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Patricia Wadsworth PhD

TitleProfessor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address458 Morrill Science Center IV
Amherst, MA 01003
Phone4135454877
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wadsworth P. Novel approaches for imaging the cytoskeleton. Cytoskeleton (Hoboken). 2018 Dec; 75(12):497. PMID: 30681299.
      View in: PubMed
    2. Mann BJ, Wadsworth P. Kinesin-5 Regulation and Function in Mitosis. Trends Cell Biol. 2018 Sep 13. PMID: 30220581.
      View in: PubMed
    3. Mann BJ, Wadsworth P. Distribution of Eg5 and TPX2 in Mitosis: Insight from CRISPR tagged Cells. Cytoskeleton (Hoboken). 2018 Aug 19. PMID: 30123975.
      View in: PubMed
    4. Bickel KG, Mann BJ, Waitzman JS, Poor TA, Rice SE, Wadsworth P. Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5. Cytoskeleton (Hoboken). 2017 Jun 23. PMID: 28646493.
      View in: PubMed
    5. Mann BJ, Balchand SK, Wadsworth P. Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics. Mol Biol Cell. 2017 Jan 01; 28(1):65-75. PMID: 27852894.
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    6. Balchand SK, Mann BJ, Wadsworth P. Using Fluorescence Microscopy to Study Mitosis. Methods Mol Biol. 2016; 1413:3-14. PMID: 27193839.
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    7. Wadsworth P. TPX2. Curr Biol. 2015 Dec 21; 25(24):R1156-8. PMID: 26702647.
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    8. Balchand SK, Mann BJ, Titus J, Ross JL, Wadsworth P. TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule. J Biol Chem. 2015 Jul 10; 290(28):17367-79. PMID: 26018074.
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    9. Collins E, Mann BJ, Wadsworth P. Eg5 restricts anaphase B spindle elongation in mammalian cells. Cytoskeleton (Hoboken). 2014 Feb; 71(2):136-44. PMID: 24285623.
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    10. Wadsworth P, Lee WL. Microtubule motors: doin' it without dynactin. Curr Biol. 2013 Jul 8; 23(13):R563-5. PMID: 23845243.
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    11. Collins ES, Balchand SK, Faraci JL, Wadsworth P, Lee WL. Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase. Mol Biol Cell. 2012 Sep; 23(17):3380-90. PMID: 22809624.
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    12. Gable A, Qiu M, Titus J, Balchand S, Ferenz NP, Ma N, Collins ES, Fagerstrom C, Ross JL, Yang G, Wadsworth P. Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2. Mol Biol Cell. 2012 Apr; 23(7):1254-66. PMID: 22337772.
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    13. Wadsworth P. Using cultured mammalian cells to study mitosis. Cold Spring Harb Protoc. 2012 Feb; 2012(2):205-12. PMID: 22301654.
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    14. Ma N, Titus J, Gable A, Ross JL, Wadsworth P. TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J Cell Biol. 2011 Oct 3; 195(1):87-98. PMID: 21969468.
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    15. Wadsworth P, Lee WL, Murata T, Baskin TI. Variations on theme: spindle assembly in diverse cells. Protoplasma. 2011 Jul; 248(3):439-46. PMID: 20830494.
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    16. Goodson HV, Dzurisin JS, Wadsworth P. Generation of stable cell lines expressing GFP-tubulin and photoactivatable-GFP-tubulin and characterization of clones. Cold Spring Harb Protoc. 2010 Sep; 2010(9):pdb.prot5480. PMID: 20810628.
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    17. Goodson HV, Dzurisin JS, Wadsworth P. Methods for expressing and analyzing GFP-tubulin and GFP-microtubule-associated proteins. Cold Spring Harb Protoc. 2010 Sep; 2010(9):pdb.top85. PMID: 20810643.
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    18. Ferenz NP, Gable A, Wadsworth P. Mitotic functions of kinesin-5. Semin Cell Dev Biol. 2010 May; 21(3):255-9. PMID: 20109572.
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    19. Ma N, Tulu US, Ferenz NP, Fagerstrom C, Wilde A, Wadsworth P. Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Mol Biol Cell. 2010 Mar 15; 21(6):979-88. PMID: 20110350.
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    20. Ferenz NP, Ma N, Lee WL, Wadsworth P. Imaging protein dynamics in live mitotic cells. Methods. 2010 Jun; 51(2):193-6. PMID: 20085816.
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    21. Tulu US, Ferenz NP, Wadsworth P. Photoactivatable green fluorescent protein-tubulin. Methods Cell Biol. 2010; 97:81-90. PMID: 20719266.
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    22. Miquelard-Garnier G, Zimberlin JA, Sikora CB, Wadsworth P, Crosby A. Polymer microlenses for quantifying cell sheet mechanics. Soft Matter. 2010 Jan 01; 6(2):398-403. PMID: 20445765.
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    23. Ferenz NP, Paul R, Fagerstrom C, Mogilner A, Wadsworth P. Dynein antagonizes eg5 by crosslinking and sliding antiparallel microtubules. Curr Biol. 2009 Nov 17; 19(21):1833-8. PMID: 19836236.
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    24. Lee WL, Wadsworth P. New spindle morphogenesis model by Dynein, Nudel, and the spindle matrix. Cell Res. 2009 May; 19(5):529-31. PMID: 19421240.
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    25. Bezanilla M, Wadsworth P. Spindle positioning: actin mediates pushing and pulling. Curr Biol. 2009 Feb 24; 19(4):R168-9. PMID: 19243693.
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    26. Zimberlin JA, Wadsworth P, Crosby AJ. Living microlens arrays. Cell Motil Cytoskeleton. 2008 Sep; 65(9):762-7. PMID: 18615631.
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    27. Murthy K, Wadsworth P. Dual role for microtubules in regulating cortical contractility during cytokinesis. J Cell Sci. 2008 Jul 15; 121(Pt 14):2350-9. PMID: 18559890.
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    28. Ferenz NP, Wadsworth P. Prophase microtubule arrays undergo flux-like behavior in mammalian cells. Mol Biol Cell. 2007 Oct; 18(10):3993-4002. PMID: 17671163.
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    29. Bannigan A, Scheible WR, Lukowitz W, Fagerstrom C, Wadsworth P, Somerville C, Baskin TI. A conserved role for kinesin-5 in plant mitosis. J Cell Sci. 2007 Aug 15; 120(Pt 16):2819-27. PMID: 17652157.
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    30. Yang Z, Tulu US, Wadsworth P, Rieder CL. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr Biol. 2007 Jun 5; 17(11):973-80. PMID: 17509882.
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    31. Wadsworth P. Studying mitosis in cultured Mammalian cells. CSH Protoc. 2007; 2007:pdb.prot4674. PMID: 21357020.
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    32. Daniels R, Rusan NM, Wadsworth P, Hebert DN. SV40 VP2 and VP3 insertion into ER membranes is controlled by the capsid protein VP1: implications for DNA translocation out of the ER. Mol Cell. 2006 Dec 28; 24(6):955-66. PMID: 17189196.
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    33. Daniels R, Rusan NM, Wilbuer AK, Norkin LC, Wadsworth P, Hebert DN. Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes. J Virol. 2006 Jul; 80(13):6575-87. PMID: 16775344.
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    34. Tulu US, Fagerstrom C, Ferenz NP, Wadsworth P. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr Biol. 2006 Mar 07; 16(5):536-41. PMID: 16527751.
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    35. Wadsworth P, Rusan NM, Tulu US, Fagerstrom C. Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells. Nat Methods. 2005 Dec; 2(12):981-7. PMID: 16299485.
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    36. Wadsworth P. Cytokinesis: Rho marks the spot. Curr Biol. 2005 Nov 8; 15(21):R871-4. PMID: 16271857.
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    37. Salaycik KJ, Fagerstrom CJ, Murthy K, Tulu US, Wadsworth P. Quantification of microtubule nucleation, growth and dynamics in wound-edge cells. J Cell Sci. 2005 Sep 15; 118(Pt 18):4113-22. PMID: 16118246.
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    38. Murthy K, Wadsworth P. Myosin-II-dependent localization and dynamics of F-actin during cytokinesis. Curr Biol. 2005 Apr 26; 15(8):724-31. PMID: 15854904.
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    39. Rusan NM, Wadsworth P. Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase. J Cell Biol. 2005 Jan 3; 168(1):21-8. PMID: 15631988.
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    40. Wadsworth P, Khodjakov A. E pluribus unum: towards a universal mechanism for spindle assembly. Trends Cell Biol. 2004 Aug; 14(8):413-9. PMID: 15308207.
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    41. Tulu US, Rusan NM, Wadsworth P. Peripheral, non-centrosome-associated microtubules contribute to spindle formation in centrosome-containing cells. Curr Biol. 2003 Oct 28; 13(21):1894-9. PMID: 14588246.
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    42. Wadsworth P. Cell biology. Persistence pays. Science. 2003 Jun 13; 300(5626):1675-7. PMID: 12805528.
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    43. Rusan NM, Tulu US, Fagerstrom C, Wadsworth P. Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport. J Cell Biol. 2002 Sep 16; 158(6):997-1003. PMID: 12235119.
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    44. Landen JW, Lang R, McMahon SJ, Rusan NM, Yvon AM, Adams AW, Sorcinelli MD, Campbell R, Bonaccorsi P, Ansel JC, Archer DR, Wadsworth P, Armstrong CA, Joshi HC. Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 2002 Jul 15; 62(14):4109-14. PMID: 12124349.
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    45. Yvon AM, Walker JW, Danowski B, Fagerstrom C, Khodjakov A, Wadsworth P. Centrosome reorientation in wound-edge cells is cell type specific. Mol Biol Cell. 2002 Jun; 13(6):1871-80. PMID: 12058055.
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    46. Yvon AM, Gross DJ, Wadsworth P. Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8656-61. PMID: 11438687.
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    47. Rusan NM, Fagerstrom CJ, Yvon AM, Wadsworth P. Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin. Mol Biol Cell. 2001 Apr; 12(4):971-80. PMID: 11294900.
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    48. Yvon AM, Wadsworth P. Region-specific microtubule transport in motile cells. J Cell Biol. 2000 Nov 27; 151(5):1003-12. PMID: 11086002.
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    49. Yvon AM, Wadsworth P, Jordan MA. Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell. 1999 Apr; 10(4):947-59. PMID: 10198049.
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    50. Wadsworth P. Microinjection of mitotic cells. Methods Cell Biol. 1999; 61:219-31. PMID: 9891317.
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    51. Wadsworth P. Regional regulation of microtubule dynamics in polarized, motile cells. Cell Motil Cytoskeleton. 1999; 42(1):48-59. PMID: 9915584.
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    52. McMeekan J, Wadsworth P. Functional assays to identify and characterize regulators of microtubule behavior. Biotechniques. 1998 May; 24(5):870-6. PMID: 9591140.
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    53. Yvon AM, Wadsworth P. Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells. J Cell Sci. 1997 Oct; 110 ( Pt 19):2391-401. PMID: 9410878.
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    54. Wadsworth P, Bottaro DP. Microtubule dynamic turnover is suppressed during polarization and stimulated in hepatocyte growth factor scattered Madin-Darby canine kidney epithelial cells. Cell Motil Cytoskeleton. 1996; 35(3):225-36. PMID: 8913643.
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    55. Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P. Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell. 1995 Sep; 6(9):1215-29. PMID: 8534917.
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    56. Dhamodharan R, Wadsworth P. Modulation of microtubule dynamic instability in vivo by brain microtubule associated proteins. J Cell Sci. 1995 Apr; 108 ( Pt 4):1679-89. PMID: 7615685.
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    57. Hush JM, Wadsworth P, Callaham DA, Hepler PK. Quantification of microtubule dynamics in living plant cells using fluorescence redistribution after photobleaching. J Cell Sci. 1994 Apr; 107 ( Pt 4):775-84. PMID: 8056836.
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    58. Shelden E, Wadsworth P. Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific. J Cell Biol. 1993 Feb; 120(4):935-45. PMID: 8432733.
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    59. Wadsworth P. Mitosis: spindle assembly and chromosome motion. Curr Opin Cell Biol. 1993 Feb; 5(1):123-8. PMID: 8448024.
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    60. Shelden E, Wadsworth P. Microinjection of biotin-tubulin into anaphase cells induces transient elongation of kinetochore microtubules and reversal of chromosome-to-pole motion. J Cell Biol. 1992 Mar; 116(6):1409-20. PMID: 1541637.
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    61. Amin-Hanjani S, Wadsworth P. Inhibition of spindle elongation by taxol. Cell Motil Cytoskeleton. 1991; 20(2):136-44. PMID: 1684311.
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    62. Zhang D, Wadsworth P, Hepler PK. Microtubule dynamics in living dividing plant cells: confocal imaging of microinjected fluorescent brain tubulin. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8820-4. PMID: 11607116.
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    63. Shelden E, Wadsworth P. Interzonal microtubules are dynamic during spindle elongation. J Cell Sci. 1990 Oct; 97 ( Pt 2):273-81. PMID: 2277093.
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    64. Wadsworth P, McGrail M. Interphase microtubule dynamics are cell type-specific. J Cell Sci. 1990 Jan; 95 ( Pt 1):23-32. PMID: 2190995.
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    65. Wadsworth P, Shelden E, Rupp G, Rieder CL. Biotin-tubulin incorporates into kinetochore fiber microtubules during early but not late anaphase. J Cell Biol. 1989 Nov; 109(5):2257-65. PMID: 2681228.
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    66. Wadsworth P, Salmon ED. Spindle microtubule dynamics: modulation by metabolic inhibitors. Cell Motil Cytoskeleton. 1988; 11(2):97-105. PMID: 3056623.
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    67. Wadsworth P. Microinjected carboxylated beads move predominantly poleward in sea urchin eggs. Cell Motil Cytoskeleton. 1987; 8(4):293-301. PMID: 2891449.
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