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James J Chambers PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address602 Lederle Graduate Research Tower
Amherst, MA 01003
Phone413-545-3864
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Afonso O, Castellani CM, Cheeseman LP, Ferreira JG, Orr B, Ferreira LT, Chambers JJ, Morais-de-Sá E, Maresca TJ, Maiato H. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife. 2019 Aug 19; 8. PMID: 31424385.
      View in: PubMed
    2. Melzer ES, Sein CE, Chambers JJ, Sloan Siegrist M. DivIVA concentrates mycobacterial cell envelope assembly for initiation and stabilization of polar growth. Cytoskeleton (Hoboken). 2018 Aug 30. PMID: 30160378.
      View in: PubMed
    3. McCarron ST, Chambers JJ. Modular chemical probes for visualizing and tracking endogenous ion channels. Neuropharmacology. 2015 Nov; 98:41-7. PMID: 25866020.
      View in: PubMed
    4. Combs-Bachmann RE, Johnson JN, Vytla D, Hussey AM, Kilfoil ML, Chambers JJ. Ligand-directed delivery of fluorophores to track native calcium-permeable AMPA receptors in neuronal cultures. J Neurochem. 2015 May; 133(3):320-9. PMID: 25640258.
      View in: PubMed
    5. Hussey AM, Chambers JJ. Methods to locate and track ion channels and receptors expressed in live neurons. ACS Chem Neurosci. 2015 Jan 21; 6(1):189-98. PMID: 25307447.
      View in: PubMed
    6. Lin WC, Davenport CM, Mourot A, Vytla D, Smith CM, Medeiros KA, Chambers JJ, Kramer RH. Engineering a light-regulated GABAA receptor for optical control of neural inhibition. ACS Chem Biol. 2014 Jul 18; 9(7):1414-9. PMID: 24819442.
      View in: PubMed
    7. Gann AW, Amoroso JW, Einck VJ, Rice WP, Chambers JJ, Schnarr NA. A photoinduced, benzyne click reaction. Org Lett. 2014 Apr 4; 16(7):2003-5. PMID: 24625300.
      View in: PubMed
    8. Chambers JJ. Delivery of chemical cargo to endogenous proteins on live cells. Front Chem. 2014; 2:11. PMID: 24790980.
      View in: PubMed
    9. McCarron ST, Feliciano M, Johnson JN, Chambers JJ. Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles. Bioorg Med Chem Lett. 2013 Apr 15; 23(8):2395-8. PMID: 23489632.
      View in: PubMed
    10. Chambers JJ. Delivery of therapeutics to the central nervous system. Adv Drug Deliv Rev. 2012 May 15; 64(7):589. PMID: 22388004.
      View in: PubMed
    11. Vytla D, Combs-Bachmann RE, Hussey AM, McCarron ST, McCarthy DS, Chambers JJ. Prodrug approaches to reduce hyperexcitation in the CNS. Adv Drug Deliv Rev. 2012 May 15; 64(7):666-85. PMID: 22138074.
      View in: PubMed
    12. Vytla D, Combs-Bachmann RE, Hussey AM, Hafez I, Chambers JJ. Silent, fluorescent labeling of native neuronal receptors. Org Biomol Chem. 2011 Oct 21; 9(20):7151-61. PMID: 21897969.
      View in: PubMed
    13. Jackman SL, Babai N, Chambers JJ, Thoreson WB, Kramer RH. A positive feedback synapse from retinal horizontal cells to cone photoreceptors. PLoS Biol. 2011 May; 9(5):e1001057. PMID: 21559323.
      View in: PubMed
    14. Wimmer E, Najafabadi R, Young GA, Ballard JD, Angeliu TM, Vollmer J, Chambers JJ, Niimi H, Shaw JB, Freeman C, Christensen M, Wolf W, Saxe P. Ab initio calculations for industrial materials engineering: successes and challenges. J Phys Condens Matter. 2010 Sep 29; 22(38):384215. PMID: 21386549.
      View in: PubMed
    15. Feliciano M, Vytla D, Medeiros KA, Chambers JJ. The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15; 18(22):7731-8. PMID: 20646926.
      View in: PubMed
    16. Chambers JJ, Kramer RH. Light-activated ion channels for remote control of neural activity. Methods Cell Biol. 2008; 90:217-32. PMID: 19195553.
      View in: PubMed
    17. Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K(+) channel and a molecular photoswitch. J Neurophysiol. 2006 Nov; 96(5):2792-6. PMID: 16870840.
      View in: PubMed
    18. McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13; 49(14):4269-74. PMID: 16821786.
      View in: PubMed
    19. Kramer RH, Chambers JJ, Trauner D. Photochemical tools for remote control of ion channels in excitable cells. Nat Chem Biol. 2005 Dec; 1(7):360-5. PMID: 16370371.
      View in: PubMed
    20. Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 3; 126(43):13886-7. PMID: 15506725.
      View in: PubMed
    21. Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem. 2003 Jul 31; 46(16):3526-35. PMID: 12877591.
      View in: PubMed
    22. Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. Bioorg Med Chem Lett. 2002 Aug 5; 12(15):1997-9. PMID: 12113827.
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    23. Chambers JJ, Nichols DE. A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor. J Comput Aided Mol Des. 2002 Jul; 16(7):511-20. PMID: 12510883.
      View in: PubMed
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