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Igor Kaltashov PhD

TitleProfessor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address267 Goessman Laboratory
Amherst, MA 01003
Phone413-545-1460
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nat Methods. 2019 07; 16(7):595-602. PMID: 31249422.
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    2. Dinges SS, Hohm A, Vandergrift LA, Nowak J, Habbel P, Kaltashov IA, Cheng LL. Cancer metabolomic markers in urine: evidence, techniques and recommendations. Nat Rev Urol. 2019 May 15. PMID: 31092915.
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    3. Ren C, Bobst CE, Kaltashov IA. EXPLOITING HIS-TAGS FOR ABSOLUTE QUANTITATION OF EXOGENOUS RECOMBINANT PROTEINS IN BIOLOGICAL MATRICES: RUTHENIUM AS A PROTEIN TRACER. Anal Chem. 2019 May 14. PMID: 31083917.
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    4. Minsky BB, Abzalimov RR, Niu C, Zhao Y, Kirsch Z, Dubin PL, Savinov SN, Kaltashov IA. Mass Spectrometry Reveals a Multifaceted Role of Glycosaminoglycan Chains in Factor Xa Inactivation by Antithrombin. Biochemistry. 2018 Aug 14; 57(32):4880-4890. PMID: 29999301.
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    5. Kaltashov IA. Mass spectrometry-based methods to study macromolecular higher order structure and interactions. Methods. 2018 Jul 15; 144:1-2. PMID: 30017108.
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    6. Liu J, Tu ZC, Liu GX, Niu CD, Yao HL, Wang H, Sha XM, Shao YH, Kaltashov IA. Ultrasonic Pretreatment Combined with Dry-State Glycation Reduced the Immunoglobulin E/Immunoglobulin G-Binding Ability of a-Lactalbumin Revealed by High-Resolution Mass Spectrometry. J Agric Food Chem. 2018 Jun 06; 66(22):5691-5698. PMID: 29758985.
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    7. Kaltashov IA, Pawlowski JW, Yang W, Muneeruddin K, Yao H, Bobst CE, Lipatnikov AN. LC/MS at the whole protein level: Studies of biomolecular structure and interactions using native LC/MS and cross-path reactive chromatography (XP-RC) MS. Methods. 2018 Apr 25. PMID: 29702225.
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    8. Yang W, Tu Z, Wang H, Zhang L, Kaltashov IA, Zhao Y, Niu C, Yao H, Ye W. The mechanism of reduced IgG/IgE-binding of ß-lactoglobulin by pulsed electric field pretreatment combined with glycation revealed by ECD/FTICR-MS. Food Funct. 2018 Jan 24; 9(1):417-425. PMID: 29220053.
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    9. Wang G, Bondarenko PV, Kaltashov IA. Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry. Analyst. 2018 Feb 07; 143(3):670-677. PMID: 29303166.
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    10. Pawlowski JW, Bajardi-Taccioli A, Houde D, Feschenko M, Carlage T, Kaltashov IA. Influence of glycan modification on IgG1 biochemical and biophysical properties. J Pharm Biomed Anal. 2018 Mar 20; 151:133-144. PMID: 29324282.
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    11. Pawlowski JW, Carrick I, Kaltashov IA. Integration of On-Column Chemical Reactions in Protein Characterization by Liquid Chromatography/Mass Spectrometry: Cross-Path Reactive Chromatography. Anal Chem. 2018 Jan 16; 90(2):1348-1355. PMID: 29240412.
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    12. Huang HT, Bobst CE, Iwig JS, Chivers PT, Kaltashov IA, Maroney MJ. Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N terminus, alters helix dynamics, and reduces DNA affinity. J Biol Chem. 2018 Jan 05; 293(1):324-332. PMID: 29150441.
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    13. Yang W, Tu Z, Wang H, Zhang L, Xu S, Niu C, Yao H, Kaltashov IA. Mechanism of Reduction in IgG and IgE Binding of ß-Lactoglobulin Induced by Ultrasound Pretreatment Combined with Dry-State Glycation: A Study Using Conventional Spectrometry and High-Resolution Mass Spectrometry. J Agric Food Chem. 2017 Sep 13; 65(36):8018-8027. PMID: 28800703.
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    14. Xu S, Kaltashov IA. Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein. Mol Pharm. 2017 Aug 07; 14(8):2843-2851. PMID: 28712302.
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    15. Minsky BB, Dubin PL, Kaltashov IA. Electrostatic Forces as Dominant Interactions Between Proteins and Polyanions: an ESI MS Study of Fibroblast Growth Factor Binding to Heparin Oligomers. J Am Soc Mass Spectrom. 2017 Feb 16. PMID: 28211013.
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    16. Muneeruddin K, Bobst CE, Frenkel R, Houde D, Turyan I, Sosic Z, Kaltashov IA. Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS. Analyst. 2017 Jan 16; 142(2):336-344. PMID: 27965993.
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    17. Beckmann N, Kaltashov IA, Windhorst AD. Editorial: In vivo Imaging in Pharmacological Research. Front Pharmacol. 2016; 7:511. PMID: 28096795.
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    18. Xu S, Kaltashov IA. Evaluation of Gallium as a Tracer of Exogenous Hemoglobin-Haptoglobin Complexes for Targeted Drug Delivery Applications. J Am Soc Mass Spectrom. 2016 Dec; 27(12):2025-2032. PMID: 27619921.
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    19. Fatunmbi O, Abzalimov RR, Savinov SN, Gershenson A, Kaltashov IA. Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry. Biochemistry. 2016 Mar 29; 55(12):1918-28. PMID: 26937685.
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    20. Zhao Y, Abzalimov RR, Kaltashov IA. Interactions of Intact Unfractionated Heparin with Its Client Proteins Can Be Probed Directly Using Native Electrospray Ionization Mass Spectrometry. Anal Chem. 2016 Feb 2; 88(3):1711-8. PMID: 26707758.
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    21. Pawlowski JW, Kellicker N, Bobst CE, Kaltashov IA. Assessing the iron delivery efficacy of transferrin in clinical samples by native electrospray ionization mass spectrometry. Analyst. 2016 Feb 7; 141(3):853-61. PMID: 26646585.
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    22. Muneeruddin K, Nazzaro M, Kaltashov IA. Characterization of intact protein conjugates and biopharmaceuticals using ion-exchange chromatography with online detection by native electrospray ionization mass spectrometry and top-down tandem mass spectrometry. Anal Chem. 2015 Oct 6; 87(19):10138-45. PMID: 26360183.
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    23. Zhao H, Wang S, Nguyen SN, Elci SG, Kaltashov IA. Evaluation of Nonferrous Metals as Potential In Vivo Tracers of Transferrin-Based Therapeutics. J Am Soc Mass Spectrom. 2016 Feb; 27(2):211-9. PMID: 26392277.
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    24. Wang S, Kaltashov IA. Identification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid. J Am Soc Mass Spectrom. 2015 May; 26(5):800-7. PMID: 25716754.
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    25. Wang S, Bobst CE, Kaltashov IA. A new liquid chromatography-mass spectrometry-based method to quantitate exogenous recombinant transferrin in cerebrospinal fluid: a potential approach for pharmacokinetic studies of transferrin-based therapeutics in the central nervous systems. Eur J Mass Spectrom (Chichester). 2015; 21(3):369-76. PMID: 26307718.
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    26. Muneeruddin K, Thomas JJ, Salinas PA, Kaltashov IA. Characterization of small protein aggregates and oligomers using size exclusion chromatography with online detection by native electrospray ionization mass spectrometry. Anal Chem. 2014 Nov 4; 86(21):10692-9. PMID: 25310183.
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    27. Wang G, Kaltashov IA. Approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometry. Anal Chem. 2014 Aug 5; 86(15):7293-8. PMID: 24988145.
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    28. Bobst CE, Kaltashov IA. Enhancing the quality of H/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation. Anal Chem. 2014 Jun 3; 86(11):5225-31. PMID: 24820935.
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    29. Wang G, Abzalimov RR, Bobst CE, Kaltashov IA. Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20087-92. PMID: 24277803.
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    30. Luck AN, Bobst CE, Kaltashov IA, Mason AB. Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia? Biochemistry. 2013 Nov 19; 52(46):8333-41. PMID: 24152109.
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    31. Minsky BB, Nguyen TV, Peyton SR, Kaltashov IA, Dubin PL. Heparin decamer bridges a growth factor and an oligolysine by different charge-driven interactions. Biomacromolecules. 2013 Nov 11; 14(11):4091-8. PMID: 24107074.
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    32. Abzalimov RR, Bobst CE, Kaltashov IA. A new approach to measuring protein backbone protection with high spatial resolution using H/D exchange and electron capture dissociation. Anal Chem. 2013 Oct 1; 85(19):9173-80. PMID: 23978257.
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    33. Wang S, Kaltashov IA. An 18O-labeling assisted LC/MS method for assignment of aspartyl/isoaspartyl products from Asn deamidation and Asp isomerization in proteins. Anal Chem. 2013 Jul 2; 85(13):6446-52. PMID: 23713887.
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    34. Beckmann N, Kaltashov IA. Delivery of biopharmaceuticals: advanced analytical and biophysical methods. Adv Drug Deliv Rev. 2013 Jul; 65(8):1001. PMID: 23688785.
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    35. Kaltashov IA, Bobst CE, Nguyen SN, Wang S. Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers. Adv Drug Deliv Rev. 2013 Jul; 65(8):1020-30. PMID: 23624418.
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    36. Nguyen SN, Bobst CE, Kaltashov IA. Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate. Mol Pharm. 2013 May 6; 10(5):1998-2007. PMID: 23534953.
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    37. Kaltashov IA, Bobst CE, Abzalimov RR. Mass spectrometry-based methods to study protein architecture and dynamics. Protein Sci. 2013 May; 22(5):530-44. PMID: 23436701.
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    38. Minsky BB, Atmuri A, Kaltashov IA, Dubin PL. Counterion condensation on heparin oligomers. Biomacromolecules. 2013 Apr 8; 14(4):1113-21. PMID: 23458385.
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    39. Abzalimov RR, Bobst CE, Salinas PA, Savickas P, Thomas JJ, Kaltashov IA. Studies of pH-dependent self-association of a recombinant form of arylsulfatase A with electrospray ionization mass spectrometry and size-exclusion chromatography. Anal Chem. 2013 Feb 5; 85(3):1591-6. PMID: 23252501.
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    40. Bobst CE, Wang S, Shen WC, Kaltashov IA. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13544-8. PMID: 22869744.
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    41. Steere AN, Bobst CE, Zhang D, Pettit SC, Kaltashov IA, Huang N, Mason AB. Biochemical and structural characterization of recombinant human serum transferrin from rice (Oryza sativa L.). J Inorg Biochem. 2012 Nov; 116:37-44. PMID: 23010327.
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    42. Wang S, Kaltashov IA. A new strategy of using O18-labeled iodoacetic acid for mass spectrometry-based protein quantitation. J Am Soc Mass Spectrom. 2012 Jul; 23(7):1293-7. PMID: 22562395.
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    43. Sjoelund V, Kaltashov IA. Modification of the zonal elution method for detection of transient protein-protein interactions involving ligand exchange. Anal Chem. 2012 May 15; 84(10):4608-12. PMID: 22500549.
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    44. Wang G, Johnson AJ, Kaltashov IA. Evaluation of electrospray ionization mass spectrometry as a tool for characterization of small soluble protein aggregates. Anal Chem. 2012 Feb 7; 84(3):1718-24. PMID: 22240037.
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    45. Abzalimov RR, Frimpong AK, Kaltashov IA. Detection and characterization of large-scale protein conformational transitions in solution using charge-state distribution analysis in ESI-MS. Methods Mol Biol. 2012; 896:365-73. PMID: 22821537.
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    46. Bobst CE, Kaltashov IA. Localizing flexible regions in proteins using hydrogen-deuterium exchange mass spectrometry. Methods Mol Biol. 2012; 896:375-85. PMID: 22821538.
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    47. Bobst CE, Kaltashov IA. Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products. Curr Pharm Biotechnol. 2011 Oct; 12(10):1517-29. PMID: 21542797.
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    48. Wang S, Bobst CE, Kaltashov IA. Pitfalls in protein quantitation using acid-catalyzed O18 labeling: hydrolysis-driven deamidation. Anal Chem. 2011 Sep 15; 83(18):7227-32. PMID: 21819098.
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    49. Kaltashov IA, Bobst CE, Zhang M, Leverence R, Gumerov DR. Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry. Biochim Biophys Acta. 2012 Mar; 1820(3):417-26. PMID: 21726602.
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    50. Kaltashov IA, Bobst CE, Abzalimov RR, Wang G, Baykal B, Wang S. Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics. Biotechnol Adv. 2012 Jan-Feb; 30(1):210-22. PMID: 21619926.
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    51. Wang G, Abzalimov RR, Kaltashov IA. Direct monitoring of heat-stressed biopolymers with temperature-controlled electrospray ionization mass spectrometry. Anal Chem. 2011 Apr 15; 83(8):2870-6. PMID: 21417416.
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    52. Bobst CE, Thomas JJ, Salinas PA, Savickas P, Kaltashov IA. Impact of oxidation on protein therapeutics: conformational dynamics of intact and oxidized acid-ß-glucocerebrosidase at near-physiological pH. Protein Sci. 2010 Dec; 19(12):2366-78. PMID: 20945356.
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    53. Abzalimov RR, Kaltashov IA. Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction. Anal Chem. 2010 Sep 15; 82(18):7523-6. PMID: 20731408.
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    54. Leverence R, Mason AB, Kaltashov IA. Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry. Proc Natl Acad Sci U S A. 2010 May 4; 107(18):8123-8. PMID: 20404192.
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    55. Frimpong AK, Abzalimov RR, Uversky VN, Kaltashov IA. Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein. Proteins. 2010 Feb 15; 78(3):714-22. PMID: 19847913.
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    56. Abzalimov RR, Kaltashov IA. Controlling hydrogen scrambling in multiply charged protein ions during collisional activation: implications for top-down hydrogen/deuterium exchange MS utilizing collisional activation in the gas phase. Anal Chem. 2010 Feb 1; 82(3):942-50. PMID: 20055445.
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    57. Steere AN, Roberts SE, Byrne SL, Dennis Chasteen N, Bobst CE, Kaltashov IA, Smith VC, MacGillivray RT, Mason AB. Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin. Protein Expr Purif. 2010 Jul; 72(1):32-41. PMID: 20064616.
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    58. Kaltashov IA, Bobst CE, Abzalimov RR, Berkowitz SA, Houde D. Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry. J Am Soc Mass Spectrom. 2010 Mar; 21(3):323-37. PMID: 19963397.
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    59. Kaltashov IA, Bobst CE, Abzalimov RR. H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach? Anal Chem. 2009 Oct 1; 81(19):7892-9. PMID: 19694441.
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    60. Abzalimov RR, Kaplan DA, Easterling ML, Kaltashov IA. Protein conformations can be probed in top-down HDX MS experiments utilizing electron transfer dissociation of protein ions without hydrogen scrambling. J Am Soc Mass Spectrom. 2009 Aug; 20(8):1514-7. PMID: 19467606.
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    61. Bobst CE, Zhang M, Kaltashov IA. Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry. J Mol Biol. 2009 May 22; 388(5):954-67. PMID: 19324057.
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    62. Mason AB, Halbrooks PJ, James NG, Byrne SL, Grady JK, Chasteen ND, Bobst CE, Kaltashov IA, Smith VC, MacGillivray RT, Everse SJ. Structural and functional consequences of the substitution of glycine 65 with arginine in the N-lobe of human transferrin. Biochemistry. 2009 Mar 10; 48(9):1945-53. PMID: 19219998.
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    63. Bobst CE, Abzalimov RR, Houde D, Kloczewiak M, Mhatre R, Berkowitz SA, Kaltashov IA. Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches. Anal Chem. 2008 Oct 1; 80(19):7473-81. PMID: 18729476.
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    64. Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Biochemistry. 2008 Sep 16; 47(37):9847-55. PMID: 18712936.
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    65. Kaltashov IA, Abzalimov RR. Do ionic charges in ESI MS provide useful information on macromolecular structure? J Am Soc Mass Spectrom. 2008 Sep; 19(9):1239-46. PMID: 18602274.
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    66. Smit J, Kaltashov IA, Kaltoshov IA, Cotter RJ, Vinogradov E, Perry MB, Haider H, Qureshi N. Structure of a novel lipid A obtained from the lipopolysaccharide of Caulobacter crescentus. Innate Immun. 2008 Feb; 14(1):25-37. PMID: 18387917.
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    67. Sjoelund V, Kaltashov IA. Transporter-to-trap conversion: a disulfide bond formation in cellular retinoic acid binding protein I mutant triggered by retinoic acid binding irreversibly locks the ligand inside the protein. Biochemistry. 2007 Nov 20; 46(46):13382-90. PMID: 17958379.
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    68. Wang F, Lothrop AP, James NG, Griffiths TA, Lambert LA, Leverence R, Kaltashov IA, Andrews NC, MacGillivray RT, Mason AB. A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. Biochem J. 2007 Aug 15; 406(1):85-95. PMID: 17511619.
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    69. Abzalimov RR, Dubin PL, Kaltashov IA. Glycosaminoglycans as naturally occurring combinatorial libraries: developing a mass spectrometry-based strategy for characterization of anti-thrombin interaction with low molecular weight heparin and heparin oligomers. Anal Chem. 2007 Aug 15; 79(16):6055-63. PMID: 17658885.
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    70. Frimpong AK, Abzalimov RR, Eyles SJ, Kaltashov IA. Gas-phase interference-free analysis of protein ion charge-state distributions: detection of small-scale conformational transitions accompanying pepsin inactivation. Anal Chem. 2007 Jun 1; 79(11):4154-61. PMID: 17477507.
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    71. Griffith WP, Kaltashov IA. Protein conformational heterogeneity as a binding catalyst: ESI-MS study of hemoglobin H formation. Biochemistry. 2007 Feb 20; 46(7):2020-6. PMID: 17253776.
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    72. Kaltashov IA, Zhang M, Eyles SJ, Abzalimov RR. Investigation of structure, dynamics and function of metalloproteins with electrospray ionization mass spectrometry. Anal Bioanal Chem. 2006 Oct; 386(3):472-81. PMID: 16932945.
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    73. Abzalimov RR, Kaltashov IA. Extraction of local hydrogen exchange data from HDX CAD MS measurements by deconvolution of isotopic distributions of fragment ions. J Am Soc Mass Spectrom. 2006 Nov; 17(11):1543-51. PMID: 16934998.
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    74. Zhang M, Kaltashov IA. Mapping of protein disulfide bonds using negative ion fragmentation with a broadband precursor selection. Anal Chem. 2006 Jul 15; 78(14):4820-9. PMID: 16841900.
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    75. Byrne SL, Leverence R, Klein JS, Giannetti AM, Smith VC, MacGillivray RT, Kaltashov IA, Mason AB. Effect of glycosylation on the function of a soluble, recombinant form of the transferrin receptor. Biochemistry. 2006 May 30; 45(21):6663-73. PMID: 16716077.
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    76. Hoerner JK, Xiao H, Kaltashov IA. Structural and dynamic characteristics of a partially folded state of ubiquitin revealed by hydrogen exchange mass spectrometry. Biochemistry. 2005 Aug 23; 44(33):11286-94. PMID: 16101313.
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    77. Kaltashov IA, Mohimen A. Estimates of protein surface areas in solution by electrospray ionization mass spectrometry. Anal Chem. 2005 Aug 15; 77(16):5370-9. PMID: 16097782.
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    78. Xiao H, Kaltashov IA. Transient structural disorder as a facilitator of protein-ligand binding: native H/D exchange-mass spectrometry study of cellular retinoic acid binding protein I. J Am Soc Mass Spectrom. 2005 Jun; 16(6):869-79. PMID: 15907702.
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    79. Xiao H, Hoerner JK, Eyles SJ, Dobo A, Voigtman E, Mel'cuk AI, Kaltashov IA. Mapping protein energy landscapes with amide hydrogen exchange and mass spectrometry: I. A generalized model for a two-state protein and comparison with experiment. Protein Sci. 2005 Feb; 14(2):543-57. PMID: 15659380.
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    80. Zhang M, Gumerov DR, Kaltashov IA, Mason AB. Indirect detection of protein-metal binding: interaction of serum transferrin with In3+ and Bi3+. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1658-64. PMID: 15519234.
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    81. Eyles SJ, Kaltashov IA. Methods to study protein dynamics and folding by mass spectrometry. Methods. 2004 Sep; 34(1):88-99. PMID: 15283918.
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    82. Hoerner JK, Xiao H, Dobo A, Kaltashov IA. Is there hydrogen scrambling in the gas phase? Energetic and structural determinants of proton mobility within protein ions. J Am Chem Soc. 2004 Jun 23; 126(24):7709-17. PMID: 15198619.
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    83. Griffith WP, Kaltashov IA. Highly asymmetric interactions between globin chains during hemoglobin assembly revealed by electrospray ionization mass spectrometry. Biochemistry. 2003 Aug 26; 42(33):10024-33. PMID: 12924951.
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    84. Mohimen A, Dobo A, Hoerner JK, Kaltashov IA. A chemometric approach to detection and characterization of multiple protein conformers in solution using electrospray ionization mass spectrometry. Anal Chem. 2003 Aug 15; 75(16):4139-47. PMID: 14632127.
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    85. Gumerov DR, Mason AB, Kaltashov IA. Interlobe communication in human serum transferrin: metal binding and conformational dynamics investigated by electrospray ionization mass spectrometry. Biochemistry. 2003 May 13; 42(18):5421-8. PMID: 12731884.
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    86. Xiao H, Kaltashov IA, Eyles SJ. Indirect assessment of small hydrophobic ligand binding to a model protein using a combination of ESI MS and HDX/ESI MS. J Am Soc Mass Spectrom. 2003 May; 14(5):506-15. PMID: 12745220.
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    87. Mason AB, He QY, Halbrooks PJ, Everse SJ, Gumerov DR, Kaltashov IA, Smith VC, Hewitt J, MacGillivray RT. Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin. Biochemistry. 2002 Jul 30; 41(30):9448-54. PMID: 12135367.
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    88. Kaltashov IA, Eyles SJ. Crossing the phase boundary to study protein dynamics and function: combination of amide hydrogen exchange in solution and ion fragmentation in the gas phase. J Mass Spectrom. 2002 Jun; 37(6):557-65. PMID: 12112737.
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    89. Kaltashov IA, Eyles SJ. Studies of biomolecular conformations and conformational dynamics by mass spectrometry. Mass Spectrom Rev. 2002 Jan-Feb; 21(1):37-71. PMID: 12210613.
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    90. Dobo A, Kaltashov IA. Detection of multiple protein conformational ensembles in solution via deconvolution of charge-state distributions in ESI MS. Anal Chem. 2001 Oct 15; 73(20):4763-73. PMID: 11681449.
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    91. Mason AB, He QY, Adams TE, Gumerov DR, Kaltashov IA, Nguyen V, MacGillivray RT. Expression, purification, and characterization of recombinant nonglycosylated human serum transferrin containing a C-terminal hexahistidine tag. Protein Expr Purif. 2001 Oct; 23(1):142-50. PMID: 11570856.
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    92. Gumerov DR, Kaltashov IA. Dynamics of iron release from transferrin N-lobe studied by electrospray ionization mass spectrometry. Anal Chem. 2001 Jun 1; 73(11):2565-70. PMID: 11403301.
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    93. Kaltashov IA, Li A, Szilágyi Z, Vékey K, Fenselau C. Secondary structure of peptide ions in the gas phase evaluated by MIKE spectrometry. Relevance to native conformations. Methods Mol Biol. 2000; 146:133-46. PMID: 10948500.
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    94. Eyles SJ, Dresch T, Gierasch LM, Kaltashov IA. Unfolding dynamics of a beta-sheet protein studied by mass spectrometry. J Mass Spectrom. 1999 Dec; 34(12):1289-95. PMID: 10587623.
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    95. Li A, Fenselau C, Kaltashov IA. Stability of secondary structural elements in a solvent-free environment. II: the beta-pleated sheets. Proteins. 1998; Suppl 2:22-7. PMID: 9849907.
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    96. Dotson GD, Kaltashov IA, Cotter RJ, Raetz CR. Expression cloning of a Pseudomonas gene encoding a hydroxydecanoyl-acyl carrier protein-dependent UDP-GlcNAc acyltransferase. J Bacteriol. 1998 Jan; 180(2):330-7. PMID: 9440522.
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    97. Odegaard TJ, Kaltashov IA, Cotter RJ, Steeghs L, van der Ley P, Khan S, Maskell DJ, Raetz CR. Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase. J Biol Chem. 1997 Aug 8; 272(32):19688-96. PMID: 9242624.
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    98. Kaltashov IA, Doroshenko V, Cotter RJ, Takayama K, Qureshi N. Confirmation of the structure of lipid A derived from the lipopolysaccharide of Rhodobacter sphaeroides by a combination of MALDI, LSIMS, and tandem mass spectrometry. Anal Chem. 1997 Jul 1; 69(13):2317-22. PMID: 9212704.
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    99. White KA, Kaltashov IA, Cotter RJ, Raetz CR. A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae. J Biol Chem. 1997 Jun 27; 272(26):16555-63. PMID: 9195966.
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    100. Kaltashov IA, Doroshenko VM, Cotter RJ. Gas phase hydrogen/deuterium exchange reactions of peptide ions in a quadrupole ion trap mass spectrometer. Proteins. 1997 May; 28(1):53-8. PMID: 9144790.
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    101. Qureshi N, Kaltashov I, Walker K, Doroshenko V, Cotter RJ, Takayama K, Sievert TR, Rice PA, Lin JS, Golenbock DT. Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem. 1997 Apr 18; 272(16):10594-600. PMID: 9099706.
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    102. Kaltashov IA, Fenselau C. Stability of secondary structural elements in a solvent-free environment: the alpha helix. Proteins. 1997 Feb; 27(2):165-70. PMID: 9061780.
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    103. Kaltashov IA, Yu X, Fenselau C. Simple interface for microbore LC and electrospray ionization mass spectrometry and analysis of melphalan-alkylation sites in metallothionein. J Pharm Biomed Anal. 1995 Mar; 13(3):279-84. PMID: 7619888.
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    104. Dickinson RG, King AR, Kelly MA, Kaltashov IA, Fenselau C. Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate--identification using ESI-MS. J Pharm Biomed Anal. 1994 Sep; 12(9):1075-8. PMID: 7803554.
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