741.
      Citations: 60     Fields:    Translation:AnimalsCells
    179. Gaur RK, McLaughlin LW, Green MR. Functional group substitutions of the branchpoint adenosine in a nuclear pre-mRNA and a group II intron. RNA. 1997 Aug; 3(8):861-9. PMID: 9257645.
      Citations: 7     Fields:    Translation:Cells
    180. Wu S, Green MR. Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing. EMBO J. 1997 Jul 16; 16(14):4421-32. PMID: 9250686.
      Citations: 26     Fields:    Translation:HumansCells
    181. Fleckner J, Zhang M, Valcárcel J, Green MR. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 1997 Jul 15; 11(14):1864-72. PMID: 9242493.
      Citations: 119     Fields:    Translation:HumansCells
    182. Zhang G, Zapp ML, Yan G, Green MR. Localization of HIV-1 RNA in mammalian nuclei. J Cell Biol. 1996 Oct; 135(1):9-18. PMID: 8858159.
      Citations: 12     Fields:    Translation:HumansCells
    183. Valcárcel J, Gaur RK, Singh R, Green MR. Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected]. Science. 1996 Sep 20; 273(5282):1706-9. PMID: 8781232.
      Citations: 134     Fields:    Translation:Cells
    184. Apone LM, Virbasius CM, Reese JC, Green MR. Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation. Genes Dev. 1996 Sep 15; 10(18):2368-80. PMID: 8824595.
      Citations: 59     Fields:    Translation:AnimalsCells
    185. Walker SS, Reese JC, Apone LM, Green MR. Transcription activation in cells lacking TAFIIS. Nature. 1996 Sep 12; 383(6596):185-8. PMID: 8774886.
      Citations: 97     Fields:    Translation:AnimalsCells
    186. Li XY, Green MR. Transcriptional elongation and cancer. Tumorigenesis. Curr Biol. 1996 Aug 01; 6(8):943-4. PMID: 8805321.
      Citations: 1     Fields:    Translation:HumansCells
    187. Fritz CC, Green MR. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr Biol. 1996 Jul 01; 6(7):848-54. PMID: 8805303.
      Citations: 43     Fields:    Translation:HumansCells
    188. Green MR, Stillman B. Chromosomes and expression mechanisms. Curr Opin Genet Dev. 1996 Apr 01; 6(2):139-40. PMID: 8791494.
      Citations:    Fields:    
    189. Li XY, Green MR. Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain. Genes Dev. 1996 Mar 01; 10(5):517-27. PMID: 8598283.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    190. Denis GV, Green MR. A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 1996 Feb 01; 10(3):261-71. PMID: 8595877.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    191. Werstuck G, Zapp ML, Green MR. A non-canonical base pair within the human immunodeficiency virus rev-responsive element is involved in both rev and small molecule recognition. Chem Biol. 1996 Feb; 3(2):129-37. PMID: 8807838.
      Citations: 6     Fields:    Translation:Cells
    192. Perini G, Wagner S, Green MR. Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax. Nature. 1995 Aug 17; 376(6541):602-5. PMID: 7637811.
      Citations: 52     Fields:    Translation:Cells
    193. Fritz CC, Zapp ML, Green MR. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature. 1995 Aug 10; 376(6540):530-3. PMID: 7637788.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    194. Gaur RK, Valcárcel J, Green MR. Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein. RNA. 1995 Jun; 1(4):407-17. PMID: 7493318.
      Citations: 26     Fields:    Translation:Cells
    195. Singh R, Valcárcel J, Green MR. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science. 1995 May 26; 268(5214):1173-6. PMID: 7761834.
      Citations: 268     Fields:    Translation:HumansAnimalsCells
    196. Roberts SG, Choy B, Walker SS, Lin YS, Green MR. A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation. Curr Biol. 1995 May 01; 5(5):508-16. PMID: 7583100.
      Citations: 27     Fields:    Translation:Cells
    197. Southgate CD, Green MR. Delineating minimal protein domains and promoter elements for transcriptional activation by lentivirus Tat proteins. J Virol. 1995 Apr; 69(4):2605-10. PMID: 7884911.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    198. Kwon H, Green MR. The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein. J Biol Chem. 1994 Dec 02; 269(48):30140-6. PMID: 7982918.
      Citations: 23     Fields:    Translation:HumansCells
    199. Zhang G, Taneja KL, Singer RH, Green MR. Localization of pre-mRNA splicing in mammalian nuclei. Nature. 1994 Dec 22-29; 372(6508):809-12. PMID: 7997273.
      Citations: 104     Fields:    Translation:HumansCells
    200. Roberts SG, Green MR. Activator-induced conformational change in general transcription factor TFIIB. Nature. 1994 Oct 20; 371(6499):717-20. PMID: 7935820.
      Citations: 66     Fields:    Translation:Cells
    201. Reese JC, Apone L, Walker SS, Griffin LA, Green MR. Yeast TAFIIS in a multisubunit complex required for activated transcription. Nature. 1994 Oct 06; 371(6497):523-7. PMID: 7935765.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    202. Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR. Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex. Nature. 1994 Aug 11; 370(6489):477-81. PMID: 8047169.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    Green's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (860)
    Co-Authors (32)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors