Lila Gierasch to Protein Folding
This is a "connection" page, showing publications Lila Gierasch has written about Protein Folding.
Connection Strength
8.906
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Williams RV, Guay KP, Hurlbut Lesk OA, Clerico EM, Hebert DN, Gierasch LM. Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2315009121.
Score: 0.786
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Powers ET, Gierasch LM. The Proteome Folding Problem and Cellular Proteostasis. J Mol Biol. 2021 10 01; 433(20):167197.
Score: 0.638
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Mayer MP, Gierasch LM. Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones. J Biol Chem. 2019 02 08; 294(6):2085-2097.
Score: 0.528
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Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM. Ligand-promoted protein folding by biased kinetic partitioning. Nat Chem Biol. 2017 04; 13(4):369-371.
Score: 0.468
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Hingorani KS, Gierasch LM. Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge. Curr Opin Struct Biol. 2014 Feb; 24:81-90.
Score: 0.378
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Budyak IL, Zhuravleva A, Gierasch LM. The Role of Aromatic-Aromatic Interactions in Strand-Strand Stabilization of ?-Sheets. J Mol Biol. 2013 Sep 23; 425(18):3522-35.
Score: 0.363
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Budyak IL, Krishnan B, Marcelino-Cruz AM, Ferrolino MC, Zhuravleva A, Gierasch LM. Early folding events protect aggregation-prone regions of a ?-rich protein. Structure. 2013 Mar 05; 21(3):476-85.
Score: 0.356
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Powers ET, Powers DL, Gierasch LM. FoldEco: a model for proteostasis in E. coli. Cell Rep. 2012 Mar 29; 1(3):265-76.
Score: 0.333
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Gierasch LM. A career pathway in protein folding: from model peptides to postreductionist protein science. Protein Sci. 2011 May; 20(5):783-90.
Score: 0.311
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Gershenson A, Gierasch LM. Protein folding in the cell: challenges and progress. Curr Opin Struct Biol. 2011 Feb; 21(1):32-41.
Score: 0.304
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Marcelino AM, Gierasch LM. Roles of beta-turns in protein folding: from peptide models to protein engineering. Biopolymers. 2008 May; 89(5):380-91.
Score: 0.254
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Ignatova Z, Gierasch LM. Chapter 3: A fluorescent window into protein folding and aggregation in cells. Methods Cell Biol. 2008; 89:59-70.
Score: 0.248
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Ignatova Z, Gierasch LM. Effects of osmolytes on protein folding and aggregation in cells. Methods Enzymol. 2007; 428:355-72.
Score: 0.232
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Ignatova Z, Gierasch LM. Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13357-61.
Score: 0.226
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Smock RG, Gierasch LM. Finding the fittest fold: using the evolutionary record to design new proteins. Cell. 2005 Sep 23; 122(6):832-4.
Score: 0.212
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Ignatova Z, Gierasch LM. Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus. Biochemistry. 2005 May 17; 44(19):7266-74.
Score: 0.207
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Gierasch LM. From Rat Tails to Glycoproteostasis: Motivated by Biology, Enabled by Biophysics, and Lucky. J Mol Biol. 2025 06 01; 437(11):169055.
Score: 0.204
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Guay KP, Ke H, Canniff NP, George GT, Eyles SJ, Mariappan M, Contessa JN, Gershenson A, Gierasch LM, Hebert DN. ER chaperones use a protein folding and quality control glyco-code. Mol Cell. 2023 12 21; 83(24):4524-4537.e5.
Score: 0.187
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Rotondi KS, Gierasch LM. Role of local sequence in the folding of cellular retinoic abinding protein I: structural propensities of reverse turns. Biochemistry. 2003 Jul 08; 42(26):7976-85.
Score: 0.182
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Rotondi KS, Rotondi LF, Gierasch LM. Native structural propensity in cellular retinoic acid-binding protein I 64-88: the role of locally encoded structure in the folding of a beta-barrel protein. Biophys Chem. 2003; 100(1-3):421-36.
Score: 0.176
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Nordquist EB, Clerico EM, Chen J, Gierasch LM. Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future. J Phys Chem B. 2022 09 15; 126(36):6780-6791.
Score: 0.172
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Clerico EM, Pozhidaeva AK, Jansen RM, ?zden C, Tilitsky JM, Gierasch LM. Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc Natl Acad Sci U S A. 2021 10 12; 118(41).
Score: 0.161
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Gunasekaran K, Eyles SJ, Hagler AT, Gierasch LM. Keeping it in the family: folding studies of related proteins. Curr Opin Struct Biol. 2001 Feb; 11(1):83-93.
Score: 0.154
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Clerico EM, Meng W, Pozhidaeva A, Bhasne K, Petridis C, Gierasch LM. Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines. Biochem J. 2019 06 14; 476(11):1653-1677.
Score: 0.137
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Thakur AK, Meng W, Gierasch LM. Local and non-local topological information in the denatured state ensemble of a ?-barrel protein. Protein Sci. 2018 12; 27(12):2062-2072.
Score: 0.131
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Clark PL, Liu ZP, Rizo J, Gierasch LM. Cavity formation before stable hydrogen bonding in the folding of a beta-clam protein. Nat Struct Biol. 1997 Nov; 4(11):883-6.
Score: 0.123
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Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli. Cell Rep. 2015 Apr 14; 11(2):321-33.
Score: 0.103
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Liu ZP, Rizo J, Gierasch LM. Equilibrium folding studies of cellular retinoic acid binding protein, a predominantly beta-sheet protein. Biochemistry. 1994 Jan 11; 33(1):134-42.
Score: 0.094
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Landry SJ, Gierasch LM. Polypeptide interactions with molecular chaperones and their relationship to in vivo protein folding. Annu Rev Biophys Biomol Struct. 1994; 23:645-69.
Score: 0.094
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Ferrolino MC, Zhuravleva A, Budyak IL, Krishnan B, Gierasch LM. Delicate balance between functionally required flexibility and aggregation risk in a ?-rich protein. Biochemistry. 2013 Dec 10; 52(49):8843-54.
Score: 0.093
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Smock RG, Blackburn ME, Gierasch LM. Conserved, disordered C terminus of DnaK enhances cellular survival upon stress and DnaK in vitro chaperone activity. J Biol Chem. 2011 Sep 09; 286(36):31821-9.
Score: 0.079
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Hong J, Gierasch LM. Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state. J Am Chem Soc. 2010 Aug 04; 132(30):10445-52.
Score: 0.074
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Eyles SJ, Gierasch LM. Nature's molecular sponges: small heat shock proteins grow into their chaperone roles. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):2727-8.
Score: 0.072
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Hebert DN, Gierasch LM. The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner. Mol Cell. 2009 Jun 26; 34(6):635-6.
Score: 0.069
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Ignatova Z, Gierasch LM. A method for direct measurement of protein stability in vivo. Methods Mol Biol. 2009; 490:165-78.
Score: 0.067
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Ghosh RP, Horowitz-Scherer RA, Nikitina T, Gierasch LM, Woodcock CL. Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions. J Biol Chem. 2008 Jul 18; 283(29):20523-34.
Score: 0.064
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Ignatova Z, Krishnan B, Bombardier JP, Marcelino AM, Hong J, Gierasch LM. From the test tube to the cell: exploring the folding and aggregation of a beta-clam protein. Biopolymers. 2007; 88(2):157-63.
Score: 0.058
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Swain JF, Gierasch LM. First glimpses of a chaperonin-bound folding intermediate. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13715-6.
Score: 0.053
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Gunasekaran K, Hagler AT, Gierasch LM. Sequence and structural analysis of cellular retinoic acid-binding proteins reveals a network of conserved hydrophobic interactions. Proteins. 2004 Feb 01; 54(2):179-94.
Score: 0.047
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Swain JF, Gierasch LM. A new twist for an Hsp70 chaperone. Nat Struct Biol. 2002 Jun; 9(6):406-8.
Score: 0.042
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Gierasch LM. Caught in the act: how ATP binding triggers cooperative conformational changes in a molecular machine. Mol Cell. 2002 Jan; 9(1):3-5.
Score: 0.041
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Triplett TL, Sgrignoli AR, Gao FB, Yang YB, Tai PC, Gierasch LM. Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity. J Biol Chem. 2001 Jun 01; 276(22):19648-55.
Score: 0.039
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Cleverley RM, Zheng N, Gierasch LM. The cost of exposing a hydrophobic loop and implications for the functional role of 4.5 S RNA in the Escherichia coli signal recognition particle. J Biol Chem. 2001 Jun 01; 276(22):19327-31.
Score: 0.039
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Swain JF, Sivendran R, Gierasch LM. Defining the structure of the substrate-free state of the DnaK molecular chaperone. Biochem Soc Symp. 2001; (68):69-82.
Score: 0.038
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Eyles SJ, Gierasch LM. Multiple roles of prolyl residues in structure and folding. J Mol Biol. 2000 Aug 18; 301(3):737-47.
Score: 0.037
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Feltham JL, Gierasch LM. GroEL-substrate interactions: molding the fold, or folding the mold? Cell. 2000 Jan 21; 100(2):193-6.
Score: 0.036
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Pobre KFR, Powers DL, Ghosh K, Gierasch LM, Powers ET. Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment. Protein Sci. 2019 07; 28(7):1324-1339.
Score: 0.034
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Feng HP, Gierasch LM. Molecular chaperones: clamps for the Clps? Curr Biol. 1998 Jun 18; 8(13):R464-7.
Score: 0.032
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Clark PL, Liu ZP, Zhang J, Gierasch LM. Intrinsic tryptophans of CRABPI as probes of structure and folding. Protein Sci. 1996 Jun; 5(6):1108-17.
Score: 0.028
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Chandrasekhar K, Ke H, Wang N, Goodwin T, Gierasch LM, Gershenson A, Hebert DN. Cellular folding pathway of a metastable serpin. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):6484-9.
Score: 0.028
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Gershenson A, Gierasch LM, Pastore A, Radford SE. Energy landscapes of functional proteins are inherently risky. Nat Chem Biol. 2014 Nov; 10(11):884-91.
Score: 0.025
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Zhi W, Landry SJ, Gierasch LM, Srere PA. Renaturation of citrate synthase: influence of denaturant and folding assistants. Protein Sci. 1992 Apr; 1(4):522-9.
Score: 0.021
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Kabani M, Kelley SS, Morrow MW, Montgomery DL, Sivendran R, Rose MD, Gierasch LM, Brodsky JL. Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP. Mol Biol Cell. 2003 Aug; 14(8):3437-48.
Score: 0.011
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Eyles SJ, Dresch T, Gierasch LM, Kaltashov IA. Unfolding dynamics of a beta-sheet protein studied by mass spectrometry. J Mass Spectrom. 1999 Dec; 34(12):1289-95.
Score: 0.009
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Hunt JF, Weaver AJ, Landry SJ, Gierasch L, Deisenhofer J. The crystal structure of the GroES co-chaperonin at 2.8 A resolution. Nature. 1996 Jan 04; 379(6560):37-45.
Score: 0.007