 Brian Anthony Kelch PhD
| Title | Associate Professor |
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| Institution | University of Massachusetts Medical School |
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| Department | Biochemistry and Molecular Pharmacology |
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| Address | University of Massachusetts Medical School
364 Plantation Street, LRB 923
Worcester MA 01605
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| Phone | 508-856-8322 |
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| vCard | Download vCard |
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| Institution | UMMS - School of Medicine |
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| Department | Biochemistry and Molecular Pharmacology |
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| Institution | UMMS - Graduate School of Biomedical Sciences |
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| Department | Biochemistry and Molecular Pharmacology |
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| Institution | UMMS - Graduate School of Biomedical Sciences |
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| Department | Bioinformatics and Computational Biology |
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| Institution | UMMS - Graduate School of Biomedical Sciences |
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| Department | Interdisciplinary Graduate Program |
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| Institution | UMMS - Graduate School of Biomedical Sciences |
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| Department | MD/PhD Program |
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 Biography | Pennsylvania State University, College Park, PA, United States | BS | | Biochemistry & Molecular Bio | | University of California, San Francisco, San Francisco, CA, United States | PHD | | Biochemistry & Molecular Biol |
Overview Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA. Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. Sci Rep. 2018 May 14; 8(1):7511. PMID: 29760455.
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Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure. 2018 Apr 26. PMID: 29779790.
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Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA. Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nat Commun. 2017 Apr 28; 8:15024. PMID: 28452355.
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Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA. The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain. Nucleic Acids Res. 2017 Jan 12. PMID: 28082398.
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Kelch BA. Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. Biopolymers. 2016 Aug; 105(8):532-46. PMID: 26918303.
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Duffy CM, Hilbert BJ, Kelch BA. A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J Mol Biol. 2016 Mar 27; 428(6):1023-40. PMID: 26688547.
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Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA. Structure and mechanism of the ATPase that powers viral genome packaging. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3792-9. PMID: 26150523.
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Bohn MF, Shandilya SM, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA. The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure. 2015 May 5; 23(5):903-11. PMID: 25914058.
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Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH. A structural role for the PHP domain in E. coli DNA polymerase III. BMC Struct Biol. 2013 May 14; 13:8. PMID: 23672456.
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Kelch BA, Salimi NL, Agard DA. Functional modulation of a protein folding landscape via side-chain distortion. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9414-9. PMID: 22635267.
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Kelch BA, Makino DL, O'Donnell M, Kuriyan J. Clamp loader ATPases and the evolution of DNA replication machinery. BMC Biol. 2012 Apr 20; 10:34. PMID: 22520345.
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Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp. Science. 2011 Dec 23; 334(6063):1675-80. PMID: 22194570.
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Simonetta KR, Kazmirski SL, Goedken ER, Cantor AJ, Kelch BA, McNally R, Seyedin SN, Makino DL, O'Donnell M, Kuriyan J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell. 2009 May 15; 137(4):659-71. PMID: 19450514.
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Kelch BA, Agard DA. Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. J Mol Biol. 2007 Jul 20; 370(4):784-95. PMID: 17543987.
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Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA. Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. J Mol Biol. 2007 May 4; 368(3):870-83. PMID: 17382344.
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Saleh L, Kelch BA, Pathickal BA, Baldwin J, Ley BA, Bollinger JM. Mediation by indole analogues of electron transfer during oxygen activation in variants of Escherichia coli ribonucleotide reductase R2 lacking the electron-shuttling tryptophan 48. Biochemistry. 2004 May 25; 43(20):5943-52. PMID: 15147178.
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Fuhrmann CN, Kelch BA, Ota N, Agard DA. The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. J Mol Biol. 2004 May 14; 338(5):999-1013. PMID: 15111063.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2004 | 2 | | 2007 | 2 | | 2009 | 1 | | 2011 | 1 | | 2012 | 2 | | 2013 | 1 | | 2015 | 3 | | 2016 | 1 | | 2017 | 2 | | 2018 | 2 |
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