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Eduardo M Torres PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB-523
Worcester MA 01605
Phone508-856-4353
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    City College of New York, New York, NY, United StatesBSPhysics
    Weill Cornell Graduate School of Medical Sciences, New York, NY, United StatesPHDPhysiology & Biophysics

    Collapse Overview 
    Collapse overview
    Aneuploidy is defined as the state of having a chromosome number that is not an exact multiple of the haploid number. In humans, aneuploidy is the major cause of miscarriages and mental retardation. Although aneuploidy was recognized as a common feature of cancer cells more than a century ago, little is known about its consequences on cellular physiology. Whether aneuploidy is a result or plays a causative role in tumor initiation, progression, or maintenance remains unclear. Our research interests are focused on understanding how aneuploidy affects cellular physiology and metabolism, and how aneuploidy influences cell evolution leading to further gross genomic alterations. Utilizing Saccharomyces cerevisiae as a model organism, we generated a series of aneuploid strains, each carrying an additional copy of 1 of the 16 yeast chromosomes and characterized their effects on cell physiology. These experiments demonstrated that aneuploidy confers a proliferation disadvantage and alters cellular metabolism independent of the identity of the extra chromosome. More recently, we showed that aneuploid yeast cells can quickly evolve and acquire common genomic alterations that lead to improved cellular fitness. Several gene mutations that we found to improve fitness regulate protein turnover and sphingolipid metabolism. These findings profoundly alter our understanding of aneuploidy and might potentially allow for the future development of novel anti-cancer therapies.
    Collapse Rotation Projects
    Rotations are available in this laboratory. Please contact Dr. Torres for details.

    Collapse Post Docs

    A postdoctoral fellow position is available for a highly motivated candidate to join us in the Program in Molecular Medicine at the University of Massachusetts Medical School. Our research interests are focused on understanding how aneuploidy affects cellular physiology and metabolism, and how aneuploidy influences cell evolution leading to further gross genomic alterations.

     

    The Candidates should have a recent Ph.D or M.D/Ph.D degree in Cancer Biology, Genetics, Biochemistry, Cell Biology or related field. The candidates must also have a proven track record of productivity and research experience. They should be highly motivated, have a strong desire to learn and excellent communication skills.

     

    Applicats should send their CV, summary of previous research and the name of three references that may be contacted to Dr. Eduardo Torres, e-mail: Eduardo.torres@umassmed.edu (address: 364 Plantation Street, LRB -523, Worcester, MA  01605-4321



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hwang S, Cavaliere P, Li R, Zhu LJ, Dephoure N, Torres EM. Consequences of aneuploidy in human fibroblasts with trisomy 21. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). PMID: 33526671.
      Citations: 8     Fields:    Translation:HumansCells
    2. Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Rep. 2019 11 19; 29(8):2473-2488.e5. PMID: 31747614.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    3. Hwang S, Gustafsson HT, O'Sullivan C, Bisceglia G, Huang X, Klose C, Schevchenko A, Dickson RC, Cavaliere P, Dephoure N, Torres EM. Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells. Cell Rep. 2017 12 26; 21(13):3807-3818. PMID: 29281829.
      Citations: 22     Fields:    Translation:AnimalsCells
    4. Wang F, Shin J, Shea JM, Yu J, BoŇ°kovi? A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I. Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 09 19; 5. PMID: 27642011.
      Citations: 18     Fields:    Translation:Animals
    5. Torres EM, Springer M, Amon A. No current evidence for widespread dosage compensation in S. cerevisiae. Elife. 2016 Mar 07; 5:e10996. PMID: 26949255.
      Citations: 22     Fields:    Translation:Animals
    6. Torres E. Yeast as Models of Mitotic Fidelity. Recent Results Cancer Res. 2015; 200:143-64. PMID: 26376876.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Dephoure N, Hwang S, O'Sullivan C, Dodgson SE, Gygi SP, Amon A, Torres EM. Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast. Elife. 2014 Jul 29; 3:e03023. PMID: 25073701.
      Citations: 120     Fields:    Translation:AnimalsCells
    8. Sheltzer JM, Torres EM, Dunham MJ, Amon A. Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12644-9. PMID: 22802626.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    9. Torres EM, Williams BR, Tang YC, Amon A. Thoughts on aneuploidy. Cold Spring Harb Symp Quant Biol. 2010; 75:445-51. PMID: 21289044.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, Gygi SP, Dunham MJ, Amon A. Identification of aneuploidy-tolerating mutations. Cell. 2010 Oct 01; 143(1):71-83. PMID: 20850176.
      Citations: 196     Fields:    Translation:HumansAnimals
    11. Torres EM, Williams BR, Amon A. Aneuploidy: cells losing their balance. Genetics. 2008 Jun; 179(2):737-46. PMID: 18558649.
      Citations: 187     Fields:    Translation:HumansAnimals
    12. Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, Amon A. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 2007 Aug 17; 317(5840):916-24. PMID: 17702937.
      Citations: 456     Fields:    Translation:AnimalsCells
    13. Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10; 281(6):3513-20. PMID: 16293614.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    14. Panchal SC, Kaiser DA, Torres E, Pollard TD, Rosen MK. A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Nat Struct Biol. 2003 Aug; 10(8):591-8. PMID: 12872157.
      Citations: 70     Fields:    Translation:HumansCells
    15. Torres E, Rosen MK. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell. 2003 May; 11(5):1215-27. PMID: 12769846.
      Citations: 71     Fields:    Translation:HumansCells
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