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Steven J Sandler PhD

TitleProfessor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
AddressMorrill IV North
Amherst, MA 01003
Phone413-577-4391
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Windgassen TA, Leroux M, Sandler SJ, Keck JL. Function of a strand-separation pin element in the PriA DNA replication restart helicase. J Biol Chem. 2018 Dec 28. PMID: 30593500.
      View in: PubMed
    2. Warr AR, Klimova AN, Nwaobasi AN, Sandler SJ. Protease Deficient-SOS Constitutive Cells have RecN-dependent Cell Division Phenotypes. Mol Microbiol. 2018 Nov 13. PMID: 30422330.
      View in: PubMed
    3. Windgassen TA, Leroux M, Satyshur KA, Sandler SJ, Keck JL. Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase. Proc Natl Acad Sci U S A. 2018 Sep 10. PMID: 30201718.
      View in: PubMed
    4. Hayashi JM, Richardson K, Melzer ES, Sandler SJ, Aldridge BB, Siegrist MS, Morita YS. Stress-Induced Reorganization of the Mycobacterial Membrane Domain. MBio. 2018 Jan 23; 9(1). PMID: 29362232.
      View in: PubMed
    5. Leroux M, Jani N, Sandler SJ. A priA mutant expressed in two pieces has almost full activity in E. coli K-12. J Bacteriol. 2017 Jun 12. PMID: 28607160.
      View in: PubMed
    6. Michel B, Sandler SJ. Replication Restart in Bacteria. J Bacteriol. 2017 Mar 20. PMID: 28320884.
      View in: PubMed
    7. Richter LV, Franks AE, Weis RM, Sandler SJ. Significance of a Post-translational Modification of the PilA Protein of Geobacter sulfurreducens for Surface Attachment, Biofilm Formation and Growth on Insoluble Extracellular Electron Acceptors. J Bacteriol. 2017 Jan 30. PMID: 28138101.
      View in: PubMed
    8. Wessel SR, Cornilescu CC, Cornilescu G, Metz A, Leroux M, Hu K, Sandler SJ, Markley JL, Keck JL. Structure and Function of the PriC DNA Replication Restart Protein. J Biol Chem. 2016 Aug 26; 291(35):18384-96. PMID: 27382050.
      View in: PubMed
    9. Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS. Spatially distinct and metabolically active membrane domain in mycobacteria. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5400-5. PMID: 27114527.
      View in: PubMed
    10. Kim T, Chitteni-Pattu S, Cox BL, Wood EA, Sandler SJ, Cox MM. Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination. PLoS Genet. 2015 Jun; 11(6):e1005278. PMID: 26047498.
      View in: PubMed
    11. Sandler SJ. Vive la resistance! Elife. 2014; 3:e02387. PMID: 24596156.
      View in: PubMed
    12. Bhattacharyya B, George NP, Thurmes TM, Zhou R, Jani N, Wessel SR, Sandler SJ, Ha T, Keck JL. Structural mechanisms of PriA-mediated DNA replication restart. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1373-8. PMID: 24379377.
      View in: PubMed
    13. Massoni SC, Sandler SJ. Specificity in suppression of SOS expression by recA4162 and uvrD303. DNA Repair (Amst). 2013 Dec; 12(12):1072-80. PMID: 24084169.
      View in: PubMed
    14. Wessel SR, Marceau AH, Massoni SC, Zhou R, Ha T, Sandler SJ, Keck JL. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein. J Biol Chem. 2013 Jun 14; 288(24):17569-78. PMID: 23629733.
      View in: PubMed
    15. Pelletier J, Halvorsen K, Ha BY, Paparcone R, Sandler SJ, Woldringh CL, Wong WP, Jun S. Physical manipulation of the Escherichia coli chromosome reveals its soft nature. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):E2649-56. PMID: 22984156.
      View in: PubMed
    16. Massoni SC, Leeson MC, Long JE, Gemme K, Mui A, Sandler SJ. Factors limiting SOS expression in log-phase cells of Escherichia coli. J Bacteriol. 2012 Oct; 194(19):5325-33. PMID: 22843848.
      View in: PubMed
    17. Jang S, Sandler SJ, Harshey RM. Mu insertions are repaired by the double-strand break repair pathway of Escherichia coli. PLoS Genet. 2012; 8(4):e1002642. PMID: 22511883.
      View in: PubMed
    18. Richter LV, Sandler SJ, Weis RM. Two isoforms of Geobacter sulfurreducens PilA have distinct roles in pilus biogenesis, cytochrome localization, extracellular electron transfer, and biofilm formation. J Bacteriol. 2012 May; 194(10):2551-63. PMID: 22408162.
      View in: PubMed
    19. Marceau AH, Bahng S, Massoni SC, George NP, Sandler SJ, Marians KJ, Keck JL. Structure of the SSB-DNA polymerase III interface and its role in DNA replication. EMBO J. 2011 Aug 19; 30(20):4236-47. PMID: 21857649.
      View in: PubMed
    20. Long JE, Massoni SC, Sandler SJ. RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12. J Bacteriol. 2010 May; 192(10):2575-82. PMID: 20304994.
      View in: PubMed
    21. Long JE, Renzette N, Sandler SJ. Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12. Mol Microbiol. 2009 Jul; 73(2):226-39. PMID: 19555451.
      View in: PubMed
    22. Handa N, Amitani I, Gumlaw N, Sandler SJ, Kowalczykowski SC. Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions. J Biol Chem. 2009 Jul 10; 284(28):18664-73. PMID: 19419960.
      View in: PubMed
    23. Long JE, Renzette N, Centore RC, Sandler SJ. Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. PLoS One. 2008; 3(12):e4100. PMID: 19116657.
      View in: PubMed
    24. Centore RC, Leeson MC, Sandler SJ. UvrD303, a hyperhelicase mutant that antagonizes RecA-dependent SOS expression by a mechanism that depends on its C terminus. J Bacteriol. 2009 Mar; 191(5):1429-38. PMID: 19074381.
      View in: PubMed
    25. Gruenig MC, Renzette N, Long E, Chitteni-Pattu S, Inman RB, Cox MM, Sandler SJ. RecA-mediated SOS induction requires an extended filament conformation but no ATP hydrolysis. Mol Microbiol. 2008 Sep; 69(5):1165-79. PMID: 18627467.
      View in: PubMed
    26. Renzette N, Sandler SJ. Requirements for ATP binding and hydrolysis in RecA function in Escherichia coli. Mol Microbiol. 2008 Mar; 67(6):1347-59. PMID: 18298444.
      View in: PubMed
    27. Centore RC, Lestini R, Sandler SJ. XthA (Exonuclease III) regulates loading of RecA onto DNA substrates in log phase Escherichia coli cells. Mol Microbiol. 2008 Jan; 67(1):88-101. PMID: 18034795.
      View in: PubMed
    28. Lopper M, Boonsombat R, Sandler SJ, Keck JL. A hand-off mechanism for primosome assembly in replication restart. Mol Cell. 2007 Jun 22; 26(6):781-93. PMID: 17588514.
      View in: PubMed
    29. Centore RC, Sandler SJ. UvrD limits the number and intensities of RecA-green fluorescent protein structures in Escherichia coli K-12. J Bacteriol. 2007 Apr; 189(7):2915-20. PMID: 17259317.
      View in: PubMed
    30. Renzette N, Gumlaw N, Sandler SJ. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Mol Microbiol. 2007 Jan; 63(1):103-15. PMID: 17163974.
      View in: PubMed
    31. Boonsombat R, Yeh SP, Milne A, Sandler SJ. A novel dnaC mutation that suppresses priB rep mutant phenotypes in Escherichia coli K-12. Mol Microbiol. 2006 May; 60(4):973-83. PMID: 16677308.
      View in: PubMed
    32. Renzette N, Gumlaw N, Nordman JT, Krieger M, Yeh SP, Long E, Centore R, Boonsombat R, Sandler SJ. Localization of RecA in Escherichia coli K-12 using RecA-GFP. Mol Microbiol. 2005 Aug; 57(4):1074-85. PMID: 16091045.
      View in: PubMed
    33. Sandler SJ. Requirements for replication restart proteins during constitutive stable DNA replication in Escherichia coli K-12. Genetics. 2005 Apr; 169(4):1799-806. PMID: 15716497.
      View in: PubMed
    34. Hinds T, Sandler SJ. Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12. BMC Microbiol. 2004; 4:47. PMID: 15588282.
      View in: PubMed
    35. McCool JD, Long E, Petrosino JF, Sandler HA, Rosenberg SM, Sandler SJ. Measurement of SOS expression in individual Escherichia coli K-12 cells using fluorescence microscopy. Mol Microbiol. 2004 Sep; 53(5):1343-57. PMID: 15387814.
      View in: PubMed
    36. McCool JD, Ford CC, Sandler SJ. A dnaT mutant with phenotypes similar to those of a priA2::kan mutant in Escherichia coli K-12. Genetics. 2004 Jun; 167(2):569-78. PMID: 15238512.
      View in: PubMed
    37. Lloyd JR, Leang C, Hodges Myerson AL, Coppi MV, Cuifo S, Methe B, Sandler SJ, Lovley DR. Biochemical and genetic characterization of PpcA, a periplasmic c-type cytochrome in Geobacter sulfurreducens. Biochem J. 2003 Jan 1; 369(Pt 1):153-61. PMID: 12356333.
      View in: PubMed
    38. Sandler SJ, McCool JD, Do TT, Johansen RU. PriA mutations that affect PriA-PriC function during replication restart. Mol Microbiol. 2001 Aug; 41(3):697-704. PMID: 11532137.
      View in: PubMed
    39. McCool JD, Sandler SJ. Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2::kan mutant. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8203-10. PMID: 11459954.
      View in: PubMed
    40. Coppi MV, Leang C, Sandler SJ, Lovley DR. Development of a genetic system for Geobacter sulfurreducens. Appl Environ Microbiol. 2001 Jul; 67(7):3180-7. PMID: 11425739.
      View in: PubMed
    41. Sandler SJ. Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12. Genetics. 2000 Jun; 155(2):487-97. PMID: 10835375.
      View in: PubMed
    42. Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ. The importance of repairing stalled replication forks. Nature. 2000 Mar 2; 404(6773):37-41. PMID: 10716434.
      View in: PubMed
    43. Sandler SJ, Marians KJ. Role of PriA in replication fork reactivation in Escherichia coli. J Bacteriol. 2000 Jan; 182(1):9-13. PMID: 10613856.
      View in: PubMed
    44. Sandler SJ, Marians KJ, Zavitz KH, Coutu J, Parent MA, Clark AJ. dnaC mutations suppress defects in DNA replication- and recombination-associated functions in priB and priC double mutants in Escherichia coli K-12. Mol Microbiol. 1999 Oct; 34(1):91-101. PMID: 10540288.
      View in: PubMed
    45. Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 1999 Aug; 42(Suppl 1):A1-A330. PMID: 27770183.
      View in: PubMed
    46. Liu J, Xu L, Sandler SJ, Marians KJ. Replication fork assembly at recombination intermediates is required for bacterial growth. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3552-5. PMID: 10097074.
      View in: PubMed
    47. Sandler SJ, Hugenholtz P, Schleper C, DeLong EF, Pace NR, Clark AJ. Diversity of radA genes from cultured and uncultured archaea: comparative analysis of putative RadA proteins and their use as a phylogenetic marker. J Bacteriol. 1999 Feb; 181(3):907-15. PMID: 9922255.
      View in: PubMed
    48. Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC. RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange. Genes Dev. 1998 May 1; 12(9):1248-53. PMID: 9573041.
      View in: PubMed
    49. Brendel V, Brocchieri L, Sandler SJ, Clark AJ, Karlin S. Evolutionary comparisons of RecA-like proteins across all major kingdoms of living organisms. J Mol Evol. 1997 May; 44(5):528-41. PMID: 9115177.
      View in: PubMed
    50. Sandler SJ, Satin LH, Samra HS, Clark AJ. recA-like genes from three archaean species with putative protein products similar to Rad51 and Dmc1 proteins of the yeast Saccharomyces cerevisiae. Nucleic Acids Res. 1996 Jun 1; 24(11):2125-32. PMID: 8668545.
      View in: PubMed
    51. Sandler SJ, Samra HS, Clark AJ. Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC. Genetics. 1996 May; 143(1):5-13. PMID: 8722757.
      View in: PubMed
    52. Sandler SJ. Overlapping functions for recF and priA in cell viability and UV-inducible SOS expression are distinguished by dnaC809 in Escherichia coli K-12. Mol Microbiol. 1996 Feb; 19(4):871-80. PMID: 8820655.
      View in: PubMed
    53. Hegde S, Sandler SJ, Clark AJ, Madiraju MV. recO and recR mutations delay induction of the SOS response in Escherichia coli. Mol Gen Genet. 1995 Jan 20; 246(2):254-8. PMID: 7862097.
      View in: PubMed
    54. Sandler SJ. Studies on the mechanism of reduction of UV-inducible sulAp expression by recF overexpression in Escherichia coli K-12. Mol Gen Genet. 1994 Dec 15; 245(6):741-9. PMID: 7830722.
      View in: PubMed
    55. Sandler SJ, Clark AJ. Mutational analysis of sequences in the recF gene of Escherichia coli K-12 that affect expression. J Bacteriol. 1994 Jul; 176(13):4011-6. PMID: 8021183.
      View in: PubMed
    56. Sandler SJ, Clark AJ. RecOR suppression of recF mutant phenotypes in Escherichia coli K-12. J Bacteriol. 1994 Jun; 176(12):3661-72. PMID: 8206844.
      View in: PubMed
    57. Clark AJ, Sandler SJ. Homologous genetic recombination: the pieces begin to fall into place. Crit Rev Microbiol. 1994; 20(2):125-42. PMID: 8080625.
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    58. Clark AJ, Sharma V, Brenowitz S, Chu CC, Sandler S, Satin L, Templin A, Berger I, Cohen A. Genetic and molecular analyses of the C-terminal region of the recE gene from the Rac prophage of Escherichia coli K-12 reveal the recT gene. J Bacteriol. 1993 Dec; 175(23):7673-82. PMID: 8244937.
      View in: PubMed
    59. Sandler SJ, Clark AJ. Use of high and low level overexpression plasmids to test mutant alleles of the recF gene of Escherichia coli K-12 for partial activity. Genetics. 1993 Nov; 135(3):643-54. PMID: 8293970.
      View in: PubMed
    60. Sandler SJ, Chackerian B, Li JT, Clark AJ. Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop. Nucleic Acids Res. 1992 Feb 25; 20(4):839-45. PMID: 1542576.
      View in: PubMed
    61. Sandler SJ, Clark AJ. Factors affecting expression of the recF gene of Escherichia coli K-12. Gene. 1990 Jan 31; 86(1):35-43. PMID: 2155860.
      View in: PubMed
    62. Blanar MA, Sandler SJ, Armengod ME, Ream LW, Clark AJ. Molecular analysis of the recF gene of Escherichia coli. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4622-6. PMID: 6379647.
      View in: PubMed
    63. Clark AJ, Sandler SJ, Willis DK, Chu CC, Blanar MA, Lovett ST. Genes of the RecE and RecF pathways of conjugational recombination in Escherichia coli. Cold Spring Harb Symp Quant Biol. 1984; 49:453-62. PMID: 6397300.
      View in: PubMed
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