Loading...
Header Logo
Keywords
Last Name
Institution

Leslie J Berg PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-8371
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPathology
    DivisionAcademic Pathology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentCenter for AIDS Research


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBABiology
    University of California, Berkeley, Berkeley, CA, United StatesPHDMolecular Biology
    Collapse awards and honors
    2001Pharmingen Investigator Award for Outstanding Contributions to the field of Immunology, American Association of Immunologists
    2002Chestnut Hill Award for Excellence in Research, The Medical Foundation
    2002Outstanding Educator Award, UMMS
    2003Educational Achievement Star Award, UMMS
    2004Women in Science and Health Achievement Award, UMMS
    2006Distinguished Service Award, American Association of Immunologists
    2006Outstanding Mentoring Award, UMMS
    2010Lamar Souter Award for Excellence in Medical Education, UMMS
    2011President, American Association of Immunologists

    Collapse Overview 
    Collapse overview

    Dr. Leslie Berg

    T lymphocyte development and activation

    The research in my laboratory is aimed at understanding the signal transduction pathways importantforTlymphocyte development and activation. For these studies, we use a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology. Our current work focuses on three projects. First, we have identified a tyrosine kinase, Jak3, involved in cytokine receptor signaling, and have generated Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, we have identified a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab we are currently examining the role of this protein in lymphocyte development and activation.



    Collapse Rotation Projects


    Potential Rotation Projects



    Please contact me at leslie.berg@umassmed.edu for information about current rotation projects.



    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr. Berg for additional details.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Marshall NB, Vong AM, Devarajan P, Brauner MD, Kuang Y, Nayar R, Schutten EA, Castonguay CH, Berg LJ, Nutt SL, Swain SL. NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection. J Immunol. 2017 Feb 01; 198(3):1142-1155. PMID: 28031335.
      View in: PubMed
    2. Urban SL, Berg LJ, Welsh RM. Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity. Virology. 2016 Jun; 493:52-9. PMID: 26999026.
      View in: PubMed
    3. Conley JM, Gallagher MP, Berg LJ. T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells. Front Immunol. 2016; 7:76. PMID: 26973653.
      View in: PubMed
    4. Nayar R, Schutten E, Jangalwe S, Durost PA, Kenney LL, Conley JM, Daniels K, Brehm MA, Welsh RM, Berg LJ. IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection. PLoS One. 2015; 10(12):e0144826. PMID: 26714260.
      View in: PubMed
    5. Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression. J Immunol. 2015 Nov 15; 195(10):4822-31. PMID: 26466958.
      View in: PubMed
    6. Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL. TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Rep. 2015 Sep 29; 12(12):2099-110. PMID: 26365183.
      View in: PubMed
    7. Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421.
      View in: PubMed
    8. Pereira RM, Martinez GJ, Engel I, Cruz-Guilloty F, Barboza BA, Tsagaratou A, Lio CW, Berg LJ, Lee Y, Kronenberg M, Bandukwala HS, Rao A. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nat Commun. 2014 Aug 08; 5:4540. PMID: 25105474.
      View in: PubMed
    9. Prince AL, Kraus Z, Carty SA, Ng C, Yin CC, Jordan MS, Schwartzberg PL, Berg LJ. Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways. J Immunol. 2014 Jul 15; 193(2):688-99. PMID: 24943215.
      View in: PubMed
    10. Kapoor VN, Shin HM, Cho OH, Berg LJ, Kang J, Welsh RM. Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection. J Virol. 2014 Sep 1; 88(17):9490-503. PMID: 24942579.
      View in: PubMed
    11. Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ. Innate PLZF+CD4+ aß T cells develop and expand in the absence of Itk. J Immunol. 2014 Jul 15; 193(2):673-87. PMID: 24928994.
      View in: PubMed
    12. Nayar R, Schutten E, Bautista B, Daniels K, Prince AL, Enos M, Brehm MA, Swain SL, Welsh RM, Berg LJ. Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection. J Immunol. 2014 Jun 15; 192(12):5881-93. PMID: 24835398.
      View in: PubMed
    13. Jain N, Miu B, Jiang JK, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas CJ, Sanderson MJ, Berg LJ, Kang J. CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med. 2013 Dec; 19(12):1632-7. PMID: 24270545.
      View in: PubMed
    14. Shin HM, Kapoor VN, Guan T, Kaech SM, Welsh RM, Berg LJ. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013 Oct 17; 39(4):661-75. PMID: 24120360.
      View in: PubMed
    15. Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Sci Signal. 2013 Aug 27; 6(290):ra76. PMID: 23982207.
      View in: PubMed
    16. Malhotra N, Narayan K, Cho OH, Sylvia KE, Yin C, Melichar H, Rashighi M, Lefebvre V, Harris JE, Berg LJ, Kang J. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18; 38(4):681-93. PMID: 23562159.
      View in: PubMed
    17. Yin CC, Cho OH, Sylvia KE, Narayan K, Prince AL, Evans JW, Kang J, Berg LJ. The Tec kinase ITK regulates thymic expansion, emigration, and maturation of ?d NKT cells. J Immunol. 2013 Mar 15; 190(6):2659-69. PMID: 23378428.
      View in: PubMed
    18. Berg LJ. Signaling pathways that regulate T cell development and differentiation. J Immunol. 2012 Dec 15; 189(12):5487-8. PMID: 23225893.
      View in: PubMed
    19. Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang JK, Klein U, Thomas CJ, Berg LJ. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41):E2794-802. PMID: 23011795.
      View in: PubMed
    20. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J. Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes. Nat Immunol. 2012 Apr 01; 13(5):511-8. PMID: 22473038.
      View in: PubMed
    21. Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22; 34(4):492-504. PMID: 21497118.
      View in: PubMed
    22. Marshall HD, Prince AL, Berg LJ, Welsh RM. IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol. 2010 Aug 1; 185(3):1419-28. PMID: 20592282.
      View in: PubMed
    23. Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a002287. PMID: 20519342.
      View in: PubMed
    24. Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH. Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol. 2010 Apr 15; 184(8):4228-35. PMID: 20237289.
      View in: PubMed
    25. Berg LJ. Strength of T cell receptor signaling strikes again. Immunity. 2009 Oct 16; 31(4):529-31. PMID: 19833081.
      View in: PubMed
    26. Shi M, Lin TH, Appell KC, Berg LJ. Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals. J Immunol. 2009 Oct 1; 183(7):4493-501. PMID: 19734221.
      View in: PubMed
    27. Sacristán C, Schattgen SA, Berg LJ, Bunnell SC, Roy AL, Rosenstein Y. Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells. Eur J Immunol. 2009 Sep; 39(9):2584-95. PMID: 19701889.
      View in: PubMed
    28. Felices M, Yin CC, Kosaka Y, Kang J, Berg LJ. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8308-13. PMID: 19416854.
      View in: PubMed
    29. Prince AL, Yin CC, Enos ME, Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev. 2009 Mar; 228(1):115-31. PMID: 19290924.
      View in: PubMed
    30. Schepis D, D'Amato M, Studahl M, Bergström T, Kärre K, Berg L. Herpes simplex virus infection downmodulates NKG2D ligand expression. Scand J Immunol. 2009 May; 69(5):429-36. PMID: 19508374.
      View in: PubMed
    31. Wu W, Berg LJ. c-Abl, an additional tyrosine kinase required for T cell development and function. Cell Cycle. 2008 Dec 15; 7(24):3791. PMID: 19151583.
      View in: PubMed
    32. Berg LJ. The "bubble boy" paradox: an answer that led to a question. J Immunol. 2008 Nov 1; 181(9):5815-6. PMID: 18941168.
      View in: PubMed
    33. Shi M, Lin TH, Appell KC, Berg LJ. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity. 2008 Jun; 28(6):763-73. PMID: 18549798.
      View in: PubMed
    34. Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008 Mar 1; 180(5):3007-18. PMID: 18292523.
      View in: PubMed
    35. Lucas JA, Felices M, Evans JW, Berg LJ. Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk. J Immunol. 2007 Dec 1; 179(11):7561-7. PMID: 18025201.
      View in: PubMed
    36. Berg LJ. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol. 2007 Jun; 7(6):479-85. PMID: 17479128.
      View in: PubMed
    37. Felices M, Falk M, Kosaka Y, Berg LJ. Tec kinases in T cell and mast cell signaling. Adv Immunol. 2007; 93:145-84. PMID: 17383541.
      View in: PubMed
    38. Kosaka Y, Felices M, Berg LJ. Itk and Th2 responses: action but no reaction. Trends Immunol. 2006 Oct; 27(10):453-60. PMID: 16931156.
      View in: PubMed
    39. Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity. 2006 Jul; 25(1):79-91. PMID: 16860759.
      View in: PubMed
    40. Ponganis PJ, Stockard TK, Levenson DH, Berg L, Baranov EA. Intravascular pressure profiles in elephant seals: hypotheses on the caval sphincter, extradural vein and venous return to the heart. Comp Biochem Physiol A Mol Integr Physiol. 2006 Sep; 145(1):123-30. PMID: 16820312.
      View in: PubMed
    41. Ponganis PJ, Stockard TK, Levenson DH, Berg L, Baranov EA. Cardiac output and muscle blood flow during rest-associated apneas of elephant seals. Comp Biochem Physiol A Mol Integr Physiol. 2006 May; 144(1):105-11. PMID: 16574449.
      View in: PubMed
    42. Mayack SR, Berg LJ. Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals. J Immunol. 2006 Feb 15; 176(4):2059-63. PMID: 16455959.
      View in: PubMed
    43. Atherly LO, Brehm MA, Welsh RM, Berg LJ. Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol. 2006 Feb 1; 176(3):1571-81. PMID: 16424186.
      View in: PubMed
    44. Li CR, Berg LJ. Itk is not essential for CD28 signaling in naive T cells. J Immunol. 2005 Apr 15; 174(8):4475-9. PMID: 15814667.
      View in: PubMed
    45. Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol. 2005; 23:549-600. PMID: 15771581.
      View in: PubMed
    46. Miller AT, Wilcox HM, Lai Z, Berg LJ. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity. 2004 Jul; 21(1):67-80. PMID: 15345221.
      View in: PubMed
    47. Berg LJ, Nussenzweig M. Signals that regulate lymphocyte development and differentiation. Curr Opin Immunol. 2004 Apr; 16(2):163-6. PMID: 15023408.
      View in: PubMed
    48. Wilcox HM, Berg LJ. Itk phosphorylation sites are required for functional activity in primary T cells. J Biol Chem. 2003 Sep 26; 278(39):37112-21. PMID: 12842872.
      View in: PubMed
    49. Lucas JA, Miller AT, Atherly LO, Berg LJ. The role of Tec family kinases in T cell development and function. Immunol Rev. 2003 Feb; 191:119-38. PMID: 12614356.
      View in: PubMed
    50. Vergara-Silva A, Schaefer KL, Berg LJ. Compartmentalized Eph receptor and ephrin expression in the thymus. Gene Expr Patterns. 2002 Dec; 2(3-4):261-5. PMID: 12617812.
      View in: PubMed
    51. Vergara-Silva A, Schaefer KL, Berg LJ. Compartmentalized Eph receptor and ephrin expression in the thymus. Mech Dev. 2002 Dec; 119 Suppl 1:S225-9. PMID: 14516690.
      View in: PubMed
    52. Lucas JA, Atherly LO, Berg LJ. The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol. 2002 Jun 15; 168(12):6142-51. PMID: 12055226.
      View in: PubMed
    53. Miller AT, Berg LJ. New insights into the regulation and functions of Tec family tyrosine kinases in the immune system. Curr Opin Immunol. 2002 Jun; 14(3):331-40. PMID: 11973131.
      View in: PubMed
    54. Miller AT, Berg LJ. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J Immunol. 2002 Mar 1; 168(5):2163-72. PMID: 11859102.
      View in: PubMed
    55. Soldevila G, Castellanos C, Malissen M, Berg LJ. Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization. Cell Immunol. 2001 Dec 15; 214(2):123-38. PMID: 12088411.
      View in: PubMed
    56. Cui Y, Hackenmiller R, Berg L, Jean F, Nakayama T, Thomas G, Christian JL. The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. Genes Dev. 2001 Nov 1; 15(21):2797-802. PMID: 11691831.
      View in: PubMed
    57. Berg LJ, Kang J. Molecular determinants of TCR expression and selection. Curr Opin Immunol. 2001 Apr; 13(2):232-41. PMID: 11228418.
      View in: PubMed
    58. Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J Immunol. 2001 Jan 15; 166(2):727-30. PMID: 11145642.
      View in: PubMed
    59. Yang WC, Ching KA, Tsoukas CD, Berg LJ. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J Immunol. 2001 Jan 1; 166(1):387-95. PMID: 11123316.
      View in: PubMed
    60. Baird AM, Lucas JA, Berg LJ. A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol. 2000 Oct 1; 165(7):3680-8. PMID: 11034372.
      View in: PubMed
    61. Berg L, Rönnelid J, Klareskog L, Bucht A. Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness. Clin Exp Immunol. 2000 Apr; 120(1):174-82. PMID: 10759780.
      View in: PubMed
    62. Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21; 275(3):2219-30. PMID: 10636929.
      View in: PubMed
    63. Berg L, Rönnelid J, Sanjeevi CB, Lampa J, Klareskog L. Interferon-gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8. Arthritis Res. 2000; 2(1):75-84. PMID: 11219392.
      View in: PubMed
    64. Thomis DC, Aramburu J, Berg LJ. The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells. J Immunol. 1999 Nov 15; 163(10):5411-7. PMID: 10553066.
      View in: PubMed
    65. Grossman WJ, Verbsky JW, Yang L, Berg LJ, Fields LE, Chaplin DD, Ratner L. Dysregulated myelopoiesis in mice lacking Jak3. Blood. 1999 Aug 1; 94(3):932-9. PMID: 10419884.
      View in: PubMed
    66. Fernandes DM, Baird AM, Berg LJ, Rock KL. A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis. J Immunol. 1999 Aug 1; 163(3):1306-14. PMID: 10415028.
      View in: PubMed
    67. Baird AM, Gerstein RM, Berg LJ. The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol. 1999 Apr; 11(2):157-66. PMID: 10322150.
      View in: PubMed
    68. Yelon D, Schaefer KL, Berg LJ. Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development. J Immunol. 1999 Feb 1; 162(3):1348-58. PMID: 9973389.
      View in: PubMed
    69. Durum SK, Candèias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. J Exp Med. 1998 Dec 21; 188(12):2233-41. PMID: 9858510.
      View in: PubMed
    70. Baird AM, Thomis DC, Berg LJ. T cell development and activation in Jak3-deficient mice. J Leukoc Biol. 1998 Jun; 63(6):669-77. PMID: 9620658.
      View in: PubMed
    71. Liu KQ, Bunnell SC, Gurniak CB, Berg LJ. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med. 1998 May 18; 187(10):1721-7. PMID: 9584150.
      View in: PubMed
    72. Bunnell SC, Berg LJ. The signal transduction of motion and antigen recognition: factors affecting T cell function and differentiation. Genet Eng (N Y). 1998; 20:63-110. PMID: 9666556.
      View in: PubMed
    73. Thomis DC, Lee W, Berg LJ. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J Immunol. 1997 Nov 15; 159(10):4708-19. PMID: 9366394.
      View in: PubMed
    74. Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem. 1997 Oct 3; 272(40):25401-8. PMID: 9312162.
      View in: PubMed
    75. Thomis DC, Berg LJ. The role of Jak3 in lymphoid development, activation, and signaling. Curr Opin Immunol. 1997 Aug; 9(4):541-7. PMID: 9287175.
      View in: PubMed
    76. Yelon D, Berg LJ. Structurally similar TCRs differ in their efficiency of positive selection. J Immunol. 1997 Jun 1; 158(11):5219-28. PMID: 9164939.
      View in: PubMed
    77. Thomis DC, Berg LJ. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997 Jan 20; 185(2):197-206. PMID: 9016869.
      View in: PubMed
    78. Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997 Jan 2; 385(6611):93-7. PMID: 8985255.
      View in: PubMed
    79. Gurniak CB, Thomis DC, Berg LJ. Genomic structure and promoter region of the murine Janus-family tyrosine kinase, Jak3. DNA Cell Biol. 1997 Jan; 16(1):85-94. PMID: 9022047.
      View in: PubMed
    80. Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11; 271(41):25646-56. PMID: 8810341.
      View in: PubMed
    81. Kammer W, Lischke A, Moriggl R, Groner B, Ziemiecki A, Gurniak CB, Berg LJ, Friedrich K. Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling. J Biol Chem. 1996 Sep 27; 271(39):23634-7. PMID: 8798580.
      View in: PubMed
    82. Fayolle C, Abdel-Motal UM, Berg L, Deriaud E, Jondal M, Leclerc C. Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4+ T-cell help. Immunology. 1996 Sep; 89(1):41-5. PMID: 8911138.
      View in: PubMed
    83. Gurniak CB, Berg LJ. A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 1996 Aug 15; 13(4):777-86. PMID: 8761299.
      View in: PubMed
    84. Lyons DS, Lieberman SA, Hampl J, Boniface JJ, Chien Y, Berg LJ, Davis MM. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 1996 Jul; 5(1):53-61. PMID: 8758894.
      View in: PubMed
    85. Yelon D, Spain LM, Lim K, Berg LJ. Alterations in CD4 dependence accompany T cell development and differentiation. Int Immunol. 1996 Jul; 8(7):1077-90. PMID: 8757953.
      View in: PubMed
    86. Gurniak CB, Berg LJ. Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood. 1996 Apr 15; 87(8):3151-60. PMID: 8605329.
      View in: PubMed
    87. Abdel-Motal UM, Berg L, Rosén A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmén J, Magnusson G, Karlsson KA, Jondal M. Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells. Eur J Immunol. 1996 Mar; 26(3):544-51. PMID: 8605919.
      View in: PubMed
    88. Abdel-Motal UM, Berg L, Bengtsson M, Dahmén J, Kihlberg J, Magnusson G, Nilsson U, Jondal M. Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules. J Immunol Methods. 1995 Dec 15; 188(1):21-31. PMID: 8551035.
      View in: PubMed
    89. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3; 270(5237):794-7. PMID: 7481767.
      View in: PubMed
    90. Liao JC, Berg LJ, Jay DG. Chromophore-assisted laser inactivation of subunits of the T-cell receptor in living cells is spatially restricted. Photochem Photobiol. 1995 Nov; 62(5):923-9. PMID: 8570733.
      View in: PubMed
    91. Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, Rudd CE. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8891-5. PMID: 7568038.
      View in: PubMed
    92. Lieberman SA, Spain LM, Wang L, Berg LJ. Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice. Cell Immunol. 1995 Apr 15; 162(1):56-67. PMID: 7704911.
      View in: PubMed
    93. Spain LM, Yelon D, Berg LJ. Do the CD4 and CD8 lineages represent parallel pathways? Semin Immunol. 1994 Aug; 6(4):213-20. PMID: 8000030.
      View in: PubMed
    94. Spain LM, Jorgensen JL, Davis MM, Berg LJ. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J Immunol. 1994 Feb 15; 152(4):1709-17. PMID: 8120380.
      View in: PubMed
    95. Sakaguchi S, Ermak TH, Toda M, Berg LJ, Ho W, Fazekas de St Groth B, Peterson PA, Sakaguchi N, Davis MM. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. J Immunol. 1994 Feb 1; 152(3):1471-84. PMID: 7905503.
      View in: PubMed
    96. Berg LJ. Insights into the role of the immune system in prion diseases. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):429-32. PMID: 7904753.
      View in: PubMed
    97. Spain LM, Berg LJ. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev Immunol. 1994; 4(1):43-53. PMID: 7620325.
      View in: PubMed
    98. Heyeck SD, Berg LJ. Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):669-73. PMID: 8421704.
      View in: PubMed
    99. Spain LM, Berg LJ. Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide. J Exp Med. 1992 Jul 1; 176(1):213-23. PMID: 1319457.
      View in: PubMed
    100. Berg LJ, Frank GD, Davis MM. The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell. 1990 Mar 23; 60(6):1043-53. PMID: 2317862.
      View in: PubMed
    101. Berg LJ, Davis MM. T-cell development in T cell receptor alphabeta transgenic mice. Semin Immunol. 1989 Nov; 1(2):105-16. PMID: 15630812.
      View in: PubMed
    102. Berg LJ. Generation of the T cell repertoire. Curr Opin Immunol. 1989 Oct; 2(1):87-92. PMID: 2692626.
      View in: PubMed
    103. Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 1989 Sep 22; 58(6):1035-46. PMID: 2476238.
      View in: PubMed
    104. Berg LJ, Fazekas de St Groth B, Pullen AM, Davis MM. Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. Nature. 1989 Aug 17; 340(6234):559-62. PMID: 2528070.
      View in: PubMed
    105. Davis MM, Berg LJ, Lin AY, Fazekas de St Groth B, Devaux B, Sagerstrom CG, Bjorkman PJ, Elliott JF. TCR recognition and selection in vivo. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:119-28. PMID: 2700932.
      View in: PubMed
    106. Berg LJ, Fazekas de St Groth B, Ivars F, Goodnow CC, Gilfillan S, Garchon HJ, Davis MM. Expression of T-cell receptor alpha-chain genes in transgenic mice. Mol Cell Biol. 1988 Dec; 8(12):5459-69. PMID: 3266655.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Berg's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (456) concept(s)
    _
    Co-Authors Expand Description
    See all (12) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _