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Neil Forbes PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Engineering
Address101 Goessman Lab
Amherst, MA 01003
Phone413 577 0132
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Raman V, Hall CL, Wetherby VE, Whitney SA, Van Dessel N, Forbes NS. Controlling intracellular protein delivery, tumor colonization and tissue distribution using flhDC in clinically relevant ?sseJ Salmonella. Mol Ther. 2025 Feb 05; 33(2):649-669. PMID: 39741404.
      Citations:    
    2. Manole S, Nguyen DH, Min JJ, Zhou S, Forbes N. Setting "cold" tumors on fire: Cancer therapy with live tumor-targeting bacteria. Med. 2025 Jan 10; 6(1):100549. PMID: 39689707.
      Citations:    
    3. Howell LM, Manole S, Reitter AR, Forbes NS. Controlled production of lipopolysaccharides increases immune activation in Salmonella treatments of cancer. Microb Biotechnol. 2024 05; 17(5):e14461. PMID: 38758181.
      Citations:    
    4. Khanduja S, Bloom SMK, Raman V, Deshpande CP, Hall CL, Forbes NS. Intracellular delivery of oncolytic viruses with engineered Salmonella causes viral replication and cell death. iScience. 2024 Jun 21; 27(6):109813. PMID: 38799578.
      Citations:    
    5. Raman V, Deshpande CP, Khanduja S, Howell LM, Van Dessel N, Forbes NS. Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies. Cell Host Microbe. 2023 10 11; 31(10):1574-1592. PMID: 37827116.
      Citations:    Fields:    Translation:Humans
    6. Raman V, Howell LM, Bloom SMK, Hall CL, Wetherby VE, Minter LM, Kulkarni AA, Forbes NS. Intracellular Salmonella delivery of an exogenous immunization antigen refocuses CD8 T cells against cancer cells, eliminates pancreatic tumors and forms antitumor immunity. Front Immunol. 2023; 14:1228532. PMID: 37868996.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Bloom SMK, O'Hare N, Forbes NS. Bacterial delivery of therapeutic proteins to the nuclei of cancer cells. Biotechnol Bioeng. 2023 05; 120(5):1437-1448. PMID: 36710503.
      Citations:    Fields:    Translation:Cells
    8. Sharma A, Raman V, Lee J, Forbes NS. Microbial Imbalance Induces Inflammation by Promoting Salmonella Penetration through the Mucosal Barrier. ACS Infect Dis. 2022 05 13; 8(5):969-981. PMID: 35404574.
      Citations:    Fields:    Translation:HumansCells
    9. Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Janabi HA, Demiral S, Perrie Y, Essand M, Weglarz A, Cruz LJ, Lewis CE, Muthana M. Targeting circulating monocytes with CCL2-loaded liposomes armed with an oncolytic adenovirus. Nanomedicine. 2022 02; 40:102506. PMID: 34875352.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Raman V, Van Dessel N, Hall CL, Wetherby VE, Whitney SA, Kolewe EL, Bloom SMK, Sharma A, Hardy JA, Bollen M, Van Eynde A, Forbes NS. Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases. Nat Commun. 2021 10 21; 12(1):6116. PMID: 34675204.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Howell LM, Forbes NS. Bacteria-based immune therapies for cancer treatment. Semin Cancer Biol. 2022 11; 86(Pt 2):1163-1178. PMID: 34547442.
      Citations: 4     Fields:    Translation:HumansCells
    12. Shave MK, Xu Z, Raman V, Kalasin S, Tuominen MT, Forbes NS, Santore MM. Escherichia coli Swimming back Toward Stiffer Polyetheylene Glycol Coatings, Increasing Contact in Flow. ACS Appl Mater Interfaces. 2021 Apr 21; 13(15):17196-17206. PMID: 33821607.
      Citations: 2     Fields:    Translation:Cells
    13. Sharma A, Raman V, Lee J, Forbes NS. Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-a and IL-8 secretion. Biotechnol Bioeng. 2020 08; 117(8):2540-2555. PMID: 32396232.
      Citations: 3     Fields:    Translation:HumansCells
    14. Sharma A, Kwak JG, Kolewe KW, Schiffman JD, Forbes NS, Lee J. In Vitro Reconstitution of an Intestinal Mucus Layer Shows That Cations and pH Control the Pore Structure That Regulates Its Permeability and Barrier Function. ACS Appl Bio Mater. 2020 May 18; 3(5):2897-2909. PMID: 34322659.
      Citations: 4     Fields:    
    15. Panteli JT, Van Dessel N, Forbes NS. Detection of tumors with fluoromarker-releasing bacteria. Int J Cancer. 2020 01 01; 146(1):137-149. PMID: 31093970.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Raman V, Van Dessel N, O'Connor OM, Forbes NS. The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella. J Immunother Cancer. 2019 02 12; 7(1):44. PMID: 30755273.
      Citations: 10     Fields:    Translation:HumansCells
    17. Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018 08 06; 6(1):78. PMID: 30081947.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    18. Ganz DE, Sexton-Stallone B, Brackett EL, Forbes NS. Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs. J Theor Biol. 2018 02 07; 438:21-33. PMID: 29066114.
      Citations: 1     Fields:    
    19. Panteli JT, Forbes NS. Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses. Biotechnol Bioeng. 2016 11; 113(11):2474-84. PMID: 27159665.
      Citations: 14     Fields:    Translation:HumansCells
    20. Brackett EL, Swofford CA, Forbes NS. Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue. Methods Mol Biol. 2016; 1409:35-48. PMID: 26846800.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Thornlow DN, Brackett EL, Gigas JM, Van Dessel N, Forbes NS. Persistent enhancement of bacterial motility increases tumor penetration. Biotechnol Bioeng. 2015 Nov; 112(11):2397-405. PMID: 25976712.
      Citations: 11     Fields:    Translation:HumansCells
    22. Panteli JT, Forkus BA, Van Dessel N, Forbes NS. Genetically modified bacteria as a tool to detect microscopic solid tumor masses with triggered release of a recombinant biomarker. Integr Biol (Camb). 2015 Apr; 7(4):423-34. PMID: 25737274.
      Citations: 12     Fields:    Translation:HumansCells
    23. Swofford CA, Van Dessel N, Forbes NS. Quorum-sensing Salmonella selectively trigger protein expression within tumors. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3457-62. PMID: 25737556.
      Citations: 39     Fields:    Translation:AnimalsCells
    24. Van Dessel N, Swofford CA, Forbes NS. Potent and tumor specific: arming bacteria with therapeutic proteins. Ther Deliv. 2015 Mar; 6(3):385-99. PMID: 25853312.
      Citations: 17     Fields:    Translation:HumansCells
    25. Zhang M, Forbes NS. Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating. J Control Release. 2015 Feb 10; 199:180-9. PMID: 25523033.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. St Jean AT, Swofford CA, Panteli JT, Brentzel ZJ, Forbes NS. Bacterial delivery of Staphylococcus aureus a-hemolysin causes regression and necrosis in murine tumors. Mol Ther. 2014 Jul; 22(7):1266-1274. PMID: 24590046.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Swofford CA, St Jean AT, Panteli JT, Brentzel ZJ, Forbes NS. Identification of Staphylococcus aureus a-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells. Biotechnol Bioeng. 2014 Jun; 111(6):1233-45. PMID: 24415346.
      Citations: 20     Fields:    Translation:HumansCells
    28. Kasinskas RW, Venkatasubramanian R, Forbes NS. Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol (Camb). 2014 Apr; 6(4):399-410. PMID: 24503640.
      Citations: 18     Fields:    Translation:HumansCells
    29. Zhang M, Swofford CA, Forbes NS. Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice. Int J Cancer. 2014 Aug 01; 135(3):647-57. PMID: 24374783.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Toley BJ, Tropeano Lovatt ZG, Harrington JL, Forbes NS. Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil. Integr Biol (Camb). 2013 Sep; 5(9):1184-96. PMID: 23860772.
      Citations: 15     Fields:    Translation:HumansCells
    31. Dai Y, Toley BJ, Swofford CA, Forbes NS. Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue. Biotechnol Bioeng. 2013 Jun; 110(6):1769-81. PMID: 23280328.
      Citations: 14     Fields:    Translation:HumansCells
    32. Toley BJ, Park J, Kim BJ, Venkatasubramanian R, Maharbiz MM, Forbes NS. Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro. Biotechnol Prog. 2012 Mar-Apr; 28(2):515-25. PMID: 22228537.
      Citations: 4     Fields:    Translation:HumansCells
    33. Toley BJ, Forbes NS. Motility is critical for effective distribution and accumulation of bacteria in tumor tissue. Integr Biol (Camb). 2012 Feb; 4(2):165-76. PMID: 22193245.
      Citations: 48     Fields:    Translation:HumansCells
    34. Toley BJ, Ganz DE, Walsh CL, Forbes NS. Microfluidic device for recreating a tumor microenvironment in vitro. J Vis Exp. 2011 Nov 20; (57). PMID: 22126742.
      Citations: 5     Fields:    Translation:HumansCells
    35. Forbes NS. Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer. 2010 Nov; 10(11):785-94. PMID: 20944664.
      Citations: 273     Fields:    Translation:HumansAnimalsCells
    36. Hunnewell MG, Forbes NS. Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog. 2010 May-Jun; 26(3):789-96. PMID: 20014107.
      Citations: 5     Fields:    Translation:AnimalsCells
    37. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72. PMID: 20383126.
      Citations: 140     Fields:    Translation:HumansCells
    38. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8. PMID: 19206385.
      Citations: 98     Fields:    Translation:AnimalsCells
    39. Walsh CL, Babin BM, Kasinskas RW, Foster JA, McGarry MJ, Forbes NS. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip. 2009 Feb 21; 9(4):545-54. PMID: 19190790.
      Citations: 46     Fields:    Translation:HumansCells
    40. Kim BJ, Forbes NS. Single-cell analysis demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumor cylindroids. Biotechnol Bioeng. 2008 Nov 01; 101(4):797-810. PMID: 18814293.
      Citations: 16     Fields:    Translation:AnimalsCells
    41. St Jean AT, Zhang M, Forbes NS. Bacterial therapies: completing the cancer treatment toolbox. Curr Opin Biotechnol. 2008 Oct; 19(5):511-7. PMID: 18760353.
      Citations: 25     Fields:    Translation:Humans
    42. Venkatasubramanian R, Henson MA, Forbes NS. Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies. J Theor Biol. 2008 Jul 07; 253(1):98-117. PMID: 18402980.
      Citations: 17     Fields:    Translation:HumansCells
    43. Kim BJ, Forbes NS. Flux analysis shows that hypoxia-inducible-factor-1-alpha minimally affects intracellular metabolism in tumor spheroids. Biotechnol Bioeng. 2007 Apr 15; 96(6):1167-82. PMID: 17009333.
      Citations: 16     Fields:    Translation:AnimalsCells
    44. Kasinskas RW, Forbes NS. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res. 2007 Apr 01; 67(7):3201-9. PMID: 17409428.
      Citations: 93     Fields:    Translation:HumansCells
    45. Forbes NS. Profile of a bacterial tumor killer. Nat Biotechnol. 2006 Dec; 24(12):1484-5. PMID: 17160044.
      Citations: 13     Fields:    Translation:HumansCells
    46. Kasinskas RW, Forbes NS. Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Biotechnol Bioeng. 2006 Jul 05; 94(4):710-21. PMID: 16470601.
      Citations: 77     Fields:    Translation:HumansCells
    47. Forbes NS, Meadows AL, Clark DS, Blanch HW. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metab Eng. 2006 Nov; 8(6):639-52. PMID: 16904360.
      Citations: 34     Fields:    Translation:HumansCells
    48. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 05; 45(19):3165-9. PMID: 16572498.
      Citations: 52     Fields:    Translation:Cells
    49. Venkatasubramanian R, Henson MA, Forbes NS. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 2006 Sep 21; 242(2):440-53. PMID: 16650438.
      Citations: 29     Fields:    Translation:HumansCells
    50. Hong R, Han G, Fern?ndez JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 01; 128(4):1078-9. PMID: 16433515.
      Citations: 131     Fields:    
    51. Forbes NS, Munn LL, Fukumura D, Jain RK. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 2003 Sep 01; 63(17):5188-93. PMID: 14500342.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
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