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Juleen Zierath to Humans

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This is a "connection" page, showing publications Juleen Zierath has written about Humans.
Juleen Zierath
Connection Strength
1.571
Humans
  1. Katayama M, Nomura K, Mudry JM, Chibalin AV, Krook A, Zierath JR. Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle. Mol Metab. 2025 Feb; 92:102081.
    View in: PubMed
    Score: 0.037
  2. Zierath JR, van der Velden J, Javaheri A, Rosenzweig A, Muoio DM, Mulvihill EE, Martino TA, Rasheed A, Chen XW, Arany ZP. Translating metabolic and cardiovascular research into effective treatments: What's next? Cell. 2024 Jul 25; 187(15):3880-3884.
    View in: PubMed
    Score: 0.036
  3. Jollet M, Tramontana F, Jiang LQ, Borg ML, Savikj M, Kuefner MS, Massart J, de Castro Barbosa T, Manner?s-Holm L, Checa A, Pillon NJ, Chibalin AV, Bj?rnholm M, Zierath JR. Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity. Metabolism. 2024 Sep; 158:155939.
    View in: PubMed
    Score: 0.036
  4. Richter EA, James DE, Kirwan JP, Zierath JR. Exploratory physiological experiments are not clinical trials. Cell Metab. 2024 May 07; 36(5):882-883.
    View in: PubMed
    Score: 0.036
  5. Ashcroft SP, Stocks B, Egan B, Zierath JR. Exercise induces tissue-specific adaptations to enhance cardiometabolic health. Cell Metab. 2024 02 06; 36(2):278-300.
    View in: PubMed
    Score: 0.035
  6. Pillon NJ, Sard?n Puig L, Altintas A, Kamble PG, Casan?-Gald?n S, Gabriel BM, Barr?s R, Conesa A, Chibalin AV, N?slund E, Krook A, Zierath JR. Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers. Life Sci Alliance. 2023 01; 6(1).
    View in: PubMed
    Score: 0.032
  7. Pillon NJ, Smith JAB, Alm PS, Chibalin AV, Alhusen J, Arner E, Carninci P, Fritz T, Otten J, Olsson T, van Doorslaer de Ten Ryen S, Deldicque L, Caidahl K, Wallberg-Henriksson H, Krook A, Zierath JR. Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. Sci Adv. 2022 09 09; 8(36):eabo3192.
    View in: PubMed
    Score: 0.032
  8. Stocks B, Zierath JR. Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity. Endocr Rev. 2022 07 13; 43(4):654-677.
    View in: PubMed
    Score: 0.031
  9. Kanaley JA, Colberg SR, Corcoran MH, Malin SK, Rodriguez NR, Crespo CJ, Kirwan JP, Zierath JR. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2022 02 01; 54(2):353-368.
    View in: PubMed
    Score: 0.031
  10. Sj?gren RJO, Rizo-Roca D, Chibalin AV, Chorell E, Furrer R, Katayama S, Harada J, Karlsson HKR, Handschin C, Moritz T, Krook A, N?slund E, Zierath JR. Branched-chain amino acid metabolism is regulated by ERRa in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia. 2021 09; 64(9):2077-2091.
    View in: PubMed
    Score: 0.029
  11. Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell. 2021 03 18; 184(6):1530-1544.
    View in: PubMed
    Score: 0.029
  12. Karlsson HKR, Kasahara A, Ikeda M, Chibalin AV, Harada J, Ryd?n M, Krook A, Kato M, Kubota K, Zierath JR. Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study. Metabolism. 2021 05; 118:154726.
    View in: PubMed
    Score: 0.029
  13. Hawley JA, Sassone-Corsi P, Zierath JR. Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men. Diabetologia. 2020 11; 63(11):2253-2259.
    View in: PubMed
    Score: 0.028
  14. Savikj M, Zierath JR. Train like an athlete: applying exercise interventions to manage type 2 diabetes. Diabetologia. 2020 08; 63(8):1491-1499.
    View in: PubMed
    Score: 0.027
  15. Pillon NJ, Gabriel BM, Dollet L, Smith JAB, Sard?n Puig L, Botella J, Bishop DJ, Krook A, Zierath JR. Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity. Nat Commun. 2020 01 24; 11(1):470.
    View in: PubMed
    Score: 0.027
  16. Zierath JR. Major Advances and Discoveries in Diabetes - 2019 in Review. Curr Diab Rep. 2019 11 04; 19(11):118.
    View in: PubMed
    Score: 0.026
  17. Sardon Puig L, Pillon NJ, N?slund E, Krook A, Zierath JR. Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression. Am J Physiol Endocrinol Metab. 2020 01 01; 318(1):E1-E10.
    View in: PubMed
    Score: 0.026
  18. Massart J, Zierath JR. Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis. Trends Endocrinol Metab. 2019 09; 30(9):603-617.
    View in: PubMed
    Score: 0.026
  19. Borg ML, Massart J, Sch?nke M, De Castro Barbosa T, Guo L, Wade M, Alsina-Fernandez J, Miles R, Ryan A, Bauer S, Coskun T, O'Farrell E, Niemeier EM, Chibalin AV, Krook A, Karlsson HK, Brozinick JT, Zierath JR. Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice. Diabetes. 2019 07; 68(7):1403-1414.
    View in: PubMed
    Score: 0.025
  20. Gabriel BM, Zierath JR. Circadian rhythms and exercise - re-setting the clock in metabolic disease. Nat Rev Endocrinol. 2019 04; 15(4):197-206.
    View in: PubMed
    Score: 0.025
  21. Dollet L, Zierath JR. Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue. J Physiol. 2019 03; 597(6):1439-1450.
    View in: PubMed
    Score: 0.025
  22. Lassiter DG, Sj?gren RJO, Gabriel BM, Krook A, Zierath JR. AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle. Mol Metab. 2018 10; 16:12-23.
    View in: PubMed
    Score: 0.024
  23. Lassiter DG, Nyl?n C, Sj?gren RJO, Chibalin AV, Wallberg-Henriksson H, N?slund E, Krook A, Zierath JR. FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle. Diabetologia. 2018 02; 61(2):424-432.
    View in: PubMed
    Score: 0.023
  24. Ruby MA, Riedl I, Massart J, ?hlin M, Zierath JR. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017 10 01; 313(4):E483-E491.
    View in: PubMed
    Score: 0.022
  25. Gabriel BM, Zierath JR. The Limits of Exercise Physiology: From Performance to Health. Cell Metab. 2017 May 02; 25(5):1000-1011.
    View in: PubMed
    Score: 0.022
  26. Ruby MA, Massart J, Hunerdosse DM, Sch?nke M, Correia JC, Louie SM, Ruas JL, N?slund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017 01 17; 18(3):636-646.
    View in: PubMed
    Score: 0.022
  27. Mudry JM, Lassiter DG, Nyl?n C, Garc?a-Calz?n S, N?slund E, Krook A, Zierath JR. Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle. Diabetes. 2017 03; 66(3):651-662.
    View in: PubMed
    Score: 0.021
  28. Egan B, Hawley JA, Zierath JR. SnapShot: Exercise Metabolism. Cell Metab. 2016 08 09; 24(2):342-342.e1.
    View in: PubMed
    Score: 0.021
  29. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 06 14; 23(6):1034-1047.
    View in: PubMed
    Score: 0.021
  30. Zierath JR. Turning the page. Diabetologia. 2015 Dec; 58(12):2685-7.
    View in: PubMed
    Score: 0.020
  31. Zierath JR. Diabetologia at 50: celebrating half a century of progress in diabetes research and care. Diabetologia. 2015 Aug; 58(8):1685-7.
    View in: PubMed
    Score: 0.019
  32. Zierath JR, Wallberg-Henriksson H. Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us? Cell Metab. 2015 Jul 07; 22(1):25-30.
    View in: PubMed
    Score: 0.019
  33. Hawley JA, Hargreaves M, Joyner MJ, Zierath JR. Integrative biology of exercise. Cell. 2014 Nov 06; 159(4):738-49.
    View in: PubMed
    Score: 0.018
  34. Al-Khalili L, de Castro Barbosa T, Ostling J, Massart J, Cuesta PG, Osler ME, Katayama M, Nystr?m AC, Oscarsson J, Zierath JR. Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C774-87.
    View in: PubMed
    Score: 0.018
  35. Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1408-14.
    View in: PubMed
    Score: 0.017
  36. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, N?slund E, Zierath JR. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013 Apr 25; 3(4):1020-7.
    View in: PubMed
    Score: 0.017
  37. Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013 Feb 05; 17(2):162-84.
    View in: PubMed
    Score: 0.016
  38. Mashili F, Chibalin AV, Krook A, Zierath JR. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013 Feb; 62(2):457-65.
    View in: PubMed
    Score: 0.016
  39. Barr?s R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012 Mar 07; 15(3):405-11.
    View in: PubMed
    Score: 0.015
  40. Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem. 2011 Oct 07; 286(40):34567-74.
    View in: PubMed
    Score: 0.015
  41. Barr?s R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 2009 Sep; 10(3):189-98.
    View in: PubMed
    Score: 0.013
  42. Wallberg-Henriksson H, Zierath JR. A new twist on brown fat metabolism. Cell. 2009 Apr 03; 137(1):22-4.
    View in: PubMed
    Score: 0.013
  43. Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes. 2008 Jun; 57(6):1508-16.
    View in: PubMed
    Score: 0.012
  44. Chibalin AV, Leng Y, Vieira E, Krook A, Bj?rnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nyl?n C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell. 2008 Feb 08; 132(3):375-86.
    View in: PubMed
    Score: 0.012
  45. Zierath JR. The path to insulin resistance: paved with ceramides? Cell Metab. 2007 Mar; 5(3):161-3.
    View in: PubMed
    Score: 0.011
  46. Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem. 2007 Mar 16; 282(11):7783-9.
    View in: PubMed
    Score: 0.011
  47. Karlsson HK, Zierath JR. Insulin signaling and glucose transport in insulin resistant human skeletal muscle. Cell Biochem Biophys. 2007; 48(2-3):103-13.
    View in: PubMed
    Score: 0.011
  48. Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 2006 Jul; 4(1):89-96.
    View in: PubMed
    Score: 0.010
  49. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006 Jul; 116(7):1776-83.
    View in: PubMed
    Score: 0.010
  50. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes. 2006 Jun; 55(6):1776-82.
    View in: PubMed
    Score: 0.010
  51. Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR. IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients. Diabetes. 2006 Mar; 55(3):785-91.
    View in: PubMed
    Score: 0.010
  52. Karlsson HK, H?llsten K, Bj?rnholm M, Tsuchida H, Chibalin AV, Virtanen KA, Heinonen OJ, L?nnqvist F, Nuutila P, Zierath JR. Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes. 2005 May; 54(5):1459-67.
    View in: PubMed
    Score: 0.010
  53. Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev. 2005 May; 1(2):167-74.
    View in: PubMed
    Score: 0.010
  54. Zierath JR. Kinases in diabetes. Part I. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):118-20.
    View in: PubMed
    Score: 0.009
  55. Zierath JR. Kinases in diabetes. Part II. 11-12 November 2004, Manchester, UK. IDrugs. 2005 Feb; 8(2):121-3.
    View in: PubMed
    Score: 0.009
  56. Stocks B, Quesada JP, Mozzicato AM, Jacob C, Jensen S, MacGregor KA, Bangsbo J, Zierath JR, Hostrup M, Deshmukh AS. Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise. Sci Adv. 2025 Jan 31; 11(5):eadp8608.
    View in: PubMed
    Score: 0.009
  57. Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 Oct; 2(10):e348.
    View in: PubMed
    Score: 0.009
  58. Rizo-Roca D, Guimar?es DSPSF, Pendergrast LA, Di Leo N, Chibalin AV, Maqdasy S, Ryd?n M, N?slund E, Zierath JR, Krook A. Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes. Sci Transl Med. 2024 Oct 09; 16(768):eado3022.
    View in: PubMed
    Score: 0.009
  59. Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine LM, Higos R, Jalkanen J, Zhong J, Zareifi DS, Frendo-Cumbo S, Massier L, Hodek O, Juvany M, Moritz T, de Castro Barbosa T, Omar-Hmeadi M, L?pez-Yus M, Merabtene F, Abatan JB, Marcelin G, El Hachem EJ, Rouault C, Bergo MO, Petrus P, Zierath JR, Cl?ment K, Krook A, Mejhert N, Ryd?n M. Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Nat Metab. 2024 Jul; 6(7):1329-1346.
    View in: PubMed
    Score: 0.009
  60. Krook A, Wallberg-Henriksson H, Zierath JR. Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc. 2004 Jul; 36(7):1212-7.
    View in: PubMed
    Score: 0.009
  61. Nomura K, Kinoshita S, Mizusaki N, Senga Y, Sasaki T, Kitamura T, Sakaue H, Emi A, Hosooka T, Matsuo M, Okamura H, Amo T, Wolf AM, Kamimura N, Ohta S, Itoh T, Hayashi Y, Kiyonari H, Krook A, Zierath JR, Kasuga M, Ogawa W. Adaptive gene expression of alternative splicing variants of PGC-1a regulates whole-body energy metabolism. Mol Metab. 2024 Aug; 86:101968.
    View in: PubMed
    Score: 0.009
  62. Leng Y, Karlsson HK, Zierath JR. Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord. 2004 May; 5(2):111-7.
    View in: PubMed
    Score: 0.009
  63. Long YC, Widegren U, Zierath JR. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc. 2004 May; 63(2):227-32.
    View in: PubMed
    Score: 0.009
  64. Guimar?es DSPSF, Barrios NMF, de Oliveira AG, Rizo-Roca D, Jollet M, Smith JAB, Araujo TR, da Cruz MV, Marconato E, Hirabara SM, Vieira AS, Krook A, Zierath JR, Silveira LR. Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6. J Cachexia Sarcopenia Muscle. 2024 Aug; 15(4):1335-1347.
    View in: PubMed
    Score: 0.009
  65. Koistinen HA, Forsgren M, Wallberg-Henriksson H, Zierath JR. Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects. Obes Res. 2004 Jan; 12(1):25-31.
    View in: PubMed
    Score: 0.009
  66. Dollet L, Lundell LS, Chibalin AV, Pendergrast LA, Pillon NJ, Lansbury EL, Elmastas M, Frendo-Cumbo S, Jalkanen J, de Castro Barbosa T, Cervone DT, Caidahl K, Dmytriyeva O, Deshmukh AS, Barr?s R, Ryd?n M, Wallberg-Henriksson H, Zierath JR, Krook A. Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M. Cell Rep Med. 2024 01 16; 5(1):101348.
    View in: PubMed
    Score: 0.009
  67. Zierath JR, Kawano Y. The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle. Best Pract Res Clin Endocrinol Metab. 2003 Sep; 17(3):385-98.
    View in: PubMed
    Score: 0.009
  68. Kemppainen J, Tsuchida H, Stolen K, Karlsson H, Bj?rnholm M, Heinonen OJ, Nuutila P, Krook A, Knuuti J, Zierath JR. Insulin signalling and resistance in patients with chronic heart failure. J Physiol. 2003 Jul 01; 550(Pt 1):305-15.
    View in: PubMed
    Score: 0.008
  69. Yu M, Stepto NK, Chibalin AV, Fryer LG, Carling D, Krook A, Hawley JA, Zierath JR. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol. 2003 Jan 15; 546(Pt 2):327-35.
    View in: PubMed
    Score: 0.008
  70. Zierath JR. Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol (1985). 2002 Aug; 93(2):773-81.
    View in: PubMed
    Score: 0.008
  71. Savikj M, Stocks B, Sato S, Caidahl K, Krook A, Deshmukh AS, Zierath JR, Wallberg-Henriksson H. Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial. Metabolism. 2022 10; 135:155268.
    View in: PubMed
    Score: 0.008
  72. Zierath JR, Wallberg-Henriksson H. From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients. Ann N Y Acad Sci. 2002 Jun; 967:120-34.
    View in: PubMed
    Score: 0.008
  73. Dollet L, Kuefner M, Caria E, Rizo-Roca D, Pendergrast L, Abdelmoez AM, Karlsson HKR, Bj?rnholm M, Dalbram E, Treebak JT, Harada J, N?slund E, Ryd?n M, Zierath JR, Pillon NJ, Krook A. Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes. Diabetes. 2022 04 01; 71(4):624-636.
    View in: PubMed
    Score: 0.008
  74. Maqdasy S, Lecoutre S, Renzi G, Frendo-Cumbo S, Rizo-Roca D, Moritz T, Juvany M, Hodek O, Gao H, Couchet M, Witting M, Kerr A, Bergo MO, Choudhury RP, Aouadi M, Zierath JR, Krook A, Mejhert N, Ryd?n M. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nat Metab. 2022 02; 4(2):190-202.
    View in: PubMed
    Score: 0.008
  75. Small L, Ehrlich A, Iversen J, Ashcroft SP, Tro?t K, Moritz T, Hartmann B, Holst JJ, Treebak JT, Zierath JR, Barr?s R. Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice. Mol Metab. 2022 03; 57:101440.
    View in: PubMed
    Score: 0.008
  76. Massart J, Sj?gren RJO, Egan B, Garde C, Lindgren M, Gu W, Ferreira DMS, Katayama M, Ruas JL, Barr?s R, O'Gorman DJ, Zierath JR, Krook A. Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism. Nat Commun. 2021 10 12; 12(1):5948.
    View in: PubMed
    Score: 0.007
  77. Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Bj?rnholm M, J?rgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS. Discovery of thymosin ?4 as a human exerkine and growth factor. Am J Physiol Cell Physiol. 2021 11 01; 321(5):C770-C778.
    View in: PubMed
    Score: 0.007
  78. Williams K, Carrasquilla GD, Ingerslev LR, Hochreuter MY, Hansson S, Pillon NJ, Donkin I, Versteyhe S, Zierath JR, Kilpel?inen TO, Barr?s R. Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health. Mol Metab. 2021 11; 53:101290.
    View in: PubMed
    Score: 0.007
  79. Smith JAB, Savikj M, Sethi P, Platt S, Gabriel BM, Hawley JA, Dunstan D, Krook A, Zierath JR, N?slund E. Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity. Am J Physiol Endocrinol Metab. 2021 08 01; 321(2):E203-E216.
    View in: PubMed
    Score: 0.007
  80. Gonzalez-Franquesa A, Stocks B, Chubanava S, Hattel HB, Moreno-Justicia R, Peijs L, Treebak JT, Zierath JR, Deshmukh AS. Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity. Cell Rep. 2021 05 25; 35(8):109180.
    View in: PubMed
    Score: 0.007
  81. Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Altintas A, Sato S, Sassone-Corsi P, Barr?s R, Zierath JR, Hawley JA. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020 09 16; 11(1):4643.
    View in: PubMed
    Score: 0.007
  82. Batista TM, Jayavelu AK, Wewer Albrechtsen NJ, Iovino S, Lebastchi J, Pan H, Dreyfuss JM, Krook A, Zierath JR, Mann M, Kahn CR. A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes. Cell Metab. 2020 11 03; 32(5):844-859.e5.
    View in: PubMed
    Score: 0.007
  83. Abdelmoez AM, Sard?n Puig L, Smith JAB, Gabriel BM, Savikj M, Dollet L, Chibalin AV, Krook A, Zierath JR, Pillon NJ. Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism. Am J Physiol Cell Physiol. 2020 03 01; 318(3):C615-C626.
    View in: PubMed
    Score: 0.007
  84. Katayama M, Wiklander OPB, Fritz T, Caidahl K, El-Andaloussi S, Zierath JR, Krook A. Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle. Diabetes. 2019 03; 68(3):515-526.
    View in: PubMed
    Score: 0.006
  85. Nyl?n C, Lundell LS, Massart J, Zierath JR, N?slund E. Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E178-E185.
    View in: PubMed
    Score: 0.006
  86. Savikj M, Gabriel BM, Alm PS, Smith J, Caidahl K, Bj?rnholm M, Fritz T, Krook A, Zierath JR, Wallberg-Henriksson H. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia. 2019 02; 62(2):233-237.
    View in: PubMed
    Score: 0.006
  87. Massart J, Sj?gren RJO, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A. Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. Diabetes. 2017 07; 66(7):1807-1818.
    View in: PubMed
    Score: 0.005
  88. Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sj?gren RJ, N?slund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O'Rahilly S, Wareham NJ, Langenberg C. Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. PLoS Med. 2016 Nov; 13(11):e1002179.
    View in: PubMed
    Score: 0.005
  89. Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev. 2016 10; 32(7):754-761.
    View in: PubMed
    Score: 0.005
  90. Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, J?rgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barr?s R. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metab. 2016 Feb 09; 23(2):369-78.
    View in: PubMed
    Score: 0.005
  91. Cedernaes J, Osler ME, Voisin S, Broman JE, Vogel H, Dickson SL, Zierath JR, Schi?th HB, Benedict C. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men. J Clin Endocrinol Metab. 2015 Sep; 100(9):E1255-61.
    View in: PubMed
    Score: 0.005
  92. Ring M, Eriksson MJ, Fritz T, Nyberg G, ?stenson CG, Krook A, Zierath JR, Caidahl K. Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance. Diab Vasc Dis Res. 2015 Sep; 12(5):315-24.
    View in: PubMed
    Score: 0.005
  93. Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015 Jun; 38(6):1154-60.
    View in: PubMed
    Score: 0.005
  94. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, N?slund E, Zierath JR, Wong GW, Feinberg AP. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015 Jan 06; 21(1):138-49.
    View in: PubMed
    Score: 0.005
  95. Sj?gren RJ, Egan B, Katayama M, Zierath JR, Krook A. Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells. Physiol Genomics. 2015 Mar; 47(3):45-57.
    View in: PubMed
    Score: 0.005
  96. Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV. Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 2015 Feb; 64(2):360-9.
    View in: PubMed
    Score: 0.005
  97. Agudelo LZ, Femen?a T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL. Skeletal muscle PGC-1a1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014 Sep 25; 159(1):33-45.
    View in: PubMed
    Score: 0.005
  98. Ring M, Eriksson MJ, Zierath JR, Caidahl K. Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques. Hypertens Res. 2014 Nov; 37(11):999-1007.
    View in: PubMed
    Score: 0.005
  99. Moltke I, Grarup N, J?rgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature. 2014 Aug 14; 512(7513):190-3.
    View in: PubMed
    Score: 0.005
  100. Rasmussen M, Zierath JR, Barr?s R. Dynamic epigenetic responses to muscle contraction. Drug Discov Today. 2014 Jul; 19(7):1010-4.
    View in: PubMed
    Score: 0.004
  101. Kirchner H, Nylen C, Laber S, Barr?s R, Yan J, Krook A, Zierath JR, N?slund E. Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis. 2014 Jul-Aug; 10(4):671-8.
    View in: PubMed
    Score: 0.004
  102. Jiang LQ, Franck N, Egan B, Sj?gren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR, Krook A. Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab. 2013 Dec 01; 305(11):E1359-66.
    View in: PubMed
    Score: 0.004
  103. Egan B, O'Connor PL, Zierath JR, O'Gorman DJ. Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One. 2013; 8(9):e74098.
    View in: PubMed
    Score: 0.004
  104. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Fr?sig C, Leick L, Fentz J, J?rgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20.
    View in: PubMed
    Score: 0.004
  105. Russell AP, Lamon S, Boon H, Wada S, G?ller I, Brown EL, Chibalin AV, Zierath JR, Snow RJ, Stepto N, Wadley GD, Akimoto T. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol. 2013 Sep 15; 591(18):4637-53.
    View in: PubMed
    Score: 0.004
  106. Jiang LQ, Duque-Guimaraes DE, Machado UF, Zierath JR, Krook A. Altered response of skeletal muscle to IL-6 in type 2 diabetic patients. Diabetes. 2013 Feb; 62(2):355-61.
    View in: PubMed
    Score: 0.004
  107. Yan J, Zierath JR, Barr?s R. Evidence for non-CpG methylation in mammals. Exp Cell Res. 2011 Nov 01; 317(18):2555-61.
    View in: PubMed
    Score: 0.004
  108. Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME. Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism. 2012 Feb; 61(2):175-85.
    View in: PubMed
    Score: 0.004
  109. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev. 2011 Mar; 27(3):286-97.
    View in: PubMed
    Score: 0.004
  110. Egan B, Dowling P, O'Connor PL, Henry M, Meleady P, Zierath JR, O'Gorman DJ. 2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training. Proteomics. 2011 Apr; 11(8):1413-28.
    View in: PubMed
    Score: 0.004
  111. Feng X, Yan J, Wang Y, Zierath JR, Nordenskj?ld M, Henter JI, Fadeel B, Zheng C. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol. 2010 Aug; 47(14):2388-96.
    View in: PubMed
    Score: 0.003
  112. Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010 May 15; 588(Pt 10):1779-90.
    View in: PubMed
    Score: 0.003
  113. Benziane B, Bj?rnholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1554-66.
    View in: PubMed
    Score: 0.003
  114. Karlsson HK, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD. Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes. 2009 Apr; 58(4):847-54.
    View in: PubMed
    Score: 0.003
  115. Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK. Divergent cell signaling after short-term intensified endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1427-38.
    View in: PubMed
    Score: 0.003
  116. Cabrera O, Jacques-Silva MC, Speier S, Yang SN, K?hler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metab. 2008 Jun; 7(6):545-54.
    View in: PubMed
    Score: 0.003
  117. Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes. 2008 Aug; 57(8):2066-73.
    View in: PubMed
    Score: 0.003
  118. Glund S, Deshmukh A, Long YC, Moller T, Koistinen HA, Caidahl K, Zierath JR, Krook A. Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes. 2007 Jun; 56(6):1630-7.
    View in: PubMed
    Score: 0.003
  119. Fritz T, Kr?mer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A. Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev. 2006 Nov-Dec; 22(6):492-8.
    View in: PubMed
    Score: 0.003
  120. Karlsson HK, Ahls?n M, Zierath JR, Wallberg-Henriksson H, Koistinen HA. Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes. 2006 May; 55(5):1283-8.
    View in: PubMed
    Score: 0.003
  121. Coffey VG, Zhong Z, Shield A, Canny BJ, Chibalin AV, Zierath JR, Hawley JA. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J. 2006 Jan; 20(1):190-2.
    View in: PubMed
    Score: 0.002
  122. Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK. Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes. 2005 Oct; 54(10):2939-45.
    View in: PubMed
    Score: 0.002
  123. Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palac?n M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes. 2005 Sep; 54(9):2685-93.
    View in: PubMed
    Score: 0.002
  124. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun; 54(6):1692-7.
    View in: PubMed
    Score: 0.002
  125. Kr?mer DK, Al-Khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, Wallberg-Henriksson H, Ehrenborg E, Zierath JR, Krook A. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005 Apr; 54(4):1157-63.
    View in: PubMed
    Score: 0.002
  126. Al-Khalili L, Krook A, Zierath JR, Cartee GD. Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake. Am J Physiol Endocrinol Metab. 2004 Sep; 287(3):E553-7.
    View in: PubMed
    Score: 0.002
  127. Karlsson HK, Nilsson PA, Nilsson J, Chibalin AV, Zierath JR, Blomstrand E. Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E1-7.
    View in: PubMed
    Score: 0.002
  128. Storgaard H, Jensen CB, Bj?rnholm M, Song XM, Madsbad S, Zierath JR, Vaag AA. Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab. 2004 Mar; 89(3):1301-11.
    View in: PubMed
    Score: 0.002
  129. Al-Khalili L, Chibalin AV, Yu M, Sj?din B, Nyl?n C, Zierath JR, Krook A. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol. 2004 Jun; 286(6):C1410-6.
    View in: PubMed
    Score: 0.002
  130. Perrini S, Henriksson J, Zierath JR, Widegren U. Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle. Diabetes. 2004 Jan; 53(1):21-4.
    View in: PubMed
    Score: 0.002
  131. Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes. 2003 May; 52(5):1066-72.
    View in: PubMed
    Score: 0.002
  132. Isaksson B, Str?mmer L, Friess H, B?chler MW, Herrington MK, Wang F, Zierath JR, Wallberg-Henriksson H, Larsson J, Permert J. Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients. Pancreas. 2003 Mar; 26(2):173-7.
    View in: PubMed
    Score: 0.002
  133. Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR, Rabasa-Lhoret R, Wallberg-Henriksson H, Laville M, Palac?n M, Vidal H, Rivera F, Brand M, Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem. 2003 May 09; 278(19):17190-7.
    View in: PubMed
    Score: 0.002
  134. Tsuchida H, Bj?rnholm M, Fernstr?m M, Galuska D, Johansson P, Wallberg-Henriksson H, Zierath JR, Lake S, Krook A. Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects. Pflugers Arch. 2002 Oct; 445(1):25-31.
    View in: PubMed
    Score: 0.002
  135. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J. 2002 Aug; 16(10):1163-76.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.