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Nikolaos Kakouros MD, PhD, FRCP, FACC, FSC

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North H2-460
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine


    Collapse Biography 
    Collapse education and training
    University of London, London, , United KingdomBSNeuroscience
    Medical School of University of Athens, Athens, , GreecePHDCardiovascular Science
    University of London, London, , United KingdomMBBS
    University of London, London, , United KingdomMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kakouros N, Fitzgibbons TP. Multimodality Imaging in Aortic Stenosis: Measure twice, cut once. Trends Cardiovasc Med. 2024 Mar 27. PMID: 38552886.
      Citations:    
    2. Mehta S, Kakouros N, Mir T, Loree S, Qureshi W. Prevalence and Outcomes of Patients With Acute Ischemic Stroke With Concomitant ST-Elevation Myocardial Infarction (Results From National Inpatient Sample 2016-2019). Stroke. 2024 Mar 26. PMID: 38529635.
      Citations:    
    3. Stinis CT, Abbas AE, Teirstein P, Makkar RR, Chung CJ, Iyer V, G?n?reux P, Kipperman RM, Harrison JK, Hughes GC, Lyons JM, Rahman A, Kakouros N, Walker J, Roberts DK, Huang PH, Kar B, Dhoble A, Logsdon DP, Khanna PK, Aragon J, McCabe JM. Real-World Outcomes for the Fifth-Generation Balloon Expandable Transcatheter Heart Valve in the United?States. JACC Cardiovasc Interv. 2024 Feb 29. PMID: 38456883.
      Citations:    
    4. Aurigemma GP, Gentile BA, Dickey JB, Fitzgibbons TP, Tighe DA, Kakouros N, Kovell LC, Gottbrecht MF, Narvaez-Guerra O, Qureshi W, Gerson DS, Parker MW. Insights Into the Standard Echocardiographic Views From Multimodality Imaging: Ventricles, Pericardium, Valves, and Atria. J Am Soc Echocardiogr. 2023 Dec; 36(12):1266-1289. PMID: 37549797.
      Citations:    Fields:    Translation:Humans
    5. Mir T, Shafi O, Balla S, Munir MB, Qurehi WT, Kakouros N, Bhat Z, Koul P, Rab T. Intensive Care Admissions and Outcome of Cardiac Arrests; A National Cohort Study From the United States. J Intensive Care Med. 2024 Feb; 39(2):118-124. PMID: 37528646.
      Citations:    Fields:    Translation:Humans
    6. Schaefer A, Bhadra OD, Conradi L, Westermann D, Kellner C, De Backer O, Bajoras V, Sondergaard L, Qureshi WT, Kakouros N, Aldrugh S, Amat-Santos I, Kaneko T, Harloff M, Teles R, Nolasco T, Neves JP, Abecasis M, Werner N, Lauterbach M, Sacha J, Krawczyk K, Trani C, Romagnoli E, Mangieri A, Condello F, Regueiro A, Brugaletta S, Biancari F, Niemel? M, Giannini F, Toselli M, Ruggiero R, Buono A, Maffeo D, Bruno F, Conrotto F, D'Ascenzo F, Savontaus M, Pyk?ri J, Ielasi A, Tespili M, Cimmino M, Albanese M, Biondi-Zoccai G, Corcione N, Morello A, Giordano A. Procedural success in transaxillary transcatheter aortic valve implantation according to type of transcatheter heart valve: results from the multicenter TAXI registry. Clin Res Cardiol. 2024 Jan; 113(1):48-57. PMID: 37138103.
      Citations:    Fields:    Translation:Humans
    7. Sattar Y, Prakash P, Almas T, Mir T, Titus A, Ahmad S, Khan MS, Aggarwal A, Ullah W, Alhharbi A, Kakouros N, Alraies MC, Qureshi WT. Cardiovascular Outcomes of Older versus Newer Generation Transcatheter Aortic Valve Replacement Recipients: A Systematic Review & Meta-analysis. Curr Probl Cardiol. 2022 Oct 20; 48(2):101467. PMID: 36272548.
      Citations: 1     Fields:    
    8. Hariri E, Kakouros N, Bunsick DA, Russell SD, Mudd JO, Laws K, Lake MW, Rade JJ. Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure. Am J Physiol Heart Circ Physiol. 2022 07 01; 323(1):H248-H255. PMID: 35714178.
      Citations: 1     Fields:    Translation:Humans
    9. Rade JJ, Barton BA, Vasan RS, Kronsberg SS, Xanthakis V, Keaney JF, Hamburg NM, Kakouros N, Kickler TA. Association of Thromboxane Generation?With Survival in Aspirin?Users?and Nonusers. J Am Coll Cardiol. 2022 07 19; 80(3):233-250. PMID: 35660296.
      Citations: 6     Fields:    Translation:Humans
    10. Giordano A, Schaefer A, Bhadra OD, Conradi L, Westermann D, DE Backer O, Bajoras V, Sondergaard L, Qureshi WT, Kakouros N, Aldrugh S, Amat-Santos I, Santos Mart?nez S, Kaneko T, Harloff M, Teles R, Nolasco T, Neves JP, Abecasis M, Werner N, Lauterbach M, Sacha J, Krawczyk K, Trani C, Romagnoli E, Mangieri A, Condello F, Regueiro A, Brugaletta S, Biancari F, Niemel? M, Giannini F, Toselli M, Ruggiero R, Buono A, Maffeo D, Bruno F, Conrotto F, D'Ascenzo F, Savontaus M, Pyk?ri J, Ielasi A, Tespili M, Corcione N, Ferraro P, Morello A, Albanese M, Biondi-Zoccai G. Percutaneous vs surgical axillary access for transcatheter aortic valve implantation: the TAXI registry. Panminerva Med. 2022 May 30. PMID: 35638242.
      Citations: 2     Fields:    
    11. Eerdekens R, Tonino P, Zelis J, Adrichem R, Ahn JM, Demandt J, Eftekhari A, El Farissi M, Freeman P, Rahman Ihdayhid A, Kakouros N, Kim DH, Lee SA, Van Mieghem NM, Qureshi W, Johnson NP. Rationale and design of SAVI-AoS: A physiologic study of patients with symptomatic moderate aortic valve stenosis and preserved left ventricular ejection fraction. Int J Cardiol Heart Vasc. 2022 Aug; 41:101063. PMID: 35663622.
      Citations:    
    12. Mir T, Qureshi WT, Uddin M, Soubani A, Saydain G, Rab T, Kakouros N. Predictors and outcomes of cardiac arrest in the emergency department and in-patient settings in the United States (2016-2018). Resuscitation. 2022 01; 170:100-106. PMID: 34801637.
      Citations: 2     Fields:    Translation:Humans
    13. Wilkie GL, Qureshi WT, O'Day KW, Aurigemma GP, Goldberg RJ, Amjad W, Alqalyoobi S, Kakouros N, Lauring JR, Leftwich HK, Harrington CM. Cardiac and Obstetric Outcomes Associated With Mitral Valve Prolapse. Am J Cardiol. 2022 01 01; 162:150-155. PMID: 34689956.
      Citations:    Fields:    Translation:Humans
    14. Mir T, Qureshi WT, Uddin M, Shafi O, Sheikh M, Kakouros N. Non-ST elevation myocardial infarction and cardiac arrest: The United States Nationwide Emergency Department Sample. J Cardiol. 2022 01; 79(1):98-104. PMID: 34470713.
      Citations:    Fields:    Translation:Humans
    15. Qureshi WT, Kundu A, Mir T, Khan A, Anwaruddin S, Sattar Y, Ogunsua A, Dutta A, Majeed CN, Walker J, Kakouros N. Meta-analysis of minimalist versus standard care approach for transcatheter aortic valve replacement. Expert Rev Cardiovasc Ther. 2021 Jun; 19(6):565-574. PMID: 33896312.
      Citations:    Fields:    Translation:Humans
    16. Kundu A, Ogunsua AA, Walker J, Qureshi WT, Kakouros N. Bilateral vas deferens calcification in a patient with multi-vessel coronary artery disease and severe aortic stenosis: linking infertility with cardiovascular disease. J Community Hosp Intern Med Perspect. 2021; 11(3):376-378. PMID: 34234910.
      Citations:    
    17. Soueid AE, Kassas I, Rade J, Kakouros N. Evaluation of a Real-World In-Hospital Antiplatelet-Switching Strategy Following Coronary Interventions: The SWITCH Study. J Invasive Cardiol. 2021 04; 33(4):E263-E268. PMID: 33794478.
      Citations:    Fields:    Translation:Humans
    18. Choudhary KV, Kakouros N, Aurigemma GP, Parker MW, Fitzgibbons T. Differentiating Pseudo Versus True Aortic Stenosis in Patients Without Contractile Reserve: A Diagnostic Dilemma. Cureus. 2021 Mar 24; 13(3):e14086. PMID: 33903843.
      Citations:    
    19. Qureshi WT, Parker M, Walker J, Kakouros N. Equipment entrapment during redo-TAVR with successful BASILICA procedure. Catheter Cardiovasc Interv. 2021 08 01; 98(2):E320-E323. PMID: 33484070.
      Citations:    Fields:    Translation:Humans
    20. Qureshi WT, Ogunsua AA, Kundu A, Sattar Y, Fisher DZ, Kakouros N. Angled Microcatheter Assisted Antegrade Dissection Re-Entry Technique for Tortuous Totally Occluded Coronary Arteries. Cardiovasc Revasc Med. 2021 07; 28S:127-131. PMID: 33500228.
      Citations:    Fields:    Translation:Humans
    21. Qureshi WT, Kakouros N, Fahed J, Rade JJ. Comparison of Prevalence, Presentation, and Prognosis of Acute Coronary Syndromes in =35 years, 36 - 54 years, and = 55 years Patients. Am J Cardiol. 2021 02 01; 140:1-6. PMID: 33166493.
      Citations: 4     Fields:    Translation:Humans
    22. Qureshi WT, Malhotra R, Schmidlin EJ, Ahmed M, Kundu A, Hafiz AM, Walker J, Kakouros N. Evaluation of ECG-gated and Fast Low-Angle Shot (FLASH) Dual Source Computed Tomography Scanning Protocols for Transcatheter Aortic Valve Replacement. Acad Radiol. 2021 12; 28(12):1669-1674. PMID: 32972842.
      Citations:    Fields:    Translation:Humans
    23. Qureshi WT, Al-Drugh S, Ogunsua A, Harrington C, Aman W, Balsam L, Kar B, Aurigemma G, Kundu A, Kaur N, Smith C, Fisher D, Rade J, Kakouros N. Post-Myocardial Infarction Complications During the COVID-19 Pandemic - A Case Series. Cardiovasc Revasc Med. 2021 07; 28S:253-258. PMID: 32863191.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    24. Kanei Y, Qureshi W, Walker J, Kakouros N. Guide Extension-Assisted Stent Implantation at Ostial Right Coronary Artery Creating Stent Tunnel During Transcatheter Aortic Valve Replacement. Cardiovasc Revasc Med. 2020 11; 21(11S):50-53. PMID: 32473909.
      Citations:    Fields:    Translation:Humans
    25. Hafiz AM, Perras M, Kakouros N. Acquired Coronary Fenestration. J Invasive Cardiol. 2019 Dec; 31(12):E396. PMID: 31786535.
      Citations:    Fields:    Translation:Humans
    26. Kundu A, Sardar P, Malhotra R, Qureshi WT, Kakouros N. Cardiovascular Outcomes with Transcatheter vs. Surgical Aortic Valve Replacement in Low-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials. Cardiovasc Revasc Med. 2020 04; 21(4):453-460. PMID: 31669113.
      Citations: 1     Fields:    Translation:Humans
    27. Kassas I, Nagy A, Alonso A, Akhter MW, Smith CS, Ahmed M, Hafiz AM, Walker J, Kakouros N. Orbital Atherectomy for Calcific Coronary Artery Disease in Patients With Severe Aortic Stenosis: A Safety and Feasibility Study. J Invasive Cardiol. 2019 Jul; 31(7):E205-E210. PMID: 31257215.
      Citations:    Fields:    Translation:Humans
    28. Kundu A, Sardar P, Kakouros N, Fisher DZ. Rebuttal: Response to letter by Desch et al. regarding "Outcomes of multivessel vs. culprit lesion-only percutaneous coronary intervention in patients with acute myocardial infarction complicated by cardiogenic shock: Evidence from an updated meta-analysis". Catheter Cardiovasc Interv. 2019 11 15; 94(6):896-897. PMID: 31090240.
      Citations:    Fields:    Translation:Humans
    29. Tachjian A, Sanghai SR, Stencel J, Parker MW, Kakouros N, Aurigemma GP. Estimation of Mean Left Atrial Pressure in Patients with Acute Coronary Syndromes: A Doppler Echocardiographic and Cardiac Catheterization Study. J Am Soc Echocardiogr. 2019 03; 32(3):365-374.e1. PMID: 30660349.
      Citations: 2     Fields:    Translation:Humans
    30. Kundu A, Sardar P, Kakouros N, Malhotra R, Kolte D, Feldman DN, Abbott JD, Fisher DZ. Outcomes of multivessel vs culprit lesion-only percutaneous coronary intervention in patients with acute myocardial infarction complicated by cardiogenic shock: Evidence from an updated meta-analysis. Catheter Cardiovasc Interv. 2019 07 01; 94(1):70-81. PMID: 30593731.
      Citations: 2     Fields:    Translation:Humans
    31. Iskandar A, Mowakeaa S, Sardana M, Fitzgibbons TP, Tighe DA, Parker MW, Kakouros N, McManus D, Aurigemma GP. The presbycardia phenotype: Cardiac remodeling and valvular degeneration in nonagenarians. Echocardiography. 2018 12; 35(12):1974-1981. PMID: 30431175.
      Citations: 3     Fields:    Translation:Humans
    32. Hendrix RJ, Bello RA, Flahive JM, Kakouros N, Aurigemma GP, Keaney JF, Hoffman W, Vassileva CM. Mitral Valve Repair Versus Replacement in Elderly With Degenerative Disease: Analysis of the STS Adult Cardiac Surgery?Database. Ann Thorac Surg. 2019 03; 107(3):747-753. PMID: 30612990.
      Citations: 7     Fields:    Translation:Humans
    33. McNeely C, Zajarias A, Fohtung R, Kakouros N, Walker J, Robbs R, Markwell S, Vassileva CM. Racial Comparisons of the Outcomes of Transcatheter and Surgical Aortic Valve Implantation Using the Medicare Database. Am J Cardiol. 2018 08 01; 122(3):440-445. PMID: 30201109.
      Citations: 6     Fields:    Translation:Humans
    34. Taleb A, Parikh G, Kakouros N. Longitudinal Deformation of Distal Edge in a New-Generation Stent Caused by Guidewire Entrapment. Tex Heart Inst J. 2018 02; 45(1):45-47. PMID: 29556153.
      Citations: 1     Fields:    Translation:Humans
    35. Kakouros N, Kakouros SN. Pacemaker malfunction risks within the electromagnetically rich hospital environment. Hellenic J Cardiol. 2018 Jul - Aug; 59(4):247-248. PMID: 29154816.
      Citations:    Fields:    Translation:Humans
    36. Kakouros N, Gluckman TJ, Conte JV, Kickler TS, Laws K, Barton BA, Rade JJ. Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long-Term Outcome After Cardiac Surgery. J Am Heart Assoc. 2017 Nov 02; 6(11). PMID: 29097390.
      Citations: 1     Fields:    Translation:Humans
    37. Hafiz AM, Smith C, Kakouros N. The GuideLiner-Sleeve Technique: A Novel Technique for High-Risk PCI Using Two Left Main Guides for Orbital Atherectomy of Two-Vessel Calcified Ostial Coronary Artery Disease. J Invasive Cardiol. 2017 Nov; 29(11):E159-E160. PMID: 29086733.
      Citations:    Fields:    Translation:Humans
    38. Alexander B, Angaramo G, Walz JM, Kakouros N, Moiz Hafiz A, Walker J, Krapchev P. A Novel Approach to Managing Trans-Subclavian Transcatheter Aortic Valve Replacement With Regional Anesthesia. J Cardiothorac Vasc Anesth. 2018 06; 32(3):1391-1393. PMID: 29128481.
      Citations: 2     Fields:    Translation:Humans
    39. Parikh GR, Peter E, Kakouros N. Complex Coronary Hemodynamics - Simple Analog Modelling as an Educational Tool. Open Med Inform J. 2017; 11:12-19. PMID: 28932342.
      Citations:    
    40. Hafiz AM, Medranda GA, Kakouros N, Patel J, Kahan J, Gubernikoff G, Ray B, Paruchuri V, DeLeon J, Marzo K, Calixte R, Gaztanaga J. Is intra-procedure three-dimensional transesophageal echocardiogram an alternative to preprocedure multidetector computed tomography for the measurement of the aortic annulus in patients undergoing transcatheter aortic valve replacement? Echocardiography. 2017 Aug; 34(8):1195-1202. PMID: 28722306.
      Citations: 3     Fields:    Translation:Humans
    41. Hafiz AM, Shih J, Kakouros N. Transcatheter Tricuspid Valve Replacement in Orthotopic Heart Transplant. J Invasive Cardiol. 2017 Jun; 29(6):E75-E76. PMID: 28570244.
      Citations:    Fields:    Translation:Humans
    42. Alame AJ, Karatasakis A, Karacsonyi J, Danek BA, Sorajja P, G?ssl M, Garcia S, Jneid H, Kakouros N, Martinez-Parachini JR, Resendes E, Kalsaria P, Roesle M, Rangan BV, Banerjee S, Brilakis ES. Comparison of the American College of Cardiology/American Heart Association and the European Society of Cardiology Guidelines for the Management of Patients With Valvular Heart Disease. J Invasive Cardiol. 2017 Sep; 29(9):320-326. PMID: 28420803.
      Citations: 3     Fields:    Translation:Humans
    43. Sardar P, Kundu A, Chatterjee S, Feldman DN, Owan T, Kakouros N, Nairooz R, Pape LA, Feldman T, Dawn Abbott J, Elmariah S. Transcatheter versus surgical aortic valve replacement in intermediate-risk patients: Evidence from a meta-analysis. Catheter Cardiovasc Interv. 2017 Sep 01; 90(3):504-515. PMID: 28398671.
      Citations: 6     Fields:    Translation:Humans
    44. Rana G, Malhotra R, Sharma A, Kakouros N. Percutaneous Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis. Tex Heart Inst J. 2017 Feb; 44(1):43-49. PMID: 28265212.
      Citations: 2     Fields:    Translation:Humans
    45. Mowakeaa S, Snyder B, Kakouros N. Use of orbital atherectomy in acute myocardial infarction via the transradial approach. Interv Med Appl Sci. 2016 Dec; 8(4):178-180. PMID: 28180008.
      Citations:    
    46. Kakouros N. Storage of Fractional Flow Reserve Hemodynamic Waveforms Using Semantic Extension of the DICOM Standard. J Digit Imaging. 2016 06; 29(3):314-20. PMID: 26527469.
      Citations:    Fields:    Translation:Humans
    47. Kakouros N, Nazarian SM, Stadler PB, Kickler TS, Rade JJ. Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery. J Am Heart Assoc. 2016 Mar 15; 5(3):e002615. PMID: 27068626.
      Citations: 5     Fields:    Translation:HumansCells
    48. Mowakeaa S, Iskandar A, Kakouros N. Neoatherosclerosis in Very Late Stenosis of Bare Metal Stent by Optical Coherence Tomography. Case Rep Cardiol. 2016; 2016:1652065. PMID: 27034852.
      Citations:    
    49. Kakouros N, Rade JJ. Role of Fractional-Flow Reserve in Guiding Percutaneous Revascularization in Stable Coronary Artery Disease. Curr Atheroscler Rep. 2015 Sep; 17(9):52. PMID: 26202795.
      Citations: 2     Fields:    Translation:Humans
    50. Kakouros NS, Kakouros SN. Clinical Assessment in Acute Heart Failure. Hellenic J Cardiol. 2015 Jul-Aug; 56(4):285-301. PMID: 26233768.
      Citations: 1     Fields:    Translation:Humans
    51. Rana G, Shih J, Kakouros N. Percutaneous transcatheter balloon valvuloplasty for bioprosthetic tricuspid valve stenosis in a patient with orthotopic heart transplant. J Invasive Cardiol. 2015 Mar; 27(3):E40-1. PMID: 25740974.
      Citations: 1     Fields:    Translation:Humans
    52. Henninger N, Haussen DC, Kakouros N, Selim M, Searls DE, Kumar S, Schlaug G, Caplan LR. QTc-prolongation in posterior circulation stroke. Neurocrit Care. 2013 Oct; 19(2):167-75. PMID: 23860666.
      Citations: 5     Fields:    Translation:Humans
    53. Kakouros N. Oral anticoagulation and implantation of cardiac rhythm management devices: is heparin a bridge too far? Hellenic J Cardiol. 2013 Mar-Apr; 54(2):150-1. PMID: 23557618.
      Citations:    Fields:    Translation:Humans
    54. Kakouros N. Distributed storage healthcare - the basis of a planet-wide public health care network. Open Med Inform J. 2013; 7:1-7. PMID: 23459171.
      Citations:    
    55. Kakouros N, Rybicki FJ, Mitsouras D, Miller JM. Coronary pressure-derived fractional flow reserve in the assessment of coronary artery stenoses. Eur Radiol. 2013 Apr; 23(4):958-67. PMID: 23179519.
      Citations: 11     Fields:    Translation:Humans
    56. Kapur NK, Bian C, Lin E, Deming CB, Sperry JL, Hansen BS, Kakouros N, Rade JJ. Inhibition of transforming growth factor-? restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011 Oct; 54(4):1117-1123.e1. PMID: 21803524.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    57. Kakouros N, Patel SJ, Redwood S, Wasan BS. Triple-vessel percutaneous coronary revascularization in situs inversus dextrocardia. Cardiol Res Pract. 2010; 2010:606327. PMID: 20631900.
      Citations:    
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