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Jeanne A Hardy BS, PhD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address1021G Lederle Graduate Research Tower
Amherst, MA 01003
Phone4135453486
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Raman V, Van Dessel N, Hall CL, Wetherby VE, Whitney SA, Kolewe EL, Bloom SMK, Sharma A, Hardy JA, Bollen M, Van Eynde A, Forbes NS. Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases. Nat Commun. 2021 Oct 21; 12(1):6116. PMID: 34675204.
      View in: PubMed
    2. Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. ACS Chem Biol. 2021 Sep 23. PMID: 34553588.
      View in: PubMed
    3. Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. 2021 Sep 02. PMID: 34472839.
      View in: PubMed
    4. Anson F, Thayumanavan S, Hardy JA. Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes. JACS Au. 2021 Aug 23; 1(8):1240-1256. PMID: 34467362.
      View in: PubMed
    5. Anson F, Liu B, Kanjilal P, Wu P, Hardy JA, Thayumanavan S. Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP. Biomacromolecules. 2021 Mar 08; 22(3):1261-1272. PMID: 33591168.
      View in: PubMed
    6. Anson F, Kanjilal P, Thayumanavan S, Hardy JA. Tracking exogenous intracellular casp-3 using split GFP. Protein Sci. 2020 Nov 09. PMID: 33165988.
      View in: PubMed
    7. Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodríguez R. A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. J Biol Chem. 2020 Jan 09. PMID: 31919100.
      View in: PubMed
    8. Pham B, Eron SJ, Hill ME, Li X, Fahie MA, Hardy JA, Chen M. A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates. Biophys J. 2019 Aug 02. PMID: 31427065.
      View in: PubMed
    9. Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP-Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. 2019 May 16. PMID: 31095371.
      View in: PubMed
    10. Hill ME, Yildiz M, Hardy JA. Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease. Biochemistry. 2018 Nov 26. PMID: 30472839.
      View in: PubMed
    11. MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. J Biol Chem. 2018 Nov 12. PMID: 30420425.
      View in: PubMed
    12. Hardy JA. Fighting Kinase Drug Resistance with Caspase Activators. Cell Chem Biol. 2018 Aug 16; 25(8):927-928. PMID: 30118670.
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    13. Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. ACS Chem Biol. 2018 Aug 06. PMID: 30080377.
      View in: PubMed
    14. Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA. Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8. ACS Chem Biol. 2018 May 18; 13(5):1279-1290. PMID: 29364645.
      View in: PubMed
    15. Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD?:?core domain interactions require a properly formed active site. Biochem J. 2018 Mar 29; 475(6):1177-1196. PMID: 29500231.
      View in: PubMed
    16. Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Sci Rep. 2018 Mar 13; 8(1):4428. PMID: 29535332.
      View in: PubMed
    17. Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core. Cell Death Differ. 2018 Jun; 25(6):1025-1039. PMID: 29352269.
      View in: PubMed
    18. Homyak CC, Fernandez A, Touve MA, Zhao B, Anson F, Hardy JA, Vachet RW, Gianneschi NC, Ross JL, Thayumanavan S. Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules. Biomacromolecules. 2018 Jan 08; 19(1):132-140. PMID: 29141403.
      View in: PubMed
    19. Raghupathi K, Eron SJ, Anson F, Hardy JA, Thayumanavan S. Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery. Mol Pharm. 2017 Dec 04; 14(12):4515-4524. PMID: 29053277.
      View in: PubMed
    20. Serrano BP, Szydlo HS, Alfandari D, Hardy JA. Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. J Biol Chem. 2017 Dec 29; 292(52):21352-21365. PMID: 29066624.
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    21. Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E7977-E7986. PMID: 28864531.
      View in: PubMed
    22. Dagbay KB, Hill ME, Barrett E, Hardy JA. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. 2017 08 29; 56(34):4568-4577. PMID: 28726391.
      View in: PubMed
    23. Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion Upon Substrate Binding. J Biol Chem. 2017 Feb 02. PMID: 28154009.
      View in: PubMed
    24. Eron SJ, Raghupathi K, Hardy JA. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure. 2016 Nov 22. PMID: 27889207.
      View in: PubMed
    25. Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 Jun 17; 11(6):1603-12. PMID: 27032039.
      View in: PubMed
    26. Ventura J, Eron SJ, González-Toro DC, Raghupathi K, Wang F, Hardy JA, Thayumanavan S. Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein. Biomacromolecules. 2015 Oct 12; 16(10):3161-71. PMID: 26331939.
      View in: PubMed
    27. Kim CS, Mout R, Zhao Y, Yeh YC, Tang R, Jeong Y, Duncan B, Hardy JA, Rotello VM. Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules. Bioconjug Chem. 2015 May 20; 26(5):950-4. PMID: 25894332.
      View in: PubMed
    28. Dagbay K, Eron SJ, Serrano BP, Velázquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA. A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods Enzymol. 2014; 544:215-49. PMID: 24974292.
      View in: PubMed
    29. Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA. Allosteric inhibition of the NS2B-NS3 protease from dengue virus. ACS Chem Biol. 2013 Dec 20; 8(12):2744-52. PMID: 24164286.
      View in: PubMed
    30. Tang R, Kim CS, Solfiell DJ, Rana S, Mout R, Velázquez-Delgado EM, Chompoosor A, Jeong Y, Yan B, Zhu ZJ, Kim C, Hardy JA, Rotello VM. Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. ACS Nano. 2013 Aug 27; 7(8):6667-73. PMID: 23815280.
      View in: PubMed
    31. Wu P, Nicholls SB, Hardy JA. A tunable, modular approach to fluorescent protease-activated reporters. Biophys J. 2013 Apr 2; 104(7):1605-14. PMID: 23561537.
      View in: PubMed
    32. Nicholls SB, Hardy JA. Structural basis of fluorescence quenching in caspase activatable-GFP. Protein Sci. 2013 Mar; 22(3):247-57. PMID: 23139158.
      View in: PubMed
    33. Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS. Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics. Biol Chem. 2012 Sep; 393(9):933-41. PMID: 22944693.
      View in: PubMed
    34. Velázquez-Delgado EM, Hardy JA. Zinc-mediated allosteric inhibition of caspase-6. J Biol Chem. 2012 Oct 19; 287(43):36000-11. PMID: 22891250.
      View in: PubMed
    35. Jagodzinski F, Hardy J, Streinu I. Using rigidity analysis to probe mutation-induced structural changes in proteins. J Bioinform Comput Biol. 2012 Jun; 10(3):1242010. PMID: 22809386.
      View in: PubMed
    36. Huber KL, Hardy JA. Mechanism of zinc-mediated inhibition of caspase-9. Protein Sci. 2012 Jul; 21(7):1056-65. PMID: 22573662.
      View in: PubMed
    37. Velázquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure. 2012 Apr 4; 20(4):742-51. PMID: 22483120.
      View in: PubMed
    38. López GE, Colón-Díaz I, Cruz A, Ghosh S, Nicholls SB, Viswanathan U, Hardy JA, Auerbach SM. Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles. J Phys Chem A. 2012 Feb 2; 116(4):1283-8. PMID: 22188565.
      View in: PubMed
    39. Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 2012; 98(5):451-65. PMID: 23203690.
      View in: PubMed
    40. Witkowski WA, Hardy JA. A designed redox-controlled caspase. Protein Sci. 2011 Aug; 20(8):1421-31. PMID: 21674661.
      View in: PubMed
    41. Nicholls SB, Chu J, Abbruzzese G, Tremblay KD, Hardy JA. Mechanism of a genetically encoded dark-to-bright reporter for caspase activity. J Biol Chem. 2011 Jul 15; 286(28):24977-86. PMID: 21558267.
      View in: PubMed
    42. Vaidya S, Hardy JA. Caspase-6 latent state stability relies on helical propensity. Biochemistry. 2011 Apr 26; 50(16):3282-7. PMID: 21381717.
      View in: PubMed
    43. Vaidya S, Velázquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol. 2011 Feb 11; 406(1):75-91. PMID: 21111746.
      View in: PubMed
    44. Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem. 2009 Sep 18; 284(38):26063-9. PMID: 19581639.
      View in: PubMed
    45. Witkowski WA, Hardy JA. L2' loop is critical for caspase-7 active site formation. Protein Sci. 2009 Jul; 18(7):1459-68. PMID: 19530232.
      View in: PubMed
    46. Huber KL, Olson KD, Hardy JA. Robust production of a peptide library using methodological synchronization. Protein Expr Purif. 2009 Oct; 67(2):139-47. PMID: 19457455.
      View in: PubMed
    47. Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Curr Opin Struct Biol. 2004 Dec; 14(6):706-15. PMID: 15582395.
      View in: PubMed
    48. Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12461-6. PMID: 15314233.
      View in: PubMed
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