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Neil Forbes PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Engineering
Address101 Goessman Lab
Amherst, MA 01003
Phone413 577 0132
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shave MK, Xu Z, Raman V, Kalasin S, Tuominen MT, Forbes NS, Santore MM. Escherichia coli Swimming back Toward Stiffer Polyetheylene Glycol Coatings, Increasing Contact in Flow. ACS Appl Mater Interfaces. 2021 Apr 21; 13(15):17196-17206. PMID: 33821607.
      View in: PubMed
    2. Sharma A, Raman V, Lee J, Forbes NS. Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-a and IL-8 secretion. Biotechnol Bioeng. 2020 May 12. PMID: 32396232.
      View in: PubMed
    3. Panteli JT, Van Dessel N, Forbes NS. Detection of Tumors with Fluorophore-Releasing Bacteria. Int J Cancer. 2019 May 16. PMID: 31093970.
      View in: PubMed
    4. Raman V, Van Dessel N, O'Connor OM, Forbes NS. The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella. J Immunother Cancer. 2019 Feb 12; 7(1):44. PMID: 30755273.
      View in: PubMed
    5. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 Aug 06; 6(1):78. PMID: 30081947.
      View in: PubMed
    6. Ganz DE, Sexton-Stallone B, Brackett EL, Forbes NS. Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs. J Theor Biol. 2018 Feb 07; 438:21-33. PMID: 29066114.
      View in: PubMed
    7. Panteli JT, Forbes NS. Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses. Biotechnol Bioeng. 2016 Nov; 113(11):2474-84. PMID: 27159665.
      View in: PubMed
    8. Brackett EL, Swofford CA, Forbes NS. Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue. Methods Mol Biol. 2016; 1409:35-48. PMID: 26846800.
      View in: PubMed
    9. Thornlow DN, Brackett EL, Gigas JM, Van Dessel N, Forbes NS. Persistent enhancement of bacterial motility increases tumor penetration. Biotechnol Bioeng. 2015 Nov; 112(11):2397-405. PMID: 25976712.
      View in: PubMed
    10. Panteli JT, Forkus BA, Van Dessel N, Forbes NS. Genetically modified bacteria as a tool to detect microscopic solid tumor masses with triggered release of a recombinant biomarker. Integr Biol (Camb). 2015 Apr; 7(4):423-34. PMID: 25737274.
      View in: PubMed
    11. Swofford CA, Van Dessel N, Forbes NS. Quorum-sensing Salmonella selectively trigger protein expression within tumors. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3457-62. PMID: 25737556.
      View in: PubMed
    12. Van Dessel N, Swofford CA, Forbes NS. Potent and tumor specific: arming bacteria with therapeutic proteins. Ther Deliv. 2015 Mar; 6(3):385-99. PMID: 25853312.
      View in: PubMed
    13. Zhang M, Forbes NS. Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating. J Control Release. 2015 Feb 10; 199:180-9. PMID: 25523033.
      View in: PubMed
    14. St Jean AT, Swofford CA, Panteli JT, Brentzel ZJ, Forbes NS. Bacterial delivery of Staphylococcus aureus a-hemolysin causes regression and necrosis in murine tumors. Mol Ther. 2014 Jul; 22(7):1266-74. PMID: 24590046.
      View in: PubMed
    15. Swofford CA, St Jean AT, Panteli JT, Brentzel ZJ, Forbes NS. Identification of Staphylococcus aureus a-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells. Biotechnol Bioeng. 2014 Jun; 111(6):1233-45. PMID: 24415346.
      View in: PubMed
    16. Kasinskas RW, Venkatasubramanian R, Forbes NS. Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol (Camb). 2014 Apr; 6(4):399-410. PMID: 24503640.
      View in: PubMed
    17. Zhang M, Swofford CA, Forbes NS. Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice. Int J Cancer. 2014 Aug 1; 135(3):647-57. PMID: 24374783.
      View in: PubMed
    18. Toley BJ, Tropeano Lovatt ZG, Harrington JL, Forbes NS. Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil. Integr Biol (Camb). 2013 Sep; 5(9):1184-96. PMID: 23860772.
      View in: PubMed
    19. Dai Y, Toley BJ, Swofford CA, Forbes NS. Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue. Biotechnol Bioeng. 2013 Jun; 110(6):1769-81. PMID: 23280328.
      View in: PubMed
    20. Toley BJ, Park J, Kim BJ, Venkatasubramanian R, Maharbiz MM, Forbes NS. Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro. Biotechnol Prog. 2012 Mar-Apr; 28(2):515-25. PMID: 22228537.
      View in: PubMed
    21. Toley BJ, Forbes NS. Motility is critical for effective distribution and accumulation of bacteria in tumor tissue. Integr Biol (Camb). 2012 Feb; 4(2):165-76. PMID: 22193245.
      View in: PubMed
    22. Toley BJ, Ganz DE, Walsh CL, Forbes NS. Microfluidic device for recreating a tumor microenvironment in vitro. J Vis Exp. 2011 Nov 20; (57). PMID: 22126742.
      View in: PubMed
    23. Forbes NS. Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer. 2010 Nov; 10(11):785-94. PMID: 20944664.
      View in: PubMed
    24. Hunnewell MG, Forbes NS. Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog. 2010 May-Jun; 26(3):789-96. PMID: 20014107.
      View in: PubMed
    25. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72. PMID: 20383126.
      View in: PubMed
    26. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8. PMID: 19206385.
      View in: PubMed
    27. Walsh CL, Babin BM, Kasinskas RW, Foster JA, McGarry MJ, Forbes NS. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip. 2009 Feb 21; 9(4):545-54. PMID: 19190790.
      View in: PubMed
    28. Kim BJ, Forbes NS. Single-cell analysis demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumor cylindroids. Biotechnol Bioeng. 2008 Nov 1; 101(4):797-810. PMID: 18814293.
      View in: PubMed
    29. St Jean AT, Zhang M, Forbes NS. Bacterial therapies: completing the cancer treatment toolbox. Curr Opin Biotechnol. 2008 Oct; 19(5):511-7. PMID: 18760353.
      View in: PubMed
    30. Venkatasubramanian R, Henson MA, Forbes NS. Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies. J Theor Biol. 2008 Jul 7; 253(1):98-117. PMID: 18402980.
      View in: PubMed
    31. Kim BJ, Forbes NS. Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. Biotechnol Bioeng. 2007 Apr 15; 96(6):1167-82. PMID: 17009333.
      View in: PubMed
    32. Kasinskas RW, Forbes NS. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 2007 Apr 1; 67(7):3201-9. PMID: 17409428.
      View in: PubMed
    33. Forbes NS. Profile of a bacterial tumor killer. Nat Biotechnol. 2006 Dec; 24(12):1484-5. PMID: 17160044.
      View in: PubMed
    34. Kasinskas RW, Forbes NS. Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Biotechnol Bioeng. 2006 Jul 5; 94(4):710-21. PMID: 16470601.
      View in: PubMed
    35. Forbes NS, Meadows AL, Clark DS, Blanch HW. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metab Eng. 2006 Nov; 8(6):639-52. PMID: 16904360.
      View in: PubMed
    36. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3165-9. PMID: 16572498.
      View in: PubMed
    37. Venkatasubramanian R, Henson MA, Forbes NS. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 2006 Sep 21; 242(2):440-53. PMID: 16650438.
      View in: PubMed
    38. Hong R, Han G, Fernández JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 1; 128(4):1078-9. PMID: 16433515.
      View in: PubMed
    39. Forbes NS, Munn LL, Fukumura D, Jain RK. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 2003 Sep 1; 63(17):5188-93. PMID: 14500342.
      View in: PubMed
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