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David Grunwald PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentRNA Therapeutics Institute
AddressAlbert Sherman Center
368 Plantation Street
Worcester MA 01605
Phone774-455-3632
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology


    Collapse Biography 
    Collapse education and training
    Humboldt University Berlin, Berlin, , GermanyBSBiophysics
    Ludwig Maximilian University of Munich, Munich, , GermanyPHDBiophysics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tu LC, Huisman M, Chung YC, Smith CS, Grunwald D. Deconstructing transport-distribution reconstruction in the nuclear-pore complex. Nat Struct Mol Biol. 2018 Dec 05. PMID: 30518848.
      View in: PubMed
    2. Ma H, Tu LC, Naseri A, Chung YC, Grunwald D, Zhang S, Pederson T. CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging. Nat Methods. 2018 Nov; 15(11):928-931. PMID: 30377374.
      View in: PubMed
    3. Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ. A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis. Hum Mol Genet. 2018 Jul 01; 27(13):2406. PMID: 29860498.
      View in: PubMed
    4. Jurynec MJ, Sawitzke AD, Beals TC, Redd MJ, Stevens J, Otterud B, Leppert MF, Grunwald DJ. A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis. Hum Mol Genet. 2018 Jul 01; 27(13):2383-2391. PMID: 29659823.
      View in: PubMed
    5. Klatt Shaw D, Gunther D, Jurynec MJ, Chagovetz AA, Ritchie E, Grunwald DJ. Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling. Dev Cell. 2018 05 21; 45(4):512-525.e5. PMID: 29754802.
      View in: PubMed
    6. Morrow ZT, Maxwell AM, Hoshijima K, Talbot JC, Grunwald DJ, Amacher SL. tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis. Dev Dyn. 2017 10; 246(10):759-769. PMID: 28691257.
      View in: PubMed
    7. Ma H, Tu LC, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T. CRISPR-Cas9 nuclear dynamics and target recognition in living cells. J Cell Biol. 2016 Aug 29; 214(5):529-37. PMID: 27551060.
      View in: PubMed
    8. Ma H, Tu LC, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T. Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow. Nat Biotechnol. 2016 May; 34(5):528-30. PMID: 27088723.
      View in: PubMed
    9. Chen J, Rahman SA, Nikolaitchik OA, Grunwald D, Sardo L, Burdick RC, Plisov S, Liang E, Tai S, Pathak VK, Hu WS. HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E201-8. PMID: 26712001.
      View in: PubMed
    10. Smith C, Lari A, Derrer CP, Ouwehand A, Rossouw A, Huisman M, Dange T, Hopman M, Joseph A, Zenklusen D, Weis K, Grunwald D, Montpetit B. In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p. J Cell Biol. 2015 Dec 21; 211(6):1121-30. PMID: 26694837.
      View in: PubMed
    11. Smith C, Tu LC, Grunwald D. A 4D view on mRNA. Oncotarget. 2015 Oct 6; 6(30):28515-6. PMID: 26387129.
      View in: PubMed
    12. Smith CS, Stallinga S, Lidke KA, Rieger B, Grunwald D. Probability-based particle detection that enables threshold-free and robust in vivo single-molecule tracking. Mol Biol Cell. 2015 Nov 5; 26(22):4057-62. PMID: 26424801.
      View in: PubMed
    13. Smith CS, Preibisch S, Joseph A, Abrahamsson S, Rieger B, Myers E, Singer RH, Grunwald D. Nuclear accessibility of ß-actin mRNA is measured by 3D single-molecule real-time tracking. J Cell Biol. 2015 May 25; 209(4):609-19. PMID: 26008747.
      View in: PubMed
    14. Chen J, Grunwald D, Sardo L, Galli A, Plisov S, Nikolaitchik OA, Chen D, Lockett S, Larson DR, Pathak VK, Hu WS. Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):E5205-13. PMID: 25404326.
      View in: PubMed
    15. Jianbo Chen - Viral Recombination Section David Grunwald - RNA Therapeutics Institute and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605; Luca Sardo - Viral Recombination Section and Andrea Galli - Viral Recombination Section and Sergey Plisov - Viral Recombination Section and Olga A. Nikolaitchik - Viral Recombination Section De Chen - Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702; Stephen Lockett - Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702; Daniel R. Larson - Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892 Vinay K. Pathak - Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702; Wei-Shau Hu - Viral Recombination Section. National Academy of Sciences. Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein. 2014; vol. 111 n(PNAS):E5205-E5213.
    16. Beumer KJ, Trautman JK, Christian M, Dahlem TJ, Lake CM, Hawley RS, Grunwald DJ, Voytas DF, Carroll D. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. G3 (Bethesda). 2013 Oct 03; 3(10):1717-25. PMID: 23979928.
      View in: PubMed
    17. Nieuwenhuizen RP, Lidke KA, Bates M, Puig DL, Grünwald D, Stallinga S, Rieger B. Measuring image resolution in optical nanoscopy. Nat Methods. 2013 Jun; 10(6):557-62. PMID: 23624665.
      View in: PubMed
    18. Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell. 2012 Dec 14; 48(5):799-810. PMID: 23102701.
      View in: PubMed
    19. Grünwald D, Singer RH. Multiscale dynamics in nucleocytoplasmic transport. Curr Opin Cell Biol. 2012 Feb; 24(1):100-6. PMID: 22196930.
      View in: PubMed
    20. Grünwald D, Singer RH, Rout M. Nuclear export dynamics of RNA-protein complexes. Nature. 2011 Jul 20; 475(7356):333-41. PMID: 21776079.
      View in: PubMed
    21. Lionnet T, Wu B, Grünwald D, Singer RH, Larson DR. Nuclear physics: quantitative single-cell approaches to nuclear organization and gene expression. Cold Spring Harb Symp Quant Biol. 2010; 75:113-26. PMID: 21502409.
      View in: PubMed
    22. Dange T, Joseph A, Grünwald D. A perspective of the dynamic structure of the nucleus explored at the single-molecule level. Chromosome Res. 2011 Jan; 19(1):117-29. PMID: 20842420.
      View in: PubMed
    23. Hocine S, Singer RH, Grünwald D. RNA processing and export. Cold Spring Harb Perspect Biol. 2010 Dec; 2(12):a000752. PMID: 20961978.
      View in: PubMed
    24. Grünwald D, Singer RH. In vivo imaging of labelled endogenous ß-actin mRNA during nucleocytoplasmic transport. Nature. 2010 Sep 30; 467(7315):604-7. PMID: 20844488.
      View in: PubMed
    25. Dange T, Grünwald D, Grünwald A, Peters R, Kubitscheck U. Autonomy and robustness of translocation through the nuclear pore complex: a single-molecule study. J Cell Biol. 2008 Oct 6; 183(1):77-86. PMID: 18824568.
      View in: PubMed
    26. Grünwald D, Singer RH, Czaplinski K. Cell biology of mRNA decay. Methods Enzymol. 2008; 448:553-77. PMID: 19111194.
      View in: PubMed
    27. Grünwald D, Shenoy SM, Burke S, Singer RH. Calibrating excitation light fluxes for quantitative light microscopy in cell biology. Nat Protoc. 2008; 3(11):1809-14. PMID: 18974739.
      View in: PubMed
    28. Grünwald D, Martin RM, Buschmann V, Bazett-Jones DP, Leonhardt H, Kubitscheck U, Cardoso MC. Probing intranuclear environments at the single-molecule level. Biophys J. 2008 Apr 1; 94(7):2847-58. PMID: 18065482.
      View in: PubMed
    29. Siebrasse JP, Grünwald D, Kubitscheck U. Single-molecule tracking in eukaryotic cell nuclei. Anal Bioanal Chem. 2007 Jan; 387(1):41-4. PMID: 17033772.
      View in: PubMed
    30. Grünwald D, Spottke B, Buschmann V, Kubitscheck U. Intranuclear binding kinetics and mobility of single native U1 snRNP particles in living cells. Mol Biol Cell. 2006 Dec; 17(12):5017-27. PMID: 16987963.
      View in: PubMed
    31. Grünwald D, Hoekstra A, Dange T, Buschmann V, Kubitscheck U. Direct observation of single protein molecules in aqueous solution. Chemphyschem. 2006 Apr 10; 7(4):812-5. PMID: 16528778.
      View in: PubMed
    32. Grünwald D, Cardoso MC, Leonhardt H, Buschmann V. Diffusion and binding properties investigated by Fluorescence Correlation Spectroscopy (FCS). Curr Pharm Biotechnol. 2005 Oct; 6(5):381-6. PMID: 16248811.
      View in: PubMed
    33. Kubitscheck U, Grünwald D, Hoekstra A, Rohleder D, Kues T, Siebrasse JP, Peters R. Nuclear transport of single molecules: dwell times at the nuclear pore complex. J Cell Biol. 2005 Jan 17; 168(2):233-43. PMID: 15657394.
      View in: PubMed
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