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Steven J Sandler PhD

InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
AddressMorrill IV North
Amherst, MA 01003
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Duckworth AT, Ducos PL, McMillan SD, Satyshur KA, Blumenthal KH, Deorio HR, Larson JA, Sandler SJ, Grant T, Keck JL. Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli. Nat Commun. 2023 05 11; 14(1):2725. PMID: 37169801.
      Citations:    Fields:    Translation:Cells
    2. Van Alstine S, Sandler SJ. Positive Charges Are Important for the SOS Constitutive Phenotype in recA730 and recA1202 Mutants of Escherichia coli K-12. J Bacteriol. 2022 05 17; 204(5):e0008122. PMID: 35442066.
      Citations:    Fields:    Translation:Cells
    3. Sandler SJ, Leroux M, Windgassen TA, Keck JL. Escherichia coli K-12 has two distinguishable PriA-PriB replication restart pathways. Mol Microbiol. 2021 10; 116(4):1140-1150. PMID: 34423481.
      Citations: 5     Fields:    Translation:Cells
    4. Klimova AN, Sandler SJ. Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12. J Bacteriol. 2020 11 04; 202(23). PMID: 32900829.
      Citations: 3     Fields:    Translation:Cells
    5. Klimova AN, Sandler SJ. An Epistasis Analysis of recA and recN in Escherichia coli K-12. Genetics. 2020 10; 216(2):381-393. PMID: 32816866.
      Citations: 4     Fields:    Translation:Cells
    6. Dubiel K, Henry C, Spenkelink LM, Kozlov AG, Wood EA, Jergic S, Dixon NE, van Oijen AM, Cox MM, Lohman TM, Sandler SJ, Keck JL. Development of a single-stranded DNA-binding protein fluorescent fusion toolbox. Nucleic Acids Res. 2020 06 19; 48(11):6053-6067. PMID: 32374866.
      Citations: 8     Fields:    Translation:Cells
    7. Wolak C, Ma HJ, Soubry N, Sandler SJ, Reyes-Lamothe R, Keck JL. Interaction with single-stranded DNA-binding protein localizes ribonuclease HI to DNA replication forks and facilitates R-loop removal. Mol Microbiol. 2020 09; 114(3):495-509. PMID: 32426857.
      Citations: 7     Fields:    Translation:Cells
    8. Windgassen TA, Leroux M, Sandler SJ, Keck JL. Function of a strand-separation pin element in the PriA DNA replication restart helicase. J Biol Chem. 2019 02 22; 294(8):2801-2814. PMID: 30593500.
      Citations: 15     Fields:    Translation:Cells
    9. Warr AR, Klimova AN, Nwaobasi AN, Sandler SJ. Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes. Mol Microbiol. 2019 02; 111(2):405-422. PMID: 30422330.
      Citations: 5     Fields:    Translation:Cells
    10. Windgassen TA, Leroux M, Satyshur KA, Sandler SJ, Keck JL. Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9075-E9084. PMID: 30201718.
      Citations: 22     Fields:    Translation:Cells
    11. Hayashi JM, Richardson K, Melzer ES, Sandler SJ, Aldridge BB, Siegrist MS, Morita YS. Stress-Induced Reorganization of the Mycobacterial Membrane Domain. mBio. 2018 01 23; 9(1). PMID: 29362232.
      Citations: 17     Fields:    Translation:Cells
    12. Leroux M, Jani N, Sandler SJ. A priA Mutant Expressed in Two Pieces Has Almost Full Activity in Escherichia coli K-12. J Bacteriol. 2017 09 01; 199(17). PMID: 28607160.
      Citations: 4     Fields:    Translation:Cells
    13. Michel B, Sandler SJ. Replication Restart in Bacteria. J Bacteriol. 2017 07 01; 199(13). PMID: 28320884.
      Citations: 39     Fields:    Translation:Cells
    14. Richter LV, Franks AE, Weis RM, Sandler SJ. Significance of a Posttranslational Modification of the PilA Protein of Geobacter sulfurreducens for Surface Attachment, Biofilm Formation, and Growth on Insoluble Extracellular Electron Acceptors. J Bacteriol. 2017 04 15; 199(8). PMID: 28138101.
      Citations: 6     Fields:    Translation:Cells
    15. Wessel SR, Cornilescu CC, Cornilescu G, Metz A, Leroux M, Hu K, Sandler SJ, Markley JL, Keck JL. Structure and Function of the PriC DNA Replication Restart Protein. J Biol Chem. 2016 08 26; 291(35):18384-96. PMID: 27382050.
      Citations: 11     Fields:    Translation:Cells
    16. Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS. Spatially distinct and metabolically active membrane domain in mycobacteria. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5400-5. PMID: 27114527.
      Citations: 35     Fields:    Translation:Cells
    17. Kim T, Chitteni-Pattu S, Cox BL, Wood EA, Sandler SJ, Cox MM. Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination. PLoS Genet. 2015 Jun; 11(6):e1005278. PMID: 26047498.
      Citations: 14     Fields:    Translation:Cells
    18. Sandler SJ. Vive la resistance! Elife. 2014 Jan 01; 3:e02387. PMID: 24596156.
      Citations:    Fields:    Translation:Cells
    19. Bhattacharyya B, George NP, Thurmes TM, Zhou R, Jani N, Wessel SR, Sandler SJ, Ha T, Keck JL. Structural mechanisms of PriA-mediated DNA replication restart. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1373-8. PMID: 24379377.
      Citations: 69     Fields:    Translation:Cells
    20. Massoni SC, Sandler SJ. Specificity in suppression of SOS expression by recA4162 and uvrD303. DNA Repair (Amst). 2013 Dec; 12(12):1072-80. PMID: 24084169.
      Citations: 5     Fields:    Translation:Cells
    21. Wessel SR, Marceau AH, Massoni SC, Zhou R, Ha T, Sandler SJ, Keck JL. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein. J Biol Chem. 2013 Jun 14; 288(24):17569-78. PMID: 23629733.
      Citations: 36     Fields:    Translation:Cells
    22. Pelletier J, Halvorsen K, Ha BY, Paparcone R, Sandler SJ, Woldringh CL, Wong WP, Jun S. Physical manipulation of the Escherichia coli chromosome reveals its soft nature. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):E2649-56. PMID: 22984156.
      Citations: 71     Fields:    Translation:Cells
    23. Massoni SC, Leeson MC, Long JE, Gemme K, Mui A, Sandler SJ. Factors limiting SOS expression in log-phase cells of Escherichia coli. J Bacteriol. 2012 Oct; 194(19):5325-33. PMID: 22843848.
      Citations: 13     Fields:    Translation:Cells
    24. Jang S, Sandler SJ, Harshey RM. Mu insertions are repaired by the double-strand break repair pathway of Escherichia coli. PLoS Genet. 2012; 8(4):e1002642. PMID: 22511883.
      Citations: 13     Fields:    Translation:Cells
    25. Richter LV, Sandler SJ, Weis RM. Two isoforms of Geobacter sulfurreducens PilA have distinct roles in pilus biogenesis, cytochrome localization, extracellular electron transfer, and biofilm formation. J Bacteriol. 2012 May; 194(10):2551-63. PMID: 22408162.
      Citations: 28     Fields:    Translation:Cells
    26. Marceau AH, Bahng S, Massoni SC, George NP, Sandler SJ, Marians KJ, Keck JL. Structure of the SSB-DNA polymerase III interface and its role in DNA replication. EMBO J. 2011 Aug 19; 30(20):4236-47. PMID: 21857649.
      Citations: 84     Fields:    Translation:Cells
    27. Long JE, Massoni SC, Sandler SJ. RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12. J Bacteriol. 2010 May; 192(10):2575-82. PMID: 20304994.
      Citations: 6     Fields:    Translation:Cells
    28. Long JE, Renzette N, Sandler SJ. Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12. Mol Microbiol. 2009 Jul; 73(2):226-39. PMID: 19555451.
      Citations: 7     Fields:    Translation:Cells
    29. Handa N, Amitani I, Gumlaw N, Sandler SJ, Kowalczykowski SC. Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions. J Biol Chem. 2009 Jul 10; 284(28):18664-73. PMID: 19419960.
      Citations: 19     Fields:    Translation:Cells
    30. Long JE, Renzette N, Centore RC, Sandler SJ. Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. PLoS One. 2008; 3(12):e4100. PMID: 19116657.
      Citations: 11     Fields:    Translation:Cells
    31. Centore RC, Leeson MC, Sandler SJ. UvrD303, a hyperhelicase mutant that antagonizes RecA-dependent SOS expression by a mechanism that depends on its C terminus. J Bacteriol. 2009 Mar; 191(5):1429-38. PMID: 19074381.
      Citations: 15     Fields:    Translation:Cells
    32. Gruenig MC, Renzette N, Long E, Chitteni-Pattu S, Inman RB, Cox MM, Sandler SJ. RecA-mediated SOS induction requires an extended filament conformation but no ATP hydrolysis. Mol Microbiol. 2008 Sep; 69(5):1165-79. PMID: 18627467.
      Citations: 29     Fields:    Translation:Cells
    33. Renzette N, Sandler SJ. Requirements for ATP binding and hydrolysis in RecA function in Escherichia coli. Mol Microbiol. 2008 Mar; 67(6):1347-59. PMID: 18298444.
      Citations: 15     Fields:    Translation:Cells
    34. Centore RC, Lestini R, Sandler SJ. XthA (Exonuclease III) regulates loading of RecA onto DNA substrates in log phase Escherichia coli cells. Mol Microbiol. 2008 Jan; 67(1):88-101. PMID: 18034795.
      Citations: 20     Fields:    Translation:Cells
    35. Lopper M, Boonsombat R, Sandler SJ, Keck JL. A hand-off mechanism for primosome assembly in replication restart. Mol Cell. 2007 Jun 22; 26(6):781-93. PMID: 17588514.
      Citations: 45     Fields:    Translation:Cells
    36. Centore RC, Sandler SJ. UvrD limits the number and intensities of RecA-green fluorescent protein structures in Escherichia coli K-12. J Bacteriol. 2007 Apr; 189(7):2915-20. PMID: 17259317.
      Citations: 29     Fields:    Translation:Cells
    37. Renzette N, Gumlaw N, Sandler SJ. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Mol Microbiol. 2007 Jan; 63(1):103-15. PMID: 17163974.
      Citations: 19     Fields:    Translation:Cells
    38. Boonsombat R, Yeh SP, Milne A, Sandler SJ. A novel dnaC mutation that suppresses priB rep mutant phenotypes in Escherichia coli K-12. Mol Microbiol. 2006 May; 60(4):973-83. PMID: 16677308.
      Citations: 10     Fields:    Translation:Cells
    39. Renzette N, Gumlaw N, Nordman JT, Krieger M, Yeh SP, Long E, Centore R, Boonsombat R, Sandler SJ. Localization of RecA in Escherichia coli K-12 using RecA-GFP. Mol Microbiol. 2005 Aug; 57(4):1074-85. PMID: 16091045.
      Citations: 67     Fields:    Translation:Cells
    40. Sandler SJ. Requirements for replication restart proteins during constitutive stable DNA replication in Escherichia coli K-12. Genetics. 2005 Apr; 169(4):1799-806. PMID: 15716497.
      Citations: 28     Fields:    Translation:Cells
    41. Hinds T, Sandler SJ. Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12. BMC Microbiol. 2004 Dec 08; 4:47. PMID: 15588282.
      Citations: 10     Fields:    Translation:Cells
    42. McCool JD, Long E, Petrosino JF, Sandler HA, Rosenberg SM, Sandler SJ. Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy. Mol Microbiol. 2004 Sep; 53(5):1343-57. PMID: 15387814.
      Citations: 103     Fields:    Translation:Cells
    43. McCool JD, Ford CC, Sandler SJ. A dnaT mutant with phenotypes similar to those of a priA2::kan mutant in Escherichia coli K-12. Genetics. 2004 Jun; 167(2):569-78. PMID: 15238512.
      Citations: 21     Fields:    Translation:Cells
    44. McCool JD, Sandler SJ. Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2::kan mutant. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8203-10. PMID: 11459954.
      Citations: 30     Fields:    Translation:Cells
    45. Coppi MV, Leang C, Sandler SJ, Lovley DR. Development of a genetic system for Geobacter sulfurreducens. Appl Environ Microbiol. 2001 Jul; 67(7):3180-7. PMID: 11425739.
      Citations: 140     Fields:    Translation:Cells
    46. Sandler SJ. Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12. Genetics. 2000 Jun; 155(2):487-97. PMID: 10835375.
      Citations: 74     Fields:    Translation:Cells
    47. Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ. The importance of repairing stalled replication forks. Nature. 2000 Mar 02; 404(6773):37-41. PMID: 10716434.
      Citations: 447     Fields:    Translation:Cells
    48. Sandler SJ, Marians KJ. Role of PriA in replication fork reactivation in Escherichia coli. J Bacteriol. 2000 Jan; 182(1):9-13. PMID: 10613856.
      Citations: 85     Fields:    Translation:Cells
    49. Sandler SJ, Marians KJ, Zavitz KH, Coutu J, Parent MA, Clark AJ. dnaC mutations suppress defects in DNA replication- and recombination-associated functions in priB and priC double mutants in Escherichia coli K-12. Mol Microbiol. 1999 Oct; 34(1):91-101. PMID: 10540288.
      Citations: 40     Fields:    Translation:Cells
    50. Liu J, Xu L, Sandler SJ, Marians KJ. Replication fork assembly at recombination intermediates is required for bacterial growth. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3552-5. PMID: 10097074.
      Citations: 50     Fields:    Translation:Cells
    51. Sandler SJ, Hugenholtz P, Schleper C, DeLong EF, Pace NR, Clark AJ. Diversity of radA genes from cultured and uncultured archaea: comparative analysis of putative RadA proteins and their use as a phylogenetic marker. J Bacteriol. 1999 Feb; 181(3):907-15. PMID: 9922255.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    52. Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC. RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange. Genes Dev. 1998 May 01; 12(9):1248-53. PMID: 9573041.
      Citations: 80     Fields:    Translation:Cells
    53. Brendel V, Brocchieri L, Sandler SJ, Clark AJ, Karlin S. Evolutionary comparisons of RecA-like proteins across all major kingdoms of living organisms. J Mol Evol. 1997 May; 44(5):528-41. PMID: 9115177.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    54. Sandler SJ, Satin LH, Samra HS, Clark AJ. recA-like genes from three archaean species with putative protein products similar to Rad51 and Dmc1 proteins of the yeast Saccharomyces cerevisiae. Nucleic Acids Res. 1996 Jun 01; 24(11):2125-32. PMID: 8668545.
      Citations: 47     Fields:    Translation:AnimalsCells
    55. Sandler SJ, Samra HS, Clark AJ. Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC. Genetics. 1996 May; 143(1):5-13. PMID: 8722757.
      Citations: 82     Fields:    Translation:Cells
    56. Sandler SJ. Overlapping functions for recF and priA in cell viability and UV-inducible SOS expression are distinguished by dnaC809 in Escherichia coli K-12. Mol Microbiol. 1996 Feb; 19(4):871-80. PMID: 8820655.
      Citations: 24     Fields:    Translation:Cells
    57. Hegde S, Sandler SJ, Clark AJ, Madiraju MV. recO and recR mutations delay induction of the SOS response in Escherichia coli. Mol Gen Genet. 1995 Jan 20; 246(2):254-8. PMID: 7862097.
      Citations: 25     Fields:    Translation:Cells
    58. Sandler SJ. Studies on the mechanism of reduction of UV-inducible sulAp expression by recF overexpression in Escherichia coli K-12. Mol Gen Genet. 1994 Dec 15; 245(6):741-9. PMID: 7830722.
      Citations: 14     Fields:    Translation:Cells
    59. Sandler SJ, Clark AJ. Mutational analysis of sequences in the recF gene of Escherichia coli K-12 that affect expression. J Bacteriol. 1994 Jul; 176(13):4011-6. PMID: 8021183.
      Citations: 3     Fields:    Translation:Cells
    60. Sandler SJ, Clark AJ. RecOR suppression of recF mutant phenotypes in Escherichia coli K-12. J Bacteriol. 1994 Jun; 176(12):3661-72. PMID: 8206844.
      Citations: 34     Fields:    Translation:Cells
    61. Clark AJ, Sandler SJ. Homologous genetic recombination: the pieces begin to fall into place. Crit Rev Microbiol. 1994; 20(2):125-42. PMID: 8080625.
      Citations: 75     Fields:    Translation:Cells
    62. Clark AJ, Sharma V, Brenowitz S, Chu CC, Sandler S, Satin L, Templin A, Berger I, Cohen A. Genetic and molecular analyses of the C-terminal region of the recE gene from the Rac prophage of Escherichia coli K-12 reveal the recT gene. J Bacteriol. 1993 Dec; 175(23):7673-82. PMID: 8244937.
      Citations: 25     Fields:    Translation:Cells
    63. Sandler SJ, Clark AJ. Use of high and low level overexpression plasmids to test mutant alleles of the recF gene of Escherichia coli K-12 for partial activity. Genetics. 1993 Nov; 135(3):643-54. PMID: 8293970.
      Citations: 18     Fields:    Translation:Cells
    64. Sandler SJ, Chackerian B, Li JT, Clark AJ. Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop. Nucleic Acids Res. 1992 Feb 25; 20(4):839-45. PMID: 1542576.
      Citations: 17     Fields:    Translation:Cells
    65. Sandler SJ, Clark AJ. Factors affecting expression of the recF gene of Escherichia coli K-12. Gene. 1990 Jan 31; 86(1):35-43. PMID: 2155860.
      Citations: 13     Fields:    Translation:Cells
    66. Blanar MA, Sandler SJ, Armengod ME, Ream LW, Clark AJ. Molecular analysis of the recF gene of Escherichia coli. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4622-6. PMID: 6379647.
      Citations: 53     Fields:    Translation:Cells
    67. Clark AJ, Sandler SJ, Willis DK, Chu CC, Blanar MA, Lovett ST. Genes of the RecE and RecF pathways of conjugational recombination in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1984; 49:453-62. PMID: 6397300.
      Citations: 32     Fields:    Translation:Cells
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