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Nils Henninger MD, PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Email
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentPsychiatry

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Johannes Gutenberg University, Mainz, , GermanyMD
    University of Massachusetts Medical School, Worcester, MA, United StatesPHDBiomedical Sciences
    Johannes Gutenberg University, Mainz, GermanyDr. med.12/2002Medicine
    Ruprecht-Karls-University Heidelberg, Heidelberg, Germany07/2004Resident in Neurology
    University of Massachusetts Medical School, Worcester, MA06/2011Resident in Neurology
    Harvard Medical School, Boston, MA06/2012Clinical Fellow in Neurology
    Collapse awards and honors
    Alpha Omega Alpha
    2016 - 2021K08 NS091499, NINDS of the NIH
    2018 - 2019Riccio Neuroscience Fund, UMass

    Collapse Overview 
    Collapse overview

    Biography

    Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

    Research Program

    As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. The overarching goal of my research is to define mechanisms driving white matter damage and its contribution to functional outcome after brain injury.

    My main basic science research is aimed at understanding the molecular mechanisms underlying axonal degeneration in the brain after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.

    My main clinical research interest is focused on investigating chronic ischemic white matter injury in the brain termed leukoaraiosis and how it impacts outcome after ischemic stroke. Leukoaraiosis is common among patients with stroke as it shares common risk factors with stroke and has been linked to cognitive and neurological decline as well as increased stroke risk. Results from my research have highlighted that stroke patients with severe pre-existing leukoaraiosis have larger strokes, worse functional deficits at presentation, recovery to a lesser extent, and have an overall greater risk for functional dependence after their stroke as compared to patients with only mild leukoaraiosis.

    Positions

    --We accept residents and fellows year round to work on mentored clinical research projects.

    --There are presently no vacancies in our lab.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. J Stroke Cerebrovasc Dis. 2020 Nov 06; 30(1):105380. PMID: 33166769.
      View in: PubMed
    2. Zhou E, Lord A, Boehme A, Henninger N, de Havenon A, Vahidy F, Ishida K, Torres J, Mistry EA, Mac Grory B, Sheth KN, Gurol ME, Furie K, Elkind MSV, Yaghi S. Risk of Ischemic Stroke in Patients With Atrial Fibrillation After Extracranial Hemorrhage. Stroke. 2020 Oct 08; STROKEAHA120029959. PMID: 33028172.
      View in: PubMed
    3. Jun-O'Connell AH, Jayaraman DK, Henninger N, Silver B, Moonis M, Rothschild AJ. Effects of Preexisting Psychotropic Medication Use on a Cohort of Patients with Ischemic Stroke Outcome. Stroke Res Treat. 2020; 2020:9070486. PMID: 33029341.
      View in: PubMed
    4. Miller MM, Dakay K, Henninger N, Mayasi Y, Mahta A, Yakhkind A, Hannoun A, Thompson BB, Wendell LC, Carandang R. Association of Dexamethasone with Shunt Requirement, Early Disability, and Medical Complications in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2020 Aug 26. PMID: 32851604.
      View in: PubMed
    5. Kvernland A, Kumar A, Yaghi S, Raz E, Frontera J, Lewis A, Czeisler B, Kahn DE, Zhou T, Ishida K, Torres J, Riina HA, Shapiro M, Nossek E, Nelson PK, Tanweer O, Gordon D, Jain R, Dehkharghani S, Henninger N, de Havenon A, Grory BM, Lord A, Melmed K. Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System. Neurocrit Care. 2020 Aug 24. PMID: 32839867.
      View in: PubMed
    6. Yaghi S, Mistry E, Liberman AL, Giles J, Asad SD, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Lord A, Furie K, Keyrouz S, Nouh A, Leon Guerrero CR, de Havenon A, Khan M, Henninger N. Anticoagulation Type and Early Recurrence in Cardioembolic Stroke: The IAC Study. Stroke. 2020 Aug 06; STROKEAHA120028867. PMID: 32757753.
      View in: PubMed
    7. Yaghi S, Trivedi T, Henninger N, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Grory BM, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Liberman AL, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Leon Guerrero CR, Khan M, Nouh A, Mistry E, Keyrouz S, Furie K. Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk. Ann Neurol. 2020 Jul 12. PMID: 32656768.
      View in: PubMed
    8. Miller MM, Henninger N, Slowik A. Mean platelet volume and its genetic variants relate to stroke severity and one-year mortality. Neurology. 2020 Jun 23. PMID: 32576634.
      View in: PubMed
    9. Yaghi S, Ishida K, Torres J, Mac Grory B, Raz E, Humbert K, Henninger N, Trivedi T, Lillemoe K, Alam S, Sanger M, Kim S, Scher E, Dehkharghani S, Wachs M, Tanweer O, Volpicelli F, Bosworth B, Lord A, Frontera J. SARS2-CoV-2 and Stroke in a New York Healthcare System. Stroke. 2020 May 20; STROKEAHA120030335. PMID: 32432996.
      View in: PubMed
    10. Albo Z, Marino J, Nagy M, Jayaraman DK, Azeem MU, Puri AS, Henninger N. Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke. J Neurointerv Surg. 2020 May 15. PMID: 32414890.
      View in: PubMed
    11. Yaghi S, Henninger N, Scher E, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Liberman AL, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Trivedi T, Leon Guerrero CR, Khan M, Nouh A, Mistry E, Keyrouz S, Furie K. Early ischaemic and haemorrhagic complications after atrial fibrillation-related ischaemic stroke: analysis of the IAC study. J Neurol Neurosurg Psychiatry. 2020 May 13. PMID: 32404380.
      View in: PubMed
    12. Yaghi S, Liberman AL, Henninger N, Grory BM, Nouh A, Scher E, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Fakhri H, Espaillat KB, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Trivedi T, Ishida K, Frontera J, Lord A, Furie K, Keyrouz S, de Havenon A, Mistry E, Leon Guerrero CR, Khan M. Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation. J Stroke Cerebrovasc Dis. 2020 May 12; 104888. PMID: 32414583.
      View in: PubMed
    13. Azeem MU, Nagy M, Miller MM, Ghasemi M, Mikati A, Silver B, Moonis M, Henninger N. Prevalence of a Multiple Territory Stroke Pattern After Intravenous Thrombolysis. J Stroke Cerebrovasc Dis. 2020 Feb 21; 104700. PMID: 32093987.
      View in: PubMed
    14. Silver B, Hamid T, Khan M, DiNapoli M, Behrouz R, Saposnik G, Sarafin JA, Martin S, Moonis M, Henninger N, Goddeau R, Jun-O'Connell A, Cutting SM, Saad A, Yaghi S, Hall W, Muehlschlegel S, Carandang R, Osgood M, Thompson BB, Fehnel CR, Wendell LC, Potter NS, Gilchrist JM, Barton B. 12 versus 24 h bed rest after acute ischemic stroke thrombolysis: a preliminary experience. J Neurol Sci. 2019 Dec 05; 409:116618. PMID: 31837536.
      View in: PubMed
    15. Sun Y, Miller MM, Yaghi S, Silver B, Henninger N. Association of Baseline Cardiac Troponin With Acute Myocardial Infarction in Stroke Patients Presenting Within 4.5 Hours. Stroke. 2019 Dec 04; STROKEAHA119027878. PMID: 31795903.
      View in: PubMed
    16. Henninger N, Kaesmacher J. Mechanical thrombectomy in acute stroke: Paying attention to white matter hyperintensities. Neurology. 2019 Sep 13. PMID: 31519777.
      View in: PubMed
    17. Shazeeb MS, King RM, Brooks OW, Puri AS, Henninger N, Boltze J, Gounis MJ. Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion. Transl Stroke Res. 2019 Sep 03. PMID: 31478129.
      View in: PubMed
    18. Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings JA. Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocrit Care. 2019 Aug 06. PMID: 31388871.
      View in: PubMed
    19. Kühn AL, Kan P, Henninger N, Srinivasan V, de Macedo Rodrigues K, Wakhloo AK, Gounis MJ, Puri AS. Impact of age on cerebral aneurysm occlusion after flow diversion. J Clin Neurosci. 2019 May 06. PMID: 31072739.
      View in: PubMed
    20. Mikati AG, Mandelbaum M, Sapnar S, Puri AS, Silver B, Goddeau RP, Haussen DC, Moonis M, Jun-O'Connell AH, Henninger N. Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke. Transl Stroke Res. 2019 Apr 12. PMID: 30980282.
      View in: PubMed
    21. Khan M, Heiser H, Bernicchi N, Packard L, Parker JL, Edwardson MA, Silver B, Elisevich KV, Henninger N. Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation. J Stroke Cerebrovasc Dis. 2019 Mar 30. PMID: 30940427.
      View in: PubMed
    22. Jun-O'connell AH, Henninger N, Moonis M, Silver B, Ionete C, Goddeau RP. Recrudescence of Old Stroke Deficits Among Transient Neurological Attacks. Neurohospitalist. 2019 Oct; 9(4):183-189. PMID: 31534606.
      View in: PubMed
    23. Miller MM, Lowe J, Khan M, Azeem MU, Muehlschlegel S, Jun-O'Connell AH, Goddeau RP, Moonis M, Gritters D, Silver B, Henninger N. Clinical and Radiological Characteristics of Vitamin K Versus Non-Vitamin K Antagonist Oral Anticoagulation-Related Intracerebral Hemorrhage. Neurocrit Care. 2019 Jan 28. PMID: 30690686.
      View in: PubMed
    24. Henninger N, Mayasi Y. Nucleic Acid Therapies for Ischemic Stroke. Neurotherapeutics. 2019 Jan 11. PMID: 30635869.
      View in: PubMed
    25. Ghasemi M, Azeem MU, Muehlschlegel S, Chu F, Henninger N. Prescription patterns for routine EEG ordering in patients with intracranial hemorrhage admitted to a neurointensive care unit. J Crit Care. 2019 Jan 11; 50:262-268. PMID: 30660914.
      View in: PubMed
    26. Nagy M, Azeem MU, Soliman Y, Nawab SA, Jun-O'Connell AH, Goddeau RP, Moonis M, Silver B, Henninger N. Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack. J Stroke Cerebrovasc Dis. 2019 Jan 07. PMID: 30630754.
      View in: PubMed
    27. Li Y, Fitzgibbons TP, McManus DD, Goddeau RP, Silver B, Henninger N. Left Ventricular Ejection Fraction and Clinically Defined Heart Failure to Predict 90-Day Functional Outcome After Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018 Nov 02. PMID: 30396839.
      View in: PubMed
    28. Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 Sep 04. PMID: 30194041.
      View in: PubMed
    29. Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier. Mol Ther. 2018 Aug 08. PMID: 30143435.
      View in: PubMed
    30. Bouley J, Chung DY, Ayata CY, Brown RH, Henninger N. Cortical spreading depression denotes concussion injury. J Neurotrauma. 2018 Jul 12. PMID: 29999455.
      View in: PubMed
    31. Henninger N, Compton RA, Khan MW, Carandang R, Hall W, Muehlschlegel S. "Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients. J Trauma Acute Care Surg. 2018 Mar; 84(3):473-482. PMID: 29140952.
      View in: PubMed
    32. Kundu A, Day KO, Lessard DM, Gore JM, Lubitz SA, Yu H, Akhter MW, Fisher DZ, Hayward RM, Henninger N, Saczynski JS, Walkey AJ, Kapoor A, Yarzebski J, Goldberg RJ, McManus DD. Recent Trends in Oral Anticoagulant Use and Post-Discharge Complications Among Atrial Fibrillation Patients with Acute Myocardial Infarction. J Atr Fibrillation. 2018 Feb; 10(5):1749. PMID: 29988239.
      View in: PubMed
    33. Aldrugh S, Sardana M, Henninger N, Saczynski JS, McManus DD. Atrial fibrillation, cognition and dementia: A review. J Cardiovasc Electrophysiol. 2017 Jun 01. PMID: 28569383.
      View in: PubMed
    34. Mayasi Y, Helenius J, McManus DD, Goddeau RP, Jun-O'Connell AH, Moonis M, Henninger N. Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke. J Neurol Neurosurg Psychiatry. 2017 May 27. PMID: 28554961.
      View in: PubMed
    35. Minaeian A, Patel A, Essa B, Goddeau RP, Moonis M, Henninger N. Emergency Department Length of Stay and Outcome after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017 May 24. PMID: 28551289.
      View in: PubMed
    36. Bouley J, Henninger N. Lateral ventricle attenuates underlying traumatic axonal injury after closed head injury in the mouse. J Neurotrauma. 2017 Mar 22. PMID: 28325100.
      View in: PubMed
    37. Khan M, Baird GL, Goddeau RP, Silver B, Henninger N. Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion. Front Neurol. 2017; 8:98. PMID: 28352248.
      View in: PubMed
    38. Kongbunkiat K, Wilson D, Kasemsap N, Tiamkao S, Jichi F, Palumbo V, Hill MD, Buchan AM, Jung S, Mattle HP, Henninger N, Werring DJ. Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis. Neurology. 2017 Feb 14; 88(7):638-645. PMID: 28130468.
      View in: PubMed
    39. Meretoja A, Acciarresi M, Akinyemi RO, Campbell B, Dowlatshahi D, English C, Henninger N, Poppe A, Putaala J, Saini M, Sato S, Wu B, Brainin M, Norrving B, Davis S. Stroke doctors: Who are we? A World Stroke Organization survey. Int J Stroke. 2017 Jan 01; 1747493017701150. PMID: 28350278.
      View in: PubMed
    40. Patti J, Helenius J, Puri AS, Henninger N. White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome. Stroke. 2016 Oct; 47(10):2526-33. PMID: 27633020.
      View in: PubMed
    41. Jun-O'Connell AH, Butala A, Morales IB, Henninger N, Deligiannidis KM, Byatt N, Ionete C. The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 2016 Aug 19; appineuropsych15120403. PMID: 27539374.
      View in: PubMed
    42. Khan MA, Baird GL, Miller D, Patel A, Tsekhan S, Yaghi S, Puri A, Jayaraman M, Henninger N, Silver B. Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort. J Neurointerv Surg. 2016 Jul 11. PMID: 27402857.
      View in: PubMed
    43. Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines. Transl Stroke Res. 2016 Aug; 7(4):241-7. PMID: 27297402.
      View in: PubMed
    44. Mayasi Y, Helenius J, Goddeau RP, Moonis M, Henninger N. Time to Presentation Is Associated with Clinical Outcome in Hemispheric Stroke Patients Deemed Ineligible for Recanalization Therapy. J Stroke Cerebrovasc Dis. 2016 Oct; 25(10):2373-9. PMID: 27315744.
      View in: PubMed
    45. Anand Patel, Richard P Goddeau Jr, Nils Henninger. Newer Oral Anticoagulants: Stroke Prevention and Pitfalls. The Open Cardiovascular Medicine Journal. 2016; 10(1):94-104.
    46. Patel A, Goddeau RP, Henninger N. Newer Oral Anticoagulants: Stroke Prevention and Pitfalls. Open Cardiovasc Med J. 2016; 10:94-104. PMID: 27347226.
      View in: PubMed
    47. Henninger N, Goddeau RP, Karmarkar A, Helenius J, McManus DD. Atrial Fibrillation Is Associated With a Worse 90-Day Outcome Than Other Cardioembolic Stroke Subtypes. Stroke. 2016 Jun; 47(6):1486-92. PMID: 27217503.
      View in: PubMed
    48. Massari F, Henninger N, Lozano JD, Patel A, Kuhn AL, Howk M, Perras M, Brooks C, Gounis MJ, Kan P, Wakhloo AK, Puri AS. ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience. Interv Neuroradiol. 2016 Jun; 22(3):325-32. PMID: 26908591.
      View in: PubMed
    49. Henninger N, Bouley J, Sikoglu EM, An J, Moore CM, King JA, Bowser R, Freeman MR, Brown RH. Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1. Brain. 2016 Apr; 139(Pt 4):1094-105. PMID: 26912636.
      View in: PubMed
    50. Henninger N, Fisher M. Extending the Time Window for Endovascular and Pharmacological Reperfusion. Transl Stroke Res. 2016 Aug; 7(4):284-93. PMID: 26739964.
      View in: PubMed
    51. Helenius J, Goddeau RP, Moonis M, Henninger N. Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke. Stroke. 2016 Jan; 47(1):24-30. PMID: 26556825.
      View in: PubMed
    52. Onteddu SR, Goddeau RP, Minaeian A, Henninger N. Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke. J Neurol Sci. 2015 Dec 15; 359(1-2):418-23. PMID: 26476774.
      View in: PubMed
    53. Helenius J, Henninger N. Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke". Stroke. 2015 Aug; 46(8):e197. PMID: 26152295.
      View in: PubMed
    54. Turetsky A, Goddeau RP, Henninger N. Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke. J Stroke Cerebrovasc Dis. 2015 Jul; 24(7):1555-63. PMID: 26009498.
      View in: PubMed
    55. Helenius J, Henninger N. Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke. Stroke. 2015 Jul; 46(7):1857-63. PMID: 25999386.
      View in: PubMed
    56. Mayasi Y, Leidy J, Henninger N. Traumatic atrial myxoma rupture mimicking post-concussive symptoms. Acta Neurol Belg. 2015 Dec; 115(4):737-9. PMID: 25828837.
      View in: PubMed
    57. Osgood M, Budman E, Carandang R, Goddeau RP, Henninger N. Prevalence of Pelvic Vein Pathology in Patients with Cryptogenic Stroke and Patent Foramen Ovale Undergoing MRV Pelvis. Cerebrovasc Dis. 2015; 39(3-4):216-23. PMID: 25791718.
      View in: PubMed
    58. Henninger N, Izzy S, Carandang R, Hall W, Muehlschlegel S. Severe leukoaraiosis portends a poor outcome after traumatic brain injury. Neurocrit Care. 2014 Dec; 21(3):483-95. PMID: 24752459.
      View in: PubMed
    59. Moonis M, Kumar R, Henninger N, Kane K, Fisher M. Pre and Post-stroke Use of Statins Improves Stroke Outcome. Indian J Community Med. 2014 Oct; 39(4):214-7. PMID: 25364144.
      View in: PubMed
    60. Zhang J, Puri AS, Khan MA, Goddeau RP, Henninger N. Leukoaraiosis predicts a poor 90-day outcome after endovascular stroke therapy. AJNR Am J Neuroradiol. 2014 Nov-Dec; 35(11):2070-5. PMID: 24994827.
      View in: PubMed
    61. Khan M, Goddeau RP, Zhang J, Moonis M, Henninger N. Predictors of Outcome following Stroke due to Isolated M2 Occlusions. Cerebrovasc Dis Extra. 2014 Jan; 4(1):52-60. PMID: 24715898.
      View in: PubMed
    62. Henninger N, Khan MA, Zhang J, Moonis M, Goddeau RP. Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion. Stroke. 2014 Mar; 45(3):689-95. PMID: 24523039.
      View in: PubMed
    63. Marinescu M, Bouley J, Chueh J, Fisher M, Henninger N. Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations. J Cereb Blood Flow Metab. 2014 Apr; 34(4):677-82. PMID: 24424380.
      View in: PubMed
    64. Henninger N, Haussen DC, Kakouros N, Selim M, Searls DE, Kumar S, Schlaug G, Caplan LR. QTc-prolongation in posterior circulation stroke. Neurocrit Care. 2013 Oct; 19(2):167-75. PMID: 23860666.
      View in: PubMed
    65. Henninger N, Lin E, Haussen DC, Lehman LL, Takhtani D, Selim M, Moonis M. Leukoaraiosis and sex predict the hyperacute ischemic core volume. Stroke. 2013 Jan; 44(1):61-7. PMID: 23233384.
      View in: PubMed
    66. Krishnan V, Searls DE, Haussen DC, Henninger N, Thomas A. Venous ischemia secondary to drainage constriction in a carotid-cavernous arteriovenous fistula. Clin Neurol Neurosurg. 2013 Aug; 115(8):1476-8. PMID: 23195348.
      View in: PubMed
    67. Haussen DC, Henninger N, Selim M. Diffusion-weighted imaging of intramural hematoma in internal carotid artery dissection. Acta Neurol Belg. 2013 Mar; 113(1):109-10. PMID: 22975838.
      View in: PubMed
    68. Eder KE, Haussen DC, Searls DE, Henninger N. Reverberating TCD flow pattern in brain death. Neurology. 2012 Aug 28; 79(9):e79. PMID: 22927685.
      View in: PubMed
    69. Haussen DC, Henninger N, Kumar S, Selim M. Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage. Stroke. 2012 Oct; 43(10):2677-81. PMID: 22829545.
      View in: PubMed
    70. Henninger N, Haussen DC, Kumar S. Teaching neuroimages: ictal hyperperfusion. Neurology. 2012 Jun 5; 78(23):e146. PMID: 22665148.
      View in: PubMed
    71. Henninger N, Lin E, Baker SP, Wakhloo AK, Takhtani D, Moonis M. Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion. Cerebrovasc Dis. 2012; 33(6):525-31. PMID: 22538962.
      View in: PubMed
    72. Henninger N, Haussen DC, Caplan LR. Pathology of Cerebral Subcortical Infarction. Int. Rev. Thrombosis. 2012; 7:34-43.
    73. Mehra M, Henninger N, Hirsch JA, Chueh J, Wakhloo AK, Gounis MJ. Preclinical acute ischemic stroke modeling. J Neurointerv Surg. 2012 Jul; 4(4):307-13. PMID: 21990535.
      View in: PubMed
    74. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5. PMID: 21372305.
      View in: PubMed
    75. Rivera-Lara L, Henninger N. Delayed sudden coma due to artery of percheron infarction. Arch Neurol. 2011 Mar; 68(3):386-7. PMID: 21403026.
      View in: PubMed
    76. Henninger N, Kumar R, Fisher M. Acute ischemic stroke therapy. Expert Rev Cardiovasc Ther. 2010 Oct; 8(10):1389-98. PMID: 20936925.
      View in: PubMed
    77. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M. MRI of stroke using hyperpolarized 129Xe. NMR Biomed. 2011 Feb; 24(2):170-5. PMID: 20821723.
      View in: PubMed
    78. Kollmar R, Henninger N, Urbanek C, Schwab S. G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke. Exp Transl Stroke Med. 2010; 2:9. PMID: 20388227.
      View in: PubMed
    79. Henninger N, Ahmad N, Morris JG. Intravenous thrombolysis in a patient with known cavernous malformation: a first case report. Am J Emerg Med. 2010 Jan; 28(1):117.e1-3. PMID: 20006229.
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    80. Bråtane BT, Bouley J, Schneider A, Bastan B, Henninger N, Fisher M. Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat. Stroke. 2009 Sep; 40(9):3102-6. PMID: 19644069.
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    81. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14. PMID: 19546536.
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    82. Henninger N, Lin E, Fischer A, Kheradmand A. Leptomeningeal carcinomatosis: a rare complication in esophageal cancer. Acta Neurol Belg. 2009 Jun; 109(2):162. PMID: 19681453.
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    83. Bråtane BT, Bastan B, Fisher M, Bouley J, Henninger N. Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps. Brain Res. 2009 Jul 7; 1279:182-8. PMID: 19427841.
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    84. Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype. Kidney Blood Press Res. 2008; 31(6):421-32. PMID: 19142019.
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    85. Henninger N, Bouley J, Bråtane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol. 2009 Feb; 215(2):290-7. PMID: 19038254.
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    86. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab. 2009 Jan; 29(1):119-29. PMID: 18766195.
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    87. Henninger N, Sicard KM, Li Z, Kulkarni P, Dützmann S, Urbanek C, Schwab S, Fisher M. Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat. Crit Care Med. 2007 Nov; 35(11):2607-14. PMID: 17828037.
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    88. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007 Oct; 38(10):2779-86. PMID: 17761922.
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    89. Henninger N, Heimann A, Kempski O. Electrophysiology and neuronal integrity following systemic arterial hypotension in a rat model of unilateral carotid artery occlusion. Brain Res. 2007 Aug 13; 1163:119-29. PMID: 17632088.
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    90. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1756-63. PMID: 17377514.
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    91. Henninger N, Feldmann RE, Fütterer CD, Schrempp C, Maurer MH, Waschke KF, Kuschinsky W, Schwab S. Spatial learning induces predominant downregulation of cytosolic proteins in the rat hippocampus. Genes Brain Behav. 2007 Mar; 6(2):128-40. PMID: 16643511.
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    92. Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke. 2007 Apr; 38(4):1336-44. PMID: 17322082.
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    93. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1632-42. PMID: 17311078.
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    94. Henninger N, Wang Q, Okun JG, Schwab S, Krause M. Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism Relat Disord. 2007 Dec; 13(8):524-7. PMID: 17240187.
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    95. Fisher M, Henninger N. Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials. Curr Neurol Neurosci Rep. 2007 Jan; 7(1):35-41. PMID: 17217852.
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    96. Bouley J, Fisher M, Henninger N. Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging. Neurosci Lett. 2007 Feb 2; 412(3):185-90. PMID: 17123725.
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    97. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006 Oct; 37(10):2593-600. PMID: 16946164.
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    98. Henninger N, Küppers-Tiedt L, Sicard KM, Günther A, Schneider D, Schwab S. Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats. Exp Neurol. 2006 Oct; 201(2):316-23. PMID: 16814772.
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    99. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke. 2006 May; 37(5):1283-7. PMID: 16556883.
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    100. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006 Nov; 26(11):1451-62. PMID: 16538230.
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    101. Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S, Schäbitz WR. A new model of thromboembolic stroke in the posterior circulation of the rat. J Neurosci Methods. 2006 Sep 30; 156(1-2):1-9. PMID: 16530271.
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    102. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett. 2006 May 8; 398(3):300-5. PMID: 16490315.
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    103. Henninger N, Fisher M. Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment. Cerebrovasc Dis. 2006; 21(1-2):134-6. PMID: 16374000.
      View in: PubMed
    104. Henninger N, Dützmann S, Sicard KM, Kollmar R, Bardutzky J, Schwab S. Impaired spatial learning in a novel rat model of mild cerebral concussion injury. Exp Neurol. 2005 Oct; 195(2):447-57. PMID: 16084512.
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    105. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke. 2005 Sep; 36(9):2000-5. PMID: 16040589.
      View in: PubMed
    106. Kollmar R, Henninger N, Bardutzky J, Schellinger PD, Schäbitz WR, Schwab S. Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study. Exp Neurol. 2004 Nov; 190(1):204-12. PMID: 15473993.
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    107. Schäbitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI. Stroke. 2004 May; 35(5):1175-9. PMID: 15060313.
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