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Michael A King PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentRadiology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-442-4255
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRadiology
    DivisionNuclear Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology


    Collapse Biography 
    Collapse education and training
    State University of New York, Oswego, Oswego, NY, United StatesBAPhysics
    State University of New York, Albany, Albany, NY, United StatesMSPhysics
    University of Rochester, Rochester, NY, United StatesPHDRadiation Biology & Biophysics

    Collapse Overview 
    Collapse overview

    Nuclear Medicine Physics Imaging Research Interests

    • Correction for causes of image degradation in nuclear medicine such as attenuation, distance-dependent spatial-resolution, and scatter
    • Detection, estimation, and correction of all forms of patient motion during imaging
    • Tomographic image reconstruction for SPECT and PET.
    • Combination of CT with SPECT and PET
    • Design of the next generation of SPECT Imaging Systems
    • Assessment of image quality by task performance studies using human and numerical observers.
    • Quantification of activity and assessment of physiological function.
    • Image segmentation and computer vision applications in nuclear medicine.
    • Reduction in radiation dose to patients and personnel
    • Applications of Deep Learning in Nuclear Medicine

    One example of the research accomplishments of the laboratory is our work on the detection and compensation of patient motion during the up to 16 minute period which the patient is required to remain motionless for nuclear medicine studies. We have taken the approach of combining estimates of patient motion as determined from the nuclear medicine images themselves with information from our visual-tracking system (VTS) which tracks the motion of retro-reflective markers on stretchy bands wrapped about the patient to provide a combined correction of respiratory and bodily motion. Once motion is determined it is corrected by inclusion in iterative reconstruction as illustrated in the following figure. These investigations are funded by NIH grant R01-HL122484.

    Clinical SPECT
    Clinical SPECT images showing benefits of respiratory motion correction (RM) as noted in top row versus second row which is without RM correction.

    Another example of our current interests is the development of a multi-pinhole collimator (MPH) for use on one gamma-camera head of a general purpose SPECT system in combination with a fan-beam collimator on the second camera head for high resolution / sensitivity imaging of the striatal region of the brain in I-123 DaTscan imaging for Parkinson’s Disease. A rendering of the collimator is shown below followed by reconstructed simulated images of the strata for MPH, Fan, and Combined imaging. These investigations are funded by NIH grant R01-EB022092.

    MPH collimator
    Rendering of the MPH collimator showing the aperture plate with 9 pinholes.
    XCAT
    A. Example XCAT transverse slice multi-pinhole (MPH) collimator noise-free reconstructions through substantia nigra (left) and the caudate and putamen (right) for 15, 30, and 60 angles for VOI over striata. B. Same for low-energy ultra-high-resolution (LEUHR) fan-beam only collimator reconstruction. C. Same for combined reconstruction using MPH and LEUHR fan-beam collimators. D. Matching slices through original XCAT DaTscan source distribution for substantia nigra (top), and caudate and putamen (bottom) with 8:1 striatal to rest of brain  concentration ratio, and no activity in the ventricles. Note that separation of caudate and putamen can be seen in combined reconstruction.

    The third example of our current investigations is the development of a multi-detector-module multi-pinhole (MPH) SPECT brain-imaging system ideally suited for quantitative dynamic and high-spatial-resolution static SPECT imaging. Dynamic imaging will be enabled by obtaining sufficient angular sampling without the need for rotation. The system will automatically adapt its imaging characteristics (aperture size and number of pinholes open for imaging) in response to the imaging tasks and individual patients. It will thereby optimize lesion detection and quantification, as well as provide optimal data for pharmacokinetic analysis within structures throughout the brain. The prototype design for this system is illustrated in the following computer aided design (CAD) drawings.  These investigations are funded by NIH grant R01-EB022521.

    Frontal view SolidWorks CADRear view SolidWorks CAD
    Shown left is a frontal view and right is a view from behind of SolidWorks CAD renderings of the proposed prototype configuration of the 23 detectors of the system dedicated to brain SPECT imaging. Shown are detector modules with MPH aperture plates towards the brain and circular scintillation detector crystals opposed to them.

    Current Teaching

    Physics of Radiology for Residents Nuclear Medical Physics for Cardiologists A year long course starting in August each year consisting of one-hour lectures plus quizzes on Wednesday mornings each week.

    Physics Review for Radiology Residents Taking the ABR Exam Nuclear Medical Physics for Cardiologists: Lectures, demonstrations, and practice question review for physics portion of ABR exam from January to June.

    List of Graduate Students and Post-Doctoral Fellows List of Graduate Students

    Honors and Awards

    1. Graduated Magna Cum Laude from the State University of New York at Oswego in 1969
    2. Anne-Dorte Achtert, 4th year medical student from Humboldt University, Berlin. Advisor for 1 year research fellowship under Biomedical Sciences Exchange Program, 1996-1997. Manuscript based on directed research (JNC 5:144-152, 1997) won the Best Scientific Paper Award from the Journal of Nuclear Cardiology for 1998.
    3. Daniel deVries, thesis advisor for Doctor's degree (1996) in Biomedical Engineering from Worcester Polytechnic Institute. Paper based on thesis work (JNM 40:1011-1023, 1999) received The Journal of Nuclear Medicine's First Place Award for Outstanding Basic Science Manuscript for 1999.
    4. Ed Hoffman Memorial Award for Outstanding Scientific Contributions to the Field of Computers and Instrumentation in Nuclear Medicine. From Society of Nuclear Medicine Computer and Instrumentation Council. June 5, 2006.
    5. Teacher of the Year Award for excellence in teaching presented by the residents of the Department of Radiology, UMMS, June 11, 2008.
    6. IEEE Nuclear and Plasma Sciences Society 2015 Edward J Hoffman Medical Imaging Scientist Award for contributions to clinical nuclear medicine imaging, especially compensation for realistic physical effects and motion in image reconstruction, emission and transmission imaging geometries, and task-based evaluation methods. Nov 4, 2015.
    7. Charter Member of the Biomedical Imaging Technology-A Study Section, Center for Scientific Review, NIH, from July 1, 2016 to June 30, 2020.
    8. Fellow Society of Nuclear Medicine and Molecular Imaging. June 14, 2020

    Current Grant Support

    1. NIH, No R01-EB022092, Combined Multi-Pinhole and Fan-Beam Brain SPECT. M. A. King, PI, 5/18/2016-2/29/2021 (no cost extension).
    2. NIH, No. R01 EB022521, AdaptiSPECT-C: A Next-Generation, Adaptive Brain-Imaging SPECT System for Drug Discovery and Clinical Imaging, M. A. King, contact PI, L. Furenlid, MPI, G. Zubal, MPI, 9/1/2016-8/30/2021.
    3. NIH, No. R21 EB027250, Wave-Cam: A novel micro-radar imaging array for non-rigid motion estimation in hybrid medical imaging, C. Lindsay, PI, 9/21/2019 – 6/30/2022, Role: Co-investigator.
    4. NIH, No. R01 EB029315, Improving Pediatric SPECT Imaging: Enhanced Lesion Detection with Dose Reduction through Advanced Reconstruction and Motion Correction, M. A. King, contact PI, F. Fahey, MPI, Y. Yang, MPI, 6/01/2020 – 0/29/2024.
    5. NIH, No. R01 HL154687, Optimization of diagnostic accuracy, radiation dose, and patient throughput for cardiac SPECT via advanced and clinically practical cardiac-respiratory motion correction and deep learning, W. Wernick, contact PI, M. A. King, MPI, 06/01/20-05/31/24.
    6. NIH, No. R15 HL150708, Attenuation correction strategies for myocardial perfusion imaging using dual-gated, M. Jin, PI 8/05/2020 – 07/31/2023, $300,000, Role: Co-investigator.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pells S, Zeraatkar N, Kalluri KS, Moore SC, May M, Furenlid LR, Kupinski MA, Kuo PH, King MA. Correction of multiplexing artefacts in multi-pinhole SPECT through temporal shuttering, de-multiplexing of projections, and alternating reconstruction. Phys Med Biol. 2024 Jun 06; 69(12). PMID: 38776948.
      Citations:    
    2. Chen Y, Pretorius PH, Lindsay C, Yang Y, King MA. Respiratory signal estimation for cardiac perfusion SPECT using deep learning. Med Phys. 2024 Feb; 51(2):1217-1231. PMID: 37523268.
      Citations:    Fields:    
    3. Pretorius PH, Liu J, Kalluri KS, Jiang Y, Leppo JA, Dahlberg ST, Kikut J, Parker MW, Keating FK, Licho R, Auer B, Lindsay C, Konik A, Yang Y, Wernick MN, King MA. Observer studies of image quality of denoising reduced-count cardiac single photon emission computed tomography myocardial perfusion imaging by three-dimensional Gaussian post-reconstruction filtering and deep learning. J Nucl Cardiol. 2023 12; 30(6):2427-2437. PMID: 37221409.
      Citations:    Fields:    Translation:Humans
    4. Auer B, K?nik A, Fromme TJ, De Beenhouwer J, Kalluri KS, Lindsay C, Furenlid LR, Kuo PH, King MA. Mesh modeling of system geometry and anatomy phantoms for realistic GATE simulations and their inclusion in SPECT reconstruction. Phys Med Biol. 2023 03 29; 68(7). PMID: 36808915.
      Citations:    Fields:    Translation:Humans
    5. Sun J, Zhang Q, Du Y, Zhang D, Pretorius PH, King MA, Mok GSP. Dual gating myocardial perfusion SPECT denoising using a conditional generative adversarial network. Med Phys. 2022 Aug; 49(8):5093-5106. PMID: 35526225.
      Citations: 3     Fields:    Translation:Humans
    6. Chen X, Hendrik Pretorius P, Zhou B, Liu H, Johnson K, Liu YH, King MA, Liu C. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT. J Nucl Cardiol. 2022 12; 29(6):3379-3391. PMID: 35474443.
      Citations: 4     Fields:    Translation:Humans
    7. Pretorius PH, King MA. Data-driven respiratory signal estimation from temporally finely sampled projection data in conventional cardiac perfusion SPECT imaging. Med Phys. 2022 Jan; 49(1):282-294. PMID: 34859456.
      Citations:    Fields:    Translation:Humans
    8. Zeraatkar N, Kalluri KS, Auer B, May M, Richards RG, Furenlid LR, Kuo PH, King MA. Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner. Biomed Phys Eng Express. 2021 09 22; 7(6). PMID: 34507309.
      Citations: 1     Fields:    Translation:Humans
    9. Liu J, Yang Y, Wernick MN, Pretorius PH, Slomka PJ, King MA. Improving detection accuracy of perfusion defect in standard dose SPECT-myocardial perfusion imaging by deep-learning denoising. J Nucl Cardiol. 2022 Oct; 29(5):2340-2349. PMID: 34282538.
      Citations: 1     Fields:    Translation:Humans
    10. Zhang D, Pretorius PH, Lin K, Miao W, Li J, King MA, Zhu W. A novel deep-learning-based approach for automatic reorientation of 3D cardiac SPECT images. Eur J Nucl Med Mol Imaging. 2021 10; 48(11):3457-3468. PMID: 33797598.
      Citations: 3     Fields:    Translation:Humans
    11. Zeraatkar N, Auer B, Kalluri KS, May M, Momsen NC, Richards RG, Furenlid LR, Kuo PH, King MA. Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system. Phys Med Biol. 2021 03 02; 66(6):065004. PMID: 33352545.
      Citations: 2     Fields:    Translation:Humans
    12. Auer B, Zeraatkar N, Goding JC, K?nik A, Fromme TJ, Kalluri KS, Furenlid LR, Kuo PH, King MA. Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance. Phys Med Biol. 2021 01 27; 66(3):035007. PMID: 33065564.
      Citations: 7     Fields:    Translation:Humans
    13. Zeraatkar N, Kalluri KS, Auer B, Konik A, Fromme TJ, Furenlid LR, Kuo PH, King MA. Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging. IEEE Trans Med Imaging. 2020 12; 39(12):4209-4224. PMID: 32763850.
      Citations: 8     Fields:    
    14. Liu J, Yang Y, Wernick MN, Pretorius PH, King MA. Deep learning with noise-to-noise training for denoising in SPECT myocardial perfusion imaging. Med Phys. 2021 Jan; 48(1):156-168. PMID: 33145782.
      Citations: 12     Fields:    Translation:Humans
    15. K?nik A, Zeraatkar N, Kalluri KS, Auer B, Fromme TJ, He Y, May M, Furenlid LR, Kuo PH, King MA. Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing. IEEE Trans Radiat Plasma Med Sci. 2021 Nov; 5(6):817-825. PMID: 34746540.
      Citations:    
    16. Ozsahin I, Chen L, K?nik A, King MA, Beekman FJ, Mok GSP. The clinical utilities of multi-pinhole single photon emission computed tomography. Quant Imaging Med Surg. 2020 Oct; 10(10):2006-2029. PMID: 33014732.
      Citations:    
    17. Ramon AJ, Yang Y, Pretorius PH, Johnson KL, King MA, Wernick MN. Improving Diagnostic Accuracy in Low-Dose SPECT Myocardial Perfusion Imaging With Convolutional Denoising Networks. IEEE Trans Med Imaging. 2020 09; 39(9):2893-2903. PMID: 32167887.
      Citations: 23     Fields:    Translation:Humans
    18. K?nik A, Auer B, De Beenhouwer J, Kalluri K, Zeraatkar N, Furenlid LR, King MA. Primary, scatter, and penetration characterizations of parallel-hole and pinhole collimators for I-123 SPECT. Phys Med Biol. 2019 12 13; 64(24):245001. PMID: 31746783.
      Citations: 8     Fields:    Translation:Humans
    19. Pretorius PH, Ramon AJ, King MA, Konik A, Dahlberg ST, Parker MW, Botkin NF, Johnson KL, Yang Y, Wernick MN. Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study. J Nucl Cardiol. 2021 04; 28(2):624-637. PMID: 31077073.
      Citations: 3     Fields:    Translation:Humans
    20. Song C, Yang Y, Wernick MN, Pretorius PH, Slomka PJ, King MA. Cardiac motion correction for improving perfusion defect detection in cardiac SPECT at standard and reduced doses of activity. Phys Med Biol. 2019 02 20; 64(5):055005. PMID: 30650394.
      Citations:    Fields:    Translation:Humans
    21. Juan Ramon A, Yang Y, Pretorius PH, Johnson KL, King MA, Wernick MN. Personalized Models for Injected Activity Levels in SPECT Myocardial Perfusion Imaging. IEEE Trans Med Imaging. 2019 06; 38(6):1466-1476. PMID: 30530358.
      Citations: 4     Fields:    Translation:Humans
    22. Juan Ramon A, Yang Y, Wernick MN, Pretorius PH, Johnson KL, Slomka PJ, King MA. Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT. J Nucl Cardiol. 2020 04; 27(2):562-572. PMID: 30406608.
      Citations: 2     Fields:    Translation:Humans
    23. Zhang D, Pretorius PH, Ghaly M, Zhang Q, King MA, Mok GSP. Evaluation of different respiratory gating schemes for cardiac SPECT. J Nucl Cardiol. 2020 04; 27(2):634-647. PMID: 30088195.
      Citations: 8     Fields:    Translation:Humans
    24. Song C, Yang Y, Ramon AJ, Wernick MN, Pretorius PH, Johnson KL, Slomka PJ, King MA. Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses. J Nucl Cardiol. 2019 Oct; 26(5):1526-1538. PMID: 30062470.
      Citations: 2     Fields:    Translation:Humans
    25. Song C, Yang Y, Qi W, Wernick MN, Pretorius PH, King MA. Motion-compensated image reconstruction vs postreconstruction correction in respiratory-binned SPECT with standard and reduced-dose acquisitions. Med Phys. 2018 Jul; 45(7):2991-3000. PMID: 29679508.
      Citations: 3     Fields:    Translation:Humans
    26. K?nik A, De Beenhouwer J, Mukherjee JM, Kalluri K, Banerjee S, Zeraatkar N, Fromme T, King MA. Simulations of a Multi-Pinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging. IEEE Trans Radiat Plasma Med Sci. 2018 Sep; 2(5):444-451. PMID: 31011693.
      Citations:    
    27. Song C, Yang Y, Pretorius PH, King MA. 4D non-local means post-filtering for cardiac gated SPECT. Phys Med Biol. 2018 01 31; 63(3):035026. PMID: 29283356.
      Citations: 3     Fields:    Translation:Humans
    28. Juan Ramon A, Yang Y, Pretorius PH, Slomka PJ, Johnson KL, King MA, Wernick MN. Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy. J Nucl Cardiol. 2018 12; 25(6):2117-2128. PMID: 28537039.
      Citations: 16     Fields:    Translation:Humans
    29. Pretorius PH, Johnson KL, Dahlberg ST, King MA. Investigation of the physical effects of respiratory motion compensation in a large population of patients undergoing Tc-99m cardiac perfusion SPECT/CT stress imaging. J Nucl Cardiol. 2020 02; 27(1):80-95. PMID: 28432671.
      Citations: 8     Fields:    Translation:Humans
    30. Qi W, Yang Y, Song C, Wernick MN, Pretorius PH, King MA. 4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT. IEEE Trans Med Imaging. 2017 08; 36(8):1626-1635. PMID: 28391190.
      Citations: 4     Fields:    Translation:Humans
    31. Middlebrooks EH, Quisling RG, King MA, Carney PR, Roper S, Colon-Perez LM, Mareci TH. The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences. Surg Radiol Anat. 2017 Oct; 39(10):1149-1159. PMID: 28286911.
      Citations: 6     Fields:    Translation:Humans
    32. Dasari PK, K?nik A, Pretorius PH, Johnson KL, Segars WP, Shazeeb MS, King MA. Correction of hysteretic respiratory motion in SPECT myocardial perfusion imaging: Simulation and patient studies. Med Phys. 2017 Feb; 44(2):437-450. PMID: 28032913.
      Citations: 4     Fields:    Translation:Humans
    33. Pretorius PH, Johnson KL, King MA. Evaluation of Rigid-Body Motion Compensation in Cardiac Perfusion SPECT Employing Polar-Map Quantification. IEEE Trans Nucl Sci. 2016 Jun; 63(3):1419-1425. PMID: 28042170.
      Citations:    
    34. Mukherjee JM, Lindsay C, Mukherjee A, Olivier P, Shao L, King MA, Licho R. Improved frame-based estimation of head motion in PET brain imaging. Med Phys. 2016 May; 43(5):2443. PMID: 27147355.
      Citations: 11     Fields:    Translation:Humans
    35. Smyczynski MS, Gifford HC, Dey J, Lehovich A, McNamara JE, Segars WP, King MA. LROC Investigation of Three Strategies for Reducing the Impact of Respiratory Motion on the Detection of Solitary Pulmonary Nodules in SPECT. IEEE Trans Nucl Sci. 2016 Feb; 63(1):130-139. PMID: 27182080.
      Citations:    
    36. Smyczynski MS, Gifford HC, Lehovich A, McNamara JE, Segars WP, Hoffman EA, Tsui BM, King MA. Modeling the respiratory motion of solitary pulmonary nodules and determining the impact of respiratory motion on their detection in SPECT imaging. IEEE Trans Nucl Sci. 2016 Feb; 63(1):117-129. PMID: 27182079.
      Citations:    
    37. King MA, Mukherjee JM, K?nik A, Zubal IG, Dey J, Licho R. Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator. IEEE Trans Nucl Sci. 2016 Feb; 63(1):90-97. PMID: 27182078.
      Citations:    
    38. Qi W, Yang Y, Wernick MN, Pretorius PH, King MA. Limited-angle effect compensation for respiratory binned cardiac SPECT. Med Phys. 2016 Jan; 43(1):443. PMID: 26745937.
      Citations: 8     Fields:    Translation:Humans
    39. K?nik A, Kupinski M, Pretorius PH, King MA, Barrett HH. Comparison of the scanning linear estimator (SLE) and ROI methods for quantitative SPECT imaging. Phys Med Biol. 2015 Aug 21; 60(16):6479-94. PMID: 26247228.
      Citations: 4     Fields:    
    40. Dey J, Segars WP, Pretorius PH, King MA. Effect of Non-Alignment/Alignment of Attenuation Map Without/With Emission Motion Correction in Cardiac SPECT/CT. IEEE Trans Nucl Sci. 2015 Aug; 62(4):1813-1824. PMID: 26543244.
      Citations:    
    41. Dasari PK, Shazeeb MS, K?nik A, Lindsay C, Mukherjee JM, Johnson KL, King MA. Adaptation of the modified Bouc-Wen model to compensate for hysteresis in respiratory motion for the list-mode binning of cardiac SPECT and PET acquisitions: testing using MRI. Med Phys. 2014 Nov; 41(11):112508. PMID: 25370667.
      Citations: 3     Fields:    Translation:Humans
    42. K?nik A, Connolly CM, Johnson KL, Dasari P, Segars PW, Pretorius PH, Lindsay C, Dey J, King MA. Digital anthropomorphic phantoms of non-rigid human respiratory and voluntary body motion for investigating motion correction in emission imaging. Phys Med Biol. 2014 Jul 21; 59(14):3669-82. PMID: 24925891.
      Citations: 8     Fields:    Translation:Humans
    43. Dasari P, Johnson K, Dey J, Lindsay C, Shazeeb MS, Mukherjee JM, Zheng S, King MA. MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies. IEEE Trans Nucl Sci. 2014 Feb 06; 61(1):192-201. PMID: 24817767.
      Citations:    
    44. O'Connor JM, Pretorius PH, Johnson K, King MA. A method to synchronize signals from multiple patient monitoring devices through a single input channel for inclusion in list-mode acquisitions. Med Phys. 2013 Dec; 40(12):122502. PMID: 24320538.
      Citations: 4     Fields:    Translation:Humans
    45. King MA, Dey J, Johnson K, Dasari P, Mukherjee JM, McNamara JE, Konik A, Lindsay C, Zheng S, Coughlin D. Use of MRI to assess the prediction of heart motion with gross body motion in myocardial perfusion imaging by stereotracking of markers on the body surface. Med Phys. 2013 Nov; 40(11):112504. PMID: 24320463.
      Citations: 2     Fields:    Translation:Humans
    46. K?nik A, Kikut J, Lew R, Johnson K, King MA. Comparison of methods of acquiring attenuation maps for cardiac SPECT in the presence of respiratory motion. J Nucl Cardiol. 2013 Dec; 20(6):1093-107. PMID: 24146161.
      Citations: 10     Fields:    Translation:Humans
    47. Mukherjee JM, Hutton BF, Johnson KL, Pretorius PH, King MA. An evaluation of data-driven motion estimation in comparison to the usage of external-surrogates in cardiac SPECT imaging. Phys Med Biol. 2013 Nov 07; 58(21):7625-46. PMID: 24107647.
      Citations: 2     Fields:    Translation:Humans
    48. Jin M, Niu X, Qi W, Yang Y, Dey J, King MA, Dahlberg S, Wernick MN. 4D reconstruction for low-dose cardiac gated SPECT. Med Phys. 2013 Feb; 40(2):022501. PMID: 23387768.
      Citations: 14     Fields:    Translation:Humans
    49. Niu X, Yang Y, King MA. Comparison study of temporal regularization methods for fully 5D reconstruction of cardiac gated dynamic SPECT. Phys Med Biol. 2012 Sep 07; 57(17):5523-42. PMID: 22872160.
      Citations:    Fields:    
    50. Qi W, Yang Y, Niu X, King MA. A quantitative study of motion estimation methods on 4D cardiac gated SPECT reconstruction. Med Phys. 2012 Aug; 39(8):5182-93. PMID: 22894443.
      Citations: 7     Fields:    Translation:Humans
    51. Niu X, Yang Y, Jin M, Wernick MN, King MA. Effects of motion, attenuation, and scatter corrections on gated cardiac SPECT reconstruction. Med Phys. 2011 Dec; 38(12):6571-84. PMID: 22149839.
      Citations: 11     Fields:    Translation:Humans
    52. Dey J, Segars WP, Pretorius PH, Walvick RP, Bruyant PP, Dahlberg S, King MA. Estimation and correction of cardiac respiratory motion in SPECT in the presence of limited-angle effects due to irregular respiration. Med Phys. 2010 Dec; 37(12):6453-65. PMID: 21302801.
      Citations: 23     Fields:    Translation:Humans
    53. Niu X, Yang Y, King MA, Wernick MN. Detectability of perfusion defect in five-dimensional gated-dynamic cardiac SPECT images. Med Phys. 2010 Sep; 37(9):5102-12. PMID: 20964230.
      Citations: 4     Fields:    
    54. Mukherjee JM, Johnson KL, McNamara JE, King MA. Quantitative Study of Rigid-Body and Respiratory Motion of Patients Undergoing Stress and Rest Cardiac SPECT Imaging. IEEE Trans Nucl Sci. 2010 Jun 01; 57(3):1105-1115. PMID: 20694041.
      Citations:    
    55. Niu X, Yang Y, Jin M, Wernick MN, King MA. Regularized Fully 5D Reconstruction of Cardiac Gated Dynamic SPECT Images. IEEE Trans Nucl Sci. 2010; 57(6):1085-1095. PMID: 24049191.
      Citations:    
    56. Dey J, Pan T, Choi DJ, Robotis D, Smyczynski MS, Pretorius PH, King MA. Estimation of Cardiac Respiratory-Motion by Semi-Automatic Segmentation and Registration of Non-Contrast-Enhanced 4D-CT Cardiac Datasets. IEEE Trans Nucl Sci. 2009 Dec 08; 56(6):3662-3671. PMID: 20419041.
      Citations:    
    57. Dey J, King MA. Theoretical and Numerical Study of MLEM and OSEM Reconstruction Algorithms for Motion Correction in Emission Tomography. IEEE Trans Nucl Sci. 2009 Oct 01; 56(5):2739-2749. PMID: 20419053.
      Citations:    
    58. Segars WP, Lalush DS, Frey EC, Manocha D, King MA, Tsui BM. Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI. IEEE Trans Nucl Sci. 2009 Oct 01; 56(5):2728-2738. PMID: 20711514.
      Citations:    
    59. Jin M, Yang Y, Niu X, Marin T, Brankov JG, Feng B, Pretorius PH, King MA, Wernick MN. A quantitative evaluation study of four-dimensional gated cardiac SPECT reconstruction. Phys Med Biol. 2009 Sep 21; 54(18):5643-59. PMID: 19724094.
      Citations: 13     Fields:    Translation:Humans
    60. McNamara JE, Pretorius PH, Johnson K, Mukherjee JM, Dey J, Gennert MA, King MA. A flexible multicamera visual-tracking system for detecting and correcting motion-induced artifacts in cardiac SPECT slices. Med Phys. 2009 May; 36(5):1913-23. PMID: 19544811.
      Citations: 17     Fields:    Translation:Humans
    61. Lehovich A, Bruyant PP, Gifford HS, Schneider PB, Squires S, Licho R, Gindi G, King MA. Impact on reader performance for lesion-detection/ localization tasks of anatomical priors in SPECT reconstruction. IEEE Trans Med Imaging. 2009 Sep; 28(9):1459-67. PMID: 19336295.
      Citations: 7     Fields:    Translation:Humans
    62. Mukherjee JM, McNamara JE, Johnson KL, Dey J, King MA. Estimation of Rigid-Body and Respiratory Motion of the Heart From Marker-Tracking Data for SPECT Motion Correction. IEEE Trans Nucl Sci. 2009 Feb; 56(1):147-155. PMID: 20539825.
      Citations:    
    63. Pretorius PH, King MA. Diminishing the impact of the partial volume effect in cardiac SPECT perfusion imaging. Med Phys. 2009 Jan; 36(1):105-15. PMID: 19235379.
      Citations: 14     Fields:    Translation:Humans
    64. Pereira NF, Gifford HC, Pretorius PH, Smyczynski M, Licho R, Schneider P, Farncombe T, King MA. An evaluation of iterative reconstruction strategies based on mediastinal lesion detection using hybrid Ga-67 SPECT images. Med Phys. 2008 Nov; 35(11):4808-15. PMID: 19070213.
      Citations: 2     Fields:    Translation:Humans
    65. Liu S, King MA, Brill AB, Stabin MG, Farncombe TH. Convolution-Based Forced Detection Monte Carlo Simulation Incorporating Septal Penetration Modeling. IEEE Trans Nucl Sci. 2008 Jun; 55(3):967-974. PMID: 20814585.
      Citations:    
    66. McNamara JE, Bruyant P, Johnson K, Feng B, Lehovich A, Gu S, Gennert MA, King MA. An Assessment of a Low-Cost Visual Tracking System (VTS) to Detect and Compensate for Patient Motion during SPECT. IEEE Trans Nucl Sci. 2008 Jun; 55(3):992-998. PMID: 19081803.
      Citations:    
    67. Pretorius PH, King MA. Spillover Compensation in the Presence of Respiratory Motion Embedded in SPECT Perfusion Data. IEEE Trans Nucl Sci. 2008; 55(1):537-542. PMID: 19907675.
      Citations:    
    68. Liu S, King MA, Brill AB, Stabin MG, Farncombe TH. Accelerated SPECT Monte Carlo Simulation Using Multiple Projection Sampling and Convolution-Based Forced Detection. IEEE Trans Nucl Sci. 2008 Jan 01; 55(1):560-567. PMID: 20811587.
      Citations:    
    69. Lehovich A, Gifford HC, Schneider PB, King MA. Choosing anatomical-prior strength for MAP SPECT reconstruction to maximize lesion detectability. IEEE Nucl Sci Symp Conf Rec (1997). 2007 Oct 26; 6(1):4222-4225. PMID: 19779594.
      Citations:    
    70. Ren K, King MA, Liu J, Siemann J, Altman M, Meyers C, Hughes JA, Meyer EM. The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice. Neuroscience. 2007 Aug 10; 148(1):230-7. PMID: 17640819.
      Citations: 15     Fields:    Translation:AnimalsCells
    71. Beach RD, Depold H, Boening G, Bruyant PP, Feng B, Gifford HC, Gennert MA, Nadella S, King MA. An Adaptive Approach to Decomposing Patient-Motion Tracking Data Acquired During Cardiac SPECT Imaging. IEEE Trans Nucl Sci. 2007 Feb; 54(1):130-139. PMID: 19081763.
      Citations:    
    72. Ren K, Thinschmidt J, Liu J, Ai L, Papke RL, King MA, Hughes JA, Meyer EM. alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience. 2007 Mar 02; 145(1):314-22. PMID: 17218065.
      Citations: 20     Fields:    Translation:AnimalsCells
    73. Gifford HC, Kinahan PE, Lartizien C, King MA. Evaluation of Multiclass Model Observers in PET LROC Studies. IEEE Trans Nucl Sci. 2007; 54:116-123. PMID: 18392119.
      Citations:    
    74. Smyczynski MS, Gifford HC, Lehovich A, McNamara JE, Segars WP, Tsui BM, King MA. Impact of respiratory motion on the detection of small pulmonary nodules in SPECT imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2007; 5:3241-3245. PMID: 19169431.
      Citations:    
    75. Pereira NF, Gifford HC, Pretorius PH, Farncombe T, Smyczynski M, Licho R, Schneider P, King MA. An Evaluation of Iterative Reconstruction Strategies on Mediastinal Lesion Detection Using Hybrid Ga-67 SPECT Images. IEEE Nucl Sci Symp Conf Rec (1997). 2007; 5:3486-3490. PMID: 19169427.
      Citations:    
    76. Gifford HC, King MA. Impact of Mismatched Detector-Blur Models on Ga SPECT Tumor Detection. IEEE Nucl Sci Symp Conf Rec (1997). 2007; 6:4226-4229. PMID: 19890463.
      Citations:    
    77. Soares EJ, King MA, Byrne CL, Gifford HC, Lehovich A. The Influence of Photon Attenuation on Tumor-to-Background and Signal-to-Noise Ratios for SPECT Imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2007; 5:3609-3615. PMID: 19169429.
      Citations:    
    78. Gu S, McNamara JE, Mitra J, Gifford HC, Johnson K, Gennert MA, King MA. Body Deformation Correction for SPECT Imaging. IEEE Trans Nucl Sci. 2007; 4:2708-2714. PMID: 20336188.
      Citations:    
    79. Feng B, King MA. Estimation of 6-Degree-of-Freedom (6-DOF) Rigid-Body Patient Motion From Projection Data by the Principal-Axes Method in Iterative Reconstruction. IEEE Trans Nucl Sci. 2006 Nov; 5:2695-2698. PMID: 24817766.
      Citations:    
    80. Jin M, Yang Y, King MA. Reconstruction of dynamic gated cardiac SPECT. Med Phys. 2006 Nov; 33(11):4384-94. PMID: 17153417.
      Citations: 7     Fields:    Translation:Humans
    81. Feng B, Bruyant PP, Pretorius PH, Beach RD, Gifford HC, Dey J, Gennert M, King MA. Estimation of the Rigid-Body Motion from Three-Dimensional Images Using a Generalized Center-of-Mass Points Approach. IEEE Trans Nucl Sci. 2006 Oct; 53(5):2712-2718. PMID: 19081775.
      Citations:    
    82. Gravier E, Yang Y, King MA, Jin M. Fully 4D motion-compensated reconstruction of cardiac SPECT images. Phys Med Biol. 2006 Sep 21; 51(18):4603-19. PMID: 16953045.
      Citations: 11     Fields:    
    83. Feng B, Gifford HC, Beach RD, Boening G, Gennert MA, King MA. Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT. IEEE Trans Med Imaging. 2006 Jul; 25(7):838-44. PMID: 16827485.
      Citations: 14     Fields:    
    84. Feng B, Fessler JA, King MA. Incorporation of system resolution compensation (RC) in the ordered-subset transmission (OSTR) algorithm for transmission imaging in SPECT. IEEE Trans Med Imaging. 2006 Jul; 25(7):941-9. PMID: 16827494.
      Citations: 9     Fields:    
    85. Feng B, Pretorius PH, Farncombe TH, Dahlberg ST, Narayanan MV, Wernick MN, Celler AM, Leppo JA, King MA. Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime. J Nucl Cardiol. 2006 May-Jun; 13(3):354-61. PMID: 16750780.
      Citations: 8     Fields:    Translation:Humans
    86. Kupinski MA, Hoppin JW, Krasnow J, Dahlberg S, Leppo JA, King MA, Clarkson E, Barrett HH. Comparing cardiac ejection fraction estimation algorithms without a gold standard. Acad Radiol. 2006 Mar; 13(3):329-37. PMID: 16488845.
      Citations: 9     Fields:    Translation:Humans
    87. Gifford HC, Zheng XM, Licho R, Pretorius PH, Schneider PB, Simkin PH, King MA. Factors Influencing Lesion Detection in SPECT Lung Images. IEEE Nucl Sci Symp Conf Rec (1997). 2006; 5:2662-2666. PMID: 19169428.
      Citations:    
    88. Lehovich A, Gifford HC, King MA. Location-known-exactly human-observer ROC studies of attenuation and other corrections for SPECT lung imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2006; 6:3229-3232. PMID: 19194523.
      Citations:    
    89. Gifford HC, Lehovich A, King MA. A Multiclass Model Observer for Multislice-Multiview Images. IEEE Nucl Sci Symp Conf Rec (1997). 2006; 3:1687-1691. PMID: 19194524.
      Citations:    
    90. Lehovich A, Bruyant PP, Gifford HC, Schneider PB, Squires S, Licho R, Gindi G, King MA. Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors. IEEE Nucl Sci Symp Conf Rec (1997). 2006; 3:1699-1702. PMID: 19412357.
      Citations:    
    91. Lee TK, Atkins MS, King MA, Lau S, McLean DI. Counting moles automatically from back images. IEEE Trans Biomed Eng. 2005 Nov; 52(11):1966-9. PMID: 16285401.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    92. Bruyant PP, Gennert MA, Speckert GC, Beach RD, Morgenstern JD, Kumar N, Nadella S, King MA. A Robust Visual Tracking System for Patient Motion Detection in SPECT: Hardware Solutions. IEEE Trans Nucl Sci. 2005 Oct; 52(5 I):1288-1294. PMID: 19081772.
      Citations:    
    93. Pretorius PH, King MA, Gifford HC, Dahlberg ST, Spencer F, Simon E, Rashkin J, Botkin N, Berndt W, Narayanan MV, Leppo JA. Myocardial perfusion SPECT reconstruction: receiver operating characteristic comparison of CAD detection accuracy of filtered backprojection reconstruction with all of the clinical imaging information available to readers and solely stress slices iteratively reconstructed with combined compensation. J Nucl Cardiol. 2005 May-Jun; 12(3):284-93. PMID: 15944533.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    94. Gifford HC, King MA, Pretorius PH, Wells RG. A comparison of human and model observers in multislice LROC studies. IEEE Trans Med Imaging. 2005 Feb; 24(2):160-9. PMID: 15707242.
      Citations: 41     Fields:    Translation:Humans
    95. Beach RD, Pretorius PH, Boening G, Bruyant PP, Feng B, Fulton RR, Gennert MA, Nadella S, King MA. Feasibility of Stereo-Infrared Tracking to Monitor Patient Motion During Cardiac SPECT Imaging. IEEE Trans Nucl Sci. 2004 Oct; 51(5 II):2693-2698. PMID: 19081781.
      Citations:    
    96. Farncombe TH, Gifford HC, Narayanan MV, Pretorius PH, Frey EC, King MA. Assessment of scatter compensation strategies for (67)Ga SPECT using numerical observers and human LROC studies. J Nucl Med. 2004 May; 45(5):802-12. PMID: 15136630.
      Citations: 21     Fields:    Translation:Humans
    97. Narayanan MV, King MA, Pretorius PH, Dahlberg ST, Spencer F, Simon E, Ewald E, Healy E, MacNaught K, Leppo JA. Human-observer receiver-operating-characteristic evaluation of attenuation, scatter, and resolution compensation strategies for (99m)Tc myocardial perfusion imaging. J Nucl Med. 2003 Nov; 44(11):1725-34. PMID: 14602852.
      Citations: 38     Fields:    Translation:Humans
    98. King MA, Yeadon MR. Coping with perturbations to a layout somersault in tumbling. J Biomech. 2003 Jul; 36(7):921-7. PMID: 12757800.
      Citations: 1     Fields:    Translation:Humans
    99. King M, Farncombe T. An overview of attenuation and scatter correction of planar and SPECT data for dosimetry studies. Cancer Biother Radiopharm. 2003 Apr; 18(2):181-90. PMID: 12804043.
      Citations: 11     Fields:    Translation:Humans
    100. Narayanan MV, King MA, Byrne CL. An iterative transmission algorithm incorporating cross-talk correction for SPECT. Med Phys. 2002 May; 29(5):694-700. PMID: 12033564.
      Citations: 3     Fields:    Translation:Humans
    101. King MA, Pretorius PH, Farncombe T, Beekman FJ. Introduction to the physics of molecular imaging with radioactive tracers in small animals. J Cell Biochem Suppl. 2002; 39:221-30. PMID: 12552621.
      Citations: 6     Fields:    Translation:Animals
    102. Bouwens LR, Gifford H, Van de Walle R, King MA, Lemahieu I, Dierckx RA. Resolution recovery for list-mode reconstruction in SPECT. Phys Med Biol. 2001 Aug; 46(8):2239-53. PMID: 11512622.
      Citations: 2     Fields:    
    103. Pretorius PH, Narayanan MV, Dahlberg ST, Leppo JA, King MA. The influence of attenuation and scatter compensation on the apparent distribution of Tc-99m sestamibi in cardiac slices. J Nucl Cardiol. 2001 May-Jun; 8(3):356-64. PMID: 11391306.
      Citations: 5     Fields:    Translation:Humans
    104. Narayanan MV, Byrne CL, King MA. An interior point iterative maximum-likelihood reconstruction algorithm incorporating upper and lower bounds with application to SPECT transmission imaging. IEEE Trans Med Imaging. 2001 Apr; 20(4):342-53. PMID: 11370901.
      Citations: 5     Fields:    Translation:Humans
    105. Beekman FJ, Kamphuis C, King MA, van Rijk PP, Viergever MA. Improvement of image resolution and quantitative accuracy in clinical Single Photon Emission Computed Tomography. Comput Med Imaging Graph. 2001 Mar-Apr; 25(2):135-46. PMID: 11137790.
      Citations: 4     Fields:    Translation:Humans
    106. Wells RG, King MA, Simkin PH, Judy PF, Brill AB, Gifford HC, Licho R, Pretorius PH, Schneider PB, Seldin DW. Comparing filtered backprojection and ordered-subsets expectation maximization for small-lesion detection and localization in 67Ga SPECT. J Nucl Med. 2000 Aug; 41(8):1391-9. PMID: 10945533.
      Citations: 11     Fields:    Translation:Humans
    107. Gifford HC, King MA, Wells RG, Hawkins WG, Narayanan MV, Pretorius PH. LROC analysis of detector-response compensation in SPECT. IEEE Trans Med Imaging. 2000 May; 19(5):463-73. PMID: 11021689.
      Citations: 18     Fields:    Translation:Humans
    108. Narayanan MV, King MA, Wernick MN, Byrne CL, Soares EJ, Pretorius PH. Improved image quality and computation reduction in 4-D reconstruction of cardiac-gated SPECT images. IEEE Trans Med Imaging. 2000 May; 19(5):423-33. PMID: 11021686.
      Citations: 7     Fields:    Translation:Humans
    109. Gifford HC, King MA, de Vries DJ, Soares EJ. Channelized hotelling and human observer correlation for lesion detection in hepatic SPECT imaging. J Nucl Med. 2000 Mar; 41(3):514-21. PMID: 10716327.
      Citations: 49     Fields:    Translation:Humans
    110. Pretorius PH, King MA, Tsui BM, LaCroix KJ, Xia W. A mathematical model of motion of the heart for use in generating source and attenuation maps for simulating emission imaging. Med Phys. 1999 Nov; 26(11):2323-32. PMID: 10587213.
      Citations: 27     Fields:    Translation:Humans
    111. Wells RG, Simkin PH, Judy PF, King MA, Pretorius H, Gifford HC. Effect of filtering on the detection and localization of small Ga-67 lesions in thoracic single photon emission computed tomography images. Med Phys. 1999 Jul; 26(7):1382-8. PMID: 10435542.
      Citations: 6     Fields:    Translation:Humans
    112. de Vries DJ, King MA, Soares EJ, Tsui BM, Metz CE. Effects of scatter substraction on detection and quantitation in hepatic SPECT. J Nucl Med. 1999 Jun; 40(6):1011-23. PMID: 10452320.
      Citations: 3     Fields:    Translation:Humans
    113. Case JA, Licho R, King MA, Weaver JP. Bone SPECT of the spine: a comparison of attenuation correction techniques. J Nucl Med. 1999 Apr; 40(4):604-13. PMID: 10210219.
      Citations: 3     Fields:    Translation:Humans
    114. Licho R, Glick SJ, Xia W, Pan TS, Penney BC, King MA. Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans. J Nucl Med. 1999 Mar; 40(3):456-63. PMID: 10086711.
      Citations: 7     Fields:    Translation:Humans
    115. Tsui BM, Frey EC, LaCroix KJ, Lalush DS, McCartney WH, King MA, Gullberg GT. Quantitative myocardial perfusion SPECT. J Nucl Cardiol. 1998 Sep-Oct; 5(5):507-22. PMID: 9796898.
      Citations: 13     Fields:    Translation:Humans
    116. Kohli V, King MA, Glick SJ, Pan TS. Comparison of frequency-distance relationship and Gaussian-diffusion-based methods of compensation for distance-dependent spatial resolution in SPECT imaging. Phys Med Biol. 1998 Apr; 43(4):1025-37. PMID: 9572525.
      Citations: 7     Fields:    Translation:HumansCells
    117. Achtert AD, King MA, Dahlberg ST, Pretorius PH, LaCroix KJ, Tsui BM. An investigation of the estimation of ejection fractions and cardiac volumes by a quantitative gated SPECT software package in simulated gated SPECT images. J Nucl Cardiol. 1998 Mar-Apr; 5(2):144-52. PMID: 9588666.
      Citations: 25     Fields:    Translation:Humans
    118. Pretorius PH, King MA, Pan TS, de Vries DJ, Glick SJ, Byrne CL. Reducing the influence of the partial volume effect on SPECT activity quantitation with 3D modelling of spatial resolution in iterative reconstruction. Phys Med Biol. 1998 Feb; 43(2):407-20. PMID: 9509535.
      Citations: 14     Fields:    Translation:Humans
    119. Pan TS, Luo DS, Kohli V, King MA. Influence of OSEM, elliptical orbits and background activity on SPECT 3D resolution recovery. Phys Med Biol. 1997 Dec; 42(12):2517-29. PMID: 9434304.
      Citations: 11     Fields:    Translation:Humans
    120. Pretorius PH, Xia W, King MA, Tsui BM, Pan TS, Villegas BJ. Evaluation of right and left ventricular volume and ejection fraction using a mathematical cardiac torso phantom. J Nucl Med. 1997 Oct; 38(10):1528-35. PMID: 9379187.
      Citations: 13     Fields:    Translation:Humans
    121. Pan TS, King MA, Luo DS, Dahlberg ST, Villegas BJ. Estimation of attenuation maps from scatter and photopeak window single photon-emission computed tomographic images of technetium 99m-labeled sestamibi. J Nucl Cardiol. 1997 Jan-Feb; 4(1 Pt 1):42-51. PMID: 9138839.
      Citations: 9     Fields:    Translation:Humans
    122. King MA, Luo D, Dahlberg ST, Villegas BJ, Penney BC, Morgan HT. Transmission imaging of large attenuators using a slant hole collimator on a three-headed SPECT system. Med Phys. 1996 Feb; 23(2):263-72. PMID: 8668108.
      Citations: 1     Fields:    Translation:Humans
    123. Pan TS, King MA, Devries DJ, Ljungberg M. Correction to "segmentation of the body and lungs from compton scatter and photopeak window data in. IEEE Trans Med Imaging. 1996; 15(3):394. PMID: 18215921.
      Citations: 2     Fields:    
    124. Pan TS, King MA, de Vries DJ, Ljungberg M. Segmentation of the body and lungs from Compton scatter and photopeak window data in SPECT: a Monte-Carlo investigation. IEEE Trans Med Imaging. 1996; 15(1):13-24. PMID: 18215885.
      Citations: 13     Fields:    
    125. King MA, Tsui BM, Pan TS, Glick SJ, Soares EJ. Attenuation compensation for cardiac single-photon emission computed tomographic imaging: Part 2. Attenuation compensation algorithms. J Nucl Cardiol. 1996 Jan-Feb; 3(1):55-64. PMID: 8799228.
      Citations: 31     Fields:    Translation:Humans
    126. King MA, Xia W, deVries DJ, Pan TS, Villegas BJ, Dahlberg S, Tsui BM, Ljungberg MH, Morgan HT. A Monte Carlo investigation of artifacts caused by liver uptake in single-photon emission computed tomography perfusion imaging with technetium 99m-labeled agents. J Nucl Cardiol. 1996 Jan-Feb; 3(1):18-29. PMID: 8799224.
      Citations: 18     Fields:    Translation:Humans
    127. King MA, Tsui BM, Pan TS. Attenuation compensation for cardiac single-photon emission computed tomographic imaging: Part 1. Impact of attenuation and methods of estimating attenuation maps. J Nucl Cardiol. 1995 Nov-Dec; 2(6):513-24. PMID: 9420834.
      Citations: 45     Fields:    Translation:Humans
    128. Glick SJ, King MA, Pan TS, Soares EJ. An analytical approach for compensation of non-uniform attenuation in cardiac SPECT imaging. Phys Med Biol. 1995 Oct; 40(10):1677-93. PMID: 8532748.
      Citations: 1     Fields:    Translation:Humans
    129. Weinstein H, King MA, Reinhardt CP, McSherry BA, Leppo JA. A method of simultaneous dual-radionuclide cardiac imaging with technetium 99m and thallium 201. I: Analysis of interradionuclide crossover and validation in phantoms. J Nucl Cardiol. 1994 Jan-Feb; 1(1):39-51. PMID: 9420669.
      Citations: 5     Fields:    Translation:Humans
    130. Ljungberg M, King MA, Hademenos GJ, Strand SE. Comparison of four scatter correction methods using Monte Carlo simulated source distributions. J Nucl Med. 1994 Jan; 35(1):143-51. PMID: 8271036.
      Citations: 15     Fields:    Translation:Humans
    131. Glick SJ, Penney BC, King MA, Byrne CL. Noniterative compensation for the distance-dependent detector response and photon attenuation in SPECT imaging. IEEE Trans Med Imaging. 1994; 13(2):363-74. PMID: 18218512.
      Citations: 17     Fields:    
    132. Soares EJ, Byrne CL, Glick SJ, Appledorn CR, King MA. Implementation and evaluation of an analytical solution to the photon attenuation and non-stationary resolution reconstruction problem in SPECT. IEEE Trans Nucl Sci. 1993; 40:1231-1237.
    133. Hademenos GJ, Ljungberg M, King MA, Glick SJ. A Monte Carlo investigation of the dual photopeak window scatter correction method. IEEE Trans Nucl Sci. 1993; 40:179-185.
    134. Glick SJ, Hawkins WG, King MA, Penney BC, Soares EJ, Byrne CL. The effect of intrinsic attenuation correction methods on the stationarity of the 3-D modulation transfer function of SPECT. Med Phys. 1992 Jul-Aug; 19(4):1105-12. PMID: 1518474.
      Citations: 6     Fields:    Translation:Humans
    135. King MA, Hademenos GJ, Glick SJ. A dual-photopeak window method for scatter correction. J Nucl Med. 1992 Apr; 33(4):605-12. PMID: 1552349.
      Citations: 31     Fields:    
    136. Long DT, King MA, Sheehan J. Comparative evaluation of image segmentation methods for volume quantitation in SPECT. Med Phys. 1992 Mar-Apr; 19(2):483-9. PMID: 1584149.
      Citations: 8     Fields:    
    137. Clarke LP, Cullom SJ, Shaw R, Reece C, Penney BC, King MA, Silbiger M. Bremsstrahlung imaging using the gamma camera: Factors affecting attenuation. J Nucl Med. 1992; 33:161-166.
    138. Ljungberg M, King MA, Strand SE. Quantitative SPECT: Verification for sources in an elliptical water phantom. Eur J Nucl Med. 1992; 19:838-844.
    139. Ljungberg MH, King MA, Strand SE. Quantitative single photon emission tomography: verification for sources in an elliptical water phantom. Eur J Nucl Med. 1992; 19(10):838-44. PMID: 1451697.
      Citations: 1     Fields:    Translation:Humans
    140. King MA, Long DT, Brill AB. SPECT volume quantitation: influence of spatial resolution, source size and shape, and voxel size. Med Phys. 1991 Sep-Oct; 18(5):1016-24. PMID: 1961141.
      Citations: 16     Fields:    Translation:Humans
    141. King MA, Coleman M, Penney BC, Glick SJ. Activity quantitation in SPECT: a study of prereconstruction Metz filtering and use of the scatter degradation factor. Med Phys. 1991 Mar-Apr; 18(2):184-9. PMID: 2046603.
      Citations: 7     Fields:    Translation:HumansCells
    142. Glick SJ, King MA, Knesaurek K. An investigation of the 3D modulation transfer function used in 3D post-reconstruction restoration filtering of SPECT imaging. Prog Clin Biol Res. 1991; 363:107-22. PMID: 1988967.
      Citations:    Fields:    Translation:Cells
    143. Long DT, King MA, Penney BC. 2D vs. 3D edge detection as a basis for volume quantitation in SPECT. Prog Clin Biol Res. 1991; 363:457-71. PMID: 1988994.
      Citations: 1     Fields:    
    144. King MA, Glick SJ, Penney BC. Activity quantitation in SPECT: A comparison of three attenuation correction methods in combination with pre reconstruction restoration filtering. IEEE Trans Nucl Sci 38. 1991; 38:755-760.
    145. Glick SJ, Penney BC, King MA. Filtering of SPECT reconstructions made using Bellini's attenuation correction method: A comparison of three pre reconstruction filters and a post reconstruction Wiener filter. IEEE Trans Nucl Sci. 1991; 38:663-669.
    146. Penney BC, King MA, Knesaurek K. A projector, back projector, pair which accounts for the two dimensional depth and distance dependent blurring in SPECT. IEEE Trans Nucl Sci. 1990; 37:681-686.
    147. Penney BC, King MA, Glick SJ. Restoration of combined conjugate images in SPECT: Comparison of a new Wiener filter and the image dependent Metz filter. IEEE Nucl Sci. 1990; 37:707-712.
    148. Stritzke P, King MA, Vaknine R, Goldsmith SJ. Deconvolution using orthogonal polynomials in nuclear medicine: a method for forming quantitative functional images from kinetic studies. IEEE Trans Med Imaging. 1990; 9(1):11-23. PMID: 18222746.
      Citations: 1     Fields:    
    149. Penney BC, Glick SJ, King MA. Relative importance of the error sources in Wiener restoration of scintigrams. IEEE Trans Med Imaging. 1990; 9(1):60-70. PMID: 18222751.
      Citations: 1     Fields:    
    150. Knesaurek K, King MA, Glick SJ, Penney BC. Investigation of causes of geometric distortion in 180 degrees and 360 degrees angular sampling in SPECT. J Nucl Med. 1989 Oct; 30(10):1666-75. PMID: 2795207.
      Citations: 14     Fields:    
    151. Cohen MB, Lake RR, Graham LS, King MA, Kling AS, Fitten LJ, O'Rear J, Bronca GA, Gan M, Servrin R, et al. Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia. J Nucl Med. 1989 Oct; 30(10):1616-20. PMID: 2795201.
      Citations:    Fields:    Translation:Humans
    152. Glick SJ, King MA, Penney BC. Characterization of the modulation transfer function of discrete filtered backprojection. IEEE Trans Med Imaging. 1989; 8(2):203-13. PMID: 18230518.
      Citations: 3     Fields:    
    153. Glick SJ, King MA, Knesaurek K, Burbank K. An investigation of the stationarity of the 3D modulation transfer function. IEEE Trans Nucl Sci. 1989; 36:973-977.
    154. Coleman M, King MA, Glick SJ, Knesaurek K, Penney BC. Investigation of the modulation transfer function and the scatter fraction in conjugate view SPECT restoration filtering. IEEE Trans Nucl Sci. 1989; 36:969-972.
    155. King MA, Coleman M, Leppo JA. Considerations for cardiac imaging with indium 111 labeled radiopharmaceuticals. J Nucl Med Tech. 1989; 17:53-57.
    156. King MA, Penney BC, Glick SJ. An image-dependent Metz filter for nuclear medicine images. J Nucl Med. 1988 Dec; 29(12):1980-9. PMID: 3264021.
      Citations: 7     Fields:    Translation:Cells
    157. Penney BC, King MA, Schwinger RB, Baker SP, Doherty PW. Modifying constrained least-squares restoration for application to single photon emission computed tomography projection images. Med Phys. 1988 May-Jun; 15(3):334-42. PMID: 3261385.
      Citations: 1     Fields:    Translation:Humans
    158. King MA, Miller TR, Doherty PW, Schwinger RB. Stationary and nonstationary spatial domain Metz filtering. Nucl Med Commun. 1988 Jan; 9(1):3-13. PMID: 3386969.
      Citations:    Fields:    Translation:Cells
    159. Graham MM, Links JM, Lewellen TK, King MA, Croft BY, Wong DF, Esser PD, Goris ML. Considerations in the purchase of a nuclear medicine computer system. J Nucl Med. 1988; 29:334-342.
    160. Penney BC, King MA, Schwinger RB, Baker SP, Stritzke P, Doherty PW. Constrained least-squares restoration of nuclear medicine images: selecting the coarseness function. Med Phys. 1987 Sep-Oct; 14(5):849-58. PMID: 3683315.
      Citations: 3     Fields:    
    161. King MA, Glick SJ, Penney BC, Schwinger RB, Doherty PW. Interactive visual optimization of SPECT pre reconstruction filtering. J Nuc Med. 1987; 28:1192-1198.
    162. King MA, Schwinger RB, Penney BC, Doherty PW, Bianco JA. Digital restoration of indium-111 and iodine-123 SPECT images with optimized Metz filters. J Nucl Med. 1986 Aug; 27(8):1327-36. PMID: 3488378.
      Citations: 9     Fields:    Translation:HumansCells
    163. Schwinger RB, Cool SL, King MA. Area weighted convolutional interpolation for data reprojection in single photon emission computed tomography. Med Phys. 1986 May-Jun; 13(3):350-3. PMID: 3487711.
      Citations: 2     Fields:    
    164. Bianco JA, Elmaleh DR, Leppo JA, King MA, Moring A, Livni E, Espinoza E, Alpert JS, Strauss HW. Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid. Eur J Nucl Med. 1986; 12(3):120-4. PMID: 3530771.
      Citations: 5     Fields:    Translation:Animals
    165. Schwinger RB, Cool SL, King MA. Area weighted convolution interpolation for data re projection in SPECT. Medical Physics. 1986; 13:350-353.
    166. King MA, Schwinger RB, Penney BC. Variation in the count-dependent Metz filter with imaging system MTF. Medical Physics. 1986; 13:139-149.
    167. King MA, Miller TR. Use of non-stationary temporal Wiener filter in nuclear medicine. Eur J Nuc Med. 1985; 10:458-461.
    168. Bianco JA, Filiberti AW, Baker SP, King MA, Nalivaika LN, Leahey D, Doherty PW, Alpert JS. Ejection fraction and heart rate determine diastolic peak filling rate at rest and during exercise. Chest. 1985; 88:107-113.
    169. King MA, Schwinger RB, Doherty PW, Penney BC. Two-dimensional filtering of SPECT images using the Metz and Wiener filters. J Nucl Med. 1984 Nov; 25(11):1234-40. PMID: 6333497.
      Citations: 27     Fields:    Translation:HumansCells
    170. King MA, Barnes GT. Exposure uniformity considerations in slit radiography. Med Phys. 1983; 10:4-9.
    171. Miller TR, Sampathkumaran KS, King MA. Rapid digital Filtering. J Nucl Med. 1983; 24:625-628.
    172. King MA, Doherty PW, Schwinger RB, Jacobs DA, Kidder R, Miller TR. Fast count dependent digital filtering of nuclear medicine images. J Nucl Med. 1983; 24:1039-1045.
    173. King MA, Doherty PW, Rosenberg R, Cool S. Array processors: An introduction to their architecture, software, and applications in nuclear medicine. J Nucl Med. 1983; 24:1072-1079.
    174. King MA, Doherty PW, Schwinger RB, Penney BC. Two dimensional filtering of SPECT images using the Metz and Wiener filters. Med Phys. 1983; 10:876-880.
    175. Raptopoulos V, Doherty PW, Goss TP, King MA, Johnson K, Gantz NM. Acute osteomyelitis: advantage of white cell scans in early detection. AJR Am J Roentgenol. 1982 Dec; 139(6):1077-82. PMID: 6216792.
      Citations: 1     Fields:    Translation:AnimalsCells
    176. King MA, Doherty PW. A computer program for reconstruction of images from a scanning gamma camera. Comp Prog in Biomed. 1982; 14:115-120.
    177. Ansell J, Parilla N, King M, Fournier L, Szymanski I, Doherty P, VanderSalm T, Cutler B. Survival of auto transfused red blood cells recovered from the surgical field during cardiovascular surgery. J Thor Card Surg. 1982; 84:387-391.
    178. Yester MV, Barnes GT, King MA. Experimental measurements of the scatter reduction obtained in mammography with a scanning multiple slit assembly. Medical Physics. 1981; 8:158-162.
    179. King MA, Weber DA, Casarett GW, Burgener FA, Corriveau O. A study of irradiated bone. Part II. changes in Tc-99m pyrophosphate bone imaging. J Nucl Med. 1980 Jan; 21(1):22-30. PMID: 6243352.
      Citations: 3     Fields:    Translation:Animals
    180. King MA, Casarett GW, Weber DA, Burgener FA, O'Mara RE, Wilson GA. A study of irradiated bone: Part III. Scintigraphic and radiographic detection of radiogenic osteosarcomas. J Nuc Med. 1980; 21:426-431.
    181. Yester MV, Barnes GT, King MA. KVp bootstrap sensitometry. Radiology. 1980; 136:785-786.
    182. King MA, Casarett GW, Weber DA. A study of irradiated bone: Part I. Histopathologic and physiologic changes. J Nuc Med. 1979; 20:1142-1149.
    183. King MA, Kilpper RW, Weber DA. A model for local accumulation of bone imaging radiopharmaceuticals. Journal of Nuclear Medicine. 1977; 18:1106-1111.
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