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James J Chambers PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address602 Lederle Graduate Research Tower
Amherst, MA 01003
Phone413-545-3864
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rigano A, Ehmsen S, Öztürk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C. Author Correction: Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications. Nat Methods. 2022 Feb; 19(2):256. PMID: 34952955.
      Citations:    Fields:    
    2. Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C. Author Correction: Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model. Nat Methods. 2022 Feb; 19(2):255. PMID: 34980906.
      Citations:    Fields:    
    3. Rigano A, Ehmsen S, Öztürk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C. Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications. Nat Methods. 2021 12; 18(12):1489-1495. PMID: 34862503.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C. Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model. Nat Methods. 2021 12; 18(12):1427-1440. PMID: 34862501.
      Citations: 4     Fields:    Translation:HumansAnimals
    5. Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann RR, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis SC, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins GG, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel JA, Plantard L, Podder S, Rexhepaj E, Royon A, Saari MA, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright GD, Nitschke R. QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy. J Microsc. 2021 10; 284(1):56-73. PMID: 34214188.
      Citations: 5     Fields:    
    6. Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR. Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. FEBS J. 2021 05; 288(9):2930-2955. PMID: 33175445.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Jiang Z, Liu H, He H, Yadava N, Chambers JJ, Thayumanavan S. Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations. Bioconjug Chem. 2020 05 20; 31(5):1344-1353. PMID: 32208679.
      Citations: 10     Fields:    Translation:HumansCells
    8. Castellani CM, Torres-Ocampo AP, Breffke J, White AB, Chambers JJ, Stratton MM, Maresca TJ. Live-cell FLIM-FRET using a commercially available system. Methods Cell Biol. 2020; 158:63-89. PMID: 32423651.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Afonso O, Castellani CM, Cheeseman LP, Ferreira JG, Orr B, Ferreira LT, Chambers JJ, Morais-de-Sá E, Maresca TJ, Maiato H. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife. 2019 08 19; 8. PMID: 31424385.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Melzer ES, Sein CE, Chambers JJ, Siegrist MS. DivIVA concentrates mycobacterial cell envelope assembly for initiation and stabilization of polar growth. Cytoskeleton (Hoboken). 2018 12; 75(12):498-507. PMID: 30160378.
      Citations: 16     Fields:    Translation:Cells
    11. McCarron ST, Chambers JJ. Modular chemical probes for visualizing and tracking endogenous ion channels. Neuropharmacology. 2015 Nov; 98:41-7. PMID: 25866020.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Combs-Bachmann RE, Johnson JN, Vytla D, Hussey AM, Kilfoil ML, Chambers JJ. Ligand-directed delivery of fluorophores to track native calcium-permeable AMPA receptors in neuronal cultures. J Neurochem. 2015 May; 133(3):320-9. PMID: 25640258.
      Citations:    Fields:    Translation:AnimalsCells
    13. Hussey AM, Chambers JJ. Methods to locate and track ion channels and receptors expressed in live neurons. ACS Chem Neurosci. 2015 Jan 21; 6(1):189-98. PMID: 25307447.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Lin WC, Davenport CM, Mourot A, Vytla D, Smith CM, Medeiros KA, Chambers JJ, Kramer RH. Engineering a light-regulated GABAA receptor for optical control of neural inhibition. ACS Chem Biol. 2014 Jul 18; 9(7):1414-9. PMID: 24819442.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    15. Gann AW, Amoroso JW, Einck VJ, Rice WP, Chambers JJ, Schnarr NA. A photoinduced, benzyne click reaction. Org Lett. 2014 Apr 04; 16(7):2003-5. PMID: 24625300.
      Citations: 5     Fields:    
    16. Chambers JJ. Delivery of chemical cargo to endogenous proteins on live cells. Front Chem. 2014; 2:11. PMID: 24790980.
      Citations:    
    17. McCarron ST, Feliciano M, Johnson JN, Chambers JJ. Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles. Bioorg Med Chem Lett. 2013 Apr 15; 23(8):2395-8. PMID: 23489632.
      Citations: 1     Fields:    Translation:Cells
    18. Chambers JJ. Delivery of therapeutics to the central nervous system. Adv Drug Deliv Rev. 2012 May 15; 64(7):589. PMID: 22388004.
      Citations:    Fields:    Translation:HumansAnimals
    19. Vytla D, Combs-Bachmann RE, Hussey AM, McCarron ST, McCarthy DS, Chambers JJ. Prodrug approaches to reduce hyperexcitation in the CNS. Adv Drug Deliv Rev. 2012 May 15; 64(7):666-85. PMID: 22138074.
      Citations: 1     Fields:    Translation:HumansAnimals
    20. Vytla D, Combs-Bachmann RE, Hussey AM, Hafez I, Chambers JJ. Silent, fluorescent labeling of native neuronal receptors. Org Biomol Chem. 2011 Oct 21; 9(20):7151-61. PMID: 21897969.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Jackman SL, Babai N, Chambers JJ, Thoreson WB, Kramer RH. A positive feedback synapse from retinal horizontal cells to cone photoreceptors. PLoS Biol. 2011 May; 9(5):e1001057. PMID: 21559323.
      Citations: 34     Fields:    Translation:AnimalsCells
    22. Wimmer E, Najafabadi R, Young GA, Ballard JD, Angeliu TM, Vollmer J, Chambers JJ, Niimi H, Shaw JB, Freeman C, Christensen M, Wolf W, Saxe P. Ab initio calculations for industrial materials engineering: successes and challenges. J Phys Condens Matter. 2010 Sep 29; 22(38):384215. PMID: 21386549.
      Citations:    Fields:    
    23. Feliciano M, Vytla D, Medeiros KA, Chambers JJ. The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15; 18(22):7731-8. PMID: 20646926.
      Citations: 1     Fields:    Translation:HumansCells
    24. Chambers JJ, Kramer RH. Light-activated ion channels for remote control of neural activity. Methods Cell Biol. 2008; 90:217-32. PMID: 19195553.
      Citations: 4     Fields:    Translation:AnimalsCells
    25. Chambers JJ, Banghart MR, Trauner D, Kramer RH. Light-induced depolarization of neurons using a modified Shaker K(+) channel and a molecular photoswitch. J Neurophysiol. 2006 Nov; 96(5):2792-6. PMID: 16870840.
      Citations: 33     Fields:    Translation:AnimalsCells
    26. McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13; 49(14):4269-74. PMID: 16821786.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Kramer RH, Chambers JJ, Trauner D. Photochemical tools for remote control of ion channels in excitable cells. Nat Chem Biol. 2005 Dec; 1(7):360-5. PMID: 16370371.
      Citations: 25     Fields:    Translation:AnimalsCells
    28. Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 03; 126(43):13886-7. PMID: 15506725.
      Citations: 12     Fields:    Translation:AnimalsCells
    29. Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. J Med Chem. 2003 Jul 31; 46(16):3526-35. PMID: 12877591.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. Bioorg Med Chem Lett. 2002 Aug 05; 12(15):1997-9. PMID: 12113827.
      Citations: 3     Fields:    Translation:AnimalsCells
    31. Chambers JJ, Nichols DE. A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor. J Comput Aided Mol Des. 2002 Jul; 16(7):511-20. PMID: 12510883.
      Citations: 12     Fields:    Translation:Humans
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