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Patricia Wadsworth PhD

InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address458 Morrill Science Center IV
Amherst, MA 01003
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Verma V, Wadsworth P, Maresca TJ. Human dynein-dynactin is a fast processive motor in living cells. bioRxiv. 2023 Nov 29. PMID: 38076961.
    2. do Ros?rio CF, Zhang Y, Stadnicki J, Ross JL, Wadsworth P. Lateral and longitudinal compaction of PRC1 overlap zones drives stabilization of interzonal microtubules. Mol Biol Cell. 2023 09 01; 34(10):ar100. PMID: 37467037.
      Citations:    Fields:    Translation:HumansCells
    3. Fermino do Ros?rio C, Wadsworth P. Measurement of Microtubule Stability in Mammalian Cells. Curr Protoc. 2023 May; 3(5):e793. PMID: 37235484.
      Citations:    Fields:    Translation:AnimalsCells
    4. Velle KB, Kennard AS, Trupinic M, Ivec A, Swafford AJM, Nolton E, Rice LM, Tolic IM, Fritz-Laylin LK, Wadsworth P. Naegleria's mitotic spindles are built from unique tubulins and highlight core spindle features. Curr Biol. 2022 03 28; 32(6):1247-1261.e6. PMID: 35139359.
      Citations: 8     Fields:    Translation:AnimalsCells
    5. Velle KB, Fermino do Ros?rio C, Wadsworth P, Fritz-Laylin LK. A OneStep Solution to Fix and Stain Cells for Correlative Live and Fixed Microscopy. Curr Protoc. 2021 Nov; 1(11):e308. PMID: 34826344.
      Citations: 3     Fields:    Translation:AnimalsCells
    6. Wadsworth P. The multifunctional spindle midzone in vertebrate cells at a glance. J Cell Sci. 2021 05 15; 134(10). PMID: 34042161.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Wadsworth P. Cytoskeleton 2020 paper of the year. Cytoskeleton (Hoboken). 2021 02; 78(2):21-22. PMID: 33634565.
      Citations:    Fields:    Translation:Cells
    8. Wadsworth P. 2019 Cytoskeleton Paper of the Year: A revised order of subunits in mammalian septin complexes. Cytoskeleton (Hoboken). 2020 01; 77(1-2):3. PMID: 32011107.
      Citations:    Fields:    Translation:AnimalsCells
    9. Wadsworth P. Novel approaches for imaging the cytoskeleton. Cytoskeleton (Hoboken). 2018 12; 75(12):497. PMID: 30681299.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Mann BJ, Wadsworth P. Distribution of Eg5 and TPX2 in mitosis: Insight from CRISPR tagged cells. Cytoskeleton (Hoboken). 2018 12; 75(12):508-521. PMID: 30123975.
      Citations: 4     Fields:    Translation:HumansCells
    11. Mann BJ, Wadsworth P. Kinesin-5 Regulation and Function in Mitosis. Trends Cell Biol. 2019 01; 29(1):66-79. PMID: 30220581.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    12. Bickel KG, Mann BJ, Waitzman JS, Poor TA, Rice SE, Wadsworth P. Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5. Cytoskeleton (Hoboken). 2017 Sep; 74(9):317-330. PMID: 28646493.
      Citations: 11     Fields:    Translation:HumansCells
    13. Mann BJ, Balchand SK, Wadsworth P. Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics. Mol Biol Cell. 2017 01 01; 28(1):65-75. PMID: 27852894.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Balchand SK, Mann BJ, Wadsworth P. Using Fluorescence Microscopy to Study Mitosis. Methods Mol Biol. 2016; 1413:3-14. PMID: 27193839.
      Citations:    Fields:    
    15. Wadsworth P. TPX2. Curr Biol. 2015 Dec 21; 25(24):R1156-8. PMID: 26702647.
      Citations: 19     Fields:    Translation:Cells
    16. Balchand SK, Mann BJ, Titus J, Ross JL, Wadsworth P. TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule. J Biol Chem. 2015 Jul 10; 290(28):17367-79. PMID: 26018074.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    17. Collins E, Mann BJ, Wadsworth P. Eg5 restricts anaphase B spindle elongation in mammalian cells. Cytoskeleton (Hoboken). 2014 Feb; 71(2):136-44. PMID: 24285623.
      Citations: 22     Fields:    Translation:AnimalsCells
    18. Wadsworth P, Lee WL. Microtubule motors: doin' it without dynactin. Curr Biol. 2013 Jul 08; 23(13):R563-5. PMID: 23845243.
      Citations:    Fields:    Translation:Humans
    19. Collins ES, Balchand SK, Faraci JL, Wadsworth P, Lee WL. Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase. Mol Biol Cell. 2012 Sep; 23(17):3380-90. PMID: 22809624.
      Citations: 40     Fields:    Translation:AnimalsCells
    20. Gable A, Qiu M, Titus J, Balchand S, Ferenz NP, Ma N, Collins ES, Fagerstrom C, Ross JL, Yang G, Wadsworth P. Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2. Mol Biol Cell. 2012 Apr; 23(7):1254-66. PMID: 22337772.
      Citations: 31     Fields:    Translation:AnimalsCells
    21. Wadsworth P. Using cultured mammalian cells to study mitosis. Cold Spring Harb Protoc. 2012 Feb 01; 2012(2):205-12. PMID: 22301654.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    22. Ma N, Titus J, Gable A, Ross JL, Wadsworth P. TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J Cell Biol. 2011 Oct 03; 195(1):87-98. PMID: 21969468.
      Citations: 58     Fields:    Translation:AnimalsCells
    23. Wadsworth P, Lee WL, Murata T, Baskin TI. Variations on theme: spindle assembly in diverse cells. Protoplasma. 2011 Jul; 248(3):439-46. PMID: 20830494.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Goodson HV, Dzurisin JS, Wadsworth P. Generation of stable cell lines expressing GFP-tubulin and photoactivatable-GFP-tubulin and characterization of clones. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.prot5480. PMID: 20810628.
      Citations: 4     Fields:    Translation:Cells
    25. Goodson HV, Dzurisin JS, Wadsworth P. Methods for expressing and analyzing GFP-tubulin and GFP-microtubule-associated proteins. Cold Spring Harb Protoc. 2010 Sep 01; 2010(9):pdb.top85. PMID: 20810643.
      Citations: 12     Fields:    
    26. Ferenz NP, Gable A, Wadsworth P. Mitotic functions of kinesin-5. Semin Cell Dev Biol. 2010 May; 21(3):255-9. PMID: 20109572.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    27. Ma N, Tulu US, Ferenz NP, Fagerstrom C, Wilde A, Wadsworth P. Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Mol Biol Cell. 2010 Mar 15; 21(6):979-88. PMID: 20110350.
      Citations: 47     Fields:    Translation:AnimalsCells
    28. Ferenz NP, Ma N, Lee WL, Wadsworth P. Imaging protein dynamics in live mitotic cells. Methods. 2010 Jun; 51(2):193-6. PMID: 20085816.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    29. Tulu US, Ferenz NP, Wadsworth P. Photoactivatable green fluorescent protein-tubulin. Methods Cell Biol. 2010; 97:81-90. PMID: 20719266.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Miquelard-Garnier G, Zimberlin JA, Sikora CB, Wadsworth P, Crosby A. Polymer microlenses for quantifying cell sheet mechanics. Soft Matter. 2010 Jan 01; 6(2):398-403. PMID: 20445765.
      Citations: 2     Fields:    
    31. Ferenz NP, Paul R, Fagerstrom C, Mogilner A, Wadsworth P. Dynein antagonizes eg5 by crosslinking and sliding antiparallel microtubules. Curr Biol. 2009 Nov 17; 19(21):1833-8. PMID: 19836236.
      Citations: 51     Fields:    Translation:AnimalsCells
    32. Lee WL, Wadsworth P. New spindle morphogenesis model by Dynein, Nudel, and the spindle matrix. Cell Res. 2009 May; 19(5):529-31. PMID: 19421240.
      Citations: 1     Fields:    Translation:Cells
    33. Bezanilla M, Wadsworth P. Spindle positioning: actin mediates pushing and pulling. Curr Biol. 2009 Feb 24; 19(4):R168-9. PMID: 19243693.
      Citations: 12     Fields:    Translation:AnimalsCells
    34. Zimberlin JA, Wadsworth P, Crosby AJ. Living microlens arrays. Cell Motil Cytoskeleton. 2008 Sep; 65(9):762-7. PMID: 18615631.
      Citations: 2     Fields:    Translation:AnimalsCells
    35. Murthy K, Wadsworth P. Dual role for microtubules in regulating cortical contractility during cytokinesis. J Cell Sci. 2008 Jul 15; 121(Pt 14):2350-9. PMID: 18559890.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    36. Ferenz NP, Wadsworth P. Prophase microtubule arrays undergo flux-like behavior in mammalian cells. Mol Biol Cell. 2007 Oct; 18(10):3993-4002. PMID: 17671163.
      Citations: 17     Fields:    Translation:AnimalsCells
    37. Bannigan A, Scheible WR, Lukowitz W, Fagerstrom C, Wadsworth P, Somerville C, Baskin TI. A conserved role for kinesin-5 in plant mitosis. J Cell Sci. 2007 Aug 15; 120(Pt 16):2819-27. PMID: 17652157.
      Citations: 42     Fields:    Translation:AnimalsCells
    38. Yang Z, Tulu US, Wadsworth P, Rieder CL. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr Biol. 2007 Jun 05; 17(11):973-80. PMID: 17509882.
      Citations: 112     Fields:    Translation:HumansCells
    39. Wadsworth P. Studying mitosis in cultured Mammalian cells. CSH Protoc. 2007 Feb 01; 2007:pdb.prot4674. PMID: 21357020.
    40. Daniels R, Rusan NM, Wadsworth P, Hebert DN. SV40 VP2 and VP3 insertion into ER membranes is controlled by the capsid protein VP1: implications for DNA translocation out of the ER. Mol Cell. 2006 Dec 28; 24(6):955-66. PMID: 17189196.
      Citations: 60     Fields:    Translation:Cells
    41. Daniels R, Rusan NM, Wilbuer AK, Norkin LC, Wadsworth P, Hebert DN. Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes. J Virol. 2006 Jul; 80(13):6575-87. PMID: 16775344.
      Citations: 26     Fields:    Translation:AnimalsCells
    42. Tulu US, Fagerstrom C, Ferenz NP, Wadsworth P. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr Biol. 2006 Mar 07; 16(5):536-41. PMID: 16527751.
      Citations: 109     Fields:    Translation:AnimalsCells
    43. Wadsworth P, Rusan NM, Tulu US, Fagerstrom C. Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells. Nat Methods. 2005 Dec; 2(12):981-7. PMID: 16299485.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Wadsworth P. Cytokinesis: Rho marks the spot. Curr Biol. 2005 Nov 08; 15(21):R871-4. PMID: 16271857.
      Citations: 11     Fields:    Translation:Cells
    45. Salaycik KJ, Fagerstrom CJ, Murthy K, Tulu US, Wadsworth P. Quantification of microtubule nucleation, growth and dynamics in wound-edge cells. J Cell Sci. 2005 Sep 15; 118(Pt 18):4113-22. PMID: 16118246.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    46. Murthy K, Wadsworth P. Myosin-II-dependent localization and dynamics of F-actin during cytokinesis. Curr Biol. 2005 Apr 26; 15(8):724-31. PMID: 15854904.
      Citations: 152     Fields:    Translation:AnimalsCells
    47. Rusan NM, Wadsworth P. Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase. J Cell Biol. 2005 Jan 03; 168(1):21-8. PMID: 15631988.
      Citations: 29     Fields:    Translation:AnimalsCells
    48. Wadsworth P, Khodjakov A. E pluribus unum: towards a universal mechanism for spindle assembly. Trends Cell Biol. 2004 Aug; 14(8):413-9. PMID: 15308207.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    49. Tulu US, Rusan NM, Wadsworth P. Peripheral, non-centrosome-associated microtubules contribute to spindle formation in centrosome-containing cells. Curr Biol. 2003 Oct 28; 13(21):1894-9. PMID: 14588246.
      Citations: 55     Fields:    Translation:AnimalsCells
    50. Wadsworth P. Cell biology. Persistence pays. Science. 2003 Jun 13; 300(5626):1675-7. PMID: 12805528.
      Citations: 2     Fields:    Translation:AnimalsCells
    51. Rusan NM, Tulu US, Fagerstrom C, Wadsworth P. Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport. J Cell Biol. 2002 Sep 16; 158(6):997-1003. PMID: 12235119.
      Citations: 62     Fields:    Translation:AnimalsCells
    52. Landen JW, Lang R, McMahon SJ, Rusan NM, Yvon AM, Adams AW, Sorcinelli MD, Campbell R, Bonaccorsi P, Ansel JC, Archer DR, Wadsworth P, Armstrong CA, Joshi HC. Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 2002 Jul 15; 62(14):4109-14. PMID: 12124349.
      Citations: 54     Fields:    Translation:AnimalsCells
    53. Yvon AM, Gross DJ, Wadsworth P. Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8656-61. PMID: 11438687.
      Citations: 13     Fields:    Translation:AnimalsCells
    54. Rusan NM, Fagerstrom CJ, Yvon AM, Wadsworth P. Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin. Mol Biol Cell. 2001 Apr; 12(4):971-80. PMID: 11294900.
      Citations: 147     Fields:    Translation:AnimalsCells
    55. Yvon AM, Wadsworth P. Region-specific microtubule transport in motile cells. J Cell Biol. 2000 Nov 27; 151(5):1003-12. PMID: 11086002.
      Citations: 15     Fields:    Translation:AnimalsCells
    56. Yvon AM, Wadsworth P, Jordan MA. Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell. 1999 Apr; 10(4):947-59. PMID: 10198049.
      Citations: 200     Fields:    Translation:HumansCells
    57. Wadsworth P. Microinjection of mitotic cells. Methods Cell Biol. 1999; 61:219-31. PMID: 9891317.
      Citations: 4     Fields:    Translation:HumansAnimals
    58. Wadsworth P. Regional regulation of microtubule dynamics in polarized, motile cells. Cell Motil Cytoskeleton. 1999; 42(1):48-59. PMID: 9915584.
      Citations: 31     Fields:    Translation:AnimalsCells
    59. McMeekan J, Wadsworth P. Functional assays to identify and characterize regulators of microtubule behavior. Biotechniques. 1998 May; 24(5):870-6. PMID: 9591140.
      Citations:    Fields:    Translation:AnimalsCells
    60. Yvon AM, Wadsworth P. Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells. J Cell Sci. 1997 Oct; 110 ( Pt 19):2391-401. PMID: 9410878.
      Citations: 29     Fields:    Translation:HumansCells
    61. Wadsworth P, Bottaro DP. Microtubule dynamic turnover is suppressed during polarization and stimulated in hepatocyte growth factor scattered Madin-Darby canine kidney epithelial cells. Cell Motil Cytoskeleton. 1996; 35(3):225-36. PMID: 8913643.
      Citations: 6     Fields:    Translation:AnimalsCells
    62. Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P. Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell. 1995 Sep; 6(9):1215-29. PMID: 8534917.
      Citations: 51     Fields:    Translation:AnimalsCells
    63. Dhamodharan R, Wadsworth P. Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins. J Cell Sci. 1995 Apr; 108 ( Pt 4):1679-89. PMID: 7615685.
      Citations: 34     Fields:    Translation:AnimalsCells
    64. Hush JM, Wadsworth P, Callaham DA, Hepler PK. Quantification of microtubule dynamics in living plant cells using fluorescence redistribution after photobleaching. J Cell Sci. 1994 Apr; 107 ( Pt 4):775-84. PMID: 8056836.
      Citations: 40     Fields:    Translation:Cells
    65. Shelden E, Wadsworth P. Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific. J Cell Biol. 1993 Feb; 120(4):935-45. PMID: 8432733.
      Citations: 74     Fields:    Translation:AnimalsCells
    66. Wadsworth P. Mitosis: spindle assembly and chromosome motion. Curr Opin Cell Biol. 1993 Feb; 5(1):123-8. PMID: 8448024.
      Citations: 5     Fields:    Translation:Cells
    67. Shelden E, Wadsworth P. Microinjection of biotin-tubulin into anaphase cells induces transient elongation of kinetochore microtubules and reversal of chromosome-to-pole motion. J Cell Biol. 1992 Mar; 116(6):1409-20. PMID: 1541637.
      Citations: 12     Fields:    Translation:AnimalsCells
    68. Amin-Hanjani S, Wadsworth P. Inhibition of spindle elongation by taxol. Cell Motil Cytoskeleton. 1991; 20(2):136-44. PMID: 1684311.
      Citations: 10     Fields:    Translation:AnimalsCells
    69. Zhang D, Wadsworth P, Hepler PK. Microtubule dynamics in living dividing plant cells: confocal imaging of microinjected fluorescent brain tubulin. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8820-4. PMID: 11607116.
      Citations: 38     Fields:    
    70. Shelden E, Wadsworth P. Interzonal microtubules are dynamic during spindle elongation. J Cell Sci. 1990 Oct; 97 ( Pt 2):273-81. PMID: 2277093.
      Citations: 17     Fields:    Translation:AnimalsCells
    71. Wadsworth P, McGrail M. Interphase microtubule dynamics are cell type-specific. J Cell Sci. 1990 Jan; 95 ( Pt 1):23-32. PMID: 2190995.
      Citations: 16     Fields:    Translation:AnimalsCells
    72. Wadsworth P, Shelden E, Rupp G, Rieder CL. Biotin-tubulin incorporates into kinetochore fiber microtubules during early but not late anaphase. J Cell Biol. 1989 Nov; 109(5):2257-65. PMID: 2681228.
      Citations: 12     Fields:    Translation:AnimalsCells
    73. Wadsworth P, Salmon ED. Spindle microtubule dynamics: modulation by metabolic inhibitors. Cell Motil Cytoskeleton. 1988; 11(2):97-105. PMID: 3056623.
      Citations: 5     Fields:    Translation:Cells
    74. Wadsworth P. Microinjected carboxylated beads move predominantly poleward in sea urchin eggs. Cell Motil Cytoskeleton. 1987; 8(4):293-301. PMID: 2891449.
      Citations: 7     Fields:    Translation:AnimalsCells
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