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Gyongyi Szabo MD, PhD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr & Beth Israel Lahey Healt
330 Brookline Ave, ST-214B
Boston MA 02215
Phone617-667-9050
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionGastroenterology


    Collapse Biography 
    Collapse education and training
    Hungarian Academy of Sciences, Budapest, , HungaryPHDImmunology
    University of Debrecen School of Medicine, Debrecen, , HungaryMDMedicine

    Collapse Overview 
    Collapse overview

    Background

    Education:

    MD, University Medical School Debrecen, Hungary
    PhD, Hungarian Academy of Sciences (Immunology/Medicine)

    Post-Graduate Training:

    Internal Medicine Residency, University of Massachusetts Medical Center Worcester, MA

    Gastroenterology and Hepatology Fellowship, Division of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA

    Current Research Activities

    Bench Research:

    Photo: Gyongyi Szabo
    1. Immune alterations induced by acute alcohol consumption: My laboratory is one of the few focusing on immunomodulation by moderate alcohol use in humans. In addition to understanding mechanisms for the increased susceptibility to infections after alcohol use, results from our investigations have relevance to decreased cardiovascular morbidity after moderate alcohol use as well as to accelerated liver disease in chronic hepatitis C virus infection. My laboratory studies changes in the interaction between accessory cells (monocytes and dendritic cells) and T lymphocytes after moderate alcohol use. The overall aim of our studies is to delineate the effect of alcohol on antigen presenting cell function and determine role of cytokine and co-stimulatory molecules leading to decreased antigen-specific T cell proliferation and impaired antimicrobial defense after alcohol use.
    2. Intracellular signaling pathways in leukocytes mediating altered cytokine production after alcohol use. We are studying intracellular signaling mechanisms leading to decreased NF- B activation in monocytic and immune cells after acute alcohol treatment in relation to signals mediated by toll-like receptors. Recent interest is to define the NF-kB-mediated intracellular mechanisms that lead to the opposite effects of acute and chronic alcohol use on pro-inflammatory cytokine production.
    3. Immune mechanisms leading to increased liver injury in HCV plus alcohol. The hypothesis is that impaired dendritic cell costimulatory activity is a pivotal defect of host response to hepatitis C infection and alcohol further reduces immunity by inhibiting maturation and functions of myeloid dendritic cells in HCV.
    4. Immunopathogenesis of liver injury in obese mice: This is a developing project to investigate the hypothesis that leptin deficient, ob/ob mice have increased susceptibility to immune-mediated liver injury in a model of Concanavalin-A or LPS-induced hepatitis. We found that in contrast to lean mice, ob/ob mice have over-activation of the NF- B signaling pathway in the liver, a mechanisms likely to contribute to increased susceptibility to liver injury. Results from these experiments have direct clinical relevance to mechanisms of liver injury in non-alcoholic steatohepatitis in human.

    Clinical Research:

    1. Immune mechanisms of increased liver injury in HCV plus alcohol: overlap with bench research project #3.
    2. Therapeutic studies in chronic hepatitis C: I am an investigator at the UMass Memorial site of the national HALT-C trial supported by NIH.
    3. Therapeutic approaches in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A clinical trial to investigate the potential therapeutic benefit of an insulin sensitizing agent in NASH is being initiated. Additional therapeutic approaches in patients with NAFLD are under development. NAFLD /NASH have recently been recognized as one of the most prevalent liver diseases in the USA, and the most common cause of cryptogenic cirrhosis.

    Research Figure

    Research Figure


    Collapse Post Docs

    Immediate opening!

    Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated.

    Please contact Dr. Szabo for details.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Morel C, Chowdhary V, Thevkar Nagesh P, Ribeiro M, Hawryluk D, Catalano D, Adorini L, Szabo G. Altered ethanol metabolism and increased oxidative stress enhance alcohol-associated liver injury in farnesoid X receptor-deficient mice. Liver Int. 2022 Jul 22. PMID: 35869657.
      Citations:    Fields:    
    2. Szabo G, Mitchell M, McClain CJ, Dasarathy S, Barton B, McCullough AJ, Nagy LE, Kroll-Desrosiers A, Tornai D, Min HA, Radaeva S, Casey L, Cuthbert J. Reply. Hepatology. 2022 Nov; 76(5):E114-E115. PMID: 35778779.
      Citations:    Fields:    
    3. Guixé-Muntet S, Biquard L, Szabo G, Dufour JF, Tacke F, Francque S, Rautou PE, Gracia-Sancho J. Review article: vascular effects of PPARs in the context of NASH. Aliment Pharmacol Ther. 2022 07; 56(2):209-223. PMID: 35661191.
      Citations:    Fields:    Translation:Humans
    4. Szabo G, Mitchell M, McClain CJ, Dasarathy S, Barton B, McCullough AJ, Nagy LE, Kroll-Desrosiers A, Tornai D, Min HA, Radaeva S, Holbein MEB, Casey L, Cuthbert J. IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis. Hepatology. 2022 10; 76(4):1058-1068. PMID: 35340032.
      Citations:    Fields:    
    5. Szabo G, Thursz M, Shah VH. Therapeutic advances in alcohol-associated hepatitis. J Hepatol. 2022 06; 76(6):1279-1290. PMID: 35589250.
      Citations:    Fields:    Translation:Humans
    6. Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Arumugam MK, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA, Kharbanda KK. Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Front Physiol. 2022; 13:831004. PMID: 35264978.
      Citations:    
    7. Helsley RN, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang EC, Banerjee R, Brown AL, Fung KK, Massey WJ, Neumann C, Orabi D, Osborn LJ, Schugar RC, McMullen MR, Bellar A, Poulsen KL, Kim A, Pathak V, Mrdjen M, Anderson JT, Willard B, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Garcia-Garcia JC, Rotroff DM, Allende DS, Wang Z, Hazen SL, Nagy LE, Brown JM. Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice. Elife. 2022 01 27; 11. PMID: 35084335.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Bala S, Babuta M, Catalano D, Saiju A, Szabo G. Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and miR-192 Expression in Human Hepatocytes. Front Cell Dev Biol. 2021; 9:787356. PMID: 35096820.
      Citations:    
    9. Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982. PMID: 34662439.
      Citations: 2     Fields:    Translation:Humans
    10. Singal AK, Kwo P, Kwong A, Liangpunsakul S, Louvet A, Mandrekar P, McClain C, Mellinger J, Szabo G, Terrault N, Thursz M, Winder GS, Kim WR, Shah VH. Research methodologies to address clinical unmet needs and challenges in alcohol-associated liver disease. Hepatology. 2022 04; 75(4):1026-1037. PMID: 34496071.
      Citations: 1     Fields:    Translation:Humans
    11. Babuta M, Szabo G. Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases. J Leukoc Biol. 2022 01; 111(1):75-92. PMID: 34755380.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. de Carvalho Ribeiro M, Szabo G. Role of the Inflammasome in Liver Disease. Annu Rev Pathol. 2022 01 24; 17:345-365. PMID: 34752711.
      Citations: 4     Fields:    Translation:Humans
    13. Bala S, Ganz M, Babuta M, Zhuang Y, Csak T, Calenda CD, Szabo G. Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH. Lab Invest. 2021 12; 101(12):1540-1549. PMID: 34453120.
      Citations: 3     Fields:    Translation:Animals
    14. Jalan R, Szabo G. New concepts and perspectives in decompensated cirrhosis. J Hepatol. 2021 07; 75 Suppl 1:S1-S2. PMID: 34039481.
      Citations: 1     Fields:    Translation:Humans
    15. Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M. Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction. J Hepatol. 2021 07; 75 Suppl 1:S49-S66. PMID: 34039492.
      Citations: 11     Fields:    Translation:Humans
    16. Cho Y, Szabo G. Two Faces of Neutrophils in Liver Disease Development and Progression. Hepatology. 2021 07; 74(1):503-512. PMID: 33314193.
      Citations: 8     Fields:    Translation:HumansCells
    17. Szabo G. Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD. Hepatology. 2021 07; 74(1):5-8. PMID: 33724502.
      Citations: 2     Fields:    Translation:HumansCells
    18. Momen-Heravi F, Catalano D, Talis A, Szabo G, Bala S. Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice. Mol Ther Nucleic Acids. 2021 Sep 03; 25:155-167. PMID: 34458001.
      Citations:    
    19. Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE. Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans. JCI Insight. 2021 02 22; 6(4). PMID: 33616081.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997. PMID: 32557728.
      Citations: 4     Fields:    Translation:Humans
    21. He Y, Hwang S, Ahmed YA, Feng D, Li N, Ribeiro M, Lafdil F, Kisseleva T, Szabo G, Gao B. Immunopathobiology and therapeutic targets related to cytokines in liver diseases. Cell Mol Immunol. 2021 01; 18(1):18-37. PMID: 33203939.
      Citations: 10     Fields:    Translation:HumansAnimals
    22. Francque S, Szabo G, Abdelmalek MF, Byrne CD, Cusi K, Dufour JF, Roden M, Sacks F, Tacke F. Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nat Rev Gastroenterol Hepatol. 2021 01; 18(1):24-39. PMID: 33093663.
      Citations: 43     Fields:    Translation:Humans
    23. Monnig MA, Lamb PS, Parra JM, Cioe PA, Martone CM, Monti PM, Szabo G. Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults. Alcohol Alcohol. 2020 Oct 20; 55(6):616-623. PMID: 32776108.
      Citations: 1     Fields:    Translation:Humans
    24. Im GY, Mellinger JL, Winters A, Aby ES, Lominadze Z, Rice J, Lucey MR, Arab JP, Goel A, Jophlin LL, Sherman CB, Parker R, Chen PH, Devuni D, Sidhu S, Dunn W, Szabo G, Singal AK, Shah VH. Provider Attitudes and Practices for Alcohol Screening, Treatment, and Education in Patients With Liver Disease: A Survey From the American Association for the Study of Liver Diseases Alcohol-Associated Liver Disease Special Interest Group. Clin Gastroenterol Hepatol. 2021 11; 19(11):2407-2416.e8. PMID: 33069880.
      Citations: 7     Fields:    Translation:Humans
    25. Lowe PP, Morel C, Ambade A, Iracheta-Vellve A, Kwiatkowski E, Satishchandran A, Furi I, Cho Y, Gyongyosi B, Catalano D, Lefebvre E, Fischer L, Seyedkazemi S, Schafer DP, Szabo G. Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations. J Neuroinflammation. 2020 Oct 09; 17(1):296. PMID: 33036616.
      Citations: 4     Fields:    Translation:AnimalsCells
    26. Tornai D, Szabo G. Emerging medical therapies for severe alcoholic hepatitis. Clin Mol Hepatol. 2020 10; 26(4):686-696. PMID: 32981291.
      Citations: 2     Fields:    Translation:Humans
    27. Bala S, Calenda CD, Catalano D, Babuta M, Kodys K, Nasser IA, Vidal B, Szabo G. Deficiency of miR-208a Exacerbates CCl4-Induced Acute Liver Injury in Mice by Activating Cell Death Pathways. Hepatol Commun. 2020 Oct; 4(10):1487-1501. PMID: 33024918.
      Citations: 6     Fields:    
    28. Dasarathy S, Mitchell MC, Barton B, McClain CJ, Szabo G, Nagy LE, Radaeva S, McCullough AJ. Design and rationale of a multicenter defeat alcoholic steatohepatitis trial: (DASH) randomized clinical trial to treat alcohol-associated hepatitis. Contemp Clin Trials. 2020 09; 96:106094. PMID: 32739495.
      Citations: 4     Fields:    Translation:Humans
    29. Al-Azzawi Y, Albo B, Fasullo M, Coukos J, Watts GJ, Tai R, Radcliffe D, Kroll-Desrosiers A, Devuni D, Szabo G. Sarcopenia is associated with longer hospital stay and multiorgan dysfunction in alcoholic hepatitis. Eur J Gastroenterol Hepatol. 2020 06; 32(6):733-738. PMID: 31834050.
      Citations: 6     Fields:    Translation:Humans
    30. Osna NA, Bhatia R, Thompson C, Batra SK, Kumar S, Cho Y, Szabo G, Molina PE, Weinman SA, Ganesan M, Kharbanda KK. Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage. Alcohol. 2020 09; 87:63-72. PMID: 32497558.
      Citations:    Fields:    Translation:Humans
    31. Lowe PP, Cho Y, Tornai D, Coban S, Catalano D, Szabo G. Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice. Alcohol Clin Exp Res. 2020 02; 44(2):567-578. PMID: 31854009.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Crabb DW, Im GY, Szabo G, Mellinger JL, Lucey MR. Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases. Hepatology. 2020 01; 71(1):306-333. PMID: 31314133.
      Citations: 103     Fields:    Translation:Humans
    33. Avila MA, Dufour JF, Gerbes AL, Zoulim F, Bataller R, Burra P, Cortez-Pinto H, Gao B, Gilmore I, Mathurin P, Moreno C, Poznyak V, Schnabl B, Szabo G, Thiele M, Thursz MR. Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting. Gut. 2020 04; 69(4):764-780. PMID: 31879281.
      Citations: 23     Fields:    Translation:Humans
    34. Szabo G. Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection. Clin Liver Dis (Hoboken). 2019 Sep; 14(3):103-106. PMID: 31632659.
      Citations:    
    35. Lucey MR, Im GY, Mellinger JL, Szabo G, Crabb DW. Introducing the 2019 American Association for the Study of Liver Diseases Guidance on Alcohol-Associated Liver Disease. Liver Transpl. 2020 01; 26(1):14-16. PMID: 31299131.
      Citations: 7     Fields:    Translation:Humans
    36. Hosseini N, Shor J, Szabo G. Alcoholic Hepatitis: A Review. Alcohol Alcohol. 2019 Jul 01; 54(4):408-416. PMID: 31219169.
      Citations: 22     Fields:    Translation:HumansCells
    37. Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol. 2019 Jun 27; 11(6):522-530. PMID: 31293720.
      Citations:    
    38. Babuta M, Furi I, Bala S, Bukong TN, Lowe P, Catalano D, Calenda C, Kodys K, Szabo G. Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease. Hepatology. 2019 12; 70(6):2123-2141. PMID: 31090940.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    39. Saha B, Tornai D, Kodys K, Adejumo A, Lowe P, McClain C, Mitchell M, McCullough A, Dasarathy S, Kroll-Desrosiers A, Barton B, Radaeva S, Szabo G. Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis. Hepatology. 2019 10; 70(4):1134-1149. PMID: 30891779.
      Citations: 26     Fields:    Translation:Humans
    40. Al-Azzawi Y, Rouanet E, Hendrix RJ, Spaho L, Malik H, Devuni D, Szabo G, Barnard G. Segmental Distribution of Hepatocellular Carcinoma Correlates with Microvascular Invasion in Liver Explants Undergoing Transplantation. J Cancer Epidemiol. 2019; 2019:8534372. PMID: 31186641.
      Citations:    
    41. Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, Iracheta-Vellve A, Adejumo A, Saha B, Calenda C, Mehta J, Lefebvre E, Vig P, Szabo G. Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. Hepatology. 2019 03; 69(3):1105-1121. PMID: 30179264.
      Citations: 42     Fields:    Translation:AnimalsCells
    42. Moreno C, Mueller S, Szabo G. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. J Hepatol. 2019 02; 70(2):273-283. PMID: 30658728.
      Citations: 36     Fields:    Translation:HumansAnimals
    43. Thursz M, Kamath PS, Mathurin P, Szabo G, Shah VH. Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study. J Hepatol. 2019 03; 70(3):521-530. PMID: 30658117.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    44. Szabo G, Kamath PS, Shah VH, Thursz M, Mathurin P. Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study. Hepatology. 2019 05; 69(5):2271-2283. PMID: 30645002.
      Citations: 27     Fields:    Translation:Humans
    45. Wang X, de Carvalho Ribeiro M, Iracheta-Vellve A, Lowe P, Ambade A, Satishchandran A, Bukong T, Catalano D, Kodys K, Szabo G. Macrophage-Specific Hypoxia-Inducible Factor-1? Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis. Hepatology. 2019 02; 69(2):545-563. PMID: 30102772.
      Citations: 21     Fields:    Translation:AnimalsCells
    46. Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018. Hepatol Commun. 2019 Feb; 3(2):305-315. PMID: 30766966.
      Citations: 7     Fields:    
    47. Tornai D, Furi I, Shen ZT, Sigalov AB, Coban S, Szabo G. Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice. Hepatol Commun. 2019 Jan; 3(1):99-115. PMID: 30619998.
      Citations: 12     Fields:    
    48. Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Cho Y, Ambade A, Szabo G. Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression. J Neuroinflammation. 2018 Oct 27; 15(1):298. PMID: 30368255.
      Citations: 28     Fields:    Translation:Animals
    49. Iracheta-Vellve A, Calenda CD, Petrasek J, Ambade A, Kodys K, Adorini L, Szabo G. FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice. Hepatol Commun. 2018 Nov; 2(11):1379-1391. PMID: 30411084.
      Citations: 24     Fields:    
    50. Bala S, Szabo G. TFEB, a master regulator of lysosome biogenesis and autophagy, is a new player in alcoholic liver disease. Dig Med Res. 2018 Sep; 1. PMID: 30450489.
      Citations:    
    51. Bajaj JS, Moreau R, Kamath PS, Vargas HE, Arroyo V, Reddy KR, Szabo G, Tandon P, Olson J, Karvellas C, Gustot T, Lai JC, Wong F. Acute-on-Chronic Liver Failure: Getting Ready for Prime Time? Hepatology. 2018 10; 68(4):1621-1632. PMID: 29689120.
      Citations: 28     Fields:    Translation:Humans
    52. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 28; 4(1):18. PMID: 30154473.
      Citations: 6     Fields:    
    53. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 16; 4(1):16. PMID: 30115921.
      Citations: 198     Fields:    Translation:Humans
    54. Bukong TN, Cho Y, Iracheta-Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D, Kodys K, Szabo G. Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. J Hepatol. 2018 Nov; 69(5):1145-1154. PMID: 30030149.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    55. Szabo G. Gut-Liver Axis Beyond the Microbiome: How the Fungal Mycobiome Contributes to Alcoholic Liver Disease. Hepatology. 2018 12; 68(6):2426-2428. PMID: 29684245.
      Citations: 6     Fields:    Translation:HumansAnimals
    56. Szabo G. More than meets the eye: Severe alcoholic hepatitis can present as acute-on-chronic liver failure. J Hepatol. 2018 08; 69(2):269-271. PMID: 29935965.
      Citations: 2     Fields:    Translation:Humans
    57. Pilli VS, Datta A, Afreen S, Catalano D, Szabo G, Majumder R. Hypoxia downregulates protein S expression. Blood. 2018 07 26; 132(4):452-455. PMID: 29784640.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    58. Satishchandran A, Szabo G. Reply. Gastroenterology. 2018 06; 154(8):2277-2278. PMID: 29750907.
      Citations:    Fields:    
    59. Saha B, Momen-Heravi F, Furi I, Kodys K, Catalano D, Gangopadhyay A, Haraszti R, Satishchandran A, Iracheta-Vellve A, Adejumo A, Shaffer SA, Szabo G. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90. Hepatology. 2018 05; 67(5):1986-2000. PMID: 29251792.
      Citations: 49     Fields:    Translation:AnimalsCells
    60. Szabo G. Women and alcoholic liver disease - warning of a silent danger. Nat Rev Gastroenterol Hepatol. 2018 05; 15(5):253-254. PMID: 29443115.
      Citations: 11     Fields:    Translation:Humans
    61. Szabo G, Brink E. Hepatology Communications: Now in pubmed central and applying for other indices. Hepatol Commun. 2018 02; 2(2):125-127. PMID: 29404518.
      Citations:    Fields:    
    62. Szabo G. Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model. Adv Exp Med Biol. 2018; 1032:71-79. PMID: 30362091.
      Citations: 2     Fields:    Translation:Animals
    63. Szabo G. Clinical Trial Design for Alcoholic Hepatitis. Semin Liver Dis. 2017 11; 37(4):332-342. PMID: 29272895.
      Citations: 8     Fields:    Translation:Humans
    64. Iracheta-Vellve A, Szabo G. IL-1? in acetaminophen toxicity: a sterile danger signal. Cell Mol Immunol. 2018 Mar; 15(3):284-285. PMID: 29151582.
      Citations:    Fields:    Translation:AnimalsCells
    65. Satishchandran A, Ambade A, Rao S, Hsueh YC, Iracheta-Vellve A, Tornai D, Lowe P, Gyongyosi B, Li J, Catalano D, Zhong L, Kodys K, Xie J, Bala S, Gao G, Szabo G. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. Gastroenterology. 2018 01; 154(1):238-252.e7. PMID: 28987423.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    66. Szabo G, Petrasek J. Gut-liver axis and sterile signals in the development of alcoholic liver disease. Alcohol Alcohol. 2017 Jul 01; 52(4):414-424. PMID: 28482064.
      Citations: 19     Fields:    Translation:Humans
    67. Gustot T, Fernandez J, Szabo G, Albillos A, Louvet A, Jalan R, Moreau R, Moreno C. Sepsis in alcohol-related liver disease. J Hepatol. 2017 11; 67(5):1031-1050. PMID: 28647569.
      Citations: 27     Fields:    Translation:Humans
    68. Szabo G, Momen-Heravi F. Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2017 Aug; 14(8):455-466. PMID: 28634412.
      Citations: 97     Fields:    Translation:HumansCells
    69. Bala S, Csak T, Kodys K, Catalano D, Ambade A, Furi I, Lowe P, Cho Y, Iracheta-Vellve A, Szabo G. Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease. J Leukoc Biol. 2017 08; 102(2):487-498. PMID: 28584078.
      Citations: 34     Fields:    Translation:AnimalsCells
    70. Furi I, Momen-Heravi F, Szabo G. Extracellular vesicle isolation: present and future. Ann Transl Med. 2017 Jun; 5(12):263. PMID: 28706931.
      Citations:    
    71. Grander C, Adolph TE, Wieser V, Lowe P, Wrzosek L, Gyongyosi B, Ward DV, Grabherr F, Gerner RR, Pfister A, Enrich B, Ciocan D, Macheiner S, Mayr L, Drach M, Moser P, Moschen AR, Perlemuter G, Szabo G, Cassard AM, Tilg H. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut. 2018 05; 67(5):891-901. PMID: 28550049.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    72. Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Liver Int. 2017 07; 37(7):968-973. PMID: 28345165.
      Citations: 12     Fields:    Translation:AnimalsCells
    73. Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Ambade A, Kodys K, Catalano D, Ward DV, Szabo G. Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. PLoS One. 2017; 12(3):e0174544. PMID: 28350851.
      Citations: 44     Fields:    Translation:AnimalsCells
    74. Szabo G. Introducing Hepatology Communications. Hepatol Commun. 2017 Feb; 1(1):5-6. PMID: 29404428.
      Citations:    Fields:    
    75. Saha B, Kodys K, Adejumo A, Szabo G. Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes. J Immunol. 2017 03 01; 198(5):1974-1984. PMID: 28122964.
      Citations: 21     Fields:    Translation:HumansCells
    76. Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G. Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. J Biol Chem. 2016 Dec 23; 291(52):26794-26805. PMID: 27810900.
      Citations: 50     Fields:    Translation:AnimalsCells
    77. Ambade A, Satishchandran A, Saha B, Gyongyosi B, Lowe P, Kodys K, Catalano D, Szabo G. Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1?induced IL-10. Oncoimmunology. 2016; 5(10):e1221557. PMID: 27853646.
      Citations: 37     Fields:    
    78. Bukong TN, Iracheta-Vellve A, Saha B, Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Catalano D, Kodys K, Szabo G. Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease. Hepatology. 2016 10; 64(4):1057-71. PMID: 27302565.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    79. Bukong TN, Iracheta-Vellve A, Gyongyosi B, Ambade A, Catalano D, Kodys K, Szabo G. Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice. Alcohol Clin Exp Res. 2016 07; 40(7):1524-30. PMID: 27177528.
      Citations: 12     Fields:    Translation:Animals
    80. Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Szabo G. Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease. World J Gastroenterol. 2016 Apr 28; 22(16):4091-108. PMID: 27122661.
      Citations: 19     Fields:    Translation:AnimalsCells
    81. Tilg H, Moschen AR, Szabo G. Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2016 09; 64(3):955-65. PMID: 26773297.
      Citations: 107     Fields:    Translation:HumansAnimals
    82. Crabb DW, Bataller R, Chalasani NP, Kamath PS, Lucey M, Mathurin P, McClain C, McCullough A, Mitchell MC, Morgan TR, Nagy L, Radaeva S, Sanyal A, Shah V, Szabo G. Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia. Gastroenterology. 2016 Apr; 150(4):785-90. PMID: 26921783.
      Citations: 125     Fields:    Translation:Humans
    83. Ambade A, Satishchandran A, Szabo G. Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1? activation. Sci Rep. 2016 Feb 18; 6:21340. PMID: 26888602.
      Citations: 39     Fields:    Translation:AnimalsCells
    84. Bala S, Csak T, Saha B, Zatsiorsky J, Kodys K, Catalano D, Satishchandran A, Szabo G. The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis. J Hepatol. 2016 06; 64(6):1378-87. PMID: 26867493.
      Citations: 95     Fields:    Translation:AnimalsCells
    85. Szabo G, Csak T. Role of MicroRNAs in NAFLD/NASH. Dig Dis Sci. 2016 May; 61(5):1314-24. PMID: 26769057.
      Citations: 27     Fields:    Translation:Humans
    86. Saha B, Kodys K, Szabo G. Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-?. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):302-316.e8. PMID: 28090562.
      Citations: 28     Fields:    
    87. Saha B, Momen-Heravi F, Kodys K, Szabo G. MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages. J Biol Chem. 2016 Jan 01; 291(1):149-59. PMID: 26527689.
      Citations: 93     Fields:    Translation:HumansCells
    88. Momen-Heravi F, Saha B, Kodys K, Catalano D, Satishchandran A, Szabo G. Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis. J Transl Med. 2015 Aug 12; 13:261. PMID: 26264599.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    89. Szabo G, Iracheta-Vellve A. Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S18-23. PMID: 26216030.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    90. Iracheta-Vellve A, Petrasek J, Satishchandran A, Gyongyosi B, Saha B, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. J Hepatol. 2015 Nov; 63(5):1147-55. PMID: 26100496.
      Citations: 49     Fields:    Translation:AnimalsCells
    91. Ganz M, Bukong TN, Csak T, Saha B, Park JK, Ambade A, Kodys K, Szabo G. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med. 2015 Jun 16; 13:193. PMID: 26077675.
      Citations: 41     Fields:    Translation:AnimalsCells
    92. Szabo G, Petrasek J. Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol. 2015 Jul; 12(7):387-400. PMID: 26055245.
      Citations: 201     Fields:    Translation:HumansAnimals
    93. Csak T, Bala S, Lippai D, Kodys K, Catalano D, Iracheta-Vellve A, Szabo G. MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS One. 2015; 10(6):e0129251. PMID: 26042593.
      Citations: 40     Fields:    Translation:AnimalsCells
    94. Bala S, Csak T, Momen-Heravi F, Lippai D, Kodys K, Catalano D, Satishchandran A, Ambros V, Szabo G. Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep. 2015 May 29; 5:10721. PMID: 26024046.
      Citations: 60     Fields:    Translation:AnimalsCells
    95. Sanyal AJ, Gao B, Szabo G. Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis. Gastroenterology. 2015 Jul; 149(1):4-9. PMID: 26008859.
      Citations: 10     Fields:    Translation:Humans
    96. Momen-Heravi F, Bala S, Kodys K, Szabo G. Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci Rep. 2015 May 14; 5:9991. PMID: 25973575.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    97. Petrasek J, Iracheta-Vellve A, Saha B, Satishchandran A, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol. 2015 Aug; 98(2):249-56. PMID: 25934928.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    98. Saha B, Bala S, Hosseini N, Kodys K, Szabo G. Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease. J Leukoc Biol. 2015 May; 97(5):963-973. PMID: 25740962.
      Citations: 16     Fields:    
    99. Saha B, Bruneau JC, Kodys K, Szabo G. Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes. J Immunol. 2015 Apr 01; 194(7):3079-87. PMID: 25716995.
      Citations: 41     Fields:    Translation:HumansCells
    100. Szabo G, Satishchandran A. MicroRNAs in alcoholic liver disease. Semin Liver Dis. 2015 Feb; 35(1):36-42. PMID: 25632933.
      Citations: 25     Fields:    Translation:HumansCells
    101. Szabo G, Saha B, Bukong TN. Alcohol and HCV: implications for liver cancer. Adv Exp Med Biol. 2015; 815:197-216. PMID: 25427909.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    102. Szabo G, Saha B. Alcohol's Effect on Host Defense. Alcohol Res. 2015; 37(2):159-70. PMID: 26695755.
      Citations: 130     Fields:    Translation:Humans
    103. Kolls JK, Szabo G. The genetics of hepatitis C virus underlie its ability to escape humoral immunity. J Clin Invest. 2015 Jan; 125(1):97-8. PMID: 25500881.
      Citations: 4     Fields:    Translation:HumansCells
    104. Szabo G. Gut-liver axis in alcoholic liver disease. Gastroenterology. 2015 Jan; 148(1):30-6. PMID: 25447847.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    105. Bukong TN, Momen-Heravi F, Kodys K, Bala S, Szabo G. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog. 2014 Oct; 10(10):e1004424. PMID: 25275643.
      Citations: 185     Fields:    Translation:HumansCells
    106. Bukong TN, Kodys K, Szabo G. A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry. Int J Pept Res Ther. 2014 Sep; 20(3):269-276. PMID: 25379035.
      Citations:    
    107. Lippai D, Bala S, Catalano D, Kodys K, Szabo G. Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice. Alcohol Clin Exp Res. 2014 Aug; 38(8):2217-24. PMID: 25156614.
      Citations: 46     Fields:    Translation:Animals
    108. Csak T, Bala S, Lippai D, Satishchandran A, Catalano D, Kodys K, Szabo G. microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis. Liver Int. 2015 Feb; 35(2):532-41. PMID: 25040043.
      Citations: 57     Fields:    Translation:AnimalsCells
    109. Ganz M, Csak T, Szabo G. High fat diet feeding results in gender specific steatohepatitis and inflammasome activation. World J Gastroenterol. 2014 Jul 14; 20(26):8525-34. PMID: 25024607.
      Citations: 45     Fields:    Translation:Animals
    110. Saha B, Szabo G. Innate immune cell networking in hepatitis C virus infection. J Leukoc Biol. 2014 Nov; 96(5):757-66. PMID: 25001860.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    111. Bala S, Marcos M, Gattu A, Catalano D, Szabo G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One. 2014; 9(5):e96864. PMID: 24828436.
      Citations: 134     Fields:    Translation:Humans
    112. Csak T, Pillai A, Ganz M, Lippai D, Petrasek J, Park JK, Kodys K, Dolganiuc A, Kurt-Jones EA, Szabo G. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Liver Int. 2014 Oct; 34(9):1402-13. PMID: 24650018.
      Citations: 29     Fields:    Translation:AnimalsCells
    113. Momen-Heravi F, Bala S, Bukong T, Szabo G. Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. Nanomedicine. 2014 Oct; 10(7):1517-27. PMID: 24685946.
      Citations: 94     Fields:    Translation:AnimalsCells
    114. Szabo G, Lippai D. Converging actions of alcohol on liver and brain immune signaling. Int Rev Neurobiol. 2014; 118:359-80. PMID: 25175869.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    115. Petrasek J, Iracheta-Vellve A, Csak T, Satishchandran A, Kodys K, Kurt-Jones EA, Fitzgerald KA, Szabo G. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16544-9. PMID: 24052526.
      Citations: 152     Fields:    Translation:AnimalsCells
    116. Bukong TN, Kodys K, Szabo G. Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection. Hepatology. 2013 Nov; 58(5):1569-79. PMID: 23703860.
      Citations: 16     Fields:    Translation:HumansCells
    117. Ganz M, Szabo G. Immune and inflammatory pathways in NASH. Hepatol Int. 2013 Dec; 7 Suppl 2:771-81. PMID: 24587847.
      Citations: 72     Fields:    
    118. Lippai D, Bala S, Csak T, Kurt-Jones EA, Szabo G. Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice. PLoS One. 2013; 8(8):e70945. PMID: 23951048.
      Citations: 63     Fields:    Translation:AnimalsCells
    119. Petrasek J, Csak T, Ganz M, Szabo G. Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:93-8. PMID: 23855302.
      Citations: 16     Fields:    Translation:HumansCells
    120. Cabrera R, Szabo G. Another armed CD4(+) T cell ready to battle hepatocellular carcinoma. Hepatology. 2013 Jul; 58(1):1-3. PMID: 23475554.
      Citations: 4     Fields:    Translation:HumansCells
    121. Szabo G, Bala S. Reply: To PMID 22684891. Hepatology. 2013 Jun; 57(6):2547. PMID: 23112144.
      Citations: 2     Fields:    Translation:AnimalsCells
    122. Szabo G, Bala S. MicroRNAs in liver disease. Nat Rev Gastroenterol Hepatol. 2013 Sep; 10(9):542-52. PMID: 23689081.
      Citations: 259     Fields:    Translation:Humans
    123. Zhang S, Saha B, Kodys K, Szabo G. IFN-? production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells. J Hepatol. 2013 Sep; 59(3):442-9. PMID: 23665181.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    124. Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G. Alcohol-induced IL-1? in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol. 2013 Jul; 94(1):171-82. PMID: 23625200.
      Citations: 91     Fields:    Translation:AnimalsCells
    125. Shukla SD, Pruett SB, Szabo G, Arteel GE. Binge ethanol and liver: new molecular developments. Alcohol Clin Exp Res. 2013 Apr; 37(4):550-7. PMID: 23347137.
      Citations: 33     Fields:    Translation:HumansAnimals
    126. Zhang S, Kodys K, Babcock GJ, Szabo G. CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha. Hepatology. 2013 Sep; 58(3):940-9. PMID: 22577054.
      Citations: 25     Fields:    Translation:HumansCells
    127. Bukong TN, Hou W, Kodys K, Szabo G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology. 2013 Jan; 57(1):70-80. PMID: 22898980.
      Citations: 23     Fields:    Translation:HumansCells
    128. Petrasek J, Csak T, Szabo G. Toll-like receptors in liver disease. Adv Clin Chem. 2013; 59:155-201. PMID: 23461136.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    129. Hou W, Bukong TN, Kodys K, Szabo G. Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells. Alcohol Clin Exp Res. 2013 Apr; 37(4):599-608. PMID: 23126531.
      Citations: 23     Fields:    Translation:HumansCells
    130. Zhang S, Kodys K, Li K, Szabo G. Human type 2 myeloid dendritic cells produce interferon-? and amplify interferon-? in response to hepatitis C virus infection. Gastroenterology. 2013 Feb; 144(2):414-425.e7. PMID: 23089201.
      Citations: 56     Fields:    Translation:HumansCells
    131. Szabo G, Petrasek J, Bala S. Innate immunity and alcoholic liver disease. Dig Dis. 2012; 30 Suppl 1:55-60. PMID: 23075869.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    132. Dolganiuc A, Kodys K, Marshall C, Saha B, Zhang S, Bala S, Szabo G. Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells. PLoS One. 2012; 7(10):e44915. PMID: 23071503.
      Citations: 33     Fields:    Translation:HumansCells
    133. Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, Barrieau M, Min SY, Kurt-Jones EA, Szabo G. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct; 122(10):3476-89. PMID: 22945633.
      Citations: 274     Fields:    Translation:AnimalsCells
    134. Morin TJ, Broering TJ, Leav BA, Blair BM, Rowley KJ, Boucher EN, Wang Y, Cheslock PS, Knauber M, Olsen DB, Ludmerer SW, Szabo G, Finberg RW, Purcell RH, Lanford RE, Ambrosino DM, Molrine DC, Babcock GJ. Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. PLoS Pathog. 2012; 8(8):e1002895. PMID: 22952447.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    135. Bala S, Tilahun Y, Taha O, Alao H, Kodys K, Catalano D, Szabo G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med. 2012 Jul 30; 10:151. PMID: 22846613.
      Citations: 64     Fields:    Translation:HumansCells
    136. Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K, Szabo G. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology. 2012 Nov; 56(5):1946-57. PMID: 22684891.
      Citations: 288     Fields:    Translation:AnimalsCells
    137. Bala S, Tang A, Catalano D, Petrasek J, Taha O, Kodys K, Szabo G. Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance. J Leukoc Biol. 2012 Sep; 92(3):611-20. PMID: 22782967.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    138. Szabo G, Lippai D. Molecular hepatic carcinogenesis: impact of inflammation. Dig Dis. 2012; 30(3):243-8. PMID: 22722548.
      Citations: 8     Fields:    Translation:HumansCells
    139. Ward J, Bala S, Petrasek J, Szabo G. Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. World J Gastroenterol. 2012 Jun 14; 18(22):2798-804. PMID: 22719188.
      Citations: 11     Fields:    Translation:Animals
    140. Morishima C, Shiffman ML, Dienstag JL, Lindsay KL, Szabo G, Everson GT, Lok AS, Di Bisceglie AM, Ghany MG, Naishadham D, Morgan TR, Wright EC. Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C. Am J Gastroenterol. 2012 Sep; 107(9):1388-98. PMID: 22688849.
      Citations: 7     Fields:    Translation:Humans
    141. Szabo G, Csak T. Inflammasomes in liver diseases. J Hepatol. 2012 Sep; 57(3):642-54. PMID: 22634126.
      Citations: 182     Fields:    Translation:HumansCells
    142. Szabo G, Sarnow P, Bala S. MicroRNA silencing and the development of novel therapies for liver disease. J Hepatol. 2012 Aug; 57(2):462-6. PMID: 22504335.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    143. Levin I, Petrasek J, Szabo G. The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis. Alcohol Clin Exp Res. 2012 Aug; 36(8):1397-406. PMID: 22376231.
      Citations: 6     Fields:    Translation:AnimalsCells
    144. Nath B, Szabo G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology. 2012 Feb; 55(2):622-33. PMID: 22120903.
      Citations: 104     Fields:    Translation:HumansAnimals
    145. Bukong TN, Lo T, Szabo G, Dolganiuc A. Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes. Liver Int. 2012 May; 32(5):732-41. PMID: 22292891.
      Citations: 8     Fields:    Translation:HumansCells
    146. Bala S, Szabo G. MicroRNA Signature in Alcoholic Liver Disease. Int J Hepatol. 2012; 2012:498232. PMID: 22518321.
      Citations:    
    147. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011 Dec; 54(6):2185-97. PMID: 21826694.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    148. Ward J, Szabo G, McManus D, Boyer E. Advanced molecular biologic techniques in toxicologic disease. J Med Toxicol. 2011 Dec; 7(4):288-94. PMID: 22072091.
      Citations: 1     Fields:    Translation:Humans
    149. Ganz M, Csak T, Nath B, Szabo G. Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver. World J Gastroenterol. 2011 Nov 21; 17(43):4772-8. PMID: 22147977.
      Citations: 52     Fields:    Translation:Animals
    150. Pang M, Bala S, Kodys K, Catalano D, Szabo G. Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011 Sep 30; 12:55. PMID: 21962237.
      Citations: 25     Fields:    Translation:HumansCells
    151. Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 2011 Jul; 54(1):133-44. PMID: 21488066.
      Citations: 257     Fields:    Translation:AnimalsCells
    152. Dienstag JL, Ghany MG, Morgan TR, Di Bisceglie AM, Bonkovsky HL, Kim HY, Seeff LB, Szabo G, Wright EC, Sterling RK, Everson GT, Lindsay KL, Lee WM, Lok AS, Morishima C, Stoddard AM, Everhart JE. A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C. Hepatology. 2011 Aug; 54(2):396-405. PMID: 21520194.
      Citations: 53     Fields:    Translation:Humans
    153. Szabo G, Zakhari S. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients. World J Gastroenterol. 2011 May 28; 17(20):2500-6. PMID: 21633654.
      Citations: 14     Fields:    Translation:Humans
    154. Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270. PMID: 21789039.
      Citations:    
    155. Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S, Lippai D, Szabo G. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology. 2011 Jun; 53(6):1917-31. PMID: 21425308.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    156. Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D, Mandrekar P, Szabo G. Hepatocyte-specific hypoxia-inducible factor-1? is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology. 2011 May; 53(5):1526-37. PMID: 21520168.
      Citations: 95     Fields:    Translation:AnimalsCells
    157. Szabo G, Bala S, Petrasek J, Gattu A. Gut-liver axis and sensing microbes. Dig Dis. 2010; 28(6):737-44. PMID: 21525758.
      Citations: 71     Fields:    Translation:HumansAnimals
    158. Dolganiuc A, Szabo G. Dendritic cells in hepatitis C infection: can they (help) win the battle? J Gastroenterol. 2011 Apr; 46(4):432-47. PMID: 21327958.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    159. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. PMID: 21252049.
      Citations: 105     Fields:    Translation:HumansCells
    160. Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, Lippai D, Catalano D, Mandrekar P, Dolganiuc A, Kurt-Jones E, Szabo G. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Mar; 300(3):G433-41. PMID: 21233280.
      Citations: 109     Fields:    Translation:AnimalsCells
    161. Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, Kodys K, Catalano D, Kurt-Jones E, Mandrekar P, Szabo G. Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology. 2011 Feb; 53(2):649-60. PMID: 21274885.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    162. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011 Jan 14; 286(2):1436-44. PMID: 21062749.
      Citations: 195     Fields:    Translation:AnimalsCells
    163. Nath B, Li Y, Carroll JE, Szabo G, Tseng JF, Shah SA. Alcohol exposure as a risk factor for adverse outcomes in elective surgery. J Gastrointest Surg. 2010 Nov; 14(11):1732-41. PMID: 20839071.
      Citations: 25     Fields:    Translation:Humans
    164. Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology. 2011 Feb; 140(2):697-708.e4. PMID: 20727895.
      Citations: 57     Fields:    Translation:AnimalsCells
    165. Petrasek J, Mandrekar P, Szabo G. Toll-like receptors in the pathogenesis of alcoholic liver disease. Gastroenterol Res Pract. 2010; 2010. PMID: 20827314.
      Citations:    
    166. Szabo G. The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: the impact on liver disease. Hepatology. 2010 Jul; 52(1):10-2. PMID: 20578124.
      Citations: 1     Fields:    Translation:Humans
    167. Szabo G, Bala S. Alcoholic liver disease and the gut-liver axis. World J Gastroenterol. 2010 Mar 21; 16(11):1321-9. PMID: 20238398.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    168. Fontana RJ, Sanyal AJ, Ghany MG, Lee WM, Reid AE, Naishadham D, Everson GT, Kahn JA, Di Bisceglie AM, Szabo G, Morgan TR, Everhart JE. Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C. Gastroenterology. 2010 Jun; 138(7):2321-31, 2331.e1-2. PMID: 20211180.
      Citations: 12     Fields:    Translation:Humans
    169. Szabo G, Wands JR, Eken A, Osna NA, Weinman SA, Machida K, Joe Wang H. Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res. 2010 Oct; 34(10):1675-86. PMID: 20608905.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    170. Chang S, Kodys K, Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology. 2010 Jan; 51(1):35-42. PMID: 19821521.
      Citations: 31     Fields:    Translation:HumansCells
    171. Szabo G, Mandrekar P. Focus on: Alcohol and the liver. Alcohol Res Health. 2010; 33(1-2):87-96. PMID: 23579939.
      Citations: 14     Fields:    Translation:HumansAnimals
    172. Bala S, Marcos M, Szabo G. Emerging role of microRNAs in liver diseases. World J Gastroenterol. 2009 Dec 07; 15(45):5633-40. PMID: 19960558.
      Citations: 63     Fields:    Translation:HumansCells
    173. Broering TJ, Garrity KA, Boatright NK, Sloan SE, Sandor F, Thomas WD, Szabo G, Finberg RW, Ambrosino DM, Babcock GJ. Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus. J Virol. 2009 Dec; 83(23):12473-82. PMID: 19759151.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    174. Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res. 2009 Oct; 33(10):1704-10. PMID: 19572984.
      Citations: 87     Fields:    Translation:Animals
    175. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol. 2009 Jul 15; 183(2):1320-7. PMID: 19561104.
      Citations: 109     Fields:    Translation:HumansCells
    176. Nath B, Szabo G. Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity. Semin Liver Dis. 2009 May; 29(2):166-77. PMID: 19387916.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    177. Mandrekar P, Szabo G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol. 2009 Jun; 50(6):1258-66. PMID: 19398236.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    178. Dolganiuc A, Szabo G. In vitro and in vivo models of acute alcohol exposure. World J Gastroenterol. 2009 Mar 14; 15(10):1168-77. PMID: 19291816.
      Citations: 28     Fields:    Translation:HumansAnimals
    179. Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, Mandrekar P, Szabo G. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology. 2009 Mar; 49(3):989-97. PMID: 19115316.
      Citations: 101     Fields:    Translation:AnimalsCells
    180. Szabo G. The "health" and future of the physician-scientist in hepatology. Hepatology. 2009 Feb; 49(2):341-3. PMID: 19177488.
      Citations:    Fields:    Translation:Humans
    181. Lau AH, Szabo G, Thomson AW. Antigen-presenting cells under the influence of alcohol. Trends Immunol. 2009 Jan; 30(1):13-22. PMID: 19059005.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    182. Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res. 2009 Feb; 33(2):220-32. PMID: 19053973.
      Citations: 157     Fields:    Translation:HumansAnimals
    183. Hritz I, Velayudham A, Dolganiuc A, Kodys K, Mandrekar P, Kurt-Jones E, Szabo G. Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion. Hepatology. 2008 Oct; 48(4):1342-7. PMID: 18798338.
      Citations: 17     Fields:    Translation:AnimalsCells
    184. Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology. 2008 Oct; 48(4):1224-31. PMID: 18792393.
      Citations: 201     Fields:    Translation:AnimalsCells
    185. Dolganiuc A, Paek E, Kodys K, Thomas J, Szabo G. Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes. Gastroenterology. 2008 Dec; 135(6):2119-27. PMID: 18835391.
      Citations: 24     Fields:    Translation:HumansCells
    186. Szabo G, Dolganiuc A. Hepatitis C and innate immunity: recent advances. Clin Liver Dis. 2008 Aug; 12(3):675-92, x. PMID: 18625434.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    187. Norkina O, Dolganiuc A, Catalano D, Kodys K, Mandrekar P, Syed A, Efros M, Szabo G. Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes. Alcohol Clin Exp Res. 2008 Sep; 32(9):1565-73. PMID: 18616672.
      Citations: 42     Fields:    Translation:HumansCells
    188. Dolganiuc A, Szabo G. T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't. J Leukoc Biol. 2008 Sep; 84(3):614-22. PMID: 18495782.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    189. Seeff LB, Curto TM, Szabo G, Everson GT, Bonkovsky HL, Dienstag JL, Shiffman ML, Lindsay KL, Lok AS, Di Bisceglie AM, Lee WM, Ghany MG. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Hepatology. 2008 Feb; 47(2):605-12. PMID: 18157835.
      Citations: 57     Fields:    Translation:Humans
    190. Szabo G, Mandrekar P. Human monocytes, macrophages, and dendritic cells: alcohol treatment methods. Methods Mol Biol. 2008; 447:113-24. PMID: 18369915.
      Citations: 11     Fields:    Translation:HumansCells
    191. Szabo G, Dolganiuc A. The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity. Crit Rev Immunol. 2008; 28(1):61-94. PMID: 18298384.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    192. Szabo G, Dolganiuc A. Hepatitis C core protein - the "core" of immune deception? J Hepatol. 2008 Jan; 48(1):8-11. PMID: 18023495.
      Citations: 5     Fields:    Translation:HumansCells
    193. Szabo G, Mandrekar P, Dolganiuc A. Innate immune response and hepatic inflammation. Semin Liver Dis. 2007 Nov; 27(4):339-50. PMID: 17979071.
      Citations: 77     Fields:    Translation:HumansAnimals
    194. Szabo G, Chang S, Dolganiuc A. Altered innate immunity in chronic hepatitis C infection: cause or effect? Hepatology. 2007 Oct; 46(4):1279-90. PMID: 17886338.
      Citations: 20     Fields:    Translation:HumansCells
    195. Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C, Mandrekar P, Szabo G. Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology. 2007 Nov; 133(5):1627-36. PMID: 17916356.
      Citations: 93     Fields:    Translation:HumansCells
    196. Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol. 2007 Sep; 82(3):479-87. PMID: 17595379.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    197. Szabo G, Mandrekar P, Oak S, Mayerle J. Effect of ethanol on inflammatory responses. Implications for pancreatitis. Pancreatology. 2007; 7(2-3):115-23. PMID: 17592223.
      Citations: 26     Fields:    Translation:HumansCells
    198. Mandrekar P, Jeliazkova V, Catalano D, Szabo G. Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes. J Immunol. 2007 Jun 15; 178(12):7686-93. PMID: 17548605.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    199. Norkina O, Dolganiuc A, Shapiro T, Kodys K, Mandrekar P, Szabo G. Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J Leukoc Biol. 2007 Sep; 82(3):752-62. PMID: 17575268.
      Citations: 40     Fields:    Translation:HumansCells
    200. Davis GL, Krawczynski K, Szabo G. Hepatitis C virus infection--pathobiology and implications for new therapeutic options. Dig Dis Sci. 2007 Apr; 52(4):857-75. PMID: 17333350.
      Citations:    Fields:    Translation:HumansAnimalsCells
    201. Szabo G, Dolganiuc A, Dai Q, Pruett SB. TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects. J Immunol. 2007 Feb 01; 178(3):1243-9. PMID: 17237368.
      Citations: 71     Fields:    Translation:HumansCells
    202. Dolganiuc A, Chang S, Kodys K, Mandrekar P, Bakis G, Cormier M, Szabo G. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol. 2006 Nov 15; 177(10):6758-68. PMID: 17082589.
      Citations: 100     Fields:    Translation:HumansCells
    203. Szabo G, Dolganiuc A. HCV immunopathogenesis: virus-induced strategies against host immunity. Clin Liver Dis. 2006 Nov; 10(4):753-71. PMID: 17164116.
      Citations: 4     Fields:    Translation:HumansCells
    204. Brown LA, Cook RT, Jerrells TR, Kolls JK, Nagy LE, Szabo G, Wands JR, Kovacs EJ. Acute and chronic alcohol abuse modulate immunity. Alcohol Clin Exp Res. 2006 Sep; 30(9):1624-31. PMID: 16930226.
      Citations: 31     Fields:    Translation:HumansAnimals
    205. Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G. Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol. 2006 Aug 15; 177(4):2592-600. PMID: 16888021.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    206. Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology. 2006 Aug; 44(2):287-98. PMID: 16871558.
      Citations: 77     Fields:    Translation:HumansAnimals
    207. Velayudham A, Hritz I, Dolganiuc A, Mandrekar P, Kurt-Jones E, Szabo G. Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. J Hepatol. 2006 Dec; 45(6):813-24. PMID: 16935388.
      Citations: 22     Fields:    Translation:Animals
    208. Oak S, Mandrekar P, Catalano D, Kodys K, Szabo G. TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J Immunol. 2006 Jun 15; 176(12):7628-35. PMID: 16751410.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    209. Romics L, Szabo G, Coffey JC, Wang JH, Redmond HP. The emerging role of toll-like receptor pathways in surgical diseases. Arch Surg. 2006 Jun; 141(6):595-601. PMID: 16785361.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    210. Spies C, Eggers V, Szabo G, Lau A, von Dossow V, Schoenfeld H, Althoff H, Hegenscheid K, Bohm B, Schroeder T, Pfeiffer S, Ziemer S, Paschen C, Klein M, Marks C, Miller P, Sander M, Wernecke KD, Achterberg E, Kaisers U, Volk HD. Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):408-14. PMID: 16728716.
      Citations: 18     Fields:    Translation:HumansCells
    211. Crews FT, Bechara R, Brown LA, Guidot DM, Mandrekar P, Oak S, Qin L, Szabo G, Wheeler M, Zou J. Cytokines and alcohol. Alcohol Clin Exp Res. 2006 Apr; 30(4):720-30. PMID: 16573591.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    212. Szabo G, Aloman C, Polyak SJ, Weinman SA, Wands J, Zakhari S. Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity. Alcohol Clin Exp Res. 2006 Apr; 30(4):709-19. PMID: 16573590.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    213. Szabo G. Hepatitis C virus NS5A protein--a master regulator? Gastroenterology. 2006 Mar; 130(3):995-9. PMID: 16530536.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    214. Dolganiuc A, Garcia C, Kodys K, Szabo G. Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection. World J Gastroenterol. 2006 Feb 28; 12(8):1198-204. PMID: 16534871.
      Citations: 29     Fields:    Translation:HumansCells
    215. Dolganiuc A, Bakis G, Kodys K, Mandrekar P, Szabo G. Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts. Alcohol Clin Exp Res. 2006 Jan; 30(1):76-85. PMID: 16433734.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    216. Mandrekar P, Catalano D, White B, Szabo G. Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10. Alcohol Clin Exp Res. 2006 Jan; 30(1):135-9. PMID: 16433741.
      Citations: 58     Fields:    Translation:HumansCells
    217. Szabo G, Velayudham A, Romics L, Mandrekar P. Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):140S-145S. PMID: 16344599.
      Citations: 69     Fields:    Translation:Animals
    218. Romics L, Dolganiuc A, Velayudham A, Kodys K, Mandrekar P, Golenbock D, Kurt-Jones E, Szabo G. Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes. J Leukoc Biol. 2005 Dec; 78(6):1255-64. PMID: 16204620.
      Citations: 12     Fields:    Translation:AnimalsCells
    219. Szabo G, Weinman SA, Gao B, Polyak SJ, Mandrekar P, Thiele GM. RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease. Alcohol Clin Exp Res. 2005 Sep; 29(9):1753-7. PMID: 16205377.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    220. Mandrekar P, Pruett S, Arteel G, Thiele G, Szabo G. RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage. Alcohol Clin Exp Res. 2005 Sep; 29(9):1744-8. PMID: 16205375.
      Citations:    Fields:    Translation:HumansAnimals
    221. Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death. Alcohol Clin Exp Res. 2005 Sep; 29(9):1749-52. PMID: 16205376.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    222. Romics L, Mandrekar P, Kodys K, Velayudham A, Drechsler Y, Dolganiuc A, Szabo G. Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression. Alcohol Clin Exp Res. 2005 Jun; 29(6):1018-26. PMID: 15976528.
      Citations: 11     Fields:    Translation:Animals
    223. Szabo G, Dolganiuc A. Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection. Immunobiology. 2005; 210(2-4):237-47. PMID: 16164031.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    224. Dolganiuc A, Oak S, Kodys K, Golenbock DT, Finberg RW, Kurt-Jones E, Szabo G. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology. 2004 Nov; 127(5):1513-24. PMID: 15521019.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    225. Romics L, Dolganiuc A, Kodys K, Drechsler Y, Oak S, Velayudham A, Mandrekar P, Szabo G. Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology. 2004 Sep; 40(3):555-64. PMID: 15349893.
      Citations: 26     Fields:    Translation:AnimalsCells
    226. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G. Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production. J Immunol. 2004 Sep 01; 173(5):3398-407. PMID: 15322204.
      Citations: 43     Fields:    Translation:HumansCells
    227. Romics L, Kodys K, Dolganiuc A, Graham L, Velayudham A, Mandrekar P, Szabo G. Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver. Hepatology. 2004 Aug; 40(2):376-85. PMID: 15368442.
      Citations: 21     Fields:    Translation:AnimalsCells
    228. Szabo G, Dolganiuc A, Mandrekar P, White B. Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection. Alcohol. 2004 Jul; 33(3):241-9. PMID: 15596093.
      Citations: 20     Fields:    Translation:HumansCells
    229. Szabo G, Catalano D, White B, Mandrekar P. Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res. 2004 May; 28(5):824-8. PMID: 15166660.
      Citations: 32     Fields:    Translation:HumansCells
    230. Dolganiuc A, Kodys K, Kopasz A, Marshall C, Mandrekar P, Szabo G. Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction. Alcohol Clin Exp Res. 2003 Jun; 27(6):1023-31. PMID: 12824825.
      Citations: 25     Fields:    Translation:HumansCells
    231. Dolganiuc A, Kodys K, Kopasz A, Marshall C, Do T, Romics L, Mandrekar P, Zapp M, Szabo G. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol. 2003 Jun 01; 170(11):5615-24. PMID: 12759441.
      Citations: 78     Fields:    Translation:HumansCells
    232. Szabo G. Pathogenic interactions between alcohol and hepatitis C. Curr Gastroenterol Rep. 2003 Feb; 5(1):86-92. PMID: 12530953.
      Citations: 7     Fields:    Translation:HumansCells
    233. Mandrekar P, Bellerose G, Szabo G. Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes. Alcohol Clin Exp Res. 2002 Dec; 26(12):1872-9. PMID: 12500112.
      Citations: 6     Fields:    Translation:HumansCells
    234. Thiele GM, Szabo G, Kovacs EJ, Bautista AP, Sosa L, Jerrells TR. Modulation of immunity and viral-host interactions by alcohol. Alcohol Clin Exp Res. 2002 Dec; 26(12):1897-908. PMID: 12500115.
      Citations: 2     Fields:    Translation:HumansAnimals
    235. Mandrekar P, Dolganiuc A, Bellerose G, Kodys K, Romics L, Nizamani R, Szabo G. Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation? Alcohol Clin Exp Res. 2002 Nov; 26(11):1609-14. PMID: 12436048.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    236. Szabo G, Romics L, Frendl G. Liver in sepsis and systemic inflammatory response syndrome. Clin Liver Dis. 2002 Nov; 6(4):1045-66, x. PMID: 12516206.
      Citations: 46     Fields:    Translation:Humans
    237. Drechsler Y, Chavan S, Catalano D, Mandrekar P, Szabo G. FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development. J Leukoc Biol. 2002 Oct; 72(4):657-67. PMID: 12377934.
      Citations: 6     Fields:    Translation:HumansCells
    238. Bonkovsky HL, Azar R, Bird S, Szabo G, Banner B. Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone. Dig Dis Sci. 2002 Jul; 47(7):1632-7. PMID: 12141828.
      Citations: 13     Fields:    Translation:Humans
    239. Szabo G, Mandrekar P. Ethanol-mediated regulation of transcription factors in immunocompetent cells. Front Biosci. 2002 May 01; 7:a80-9. PMID: 11991856.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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