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Brian Anthony Kelch PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street LRB 923
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    Pennsylvania State University, College Park, PA, United StatesBSBiochemistry & Molecular Bio
    University of California, San Francisco, San Francisco, CA, United StatesPHDBiochemistry & Molecular Biol

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Landeck JT, Pajak J, Norman EK, Sedivy EL, Kelch BA. Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication. J Biol Chem. 2024 Mar 13; 107166. PMID: 38490435.
    2. Landeck JT, Pajak J, Norman EK, Sedivy EL, Kelch BA. Differences in clamp loader mechanism between bacteria and eukaryotes. bioRxiv. 2023 Nov 30. PMID: 38076975.
    3. Magrino J, Munford V, Martins DJ, Homma TK, Page B, Gaubitz C, Freire BL, Lerario AM, Vilar JB, Amorin A, Le?o EKE, Kok F, Menck CF, Jorge AA, Kelch BA. A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder. J Biol Chem. 2023 05; 299(5):104656. PMID: 36990216.
      Citations: 2     Fields:    Translation:HumansCells
    4. Agnello E, Pajak J, Liu X, Kelch BA. Conformational dynamics control assembly of an extremely long bacteriophage tail tube. J Biol Chem. 2023 03; 299(3):103021. PMID: 36791911.
      Citations: 1     Fields:    Translation:Cells
    5. Li H, O'Donnell M, Kelch B. Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage. Bioessays. 2022 11; 44(11):e2200154. PMID: 36116108.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. ?zden C, Sloutsky R, Mitsugi T, Santos N, Agnello E, Gaubitz C, Foster J, Lapinskas E, Esposito EA, Saneyoshi T, Kelch BA, Garman SC, Hayashi Y, Stratton MM. CaMKII binds both substrates and activators at the active site. Cell Rep. 2022 07 12; 40(2):111064. PMID: 35830796.
      Citations: 5     Fields:    Translation:Cells
    7. Liu X, Gaubitz C, Pajak J, Kelch BA. A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife. 2022 06 22; 11. PMID: 35731107.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch BA. Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife. 2022 02 18; 11. PMID: 35179493.
      Citations: 13     Fields:    Translation:AnimalsCells
    9. Pajak J, Dill E, Reyes-Aldrete E, White MA, Kelch BA, Jardine PJ, Arya G, Morais MC. Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Res. 2021 06 21; 49(11):6474-6488. PMID: 34050764.
      Citations: 9     Fields:    Translation:Cells
    10. Pajak J, Atz R, Hilbert BJ, Morais MC, Kelch BA, Jardine PJ, Arya G. Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33888587.
      Citations: 6     Fields:    Translation:Cells
    11. Calvo JA, Fritchman B, Hernandez D, Persky NS, Johannessen CM, Piccioni F, Kelch BA, Cantor SB. Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. Mol Cancer Res. 2021 06; 19(6):1015-1025. PMID: 33619228.
      Citations: 6     Fields:    Translation:HumansCells
    12. Nixon CF, Lim SA, Sailer ZR, Zheludev IN, Gee CL, Kelch BA, Harms MJ, Marqusee S. Exploring the Evolutionary History of Kinetic Stability in the a-Lytic Protease Family. Biochemistry. 2021 01 26; 60(3):170-181. PMID: 33433210.
      Citations:    Fields:    Translation:Cells
    13. Gaubitz C, Liu X, Magrino J, Stone NP, Landeck J, Hedglin M, Kelch BA. Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23571-23580. PMID: 32907938.
      Citations: 16     Fields:    Translation:HumansCells
    14. Hayes JA, Hilbert BJ, Gaubitz C, Stone NP, Kelch BA. A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry. J Biol Chem. 2020 03 20; 295(12):3783-3793. PMID: 32014998.
      Citations: 4     Fields:    Translation:Cells
    15. Stone NP, Demo G, Agnello E, Kelch BA. Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure. Nat Commun. 2019 10 02; 10(1):4471. PMID: 31578335.
      Citations: 22     Fields:    Translation:Cells
    16. Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T. Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Res. 2019 07 26; 47(13):6826-6841. PMID: 31114918.
      Citations: 12     Fields:    Translation:AnimalsCells
    17. Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure. 2018 07 03; 26(7):936-947.e3. PMID: 29779790.
      Citations: 12     Fields:    Translation:Cells
    18. Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA. Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. Sci Rep. 2018 05 14; 8(1):7511. PMID: 29760455.
      Citations: 28     Fields:    Translation:HumansCells
    19. Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA. Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nat Commun. 2017 04 28; 8:15024. PMID: 28452355.
      Citations: 81     Fields:    Translation:HumansCells
    20. Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA. The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain. Nucleic Acids Res. 2017 04 07; 45(6):3591-3605. PMID: 28082398.
      Citations: 22     Fields:    Translation:Cells
    21. Kelch BA. Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. Biopolymers. 2016 Aug; 105(8):532-46. PMID: 26918303.
      Citations: 34     Fields:    Translation:HumansAnimals
    22. Duffy CM, Hilbert BJ, Kelch BA. A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J Mol Biol. 2016 Mar 27; 428(6):1023-1040. PMID: 26688547.
      Citations: 12     Fields:    Translation:HumansCells
    23. Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA. Structure and mechanism of the ATPase that powers viral genome packaging. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3792-9. PMID: 26150523.
      Citations: 42     Fields:    Translation:Cells
    24. Bohn MF, Shandilya SMD, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA. The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure. 2015 May 05; 23(5):903-911. PMID: 25914058.
      Citations: 59     Fields:    Translation:HumansCells
    25. Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH. A structural role for the PHP domain in E. coli DNA polymerase III. BMC Struct Biol. 2013 May 14; 13:8. PMID: 23672456.
      Citations: 19     Fields:    Translation:Cells
    26. Kelch BA, Salimi NL, Agard DA. Functional modulation of a protein folding landscape via side-chain distortion. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9414-9. PMID: 22635267.
      Citations: 3     Fields:    Translation:Cells
    27. Kelch BA, Makino DL, O'Donnell M, Kuriyan J. Clamp loader ATPases and the evolution of DNA replication machinery. BMC Biol. 2012 Apr 20; 10:34. PMID: 22520345.
      Citations: 43     Fields:    Translation:AnimalsCells
    28. Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp. Science. 2011 Dec 23; 334(6063):1675-80. PMID: 22194570.
      Citations: 94     Fields:    Translation:Cells
    29. Simonetta KR, Kazmirski SL, Goedken ER, Cantor AJ, Kelch BA, McNally R, Seyedin SN, Makino DL, O'Donnell M, Kuriyan J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell. 2009 May 15; 137(4):659-71. PMID: 19450514.
      Citations: 84     Fields:    Translation:Cells
    30. Kelch BA, Agard DA. Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. J Mol Biol. 2007 Jul 20; 370(4):784-95. PMID: 17543987.
      Citations: 12     Fields:    Translation:Cells
    31. Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA. Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. J Mol Biol. 2007 May 04; 368(3):870-83. PMID: 17382344.
      Citations: 12     Fields:    Translation:Cells
    32. Saleh L, Kelch BA, Pathickal BA, Baldwin J, Ley BA, Bollinger JM. Mediation by indole analogues of electron transfer during oxygen activation in variants of Escherichia coli ribonucleotide reductase R2 lacking the electron-shuttling tryptophan 48. Biochemistry. 2004 May 25; 43(20):5943-52. PMID: 15147178.
      Citations: 4     Fields:    Translation:Cells
    33. Fuhrmann CN, Kelch BA, Ota N, Agard DA. The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. J Mol Biol. 2004 May 14; 338(5):999-1013. PMID: 15111063.
      Citations: 22     Fields:    Translation:Cells
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