Laura Cristina Alonso MD
Title | Adjunct Associate Professor |
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Institution | University of Massachusetts Medical School |
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Department | Medicine |
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Address | Weill Cornell Medical College 413 E 69th Street, BB-602 New York NY 10021
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Phone | 646-962-5476 |
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vCard | Download vCard |
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Institution | UMMS - School of Medicine |
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Department | Medicine |
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Division | Diabetes |
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Institution | UMMS - Graduate School of Biomedical Sciences |
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Department | Interdisciplinary Graduate Program |
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Biography Harvard University, Cambridge, MA, United States | BA | | Biochemistry | University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA, United States | MD | | |
1989 - 1993 | B.A. Biochemistry, Harvard College | 1993 - 1998 | M.D., University of Pennsylvania | 1998 - 2000 | Residency, Internal Medicine, University of Chicago Hospitals | 2000 - 2002 | Fellowship, Endocrinology, University of Chicago Hospitals | 2002 - 2005 | Research Fellowship, Stem Cell Biology, Rockefeller University | 2006 - 2008 | Instructor of Medicine, University of Pittsburgh | 2008 - 2012 | Assistant Professor of Medicine, University of Pittsburgh | 2013 - 2016 | Editorial Board, Journal of Clinical Endocrinology and Metabolism | 2015 - 2020 | The George F. and Sybil H. Fuller Term Chair in Diabetes , UMass Medical School |
Overview Academic backgroundLaura Alonso is currently Associate Professor of Medicine and Director of Beta Cell Biological Studies at the University of Massachusetts Medical School, in the Department of Medicine, Division of Diabetes. She received her undergraduate degree from Harvard in Biochemistry, and her medical diploma from the University of Pennsylvania. She performed her clinical training in Internal Medicine at the University of Chicago, followed by a fellowship in Endocrinology and Metabolism, also at the University of Chicago. Her training in the basic sciences began during a summer internship with Dr. Eleanor Blakely at the Lawrence Berkeley Laboratory, continued during her undergraduate and medical education with Dr. John Dowling and Dr. Laurence Turka, respectively, and intensified during a five-year postdoctoral fellowship with Dr. Elaine Fuchs which began at the University of Chicago and was completed at the Rockefeller University. Training in Islet Biology commenced with her move to the University of Pittsburgh, where she trained with Dr. Andrew Stewart. Clinical work in Diabetes and EndocrinologyDr. Alonso sees patients in the Diabetes Clinic in the Ambulatory Care Center at the University of Massachusetts, University Campus, as well as rounding on the inpatient Diabetes and Endocrinology Consult service. Regulation of pancreatic beta cell massDr. Alonso's research lab is focused on finding ways to increase the number of insulin-secreting pancreatic beta cells, so as to prevent or treat diabetes. She uses mouse models to determine how nutrients influence beta cell proliferation, with the goal of identifying therapeutic pathways that can be exploited to expand human beta cell mass. Rotation projects are available in pancreatic islet biology, with a focus on how nutrients regulate growth and regeneration of insulin-producing beta cells and glucagon-producing alpha cells. Send me an email, I'm happy to discuss options. Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Sharma RB, Darko C, Alonso LC. Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells. J Biol Chem. 2020 Aug 11. PMID: 32788214.
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Nwosu BU, Yeasmin S, Ayyoub S, Rupendu S, Villalobos-Ortiz TR, Jasmin G, Parajuli S, Zahedi B, Zitek-Morrison E, Alonso LC, Barton BA. Continuous glucose monitoring reduces pubertal hyperglycemia of type 1 diabetes. J Pediatr Endocrinol Metab. 2020 Jul 07. PMID: 32634109.
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Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal. 2019 Dec 03; 12(610). PMID: 31796630.
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Sharma RB, Snyder JT, Alonso LC. Atf6a impacts cell number by influencing survival, death and proliferation. Mol Metab. 2019 Sep; 27S:S69-S80. PMID: 31500833.
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Alonso LC. T2D Risk Genes: Exome Sequencing Goes Straight to the Source. Cell Metab. 2019 Jul 02; 30(1):10-11. PMID: 31269421.
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García-Cadenas I, Yáñez L, Jarque I, Martino R, Pérez-Simón JA, Valcárcel D, Sanz J, Bermúdez A, Muñoz C, Calderón-Cabrera C, García E, Alonso L, Suárez-Lledó M, González Vicent M, Heras I, Viguria MC, Batlle M, Vázquez L, López J, Solano C. Frequency, characteristics, and outcome of PTLD after allo-SCT: A multicenter study from the Spanish group of blood and marrow transplantation (GETH). Eur J Haematol. 2019 Jun; 102(6):465-471. PMID: 30828868.
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Sharma RB, Darko C, Zheng X, Gablaski B, Alonso LC. DNA Damage Does Not Cause BrdU Labeling of Mouse or Human Beta Cells. Diabetes. 2019 Mar 04. PMID: 30833468.
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Harmon DB, Wu C, Dedousis N, Sipula IJ, Stafanovic-Racic M, Schoiswohl G, O'Donnell CP, Alonso LC, Kershaw EE, Kelley EE, O'Doherty RM. Adipose Tissue Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply. Am J Physiol Endocrinol Metab. 2018 Aug 07. PMID: 30086648.
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Kong Y, Hsieh CH, Alonso LC. ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease. Front Endocrinol (Lausanne). 2018; 9:405. PMID: 30087655.
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Kong Y, Ebrahimpour P, Liu Y, Yang C, Alonso LC. Pancreatic Islet Embedding for Paraffin Sections. J Vis Exp. 2018 06 29; (136). PMID: 30010652.
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Nwosu BU, Zhang B, Ayyoub SS, Choi S, Villalobos-Ortiz TR, Alonso LC, Barton BA. Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis. PLoS One. 2018; 13(5):e0196912. PMID: 29768449.
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Ortí G, Sanz J, García-Cadenas I, Sánchez-Ortega I, Alonso L, Jiménez MJ, Sisinni L, Azqueta C, Salamero O, Badell I, Ferra C, de Heredia CD, Parody R, Sanz MA, Sierra J, Piñana JL, Querol S, Valcárcel D. Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocyte infusions. Exp Hematol. 2018 06; 62:24-32. PMID: 29526774.
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Kong Y, Sharma RB, Ly S, Stamateris RE, Jesdale WM, Alonso LC. CDKN2A/B
T2D GWAS Risk-SNPs Impact Locus Gene Expression and Proliferation in Human Islets. Diabetes. 2018 Feb 06. PMID: 29432124.
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Barzaghi F, Amaya Hernandez LC, Neven B, Ricci S, Kucuk ZY, Bleesing JJ, Nademi Z, Slatter MA, Ulloa ER, Shcherbina A, Roppelt A, Worth A, Silva J, Aiuti A, Murguia-Favela L, Speckmann C, Carneiro-Sampaio M, Fernandes JF, Baris S, Ozen A, Karakoc-Aydiner E, Kiykim A, Schulz A, Steinmann S, Notarangelo LD, Gambineri E, Lionetti P, Shearer WT, Forbes LR, Martinez C, Moshous D, Blanche S, Fisher A, Ruemmele FM, Tissandier C, Ouachee-Chardin M, Rieux-Laucat F, Cavazzana M, Qasim W, Lucarelli B, Albert MH, Kobayashi I, Alonso L, Diaz De Heredia C, Kanegane H, Lawitschka A, Seo JJ, Gonzalez-Vicent M, Diaz MA, Goyal RK, Sauer MG, Yesilipek A, Kim M, Yilmaz-Demirdag Y, Bhatia M, Khlevner J, Richmond Padilla EJ, Martino S, Montin D, Neth O, Molinos-Quintana A, Valverde-Fernandez J, Broides A, Pinsk V, Ballauf A, Haerynck F, Bordon V, Dhooge C, Garcia-Lloret ML, Bredius RG, Kalwak K, Haddad E, Seidel MG, Duckers G, Pai SY, Dvorak CC, Ehl S, Locatelli F, Goldman F, Gennery AR, Cowan MJ, Roncarolo MG, Bacchetta R. Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study. J Allergy Clin Immunol. 2018 03; 141(3):1036-1049.e5. PMID: 29241729.
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Lundberg RL, Marino KR, Jasrotia A, Maranda LS, Barton BA, Alonso LC, Nwosu BU. Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of =9 for the detection of partial clinical remission. J Pediatr Endocrinol Metab. 2017 Aug 28; 30(8):823-830. PMID: 28753540.
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Marino KR, Lundberg RL, Jasrotia A, Maranda LS, Thompson MJ, Barton BA, Alonso LC, Nwosu BU. A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes. PLoS One. 2017; 12(5):e0176860. PMID: 28459844.
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Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem. 2016 Jul 29; 291(31):16221-30. PMID: 27226575.
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Kong Y, Sharma RB, Nwosu BU, Alonso LC. Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia. 2016 Aug; 59(8):1579-93. PMID: 27155872.
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Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther. 2016 Aug; 24(7):1247-57. PMID: 27117222.
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Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A. PKC? Is Essential for Pancreatic ß-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016 May; 65(5):1283-96. PMID: 26868297.
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Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, García-Ocaña A, Alonso LC. Glucose Induces Mouse ß-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor. Diabetes. 2016 Apr; 65(4):981-95. PMID: 26740601.
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Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC. Insulin demand regulates ß cell number via the unfolded protein response. J Clin Invest. 2015 Oct 1; 125(10):3831-46. PMID: 26389675.
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Singamsetty S, Shah FA, Guo L, Watanabe Y, McDonald S, Sharma R, Zhang Y, Alonso LC, O'Donnell CP, McVerry BJ. Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice. Appl Physiol Nutr Metab. 2016 Jan; 41(1):12-9. PMID: 26624964.
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Mordes JP, Alonso LC. Evaluation, Medical Therapy, and Course of Adult Persistent Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass Surgery: A Case Series. Endocr Pract. 2015 Mar; 21(3):237-46. PMID: 25100376.
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Behari J, Li H, Liu S, Stefanovic-Racic M, Alonso L, O'Donnell CP, Shiva S, Singamsetty S, Watanabe Y, Singh VP, Liu Q. ß-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. Am J Pathol. 2014 Dec; 184(12):3284-98. PMID: 25300578.
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Sharma RB, Alonso LC. Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. 2014 Jun; 14(6):492. PMID: 24740729.
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Jurczyk A, Bortell R, Alonso LC. Human ß-cell regeneration: progress, hurdles, and controversy. Curr Opin Endocrinol Diabetes Obes. 2014 Apr; 21(2):102-8. PMID: 24569551.
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Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014 Apr 1; 19(4):667-81. PMID: 24703698.
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Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F. The islet estrogen receptor-a is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes. PLoS One. 2014; 9(2):e87941. PMID: 24498408.
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Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocana A, O'Donnell CP, McVerry BJ. Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice. PLoS One. 2013; 8(6):e67716. PMID: 23826335.
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Stamateris RE, Sharma RB, Hollern DA, Alonso LC. Adaptive ß-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. Am J Physiol Endocrinol Metab. 2013 Jul 1; 305(1):E149-59. PMID: 23673159.
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Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocana A, O'Donnell CP. Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia. Eur J Appl Physiol. 2013 Feb; 113(2):467-78. PMID: 22801715.
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Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic ß-cell proliferation. Diabetes. 2012 Aug; 61(8):2004-15. PMID: 22586588.
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Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A. Loss of HGF/c-Met signaling in pancreatic ß-cells leads to incomplete maternal ß-cell adaptation and gestational diabetes mellitus. Diabetes. 2012 May; 61(5):1143-52. PMID: 22427375.
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Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP. Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice. Obesity (Silver Spring). 2012 Jul; 20(7):1403-12. PMID: 22331130.
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Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocana A, Alonso LC. Free fatty acids block glucose-induced ß-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes. 2012 Mar; 61(3):632-41. PMID: 22338094.
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Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A. Activation of protein kinase C-? in pancreatic ß-cells in vivo improves glucose tolerance and induces ß-cell expansion via mTOR activation. Diabetes. 2011 Oct; 60(10):2546-59. PMID: 21911744.
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Molina B, Alonso L, Gonzalez-Vicent M, Andion M, Hernandez C, Lassaletta A, Cormenzana M, Lopez-Ibor B, Villa M, Molina J, Diaz MA. High-dose busulfan and melphalan as conditioning regimen for autologous peripheral blood progenitor cell transplantation in high-risk neuroblastoma patients. Pediatr Hematol Oncol. 2011 Mar; 28(2):115-23. PMID: 21299340.
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Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011 Feb; 60(2):525-36. PMID: 20980460.
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Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia. 2011 Mar; 54(3):572-82. PMID: 20936253.
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Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ. Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness. Crit Care Med. 2009 Sep; 37(9):2596-603. PMID: 19623043.
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Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP. Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol. 2008 Feb 1; 586(3):899-911. PMID: 18033815.
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Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007 Jul; 56(7):1792-801. PMID: 17400928.
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Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):851-7. PMID: 17272786.
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Alonso L, Fuchs E. The hair cycle. J Cell Sci. 2006 Feb 1; 119(Pt 3):391-3. PMID: 16443746.
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Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol. 2005 Aug 15; 170(4):559-70. PMID: 16103225.
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Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol. 2003 Nov 10; 163(3):609-23. PMID: 14610062.
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Alonso L, Fuchs E. Stem cells of the skin epithelium. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11830-5. PMID: 12913119.
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Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev. 2003 May 15; 17(10):1189-200. PMID: 12756224.
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Alonso LC, Rosenfield RL. Molecular genetic and endocrine mechanisms of hair growth. Horm Res. 2003; 60(1):1-13. PMID: 12792148.
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Alonso LC, Rosenfield RL. Oestrogens and puberty. Best Pract Res Clin Endocrinol Metab. 2002 Mar; 16(1):13-30. PMID: 11987895.
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Pohlenz J, Manders L, Sadow PM, Kansal PC, Refetoff S, Weiss RE. A novel point mutation in cluster 3 of the thyroid hormone receptor beta gene (P247L) causing mild resistance to thyroid hormone. Thyroid. 1999 Dec; 9(12):1195-203. PMID: 10646658.
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Rosengard AM, Alonso LC, Korb LC, Baldwin WM, Sanfilippo F, Turka LA, Ahearn JM. Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP). Mol Immunol. 1999 Jul; 36(10):685-97. PMID: 10509819.
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Judge TA, Desai NM, Yang Z, Rostami S, Alonso L, Zhang H, Chen Y, Markman JF, DeMateo RP, Barker CF, Naji A, Turka LA. Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation. 1998 Aug 27; 66(4):426-34. PMID: 9734483.
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Budenz DL, Bennett J, Alonso L, Maguire A. In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1995 Oct; 36(11):2211-5. PMID: 7558714.
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Blakely EA, Daftari IK, Meecham WJ, Alonso LC, Collier JM, Kroll SM, Gillette EL, Lee AC, Lett JT, Cox AB, Castro JR, Char DH. Helium-ion-induced human cataractogenesis. Adv Space Res. 1994 Oct; 14(10):501-5. PMID: 11539986.
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Year | Publications |
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1994 | 1 | 1995 | 1 | 1998 | 1 | 1999 | 2 | 2002 | 1 | 2003 | 4 | 2005 | 1 | 2006 | 1 | 2007 | 3 | 2009 | 1 | 2010 | 2 | 2011 | 2 | 2012 | 5 | 2013 | 2 | 2014 | 5 | 2015 | 3 | 2016 | 5 | 2017 | 3 | 2018 | 6 | 2019 | 5 | 2020 | 2 |
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